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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Median toxic dose required for a toxic effect in 50% of the population






2. Main route of metabolism for benzodiazepines






3. Agents having higher sedation and antimuscarinic effects than other TCA's






4. Drugs used in the management of angina






5. Methylxanthine derivative used as a remedy for intermittent claudication






6. What do beta cells in the pancreas produce?






7. Drug causes teeth discoloration






8. The ratio of the rate of elimination of a drug to its plasma concentration






9. Important in synthesis of glucose to glycogen in the liver






10. Hormone inhibiting prolactin release






11. Sedative - Hypnotics action






12. Leads to respiratory depression progressing to coma and death






13. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients






14. Phenylisopropylamines that are used legitimately and abused for narcolepsy - attention deficit disorder - and weight reduction






15. Antidote for tissue plasminogen activator (t - PA) - streptokinase






16. Antidote for arsenic - mercury - lead - and gold poisoning






17. Ergot alkaloid used as an illicit drug






18. Prototype antagonist of H1 and H2 receptors






19. Inhibitors of CYP450






20. Approved for use in severe pulmonary HTN






21. Drug used in Chagas disease






22. Class of anti - arrhythmics that has a pro - arrhythmic effect (CAST trial) - therefore are used as last line agents






23. Anti - arrhythmic with 15 second duration of action






24. Vitamin K dependent anticoagulant






25. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock






26. Laboratory value required to be monitored for patients on valproic acid


27. Type of resistance found with vancomycin






28. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction






29. Agents used in Huntington's Disease






30. Very rapid acting insulin - having fastest onset and shortest duration of action






31. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)






32. Diuretic used to treat primary aldosteronism






33. TCA used in chronic pain - enuresis - and ADD






34. '5HT-1d agonist used for migraine headaches '






35. SelectiveB1 Receptor blockers that may be useful in treating patients even though they have asthma






36. Used intranasally and decreases bone resorption






37. Microtubule inhibitor that causes peripheral neuropathy - foot drop (eg. ataxia) - and 'pins and needles' sensation






38. Non - selective Beta - blocker also used for migraine prophylaxis






39. MOA of nystatin






40. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures






41. Except for these agents all SSRI have significant inhibition of CytP450 enzymes






42. Longer acting local anesthetics which are less dependent on vasoconstrictors






43. DOC for paroxysmal supraventricular tachycardia (PSVT)






44. Tolerance to all effects of opioid agonists can develop except






45. DOC for status epilepticus






46. Antipsychotic having the weakest autonomic effects






47. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention






48. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction






49. GABA agonist in the spinal cord






50. 3 zones of adrenal cortex and their products