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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for wegeners granulomatosis?






2. How fast does it occur?






3. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






4. What is the autoantibody for SLE that is nonspecific? Specific?






5. What is the general structure of an Ab?






6. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






7. IgM can fix complement but...






8. What lymph node drains the thigh?






9. Which helper T cells' development is induced by IL 4? IL 12?






10. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






11. What is the toxicity of azathioprine?






12. What are the autoantibodies for autoimmune hepatitis?






13. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






14. What are the symptoms of serum sickness?






15. What is the presentation of Brutons agammaglobulinemia?






16. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






17. What are four results of a splenectomy?






18. What are the main cell surface proteins on B cells?






19. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






20. What lymph node drains the upper limb?






21. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






22. How do you test for chronic granulomatous disease?






23. What is the main cytokine that activates eosinophils?






24. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






25. What is the defect in hyper IgM syndrome? What are the lab results?






26. What are the main symptoms of B cell immunodeficiencies?






27. What is the main function of interferons?






28. What happens in a deficiency of C3?






29. The lymphocytes are ________ origin






30. What are the autoantibodies for goodpastures syndrome?






31. What is filgrastim and sargramostim? and What is it used for?






32. Which are the only two antiinflammatory cytokines?






33. What happens in a secondary follicle?






34. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






35. Monomer in circulation - ___ when secreted






36. What are superantigens? give two examples.






37. Type Iv hypersensitivity is...






38. What is the presentation of hyperIgM syndrome?






39. What is the white pulp of the spleen?






40. which interleukin receptor is required for NK development? activation?






41. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






42. which B and T cell disorder presents with specifically low IgM?






43. What does Interferon alpha and beta do? how?






44. What is the most common example of passive immunity?






45. What is the presentation of common variable immunodef? and What are the labs?






46. What is the clinical use of Muromonab?






47. Which is the main antibody in the delayed or secondary response to an antigen?






48. What are the autoantibodies for other vasculitides?






49. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






50. What are the cell surface proteins on NK cells?







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