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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What does interferon gamma do? What two type of cells does it attack mostly?






2. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






3. The lymphocytes are ________ origin






4. How is sirolimus different from tacrolimus?






5. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






6. What are the three types of lymphocytes?






7. What are the autoantibodies for autoimmune hepatitis?






8. What is the main cytokine released by T cells? What does it do






9. What is the clinical use of Muromonab?






10. What is recomb gamma interferon used for?






11. What does it mean if there are igM in the serum at birth?






12. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






13. Only the _______ contribute to the Fc region






14. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






15. give an example of how influenza does a major antigenic shift.






16. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






17. What are the autoantibodies for primary biliary cirrhosis?






18. From where do cytokines come from?






19. What is three common causes of severe combined immunodef? What is the result of all three?






20. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






21. IgG...






22. Type Iv hypersensitivity is...






23. Leukocyte adhesion defect presents with...






24. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






25. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






26. What is the presentation of scid? treatment?






27. What are the autoantibodies for drug induced lupus?






28. What type of fenestrations are found in the red pulp of the spleen?






29. What is the main function of interferons?






30. How does complement link innate and adaptive?






31. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






32. What are the autoantibodies for hashimotos?






33. in which immunodef order do you see a lot of pus? no pus?






34. What is the pathogenesis of a candida skin test?






35. What are the symptoms of serum sickness?






36. Which is the main antibody in the delayed or secondary response to an antigen?






37. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






38. What are the T cell functions?






39. Which is the most abundant antibody in blood?






40. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






41. What bugs can actually infect the lymph node itself?






42. What is serum sickness? give an example.






43. What is the common variable immunodeficiency ? How is it different from Brutons?






44. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






45. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






46. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






47. What lymph node drains the lateral side of the dorsum of the foot?






48. What is anergy? why does this occur?






49. which type of immunity is slow but long lasting? as opposed to...






50. How is the antigen loaded onto a MHC II?