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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what cytokine does basophils secrete?






2. Which disease is associated withB B27?






3. Name 5 ways Antibody diversity is generated?






4. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






5. For which toxins are preformed antibodies (passive) given?






6. Which helper T cells' development is induced by IL 4? IL 12?






7. What does interferon gamma do? What two type of cells does it attack mostly?






8. are Th cells involved in trapping of antigens of endotoxin/LPS?






9. What lymph node drains the thigh?






10. What are target cells?






11. What does it mean if there are igM in the serum at birth?






12. Name the three opsonins






13. What are the autoantibodies for Celiac disease?






14. How is the thymus organized? what happens in each section?






15. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






16. What are the autoantibodies for sjorgens syndrome?






17. What lymph node drains the upper limb?






18. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






19. What are the symptoms of serum sickness?






20. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






21. Name two endogenous pyrogens






22. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






23. What is the clinical use for sirolimus? what should you combine it with?






24. What are C1 - C2 - C3 - C4 important for?






25. what cell surface proteins are on all APCs?






26. which antibodies can bind complement?






27. In thymic development - What is the positive selection? negative selections?






28. Complements are...






29. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






30. what bacteria are a splenectomy patient most susceptible to? why?






31. IgM can fix complement but...






32. What is the treatment of acute transplant rejection?






33. What is the late phase reaction of anaphylaxis allergy? what mediates it?






34. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






35. The ______ in the BM are DN - the DP are in the cortex of thymus






36. The secondary follicles have __________; primary follicles are dense






37. What are the PALS?






38. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






39. What cytokines to Th2 secrete?






40. What is serum sickness? give an example.






41. Which antibodies can be multimeric?






42. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






43. What is recomb gamma interferon used for?






44. What does IL 10 do? who is secreted by?






45. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






46. What is the pathology in hyperacute transplant rejection?






47. What is the pathogenesis of acute transplant rejection? When does it occur?






48. when can graft versus host disease? What is the result?






49. The idiotype; the Fc portion determines the...






50. What is the marginal zone of the spleen? what happens there?