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GRE Chromosomal And Molecular Basis Of Inheritance

Subjects : gre, science, biology
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The most common phenotype in a natural population.






2. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi






3. Adenine doubles bonds thymine and guanine triple bonds cytosine.






4. A change in genotype and phenotype due to the assimilation of external DNA by a cell.






5. Each nucleotide (monomer) consists of a hydrophobic nitrogenous base (T - A - C - or G) - the sugar dioxyribose - and a phosphate group. The phosphate of one nucleotide is attached to the sugar of the next - making up the 'backbone' of alternating ph






6. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa






7. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.






8. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.






9. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.






10. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi






11. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.






12. An enzyme that can start an RNA chain from scratch. Joins RNA nucleotides together one at a time - making a primer complimentary to the template strand at the location where initiation of the new DNA strand will occur.






13. The two alleles for each gene separate during gamete formation.






14. Genes located on the same chromosome that tend to be inherited together in genetic crosses. These results deviate from those expected from Mendel'S law of independent assortment.






15. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.






16. The system for determining sex in most species of bees and ants. There are no sex chromosomes in these species - Females develop from fertilized ova and are thus diploid. Males - however - develop from unfertilized ova and are haploid; they have no f






17. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.






18. A chromosome is missing in a aneuploid cell.






19. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister






20. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th






21. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe






22. 1. deletion 2. duplication 3. inversion 4. translocation






23. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.






24. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.






25. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.

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26. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.






27. An ordered list of the genetic loci along a particular chromosome.






28. A result of nondisjuction of sex chromosomes. Do not exhibit any well-defined syndrome but tend to be somewhat taller than average.






29. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.






30. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.






31. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.






32. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes






33. An enzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells - thus restoring their original length and compensating for the shortening that occurs during DNA replication. Made possible by the presence in the telomerase of a short






34. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.






35. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.






36. An enzyme that joins the sugar-phosphate backbones of the Okazaki fragments - forming a single new DNA strand.






37. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.






38. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.






39. Or phages. Viruses that infect bacteria.






40. A result of nondisjuction of sex chromosomes. In this case - it is the result of an extra X chromosome in a male - producting XXY. People have male sex organs - but the testes are abnormally small and the man is sterile. Some breast enlargement and o






41. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved






42. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.






43. Each nucleotide added to a growing DNA strand is a nucleoside triphosphate - which is a sugar and a base with three phosphate groups. The triphosphate monomers used are chemically reactive - partly because their triphosphate tails have an unstable cl






44. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and






45. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.






46. The most common type of translocation. A type of change in chromosome structure as a result of some sort of chromosomal breakage. In this - nonhomologous chromosome exchange fragments.






47. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory






48. Offspring that inherit a phenotype that matches one of the parental phenotypes.






49. The ___________ two genes are - the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency. This process can occasionally break the physical connection between genes on the same chromosome






50. A genetic map based on recombination frequencies.







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