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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






2. What is the presentation of hyperIgM syndrome?






3. Name 5 ways Antibody diversity is generated?






4. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






5. What is the toxicity of muromonab?






6. What is chronic mucocutaneous candidiasis d/t?






7. What are the autoantibodies for pemphigus bulgaris?






8. What happens in a secondary follicle?






9. What are the cell surface proteins for Macrophages? which two are for opsonins?






10. What are the function of B cells?






11. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






12. What is hereditary angioedema? What are the C3 levels?






13. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






14. Monomer in circulation - ___ when secreted






15. Give three examples of bacteria that use antigenic variation and how.






16. IgM can fix complement but...






17. What are the autoantibodies for Celiac disease?






18. what will NK cells do to cells covered in IgG Ab? why?






19. what characterizes an arthus reaction?






20. What is an example of a parasite showing antigenic variation?






21. Which diseases are associated with DR2?






22. What is the defect in hyper IgM syndrome? What are the lab results?






23. What is serum sickness? give an example.






24. where are complements produced?






25. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






26. What is the presentation of scid? treatment?






27. describe the pathogenesis of delayed type IV hypersensitivity






28. What are the autoantibodies for myasthenia gravis?






29. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






30. What lymph node drains the thigh?






31. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






32. describe the classic complement pathway.






33. What are the autoantibodies for autoimmune hepatitis?






34. What lymph node drains the testes?






35. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






36. What is Aldesleukin? What is it used for






37. What is the presentation of common variable immunodef? and What are the labs?






38. other than C3a - what other complement acts as an anaphyloxin?






39. Which disease is associated with B8?






40. What lymph node drains the lateral side of the dorsum of the foot?






41. What lymph node drains the duodenum - jejunum?






42. IgG...






43. what cytokine does basophils secrete?






44. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






45. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






46. How does the alternative pathway lead to MAC activation?






47. What are the three types of lymphocytes?






48. What is a type I hypersensitivity reaction? What is atopic?






49. Give an example of someone who could get hyperacute transplant rejection.






50. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?