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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the presentation of scid? treatment?






2. What is the common variable immunodeficiency ? How is it different from Brutons?






3. What are the T cell functions?






4. What are the main cell surface proteins on B cells?






5. Describe complement dependent Type II hypersensitivity. Give an example.






6. What is anergy? why does this occur?






7. What cytokines are released by Th1 cells?






8. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






9. What are the main Cell surface proteins on T cells?






10. What is a type I hypersensitivity reaction? What is atopic?






11. IgE has the ___________ in the serum






12. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






13. What is the main function of interferons?






14. For which toxins are preformed antibodies (passive) given?






15. What are the autoantibodies for drug induced lupus?






16. What does IL 5 do?






17. The lymphocytes are ________ origin






18. Other than stimulating fever - what else does IL 6 do?






19. can igG cross the placenta?






20. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






21. What happens in a deficiency of C3?






22. What is the main cytokine released by T cells? What does it do






23. What happens in a secondary follicle?






24. Monomer in circulation - ___ when secreted






25. what bacteria are a splenectomy patient most susceptible to? why?






26. What cytokines to Th2 secrete?






27. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






28. What is a factor that is a predictor for a bad transplantation?






29. What are some sinopulmonary infections?






30. what ensure that a memory response is generated?






31. what happens in a deficiency of C1 esterase inhibitor? DAF?






32. What are the two signals required for B cell class switching? Which is the second signal?






33. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






34. What are the cell surface proteins on NK cells?






35. So antibodies are the effectors for the humoral response. List some of their functions.






36. What does granulysin do?






37. What does CD16 on NK cells do?






38. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






39. What is the clinical use of Muromonab?






40. Give three examples of bacteria that use antigenic variation and how.






41. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






42. What is the marginal zone of the spleen? what happens there?






43. How is the thymus organized? what happens in each section?






44. How does igA cross the epithelium?






45. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






46. How do you test for type III hypersensitivity?






47. What is the clinical use for sirolimus? what should you combine it with?






48. What are four results of a splenectomy?






49. Which cytokines do Th2 release and For what?






50. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?