Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the pathology seen in chronic transplant rejection?






2. What lymph node drains the upper limb?






3. Which antibody mediates immunity to worms? how?






4. what characterizes an arthus reaction?






5. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






6. The two heavy chains of an antibody contribute to the...






7. Which are the only two antiinflammatory cytokines?






8. are Th cells involved in trapping of antigens of endotoxin/LPS?






9. What are howell jolly bodies?






10. Which disease is associated with DR7?






11. What do multimeric antibodies require for assembly?






12. Name 5 ways Antibody diversity is generated?






13. What can cause a lymph node enlargement?






14. Which cytokines do Th2 release and For what?






15. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






16. What lymph node drains the duodenum - jejunum?






17. What are the two signals required for Th1 cells? what happens after then activated?






18. What happens in a secondary follicle?






19. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






20. Describe the Mannose Lectin pathway






21. __________ are a part of the innate system.






22. What are the two signals required for T cells? what happens after?






23. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






24. What does Interferon alpha and beta do? how?






25. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






26. What are MHC's necessary for? By themselves?






27. What are the autoantibodies for Celiac disease?






28. which of the hypersensitivity reactions is not Ab mediated?






29. which antibody is involved in the primary response or immediate response to an antigen?






30. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






31. How does the alternative pathway lead to MAC activation?






32. What are the autoantibodies for systemic sclerosis?






33. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






34. What are the autoantibodies for drug induced lupus?






35. What is the pathogenesis of a hypersensitivity reaction?






36. The secondary follicles have __________; primary follicles are dense






37. what mediates the type II hypersensitivity? What are the two different methods?






38. What is epo used for?






39. which type of immunity is slow but long lasting? as opposed to...






40. What is passive immunity?






41. What is chronic mucocutaneous candidiasis d/t?






42. other than mediating shock - what else does TNF alpha do? who releases it mainly?






43. Which type of selection of thymic development provides central tolerance?






44. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






45. Which disease is associated withB B27?






46. How is the antigen loaded onto a MHC II?






47. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






48. What are the autoantibodies for myasthenia gravis?






49. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






50. What is the pathogenesis of a candida skin test?