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MCAT Prep - 2

Subjects : mcat, science

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What is somatostatin
Secreted by delta cells of Islets of langerhans; inhibits insulin and glucagon; slows digestion
Thru tight junctions by favorable osmotic gradient
It is the animal counterpart of starch; it is more highly- branched - thus releases more glucose monomers upon repeated hydrolysis than starch
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)

2. food in duod stims release of gastrointestinal hormones
'tones the bone'; decreases free Calcium conc; acts opposite to parathyroid hormone; thyroid polypeptide
Fat is insoluble in blood and requires a carrier like lipoproteins (vLDL...HDL) or albumins; ...vLDL has hi triglycerides - hi cholesterol
Tight regulation of parietal cells needed b/c gastric acid secretion is E- intensive; parietal cells are hi in mitochons
Gall bladder - pancreatic secretions increase - arrive via ampulla of vater (duct glands); insulin secretion increases (fed state; ductless glands)

3. going down the loop of Henle - water - permeable - filtrate osmolarity goes up as water leaves...
Going up - water - impermeable: salt is actively pumped out - filtrate osmolarity goes down as salt leaves
Stomach - sm intest - spleen - pancreas from the hepatic portal vein...all blood that passes thru liver go thru flattened spaces called the ***hepatic sinusoids -->hepatic vein --->vena cava
Testosterone upon stim by LH
On to the distal tubule where sodium - calcium are reabsorbed - protons - bicarbonate - potassium are secreted via membrane transport proteins

4. Where do absorbed fats go in the enterocyte
Monitors filtrate pressure in the distal tubule; has specialized cells (granular cells) that secrete an enzyme (**renin); renin initiates regulatory cascade that produces angiotensin I - II - III that stim adrenal cortex to secrete aldosterone... ...
90-140 mg/dl
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
Micelles; micelles (made of bile) go back and forth between brush border and chyme

5. Embryology
Zygote (fertilization in fallopian tubes); morula (up to 8 cells - undifferentiated ie totipotent); blastocyst (4+ days - implants into uterus; HCG secretion stims corpus luteum; gradually placenta replaces HCG as estrogen/progest source; cells not t
Prophase II: no crossing over b/c there are no homologous chromosomes; nuclear envelope dissolves Metaphase II: chromosomes line up at metaphase plate Anaphase II: sister chromatids separate - migrate to opp poles Telophase II: nuclear envelope reap
Lumen (ie continuous w/body cavity) and cytosol
Inactive: rhodopsin is activated by photons; activated rhodopsin hyperpolarizes rod cells - causes photobleaching

6. inhibin secreted by
Eg spinal nerve - cranial nerve; Not All Nervous Tissue In Brain - SC Is CNS Tissue
It is the animal counterpart of starch; it is more highly- branched - thus releases more glucose monomers upon repeated hydrolysis than starch
Testes>Semeniferous tubules>Sertoli cells; feedback on AP FSH production
Secondary oocyte (stim'd by LH stimulation of theca cells causing release of testosterone - converted to estradiol; eventually brings about luteal surge -->EQUATIONAL DIVISION-->ovum released during ovulation into fallopian tube; burst follicle becom

7. E storage per unit mass
Carbohydrates are highly hydrated: one water mol per carbon mol - fats are anhydrous: contain more reduced carbons per unit mass - altogether fats contain 6X energy per unit mass
Night vision
Has memb - bound organelles - etc...
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum

8. small intestine=
Hormones --->stimulate exocrine glands - acetylcholine (increases all secretion of gastric pits) - gastrin (from G cells) - histamine (increases HCl secretion of parietals) ...Ach increases all secretions; gastrin increases gastric acid (parietal cel
Duodenum (wraps around pancreas; most digestion occurs here) - jejunum (pH 7-9; 2m) - ileum
In liver (RBC recycling of heme); stored in gall bladder; released via cystic duct to common bile duct (shared w/liver); common bile duct joins up with panc duct...everything feeds into the sm intest at the ampulla of vater**
Pancreatic duct (made of acinar cells?)

9. At post - two weeks ovulation
Corpus luteum degrades into corpus albicans
Ventrally (picture skeletal vertebrae)
Sensory (afferent - dorsal) - motor (efferent - ventral)
Lots of energy; eg neurons have hi glucose need for 3Na out 2K in ATPase; stomach epithel tiss needs E for parietal cells to pump protons into lumen and bicarbonate into blood

10. sporic life cycle
**NO*** lipase digests fat; no bonds broken by bile; only opens up more SA for lipase
(diploid and haploid individuals = ALTERNATION of GENERATIONS) a fusion of gametic and zygotic life cycles
Presence of fat - prot in duodenum causes release of **gastric inhibitory peptide**; result is slower stomach contraction; slower emptying into duod thru pyloric sphincter (slower chyme secretion); more time to properly digest - absorb nutrients
Mouth - esophagus - stomach - duodenum - jejunum - ileum - ascending colon - transverse colon - descending colon - sigmoid colon - rectum - anus

11. From that point...
AAs enter bloodstream for uptake by all cells (esp liver). If intracellular prot conc is at max AAs can be converted to fats or glucose via gluconeogenesis. Byproduct of gluconeo is ammonia --->urea.
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)
Zygote (morula) composed of eight or more cells; All cells at this stage are TOTipOTENT STEM Cells: do not grow - form by cleavage
Hormones --->stimulate exocrine glands - acetylcholine (increases all secretion of gastric pits) - gastrin (from G cells) - histamine (increases HCl secretion of parietals) ...Ach increases all secretions; gastrin increases gastric acid (parietal cel

12. What surrounds the hydrophilic heads of the new TAGs
Prophase II: no crossing over b/c there are no homologous chromosomes; nuclear envelope dissolves Metaphase II: chromosomes line up at metaphase plate Anaphase II: sister chromatids separate - migrate to opp poles Telophase II: nuclear envelope reap
SYMP: spinal cord --->paravetebral ganglion PARA: spinal cord - brain; cell processes --->ganglion near effector organ (preganglionic neurons) extend outside of spinal cord to synapse at ganglia - go on along postganglionic neurons
Apoproteins attach to outside of globules; these move to Golgi and are released into interstitial fluid via exocytosis as chylomicrons --->most go to lacteal system
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes

13. Determination is different than differentiation
via symport - secondary transport (ie by pre - established - ATP- intensive) with Na gradient into enterocyte......with no Na gradient (ie without ATP) carbohydrate monomers could not be transported in
Systems (eg digestive system consists of many organs)
Determination is a pre - programmed fate - differentiation is the actual materialization of that fate
5

14. What do villli do
Polysaccharides w/proteoglycans attached = glycosaminoglycans; often give pliability
- enterocytes w/ *microvilli brush border*: membrane - bound digestive enzymes for carbs - fats - nucleic acids - goblet cells: secrete mucous - Deep between villi are the intestinal exocrine glands - the crypts of Lieberkuhn - which secrete pH 7.6 i
CARB- Digesting: dextrinase (polysachs produced by hydrolysis of starch) - maltase (glucose - glucose) - sucrase (glucose - fructose) - lactase (galactose - glucose) - Protein- Digesting: peptidases - NUCLEOTIDE- Digesting: nucleosidases
Increase surface area of sm intestine; this improves digestion (enzymes adsorbed to villi) and absorption

15. How is the follicle developed during oogenesis
Arrested at primary oocyte; hypothalamus GnRH->FSH released at puberty stims granulosa cell development; granulosa secrete zona pellucida = primary follicle
Stomach - sm intest - spleen - pancreas from the hepatic portal vein...all blood that passes thru liver go thru flattened spaces called the ***hepatic sinusoids -->hepatic vein --->vena cava
Tight regulation of parietal cells needed b/c gastric acid secretion is E- intensive; parietal cells are hi in mitochons
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum

16. Where does the juxtaglomerular apparatus come into play...renin --->inc angiotensins -->inc aldosterone - ups BP
Spinal cord ventral horns; somatic motor neurons use acetylcholine for NTs (voluntary)
Chyme (by combined activity of exocrine glands)
Monitors filtrate pressure in the distal tubule; has specialized cells (granular cells) that secrete an enzyme (**renin); renin initiates regulatory cascade that produces angiotensin I - II - III that stim adrenal cortex to secrete aldosterone... ...
Eukaryotes

17. FLAT PG: hGH aka somatotropin
Increases surface area of food ball (bolus)
Pancreatic duct (made of acinar cells?)
Know that 90% digestion - absorption occurs in sm intestine --> fine breakdown of carbs - fat - prots
Peptide; stims growth of nearly all cell of body; all other anterior pituitary horms have specific targets; upregulates anabolic pathways; use of fat for energy goes up (fat - burning); increases AA transport across cell membrane (nutrient uptake)

18. What is a toxic byproduct of gluconeogenesis from proteins
Ammonia; must be converted to urea by liver and excreted in urine by kidney
Fallopian tubes
Tight regulation of parietal cells needed b/c gastric acid secretion is E- intensive; parietal cells are hi in mitochons
Lens will be rounded; contraction of the lens (ie focusing) is done by ciliary muscle

19. thyroid hormones: Not All One Kind of HORM
In mouth - breakdown of starch into polysaccharides
Lower blood pH
Eukaryotes
Calcitonin (peptide; lowers blood Ca); T3/T4 (tyrosine - derived; increase basal metabolic rate); T4= thyroxine

20. Where are these exocrine glands located
In gastric pits; secretions combine into gastric juice
HCl; secreted by parietal cells under stim by gastrin
Spinal cord ventral horns; somatic motor neurons use acetylcholine for NTs (voluntary)
Liposome has phospholipid bilayer

21. What is secreted into filtrate by cells of the proximal tubule?
Sensory neurons are affector; motor neurons are effector // dorsal afferent (dorsal - Back- side of spinal cord carries sensory signals to brain; ventral effector
Hydrostatic pressure forces some plasma thru *fenestrations of the glomerular endothelium* and into Bowman's capsule; B.C. is continuous with lumen of nephron
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics
Conjunction of cell body w/axon

22. in fat and liver cells monoglycerides and ffas are once again
Ups bicarbonate secretion by pancreas; raises pH to 6.0
Small amounts of hydrolyzed phospholipids and cholesterol: like other fat mols these can diffuse thru enterocyte membrane
Trypsin(- ogen; activates other panc enzymes after it is activated by enterokinase of sm intest); chymotrypsin - amylase - lipase
Reconstituted into TAGs at smooth ER; first stop for most digested fat is liver

23. microvilli: increase SA of enterocyte; have hi conc of digestive enzymes

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24. parathyroid hormone
Increases blood Calcium
Interneurons working to integrate signals received from the peripheral nervous system (sense organs)
Mediate complex cell processes thru eg phosphorylation via secondary messenger (G protein) systems = signal transduction pathway - GPCR (G protein coupled receptor)
'Increased absorptive area is useful because digested nutrients (including sugars and amino acids) pass into the villi through diffusion - which is effective only at short distances. In other words - **increased surface area (in contact with the flui

25. Where does fertilization occur
Apoproteins attach to outside of globules; these move to Golgi and are released into interstitial fluid via exocytosis as chylomicrons --->most go to lacteal system
Steroid; target tissue is distal convoluted tubule of nephron and collecting duct; increases blood mineral concentration; potassium - protons secreted (blood pH increases); sodium - chloride reabsorbed (BP increases)
- parietal cells (**oxyntic= hi oxygen consumption - hi E??): have hi conc mito; need lots of energy to create proton gradient; thus - responsible for extremely harsh pH conditions in stom; denaturing conditions - chief cells (peptic): synthesize pep
Fallopian tubes

26. fat digestion is time - intensive
Needs time for bile - lipase - micelle migration - enterocyte uptake
Where lipoprotein lipase hydrolyzes TAGs; products diffuse into target tiss (mostly liver - adipose tissue)
Lumen (ie continuous w/body cavity) and cytosol
Peripheral nervous sys

27. Spinal cord horns (thick knobs) point
Polysaccharides w/proteoglycans attached = glycosaminoglycans; often give pliability
Ventrally (picture skeletal vertebrae)
Gonadotropin releasing hormone - GnRH
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes

28. A pinpoint iris is contracted or uncontracted
Result is proton secreted into lumen - bicarbonate into interstitial fluid (diffuses into blood); result is also increased blood pH and decreased pH stomach
Uncontracted: parasymp (eg opoid use)
Which is why lactase - maltase - dextrinase - sucrase are on brush border
Apoproteins attach to outside of globules; these move to Golgi and are released into interstitial fluid via exocytosis as chylomicrons --->most go to lacteal system

29. almost all exocytosed proteins pass through this
Alpha cells; stims gluconeogenesis in liver; acts via cAMP second messenger
Four 23 N daughter cells are formed from one 46 2N mother (germ - line) cell; four haploid gametes
Smooth ER
Development of placenta begins with implantation; eventually - by end of first trimester - placenta will replace corpus luteum and its estrogen/progest secretions

30. Human chorionic gonadotropin...
cornea (1.4 refractory index; bends light) - pupil (size of pupil is determined by contraction state of the iris) - aqueous humor
Secreted by implanted egg; HCG prevents degeneration of the corpus luteum; HCG in blood/urine is first sign of pregnancy
Transfer signals from neuron - neuron; 90% of neurons are interneurons
Where lipoprotein lipase hydrolyzes TAGs; products diffuse into target tiss (mostly liver - adipose tissue)

31. position of AP...
Below hypothalamus
Steroid; target tissue is distal convoluted tubule of nephron and collecting duct; increases blood mineral concentration; potassium - protons secreted (blood pH increases); sodium - chloride reabsorbed (BP increases)
Peptide; responsible for luteal surge (driven in part by LH-->testosterone -->estradiol -->LH positive feedback); results in ovulation (follicle bursting) - releasing egg into fallopian tube/oviduct
Size of fist; two kidneys; have cortex (steroid hormones) and medulla (catecholamines) - receives about 20% of cardiac output - blood travels down arteries - up veins -'urine is created by the kidney and emptied into the renal pelvis - which is empti

32. Embryology
Eukaryotes
Zygote - morula (first four days) - blastocyst (4 day+; implants in uterine lining) - gastrula (2 week) - neurula (3 week)...
Night vision
Peptide; responsible for luteal surge (driven in part by LH-->testosterone -->estradiol -->LH positive feedback); results in ovulation (follicle bursting) - releasing egg into fallopian tube/oviduct

33. parathyroid hormones
Glycosaminoglycans - prots - AAs - lipids
Parathyroid hormone (peptide; increases blood Ca); thus - might increase osteoclast/decrease osteoblast activity
'Increased absorptive area is useful because digested nutrients (including sugars and amino acids) pass into the villi through diffusion - which is effective only at short distances. In other words - **increased surface area (in contact with the flui
Ectoderm: outer coverings - nervous system Mesoderm: between covering ie musc - bone - etc - endoderm: digestive tract - viscera

34. 80-90% fat absorbed this way
Stims release of tyrosine - derived horms T3/T4 (increase basal metabolic rate); TSH increases thyroid cell size - number - rate of T3/T4 synth -----> thus - iodine deficiency causes swollen thyroid due to lack of neg feedback onto TSH in anterior pi
Processes: axons - dendrites
Glucocorticoid (cortisol); mineralocorticoid (aldosterone)
Moves thru lymph sys; emptied into large veins (thus into bloodstream) of the neck at Thoracic duct

35. Creating gradients requires what?
(diploid and haploid individuals = ALTERNATION of GENERATIONS) a fusion of gametic and zygotic life cycles
Lots of energy; eg neurons have hi glucose need for 3Na out 2K in ATPase; stomach epithel tiss needs E for parietal cells to pump protons into lumen and bicarbonate into blood
Break down TAGs to monoglycerides and free fatty acids
Which is why lactase - maltase - dextrinase - sucrase are on brush border

36. Liver Functions
Zygote (morula) composed of eight or more cells; All cells at this stage are TOTipOTENT STEM Cells: do not grow - form by cleavage
Gastrulation occurs: formation of three primary germ layers = differentiation
'The hepatic portal vein is not a true vein - because it does not conduct blood directly to the heart. It is a vessel in the abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver.'
Stores blood: when expanded liver serves as blood reservoir for body - filters blood: Kupfer cells phagocytize bacteria picked up from intestines - destroys bad RBCs: also done by Kupfer cells - detoxifies blood: detoxified chemicals are excreted eit

37. FLAT PG: LH
Which is why lactase - maltase - dextrinase - sucrase are on brush border
Peptide; responsible for luteal surge (driven in part by LH-->testosterone -->estradiol -->LH positive feedback); results in ovulation (follicle bursting) - releasing egg into fallopian tube/oviduct
Faces the lumen
Nourishes follicle growth; stimulates granulosa cell growth around primary oocyte at puberty = primary follicle; also - stimulates Sertoli cells in males

38. What are the memb - bound enzymes of the brush border?
The wall of the body or of a body cavity or hollow structure
Posterior pituitary hormone; acts on uterus - mammary glands; causes uterine contractions - milk ejection
Liposome has phospholipid bilayer
CARB- Digesting: dextrinase (polysachs produced by hydrolysis of starch) - maltase (glucose - glucose) - sucrase (glucose - fructose) - lactase (galactose - glucose) - Protein- Digesting: peptidases - NUCLEOTIDE- Digesting: nucleosidases

39. when cells hit their limit for prot storage...
AAs can be burned for energy or converted to fat for storage
Apoproteins attach to outside of globules; these move to Golgi and are released into interstitial fluid via exocytosis as chylomicrons --->most go to lacteal system
Arrested at primary oocyte; hypothalamus GnRH->FSH released at puberty stims granulosa cell development; granulosa secrete zona pellucida = primary follicle
Fallopian tubes

40. Where does blood to be filtered by kidney enter the nephron?

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41. What happens when rod cell is depolarized
Prophase II: no crossing over b/c there are no homologous chromosomes; nuclear envelope dissolves Metaphase II: chromosomes line up at metaphase plate Anaphase II: sister chromatids separate - migrate to opp poles Telophase II: nuclear envelope reap
Night vision
5
Development of placenta begins with implantation; eventually - by end of first trimester - placenta will replace corpus luteum and its estrogen/progest secretions

42. Anatomy of the villi
The wall of the body or of a body cavity or hollow structure
Nervous - muscle - epithelial (defines inner/outer) - connective (extensive matrices)
Contain capillary network - lymph vessels (lacteals)
Fovea (highest amount of cones)

43. What if large intestine isn't working well
Smaller - more water soluble short - chain FAs go directly to bloodstream at villi capillaries
FAT=9 cal per gram Carbs=4.5 cal per gram - Prot=4 cal per gram - these seem to be for anhydrous forms
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)
Diarrhea: excess water loss in feces; poor absorption of vitamins - minerals

44. Adrenal cortex hormones (STEROIDS)
Peptide; prolactin promotes milk production; prolactin release is stimulated by act of suckling - which in turn inhibits menstrual cycle
Glucocorticoid (cortisol); mineralocorticoid (aldosterone)
Nitrogen
An ether phospholipid; hi conc in myelin; thus - hi conc in heart tiss - nervous tiss

45. How do parietal cells work ** (involves CO2)
Pancreatic duct (made of acinar cells?)
Notochord (mesoderm) induces ectoderm to thicken into neural plate --->neural tube --->spinal cord
Result is proton secreted into lumen - bicarbonate into interstitial fluid (diffuses into blood); result is also increased blood pH and decreased pH stomach
The crypts of Lieberkuhn: sm intestine pH is not right; brush border enzs won't work right

46. Polypeptides are formed with what kind of reaction?
The renal corpuscle
Mediate complex cell processes thru eg phosphorylation via secondary messenger (G protein) systems = signal transduction pathway - GPCR (G protein coupled receptor)
Receive signals from receptor cell w/ ability to interact with its environment; 99% sensory input is discarded
Dehydration reaction; broken apart with enzyme - catalyzed hydrolysis

47. 90% digestion - absorption occurs in...
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
Smaller - more water soluble short - chain FAs go directly to bloodstream at villi capillaries
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics
Break down TAGs to monoglycerides and free fatty acids

48. Sensory - motor neurons are part of which nervous system
Secreted by delta cells of Islets of langerhans; inhibits insulin and glucagon; slows digestion
Conjunction of cell body w/axon
Peripheral nervous sys
Going up - water - impermeable: salt is actively pumped out - filtrate osmolarity goes down as salt leaves

49. SYMP neurons originate in= PARA neurons originate in=
SYMP: spinal cord --->paravetebral ganglion PARA: spinal cord - brain; cell processes --->ganglion near effector organ (preganglionic neurons) extend outside of spinal cord to synapse at ganglia - go on along postganglionic neurons
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr
Contains lysozyme - which regulates bacteria within intestine; breaks down peptidoglycans (**bact wall); innate immunity
Somatic sensory = dorsal root ganglia (outside spinal cord); somatic effector = ventral horns of spinal cord

50. examples of different cavities... (compartments for viscera)
pericardial cavity - pleural cavity (contains lungs) - peritoneal cavity (abdominal)
Moves down thru esophageal sphincter
ER
Notochord (mesoderm) induces ectoderm to thicken into neural plate --->neural tube --->spinal cord

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