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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is epo used for?






2. The ______ in the BM are DN - the DP are in the cortex of thymus






3. What cytokines to Th2 secrete?






4. What is Aldesleukin? What is it used for






5. What is the presentation of scid? treatment?






6. what prevents NK cells from killing normal cells if their default is to kill?






7. What lymph node drains the scrotum?






8. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






9. What are the symptoms of serum sickness?






10. other than eat and bite RBCs what else do Macrophages of spleen do>






11. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






12. What does IL 4 do?






13. What does granzyme do? who secretes it?






14. What are the two signals required for B cell class switching? Which is the second signal?






15. What are the three types of lymphocytes?






16. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






17. What lymph node drains the sigmoid colon?






18. What lymph node drains the upper limb?






19. What cytokines are released by Th1 cells?






20. Type Iv hypersensitivity is...






21. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






22. Which MHC presents intracellular peptides? how so?






23. How does the alternative pathway lead to MAC activation?






24. What is the most common example of passive immunity?






25. Which cytokines do Th2 release and For what?






26. How is the antigen loaded onto a MHC II?






27. where are complements produced?






28. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






29. is IgM an opsonizer?






30. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






31. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






32. What is hereditary angioedema? What are the C3 levels?






33. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






34. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






35. Which is the most abundant antibody in blood?






36. The Fc region is found on the...






37. What are the autoantibodies for other vasculitides?






38. What is muromonab - CD3 (OKT3)






39. What is the pathogenesis of a candida skin test?






40. What is colostrum?






41. Which disease is associated with HLA A3?






42. What is the autoantibody for SLE that is nonspecific? Specific?






43. What happens in a deficiency of C3?






44. which cells have more complete tolerance - B or T cells?






45. The alternative pathway is the only constutively...






46. What are some catalase positive organisms?






47. where do NK cells develop?






48. What are target cells?






49. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






50. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?