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GRE Chromosomal And Molecular Basis Of Inheritance

Subjects : gre, science, biology
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Y-shaped region at the end of a replication bubble where the new strands of DNA are elongating.






2. The most common phenotype in a natural population.






3. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.






4. The two alleles for each gene separate during gamete formation.






5. A molecule that binds unpaired DNA strands - after its been separated by helicase - and stabilizes them until they serve as templates for the synthesis of new complementary strands.






6. Alleles of genes on nonhomologous chromosome assort independently during gamete formation.






7. One of the first imprinted genes to be identified. Although this growth factor is required for normal prenatal growth - only the paternal allele is expressed.






8. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a segment within a chromosome reverses.






9. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.






10. Occurs when a mismatched nucleotide evades proofreading by DNA polymerase or arise after DNA synthesis is completed.






11. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje






12. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.






13. Offspring that inherit a phenotype that matches one of the parental phenotypes.






14. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes






15. A change in genotype and phenotype due to the assimilation of external DNA by a cell.






16. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.






17. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.






18. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi






19. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa






20. A genetic map based on recombination frequencies.






21. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s






22. An enzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells - thus restoring their original length and compensating for the shortening that occurs during DNA replication. Made possible by the presence in the telomerase of a short






23. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and






24. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.






25. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.






26. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.






27. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.






28. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.






29. The system for determining sex in most species of bees and ants. There are no sex chromosomes in these species - Females develop from fertilized ova and are thus diploid. Males - however - develop from unfertilized ova and are haploid; they have no f






30. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.






31. According to this theory - Mendelian genes have specific loci (positions) on chromosomes - and it is the chromosomes that undergo segregation and independent assortment.






32. The strand of DNA that is added on to the template strand one at a time as the fork progresses--with the DNA polymerase nestled in the replication fork. Moves in the 5' to 3' direction.






33. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.






34. The ___________ two genes are - the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency. This process can occasionally break the physical connection between genes on the same chromosome






35. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.






36. A result of nondisjuction of sex chromosomes. In this case - it is the result of an extra X chromosome in a male - producting XXY. People have male sex organs - but the testes are abnormally small and the man is sterile. Some breast enlargement and o






37. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.

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38. The system for determining sex in grasshoppers - cockroaches - and some other insects. In these insects - there is only one type of chromosome - the X. Females are XX and males are XO. Sex of the offspring is determined by whether the sperm cell cont






39. Predicted by Watson and Crick. Suggests that when a double helix replicates - each of the two daughter molecules will have one old strand - derived from the parent molecule - and one newly made strand.






40. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th






41. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.






42. An ordered list of the genetic loci along a particular chromosome.






43. Each nucleotide (monomer) consists of a hydrophobic nitrogenous base (T - A - C - or G) - the sugar dioxyribose - and a phosphate group. The phosphate of one nucleotide is attached to the sugar of the next - making up the 'backbone' of alternating ph






44. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.






45. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.






46. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.






47. Helps relieve strain from the DNA double helix when helicase untwists it at the replication forks - causing tighter twisting ahead of the forks.






48. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.






49. Or phages. Viruses that infect bacteria.






50. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved






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