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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






2. What does interferon gamma do? What two type of cells does it attack mostly?






3. What are the autoantibodies for hashimotos?






4. What type of fenestrations are found in the red pulp of the spleen?






5. which cytokine inhibits TH2 cells? secreted by who?






6. What lymph node drains the lateral side of the dorsum of the foot?






7. Complements are...






8. what results in symptoms of shock in an acute hemolytic transfusion reaction?






9. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






10. What lymph node drains the testes?






11. What is the presentation of scid? treatment?






12. To what portion of the Antibody do the complements bind?






13. What is the pathology in hyperacute transplant rejection?






14. The ______ in the BM are DN - the DP are in the cortex of thymus






15. What is the main function of IL 8?






16. What is the most common selective Ig deficiency? What is the presentation?






17. where do somatic hypermutation and class switching occur?






18. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






19. which cells have more complete tolerance - B or T cells?






20. What is the marginal zone of the spleen? what happens there?






21. What lymph node drains the anal canal (below the pectinate line)?






22. What is the common variable immunodeficiency ? How is it different from Brutons?






23. which antibody is involved in the primary response or immediate response to an antigen?






24. What is the late phase reaction of anaphylaxis allergy? what mediates it?






25. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






26. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






27. can igG cross the placenta?






28. What are the autoantibodies for myasthenia gravis?






29. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






30. what cell surface marker is used for NK cells as it is unique to them?






31. What are the main symptoms of T cell immunodeficiencies?






32. What are the two signals to kill for NK cells?






33. What is the autoantibody for SLE that is nonspecific? Specific?






34. What are the three types of lymphocytes?






35. Which diseases are associated with DR4?






36. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






37. Which is the main antibody in the delayed or secondary response to an antigen?






38. What are howell jolly bodies?






39. What are the two signals required for T cells? what happens after?






40. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






41. The lymphocytes are ________ origin






42. which B and T cell disorder presents with specifically low IgM?






43. What are the three types of APCs?






44. What are the autoantibodies for pernicious anemia?






45. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






46. What is the pathogenesis of a hypersensitivity reaction?






47. What is serum sickness? give an example.






48. What is an example of a parasite showing antigenic variation?






49. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






50. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?







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