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MCAT Prep - 2

Subjects : mcat, science

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. protein absorption at enterocyte
Amino acid monomers - di - tri absorbed by symport at enterocyte; each AA has slightly diff mechanism; from entero - AAs enter bloodstream where they are taken up by all cells of the body - esp the liver by active or facilitated transport (NEVER PASS
Mediate complex cell processes thru eg phosphorylation via secondary messenger (G protein) systems = signal transduction pathway - GPCR (G protein coupled receptor)
Gastrulation occurs: formation of three primary germ layers = differentiation
Ammonia; must be converted to urea by liver and excreted in urine by kidney

2. from thoracic duct - chylomicrons stick to capillary walls...
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr
sucrose (gluc+fruc) - lactose (gluc+galactose) - starch (gluc+gluc)
**only para effectors have muscarinic receptors; symp effectors are adrenergic (epi - norepi); **neuromuscular junction uses nicotinic receptors
Where lipoprotein lipase hydrolyzes TAGs; products diffuse into target tiss (mostly liver - adipose tissue)

3. liver receives blood from...
***nicotinic is ionotropic; muscarinic is GPCR
Stomach - sm intest - spleen - pancreas from the hepatic portal vein...all blood that passes thru liver go thru flattened spaces called the ***hepatic sinusoids -->hepatic vein --->vena cava
Peptide; responsible for luteal surge (driven in part by LH-->testosterone -->estradiol -->LH positive feedback); results in ovulation (follicle bursting) - releasing egg into fallopian tube/oviduct
Peripheral nervous sys

4. smooth ER main function
Chylomicrons are much bigger
Synthesizes lipids (including steroids); detoxifies drugs; is continuous with lumen
23 N; 23 chromosomes and haploid (no homologous chromosomes); each chromosome has two sister chromatids Male: primary spermatocyte -->REDUCTIONAL DIVISION (first stim'd at puberty by GnRH - LH-->secondary spermatocyte Female: primary oocyte (arreste
Arrested at primary oocyte; hypothalamus GnRH->FSH released at puberty stims granulosa cell development; granulosa secrete zona pellucida = primary follicle

5. Beta - oxidation in liver produces...
Contains hydrolytic enzymes; thus - digests endocytosed substances; derived from golgi
Ketone bodies; thus excessive reliance on fat for energy (eg low carb diets) results in ketosis; blood acidity increases
Lots of energy; eg neurons have hi glucose need for 3Na out 2K in ATPase; stomach epithel tiss needs E for parietal cells to pump protons into lumen and bicarbonate into blood
Nitrogen

6. 90% digestion - absorption occurs in...
Apoproteins attach to outside of globules; these move to Golgi and are released into interstitial fluid via exocytosis as chylomicrons --->most go to lacteal system
Small intestine; duodenum is smallest and does most DIGESTION; jejunum is medium and does most ABSORPTION; ileum is biggest and does most absorption along with jejunum
Liver breaks down glycogen (glycogenolysis); at hi blood sugar it builds up glycogen (glycogenesis)
Peptides

7. week three: neurulation; mesoderm induces ectoderm; thus - NEURULATION INVOLVES SC Development - at week three
= catecholamines; fight/flight; vasoconstrictors of internal organs - skin; vasodilators of skel musc; also considered stress hormones; epinephrine - norepinephrine
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr
Many modern drugs are ligands for GPCRs
Notochord (mesoderm) induces ectoderm to thicken into neural plate --->neural tube --->spinal cord

8. review: parietals secrete intrinsic factor...
After 4 day+ - morula cells have formed fluid - filled ball (blastocyst); this implants in uterus at day 5-7; blastocyst is made up of EMBRYONIC STEM Cells; once implanted w/blastocyst - female is pregnant
Comes into play in the large intestine - where vitamin b12 is absorbed w/help of E. coli; thus; must travel thru bloodstream to large intestine
Photon (hv)- rhodopsin - conformation change - GPCR- Na less permeable - hyperpolarized rod cells - generates AP= photobleaching at visible light wavelengths (390-700nm)
Oxidizes macromolecules; breaks down very long - chain FAs by beta - oxidation; products (acetyl - CoA) are shuttled to mitochondrion for citric acid cycle

9. hypothalamus controls anterior pit - posterior pit release with inhibitory/releasing hormones of its own; these should have fairly self - explanatory names
Hypothalamus --->AP--->target tissues eg TSH - thyroid - T3/T4 release - increase basal metabolic rate
Estradiol
Sudiferous (sweat) - sebaceous - digestive (bile - pancreatic enzs) - mucosal
About 7.2

10. micelles vs liposomes
Liposome has phospholipid bilayer
On to the distal tubule where sodium - calcium are reabsorbed - protons - bicarbonate - potassium are secreted via membrane transport proteins
Membrane - bound - endocytosed bodies
Increase surface area of sm intestine; this improves digestion (enzymes adsorbed to villi) and absorption

11. A pinpoint iris is contracted or uncontracted
Comes into play in the large intestine - where vitamin b12 is absorbed w/help of E. coli; thus; must travel thru bloodstream to large intestine
Uncontracted: parasymp (eg opoid use)
***starting with adipose tiss: FFAs are transported in the blood by albumin (major component of blood plasma); one albumin typically carries three fatty acid molecules but can hold up to 30 FAs
Number of centromeres - Not number of chromatids eg - two sister chromatids connected by one centromere = one chromosome

12. Both divisions (somatic - autonomic) of PNS consist of...
Follicular phase: primary - secondary - ovulation (1 week) luteal phase: ovulation - thickening of uterine lining w/corpus luteum secretion - corpus luteum degrades (2 weeks) flow: shedding of uterine lining (4 days)
Posterior pituitary hormone; acts on uterus - mammary glands; causes uterine contractions - milk ejection
**only para effectors have muscarinic receptors; symp effectors are adrenergic (epi - norepi); **neuromuscular junction uses nicotinic receptors
Sensory (afferent - dorsal) - motor (efferent - ventral)

13. in mammals - gastrulation involves formation of the
Sympathetic: dilates pupil (for night hunting)
PNS- Somatic - afferent (dorsal root ganglion) + efferent (ventral horns) PNS- ANS- afferent (sensors on viscera) + SYMP - PARA pre - post - ganglionic neurons
= catecholamines; fight/flight; vasoconstrictors of internal organs - skin; vasodilators of skel musc; also considered stress hormones; epinephrine - norepinephrine
Primitive streak - which consists of cells of the MESODERM ****

14. Sensory neuron cell bodies vs. somatic motor cell bodies
SYMP: spinal cord --->paravetebral ganglion PARA: spinal cord - brain; cell processes --->ganglion near effector organ (preganglionic neurons) extend outside of spinal cord to synapse at ganglia - go on along postganglionic neurons
Adrenal gland -- AC: steroids (cortisol - aldosterone); AM: catecholamines (epi - norepi); Islets of langerhans: peptides (insulin/glucagon) ANTAGONISTS: calcitonin (thyroid - peptide lowers Ca in blood); parathyroid hormone - peptide - vitamin D pat
After morula - with blastocyst (+8 cell count)--->totipotent to embryonic stem cell and so on
Somatic sensory = dorsal root ganglia (outside spinal cord); somatic effector = ventral horns of spinal cord

15. chylomicron concentration in blood after meal
Sympathetic: dilates pupil (for night hunting)
Faces the lumen
Inactive: rhodopsin is activated by photons; activated rhodopsin hyperpolarizes rod cells - causes photobleaching
Peak at 1-2hr after meal; chylomicrons themselves have half - life of about 1hr after formation in enterocytes

16. Failure of apoptosis can result in
Amino acid monomers - di - tri absorbed by symport at enterocyte; each AA has slightly diff mechanism; from entero - AAs enter bloodstream where they are taken up by all cells of the body - esp the liver by active or facilitated transport (NEVER PASS
Secondary follicle: Theca cells differentiate from interstitial tissue - surround follicle - secrete testosterone when stimd by LH (compare to Leydig cells)
Cancer; apop can be programmed cell death; mitochon can play important role in apop
Vitamin K - b12 - thiamin - riboflavin

17. main point of fat transport...
Sudiferous (sweat) - sebaceous - digestive (bile - pancreatic enzs) - mucosal
Fat is insoluble in blood and requires a carrier like lipoproteins (vLDL...HDL) or albumins; ...vLDL has hi triglycerides - hi cholesterol
Zygote (fertilization in fallopian tubes); morula (up to 8 cells - undifferentiated ie totipotent); blastocyst (4+ days - implants into uterus; HCG secretion stims corpus luteum; gradually placenta replaces HCG as estrogen/progest source; cells not t
Thru tight junctions by favorable osmotic gradient

18. important because in meiosis germ - line cells begin as 46 2N w/ 23 pairs of homologous chromosomes which are replicated in S phase of interphase to 23 pairs of sister chromatids = still 46 2N
Growth 1 (G1) phase: STRUCTURAL ProteinS - ENZYMES; This is a very active period - where the cell synthesizes its vast array of proteins - including the enzymes and structural proteins it will need for growth. In G1 stage each of the chromosomes cons
Regulated by gastrointestinal horms
Liposome has phospholipid bilayer
Prod of steroid hormones in testes - ovaries

19. AP- peptides (FSH - LH - ACTH - TSH - prolactin - hGH); PP- peptides (ADH - oxytocin); thyroid - peptide *and* tyr - derived (T3/T4 - calcitonin); parathyroid - peptide (PTH; raise blood Ca via pathway involving vitamin D)
Contains lysozyme - which regulates bacteria within intestine; breaks down peptidoglycans (**bact wall); innate immunity
Sensory neurons are affector; motor neurons are effector // dorsal afferent (dorsal - Back- side of spinal cord carries sensory signals to brain; ventral effector
Secondary spermatocyte (stim'd by FSH from Sertoli cells -->EQUATIONAL DIVISION-->spermatid - which matures further into spermatozoa; released into semeniferous tubule; transported to epididymis
Adrenal gland -- AC: steroids (cortisol - aldosterone); AM: catecholamines (epi - norepi); Islets of langerhans: peptides (insulin/glucagon) ANTAGONISTS: calcitonin (thyroid - peptide lowers Ca in blood); parathyroid hormone - peptide - vitamin D pat

20. What is secreted into filtrate by cells of the proximal tubule?
Primitive streak - which consists of cells of the MESODERM ****
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum
AAs enter bloodstream for uptake by all cells (esp liver). If intracellular prot conc is at max AAs can be converted to fats or glucose via gluconeogenesis. Byproduct of gluconeo is ammonia --->urea.
Drugs - toxins - bile pigments (color the urine) - uric acid - antibiotics

21. Embryology
Liver Functions pt. 2 - Carb metabolism: blood is sent straight to liver from sm intest thru portal vein; liver is control center for blood glucose; _______________ - fat metabolism: oxidizes fat for energy by beta - oxidation - forms most lipoprotei
Zygote (fertilization in fallopian tubes); morula (up to 8 cells - undifferentiated ie totipotent); blastocyst (4+ days - implants into uterus; HCG secretion stims corpus luteum; gradually placenta replaces HCG as estrogen/progest source; cells not t
RBCs - large proteins; What does enter is called the filtrate
Has memb - bound organelles - etc...

22. amylase acts where on carbs
Somatic sensory = dorsal root ganglia (outside spinal cord); somatic effector = ventral horns of spinal cord
Salivary amylase (weak); sm intest amylase (breaks down large polysaccharides)
Glucose and ketone bodies (not from glycogen stores)
Size of fist; two kidneys; have cortex (steroid hormones) and medulla (catecholamines) - receives about 20% of cardiac output - blood travels down arteries - up veins -'urine is created by the kidney and emptied into the renal pelvis - which is empti

23. Human chorionic gonadotropin...
Meiosis creates germ cells
Abdominal cavity - which is coated in serous fluid
Lots of water - minerals (electrolyte balance) - vitamins (aided by gut bacteria)
Secreted by implanted egg; HCG prevents degeneration of the corpus luteum; HCG in blood/urine is first sign of pregnancy

24. when cells hit their limit for prot storage...
Presence of fat - prot in duodenum causes release of **gastric inhibitory peptide**; result is slower stomach contraction; slower emptying into duod thru pyloric sphincter (slower chyme secretion); more time to properly digest - absorb nutrients
Work together to emulsify fats: bile works as a detergent to increase SA of the fat; increased SA gives more substrate to lipase for digestion
Lens will be rounded; contraction of the lens (ie focusing) is done by ciliary muscle
AAs can be burned for energy or converted to fat for storage

25. from the loop of henle...
Stims release of tyrosine - derived horms T3/T4 (increase basal metabolic rate); TSH increases thyroid cell size - number - rate of T3/T4 synth -----> thus - iodine deficiency causes swollen thyroid due to lack of neg feedback onto TSH in anterior pi
On to the distal tubule where sodium - calcium are reabsorbed - protons - bicarbonate - potassium are secreted via membrane transport proteins
Signal picked up by sensory cell - goes thru dorsal root ganglion to SC - may continue to interneurons in brain or simple reflex arc in SC - brain integrates info and decides (voluntary) response - travels back down SC to appropriate ventral root gan
Chyme (by combined activity of exocrine glands)

26. What is a plasmalogen?
Sympathetic: dilates pupil (for night hunting)
Renal pyramids --->renal calyx-->renal pelvis -->ureter -->urethra
An ether phospholipid; hi conc in myelin; thus - hi conc in heart tiss - nervous tiss
Normally contracted

27. large intestine E. coli aid absorption of...
Estradiol
Vitamin K - b12 - thiamin - riboflavin
Transfer signals from neuron - neuron; 90% of neurons are interneurons
Di - tri - peptides; inside enterocytes are hydrolyzed to amino acids

28. Where are these exocrine glands located
Ectoderm: outer coverings - nervous system Mesoderm: between covering ie musc - bone - etc - endoderm: digestive tract - viscera
'Microvilli function as the **primary surface of nutrient absorption in the gastrointestinal tract**. Because of this vital function - the microvillar membrane is packed with enzymes that aid in the breakdown of complex nutrients into simpler compoun
In gastric pits; secretions combine into gastric juice
Trypsin(- ogen; activates other panc enzymes after it is activated by enterokinase of sm intest); chymotrypsin - amylase - lipase

29. Where does fertilization occur
Small amounts of hydrolyzed phospholipids and cholesterol: like other fat mols these can diffuse thru enterocyte membrane
Fallopian tubes
1) by integral ion channels 2) transmitted by second messenger system
Increases solute conc and osmotic pressure of the ***medulla

30. size of chylomicrons (fat + apoproteins) vs lipoproteins ('cholesterol')
Chylomicrons are much bigger
'visceral organs develop adjacent to a cavity and invaginate into the bag - like coelom'
About 7.2
***nicotinic is ionotropic; muscarinic is GPCR

31. Peritoneal refers to...
PNS- Somatic - afferent (dorsal root ganglion) + efferent (ventral horns) PNS- ANS- afferent (sensors on viscera) + SYMP - PARA pre - post - ganglionic neurons
'The hepatic portal vein is not a true vein - because it does not conduct blood directly to the heart. It is a vessel in the abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver.'
Abdominal cavity - which is coated in serous fluid
Lower blood pH

32. Between meals most fats appear in blood as
Homologous chromosomes line up w/ attachment of spindle fibers/microtubule polymers to centromeres via kinetochores; identical in appearance under light microscope to metaphase of mitosis
Where lipoprotein lipase hydrolyzes TAGs; products diffuse into target tiss (mostly liver - adipose tissue)
Lipoproteins; albumin carries free fatty acids when fat is mobilized from adipose tissue - etc
Determined by whether in front of or behind the lens

33. Some epithelial cells are... others...
- enterocytes w/ *microvilli brush border*: membrane - bound digestive enzymes for carbs - fats - nucleic acids - goblet cells: secrete mucous - Deep between villi are the intestinal exocrine glands - the crypts of Lieberkuhn - which secrete pH 7.6 i
Lens will be rounded; contraction of the lens (ie focusing) is done by ciliary muscle
Smooth ER
Fallopian tubes

34. oxytocin
Sensory (afferent - dorsal) - motor (efferent - ventral)
Maintains hi estrogen levels; body does not recognize luteal surge - ovulation does not occur; hi progesterone can lessen shedding by thickening the uterine lining
Posterior pituitary hormone; acts on uterus - mammary glands; causes uterine contractions - milk ejection
Nourishes follicle growth; stimulates granulosa cell growth around primary oocyte at puberty = primary follicle; also - stimulates Sertoli cells in males

35. In general - parietal=
The wall of the body or of a body cavity or hollow structure
Presence of fat - prot in duodenum causes release of **gastric inhibitory peptide**; result is slower stomach contraction; slower emptying into duod thru pyloric sphincter (slower chyme secretion); more time to properly digest - absorb nutrients
To the organelle w/ lumen: smooth ER; they are resynthesized into TAGs
HCl; secreted by parietal cells under stim by gastrin

36. Kidney physiology...

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37. sensory (afferent)/interneurons/motor (efferent)
Neurons may perform one of three functions....
Liposome has phospholipid bilayer
Water flows from the tubule - concentrating the filtrate - raising BP
From lumenal (apical) to enterocyte to basolateral side of epithelial tissue

38. Where do pancreatic secretions take effect
(diploid organism) humans are part of gametic life cycle ie produce gametes; diploid germ - line stem cells undergo meiosis to form haploid gametes
Food is digested from mouth to stomach (denaturation by gastric acid - digested by pepsin) to duodenum (more digestion); then absorption occurs in jejunum and ileum
On the chyme exiting the stomach and entering duodenum thru the pyloric sphincter
Salivary amylase (weak); sm intest amylase (breaks down large polysaccharides)

39. Adrenal medulla hormones (TYR- DERIVED)
Liver is the control center for blood glucose; is fed by portal vein from sm intest
= catecholamines; fight/flight; vasoconstrictors of internal organs - skin; vasodilators of skel musc; also considered stress hormones; epinephrine - norepinephrine
Smaller - more water soluble short - chain FAs go directly to bloodstream at villi capillaries
Organs

40. food in duod stims release of gastrointestinal hormones
Follicular phase: primary - secondary - ovulation (1 week) luteal phase: ovulation - thickening of uterine lining w/corpus luteum secretion - corpus luteum degrades (2 weeks) flow: shedding of uterine lining (4 days)
Gall bladder - pancreatic secretions increase - arrive via ampulla of vater (duct glands); insulin secretion increases (fed state; ductless glands)
Inner lining of circulatory system
= catecholamines; fight/flight; vasoconstrictors of internal organs - skin; vasodilators of skel musc; also considered stress hormones; epinephrine - norepinephrine

41. keep in mind that enterocyte is like a regular euk cell
Has memb - bound organelles - etc...
'The hepatic portal vein is not a true vein - because it does not conduct blood directly to the heart. It is a vessel in the abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver.'
Stomach - sm intest - spleen - pancreas from the hepatic portal vein...all blood that passes thru liver go thru flattened spaces called the ***hepatic sinusoids -->hepatic vein --->vena cava
Follicular phase: primary - secondary - ovulation (1 week) luteal phase: ovulation - thickening of uterine lining w/corpus luteum secretion - corpus luteum degrades (2 weeks) flow: shedding of uterine lining (4 days)

42. In effect LH - FSH stimulate
Trypsin(- ogen; activates other panc enzymes after it is activated by enterokinase of sm intest); chymotrypsin - amylase - lipase
Lower blood pH
Pancreas; active at sm intestinal pH; hydrolyzes peptide bonds of (pepsin - digested) peptides
Prod of steroid hormones in testes - ovaries

43. calcitonin

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44. Gland: ovaries
Estrogen: steroid; stims LH in luteal surge; causes growth of female sex organs progesterone: prepares/maintains uterus for pregnancy
Follicular phase: primary - secondary - ovulation (1 week) luteal phase: ovulation - thickening of uterine lining w/corpus luteum secretion - corpus luteum degrades (2 weeks) flow: shedding of uterine lining (4 days)
Secondary follicle: Theca cells differentiate from interstitial tissue - surround follicle - secrete testosterone when stimd by LH (compare to Leydig cells)
Changes: volume of filtrate does not change: osmolarity of filtrate --->reabsorbed ions like sodium carry water across membrane

45. pancreas secretes enzymes via
Posterior pituitary hormone; acts on uterus - mammary glands; causes uterine contractions - milk ejection
Renal pyramids --->renal calyx-->renal pelvis -->ureter -->urethra
Prod of steroid hormones in testes - ovaries
Pancreatic duct (made of acinar cells?)

46. only monosaccharides are absorbed
Lens will be rounded; contraction of the lens (ie focusing) is done by ciliary muscle
Excretes waste products: urea - uric acid - ammonia - phosphate - maintains homeostasis: including body fluid volume (water reabsorption) and solute composition (mineral balance - nutrient reabsorption) - controls *plasma* pH: antiport of Na/K and pr
Vitamin K - b12 - thiamin - riboflavin
Which is why lactase - maltase - dextrinase - sucrase are on brush border

47. Thus inhibiting parietal cells could do What to blood pH
Smooth ER
Pancreatic duct (made of acinar cells?)
Serous membrane (slick - reducing friction) that forms lining of the coelom --> secretes lubricating fluid
Lower blood pH

48. What hormones affect the stomach?
Salivary amylase (weak); sm intest amylase (breaks down large polysaccharides)
Facilitated diffusion: no symport w/ secondary transport
Adrenocorticotropin; stims adrenal cortex release of glucocorticoids (eg cortisol - a steroid) stress hormones via second messenger system using cAMP
Hormones --->stimulate exocrine glands - acetylcholine (increases all secretion of gastric pits) - gastrin (from G cells) - histamine (increases HCl secretion of parietals) ...Ach increases all secretions; gastrin increases gastric acid (parietal cel

49. What force is acting upon chyme to move it forward down sm intestine
Peristalsis (esophagus) and segmentation (bi - directional=mixing)
Glucose and ketone bodies (not from glycogen stores)
Trypsin(- ogen; activates other panc enzymes after it is activated by enterokinase of sm intest); chymotrypsin - amylase - lipase
Carry signals to musc OR Gland

50. Where is bile produced
***starting with adipose tiss: FFAs are transported in the blood by albumin (major component of blood plasma); one albumin typically carries three fatty acid molecules but can hold up to 30 FAs
Trypsinogen is activated by enterokinase in the brush border; in turn - it activates other enzymes
In liver (RBC recycling of heme); stored in gall bladder; released via cystic duct to common bile duct (shared w/liver); common bile duct joins up with panc duct...everything feeds into the sm intest at the ampulla of vater**
Abdominal cavity - which is coated in serous fluid

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