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GRE Chromosomal And Molecular Basis Of Inheritance
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gre
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science
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biology
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. A result of nondisjuction of sex chromosomes. In this case - it is the result of an extra X chromosome in a male - producting XXY. People have male sex organs - but the testes are abnormally small and the man is sterile. Some breast enlargement and o
Law of Segregation
Duchenne Muscular Dystrophy
Klinefelter Syndrome
Transformation
2. Or phages. Viruses that infect bacteria.
Bacteriophages
Farther apart
'The DNA Replication Machine'
Linked Genes
3. Alleles of genes on nonhomologous chromosome assort independently during gamete formation.
Telomeres
Process of DNA Polymerase Adding a Nucleotide
Law of Independent Assortment
Cri du Chat
4. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.
Translocation
The X-Y System
Parental Types
DNA Polymerase
5. 1. deletion 2. duplication 3. inversion 4. translocation
Bacteriophages
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Dispersive Model of DNA Replication
Linkage Map
6. The strand of DNA that is added on to the template strand one at a time as the fork progresses--with the DNA polymerase nestled in the replication fork. Moves in the 5' to 3' direction.
Inversion
Leading Strand
Lagging Strand
The Haplo-diploid System
7. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.
Deletion
DNA Ligase
Mutant Phenotypes
Translocation
8. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved
DNA Polymerase
Cri du Chat
Replication Fork
Helicase
9. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s
Wild Type
Replication Fork
Telomeres
Down Syndrome
10. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.
Okazaki Fragments
Cytogenetic Maps
Nondisjunction
DNA Polymerase
11. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.
Genetic Map
Law of Independent Assortment
Monosomy X (XO)
Linkage Map
12. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.
Conservative Model of DNA Replication
Down Syndrome
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Polyploidy
13. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.
Map Units
Mutant Phenotypes
Males with XYY
Nondisjunction
14. A gene located on either sex chromosome. In humans - the term has historically referred specifically to a gene on the X chromosome so fathers pass sex-linked alleles to all of their daughters and none of their sons while mothers can pass sex-linked a
Sex-Linked Gene
Telomeres
Down Syndrome
Klinefelter Syndrome
15. A result of nondisjuction of sex chromosomes.
The Haplo-diploid System
Helicase
Turner Syndrome
Primase
16. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.
Law of Independent Assortment
Cri du Chat
Genomic Imprinting
Females with XXX
17. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.
Genomic Imprinting
Klinefelter Syndrome
Recombinant Types (or Recombinants)
Bacteriophages
18. An enzyme that can start an RNA chain from scratch. Joins RNA nucleotides together one at a time - making a primer complimentary to the template strand at the location where initiation of the new DNA strand will occur.
Insulin-like Growth Factor 2 (Igf2)
Linkage Map
Crossing Over
Primase
19. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.
Chronic Myelogenous Leukemia (CML)
Aneuploidy
Monosomic
Recombinant Types (or Recombinants)
20. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister
Duplication
Okazaki Fragments
Transformation
Linkage Map
21. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory
Nuclease
Origins of Replication
Down Syndrome
Primer
22. Can be distinguished from Watson and Crick'S semiconservative model in which the parent molecule somehow re-forms after the process of replication. Proved incorrect and support came out for the semiconservative model.
Law of Segregation
Conservative Model of DNA Replication
Nitrogenous Bases of DNA
'The DNA Replication Machine'
23. An enzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells - thus restoring their original length and compensating for the shortening that occurs during DNA replication. Made possible by the presence in the telomerase of a short
Chronic Myelogenous Leukemia (CML)
Telomerase
Topoisomerase
The X-Y System
24. A molecule that binds unpaired DNA strands - after its been separated by helicase - and stabilizes them until they serve as templates for the synthesis of new complementary strands.
Aneuploidy
Transformation
Signal-strand Binding Protein
Klinefelter Syndrome
25. Genes located on the same chromosome that tend to be inherited together in genetic crosses. These results deviate from those expected from Mendel'S law of independent assortment.
Replication Fork
Origins of Replication
Linked Genes
Inversion
26. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje
Hemophilia
Mismatch Repair
Map Units
Cri du Chat
27. One of the first imprinted genes to be identified. Although this growth factor is required for normal prenatal growth - only the paternal allele is expressed.
Insulin-like Growth Factor 2 (Igf2)
Linked Genes
Topoisomerase
Primer
28. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and
Primase
Nuclease
Reciprocal Translocation
DNA Structure
29. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.
Lagging Strand
DNA Structure
Translocation
Nuclease
30. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.
Males with XYY
Origins of Replication
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Telomeres
31. Each nucleotide added to a growing DNA strand is a nucleoside triphosphate - which is a sugar and a base with three phosphate groups. The triphosphate monomers used are chemically reactive - partly because their triphosphate tails have an unstable cl
Chromosome Theory of Inheritance
SRY
Process of DNA Polymerase Adding a Nucleotide
Trisomic
32. A result of nondisjuction of sex chromosomes. Do not exhibit any well-defined syndrome but tend to be somewhat taller than average.
Linkage Map
Replication Fork
Parental Types
Males with XYY
33. Y-shaped region at the end of a replication bubble where the new strands of DNA are elongating.
Replication Fork
Hemophilia
Trisomic
Recombinant Types (or Recombinants)
34. The most common phenotype in a natural population.
Signal-strand Binding Protein
Law of Segregation
Wild Type
Nitrogenous Bases of DNA
35. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.
Nuclease
Recombinant Types (or Recombinants)
The X-Y System
Linkage Map
36. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.
DNA Structure
DNA Excision Repair
Monosomy X (XO)
Translocation
37. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.
Males with XYY
Law of Independent Assortment
Translocation
The Z-W System
38. Predicted by Watson and Crick. Suggests that when a double helix replicates - each of the two daughter molecules will have one old strand - derived from the parent molecule - and one newly made strand.
The X-O System
Semiconservative Model of DNA Replication
Trisomic
Klinefelter Syndrome
39. The system for determining sex in most species of bees and ants. There are no sex chromosomes in these species - Females develop from fertilized ova and are thus diploid. Males - however - develop from unfertilized ova and are haploid; they have no f
Mismatch Repair
The Haplo-diploid System
Law of Segregation
Conservative Model of DNA Replication
40. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.
Mutant Phenotypes
Crossing Over
Hemophilia
Semiconservative Model of DNA Replication
41. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.
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42. The two alleles for each gene separate during gamete formation.
Law of Segregation
Telomeres
Barr body
Extranuclear Genes
43. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.
Telomeres
Reciprocal Translocation
Translocation
Duchenne Muscular Dystrophy
44. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe
Semiconservative Model of DNA Replication
Chronic Myelogenous Leukemia (CML)
SRY
Mismatch Repair
45. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.
DNA Polymerase
Okazaki Fragments
DNA Ligase
Hemophilia
46. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.
Females with XXX
The Z-W System
The X-O System
Dispersive Model of DNA Replication
47. According to this theory - Mendelian genes have specific loci (positions) on chromosomes - and it is the chromosomes that undergo segregation and independent assortment.
Okazaki Fragments
Chromosome Theory of Inheritance
Recombinant Types (or Recombinants)
Chronic Myelogenous Leukemia (CML)
48. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi
Crossing Over
Monosomic
Translocation
Lagging Strand
49. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa
Deletion
Chromosome Theory of Inheritance
Primer
DNA Polymerase
50. An enzyme that joins the sugar-phosphate backbones of the Okazaki fragments - forming a single new DNA strand.
DNA Ligase
Monosomic
Monosomy X (XO)
Law of Independent Assortment
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