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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the main function of IL 8?

2. What is hereditary angioedema? What are the C3 levels?

3. What kinds of receptors activate innate immunity?

4. What does interferon gamma do to be antiviral?

5. What happens in a secondary follicle?

6. What are the main symptoms of T cell immunodeficiencies?

7. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?

8. Which disease is associated withB B27?

9. which of the hypersensitivity reactions is not Ab mediated?

10. when can graft versus host disease? What is the result?

11. Name 5 ways Antibody diversity is generated?

12. What is the autoantibody for SLE that is nonspecific? Specific?

13. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?

14. What is chronic mucocutaneous candidiasis d/t?

15. Which disease is associated with B8?

16. are Th cells involved in trapping of antigens of endotoxin/LPS?

17. What are the autoantibodies for hashimotos?

18. What is the presentation of scid? treatment?

19. What is the most common selective Ig deficiency? What is the presentation?

20. How does complement link innate and adaptive?

21. what happens in order for class switching to occur (after being activated by IL and cd40 L)?

22. What is the pathogenesis of a candida skin test?

23. can igG cross the placenta?

24. What is the presentation of Brutons agammaglobulinemia?

25. What is filgrastim and sargramostim? and What is it used for?

26. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?

27. Which diseases are associated with DR4?

28. What is the pathogenesis of HyperIgE syndrome? What are the labs?

29. What is the clinical use for sirolimus? what should you combine it with?

30. Name the three opsonins

31. What are MHC's necessary for? By themselves?

32. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?

33. Monomer in circulation - ___ when secreted

34. What are the main symptoms of B cell immunodeficiencies?

35. What does granulysin do?

36. What are the mediators that mast cells release?

37. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?

38. What is the pathogenesis of a hypersensitivity reaction?

39. How is i Th1 helper cell inhibited?

40. What is the pathology in hyperacute transplant rejection?

41. Which disease is associated with DR7?

42. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?

43. A lymph node is a ________ lymphoid organ.

44. What are target cells?

45. What does interferon gamma do? What two type of cells does it attack mostly?

46. What is the most common example of passive immunity?

47. What can cause a lymph node enlargement?

48. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?

49. What is the clinical use of Muromonab?

50. in which immunodef order do you see a lot of pus? no pus?