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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which disease is associated with DR7?






2. What do multimeric antibodies require for assembly?






3. What is three common causes of severe combined immunodef? What is the result of all three?






4. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






5. What are the autoantibodies for primary biliary cirrhosis?






6. What lymph node drains the sigmoid colon?






7. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






8. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






9. which cytokine inhibits TH2 cells? secreted by who?






10. What is Aldesleukin? What is it used for






11. What are the autoantibodies for Celiac disease?






12. What are the cell surface proteins for Macrophages? which two are for opsonins?






13. What is colostrum?






14. Leukocyte adhesion defect presents with...






15. What is the clinical use of Muromonab?






16. can igG cross the placenta?






17. What does interferon gamma do? What two type of cells does it attack mostly?






18. describe the pathogenesis of delayed type IV hypersensitivity






19. What is the defect in hyper IgM syndrome? What are the lab results?






20. What does IL 4 do?






21. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






22. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






23. Which diseases are associated with DR4?






24. what secretes IL 4?






25. What are the autoantibodies for other vasculitides?






26. which of the hypersensitivity reactions is not Ab mediated?






27. What is filgrastim and sargramostim? and What is it used for?






28. What are the autoantibodies for goodpastures syndrome?






29. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






30. __________ are a part of the innate system.






31. What is the main cytokine that activates eosinophils?






32. What is the pathogenesis of a hypersensitivity reaction?






33. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






34. What are the mediators that mast cells release?






35. Which disease is associated with HLA A3?






36. What do mature naive B lymphocytes express?






37. what prevents NK cells from killing normal cells if their default is to kill?






38. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






39. What does granulysin do?






40. what cytokine does basophils secrete?






41. What are the major functions of Antibodies?






42. What is the most common selective Ig deficiency? What is the presentation?






43. Which antibodies can be multimeric?






44. Which cytokines do Th2 release and For what?






45. What lymph node drains the testes?






46. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






47. What are the autoantibodies for type I diabetes mellitus?






48. What is immune complex disease? give an example.






49. What is the late phase reaction of anaphylaxis allergy? what mediates it?






50. How fast does it occur?