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MCAT Prep - 2

Subjects : mcat, science

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Answer 50 questions in 15 minutes.
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1. In effect LH - FSH stimulate
Digestion
5
Chylomicrons are much bigger
Prod of steroid hormones in testes - ovaries

2. Interaction of corpus luteum/placenta
The renal corpuscle
Fat is insoluble in blood and requires a carrier like lipoproteins (vLDL...HDL) or albumins; ...vLDL has hi triglycerides - hi cholesterol
Meiosis creates germ cells
Development of placenta begins with implantation; eventually - by end of first trimester - placenta will replace corpus luteum and its estrogen/progest secretions

3. thyroid hormones: Not All One Kind of HORM
Stom= G cells (gastrin) - parietal (oxyntic); chief (peptic); mucous cells (hi ER - Golgi to make sticky glycoprots) - sm intest= enterocytes (w/brush border of maltase - sucrase - lactase - dextrinase; peptidase; lipase; nucleases); goblet cells (mu
Calcitonin (peptide; lowers blood Ca); T3/T4 (tyrosine - derived; increase basal metabolic rate); T4= thyroxine
Determined by whether in front of or behind the lens
ER

4. Where does the juxtaglomerular apparatus come into play...renin --->inc angiotensins -->inc aldosterone - ups BP
Monitors filtrate pressure in the distal tubule; has specialized cells (granular cells) that secrete an enzyme (**renin); renin initiates regulatory cascade that produces angiotensin I - II - III that stim adrenal cortex to secrete aldosterone... ...
Water flows from the tubule - concentrating the filtrate - raising BP
Chyme (by combined activity of exocrine glands)
Which is why lactase - maltase - dextrinase - sucrase are on brush border

5. 90% digestion - absorption occurs in...
PH 6.0; this accomplished by pancreatic secretion of bicarbonate which ups pH
'Microvilli function as the **primary surface of nutrient absorption in the gastrointestinal tract**. Because of this vital function - the microvillar membrane is packed with enzymes that aid in the breakdown of complex nutrients into simpler compoun
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
Prophase II: no crossing over b/c there are no homologous chromosomes; nuclear envelope dissolves Metaphase II: chromosomes line up at metaphase plate Anaphase II: sister chromatids separate - migrate to opp poles Telophase II: nuclear envelope reap

6. What are phagosomes
Synthesizes lipids (including steroids); detoxifies drugs; is continuous with lumen
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes
Membrane - bound - endocytosed bodies
Zygote - morula (first four days) - blastocyst (4 day+; implants in uterine lining) - gastrula (2 week) - neurula (3 week)...

7. How is the follicle developed during oogenesis
In liver (RBC recycling of heme); stored in gall bladder; released via cystic duct to common bile duct (shared w/liver); common bile duct joins up with panc duct...everything feeds into the sm intest at the ampulla of vater**
Contains hydrolytic enzymes; thus - digests endocytosed substances; derived from golgi
Arrested at primary oocyte; hypothalamus GnRH->FSH released at puberty stims granulosa cell development; granulosa secrete zona pellucida = primary follicle
Stom= G cells (gastrin) - parietal (oxyntic); chief (peptic); mucous cells (hi ER - Golgi to make sticky glycoprots) - sm intest= enterocytes (w/brush border of maltase - sucrase - lactase - dextrinase; peptidase; lipase; nucleases); goblet cells (mu

8. Examples of GPCRs in sensory systems/signal transduction: What is the ligand or messenger in each case? ...SIGHT - SMELL - MOOD - FIGHT/FLIGHT etc
- parietal cells (**oxyntic= hi oxygen consumption - hi E??): have hi conc mito; need lots of energy to create proton gradient; thus - responsible for extremely harsh pH conditions in stom; denaturing conditions - chief cells (peptic): synthesize pep
Estrogen: steroid; stims LH in luteal surge; causes growth of female sex organs progesterone: prepares/maintains uterus for pregnancy
Trypsin(- ogen; activates other panc enzymes after it is activated by enterokinase of sm intest); chymotrypsin - amylase - lipase
visual (rhodopsin is receptor - derived from Vit A; conformation change occurs with photon to hyperpolarize rod cells; cone cells use photopsin for receptor) - olfactory - mood (NTs targeted by antidepressants - antipsychotics - etc; GABA is inhibit

9. Meiosis I Anaphase I
Eg spinal nerve - cranial nerve; Not All Nervous Tissue In Brain - SC Is CNS Tissue
Homologous chromosomes separate - migrate towards opposite poles/centrioles
Uncontracted: parasymp (eg opoid use)
Stores blood: when expanded liver serves as blood reservoir for body - filters blood: Kupfer cells phagocytize bacteria picked up from intestines - destroys bad RBCs: also done by Kupfer cells - detoxifies blood: detoxified chemicals are excreted eit

10. at lo blood sugar...
Pancreas; active at sm intestinal pH; hydrolyzes peptide bonds of (pepsin - digested) peptides
ER
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)
Albumin increases osmolarity of blood; increases osmotic pressure

11. PNS is broken down into
AAs can be burned for energy or converted to fat for storage
Somatic nervous sys - autonomic nervous sys
Regulated by gastrointestinal horms
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr

12. During ejaculation - sperm...

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13. Where do absorbed fats go in the enterocyte
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
Liposome has phospholipid bilayer
Injury that does not sever SC (causes deep lesion from back - front) might cause loss of feeling without full loss of motion
'The hepatic portal vein is not a true vein - because it does not conduct blood directly to the heart. It is a vessel in the abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver.'

14. trypsin is secreted by
Presence of fat - prot in duodenum causes release of **gastric inhibitory peptide**; result is slower stomach contraction; slower emptying into duod thru pyloric sphincter (slower chyme secretion); more time to properly digest - absorb nutrients
Glycosaminoglycans - prots - AAs - lipids
Uncontracted: parasymp (eg opoid use)
Pancreas; active at sm intestinal pH; hydrolyzes peptide bonds of (pepsin - digested) peptides

15. Glucose is a .... sugar; fructose is a .... sugar
Glucose = aldose fructose = ketose
Travels vas deferens - urethra; mixes with prostate fluids - seminal vesicles - couper's gland - etc
Signal picked up by sensory cell - goes thru dorsal root ganglion to SC - may continue to interneurons in brain or simple reflex arc in SC - brain integrates info and decides (voluntary) response - travels back down SC to appropriate ventral root gan
Lumen (ie continuous w/body cavity) and cytosol

16. Embryology
Zygote (fertilization in fallopian tubes); morula (up to 8 cells - undifferentiated ie totipotent); blastocyst (4+ days - implants into uterus; HCG secretion stims corpus luteum; gradually placenta replaces HCG as estrogen/progest source; cells not t
Peptide; responsible for luteal surge (driven in part by LH-->testosterone -->estradiol -->LH positive feedback); results in ovulation (follicle bursting) - releasing egg into fallopian tube/oviduct
**only para effectors have muscarinic receptors; symp effectors are adrenergic (epi - norepi); **neuromuscular junction uses nicotinic receptors
**NO*** lipase digests fat; no bonds broken by bile; only opens up more SA for lipase

17. hypothalamus - AP - ACTH - cortisol release from adrenal cortex
Result: stress reaction; increase glycogenolysis - gluconeogenesis; fat/prot breakdown; increase blood glucose
Protein digestion begins in stomach; low pH denatures proteins - kills bacteria; mixes - stores food and destroys it to chyme (BOLUS-->CHYME)
Serous membrane (slick - reducing friction) that forms lining of the coelom --> secretes lubricating fluid
(diploid organism) humans are part of gametic life cycle ie produce gametes; diploid germ - line stem cells undergo meiosis to form haploid gametes

18. Posterior pituitary hormones (Small Peptides)
Sudiferous (sweat) - sebaceous - digestive (bile - pancreatic enzs) - mucosal
Bacterial flagellin: hollow filament (not microtub); euk: 9+2 microtubule w/dynein bridges
90-140 mg/dl
Oxytocin and ADH (aka vasopressin)

19. calcitonin

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20. sensory (afferent) neurons
Receive signals from receptor cell w/ ability to interact with its environment; 99% sensory input is discarded
Result is proton secreted into lumen - bicarbonate into interstitial fluid (diffuses into blood); result is also increased blood pH and decreased pH stomach
Conjunction of cell body w/axon
AAs enter bloodstream for uptake by all cells (esp liver). If intracellular prot conc is at max AAs can be converted to fats or glucose via gluconeogenesis. Byproduct of gluconeo is ammonia --->urea.

21. week three: neurulation; mesoderm induces ectoderm; thus - NEURULATION INVOLVES SC Development - at week three
It is the animal counterpart of starch; it is more highly- branched - thus releases more glucose monomers upon repeated hydrolysis than starch
Polysaccharides w/proteoglycans attached = glycosaminoglycans; often give pliability
Sensory neurons are affector; motor neurons are effector // dorsal afferent (dorsal - Back- side of spinal cord carries sensory signals to brain; ventral effector
Notochord (mesoderm) induces ectoderm to thicken into neural plate --->neural tube --->spinal cord

22. How does water cross the apical membrane
Lots of energy; eg neurons have hi glucose need for 3Na out 2K in ATPase; stomach epithel tiss needs E for parietal cells to pump protons into lumen and bicarbonate into blood
= catecholamines; fight/flight; vasoconstrictors of internal organs - skin; vasodilators of skel musc; also considered stress hormones; epinephrine - norepinephrine
Carbohydrates are highly hydrated: one water mol per carbon mol - fats are anhydrous: contain more reduced carbons per unit mass - altogether fats contain 6X energy per unit mass
Thru tight junctions by favorable osmotic gradient

23. What (typically - ie not pre - ovulation) feeds back to decrease LH - FSH production?
Testosterone and estradiol
Inner lining of blood vessels
Zygote (fertilization in fallopian tubes); morula (up to 8 cells - undifferentiated ie totipotent); blastocyst (4+ days - implants into uterus; HCG secretion stims corpus luteum; gradually placenta replaces HCG as estrogen/progest source; cells not t
Organs

24. serous membranes have a viscera - facing layer and a body wall - facing layer
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes
Break down TAGs to monoglycerides and free fatty acids
Adrenocorticotropin; stims adrenal cortex release of glucocorticoids (eg cortisol - a steroid) stress hormones via second messenger system using cAMP
Visceral layer= parietal layer; serous membrane is the container of the coelom/peritoneal cavity

25. In other words...
Four 23 N daughter cells are formed from one 46 2N mother (germ - line) cell; four haploid gametes
Water flows from the tubule - concentrating the filtrate - raising BP
Tight regulation of parietal cells needed b/c gastric acid secretion is E- intensive; parietal cells are hi in mitochons
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum

26. light detection via GPCRs
Peripheral nervous sys
Parathyroid hormone (peptide; increases blood Ca); thus - might increase osteoclast/decrease osteoblast activity
Peptide; prolactin promotes milk production; prolactin release is stimulated by act of suckling - which in turn inhibits menstrual cycle
Photon (hv)- rhodopsin - conformation change - GPCR- Na less permeable - hyperpolarized rod cells - generates AP= photobleaching at visible light wavelengths (390-700nm)

27. these transport proteins - when concs are high enough...
cornea (1.4 refractory index; bends light) - pupil (size of pupil is determined by contraction state of the iris) - aqueous humor
Fat synthesis; carbs stored as free fatty acids - esterified to TAGs (requires small amount of E)
Only musc and esp ** liver can store large amounts
Can be saturated; conc of a solute is called the transport maximum --->excess goes into urine

28. After meiosis II - Female

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29. fructose enters enterocyte by
Pancreatic duct (made of acinar cells?)
Carbohydrates are highly hydrated: one water mol per carbon mol - fats are anhydrous: contain more reduced carbons per unit mass - altogether fats contain 6X energy per unit mass
Facilitated diffusion: no symport w/ secondary transport
Inner lining of blood vessels

30. What are the memb - bound enzymes of the brush border?
Di - tri - peptides; inside enterocytes are hydrolyzed to amino acids
**only para effectors have muscarinic receptors; symp effectors are adrenergic (epi - norepi); **neuromuscular junction uses nicotinic receptors
Lowers osmolarity of the filtrate (IONS - Water Are Taken Back Up By The Kidney)--->at the end of the distal tubule (the collecting tubule) is where aldosterone acts - along with the JGA
CARB- Digesting: dextrinase (polysachs produced by hydrolysis of starch) - maltase (glucose - glucose) - sucrase (glucose - fructose) - lactase (galactose - glucose) - Protein- Digesting: peptidases - NUCLEOTIDE- Digesting: nucleosidases

31. How does blood sugar move into tissues?
Facilitated diffusion from hi to lo conc
Sensory neurons are affector; motor neurons are effector // dorsal afferent (dorsal - Back- side of spinal cord carries sensory signals to brain; ventral effector
'The hepatic portal vein is not a true vein - because it does not conduct blood directly to the heart. It is a vessel in the abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver.'
Homologous chromosomes separate - migrate towards opposite poles/centrioles

32. Important aspect of crypt of Lieberkuhn - secreted intestinal juice
Lots of energy; eg neurons have hi glucose need for 3Na out 2K in ATPase; stomach epithel tiss needs E for parietal cells to pump protons into lumen and bicarbonate into blood
Going up - water - impermeable: salt is actively pumped out - filtrate osmolarity goes down as salt leaves
Contains lysozyme - which regulates bacteria within intestine; breaks down peptidoglycans (**bact wall); innate immunity
Secondary spermatocyte (stim'd by FSH from Sertoli cells -->EQUATIONAL DIVISION-->spermatid - which matures further into spermatozoa; released into semeniferous tubule; transported to epididymis

33. What is the endothelium?
Parathyroid hormone (peptide; increases blood Ca); thus - might increase osteoclast/decrease osteoblast activity
Inner lining of circulatory system
Micelles; micelles (made of bile) go back and forth between brush border and chyme
Membrane - bound - endocytosed bodies

34. How does birth control work?
Maintains hi estrogen levels; body does not recognize luteal surge - ovulation does not occur; hi progesterone can lessen shedding by thickening the uterine lining
Systems (eg digestive system consists of many organs)
- enterocytes w/ *microvilli brush border*: membrane - bound digestive enzymes for carbs - fats - nucleic acids - goblet cells: secrete mucous - Deep between villi are the intestinal exocrine glands - the crypts of Lieberkuhn - which secrete pH 7.6 i
Hormones --->stimulate exocrine glands - acetylcholine (increases all secretion of gastric pits) - gastrin (from G cells) - histamine (increases HCl secretion of parietals) ...Ach increases all secretions; gastrin increases gastric acid (parietal cel

35. medium for paracrine hormones
Glands w/ducts: Exocrine glands
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr
Interstitial fluid (eg prostaglandins - cytokines)
Alpha cells; stims gluconeogenesis in liver; acts via cAMP second messenger

36. PNS review: SAME DAVE
Testosterone upon stim by LH
Sensory neurons are affector; motor neurons are effector // dorsal afferent (dorsal - Back- side of spinal cord carries sensory signals to brain; ventral effector
via symport - secondary transport (ie by pre - established - ATP- intensive) with Na gradient into enterocyte......with no Na gradient (ie without ATP) carbohydrate monomers could not be transported in
Fructose is a structural isomer of glucose

37. Thus - central nervous sys is...
Carry signals to musc OR Gland
Determined by whether in front of or behind the lens
Interneurons working to integrate signals received from the peripheral nervous system (sense organs)
Renal pyramids --->renal calyx-->renal pelvis -->ureter -->urethra

38. only monosaccharides are absorbed
sucrose (gluc+fruc) - lactose (gluc+galactose) - starch (gluc+gluc)
Which is why lactase - maltase - dextrinase - sucrase are on brush border
Visceral layer= parietal layer; serous membrane is the container of the coelom/peritoneal cavity
Outermost layer of blood vessel

39. Ovum development is halted At what stage until fertilization...
Salivary amylase; both hydrolyze glycosidic linkages
At metaphase II of meiosis II (halted during reductional division); if fertilized - process continues toward haploid gamete
Chyme (by combined activity of exocrine glands)
Maintains hi estrogen levels; body does not recognize luteal surge - ovulation does not occur; hi progesterone can lessen shedding by thickening the uterine lining

40. What is secreted into filtrate by cells of the proximal tubule?
Presence of fat - prot in duodenum causes release of **gastric inhibitory peptide**; result is slower stomach contraction; slower emptying into duod thru pyloric sphincter (slower chyme secretion); more time to properly digest - absorb nutrients
Calcitonin (peptide; lowers blood Ca); T3/T4 (tyrosine - derived; increase basal metabolic rate); T4= thyroxine
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics
Raises BP; causes collecting ducts at end of nephron (kidney) to become permeable to water - which concentrates urine; coffee - beer block ADH and increase urine volume

41. How does reabsorption force nutrients across apical membrane of proximal tubule
AAs can be burned for energy or converted to fat for storage
Alpha 1-4 and 1-6 (branching) glycosidic linkages
Via secondary active transport proteins (COSTS E TO FILTER BLOOD - ESTABLISH FLUID/ION BALANCE)
Peptide; responsible for luteal surge (driven in part by LH-->testosterone -->estradiol -->LH positive feedback); results in ovulation (follicle bursting) - releasing egg into fallopian tube/oviduct

42. lysosome pH
5
Night vision
- enterocytes w/ *microvilli brush border*: membrane - bound digestive enzymes for carbs - fats - nucleic acids - goblet cells: secrete mucous - Deep between villi are the intestinal exocrine glands - the crypts of Lieberkuhn - which secrete pH 7.6 i
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum

43. cholinergic receptors: NICTONIC and MUSCARINIC Nicotinic: neuromuscular effectors (ionotropic) Muscarinic: PARA effectors (GPCRs) Adrenergic: SYMP effectors (GPCRs)
Steroid; target tissue is distal convoluted tubule of nephron and collecting duct; increases blood mineral concentration; potassium - protons secreted (blood pH increases); sodium - chloride reabsorbed (BP increases)
**only para effectors have muscarinic receptors; symp effectors are adrenergic (epi - norepi); **neuromuscular junction uses nicotinic receptors
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
The crypts of Lieberkuhn: sm intestine pH is not right; brush border enzs won't work right

44. testosterone can be aromatized to...
Stom= G cells (gastrin) - parietal (oxyntic); chief (peptic); mucous cells (hi ER - Golgi to make sticky glycoprots) - sm intest= enterocytes (w/brush border of maltase - sucrase - lactase - dextrinase; peptidase; lipase; nucleases); goblet cells (mu
Estradiol
Lysosome
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum

45. Tight junctions
Estrogen: steroid; stims LH in luteal surge; causes growth of female sex organs progesterone: prepares/maintains uterus for pregnancy
Calcitonin (peptide; lowers blood Ca); T3/T4 (tyrosine - derived; increase basal metabolic rate); T4= thyroxine
Form barrier to extracellular fluid
Work together to emulsify fats: bile works as a detergent to increase SA of the fat; increased SA gives more substrate to lipase for digestion

46. Which fats are not absorbed like this
Secondary spermatocyte (stim'd by FSH from Sertoli cells -->EQUATIONAL DIVISION-->spermatid - which matures further into spermatozoa; released into semeniferous tubule; transported to epididymis
Smaller - more water soluble short - chain FAs go directly to bloodstream at villi capillaries
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes
At metaphase II of meiosis II (halted during reductional division); if fertilized - process continues toward haploid gamete

47. hypothalamus controls anterior pit - posterior pit release with inhibitory/releasing hormones of its own; these should have fairly self - explanatory names
'Increased absorptive area is useful because digested nutrients (including sugars and amino acids) pass into the villi through diffusion - which is effective only at short distances. In other words - **increased surface area (in contact with the flui
Hypothalamus --->AP--->target tissues eg TSH - thyroid - T3/T4 release - increase basal metabolic rate
(diploid organism) humans are part of gametic life cycle ie produce gametes; diploid germ - line stem cells undergo meiosis to form haploid gametes
Nervous - muscle - epithelial (defines inner/outer) - connective (extensive matrices)

48. Meiosis I Metaphase I
Normally contracted
Homologous chromosomes line up w/ attachment of spindle fibers/microtubule polymers to centromeres via kinetochores; identical in appearance under light microscope to metaphase of mitosis
Secondary follicle: Theca cells differentiate from interstitial tissue - surround follicle - secrete testosterone when stimd by LH (compare to Leydig cells)
Pancreas; active at sm intestinal pH; hydrolyzes peptide bonds of (pepsin - digested) peptides

49. From that point...
An endogenous morphine
Ventrally (picture skeletal vertebrae)
Nervous - muscle - epithelial (defines inner/outer) - connective (extensive matrices)
AAs enter bloodstream for uptake by all cells (esp liver). If intracellular prot conc is at max AAs can be converted to fats or glucose via gluconeogenesis. Byproduct of gluconeo is ammonia --->urea.

50. Aldosterone (sodium uptake - potassium secretion)
Lens will be rounded; contraction of the lens (ie focusing) is done by ciliary muscle
Steroid; target tissue is distal convoluted tubule of nephron and collecting duct; increases blood mineral concentration; potassium - protons secreted (blood pH increases); sodium - chloride reabsorbed (BP increases)
The crypts of Lieberkuhn: sm intestine pH is not right; brush border enzs won't work right
Digestion

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