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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for myasthenia gravis?






2. which of the transplant rejections is antibody mediated? why does it occur?






3. What are the two signals required for Th1 cells? what happens after then activated?






4. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






5. For which toxins are preformed antibodies (passive) given?






6. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






7. What is three common causes of severe combined immunodef? What is the result of all three?






8. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






9. What does IL 5 do?






10. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






11. where do NK cells develop?






12. Describe the capsular structure of a lymph node; What are the functions of the LN?






13. when can graft versus host disease? What is the result?






14. What are the autoantibodies for Mixed connective tissue disease?






15. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






16. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






17. Which diseases are associated with DR5?






18. What lymph node drains the scrotum?






19. How does igA cross the epithelium?






20. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






21. ________ regulate the cell mediated response.






22. What is the receptor for EBV? On what cells is that located?






23. other than eat and bite RBCs what else do Macrophages of spleen do>






24. From where do cytokines come from?






25. what results in symptoms of shock in an acute hemolytic transfusion reaction?






26. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






27. What are the two signals required for B cell class switching? Which is the second signal?






28. Which helper T cells' development is induced by IL 4? IL 12?






29. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






30. To what portion of the Antibody do the complements bind?






31. How do you test for type III hypersensitivity?






32. What is recomb beta interferon used for?






33. What are the T cell functions?






34. Which disease is associated with HLA A3?






35. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






36. What lymph node drains the sigmoid colon?






37. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






38. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






39. What is the general structure of an Ab?






40. How do you test for chronic granulomatous disease?






41. What are the labs in brutons agammaglobulinemia?






42. What is the pathogenesis of a candida skin test?






43. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






44. What is the mechanism for sirolimus? what else it known as?






45. Only the _______ contribute to the Fc region






46. What is recomb gamma interferon used for?






47. Which diseases are associated with DR4?






48. What does interferon gamma do to be antiviral?






49. Describe the Mannose Lectin pathway






50. Complements are...