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GRE Chromosomal And Molecular Basis Of Inheritance

Subjects : gre, science, biology
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  • Answer 50 questions in 15 minutes.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. According to this theory - Mendelian genes have specific loci (positions) on chromosomes - and it is the chromosomes that undergo segregation and independent assortment.






2. The strand of DNA that is added on to the template strand one at a time as the fork progresses--with the DNA polymerase nestled in the replication fork. Moves in the 5' to 3' direction.






3. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.






4. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.






5. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.






6. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa






7. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.






8. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.






9. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.






10. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.






11. Genes located on the same chromosome that tend to be inherited together in genetic crosses. These results deviate from those expected from Mendel'S law of independent assortment.






12. Y-shaped region at the end of a replication bubble where the new strands of DNA are elongating.






13. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a segment within a chromosome reverses.






14. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi






15. Occurs when a mismatched nucleotide evades proofreading by DNA polymerase or arise after DNA synthesis is completed.






16. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.






17. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.


18. The two alleles for each gene separate during gamete formation.






19. The most common phenotype in a natural population.






20. The system for determining sex in grasshoppers - cockroaches - and some other insects. In these insects - there is only one type of chromosome - the X. Females are XX and males are XO. Sex of the offspring is determined by whether the sperm cell cont






21. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and






22. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.






23. A molecule that binds unpaired DNA strands - after its been separated by helicase - and stabilizes them until they serve as templates for the synthesis of new complementary strands.






24. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe






25. 1. deletion 2. duplication 3. inversion 4. translocation






26. The most common type of translocation. A type of change in chromosome structure as a result of some sort of chromosomal breakage. In this - nonhomologous chromosome exchange fragments.






27. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.






28. One of the first imprinted genes to be identified. Although this growth factor is required for normal prenatal growth - only the paternal allele is expressed.






29. An ordered list of the genetic loci along a particular chromosome.






30. A chromosome is missing in a aneuploid cell.






31. An enzyme that joins the sugar-phosphate backbones of the Okazaki fragments - forming a single new DNA strand.






32. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.






33. Adenine doubles bonds thymine and guanine triple bonds cytosine.






34. A change in genotype and phenotype due to the assimilation of external DNA by a cell.






35. A compact object that is the inactive X in each cell of a female. Although female mammals inherit two X chromosomes - one becomes almost completely inactivated during embryonic development and lies along the inside of the nuclear envelope. Most genes






36. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister






37. A chromosome is present in triplicate in an aneuploid cell.






38. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.






39. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.






40. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje






41. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved






42. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s






43. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th






44. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.






45. Each nucleotide (monomer) consists of a hydrophobic nitrogenous base (T - A - C - or G) - the sugar dioxyribose - and a phosphate group. The phosphate of one nucleotide is attached to the sugar of the next - making up the 'backbone' of alternating ph






46. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.






47. A method that maps chromosomes and locates genes with respect to chromosomal features - such as stained bands - that can be seen in the microscope. Ultimately show the physical distances between gene loci in DNA nucleotides.






48. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory






49. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.






50. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.