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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Median toxic dose required for a toxic effect in 50% of the population
Skeletal muscle tremor - tachycardia
Scopolamine - meclizine
Haloperidol
TD50
2. Main route of metabolism for benzodiazepines
Dry cough
IV administration
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Hepatic
3. Agents having higher sedation and antimuscarinic effects than other TCA's
Prostaglandin PGF2a
Tertiary amines
Protease inhibitors
Dry cough
4. Drugs used in the management of angina
Aspirin - Nitrates - CCB - and Beta blockers
Hepatic
GABA- related targets
IV and IM (only LMW)
5. Methylxanthine derivative used as a remedy for intermittent claudication
Maprotiline
Pentoxifylline
Morphine and fentanyl
Infants
6. What do beta cells in the pancreas produce?
Sulfasalazine
Glucagon
Insulin
N- acetylcysteine (Mucomyst)
7. Drug causes teeth discoloration
Indomethacin
Tetracycline
Cyanocobalamin (Vit B12)
Hypercalcemia
8. The ratio of the rate of elimination of a drug to its plasma concentration
Clearance (CL)
Steady state
Iron deiodinates thyroxine
Classic
9. Important in synthesis of glucose to glycogen in the liver
Atracurium
Thick ascending limb
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
GLUT 2
10. Hormone inhibiting prolactin release
Degradation of fibrin clots and are administered IV
Hallucinations resembling psychosis
Dopamine
Nevirapine - amprenavir
11. Sedative - Hypnotics action
Reduce inhibition - suppress anxiety - and produce relaxation
Disulfiram
Thyroxine
NSAIDS
12. Leads to respiratory depression progressing to coma and death
Steady state
Clonidine - and methyldopa
Codeine - hydrocodone - and oxycodone
Overdose of opioids
13. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients
Beta blockers
Ethanol
Glucagon
L- thyroxine (T4)
14. Phenylisopropylamines that are used legitimately and abused for narcolepsy - attention deficit disorder - and weight reduction
GLUT 4
Penicillamine
Amphetamines
Tamsulosin (Flomax)
15. Antidote for tissue plasminogen activator (t - PA) - streptokinase
Midazolam
Aminocaproic acid
Lithium
Allopurinol
16. Antidote for arsenic - mercury - lead - and gold poisoning
N- acetylcysteine (Mucomyst)
Physostigmine
Epinephrine
Dimercaprol
17. Ergot alkaloid used as an illicit drug
Amoxicillin
Gingival hyperplasia
Rhabdomyolysis and Hepatotoxicity
LSD
18. Prototype antagonist of H1 and H2 receptors
Fluorocarbons and Industrial solvents
Diphenhydramine and cimetridine - respectively
Neutro - leuko and thrombocytopenia
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
19. Inhibitors of CYP450
Dimercaprol
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
ORAL vancomycin
Abstinence syndrome
20. Approved for use in severe pulmonary HTN
Morphine
PGI2 (epoprostenol)
Morphine - methadone - meperidine - and fentanyl
Clopidogrel and ticlopidine
21. Drug used in Chagas disease
Neuromuscular blocking drugs
Maprotiline
Erythromycin
Nifurtimox
22. Class of anti - arrhythmics that has a pro - arrhythmic effect (CAST trial) - therefore are used as last line agents
Class IC (flecainide - propafenone - moricizine)
Octreotide
Epinephrine
Calcium channel blockers
23. Anti - arrhythmic with 15 second duration of action
Adenosine
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
Drug induced Parkinsonism
Delavirdine - efavirenz - and ribavirin
24. Vitamin K dependent anticoagulant
Amoxapine
Halothane
Half - life (T1/2)
Warfarin (PT)
25. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Pulmonary embolism and DVT
Class IC (flecainide - propafenone - moricizine)
Beta1 agonists
Glargine (Lantus) - detemir
26. Laboratory value required to be monitored for patients on valproic acid
27. Type of resistance found with vancomycin
Hyperkalemia
Point mutation
Use in IgE mediated allergic reaction
Minocycline
28. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction
Neuromuscular blocking drugs
Pilocarpine - carbachol - physostigmine
SEVERE myelosuppression
Bromocriptine
29. Agents used in Huntington's Disease
Buspirone
Desmopressin (DDAVP)
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
30. Very rapid acting insulin - having fastest onset and shortest duration of action
Lithium toxicity
Lispro (Humalog) - aspart - glulisine
Citalopram and its metabolite escitalopram
Magnesium sulfate
31. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)
Sodium channel blockers
Little C- peptide
Entacapone and Tolcapone
Prazosin - terazosin - doxazosin
32. Diuretic used to treat primary aldosteronism
N- acetylcysteine (Mucomyst)
Spironolactone
Propofol
Primaquine
33. TCA used in chronic pain - enuresis - and ADD
Imipramine
Abciximab - tirofiban and eptifibatide
Deferoxamine
Full agonist
34. '5HT-1d agonist used for migraine headaches '
Beta - blockers
Sumatriptan - naratriptan - and rizatriptan
Postsynaptic Mu receptors
Metronidazole
35. SelectiveB1 Receptor blockers that may be useful in treating patients even though they have asthma
pregnancy and with K+
AZT (zidovudine)
Ribavirin
Acebutolol - atenolol - esmolol - metoprolol
36. Used intranasally and decreases bone resorption
Alprazolam
Calcitonin (salmon prep)
Neutro - leuko and thrombocytopenia
Postsynaptic Mu receptors
37. Microtubule inhibitor that causes peripheral neuropathy - foot drop (eg. ataxia) - and 'pins and needles' sensation
Vitamin D
Agranulocytosis
Insulin
Vincristine
38. Non - selective Beta - blocker also used for migraine prophylaxis
Thioridazine
Propranolol
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Mannitol
39. MOA of nystatin
Hypertension
Phenoxybenzamine
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Bind ergosterol in fungal cell membrane
40. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Bupropion
Desflurane
Beta - blockers such as propranolol
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
41. Except for these agents all SSRI have significant inhibition of CytP450 enzymes
Lupus - like syndrome
Indomethacin
Citalopram and its metabolite escitalopram
Cocaine 'super - speed'
42. Longer acting local anesthetics which are less dependent on vasoconstrictors
Salmeterol
Tetracaine and bupivacaine
Side - effect profile and prior pt response
Aspirin
43. DOC for paroxysmal supraventricular tachycardia (PSVT)
Adenosine
L- asparaginase
Heparin
Atropine - pralidoxime (2- PAM)
44. Tolerance to all effects of opioid agonists can develop except
Neuroleptanesthesia
Aspirin - Nitrates - CCB - and Beta blockers
Miosis and constipation
Ferrous sulfate
45. DOC for status epilepticus
Hypertrichosis
Geriatrics due to its CNS (depression) effects
Diazepam
Temazpam - trizolam - flurazepam
46. Antipsychotic having the weakest autonomic effects
Haloperidol
Geriatrics due to its CNS (depression) effects
Venlafaxine
Acetazolamide
47. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Naltrexone
Depression of medullary and cardiovascular centers
Bethanechol
48. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction
Leuprolide
Reducing progression of heart failure (never use in acute heart failure)
Alkylating agent
Meperidine
49. GABA agonist in the spinal cord
Serum ammonia and LFT's
Cocaine
Baclofen
ACE inhibitors
50. 3 zones of adrenal cortex and their products
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Cyclophosphamide
N- acetylcysteine