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Test your basic knowledge |
Bio Engineering
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Study First
Subject
:
engineering
Instructions:
Answer 50 questions in 15 minutes.
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.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. GPC separates molecules on the basis of size by their passage over a column packed with a porous matrix. ___ molecules pass through the column more quickly.
Amide
Number of polymers - molecular weight of polymer
Free Radical
Large
2. Is directed cell migration in response to a concentration gradient of soluble molecules.
Chemotaxis
Have to be in a clean room free of dust and biocontamination - expensive
Bioactive
in cytoplasm
3. Thrombin activates several upstream factors.
Positive Feedback
Collagenase
Lower
glassy to rubbery
4. ____ is a measurement that characterizes the breadth of the distribution of a polymer's molecular weight.
Polydesperity index
autologous
Calibration
in cytoplasm
5. ____ binds to anti- thrombin III (thrombin inhibitor) and increases its potency 1000- fold.
scars
free radical
Large
Heparin
6. Resulting from the build up of too much collagen at the surface of injury during the granulation tissue stage of proliferation
Polymers - cross linking of polymers
Endothelial cells
scars
alloys - passivation
7. Cells that don't proliferate (neurons)
Permanent cells
cross - linking
Endothelial cells
Extrusion
8. Which of polyermization (condensation/free radical) would you choose to obtain a polymer of high molecular weight?
Free Radical
Intermolecular bonding - molecular weight
Negative Feedback
Extrusion
9. What types of wound healing results from injury with inflammation?
Regeneration/Repair
Permanent cells
Proteases
Polymers - cross linking of polymers
10. Polyethylene oxide grafting to biomaterials was developed to prevent coagulation by interfering with/preventing ___ ___.
Protein Absorption
angiogenesis
free radical
alloys - passivation
11. Keloid scars form due to disfunction of ____.
phagocytosis
Collagenase/Remodelling
Phagocytosis
Positive Feedback
12. Classify the following polymers into appropriate families based on their bond structure i.e. the polymer is an example of poly ____.
Amide
Allogeneic
negative feedback
Extrusion
13. No healing of damage neurons is the result of ____ cells that are not able to ____.
neutrophils - macrophages
Permanent - replicate
Proteases
Endothelial cells
14. Cells that proliferate slowly over time (aka liver)
Stable cells
scars
Thermoplastics
Regeneration/Repair
15. What type of materials are used for photolithography? (substrate is a silicon wafer - built up material is some _____ ____ )
Amide
Collagenase
photoactive polymers
Metals
16. ____ are enzymes responsible for protein degradation.
Permanent cells
micromachining
Proteases
Bioactive
17. The glass transition temperature of a poymer at which a polymer transforms from a ____ state to a ___ state.
glassy to rubbery
Permanent cells
low
angiogenesis
18. Process of producing new blood vessels due to a lack on oxygen and thus inducing VEGF.
angiogenesis
Polymers - cross linking of polymers
mast cells
Free Radical
19. Process that makes long fibers (fiber drawing) by forcing a fluid through an oriface.
scars
Plastic
Negative Feedback
Extrusion
20. During granulation stage of proliferation - growth factors that produce this ____(answer)_____ that function in degrading fibrin and replacing it with collagen.
Calibration
Proteases
Thrombin
glassy to rubbery
21. The trigger for activation of enzymes (anything but endothelial cells!)
standards of known properties
binding
in cytoplasm
Free Radical
22. You're working on a square polymeric implant of 5cm length and 2mm thick. You've been asked to suggest a precise way to fabricate it - what would you suggest?
Hemocompatibility
Compression molding
glassy to rubbery
scars
23. Addition polymerization is commonly initiated by ___ - atoms that have an unpaired electron.
free radical
Collagenase
Hemophilia
Phagocytosis
24. ____ grafts are derived from the other humans.
Water
free radical
Allogeneic
Protein Absorption
25. _____ establishes a quantitative relationship between measured output values from an instrument and known standards of what is being measured.
Proteases
Polydesperity index
Calibration
Collagenase
26. List two chemical characteristics of polymers:
Intermolecular bonding - molecular weight
Negative Feedback
Water
stress
27. The fibrous capsule surrounding a permanent implant is primarily composed of ___ cells and ____ (matrix).
Negative Feedback
binding
Thrombin
Mast - Collagen
28. Collagen ____ is responsible for the gradual gain in mechanical properties of wounded tissue between roughly 4 and 52 weeks post- injury.
cross - linking
Extrusion
Water
Stress
29. Cardiac bypass surgery in which a vein from a patient's leg is transplanted to the patient's heart is an example of the us of ____ tissue.
cycles
autologous
Chemotaxis
Bioactive
30. ______ Molecular weight degrades slower than lower MW
binding
Proteases
Higher
Compression molding
31. The fatigue limit is the ___ below which the material can withstand an infinite number of cycles without failure.
autologous
stress
Thrombin
neutrophils - macrophages
32. In order to produce a blood clot - thrombin cleaves/activates ____ and ____.
Positive Feedback
fibrinogen - factor XIII
Chemotaxis
Thermoplastics
33. Keloid scars forms because disfuntion of
macrophages - proliferation
Collagenase
negative feedback
Enzyme cascade
34. A molecular pathway in which the product of each reaction catalyzes the subsequent reaction.
Positive Feedback
heparin
Enzyme cascade
Stable cells
35. Mast cells release this
heparin
Polydesperity index
macrophages - proliferation
chemotaxis
36. High conductivity - isotropic - crystalline
Extrusion
Hemophilia
Metals
Bioactive
37. Type of fiber drawing that controls details of a polymer by etching on a microscopic level; thus - controlling mechanical properties as well
Stress
micromachining
Compression molding
Thrombin
38. ____ describes the ability of a device to function appropriately in the presence of blood.
Protein Absorption
Hemocompatibility
Large
low
39. This cleaves into fibrinogen which creates fibrin (a sticky enzyme that allows blood to clot)
Proteases
scars
Water - oxygen - metal
Thrombin
40. The calculation of a polymer's molecular weight (weight average and number number average) is based upon values for ____ and ___.
Number of polymers - molecular weight of polymer
autologous
stress
Permanent cells
41. Cells that proliferate rapidly (fibroblasts)
Stable cells
Polymers - cross linking of polymers
fibrinogen - factor XIII
labile cells
42. Essentially all metallic biomaterials are ____ - comprised of two or more metals. One of these metals is selected for its ability to support _____ - the formation of a stable oxide layer that resists further corrosion.
alloys - passivation
Polymers - cross linking of polymers
mast cells
Water
43. Activates tissue factors aka endothelial damage
Polydesperity index
Have to be in a clean room free of dust and biocontamination - expensive
Damage to cell membranes
Proteases
44. The process of calibration establishes a quantitative relationship between ____ __ ___ _____ and the direct output of the intstrument (for example time/volume in GPC).
heparin
standards of known properties
angiogenesis
Protein Absorption
45. A condensation polymerization results with an ester bond between two reactants and this comes off as a result
Metals
Water
in cytoplasm
Polydesperity index
46. The fatigue limit is the ___ below which the material can withstand an infinite number of cycles without failure
Protein Absorption
cycles
heparin
Stress
47. Condition in which patients can literally bleed to death.
standards of known properties
Large
free radical
Hemophilia
48. Drawback of micromaching
Have to be in a clean room free of dust and biocontamination - expensive
Permanent - replicate
Phagocytosis
Collagenase
49. Where are the tissue factors found when they're inactivated
Polydesperity index
in cytoplasm
Metals
Hemophilia
50. Enzyme that really gets the polmerization going!
Collagenase/Remodelling
Thrombin
labile cells
negative feedback
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