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MCAT Prep - 2

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1. cholinergic receptors: NICTONIC and MUSCARINIC Nicotinic: neuromuscular effectors (ionotropic) Muscarinic: PARA effectors (GPCRs) Adrenergic: SYMP effectors (GPCRs)
**only para effectors have muscarinic receptors; symp effectors are adrenergic (epi - norepi); **neuromuscular junction uses nicotinic receptors
Secreted by implanted egg; HCG prevents degeneration of the corpus luteum; HCG in blood/urine is first sign of pregnancy
HCl; secreted by parietal cells under stim by gastrin
REABSORPTION: draws off water and ions - increases osmolarity of the medulla while slightly lowering osmolarity of the filtrate -->medulla must have hi osmolarity in order to concentrate urine at collecting duct (final step in nephron)

2. liver receives blood from...
Growth 1 (G1) phase: STRUCTURAL ProteinS - ENZYMES; This is a very active period - where the cell synthesizes its vast array of proteins - including the enzymes and structural proteins it will need for growth. In G1 stage each of the chromosomes cons
Stomach - sm intest - spleen - pancreas from the hepatic portal vein...all blood that passes thru liver go thru flattened spaces called the ***hepatic sinusoids -->hepatic vein --->vena cava
- enterocytes w/ *microvilli brush border*: membrane - bound digestive enzymes for carbs - fats - nucleic acids - goblet cells: secrete mucous - Deep between villi are the intestinal exocrine glands - the crypts of Lieberkuhn - which secrete pH 7.6 i
Follicular phase: primary - secondary - ovulation (1 week) luteal phase: ovulation - thickening of uterine lining w/corpus luteum secretion - corpus luteum degrades (2 weeks) flow: shedding of uterine lining (4 days)

3. FSH - LH - HCG - inhibin are...
Carry signals to musc OR Gland
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics
Peptides
Polysaccharides w/proteoglycans attached = glycosaminoglycans; often give pliability

4. oxytocin
HCl; secreted by parietal cells under stim by gastrin
Posterior pituitary hormone; acts on uterus - mammary glands; causes uterine contractions - milk ejection
On the chyme exiting the stomach and entering duodenum thru the pyloric sphincter
Inner lining of circulatory system

5. when cells hit their limit for prot storage...
Glycosaminoglycans - prots - AAs - lipids
After morula - with blastocyst (+8 cell count)--->totipotent to embryonic stem cell and so on
Increases surface area of food ball (bolus)
AAs can be burned for energy or converted to fat for storage

6. After meiosis II - Male

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7. examples of different cavities... (compartments for viscera)
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
Contain capillary network - lymph vessels (lacteals)
CARB- Digesting: dextrinase (polysachs produced by hydrolysis of starch) - maltase (glucose - glucose) - sucrase (glucose - fructose) - lactase (galactose - glucose) - Protein- Digesting: peptidases - NUCLEOTIDE- Digesting: nucleosidases
pericardial cavity - pleural cavity (contains lungs) - peritoneal cavity (abdominal)

8. FLAT PG: hGH aka somatotropin
Called a tract in the CNS; bundling together of axons/dendrites thru which many diff signals pass; many many neurons are bundled together into a single nerve
Peptide; stims growth of nearly all cell of body; all other anterior pituitary horms have specific targets; upregulates anabolic pathways; use of fat for energy goes up (fat - burning); increases AA transport across cell membrane (nutrient uptake)
Injury that does not sever SC (causes deep lesion from back - front) might cause loss of feeling without full loss of motion
Glands w/ducts: Exocrine glands

9. What kind of cells make up epithel tiss of stom - then sm intest?
Albumin increases osmolarity of blood; increases osmotic pressure
It is the animal counterpart of starch; it is more highly- branched - thus releases more glucose monomers upon repeated hydrolysis than starch
Stom= G cells (gastrin) - parietal (oxyntic); chief (peptic); mucous cells (hi ER - Golgi to make sticky glycoprots) - sm intest= enterocytes (w/brush border of maltase - sucrase - lactase - dextrinase; peptidase; lipase; nucleases); goblet cells (mu
Fat is insoluble in blood and requires a carrier like lipoproteins (vLDL...HDL) or albumins; ...vLDL has hi triglycerides - hi cholesterol

10. What is the adventitia?
Outermost layer of blood vessel
Alpha 1-4 and 1-6 (branching) glycosidic linkages
Alpha cells; stims gluconeogenesis in liver; acts via cAMP second messenger
RBCs - large proteins; What does enter is called the filtrate

11. keep in mind that enterocyte is like a regular euk cell
Estrogen: steroid; stims LH in luteal surge; causes growth of female sex organs progesterone: prepares/maintains uterus for pregnancy
Somatic sensory = dorsal root ganglia (outside spinal cord); somatic effector = ventral horns of spinal cord
***starting with adipose tiss: FFAs are transported in the blood by albumin (major component of blood plasma); one albumin typically carries three fatty acid molecules but can hold up to 30 FAs
Has memb - bound organelles - etc...

12. The EYE
Focuses light thru the vitreous humor onto retina; acts as a converging lens (image is real - inverted)
Pancreatic duct (made of acinar cells?)
Abdominal cavity - which is coated in serous fluid
Comes into play in the large intestine - where vitamin b12 is absorbed w/help of E. coli; thus; must travel thru bloodstream to large intestine

13. Determination is different than differentiation
Spinal cord ventral horns; somatic motor neurons use acetylcholine for NTs (voluntary)
Below hypothalamus
Stores blood: when expanded liver serves as blood reservoir for body - filters blood: Kupfer cells phagocytize bacteria picked up from intestines - destroys bad RBCs: also done by Kupfer cells - detoxifies blood: detoxified chemicals are excreted eit
Determination is a pre - programmed fate - differentiation is the actual materialization of that fate

14. Morula (...totipotent)
Zygote (morula) composed of eight or more cells; All cells at this stage are TOTipOTENT STEM Cells: do not grow - form by cleavage
Di - tri - peptides; inside enterocytes are hydrolyzed to amino acids
Normally contracted
AAs enter bloodstream for uptake by all cells (esp liver). If intracellular prot conc is at max AAs can be converted to fats or glucose via gluconeogenesis. Byproduct of gluconeo is ammonia --->urea.

15. Does bile digest fat?
Peptide; stims growth of nearly all cell of body; all other anterior pituitary horms have specific targets; upregulates anabolic pathways; use of fat for energy goes up (fat - burning); increases AA transport across cell membrane (nutrient uptake)
**NO*** lipase digests fat; no bonds broken by bile; only opens up more SA for lipase
Determination is a pre - programmed fate - differentiation is the actual materialization of that fate
Gall bladder - pancreatic secretions increase - arrive via ampulla of vater (duct glands); insulin secretion increases (fed state; ductless glands)

16. When 'coumadin targets liver enzymes to act as anticoagulant'...
Adrenal gland -- AC: steroids (cortisol - aldosterone); AM: catecholamines (epi - norepi); Islets of langerhans: peptides (insulin/glucagon) ANTAGONISTS: calcitonin (thyroid - peptide lowers Ca in blood); parathyroid hormone - peptide - vitamin D pat
It targets liver conc of prothrombin - fibrinogen etc
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
Prophase II: no crossing over b/c there are no homologous chromosomes; nuclear envelope dissolves Metaphase II: chromosomes line up at metaphase plate Anaphase II: sister chromatids separate - migrate to opp poles Telophase II: nuclear envelope reap

17. energy source of neurons
PH 6.0; this accomplished by pancreatic secretion of bicarbonate which ups pH
At metaphase II of meiosis II (halted during reductional division); if fertilized - process continues toward haploid gamete
Di - tri - peptides; inside enterocytes are hydrolyzed to amino acids
Glucose and ketone bodies (not from glycogen stores)

18. FLAT PG: TSH aka thyrotropin
Determination is a pre - programmed fate - differentiation is the actual materialization of that fate
Stims release of tyrosine - derived horms T3/T4 (increase basal metabolic rate); TSH increases thyroid cell size - number - rate of T3/T4 synth -----> thus - iodine deficiency causes swollen thyroid due to lack of neg feedback onto TSH in anterior pi
Duodenum (wraps around pancreas; most digestion occurs here) - jejunum (pH 7-9; 2m) - ileum
Glucose

19. in fat and liver cells monoglycerides and ffas are once again
Adrenocorticotropin; stims adrenal cortex release of glucocorticoids (eg cortisol - a steroid) stress hormones via second messenger system using cAMP
Micelles; micelles (made of bile) go back and forth between brush border and chyme
Reconstituted into TAGs at smooth ER; first stop for most digested fat is liver
Fat is insoluble in blood and requires a carrier like lipoproteins (vLDL...HDL) or albumins; ...vLDL has hi triglycerides - hi cholesterol

20. glucagon secreted by
Alpha cells; stims gluconeogenesis in liver; acts via cAMP second messenger
Within the paravertebral ganglion - running parallel to spinal cord
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics
Travels vas deferens - urethra; mixes with prostate fluids - seminal vesicles - couper's gland - etc

21. Path of urine

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22. Where do absorbed fats go in the enterocyte
Chyme (by combined activity of exocrine glands)
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum
Mediate complex cell processes thru eg phosphorylation via secondary messenger (G protein) systems = signal transduction pathway - GPCR (G protein coupled receptor)

23. Meiosis II: EQUATIONAL DIVISION
Micelles; micelles (made of bile) go back and forth between brush border and chyme
Prophase II: no crossing over b/c there are no homologous chromosomes; nuclear envelope dissolves Metaphase II: chromosomes line up at metaphase plate Anaphase II: sister chromatids separate - migrate to opp poles Telophase II: nuclear envelope reap
TAGS--->FFAs; remember that FFAs are broken down for energy in mito matrix by beta - oxidation
Sensory neurons are affector; motor neurons are effector // dorsal afferent (dorsal - Back- side of spinal cord carries sensory signals to brain; ventral effector

24. large intestine E. coli aid absorption of...
Vitamin K - b12 - thiamin - riboflavin
Epithelial tissue near semniferous tubules
Pancreas; active at sm intestinal pH; hydrolyzes peptide bonds of (pepsin - digested) peptides
Result is proton secreted into lumen - bicarbonate into interstitial fluid (diffuses into blood); result is also increased blood pH and decreased pH stomach

25. liver and blood glucose...
Sorts - modifies - concentrates proteins from the ER
Liver is the control center for blood glucose; is fed by portal vein from sm intest
Nitrogen
Raises BP; causes collecting ducts at end of nephron (kidney) to become permeable to water - which concentrates urine; coffee - beer block ADH and increase urine volume

26. Three stages of the menstrual cycle
The wall of the body or of a body cavity or hollow structure
Follicular (proliferative)= 8d - Luteal (post - ovulation; corpus luteum secretions)= 13d - Menstruation (shed uterine lining if no implantation)= 5
Lower blood pH
Processes: axons - dendrites

27. Meiosis I: REDUCTIONAL DIVISION Interphase: G1 (growth; enzymes - structural proteins needed for gametic production are synthesized); S (DNA of homologous chromosomes is duplicated; mother cell goes from 46 2N to 46 2N with sister chromosomes connect
Prophase I: crossing over occurs; nuclear envelope is absorbed into ER; chromosomes condense)
Two perpendicular semicircular canals involved in balance - equilibrium
Testes>Semeniferous tubules>Sertoli cells; feedback on AP FSH production
In mouth - breakdown of starch into polysaccharides

28. What is feces composed of...
Corpus luteum degrades into corpus albicans
It is the animal counterpart of starch; it is more highly- branched - thus releases more glucose monomers upon repeated hydrolysis than starch
Zygote (morula) composed of eight or more cells; All cells at this stage are TOTipOTENT STEM Cells: do not grow - form by cleavage
75% water/ 25% solid mass: of that solid mass: 10-20% fat = phospholipid bilayer of bacteria - slough - off enterocytes ie stomach lining (must be constantly rebuilt) 10-20% inorganic material 30% roughage = fiber = cellulose (indigestible) 2-3% prot

29. What is a dorsal root ganglion?
- parietal cells (**oxyntic= hi oxygen consumption - hi E??): have hi conc mito; need lots of energy to create proton gradient; thus - responsible for extremely harsh pH conditions in stom; denaturing conditions - chief cells (peptic): synthesize pep
Gastric inhibitory pep; increase of pancreatic - enz activating enzymes (which cleaves zymogens like trypsinogen); increased gall bladder contraction; decreases stomach mobility
Adrenal gland -- AC: steroids (cortisol - aldosterone); AM: catecholamines (epi - norepi); Islets of langerhans: peptides (insulin/glucagon) ANTAGONISTS: calcitonin (thyroid - peptide lowers Ca in blood); parathyroid hormone - peptide - vitamin D pat
Collection of cell bodies; cell processes project out from both ends of ganglion; synapses with interneuron in spinal cord on one end and sensory receptor on other

30. what else is located in the inner ear (not directly related to auditory)
Two perpendicular semicircular canals involved in balance - equilibrium
Oxidizes macromolecules; breaks down very long - chain FAs by beta - oxidation; products (acetyl - CoA) are shuttled to mitochondrion for citric acid cycle
Amino acid monomers - di - tri absorbed by symport at enterocyte; each AA has slightly diff mechanism; from entero - AAs enter bloodstream where they are taken up by all cells of the body - esp the liver by active or facilitated transport (NEVER PASS
'Increased absorptive area is useful because digested nutrients (including sugars and amino acids) pass into the villi through diffusion - which is effective only at short distances. In other words - **increased surface area (in contact with the flui

31. What testosterone released by secondary follicle by LH stim is converted to...
Growth 1 (G1) phase: STRUCTURAL ProteinS - ENZYMES; This is a very active period - where the cell synthesizes its vast array of proteins - including the enzymes and structural proteins it will need for growth. In G1 stage each of the chromosomes cons
***starting with adipose tiss: FFAs are transported in the blood by albumin (major component of blood plasma); one albumin typically carries three fatty acid molecules but can hold up to 30 FAs
Processes: axons - dendrites
Estradiol (estrogen - steroid horm); prepares uterine wall for pregnancy; just before ovulation - release of estradiol stims LH in pos feedback

32. Interaction of corpus luteum/placenta
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
Development of placenta begins with implantation; eventually - by end of first trimester - placenta will replace corpus luteum and its estrogen/progest secretions
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
Break down TAGs to monoglycerides and free fatty acids

33. What hormones affect the stomach?
Buildup of macromolecules in lysosome due to deficient lysosome enzymes
Hormones --->stimulate exocrine glands - acetylcholine (increases all secretion of gastric pits) - gastrin (from G cells) - histamine (increases HCl secretion of parietals) ...Ach increases all secretions; gastrin increases gastric acid (parietal cel
Primitive streak - which consists of cells of the MESODERM ****
Steroid; target tissue is distal convoluted tubule of nephron and collecting duct; increases blood mineral concentration; potassium - protons secreted (blood pH increases); sodium - chloride reabsorbed (BP increases)

34. Examples of GPCRs in sensory systems/signal transduction: What is the ligand or messenger in each case? ...SIGHT - SMELL - MOOD - FIGHT/FLIGHT etc
Salivary amylase (weak); sm intest amylase (breaks down large polysaccharides)
Sensory neurons are affector; motor neurons are effector // dorsal afferent (dorsal - Back- side of spinal cord carries sensory signals to brain; ventral effector
visual (rhodopsin is receptor - derived from Vit A; conformation change occurs with photon to hyperpolarize rod cells; cone cells use photopsin for receptor) - olfactory - mood (NTs targeted by antidepressants - antipsychotics - etc; GABA is inhibit
Organs

35. lysosome pH
Secreted by implanted egg; HCG prevents degeneration of the corpus luteum; HCG in blood/urine is first sign of pregnancy
5
Lots of energy; eg neurons have hi glucose need for 3Na out 2K in ATPase; stomach epithel tiss needs E for parietal cells to pump protons into lumen and bicarbonate into blood
Beta cells

36. in the presence of ADH what happens to movement of water across nephron membr
Travels vas deferens - urethra; mixes with prostate fluids - seminal vesicles - couper's gland - etc
Sensory (afferent - dorsal) - motor (efferent - ventral)
Water flows from the tubule - concentrating the filtrate - raising BP
Tight regulation of parietal cells needed b/c gastric acid secretion is E- intensive; parietal cells are hi in mitochons

37. What is an endorphin?
Glands w/ducts: Exocrine glands
An endogenous morphine
After morula - with blastocyst (+8 cell count)--->totipotent to embryonic stem cell and so on
Ventrally (picture skeletal vertebrae)

38. parathyroid hormones
At the first capillary bed of the nephron called the glomerulus which is encased by ***Bowman's capsule
Nitrogen
Peptides
Parathyroid hormone (peptide; increases blood Ca); thus - might increase osteoclast/decrease osteoblast activity

39. A group of cell bodies in CNS is nucleus - outside CNS is...
Ganglion
Presence of fat - prot in duodenum causes release of **gastric inhibitory peptide**; result is slower stomach contraction; slower emptying into duod thru pyloric sphincter (slower chyme secretion); more time to properly digest - absorb nutrients
Where lipoprotein lipase hydrolyzes TAGs; products diffuse into target tiss (mostly liver - adipose tissue)
Eg spinal nerve - cranial nerve; Not All Nervous Tissue In Brain - SC Is CNS Tissue

40. insulin secreted by
Beta cells
An ether phospholipid; hi conc in myelin; thus - hi conc in heart tiss - nervous tiss
23 N; 23 chromosomes and haploid (no homologous chromosomes); each chromosome has two sister chromatids Male: primary spermatocyte -->REDUCTIONAL DIVISION (first stim'd at puberty by GnRH - LH-->secondary spermatocyte Female: primary oocyte (arreste
***starting with adipose tiss: FFAs are transported in the blood by albumin (major component of blood plasma); one albumin typically carries three fatty acid molecules but can hold up to 30 FAs

41. What is secreted into filtrate by cells of the proximal tubule?
Secreted by implanted egg; HCG prevents degeneration of the corpus luteum; HCG in blood/urine is first sign of pregnancy
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics
Result is proton secreted into lumen - bicarbonate into interstitial fluid (diffuses into blood); result is also increased blood pH and decreased pH stomach
Comes into play in the large intestine - where vitamin b12 is absorbed w/help of E. coli; thus; must travel thru bloodstream to large intestine

42. Between meals most fats appear in blood as
Regulated by gastrointestinal horms
Lipoproteins; albumin carries free fatty acids when fat is mobilized from adipose tissue - etc
Alpha 1-4 and 1-6 (branching) glycosidic linkages
Renal pyramids --->renal calyx-->renal pelvis -->ureter -->urethra

43. Induction affects...
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
Direction of differentiation
Increases blood Calcium
pericardial cavity - pleural cavity (contains lungs) - peritoneal cavity (abdominal)

44. What is the path of a sound wave that enters the ear?
Somatic sensory = dorsal root ganglia (outside spinal cord); somatic effector = ventral horns of spinal cord
Bacterial flagellin: hollow filament (not microtub); euk: 9+2 microtubule w/dynein bridges
Outer ear= pinna (auricle)- external auditory canal - eardrum (tympanic membrane) inner ear= malleus - incus - stapes - ...oval window - cochlea - where sound is transduced into neural signal...enters cochlea at scala vestibuli - where pressure chang
SYMP: spinal cord --->paravetebral ganglion PARA: spinal cord - brain; cell processes --->ganglion near effector organ (preganglionic neurons) extend outside of spinal cord to synapse at ganglia - go on along postganglionic neurons

45. How long are peptides when absorbed at brush border
Two perpendicular semicircular canals involved in balance - equilibrium
'The hepatic portal vein is not a true vein - because it does not conduct blood directly to the heart. It is a vessel in the abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver.'
Small amounts of hydrolyzed phospholipids and cholesterol: like other fat mols these can diffuse thru enterocyte membrane
Di - tri - peptides; inside enterocytes are hydrolyzed to amino acids

46. Embryology
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes
Zygote - morula (first four days) - blastocyst (4 day+; implants in uterine lining) - gastrula (2 week) - neurula (3 week)...
Regulated by gastrointestinal horms
Formed in kidney (nephron) - sent thru renal pelvis - down ureter to bladder - drained by urethra'

47. Kidney physiology...

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48. bile + fat forms
'Microvilli function as the **primary surface of nutrient absorption in the gastrointestinal tract**. Because of this vital function - the microvillar membrane is packed with enzymes that aid in the breakdown of complex nutrients into simpler compoun
Changes: volume of filtrate does not change: osmolarity of filtrate --->reabsorbed ions like sodium carry water across membrane
Follicular (proliferative)= 8d - Luteal (post - ovulation; corpus luteum secretions)= 13d - Menstruation (shed uterine lining if no implantation)= 5
Micelles; micelles transport lipase products to enterocytes for absorption at brush border

49. A pinpoint iris is contracted or uncontracted
Sensory (afferent - dorsal) - motor (efferent - ventral)
Corpus luteum degrades into corpus albicans
Uncontracted: parasymp (eg opoid use)
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)

50. chylomicron concentration in blood after meal
Contains hydrolytic enzymes; thus - digests endocytosed substances; derived from golgi
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes
Carbohydrates are highly hydrated: one water mol per carbon mol - fats are anhydrous: contain more reduced carbons per unit mass - altogether fats contain 6X energy per unit mass
Prod of steroid hormones in testes - ovaries

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