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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the lateral side of the dorsum of the foot?






2. Type IV hypersensitivity is i...






3. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






4. what mediates the type II hypersensitivity? What are the two different methods?






5. What is Aldesleukin? What is it used for






6. which interleukin receptor is required for NK development? activation?






7. What are four results of a splenectomy?






8. Leukocyte adhesion defect presents with...






9. What is the cause of thymic aplasia? What is its presentation? What are the labs?






10. What are the mediators that mast cells release?






11. What portion of the lymph node is not well developed in DiGeorge Syndrome?






12. What are the autoantibodies for polymyositis and dermatomyositis?






13. What type of fenestrations are found in the red pulp of the spleen?






14. Describe the capsular structure of a lymph node; What are the functions of the LN?






15. What lymph node drains the rectum (above the pectinate line)?






16. What is thrombopoietin used for?






17. The MALT/GALT are not...






18. What does IL 2 do?






19. What is the common variable immunodeficiency ? How is it different from Brutons?






20. Which antibodies can be multimeric?






21. Which MHC presents intracellular peptides? how so?






22. which cells have more complete tolerance - B or T cells?






23. What does interferon gamma do? What two type of cells does it attack mostly?






24. What are the PALS?






25. For which toxins are preformed antibodies (passive) given?






26. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






27. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






28. What is the main function of IL 12? other than macrophages who else can release IL 12?






29. What is recomb gamma interferon used for?






30. The two heavy chains of an antibody contribute to the...






31. What cytokines to Th2 secrete?






32. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






33. What are the autoantibodies for hashimotos?






34. What happens in a deficiency of C3?






35. What lymph node drains the stomach?






36. What is the white pulp of the spleen?






37. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






38. What is recomb alpha interferon used for?






39. How is sirolimus different from tacrolimus?






40. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






41. What are the main Cell surface proteins on T cells?






42. What are the autoantibodies for pernicious anemia?






43. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






44. What is the toxicity of muromonab?






45. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






46. What lymph node drains the sigmoid colon?






47. which B and T cell disorder presents with specifically low IgM?






48. what characterizes an arthus reaction?






49. What kinds of receptors activate innate immunity?






50. Which disease is associated with DR7?