Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which of the transplant rejections is antibody mediated? why does it occur?






2. What is the pathology of acute transplant rejection? is it reversible?






3. What are the T cell functions?






4. What are the autoantibodies for pernicious anemia?






5. What are the autoantibodies for Celiac disease?






6. What does granulysin do?






7. Which diseases are associated with DR5?






8. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






9. What is filgrastim and sargramostim? and What is it used for?






10. What are the main cell surface proteins on B cells?






11. Describe the Mannose Lectin pathway






12. What are the mediators that mast cells release?






13. How do you test for type III hypersensitivity?






14. Leukocyte adhesion defect presents with...






15. What does IL 5 do?






16. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






17. The ______ in the BM are DN - the DP are in the cortex of thymus






18. What is the general structure of an Ab?






19. What is the main function of IL 12? other than macrophages who else can release IL 12?






20. What is muromonab - CD3 (OKT3)






21. IgG...






22. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






23. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






24. What is passive immunity?






25. describe the classic complement pathway.






26. What lymph node drains the rectum (above the pectinate line)?






27. What lymph node drains the anal canal (below the pectinate line)?






28. Which are the only two antiinflammatory cytokines?






29. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






30. What are some catalase positive organisms?






31. Give three examples of bacteria that use antigenic variation and how.






32. What kinds of receptors activate innate immunity?






33. What is hereditary angioedema? What are the C3 levels?






34. What is the toxicity of muromonab?






35. What is the clinical use for azathioprine?






36. What are the autoantibodies for polymyositis and dermatomyositis?






37. What lymph node drains the sigmoid colon?






38. what results in symptoms of shock in an acute hemolytic transfusion reaction?






39. To what portion of the Antibody do the complements bind?






40. What are the main symptoms of B cell immunodeficiencies?






41. What does it mean if there are igM in the serum at birth?






42. What is the main cytokine that activates eosinophils?






43. Complements are...






44. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






45. How is i Th1 helper cell inhibited?






46. The two heavy chains of an antibody contribute to the...






47. What links the adaptive and innate immunity?






48. which type of immunity is slow but long lasting? as opposed to...






49. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






50. What cytokines to Th2 secrete?