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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the cell surface proteins on NK cells?






2. Only the _______ contribute to the Fc region






3. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






4. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






5. What are the cell surface proteins for Macrophages? which two are for opsonins?






6. What is filgrastim and sargramostim? and What is it used for?






7. what cytokine does basophils secrete?






8. What are the main cell surface proteins on B cells?






9. What is the main function of IL 12? other than macrophages who else can release IL 12?






10. Which is the main antibody in the delayed or secondary response to an antigen?






11. What are the autoantibodies for Celiac disease?






12. What is the presentation of scid? treatment?






13. Which helper T cells' development is induced by IL 4? IL 12?






14. The ______ in the BM are DN - the DP are in the cortex of thymus






15. What is the presentation of hyperIgM syndrome?






16. What links the adaptive and innate immunity?






17. What cytokines are released by Th1 cells?






18. What type of fenestrations are found in the red pulp of the spleen?






19. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






20. What are the function of B cells?






21. Type Iv hypersensitivity is...






22. What does granzyme do? who secretes it?






23. when can graft versus host disease? What is the result?






24. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






25. What is the treatment of acute transplant rejection?






26. What is anergy? why does this occur?






27. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






28. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






29. What does interferon gamma do to be antiviral?






30. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






31. What are the autoantibodies for drug induced lupus?






32. What are the two signals required for B cell class switching? Which is the second signal?






33. How fast does it occur?






34. What happens in a deficiency of C3?






35. What lymph node drains the breast?






36. which type of immunity is slow but long lasting? as opposed to...






37. How do you test for type III hypersensitivity?






38. The secondary follicles have __________; primary follicles are dense






39. describe the pathogenesis of delayed type IV hypersensitivity






40. Leukocyte adhesion defect presents with...






41. What are the three types of APCs?






42. What are the autoantibodies for graves?






43. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






44. give an example of how influenza does a major antigenic shift.






45. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






46. What are the main symptoms of B cell immunodeficiencies?






47. What are superantigens? give two examples.






48. What bugs can actually infect the lymph node itself?






49. What does granulysin do?






50. what secretes IL 4?