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Bio Engineering
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Subject
:
engineering
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. ____ is the process by which cells involved in inflammation internalize and destroy foreign material.
Phagocytosis
chemotaxis
Protein Absorption
Hemocompatibility
2. Neutrophils remove bacteria/damaged cell debris from a wound site through the process of ___.
Negative Feedback
Stress
phagocytosis
Number of polymers - molecular weight of polymer
3. List two chemical characteristics of polymers:
Hemophilia
Intermolecular bonding - molecular weight
Enzyme cascade
Endothelial cells
4. Cells that proliferate slowly over time (aka liver)
Stable cells
Amide
Polymers - cross linking of polymers
Negative Feedback
5. Cells that proliferate rapidly (fibroblasts)
Thrombin
labile cells
Collagenase/Remodelling
negative feedback
6. Two things needed in the end product of the creation of a scab
Large
Stress
Number of polymers - molecular weight of polymer
Polymers - cross linking of polymers
7. The two types of white blood cells:
Metals
neutrophils - macrophages
alloys - passivation
glassy to rubbery
8. Classify the following polymers into appropriate families based on their bond structure i.e. the polymer is an example of poly ____.
Calibration
Amide
Regeneration/Repair
Chemotaxis
9. Activates tissue factors aka endothelial damage
neutrophils - macrophages
Collagenase
Damage to cell membranes
Metals
10. Keloid scars form due to disfunction of ____.
Thrombin
labile cells
Collagenase/Remodelling
Hemophilia
11. Collagen ____ is responsible for the gradual gain in mechanical properties of wounded tissue between roughly 4 and 52 weeks post- injury.
Hemocompatibility
cross - linking
Phagocytosis
Stress
12. Where are the tissue factors found when they're inactivated
negative feedback
in cytoplasm
free radical
labile cells
13. Which of polyermization (condensation/free radical) would you choose to obtain a polymer of high molecular weight?
in cytoplasm
Compression molding
hypoxin - angiogenesis
Free Radical
14. The fatigue limit is value of applied stress below which a material will not fail no matter the number of ____ applied.
Allogeneic
in cytoplasm
cycles
Plasticizers
15. The fatigue limit is the ___ below which the material can withstand an infinite number of cycles without failure.
Plasticizers
stress
phagocytosis
scars
16. ______ Molecular weight degrades slower than lower MW
Negative Feedback
Higher
chemotaxis
Chemotaxis
17. ____- are polymers that can be repeatedly softened by heating and hardened by cooling.
Thermoplastics
Negative Feedback
Hemophilia
Collagenase/Remodelling
18. Thrombin also activates protein C-- which deactivates earlier factors in the cascade is known as ___ ___.
Negative Feedback
Large
Intermolecular bonding - molecular weight
hypoxin - angiogenesis
19. Drawback of micromaching
in cytoplasm
Permanent cells
Have to be in a clean room free of dust and biocontamination - expensive
heparin
20. Disfunction of _____ (cells) producing collagenase during the _____ phase of wound healing may form Keloid scars.
macrophages - proliferation
Plasticizers
fibrinogen - factor XIII
Negative Feedback
21. The trigger for activation of enzymes (anything but endothelial cells!)
Amide
Positive Feedback
binding
Thrombin
22. Process that makes long fibers (fiber drawing) by forcing a fluid through an oriface.
Intermolecular bonding - molecular weight
Extrusion
Free Radical
Water - oxygen - metal
23. Cell found in the lining of the blood vessels that release heparin and are a part of the negative feedback system.
mast cells
cycles
Large
Metals
24. Enzymes (proteins) are not activated only when they are in contact with this type of cells
Mast - Collagen
Endothelial cells
autologous
Protein Absorption
25. The fibrous capsule surrounding a permanent implant is primarily composed of ___ cells and ____ (matrix).
Large
photoactive polymers
Stress
Mast - Collagen
26. A molecular pathway in which the product of each reaction catalyzes the subsequent reaction.
Hemophilia
Enzyme cascade
alloys - passivation
in cytoplasm
27. This cleaves into fibrinogen which creates fibrin (a sticky enzyme that allows blood to clot)
Lower
Heparin
binding
Thrombin
28. Polyethylene oxide grafting to biomaterials was developed to prevent coagulation by interfering with/preventing ___ ___.
Mast - Collagen
Calibration
Protein Absorption
Extrusion
29. Process of producing new blood vessels due to a lack on oxygen and thus inducing VEGF.
angiogenesis
Calibration
Plastic
binding
30. Higher Molecular weight degrades slower than ____ MW
Hemocompatibility
negative feedback
Endothelial cells
Lower
31. What type of materials are used for photolithography? (substrate is a silicon wafer - built up material is some _____ ____ )
photoactive polymers
Damage to cell membranes
Large
Intermolecular bonding - molecular weight
32. Damaged cells at the site of injury (mast cells) release ___ (glycosaminoglycan).
Bioactive
fibrinogen - factor XIII
binding
heparin
33. Keloid scars forms because disfuntion of
Heparin
Compression molding
Collagenase
photoactive polymers
34. Cells that don't proliferate (neurons)
alloys - passivation
Regeneration/Repair
Permanent cells
Endothelial cells
35. Thrombin activates several upstream factors.
mast cells
Endothelial cells
Positive Feedback
fibrinogen - factor XIII
36. Vascular endothelial growth factor is produced in response to ___ and stimulates ___.
Stress
Plastic
alloys - passivation
hypoxin - angiogenesis
37. Foreign body giants cells are produced by fusion of ___.
Thrombin
Free Radical
heparin
Macrophages
38. In order to produce a blood clot - thrombin cleaves/activates ____ and ____.
fibrinogen - factor XIII
Collagenase/Remodelling
Lower
Negative Feedback
39. The fatigue limit is the ___ below which the material can withstand an infinite number of cycles without failure
Mast - Collagen
Stress
micromachining
Extrusion
40. This type of feedback creates
low
neutrophils - macrophages
negative feedback
micromachining
41. ____ are enzymes responsible for protein degradation.
Free Radical
Proteases
macrophages - proliferation
stress
42. A condensation polymerization results with an ester bond between two reactants and this comes off as a result
Free Radical
Extrusion
Water
Calibration
43. Type of fiber drawing that controls details of a polymer by etching on a microscopic level; thus - controlling mechanical properties as well
stress
angiogenesis
micromachining
Have to be in a clean room free of dust and biocontamination - expensive
44. The formation of rust due to corrosion in the body is due to the reaction between these 3 things ____ - ____ - and ____ .
Proteases
Water - oxygen - metal
in cytoplasm
Permanent cells
45. Resulting from the build up of too much collagen at the surface of injury during the granulation tissue stage of proliferation
photoactive polymers
Polydesperity index
scars
Large
46. Condition in which patients can literally bleed to death.
Large
in cytoplasm
Hemophilia
Proteases
47. Are polymer additives used to lower glass transition temperature temperature.
Plasticizers
Proteases
macrophages - proliferation
Macrophages
48. The process of calibration establishes a quantitative relationship between ____ __ ___ _____ and the direct output of the intstrument (for example time/volume in GPC).
binding
low
Water
standards of known properties
49. _____ establishes a quantitative relationship between measured output values from an instrument and known standards of what is being measured.
Plastic
Calibration
Plasticizers
free radical
50. Mast cells release this
Collagenase
heparin
Bioactive
Stable cells
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