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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are target cells?






2. What does interferon gamma do to be antiviral?






3. What is a factor that is a predictor for a bad transplantation?






4. What is recomb beta interferon used for?






5. can igG cross the placenta?






6. The MALT/GALT are not...






7. What is the receptor for EBV? On what cells is that located?






8. What is the marginal zone of the spleen? what happens there?






9. Which MHC presents intracellular peptides? how so?






10. What is the pathogenesis of a hypersensitivity reaction?






11. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






12. What is the common variable immunodeficiency ? How is it different from Brutons?






13. IgM can fix complement but...






14. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






15. The ______ in the BM are DN - the DP are in the cortex of thymus






16. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






17. How is the thymus organized? what happens in each section?






18. How fast does it occur?






19. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






20. where are complements produced?






21. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






22. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






23. For which toxins are preformed antibodies (passive) given?






24. T/F B cells do not require a second signal






25. What happens in a secondary follicle?






26. What are the two signals required for Th1 cells? what happens after then activated?






27. What is anergy? why does this occur?






28. Which diseases are associated with DR4?






29. What is the presentation of common variable immunodef? and What are the labs?






30. What is the defect in hyper IgM syndrome? What are the lab results?






31. hat is the presentation of Jobs syndrome or Hyper IgE?






32. What is the autoantibody for SLE that is nonspecific? Specific?






33. What is oprelevkin? and What is it used for?






34. Other than stimulating fever - what else does IL 6 do?






35. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






36. Give three examples of bacteria that use antigenic variation and how.






37. What are the function of B cells?






38. What does IgA pick up from epithelial cells before being secreted?






39. what mediates the type II hypersensitivity? What are the two different methods?






40. What are the three types of lymphocytes?






41. What does Interferon alpha and beta do? how?






42. What type of fenestrations are found in the red pulp of the spleen?






43. What is digoxin immune Fab used for?






44. So antibodies are the effectors for the humoral response. List some of their functions.






45. What is the general structure of an Ab?






46. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






47. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






48. What are the autoantibodies for pemphigus bulgaris?






49. What are the main Cell surface proteins on T cells?






50. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?