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GRE Chromosomal And Molecular Basis Of Inheritance

Subjects : gre, science, biology
Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister






2. Or phages. Viruses that infect bacteria.






3. A result of nondisjuction of sex chromosomes. Do not exhibit any well-defined syndrome but tend to be somewhat taller than average.






4. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.






5. The ___________ two genes are - the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency. This process can occasionally break the physical connection between genes on the same chromosome






6. Each nucleotide added to a growing DNA strand is a nucleoside triphosphate - which is a sugar and a base with three phosphate groups. The triphosphate monomers used are chemically reactive - partly because their triphosphate tails have an unstable cl






7. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.






8. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe






9. A gene located on either sex chromosome. In humans - the term has historically referred specifically to a gene on the X chromosome so fathers pass sex-linked alleles to all of their daughters and none of their sons while mothers can pass sex-linked a






10. A method that maps chromosomes and locates genes with respect to chromosomal features - such as stained bands - that can be seen in the microscope. Ultimately show the physical distances between gene loci in DNA nucleotides.






11. Predicted by Watson and Crick. Suggests that when a double helix replicates - each of the two daughter molecules will have one old strand - derived from the parent molecule - and one newly made strand.






12. An enzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells - thus restoring their original length and compensating for the shortening that occurs during DNA replication. Made possible by the presence in the telomerase of a short






13. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi






14. A result of nondisjuction of sex chromosomes. In this case - it is the result of an extra X chromosome in a male - producting XXY. People have male sex organs - but the testes are abnormally small and the man is sterile. Some breast enlargement and o






15. An ordered list of the genetic loci along a particular chromosome.






16. Adenine doubles bonds thymine and guanine triple bonds cytosine.






17. The most common phenotype in a natural population.






18. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and






19. Genes located on the same chromosome that tend to be inherited together in genetic crosses. These results deviate from those expected from Mendel'S law of independent assortment.






20. Occurs when a mismatched nucleotide evades proofreading by DNA polymerase or arise after DNA synthesis is completed.






21. Offspring that inherit a phenotype that matches one of the parental phenotypes.






22. Each nucleotide (monomer) consists of a hydrophobic nitrogenous base (T - A - C - or G) - the sugar dioxyribose - and a phosphate group. The phosphate of one nucleotide is attached to the sugar of the next - making up the 'backbone' of alternating ph






23. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.






24. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.

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25. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.






26. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.






27. One of the first imprinted genes to be identified. Although this growth factor is required for normal prenatal growth - only the paternal allele is expressed.






28. The system for determining sex in grasshoppers - cockroaches - and some other insects. In these insects - there is only one type of chromosome - the X. Females are XX and males are XO. Sex of the offspring is determined by whether the sperm cell cont






29. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.






30. A result of nondisjuction of sex chromosomes.






31. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.






32. An enzyme that joins the sugar-phosphate backbones of the Okazaki fragments - forming a single new DNA strand.






33. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes






34. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje






35. Y-shaped region at the end of a replication bubble where the new strands of DNA are elongating.






36. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.






37. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s






38. Helps relieve strain from the DNA double helix when helicase untwists it at the replication forks - causing tighter twisting ahead of the forks.






39. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.






40. A change in genotype and phenotype due to the assimilation of external DNA by a cell.






41. An enzyme that can start an RNA chain from scratch. Joins RNA nucleotides together one at a time - making a primer complimentary to the template strand at the location where initiation of the new DNA strand will occur.






42. The two alleles for each gene separate during gamete formation.






43. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.






44. Alleles of genes on nonhomologous chromosome assort independently during gamete formation.






45. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi






46. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.






47. A genetic map based on recombination frequencies.






48. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th






49. A molecule that binds unpaired DNA strands - after its been separated by helicase - and stabilizes them until they serve as templates for the synthesis of new complementary strands.






50. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.