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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the T cell functions?






2. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






3. Which diseases are associated with DR5?






4. What are the cell surface proteins for Macrophages? which two are for opsonins?






5. can igG cross the placenta?






6. What are the main symptoms of T cell immunodeficiencies?






7. What are the autoantibodies for hashimotos?






8. IgM can fix complement but...






9. What does interferon gamma do? What two type of cells does it attack mostly?






10. what cell surface marker is used for NK cells as it is unique to them?






11. What are C1 - C2 - C3 - C4 important for?






12. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






13. other than eat and bite RBCs what else do Macrophages of spleen do>






14. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






15. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






16. IgG...






17. What is the pathology seen in chronic transplant rejection?






18. What are four results of a splenectomy?






19. What does Interferon alpha and beta do? how?






20. What are the autoantibodies for other vasculitides?






21. describe the classic complement pathway.






22. what results in symptoms of shock in an acute hemolytic transfusion reaction?






23. Leukocyte adhesion defect presents with...






24. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






25. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






26. What is an example of a parasite showing antigenic variation?






27. What is the pathogenesis of acute transplant rejection? When does it occur?






28. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






29. What does IL 2 do?






30. are Th cells involved in trapping of antigens of endotoxin/LPS?






31. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






32. What is the pathology of acute transplant rejection? is it reversible?






33. How does igA cross the epithelium?






34. How is i Th1 helper cell inhibited?






35. The lymphocytes are ________ origin






36. What are the main symptoms of B cell immunodeficiencies?






37. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






38. What is the clinical use for sirolimus? what should you combine it with?






39. what characterizes an arthus reaction?






40. Which antibodies can be multimeric?






41. What kinds of receptors activate innate immunity?






42. What do mature naive B lymphocytes express?






43. Name the three opsonins






44. How is the thymus organized? what happens in each section?






45. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






46. What lymph node drains the thigh?






47. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






48. What is the autoantibody for SLE that is nonspecific? Specific?






49. What are the autoantibodies for graves?






50. What lymph node drains the breast?







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