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Bio Engineering
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Study First
Subject
:
engineering
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Relative to free radical polymerization - condensation polymerization generally produces polymer of relatively ____ molecular weight.
negative feedback
micromachining
low
cycles
2. ______ Molecular weight degrades slower than lower MW
alloys - passivation
Free Radical
Higher
photoactive polymers
3. ____ grafts are derived from the other humans.
Thrombin
Higher
Polymers - cross linking of polymers
Allogeneic
4. Collagen ____ is responsible for the gradual gain in mechanical properties of wounded tissue between roughly 4 and 52 weeks post- injury.
Higher
binding
in cytoplasm
cross - linking
5. Vascular endothelial growth factor is produced in response to ___ and stimulates ___.
hypoxin - angiogenesis
Calibration
neutrophils - macrophages
Protein Absorption
6. Higher Molecular weight degrades slower than ____ MW
labile cells
in cytoplasm
Lower
Chemotaxis
7. Keloid scars form due to disfunction of ____.
Metals
Chemotaxis
Polymers - cross linking of polymers
Collagenase/Remodelling
8. Are polymer additives used to lower glass transition temperature temperature.
alloys - passivation
heparin
negative feedback
Plasticizers
9. Which of polyermization (condensation/free radical) would you choose to obtain a polymer of high molecular weight?
alloys - passivation
Endothelial cells
Free Radical
Plastic
10. Rather than randomly moving - moves in a directed cell migration manner for specific functions.
Endothelial cells
Compression molding
chemotaxis
free radical
11. Mast cells release this
Allogeneic
heparin
Positive Feedback
Calibration
12. Foreign body giants cells are produced by fusion of ___.
Proteases
binding
Large
Macrophages
13. List two chemical characteristics of polymers:
binding
Regeneration/Repair
labile cells
Intermolecular bonding - molecular weight
14. The fibrous capsule surrounding a permanent implant is primarily composed of ___ cells and ____ (matrix).
Intermolecular bonding - molecular weight
macrophages - proliferation
Mast - Collagen
Allogeneic
15. The process of calibration establishes a quantitative relationship between ____ __ ___ _____ and the direct output of the intstrument (for example time/volume in GPC).
standards of known properties
alloys - passivation
binding
scars
16. Keloid scars forms because disfuntion of
Stress
Compression molding
hypoxin - angiogenesis
Collagenase
17. Condition in which patients can literally bleed to death.
Thrombin
Calibration
Hemophilia
Stress
18. Enzyme that really gets the polmerization going!
heparin
Calibration
Thrombin
Hemocompatibility
19. Enzymes (proteins) are not activated only when they are in contact with this type of cells
photoactive polymers
heparin
Endothelial cells
Heparin
20. ____ are enzymes responsible for protein degradation.
Large
binding
Proteases
Number of polymers - molecular weight of polymer
21. Drawback of micromaching
Positive Feedback
Have to be in a clean room free of dust and biocontamination - expensive
Thrombin
Metals
22. This type of feedback creates
Plasticizers
mast cells
negative feedback
phagocytosis
23. GPC separates molecules on the basis of size by their passage over a column packed with a porous matrix. ___ molecules pass through the column more quickly.
angiogenesis
Bioactive
negative feedback
Large
24. High conductivity - isotropic - crystalline
angiogenesis
photoactive polymers
Metals
Proteases
25. Cells that don't proliferate (neurons)
Permanent cells
Regeneration/Repair
Mast - Collagen
Damage to cell membranes
26. The trigger for activation of enzymes (anything but endothelial cells!)
scars
Water - oxygen - metal
binding
Bioactive
27. The fatigue limit is value of applied stress below which a material will not fail no matter the number of ____ applied.
glassy to rubbery
Water - oxygen - metal
Hemophilia
cycles
28. What type of materials are used for photolithography? (substrate is a silicon wafer - built up material is some _____ ____ )
photoactive polymers
Enzyme cascade
free radical
Collagenase/Remodelling
29. Type of fiber drawing that controls details of a polymer by etching on a microscopic level; thus - controlling mechanical properties as well
micromachining
heparin
mast cells
glassy to rubbery
30. Two things needed in the end product of the creation of a scab
standards of known properties
macrophages - proliferation
Polymers - cross linking of polymers
Compression molding
31. Classify the following polymers into appropriate families based on their bond structure i.e. the polymer is an example of poly ____.
Thrombin
Calibration
Negative Feedback
Amide
32. Polyethylene oxide grafting to biomaterials was developed to prevent coagulation by interfering with/preventing ___ ___.
Damage to cell membranes
alloys - passivation
Protein Absorption
Stable cells
33. During granulation stage of proliferation - growth factors that produce this ____(answer)_____ that function in degrading fibrin and replacing it with collagen.
Thrombin
Polydesperity index
Polymers - cross linking of polymers
Proteases
34. The formation of rust due to corrosion in the body is due to the reaction between these 3 things ____ - ____ - and ____ .
Water - oxygen - metal
chemotaxis
Have to be in a clean room free of dust and biocontamination - expensive
stress
35. In order to produce a blood clot - thrombin cleaves/activates ____ and ____.
fibrinogen - factor XIII
free radical
phagocytosis
binding
36. ____ describes the ability of a device to function appropriately in the presence of blood.
Hemocompatibility
Number of polymers - molecular weight of polymer
Endothelial cells
Water
37. Process that makes long fibers (fiber drawing) by forcing a fluid through an oriface.
Hemophilia
Plastic
Hemocompatibility
Extrusion
38. Neutrophils remove bacteria/damaged cell debris from a wound site through the process of ___.
Protein Absorption
Negative Feedback
phagocytosis
heparin
39. Resulting from the build up of too much collagen at the surface of injury during the granulation tissue stage of proliferation
Protein Absorption
Mast - Collagen
scars
binding
40. ____- are polymers that can be repeatedly softened by heating and hardened by cooling.
low
Thermoplastics
Hemocompatibility
Stress
41. Cells that proliferate rapidly (fibroblasts)
binding
alloys - passivation
labile cells
Hemophilia
42. Thrombin activates several upstream factors.
photoactive polymers
Thrombin
Positive Feedback
heparin
43. Essentially all metallic biomaterials are ____ - comprised of two or more metals. One of these metals is selected for its ability to support _____ - the formation of a stable oxide layer that resists further corrosion.
Negative Feedback
Thrombin
alloys - passivation
autologous
44. The fatigue limit is the ___ below which the material can withstand an infinite number of cycles without failure
Phagocytosis
neutrophils - macrophages
Stress
Compression molding
45. A condensation polymerization results with an ester bond between two reactants and this comes off as a result
angiogenesis
Free Radical
Water
Intermolecular bonding - molecular weight
46. Is directed cell migration in response to a concentration gradient of soluble molecules.
heparin
Chemotaxis
Thrombin
phagocytosis
47. The glass transition temperature of a poymer at which a polymer transforms from a ____ state to a ___ state.
chemotaxis
glassy to rubbery
Polymers - cross linking of polymers
Intermolecular bonding - molecular weight
48. What types of wound healing results from injury with inflammation?
Intermolecular bonding - molecular weight
Hemophilia
Phagocytosis
Regeneration/Repair
49. ____ is a measurement that characterizes the breadth of the distribution of a polymer's molecular weight.
Polydesperity index
in cytoplasm
labile cells
Regeneration/Repair
50. The calculation of a polymer's molecular weight (weight average and number number average) is based upon values for ____ and ___.
Metals
Number of polymers - molecular weight of polymer
Proteases
Intermolecular bonding - molecular weight
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