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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the autoantibody for SLE that is nonspecific? Specific?






2. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






3. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






4. which of the transplant rejections is antibody mediated? why does it occur?






5. which of the hypersensitivity reactions is not Ab mediated?






6. what ensure that a memory response is generated?






7. where are complements produced?






8. Describe the Mannose Lectin pathway






9. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






10. What is Aldesleukin? What is it used for






11. In general What are T cells good for?






12. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






13. What is a type I hypersensitivity reaction? What is atopic?






14. To what disease do the autoantibodies to IgG (rheumatoid factor)?






15. Which helper T cells' development is induced by IL 4? IL 12?






16. What is digoxin immune Fab used for?






17. ________ regulate the cell mediated response.






18. What is the cause of thymic aplasia? What is its presentation? What are the labs?






19. Which disease is associated with DR3?






20. What lymph node drains the lateral side of the dorsum of the foot?






21. What can cause a lymph node enlargement?






22. What cytokines to Th2 secrete?






23. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






24. What lymph node drains the rectum (above the pectinate line)?






25. other than C3a - what other complement acts as an anaphyloxin?






26. Which disease is associated with HLA A3?






27. What happens in a deficiency of C3?






28. What is the treatment of acute transplant rejection?






29. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






30. Complements are...






31. What are the cell surface proteins on NK cells?






32. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






33. which type of immunity is slow but long lasting? as opposed to...






34. What are the two signals required for T cells? what happens after?






35. other than mediating shock - what else does TNF alpha do? who releases it mainly?






36. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






37. Which diseases are associated with DR2?






38. What are the autoantibodies for Mixed connective tissue disease?






39. What does CD16 on NK cells do?






40. Leukocyte adhesion defect presents with...






41. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






42. How do you test for type III hypersensitivity?






43. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






44. Which are the only two antiinflammatory cytokines?






45. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






46. How fast does it occur?






47. what mediates the type II hypersensitivity? What are the two different methods?






48. What is filgrastim and sargramostim? and What is it used for?






49. What is the most common example of passive immunity?






50. What lymph node drains the upper limb?