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GRE Chromosomal And Molecular Basis Of Inheritance
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Subjects
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gre
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science
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biology
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The most common phenotype in a natural population.
Wild Type
Mismatch Repair
Leading Strand
Monosomy X (XO)
2. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi
Crossing Over
Parental Types
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Law of Independent Assortment
3. Adenine doubles bonds thymine and guanine triple bonds cytosine.
Mutant Phenotypes
Recombinant Types (or Recombinants)
Cytogenetic Maps
Nitrogenous Bases of DNA
4. A change in genotype and phenotype due to the assimilation of external DNA by a cell.
The Haplo-diploid System
Trisomic
Transformation
DNA Polymerase
5. Each nucleotide (monomer) consists of a hydrophobic nitrogenous base (T - A - C - or G) - the sugar dioxyribose - and a phosphate group. The phosphate of one nucleotide is attached to the sugar of the next - making up the 'backbone' of alternating ph
Cri du Chat
Turner Syndrome
Genomic Imprinting
DNA Structure
6. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa
Aneuploidy
Recombinant Types (or Recombinants)
Hemophilia
Primer
7. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.
Lagging Strand
Farther apart
Deletion
Genomic Imprinting
8. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.
Nuclease
Bacteriophages
Origins of Replication
Farther apart
9. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.
Linkage Map
Nondisjunction
Transformation
DNA Ligase
10. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi
SRY
Nitrogenous Bases of DNA
Monosomic
Linkage Map
11. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.
Linked Genes
Duchenne Muscular Dystrophy
Recombinant Types (or Recombinants)
Translocation
12. An enzyme that can start an RNA chain from scratch. Joins RNA nucleotides together one at a time - making a primer complimentary to the template strand at the location where initiation of the new DNA strand will occur.
'The DNA Replication Machine'
Barr body
Process of DNA Polymerase Adding a Nucleotide
Primase
13. The two alleles for each gene separate during gamete formation.
Process of DNA Polymerase Adding a Nucleotide
Law of Segregation
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Recombinant Types (or Recombinants)
14. Genes located on the same chromosome that tend to be inherited together in genetic crosses. These results deviate from those expected from Mendel'S law of independent assortment.
Linked Genes
Dispersive Model of DNA Replication
Parental Types
Semiconservative Model of DNA Replication
15. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.
Polyploidy
Replication Fork
Females with XXX
Parental Types
16. The system for determining sex in most species of bees and ants. There are no sex chromosomes in these species - Females develop from fertilized ova and are thus diploid. Males - however - develop from unfertilized ova and are haploid; they have no f
The Z-W System
The Haplo-diploid System
Nuclease
Aneuploidy
17. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.
Map Units
DNA Polymerase
Polyploidy
DNA Structure
18. A chromosome is missing in a aneuploid cell.
Monosomic
DNA Ligase
Conservative Model of DNA Replication
Aneuploidy
19. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister
Chromosome Theory of Inheritance
Map Units
Duplication
Law of Independent Assortment
20. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th
Inversion
Duchenne Muscular Dystrophy
Map Units
Extranuclear Genes
21. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe
Farther apart
Chronic Myelogenous Leukemia (CML)
Aneuploidy
Topoisomerase
22. 1. deletion 2. duplication 3. inversion 4. translocation
SRY
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Monosomic
Nuclease
23. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.
SRY
Primase
Mismatch Repair
Cri du Chat
24. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.
The X-Y System
Polyploidy
'The DNA Replication Machine'
Law of Segregation
25. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.
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26. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.
'The DNA Replication Machine'
Lagging Strand
Okazaki Fragments
The Z-W System
27. An ordered list of the genetic loci along a particular chromosome.
Origins of Replication
Genetic Map
Down Syndrome
Telomerase
28. A result of nondisjuction of sex chromosomes. Do not exhibit any well-defined syndrome but tend to be somewhat taller than average.
Genomic Imprinting
Males with XYY
Topoisomerase
Deletion
29. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.
Down Syndrome
Chronic Myelogenous Leukemia (CML)
Mutant Phenotypes
The Z-W System
30. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.
Duchenne Muscular Dystrophy
Leading Strand
Monosomic
Map Units
31. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.
Mutant Phenotypes
Chronic Myelogenous Leukemia (CML)
Females with XXX
Nondisjunction
32. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes
Translocation
Barr body
DNA Ligase
Duplication
33. An enzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells - thus restoring their original length and compensating for the shortening that occurs during DNA replication. Made possible by the presence in the telomerase of a short
Reciprocal Translocation
Telomerase
DNA Structure
Origins of Replication
34. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.
Monosomy X (XO)
Law of Segregation
Nondisjunction
Farther apart
35. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.
Nondisjunction
Aneuploidy
Deletion
Klinefelter Syndrome
36. An enzyme that joins the sugar-phosphate backbones of the Okazaki fragments - forming a single new DNA strand.
Process of DNA Polymerase Adding a Nucleotide
DNA Ligase
The Haplo-diploid System
DNA Structure
37. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.
Okazaki Fragments
Aneuploidy
Translocation
Transformation
38. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.
Mutant Phenotypes
Cri du Chat
Duchenne Muscular Dystrophy
Polyploidy
39. Or phages. Viruses that infect bacteria.
Bacteriophages
The Haplo-diploid System
Primer
Origins of Replication
40. A result of nondisjuction of sex chromosomes. In this case - it is the result of an extra X chromosome in a male - producting XXY. People have male sex organs - but the testes are abnormally small and the man is sterile. Some breast enlargement and o
Mutant Phenotypes
Klinefelter Syndrome
Farther apart
Origins of Replication
41. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved
Okazaki Fragments
Helicase
Farther apart
Law of Segregation
42. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.
Monosomy X (XO)
Extranuclear Genes
The Haplo-diploid System
DNA Excision Repair
43. Each nucleotide added to a growing DNA strand is a nucleoside triphosphate - which is a sugar and a base with three phosphate groups. The triphosphate monomers used are chemically reactive - partly because their triphosphate tails have an unstable cl
Transformation
Process of DNA Polymerase Adding a Nucleotide
Sex-Linked Gene
Semiconservative Model of DNA Replication
44. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and
Semiconservative Model of DNA Replication
Nuclease
Conservative Model of DNA Replication
Cri du Chat
45. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.
Chronic Myelogenous Leukemia (CML)
Aneuploidy
Cytogenetic Maps
Genomic Imprinting
46. The most common type of translocation. A type of change in chromosome structure as a result of some sort of chromosomal breakage. In this - nonhomologous chromosome exchange fragments.
Semiconservative Model of DNA Replication
Dispersive Model of DNA Replication
Recombinant Types (or Recombinants)
Reciprocal Translocation
47. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory
Cri du Chat
Monosomic
Down Syndrome
Nuclease
48. Offspring that inherit a phenotype that matches one of the parental phenotypes.
Parental Types
Trisomic
DNA Ligase
Bacteriophages
49. The ___________ two genes are - the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency. This process can occasionally break the physical connection between genes on the same chromosome
Monosomy X (XO)
Chromosome Theory of Inheritance
Farther apart
Dispersive Model of DNA Replication
50. A genetic map based on recombination frequencies.
Linkage Map
Farther apart
Replication Fork
Wild Type
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