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Test your basic knowledge |
GRE Chromosomal And Molecular Basis Of Inheritance
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gre
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science
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biology
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.
Origins of Replication
Males with XYY
Mutant Phenotypes
Topoisomerase
2. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.
Recombinant Types (or Recombinants)
Dispersive Model of DNA Replication
The X-Y System
Topoisomerase
3. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory
Genomic Imprinting
Down Syndrome
Monosomy X (XO)
DNA Excision Repair
4. Alleles of genes on nonhomologous chromosome assort independently during gamete formation.
Duchenne Muscular Dystrophy
Hemophilia
Polyploidy
Law of Independent Assortment
5. Helps relieve strain from the DNA double helix when helicase untwists it at the replication forks - causing tighter twisting ahead of the forks.
Chromosome Theory of Inheritance
Topoisomerase
Telomeres
Signal-strand Binding Protein
6. According to this theory - Mendelian genes have specific loci (positions) on chromosomes - and it is the chromosomes that undergo segregation and independent assortment.
Hemophilia
Insulin-like Growth Factor 2 (Igf2)
Inversion
Chromosome Theory of Inheritance
7. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and
Nuclease
Law of Segregation
Map Units
Helicase
8. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
DNA Excision Repair
Primase
Females with XXX
9. A molecule that binds unpaired DNA strands - after its been separated by helicase - and stabilizes them until they serve as templates for the synthesis of new complementary strands.
Transformation
Females with XXX
Monosomy X (XO)
Signal-strand Binding Protein
10. A change in genotype and phenotype due to the assimilation of external DNA by a cell.
SRY
Transformation
Law of Segregation
Topoisomerase
11. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister
Barr body
Helicase
'The DNA Replication Machine'
Duplication
12. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi
Crossing Over
Males with XYY
Bacteriophages
Mismatch Repair
13. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.
Genetic Map
The X-Y System
Helicase
Parental Types
14. Predicted by Watson and Crick. Suggests that when a double helix replicates - each of the two daughter molecules will have one old strand - derived from the parent molecule - and one newly made strand.
Genetic Map
The Haplo-diploid System
Semiconservative Model of DNA Replication
The Z-W System
15. A result of nondisjuction of sex chromosomes.
Genetic Map
The X-Y System
Turner Syndrome
Inversion
16. One of the first imprinted genes to be identified. Although this growth factor is required for normal prenatal growth - only the paternal allele is expressed.
Hemophilia
Extranuclear Genes
Process of DNA Polymerase Adding a Nucleotide
Insulin-like Growth Factor 2 (Igf2)
17. An enzyme that can start an RNA chain from scratch. Joins RNA nucleotides together one at a time - making a primer complimentary to the template strand at the location where initiation of the new DNA strand will occur.
Aneuploidy
Recombinant Types (or Recombinants)
Primase
Lagging Strand
18. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.
Linked Genes
Wild Type
Deletion
Law of Independent Assortment
19. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe
Law of Segregation
Chronic Myelogenous Leukemia (CML)
Bacteriophages
Aneuploidy
20. An ordered list of the genetic loci along a particular chromosome.
Map Units
Transformation
DNA Ligase
Genetic Map
21. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s
Crossing Over
Wild Type
Telomeres
Inversion
22. A chromosome is present in triplicate in an aneuploid cell.
Law of Independent Assortment
Trisomic
Males with XYY
Aneuploidy
23. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.
Chromosome Theory of Inheritance
Klinefelter Syndrome
Lagging Strand
Monosomy X (XO)
24. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.
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25. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.
Translocation
Nondisjunction
DNA Polymerase
Linkage Map
26. Each nucleotide (monomer) consists of a hydrophobic nitrogenous base (T - A - C - or G) - the sugar dioxyribose - and a phosphate group. The phosphate of one nucleotide is attached to the sugar of the next - making up the 'backbone' of alternating ph
DNA Structure
Linkage Map
Law of Independent Assortment
Reciprocal Translocation
27. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.
Helicase
Map Units
Lagging Strand
Reciprocal Translocation
28. A genetic map based on recombination frequencies.
Law of Segregation
Sex-Linked Gene
Semiconservative Model of DNA Replication
Linkage Map
29. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.
Primer
Females with XXX
Map Units
Deletion
30. Occurs when a mismatched nucleotide evades proofreading by DNA polymerase or arise after DNA synthesis is completed.
Turner Syndrome
Aneuploidy
Helicase
Mismatch Repair
31. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.
Trisomic
Down Syndrome
Nuclease
Monosomy X (XO)
32. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes
The X-O System
Barr body
Recombinant Types (or Recombinants)
Crossing Over
33. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.
Parental Types
Lagging Strand
Hemophilia
Aneuploidy
34. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.
Genomic Imprinting
Primase
Polyploidy
Helicase
35. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.
Linked Genes
Signal-strand Binding Protein
DNA Excision Repair
Translocation
36. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.
Translocation
The Z-W System
Trisomic
Recombinant Types (or Recombinants)
37. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi
Chromosome Theory of Inheritance
Farther apart
Bacteriophages
SRY
38. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.
Extranuclear Genes
Turner Syndrome
Mutant Phenotypes
Recombinant Types (or Recombinants)
39. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje
Map Units
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Chromosome Theory of Inheritance
Hemophilia
40. The system for determining sex in grasshoppers - cockroaches - and some other insects. In these insects - there is only one type of chromosome - the X. Females are XX and males are XO. Sex of the offspring is determined by whether the sperm cell cont
Trisomic
Klinefelter Syndrome
The X-O System
DNA Excision Repair
41. Adenine doubles bonds thymine and guanine triple bonds cytosine.
Primase
Nuclease
Nitrogenous Bases of DNA
Bacteriophages
42. A result of nondisjuction of sex chromosomes. Do not exhibit any well-defined syndrome but tend to be somewhat taller than average.
Males with XYY
Down Syndrome
Monosomic
Genomic Imprinting
43. A method that maps chromosomes and locates genes with respect to chromosomal features - such as stained bands - that can be seen in the microscope. Ultimately show the physical distances between gene loci in DNA nucleotides.
Law of Independent Assortment
DNA Polymerase
Signal-strand Binding Protein
Cytogenetic Maps
44. Can be distinguished from Watson and Crick'S semiconservative model in which the parent molecule somehow re-forms after the process of replication. Proved incorrect and support came out for the semiconservative model.
Conservative Model of DNA Replication
Sex-Linked Gene
Females with XXX
Semiconservative Model of DNA Replication
45. The most common phenotype in a natural population.
Chromosome Theory of Inheritance
Primer
Parental Types
Wild Type
46. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.
Farther apart
Cri du Chat
Replication Fork
Parental Types
47. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa
The X-O System
Primer
Translocation
Mutant Phenotypes
48. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved
Transformation
Helicase
Chronic Myelogenous Leukemia (CML)
DNA Structure
49. The most common type of translocation. A type of change in chromosome structure as a result of some sort of chromosomal breakage. In this - nonhomologous chromosome exchange fragments.
Lagging Strand
Chromosome Theory of Inheritance
Reciprocal Translocation
DNA Polymerase
50. Or phages. Viruses that infect bacteria.
Linked Genes
Bacteriophages
Origins of Replication
SRY
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