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MCAT Prep - 2

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1. what else is located in the inner ear (not directly related to auditory)
Zygote (morula) composed of eight or more cells; All cells at this stage are TOTipOTENT STEM Cells: do not grow - form by cleavage
Two perpendicular semicircular canals involved in balance - equilibrium
From lumenal (apical) to enterocyte to basolateral side of epithelial tissue
'visceral organs develop adjacent to a cavity and invaginate into the bag - like coelom'

2. Examples of GPCRs in sensory systems/signal transduction: What is the ligand or messenger in each case? ...SIGHT - SMELL - MOOD - FIGHT/FLIGHT etc
visual (rhodopsin is receptor - derived from Vit A; conformation change occurs with photon to hyperpolarize rod cells; cone cells use photopsin for receptor) - olfactory - mood (NTs targeted by antidepressants - antipsychotics - etc; GABA is inhibit
Apoproteins attach to outside of globules; these move to Golgi and are released into interstitial fluid via exocytosis as chylomicrons --->most go to lacteal system
Size of fist; two kidneys; have cortex (steroid hormones) and medulla (catecholamines) - receives about 20% of cardiac output - blood travels down arteries - up veins -'urine is created by the kidney and emptied into the renal pelvis - which is empti
(haploid organism) many fungi and protozoa; individuals are typically haploid; fertilization may occur with immediate meiosis back to haploid state

3. Where is bile produced
Going up - water - impermeable: salt is actively pumped out - filtrate osmolarity goes down as salt leaves
Inactive: rhodopsin is activated by photons; activated rhodopsin hyperpolarizes rod cells - causes photobleaching
In liver (RBC recycling of heme); stored in gall bladder; released via cystic duct to common bile duct (shared w/liver); common bile duct joins up with panc duct...everything feeds into the sm intest at the ampulla of vater**
In gastric pits; secretions combine into gastric juice

4. from the loop of henle...
On to the distal tubule where sodium - calcium are reabsorbed - protons - bicarbonate - potassium are secreted via membrane transport proteins
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)
Oxytocin and ADH (aka vasopressin)
Primitive streak - which consists of cells of the MESODERM ****

5. What are the major carbohydrates
Maintains hi estrogen levels; body does not recognize luteal surge - ovulation does not occur; hi progesterone can lessen shedding by thickening the uterine lining
- enterocytes w/ *microvilli brush border*: membrane - bound digestive enzymes for carbs - fats - nucleic acids - goblet cells: secrete mucous - Deep between villi are the intestinal exocrine glands - the crypts of Lieberkuhn - which secrete pH 7.6 i
Micelles; micelles transport lipase products to enterocytes for absorption at brush border
sucrose (gluc+fruc) - lactose (gluc+galactose) - starch (gluc+gluc)

6. How does birth control work?
Increases surface area of food ball (bolus)
Maintains hi estrogen levels; body does not recognize luteal surge - ovulation does not occur; hi progesterone can lessen shedding by thickening the uterine lining
Ammonia; must be converted to urea by liver and excreted in urine by kidney
cornea (1.4 refractory index; bends light) - pupil (size of pupil is determined by contraction state of the iris) - aqueous humor

7. overall - fatty - prot - rich food in duod causes
Going up - water - impermeable: salt is actively pumped out - filtrate osmolarity goes down as salt leaves
Gastric inhibitory pep; increase of pancreatic - enz activating enzymes (which cleaves zymogens like trypsinogen); increased gall bladder contraction; decreases stomach mobility
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr
Injury that does not sever SC (causes deep lesion from back - front) might cause loss of feeling without full loss of motion

8. What does peroxisome do
Bacterial flagellin: hollow filament (not microtub); euk: 9+2 microtubule w/dynein bridges
Zygote - morula (first four days) - blastocyst (4 day+; implants in uterine lining) - gastrula (2 week) - neurula (3 week)...
(diploid organism) humans are part of gametic life cycle ie produce gametes; diploid germ - line stem cells undergo meiosis to form haploid gametes
Oxidizes macromolecules; breaks down very long - chain FAs by beta - oxidation; products (acetyl - CoA) are shuttled to mitochondrion for citric acid cycle

9. chylomicron concentration in blood after meal
Increases blood Calcium
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes
Calcitonin (peptide; lowers blood Ca); T3/T4 (tyrosine - derived; increase basal metabolic rate); T4= thyroxine
Via secondary active transport proteins (COSTS E TO FILTER BLOOD - ESTABLISH FLUID/ION BALANCE)

10. ligands are the messenger compounds that target secondary messenger systems on effectors
Steroid; target tissue is distal convoluted tubule of nephron and collecting duct; increases blood mineral concentration; potassium - protons secreted (blood pH increases); sodium - chloride reabsorbed (BP increases)
Many modern drugs are ligands for GPCRs
Cancer; apop can be programmed cell death; mitochon can play important role in apop
Salivary amylase; both hydrolyze glycosidic linkages

11. Adrenal cortex hormones (STEROIDS)
Sympathetic: dilates pupil (for night hunting)
Ammonia; must be converted to urea by liver and excreted in urine by kidney
Glucocorticoid (cortisol); mineralocorticoid (aldosterone)
Serous membrane (slick - reducing friction) that forms lining of the coelom --> secretes lubricating fluid

12. Meiosis I Telophase I
Organs
Ketone bodies; thus excessive reliance on fat for energy (eg low carb diets) results in ketosis; blood acidity increases
'visceral organs develop adjacent to a cavity and invaginate into the bag - like coelom'
Nuclear envelope reassembled in daughter cells; cytokinesis occurs; nucleoli reappear (site of rRNA synthesis)

13. Polypeptides are formed with what kind of reaction?
Dehydration reaction; broken apart with enzyme - catalyzed hydrolysis
5
Hypothalamus --->AP--->target tissues eg TSH - thyroid - T3/T4 release - increase basal metabolic rate
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr

14. week three: neurulation; mesoderm induces ectoderm; thus - NEURULATION INVOLVES SC Development - at week three
Interstitial fluid (eg prostaglandins - cytokines)
Notochord (mesoderm) induces ectoderm to thicken into neural plate --->neural tube --->spinal cord
Nervous - muscle - epithelial (defines inner/outer) - connective (extensive matrices)
Hydrostatic pressure forces some plasma thru *fenestrations of the glomerular endothelium* and into Bowman's capsule; B.C. is continuous with lumen of nephron

15. zygotic life cycle
(haploid organism) many fungi and protozoa; individuals are typically haploid; fertilization may occur with immediate meiosis back to haploid state
On to the distal tubule where sodium - calcium are reabsorbed - protons - bicarbonate - potassium are secreted via membrane transport proteins
Fat is insoluble in blood and requires a carrier like lipoproteins (vLDL...HDL) or albumins; ...vLDL has hi triglycerides - hi cholesterol
Gall bladder - pancreatic secretions increase - arrive via ampulla of vater (duct glands); insulin secretion increases (fed state; ductless glands)

16. main point of fat transport...
Neurons may perform one of three functions....
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
Within the paravertebral ganglion - running parallel to spinal cord
Fat is insoluble in blood and requires a carrier like lipoproteins (vLDL...HDL) or albumins; ...vLDL has hi triglycerides - hi cholesterol

17. What is main difference is signal transmission in nicotinic vs muscarinic?
Night vision
Glands w/ducts: Exocrine glands
Liver Functions pt. 2 - Carb metabolism: blood is sent straight to liver from sm intest thru portal vein; liver is control center for blood glucose; _______________ - fat metabolism: oxidizes fat for energy by beta - oxidation - forms most lipoprotei
***nicotinic is ionotropic; muscarinic is GPCR

18. What is secreted into filtrate by cells of the proximal tubule?
Conjunction of cell body w/axon
Prophase II: no crossing over b/c there are no homologous chromosomes; nuclear envelope dissolves Metaphase II: chromosomes line up at metaphase plate Anaphase II: sister chromatids separate - migrate to opp poles Telophase II: nuclear envelope reap
Increases surface area of food ball (bolus)
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics

19. What is a dorsal root ganglion?
Which is why lactase - maltase - dextrinase - sucrase are on brush border
Testosterone upon stim by LH
Oxytocin and ADH (aka vasopressin)
Collection of cell bodies; cell processes project out from both ends of ganglion; synapses with interneuron in spinal cord on one end and sensory receptor on other

20. axon hillock physiology
Dehydration reaction; broken apart with enzyme - catalyzed hydrolysis
Result: stress reaction; increase glycogenolysis - gluconeogenesis; fat/prot breakdown; increase blood glucose
REABSORPTION: draws off water and ions - increases osmolarity of the medulla while slightly lowering osmolarity of the filtrate -->medulla must have hi osmolarity in order to concentrate urine at collecting duct (final step in nephron)
Conjunction of cell body w/axon

21. AP- peptides (FSH - LH - ACTH - TSH - prolactin - hGH); PP- peptides (ADH - oxytocin); thyroid - peptide *and* tyr - derived (T3/T4 - calcitonin); parathyroid - peptide (PTH; raise blood Ca via pathway involving vitamin D)
REABSORPTION: draws off water and ions - increases osmolarity of the medulla while slightly lowering osmolarity of the filtrate -->medulla must have hi osmolarity in order to concentrate urine at collecting duct (final step in nephron)
Fovea (highest amount of cones)
Adrenal gland -- AC: steroids (cortisol - aldosterone); AM: catecholamines (epi - norepi); Islets of langerhans: peptides (insulin/glucagon) ANTAGONISTS: calcitonin (thyroid - peptide lowers Ca in blood); parathyroid hormone - peptide - vitamin D pat
AAs can be burned for energy or converted to fat for storage

22. After meiosis II...
Four 23 N daughter cells are formed from one 46 2N mother (germ - line) cell; four haploid gametes
Albumin increases osmolarity of blood; increases osmotic pressure
About 7.2
Posterior pituitary hormone; acts on uterus - mammary glands; causes uterine contractions - milk ejection

23. Important aspect of crypt of Lieberkuhn - secreted intestinal juice
Contains lysozyme - which regulates bacteria within intestine; breaks down peptidoglycans (**bact wall); innate immunity
About 7.2
Alpha cells; stims gluconeogenesis in liver; acts via cAMP second messenger
Hydrostatic pressure forces some plasma thru *fenestrations of the glomerular endothelium* and into Bowman's capsule; B.C. is continuous with lumen of nephron

24. cAMP - cGMP - calmodulin...
Mediate complex cell processes thru eg phosphorylation via secondary messenger (G protein) systems = signal transduction pathway - GPCR (G protein coupled receptor)
On the chyme exiting the stomach and entering duodenum thru the pyloric sphincter
Notochord (mesoderm) induces ectoderm to thicken into neural plate --->neural tube --->spinal cord
Secreted by implanted egg; HCG prevents degeneration of the corpus luteum; HCG in blood/urine is first sign of pregnancy

25. Inside the kidney: ...JGA (w/granular cells sensitive to hydrostatic pressure able to secrete renin - activate aldosterone - increase BP) is adjacent to distal tubule - monitors filtrate pressure
- filtration occurs at the fenestrations of the renal corpuscle - most reabsorption and secretion occur in the proximal tubule - medulla is concentrated in the loop of henle - sodium and calcium are reabsorbed in the distal tubule -->collecting tubul
Nitrogen
(haploid organism) many fungi and protozoa; individuals are typically haploid; fertilization may occur with immediate meiosis back to haploid state
Conjunction of cell body w/axon

26. Path of food entering body...
In mouth - breakdown of starch into polysaccharides
Mouth - esophagus - stomach - duodenum - jejunum - ileum - ascending colon - transverse colon - descending colon - sigmoid colon - rectum - anus
From lumenal (apical) to enterocyte to basolateral side of epithelial tissue
Dehydration reaction; broken apart with enzyme - catalyzed hydrolysis

27. How does reabsorption force nutrients across apical membrane of proximal tubule
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)
Via secondary active transport proteins (COSTS E TO FILTER BLOOD - ESTABLISH FLUID/ION BALANCE)
Organs
Secondary spermatocyte (stim'd by FSH from Sertoli cells -->EQUATIONAL DIVISION-->spermatid - which matures further into spermatozoa; released into semeniferous tubule; transported to epididymis

28. in fat and liver cells monoglycerides and ffas are once again
Sudiferous (sweat) - sebaceous - digestive (bile - pancreatic enzs) - mucosal
Reconstituted into TAGs at smooth ER; first stop for most digested fat is liver
Urine enters kidneys via artery - to arteriole - capillary bed - glomerulus - Bowman's capsule - proximal tubule - loop of henle (concentrates medulla) - distal tubule - collecting tubule - collecting duct (renal pyramids) - renal calyx - renal pelvi
Secondary follicle: Theca cells differentiate from interstitial tissue - surround follicle - secrete testosterone when stimd by LH (compare to Leydig cells)

29. lining of abdominal cavity=
Serous membrane (slick - reducing friction) that forms lining of the coelom --> secretes lubricating fluid
Dehydration reaction; broken apart with enzyme - catalyzed hydrolysis
Zygote (morula) composed of eight or more cells; All cells at this stage are TOTipOTENT STEM Cells: do not grow - form by cleavage
Amino acid monomers - di - tri absorbed by symport at enterocyte; each AA has slightly diff mechanism; from entero - AAs enter bloodstream where they are taken up by all cells of the body - esp the liver by active or facilitated transport (NEVER PASS

30. Where do absorbed fats go in the enterocyte
***nicotinic is ionotropic; muscarinic is GPCR
Follicular (proliferative)= 8d - Luteal (post - ovulation; corpus luteum secretions)= 13d - Menstruation (shed uterine lining if no implantation)= 5
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
Chylomicrons are much bigger

31. serous membranes have a viscera - facing layer and a body wall - facing layer
Hormones --->stimulate exocrine glands - acetylcholine (increases all secretion of gastric pits) - gastrin (from G cells) - histamine (increases HCl secretion of parietals) ...Ach increases all secretions; gastrin increases gastric acid (parietal cel
Di - tri - peptides; inside enterocytes are hydrolyzed to amino acids
Number of centromeres - Not number of chromatids eg - two sister chromatids connected by one centromere = one chromosome
Visceral layer= parietal layer; serous membrane is the container of the coelom/peritoneal cavity

32. So - following blastocyst implantation (4d) - at approx 2 weeks past fertilization
Nuclear envelope reassembled in daughter cells; cytokinesis occurs; nucleoli reappear (site of rRNA synthesis)
Gastrulation occurs: formation of three primary germ layers = differentiation
= catecholamines; fight/flight; vasoconstrictors of internal organs - skin; vasodilators of skel musc; also considered stress hormones; epinephrine - norepinephrine
Raises BP; causes collecting ducts at end of nephron (kidney) to become permeable to water - which concentrates urine; coffee - beer block ADH and increase urine volume

33. keep in mind that enterocyte is like a regular euk cell
Has memb - bound organelles - etc...
Changes: volume of filtrate does not change: osmolarity of filtrate --->reabsorbed ions like sodium carry water across membrane
Growth 1 (G1) phase: STRUCTURAL ProteinS - ENZYMES; This is a very active period - where the cell synthesizes its vast array of proteins - including the enzymes and structural proteins it will need for growth. In G1 stage each of the chromosomes cons
In liver (RBC recycling of heme); stored in gall bladder; released via cystic duct to common bile duct (shared w/liver); common bile duct joins up with panc duct...everything feeds into the sm intest at the ampulla of vater**

34. remaining secondary follicle becomes
Know that 90% digestion - absorption occurs in sm intestine --> fine breakdown of carbs - fat - prots
RBCs - large proteins; What does enter is called the filtrate
All carbs absorbed at enterocytes are carried to liver by portal vein
Corpus luteum; secretes estradiol - progesterone throughout pregnancy OR if no pregnancy - for about 2 weeks (till menstruation = shedding of uterine lining)

35. fat digestion is time - intensive
Membrane - bound - endocytosed bodies
Paracrine (local) - endocrine (longer distance)
Organs
Needs time for bile - lipase - micelle migration - enterocyte uptake

36. at lo blood sugar...
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)
Direction of differentiation
Synthesizes lipids (including steroids); detoxifies drugs; is continuous with lumen
At metaphase II of meiosis II (halted during reductional division); if fertilized - process continues toward haploid gamete

37. what cannot cross the fenestrations of the renal corpuscle
RBCs - large proteins; What does enter is called the filtrate
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum
Travels vas deferens - urethra; mixes with prostate fluids - seminal vesicles - couper's gland - etc
Peptide; prolactin promotes milk production; prolactin release is stimulated by act of suckling - which in turn inhibits menstrual cycle

38. How long are peptides when absorbed at brush border
Di - tri - peptides; inside enterocytes are hydrolyzed to amino acids
Homologous chromosomes line up w/ attachment of spindle fibers/microtubule polymers to centromeres via kinetochores; identical in appearance under light microscope to metaphase of mitosis
Facilitated diffusion from hi to lo conc
Presence of fat - prot in duodenum causes release of **gastric inhibitory peptide**; result is slower stomach contraction; slower emptying into duod thru pyloric sphincter (slower chyme secretion); more time to properly digest - absorb nutrients

39. How does blood sugar move into tissues?
Sudiferous (sweat) - sebaceous - digestive (bile - pancreatic enzs) - mucosal
Calcitonin (peptide; lowers blood Ca); T3/T4 (tyrosine - derived; increase basal metabolic rate); T4= thyroxine
Facilitated diffusion from hi to lo conc
Somatic sensory = dorsal root ganglia (outside spinal cord); somatic effector = ventral horns of spinal cord

40. What is a nerve? (PNS)
Vitamin K - b12 - thiamin - riboflavin
Called a tract in the CNS; bundling together of axons/dendrites thru which many diff signals pass; many many neurons are bundled together into a single nerve
Fat synthesis; carbs stored as free fatty acids - esterified to TAGs (requires small amount of E)
Meiosis creates germ cells

41. Local vs long - distance mediators
***starting with adipose tiss: FFAs are transported in the blood by albumin (major component of blood plasma); one albumin typically carries three fatty acid molecules but can hold up to 30 FAs
Mediate complex cell processes thru eg phosphorylation via secondary messenger (G protein) systems = signal transduction pathway - GPCR (G protein coupled receptor)
Paracrine (local) - endocrine (longer distance)
Many modern drugs are ligands for GPCRs

42. Interaction of corpus luteum/placenta
Digestion
Development of placenta begins with implantation; eventually - by end of first trimester - placenta will replace corpus luteum and its estrogen/progest secretions
Primitive streak - which consists of cells of the MESODERM ****
Secreted by delta cells of Islets of langerhans; inhibits insulin and glucagon; slows digestion

43. mucus cells line the stomach...
Stores blood: when expanded liver serves as blood reservoir for body - filters blood: Kupfer cells phagocytize bacteria picked up from intestines - destroys bad RBCs: also done by Kupfer cells - detoxifies blood: detoxified chemicals are excreted eit
Contain rough ER and Golgi to make mucous; mucous is full of **glycoprots (sticky) and electrolytes*; protects epithelial tiss of stomach from low pH and lubricates stomach
Posterior pituitary hormone; acts on uterus - mammary glands; causes uterine contractions - milk ejection
On to the distal tubule where sodium - calcium are reabsorbed - protons - bicarbonate - potassium are secreted via membrane transport proteins

44. What force is acting upon chyme to move it forward down sm intestine
Peristalsis (esophagus) and segmentation (bi - directional=mixing)
Secondary follicle: Theca cells differentiate from interstitial tissue - surround follicle - secrete testosterone when stimd by LH (compare to Leydig cells)
Comes into play in the large intestine - where vitamin b12 is absorbed w/help of E. coli; thus; must travel thru bloodstream to large intestine
Corpus luteum; secretes estradiol - progesterone throughout pregnancy OR if no pregnancy - for about 2 weeks (till menstruation = shedding of uterine lining)

45. medium for paracrine hormones
Interstitial fluid (eg prostaglandins - cytokines)
Notochord (mesoderm) induces ectoderm to thicken into neural plate --->neural tube --->spinal cord
Moves down thru esophageal sphincter
Increases surface area of food ball (bolus)

46. Where does the bolus go after mouth chews food
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
Moves down thru esophageal sphincter
About 7.2
Parathyroid hormone (peptide; increases blood Ca); thus - might increase osteoclast/decrease osteoblast activity

47. Thus inhibiting parietal cells could do What to blood pH
Prod of steroid hormones in testes - ovaries
Injury that does not sever SC (causes deep lesion from back - front) might cause loss of feeling without full loss of motion
Eg spinal nerve - cranial nerve; Not All Nervous Tissue In Brain - SC Is CNS Tissue
Lower blood pH

48. Does bile digest fat?
**NO*** lipase digests fat; no bonds broken by bile; only opens up more SA for lipase
Fallopian tubes
Glands w/ducts: Exocrine glands
Increase surface area of sm intestine; this improves digestion (enzymes adsorbed to villi) and absorption

49. gametic life cycle
Membrane - bound - endocytosed bodies
(diploid organism) humans are part of gametic life cycle ie produce gametes; diploid germ - line stem cells undergo meiosis to form haploid gametes
(diploid and haploid individuals = ALTERNATION of GENERATIONS) a fusion of gametic and zygotic life cycles
Duodenum (wraps around pancreas; most digestion occurs here) - jejunum (pH 7-9; 2m) - ileum

50. What does portal vein do
Interstitial fluid (eg prostaglandins - cytokines)
All carbs absorbed at enterocytes are carried to liver by portal vein
Size of fist; two kidneys; have cortex (steroid hormones) and medulla (catecholamines) - receives about 20% of cardiac output - blood travels down arteries - up veins -'urine is created by the kidney and emptied into the renal pelvis - which is empti
Smaller - more water soluble short - chain FAs go directly to bloodstream at villi capillaries

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