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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the main symptoms of T cell immunodeficiencies?






2. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






3. What is the pathology in hyperacute transplant rejection?






4. What is the main function of TNF alpha? How does it do this?






5. What is the general structure of an Ab?






6. What is hereditary angioedema? What are the C3 levels?






7. What type of side chains are found on Fc region of an antibody?






8. hat is the presentation of Jobs syndrome or Hyper IgE?






9. IgM can exist as a _______ also






10. How is i Th1 helper cell inhibited?






11. What lymph node drains the thigh?






12. what cell surface proteins are on all APCs?






13. What cytokines are released by Th1 cells?






14. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






15. What are the main Cell surface proteins on T cells?






16. What is the white pulp of the spleen?






17. What does IL 10 do? who is secreted by?






18. What is the clinical use for azathioprine?






19. What is digoxin immune Fab used for?






20. What is the presentation of Brutons agammaglobulinemia?






21. What cytokines to Th2 secrete?






22. What lymph node drains the lateral side of the dorsum of the foot?






23. What lymph node drains the duodenum - jejunum?






24. What is the pathogenesis of a hypersensitivity reaction?






25. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






26. What are the major functions of Antibodies?






27. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






28. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






29. what mediates the type II hypersensitivity? What are the two different methods?






30. What are the autoantibodies for polymyositis and dermatomyositis?






31. Which antibody mediates immunity to worms? how?






32. What is filgrastim and sargramostim? and What is it used for?






33. What is colostrum?






34. IgE has the ___________ in the serum






35. What are the autoantibodies for wegeners granulomatosis?






36. What is serum sickness? give an example.






37. Which helper T cells' development is induced by IL 4? IL 12?






38. What are the two signals to kill for NK cells?






39. which interleukin receptor is required for NK development? activation?






40. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






41. Describe the Mannose Lectin pathway






42. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






43. What are the main symptoms of B cell immunodeficiencies?






44. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






45. How do you test for chronic granulomatous disease?






46. What type of fenestrations are found in the red pulp of the spleen?






47. Describe complement dependent Type II hypersensitivity. Give an example.






48. The pathogenesis of contact dermatitis is ________ hypersensitivity






49. what will NK cells do to cells covered in IgG Ab? why?






50. What does granulysin do?