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Test your basic knowledge |
GRE Chromosomal And Molecular Basis Of Inheritance
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Subjects
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gre
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science
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biology
Instructions:
Answer 50 questions in 15 minutes.
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study here
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment repeats a segment. In some cases - if meiosis is in progress - a deleted fragment may become as an extra segment to a sister
Monosomic
Duplication
Sex-Linked Gene
Trisomic
2. Nucleotide sequences found in eukaryotic chromosomal DNA that make up for the fact that DNA polymerases cannot replicate the ends of DNA strands since there is no 3' end there. Do not contain genes but rather the DNA has multiple repetitions of one s
Telomeres
Turner Syndrome
Genomic Imprinting
DNA Polymerase
3. An enzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells - thus restoring their original length and compensating for the shortening that occurs during DNA replication. Made possible by the presence in the telomerase of a short
Barr body
Monosomy X (XO)
Law of Segregation
Telomerase
4. DNA repair that involves cleaving by nuclease and gap refilling by DNA polymerase and ligase.
Nitrogenous Bases of DNA
Map Units
SRY
DNA Excision Repair
5. The sex-determining region of Y. The gene on the Y chromosome required for the development of testes. In the absence of SRY - the gonads develop into ovaries. SRY is simply the trigger and other genes on the Y chromosome are required for normal testi
SRY
Genetic Map
Turner Syndrome
Conservative Model of DNA Replication
6. Helps in repairing and proofreading DNA. An enzyme that cuts out a segment of the strand of DNA containing damage - creating a gap which is filled in with nucleotides properly paired with the nucleotides in the undamaged strand by DNA polymerase and
Bacteriophages
The X-Y System
Nuclease
Primer
7. In this - all four strands of DNA following replication have a mixture of old and new DNA. Proved incorrect and support came out for the semiconservative model.
Signal-strand Binding Protein
Dispersive Model of DNA Replication
Cri du Chat
The Z-W System
8. A sex-linked recessive disorder. Defined by the absence of one or more of the proteins required for blood clotting. When injured - people with this disease have prolonged bleeding because a firm clot is slow to form. Patients receive intravenous inje
Klinefelter Syndrome
Telomerase
Hemophilia
Process of DNA Polymerase Adding a Nucleotide
9. Phenotypically female but are sterile because their sex organs do not mature. When provided with estrogen replacement therapy - girls with Turners develop secondary sex characteristics.
Sex-Linked Gene
Chromosome Theory of Inheritance
Monosomy X (XO)
Mismatch Repair
10. A method that maps chromosomes and locates genes with respect to chromosomal features - such as stained bands - that can be seen in the microscope. Ultimately show the physical distances between gene loci in DNA nucleotides.
Nondisjunction
Hemophilia
Cytogenetic Maps
Genetic Map
11. Traits that are alternatives to the wild type because they are due to alleles assumed to have arisen as changes - or mutations - in the wild-type allele.
The X-O System
Mutant Phenotypes
Linkage Map
Chromosome Theory of Inheritance
12. A human sex-linked disorder. A disease characterized by progressive weakening of the muscles and loss of coordination. Affected individuals rarely live past their early 20s. A result of the absence of a key muscle protein called dystrophin.
Polyploidy
Chronic Myelogenous Leukemia (CML)
Duchenne Muscular Dystrophy
Chromosome Theory of Inheritance
13. Disorder caused by structurally altered chromosomes - specifically a deletion in chromosome 5. A child born with this deletion is mentally retarded - has a small head with unusual facial features - and has a cry that sounds like the mewing of a cat.
Cri du Chat
The X-Y System
Primase
Insulin-like Growth Factor 2 (Igf2)
14. Y-shaped region at the end of a replication bubble where the new strands of DNA are elongating.
Law of Independent Assortment
Semiconservative Model of DNA Replication
'The DNA Replication Machine'
Replication Fork
15. An enzyme that catalyzes elongation of new DNA at a replication fork. As individual nucleotides align with complementary nucleotides along a template strand of DNA - DNA polymerase adds them to the growing end of the new DNA strand one by one.
Polyploidy
DNA Polymerase
Barr body
The X-O System
16. A gene located on either sex chromosome. In humans - the term has historically referred specifically to a gene on the X chromosome so fathers pass sex-linked alleles to all of their daughters and none of their sons while mothers can pass sex-linked a
Inversion
Telomeres
DNA Excision Repair
Sex-Linked Gene
17. One of the first imprinted genes to be identified. Although this growth factor is required for normal prenatal growth - only the paternal allele is expressed.
Chronic Myelogenous Leukemia (CML)
Insulin-like Growth Factor 2 (Igf2)
Farther apart
Monosomic
18. Special site on a DNA molecule which replication begins. Indicated by a specific sequence of nucleotides.
Origins of Replication
Klinefelter Syndrome
Mutant Phenotypes
The Haplo-diploid System
19. The ___________ two genes are - the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency. This process can occasionally break the physical connection between genes on the same chromosome
Linkage Map
Farther apart
Klinefelter Syndrome
Topoisomerase
20. Helps relieve strain from the DNA double helix when helicase untwists it at the replication forks - causing tighter twisting ahead of the forks.
Polyploidy
Topoisomerase
Nondisjunction
Genomic Imprinting
21. A way of expressing distances between genes - defining one map unit as equivalent to a 1% recombination frequency.
Recombinant Types (or Recombinants)
Trisomic
Map Units
'The DNA Replication Machine'
22. The most common phenotype in a natural population.
Females with XXX
Wild Type
Replication Fork
Recombinant Types (or Recombinants)
23. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment lacking a centromere is lost. The affected chromosome is then missing certain genes.
Mismatch Repair
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Farther apart
Deletion
24. An aneuploid condition. Usually the result of an extra chromosome 21 so that each body cell has a total of 47 chromosomes. Also termed trisomy 21. Includes characteristic facial feature - short stature - heart defects - susceptibility to respiratory
Translocation
SRY
Down Syndrome
Bacteriophages
25. Can be distinguished from Watson and Crick'S semiconservative model in which the parent molecule somehow re-forms after the process of replication. Proved incorrect and support came out for the semiconservative model.
The Z-W System
Linked Genes
Conservative Model of DNA Replication
'The DNA Replication Machine'
26. The system for determining sex in grasshoppers - cockroaches - and some other insects. In these insects - there is only one type of chromosome - the X. Females are XX and males are XO. Sex of the offspring is determined by whether the sperm cell cont
Telomeres
Okazaki Fragments
The X-O System
Farther apart
27. An abnormal number of a particular chromosome. A condition that arises when an aberrant gamete (a result of nondisjunction) unites with a normal one at fertilization.
Linkage Map
Chronic Myelogenous Leukemia (CML)
Aneuploidy
The Haplo-diploid System
28. Offspring that have new combinations of their parent'S phenotypes. When 50% of offspring are recombinants - geneticists say that there is a 50% frequency of recombination and is observed for any two genes that are located on different chromosomes.
The X-Y System
Farther apart
Recombinant Types (or Recombinants)
Signal-strand Binding Protein
29. A occasional mishap that may occur during meiosis in which the members of a pair of chromosomes do not move apart properly during meiosis I or sister chromatids fail to separate during meiosis II.
Duplication
Nondisjunction
Origins of Replication
Cri du Chat
30. Genes located in organelles in the cytoplasm. Mitochondria and plastids contain small circular DNA molecules that carry genes coding for proteins and RNA and do not display Mendelian inheritance. For example - almost all the mitochondria come from th
Topoisomerase
Extranuclear Genes
Leading Strand
Crossing Over
31. Each nucleotide added to a growing DNA strand is a nucleoside triphosphate - which is a sugar and a base with three phosphate groups. The triphosphate monomers used are chemically reactive - partly because their triphosphate tails have an unstable cl
Extranuclear Genes
Recombinant Types (or Recombinants)
The X-O System
Process of DNA Polymerase Adding a Nucleotide
32. A result of nondisjuction of sex chromosomes.
The Z-W System
Farther apart
Sex-Linked Gene
Turner Syndrome
33. The process that accounts for the recombination of linked genes. Occurs while replicated homologous chromosomes are pair during prophase of meiosis I - one maternal chromatid and one paternal chromatid break at corresponding points and then are rejoi
Lagging Strand
Crossing Over
4 Type of Changes in Chromosome Structure as a Result of Chromosome Breakage
Barr body
34. Offspring that inherit a phenotype that matches one of the parental phenotypes.
Okazaki Fragments
Parental Types
Monosomy X (XO)
Nuclease
35. Adenine doubles bonds thymine and guanine triple bonds cytosine.
Telomeres
Duchenne Muscular Dystrophy
Nitrogenous Bases of DNA
Signal-strand Binding Protein
36. A chromosome is missing in a aneuploid cell.
Origins of Replication
Crossing Over
Chromosome Theory of Inheritance
Monosomic
37. Predicted by Watson and Crick. Suggests that when a double helix replicates - each of the two daughter molecules will have one old strand - derived from the parent molecule - and one newly made strand.
Semiconservative Model of DNA Replication
The Z-W System
Telomerase
Barr body
38. The new strand of DNA moving in the direction away from the replication fork. Synthesized as a series of segments in contrast to the leading strand that elongates continuously.
Signal-strand Binding Protein
Topoisomerase
Sex-Linked Gene
Lagging Strand
39. A change in genotype and phenotype due to the assimilation of external DNA by a cell.
Replication Fork
The X-O System
DNA Excision Repair
Transformation
40. Traits that depend on which parent passed along the alleles for those traits. An exception to the display of Mendelian inheritance.
Telomeres
Law of Segregation
Genomic Imprinting
Duplication
41. A cancer implicated by chromosomal translocations. The exchange of a larger portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shorted - easily recognized chromosome 22 - called the Philadelphia chromosome. Affe
Klinefelter Syndrome
Origins of Replication
Hemophilia
Chronic Myelogenous Leukemia (CML)
42. An enzyme that can start an RNA chain from scratch. Joins RNA nucleotides together one at a time - making a primer complimentary to the template strand at the location where initiation of the new DNA strand will occur.
The X-Y System
Trisomic
Telomerase
Primase
43. The system for determining sex in most species of bees and ants. There are no sex chromosomes in these species - Females develop from fertilized ova and are thus diploid. Males - however - develop from unfertilized ova and are haploid; they have no f
Law of Independent Assortment
Turner Syndrome
The Haplo-diploid System
Mutant Phenotypes
44. The most common type of translocation. A type of change in chromosome structure as a result of some sort of chromosomal breakage. In this - nonhomologous chromosome exchange fragments.
Telomeres
Reciprocal Translocation
Semiconservative Model of DNA Replication
Conservative Model of DNA Replication
45. A type of change in chromosome structure as a result of some sort of chromosomal breakage. Occurs when a chromosomal fragment breaks and joins a nonhomologous chromosome.
Translocation
Sex-Linked Gene
Genetic Map
The X-Y System
46. Or phages. Viruses that infect bacteria.
Bacteriophages
Leading Strand
Mutant Phenotypes
Duplication
47. The segments of the lagging strand that get added to the template strand. The segments get joined together by DNA ligase.
Conservative Model of DNA Replication
Okazaki Fragments
Down Syndrome
Nondisjunction
48. The general term for a chromosomal alteration in which an organism has more than two complete chromosome sets. There are more specific terms like triploidy (3n) and tetraploidy (4n) indicating 3 or 4 chromosomal sets - respectively.
Primase
Polyploidy
Telomeres
Sex-Linked Gene
49. Each nucleotide (monomer) consists of a hydrophobic nitrogenous base (T - A - C - or G) - the sugar dioxyribose - and a phosphate group. The phosphate of one nucleotide is attached to the sugar of the next - making up the 'backbone' of alternating ph
DNA Structure
Klinefelter Syndrome
Mismatch Repair
The X-O System
50. The mammalian system for determining sex. The sex of the offspring depends on whether the sperm cell contains an X chromosome or a Y.
The X-Y System
Farther apart
Klinefelter Syndrome
Hemophilia