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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are superantigens? give two examples.






2. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






3. What is Aldesleukin? What is it used for






4. Which diseases are associated with DR4?






5. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






6. What does CD16 on NK cells do?






7. What are MHC's necessary for? By themselves?






8. Leukocyte adhesion defect presents with...






9. What is recomb alpha interferon used for?






10. How is sirolimus different from tacrolimus?






11. What happens in a deficiency of C3?






12. describe the classic complement pathway.






13. What is thrombopoietin used for?






14. Which is the main antibody that provides passive immunity to infants?






15. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






16. How does the alternative pathway lead to MAC activation?






17. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






18. How does igA cross the epithelium?






19. What is the most common selective Ig deficiency? What is the presentation?






20. What is the cause of thymic aplasia? What is its presentation? What are the labs?






21. How is the antigen loaded onto a MHC II?






22. What is the main function of IL 12? other than macrophages who else can release IL 12?






23. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






24. What are four results of a splenectomy?






25. What are target cells?






26. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






27. Which is the most abundant antibody in blood?






28. which antibody is involved in the primary response or immediate response to an antigen?






29. give an example of how influenza does a major antigenic shift.






30. What is the receptor for EBV? On what cells is that located?






31. What is the marginal zone of the spleen? what happens there?






32. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






33. What are the three types of APCs?






34. What are the main Cell surface proteins on T cells?






35. What is the pathogenesis of a hypersensitivity reaction?






36. IgM can exist as a _______ also






37. Which diseases are associated with DR5?






38. What are the autoantibodies for autoimmune hepatitis?






39. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






40. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






41. Describe complement dependent Type II hypersensitivity. Give an example.






42. What lymph node drains the upper limb?






43. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






44. What is the toxicity of azathioprine?






45. How fast does it occur?






46. What is the presentation of common variable immunodef? and What are the labs?






47. which cells have more complete tolerance - B or T cells?






48. What is the pathology seen in chronic transplant rejection?






49. What does IgA pick up from epithelial cells before being secreted?






50. What links the adaptive and innate immunity?






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