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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the pathogenesis of HyperIgE syndrome? What are the labs?






2. What lymph node drains the lateral side of the dorsum of the foot?






3. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






4. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






5. What cytokines to Th2 secrete?






6. To what portion of the Antibody do the complements bind?






7. What are the two signals required for T cells? what happens after?






8. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






9. What are MHC's necessary for? By themselves?






10. which interleukin receptor is required for NK development? activation?






11. What is serum sickness? give an example.






12. What is the toxicity of muromonab?






13. What lymph node drains the rectum (above the pectinate line)?






14. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






15. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






16. What links the adaptive and innate immunity?






17. What is muromonab - CD3 (OKT3)






18. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






19. ________ regulate the cell mediated response.






20. what will NK cells do to cells covered in IgG Ab? why?






21. What are the autoantibodies for sjorgens syndrome?






22. Which antibody mediates immunity to worms? how?






23. describe the classic complement pathway.






24. what results in symptoms of shock in an acute hemolytic transfusion reaction?






25. What are the autoantibodies for hashimotos?






26. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






27. what bacteria are a splenectomy patient most susceptible to? why?






28. Only the _______ contribute to the Fc region






29. What is the most common example of passive immunity?






30. Leukocyte adhesion defect presents with...






31. Which MHC presents intracellular peptides? how so?






32. What does IL 2 do?






33. where are complements produced?






34. Type IV hypersensitivity is i...






35. What portion of the lymph node is not well developed in DiGeorge Syndrome?






36. Which is the main antibody in the delayed or secondary response to an antigen?






37. which of the transplant rejections is antibody mediated? why does it occur?






38. What is the main function of interferons?






39. What are superantigens? give two examples.






40. what cell surface proteins are on all APCs?






41. What is the toxicity of azathioprine?






42. What does granulysin do?






43. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






44. Which disease is associated with DR3?






45. Which is the most abundant antibody in blood?






46. The Fc region is found on the...






47. which B and T cell disorder presents with specifically low IgM?






48. where do somatic hypermutation and class switching occur?






49. are Th cells involved in trapping of antigens of endotoxin/LPS?






50. What does Interferon alpha and beta do? how?