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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which interleukin receptor is required for NK development? activation?

2. What is the treatment of acute transplant rejection?

3. what happens in a deficiency of C1 esterase inhibitor? DAF?

4. which of the transplant rejections is antibody mediated? why does it occur?

5. ________ regulate the cell mediated response.

6. Name two endogenous pyrogens

7. What are the main Cell surface proteins on T cells?

8. describe the classic complement pathway.

9. What are the autoantibodies for type I diabetes mellitus?

10. What is hereditary angioedema? What are the C3 levels?

11. What lymph node drains the scrotum?

12. Which disease is associated with DR7?

13. What is passive immunity?

14. IgE has the ___________ in the serum

15. other than mediating shock - what else does TNF alpha do? who releases it mainly?

16. What are the mediators that mast cells release?

17. Give three examples of bacteria that use antigenic variation and how.

18. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?

19. What are howell jolly bodies?

20. Name the three opsonins

21. What is epo used for?

22. How is the thymus organized? what happens in each section?

23. What is thrombopoietin used for?

24. What are four results of a splenectomy?

25. Describe complement dependent Type II hypersensitivity. Give an example.

26. What is recomb gamma interferon used for?

27. what will NK cells do to cells covered in IgG Ab? why?

28. What does Interferon alpha and beta do? how?

29. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?

30. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example

31. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?

32. What are some sinopulmonary infections?

33. What is the white pulp of the spleen?

34. is IgM an opsonizer?

35. Which disease is associated with HLA A3?

36. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?

37. where are complements produced?

38. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?

39. Which disease is associated with DR3?

40. What are superantigens? give two examples.

41. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?

42. Which are the only two antiinflammatory cytokines?

43. What is the presentation of scid? treatment?

44. How is the antigen loaded onto a MHC II?

45. Which is the main antibody that provides passive immunity to infants?

46. How do you test for chronic granulomatous disease?

47. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?

48. What is the clinical use for azathioprine?

49. To what portion of the Antibody do the complements bind?

50. What is the main cytokine that activates eosinophils?