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Test your basic knowledge |
GRE Chromosomal And Molecular Basis Of Inheritance
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gre
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science
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biology
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.
Inversion
Transformation
Duchenne Muscular Dystrophy
Law of Independent Assortment
2. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.
Dispersive Model of DNA Replication
Lagging Strand
Chromosome Theory of Inheritance
Monosomy X (XO)
3. An enzyme that can start an RNA chain from scratch. Joins RNA nucleotides together one at a time - making a primer complimentary to the template strand at the location where initiation of the new DNA strand will occur.
Barr body
'The DNA Replication Machine'
Translocation
Primase
4. Alleles of genes on nonhomologous chromosome assort independently during gamete formation.
Genetic Map
Lagging Strand
Farther apart
Law of Independent Assortment
5. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th
Males with XYY
Extranuclear Genes
Nuclease
Cri du Chat
6. A chromosome is missing in a aneuploid cell.
Monosomic
Farther apart
DNA Ligase
Turner Syndrome
7. A result of nondisjuction of sex chromosomes. In this case - it is the result of an extra X chromosome in a male - producting XXY. People have male sex organs - but the testes are abnormally small and the man is sterile. Some breast enlargement and o
Females with XXX
Klinefelter Syndrome
Primer
Translocation
8. A change in genotype and phenotype due to the assimilation of external DNA by a cell.
DNA Structure
Process of DNA Polymerase Adding a Nucleotide
Transformation
Aneuploidy
9. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.
Klinefelter Syndrome
Genomic Imprinting
Dispersive Model of DNA Replication
DNA Excision Repair
10. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.
SRY
Wild Type
Cri du Chat
Translocation
11. According to this theory - Mendelian genes have specific loci (positions) on chromosomes - and it is the chromosomes that undergo segregation and independent assortment.
Down Syndrome
Primase
Chromosome Theory of Inheritance
Translocation
12. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.
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13. A genetic map based on recombination frequencies.
Turner Syndrome
Linkage Map
Nitrogenous Bases of DNA
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
14. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.
Genetic Map
Origins of Replication
Telomeres
Reciprocal Translocation
15. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved
Topoisomerase
Lagging Strand
Helicase
Nuclease
16. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory
Genomic Imprinting
Trisomic
Cytogenetic Maps
Down Syndrome
17. Or phages. Viruses that infect bacteria.
The X-Y System
Bacteriophages
Deletion
The Z-W System
18. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.
Crossing Over
Genetic Map
Deletion
Nondisjunction
19. 1. deletion 2. duplication 3. inversion 4. translocation
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Semiconservative Model of DNA Replication
Topoisomerase
Mutant Phenotypes
20. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.
Mutant Phenotypes
Linkage Map
Monosomy X (XO)
DNA Ligase
21. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.
Polyploidy
'The DNA Replication Machine'
Nitrogenous Bases of DNA
Bacteriophages
22. Can be distinguished from Watson and Crick'S semiconservative model in which the parent molecule somehow re-forms after the process of replication. Proved incorrect and support came out for the semiconservative model.
Transformation
Cri du Chat
DNA Excision Repair
Conservative Model of DNA Replication
23. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.
Recombinant Types (or Recombinants)
Cytogenetic Maps
Inversion
Barr body
24. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.
DNA Ligase
The X-Y System
The Z-W System
Duchenne Muscular Dystrophy
25. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.
Primase
Okazaki Fragments
Bacteriophages
DNA Excision Repair
26. A chromosome is present in triplicate in an aneuploid cell.
'The DNA Replication Machine'
Aneuploidy
Males with XYY
Trisomic
27. Offspring that inherit a phenotype that matches one of the parental phenotypes.
Cri du Chat
Wild Type
Parental Types
Extranuclear Genes
28. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.
Bacteriophages
Law of Independent Assortment
Nondisjunction
Lagging Strand
29. A gene located on either sex chromosome. In humans - the term has historically referred specifically to a gene on the X chromosome so fathers pass sex-linked alleles to all of their daughters and none of their sons while mothers can pass sex-linked a
Origins of Replication
Topoisomerase
Inversion
Sex-Linked Gene
30. Adenine doubles bonds thymine and guanine triple bonds cytosine.
Nitrogenous Bases of DNA
Topoisomerase
Aneuploidy
Mismatch Repair
31. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.
The X-O System
Males with XYY
DNA Polymerase
Lagging Strand
32. Occurs when a mismatched nucleotide evades proofreading by DNA polymerase or arise after DNA synthesis is completed.
Mismatch Repair
Signal-strand Binding Protein
Turner Syndrome
DNA Polymerase
33. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister
Extranuclear Genes
Duplication
Males with XYY
The X-O System
34. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s
DNA Structure
Duplication
Semiconservative Model of DNA Replication
Telomeres
35. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a segment within a chromosome reverses.
Inversion
The Z-W System
Extranuclear Genes
Insulin-like Growth Factor 2 (Igf2)
36. The ___________ two genes are - the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency. This process can occasionally break the physical connection between genes on the same chromosome
The X-O System
DNA Ligase
Signal-strand Binding Protein
Farther apart
37. The most common phenotype in a natural population.
Wild Type
The X-O System
Crossing Over
Semiconservative Model of DNA Replication
38. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi
Replication Fork
Crossing Over
The Z-W System
Aneuploidy
39. Predicted by Watson and Crick. Suggests that when a double helix replicates - each of the two daughter molecules will have one old strand - derived from the parent molecule - and one newly made strand.
Semiconservative Model of DNA Replication
Transformation
Turner Syndrome
Conservative Model of DNA Replication
40. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes
The X-O System
The Haplo-diploid System
Polyploidy
Barr body
41. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.
Leading Strand
Genomic Imprinting
The Haplo-diploid System
The Z-W System
42. A method that maps chromosomes and locates genes with respect to chromosomal features - such as stained bands - that can be seen in the microscope. Ultimately show the physical distances between gene loci in DNA nucleotides.
SRY
The Z-W System
Cytogenetic Maps
Mismatch Repair
43. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.
Reciprocal Translocation
Aneuploidy
DNA Polymerase
Sex-Linked Gene
44. An enzyme that joins the sugar-phosphate backbones of the Okazaki fragments - forming a single new DNA strand.
Dispersive Model of DNA Replication
Law of Independent Assortment
DNA Ligase
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
45. Each nucleotide added to a growing DNA strand is a nucleoside triphosphate - which is a sugar and a base with three phosphate groups. The triphosphate monomers used are chemically reactive - partly because their triphosphate tails have an unstable cl
'The DNA Replication Machine'
Genetic Map
Females with XXX
Process of DNA Polymerase Adding a Nucleotide
46. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.
Semiconservative Model of DNA Replication
Females with XXX
Linked Genes
Trisomic
47. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi
Wild Type
Topoisomerase
SRY
The X-Y System
48. The most common type of translocation. A type of change in chromosome structure as a result of some sort of chromosomal breakage. In this - nonhomologous chromosome exchange fragments.
Reciprocal Translocation
The X-Y System
Cytogenetic Maps
Females with XXX
49. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and
Nondisjunction
Nuclease
Replication Fork
Cri du Chat
50. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.
The X-Y System
Duplication
Sex-Linked Gene
Linkage Map
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