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GRE Chromosomal And Molecular Basis Of Inheritance

Subjects : gre, science, biology
Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. A result of nondisjuction of sex chromosomes. Females are healthy and cannot be distinguished phenotypically from other females.






2. A genetic map based on recombination frequencies.






3. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje






4. A chromosome is missing in a aneuploid cell.






5. A change in genotype and phenotype due to the assimilation of external DNA by a cell.






6. The system for determining sex in grasshoppers - cockroaches - and some other insects. In these insects - there is only one type of chromosome - the X. Females are XX and males are XO. Sex of the offspring is determined by whether the sperm cell cont






7. Alleles of genes on nonhomologous chromosome assort independently during gamete formation.






8. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.






9. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory






10. The various proteins that participate in DNA replication actually form a single large complex since many of the protein-protein interactions actually facilitate the efficiency of the machine as a whole.

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11. A result of nondisjuction of sex chromosomes. Do not exhibit any well-defined syndrome but tend to be somewhat taller than average.






12. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi






13. An ordered list of the genetic loci along a particular chromosome.






14. A method that maps chromosomes and locates genes with respect to chromosomal features - such as stained bands - that can be seen in the microscope. Ultimately show the physical distances between gene loci in DNA nucleotides.






15. According to this theory - Mendelian genes have specific loci (positions) on chromosomes - and it is the chromosomes that undergo segregation and independent assortment.






16. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.






17. Occurs when a mismatched nucleotide evades proofreading by DNA polymerase or arise after DNA synthesis is completed.






18. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th






19. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.






20. Predicted by Watson and Crick. Suggests that when a double helix replicates - each of the two daughter molecules will have one old strand - derived from the parent molecule - and one newly made strand.






21. Offspring that inherit a phenotype that matches one of the parental phenotypes.






22. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.






23. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.






24. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.






25. A gene located on either sex chromosome. In humans - the term has historically referred specifically to a gene on the X chromosome so fathers pass sex-linked alleles to all of their daughters and none of their sons while mothers can pass sex-linked a






26. Genes located on the same chromosome that tend to be inherited together in genetic crosses. These results deviate from those expected from Mendel'S law of independent assortment.






27. An enzyme that untwists the double helix at the replication forks - separating the two parental strands and making them available as template strands. This untwisting causes tighter twisting and strain ahead of the replication forks which is relieved






28. Can be distinguished from Watson and Crick'S semiconservative model in which the parent molecule somehow re-forms after the process of replication. Proved incorrect and support came out for the semiconservative model.






29. The strand of DNA that is added on to the template strand one at a time as the fork progresses--with the DNA polymerase nestled in the replication fork. Moves in the 5' to 3' direction.






30. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.






31. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.






32. The short initial nucleotide chain put in place before DNA polymerase begins synthesizing in the 5' to 3' direction. May consist of either DNA or RNA. In initiating the replication of cellular DNA - the primer is a short stretch of RNA with an availa






33. A molecule that binds unpaired DNA strands - after its been separated by helicase - and stabilizes them until they serve as templates for the synthesis of new complementary strands.






34. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.






35. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.






36. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi






37. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s






38. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.






39. An enzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells - thus restoring their original length and compensating for the shortening that occurs during DNA replication. Made possible by the presence in the telomerase of a short






40. Each nucleotide added to a growing DNA strand is a nucleoside triphosphate - which is a sugar and a base with three phosphate groups. The triphosphate monomers used are chemically reactive - partly because their triphosphate tails have an unstable cl






41. Or phages. Viruses that infect bacteria.






42. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.






43. The system for determining sex in birds - some fishes - and some insects. The sex chromosome present in the ovum determines the sex of offspring. The sex chromosomes are designated Z and W. Females are ZW and males are ZZ.






44. Y-shaped region at the end of a replication bubble where the new strands of DNA are elongating.






45. A chromosome is present in triplicate in an aneuploid cell.






46. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.






47. A result of nondisjuction of sex chromosomes.






48. The most common phenotype in a natural population.






49. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.






50. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.