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Test your basic knowledge |
GRE Chromosomal And Molecular Basis Of Inheritance
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gre
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science
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biology
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.
Aneuploidy
Deletion
Leading Strand
Barr body
2. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.
Males with XYY
Genomic Imprinting
Law of Independent Assortment
Translocation
3. Occurs when a mismatched nucleotide evades proofreading by DNA polymerase or arise after DNA synthesis is completed.
Duchenne Muscular Dystrophy
Law of Independent Assortment
Turner Syndrome
Mismatch Repair
4. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa
Klinefelter Syndrome
Wild Type
Primer
Okazaki Fragments
5. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.
Polyploidy
Helicase
Nitrogenous Bases of DNA
Map Units
6. The system for determining sex in most species of bees and ants. There are no sex chromosomes in these species - Females develop from fertilized ova and are thus diploid. Males - however - develop from unfertilized ova and are haploid; they have no f
Farther apart
The Haplo-diploid System
Females with XXX
Monosomic
7. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi
Crossing Over
Duplication
Signal-strand Binding Protein
Extranuclear Genes
8. The two alleles for each gene separate during gamete formation.
Replication Fork
DNA Excision Repair
Inversion
Law of Segregation
9. Offspring that inherit a phenotype that matches one of the parental phenotypes.
The Z-W System
Parental Types
Trisomic
Dispersive Model of DNA Replication
10. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s
Mismatch Repair
Deletion
Topoisomerase
Telomeres
11. The most common phenotype in a natural population.
Wild Type
Chronic Myelogenous Leukemia (CML)
Turner Syndrome
The Haplo-diploid System
12. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.
DNA Ligase
Chronic Myelogenous Leukemia (CML)
Hemophilia
The Z-W System
13. Or phages. Viruses that infect bacteria.
Nuclease
Leading Strand
Law of Segregation
Bacteriophages
14. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.
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15. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.
Females with XXX
Signal-strand Binding Protein
Law of Independent Assortment
Linked Genes
16. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe
Klinefelter Syndrome
Law of Independent Assortment
Mismatch Repair
Chronic Myelogenous Leukemia (CML)
17. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.
The X-O System
Map Units
Chromosome Theory of Inheritance
Duchenne Muscular Dystrophy
18. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje
Hemophilia
Inversion
Farther apart
DNA Polymerase
19. A result of nondisjuction of sex chromosomes.
Down Syndrome
Extranuclear Genes
Turner Syndrome
Law of Independent Assortment
20. 1. deletion 2. duplication 3. inversion 4. translocation
The Haplo-diploid System
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Cri du Chat
The X-O System
21. The system for determining sex in grasshoppers - cockroaches - and some other insects. In these insects - there is only one type of chromosome - the X. Females are XX and males are XO. Sex of the offspring is determined by whether the sperm cell cont
Law of Segregation
The X-O System
Law of Independent Assortment
Bacteriophages
22. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.
Recombinant Types (or Recombinants)
Chronic Myelogenous Leukemia (CML)
Reciprocal Translocation
Duplication
23. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.
Semiconservative Model of DNA Replication
The X-O System
Cytogenetic Maps
Lagging Strand
24. A change in genotype and phenotype due to the assimilation of external DNA by a cell.
Parental Types
Bacteriophages
Transformation
Law of Segregation
25. A chromosome is missing in a aneuploid cell.
Insulin-like Growth Factor 2 (Igf2)
Monosomic
Okazaki Fragments
Dispersive Model of DNA Replication
26. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.
Duchenne Muscular Dystrophy
Bacteriophages
The X-Y System
Chromosome Theory of Inheritance
27. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.
Telomeres
Map Units
Telomerase
DNA Excision Repair
28. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister
Duplication
Process of DNA Polymerase Adding a Nucleotide
Mismatch Repair
Telomeres
29. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.
The Z-W System
Mutant Phenotypes
Map Units
Females with XXX
30. According to this theory - Mendelian genes have specific loci (positions) on chromosomes - and it is the chromosomes that undergo segregation and independent assortment.
Monosomic
Law of Independent Assortment
Wild Type
Chromosome Theory of Inheritance
31. An enzyme that joins the sugar-phosphate backbones of the Okazaki fragments - forming a single new DNA strand.
DNA Ligase
Cytogenetic Maps
Lagging Strand
Inversion
32. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.
Aneuploidy
The X-Y System
Cri du Chat
Klinefelter Syndrome
33. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.
Aneuploidy
Transformation
Nuclease
The X-Y System
34. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes
Dispersive Model of DNA Replication
The X-O System
Mismatch Repair
Barr body
35. Genes located on the same chromosome that tend to be inherited together in genetic crosses. These results deviate from those expected from Mendel'S law of independent assortment.
Semiconservative Model of DNA Replication
Linked Genes
The X-Y System
Recombinant Types (or Recombinants)
36. Alleles of genes on nonhomologous chromosome assort independently during gamete formation.
Law of Independent Assortment
DNA Ligase
Deletion
Farther apart
37. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.
Origins of Replication
Polyploidy
Males with XYY
Law of Independent Assortment
38. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved
Down Syndrome
Transformation
Helicase
Aneuploidy
39. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th
Cri du Chat
Extranuclear Genes
DNA Polymerase
Monosomy X (XO)
40. A method that maps chromosomes and locates genes with respect to chromosomal features - such as stained bands - that can be seen in the microscope. Ultimately show the physical distances between gene loci in DNA nucleotides.
Signal-strand Binding Protein
The Z-W System
Cytogenetic Maps
Process of DNA Polymerase Adding a Nucleotide
41. An ordered list of the genetic loci along a particular chromosome.
Farther apart
Genetic Map
Males with XYY
Dispersive Model of DNA Replication
42. A chromosome is present in triplicate in an aneuploid cell.
Conservative Model of DNA Replication
Wild Type
Trisomic
Chronic Myelogenous Leukemia (CML)
43. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.
Dispersive Model of DNA Replication
Telomerase
Replication Fork
Nitrogenous Bases of DNA
44. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.
Nondisjunction
Polyploidy
Primer
Primase
45. The ___________ two genes are - the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency. This process can occasionally break the physical connection between genes on the same chromosome
Recombinant Types (or Recombinants)
Farther apart
Monosomic
DNA Ligase
46. The most common type of translocation. A type of change in chromosome structure as a result of some sort of chromosomal breakage. In this - nonhomologous chromosome exchange fragments.
Inversion
Reciprocal Translocation
'The DNA Replication Machine'
Signal-strand Binding Protein
47. A molecule that binds unpaired DNA strands - after its been separated by helicase - and stabilizes them until they serve as templates for the synthesis of new complementary strands.
DNA Structure
Signal-strand Binding Protein
Wild Type
Process of DNA Polymerase Adding a Nucleotide
48. Helps relieve strain from the DNA double helix when helicase untwists it at the replication forks - causing tighter twisting ahead of the forks.
Primase
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Topoisomerase
Mismatch Repair
49. The strand of DNA that is added on to the template strand one at a time as the fork progresses--with the DNA polymerase nestled in the replication fork. Moves in the 5' to 3' direction.
Trisomic
Extranuclear Genes
Leading Strand
Recombinant Types (or Recombinants)
50. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and
Sex-Linked Gene
Nuclease
Dispersive Model of DNA Replication
Process of DNA Polymerase Adding a Nucleotide
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