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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the general structure of an Ab?






2. What are the cell surface proteins on NK cells?






3. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






4. What lymph node drains the testes?






5. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






6. What does IL 5 do?






7. What are the two signals to kill for NK cells?






8. A lymph node is a ________ lymphoid organ.






9. what mediates the type II hypersensitivity? What are the two different methods?






10. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






11. Which antibodies can be multimeric?






12. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






13. What are MHC's necessary for? By themselves?






14. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






15. What is immune complex disease? give an example.






16. What does IL 2 do?






17. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






18. Only the _______ contribute to the Fc region






19. what prevents NK cells from killing normal cells if their default is to kill?






20. In general What are T cells good for?






21. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






22. give an example of how influenza does a major antigenic shift.






23. Which cytokines do Th2 release and For what?






24. What are the main symptoms of B cell immunodeficiencies?






25. What are the autoantibodies for goodpastures syndrome?






26. What are the PALS?






27. other than C3a - what other complement acts as an anaphyloxin?






28. What are the function of B cells?






29. __________ are a part of the innate system.






30. what characterizes an arthus reaction?






31. What lymph node drains the thigh?






32. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






33. what cytokine does basophils secrete?






34. Describe the Mannose Lectin pathway






35. Which diseases are associated with DR2?






36. What is the receptor for EBV? On what cells is that located?






37. The lymphocytes are ________ origin






38. What is three common causes of severe combined immunodef? What is the result of all three?






39. What is chronic mucocutaneous candidiasis d/t?






40. So antibodies are the effectors for the humoral response. List some of their functions.






41. Which HLA's are included in MHC I? MHC II?

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42. What does interferon gamma do to be antiviral?






43. What are the autoantibodies for autoimmune hepatitis?






44. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






45. What lymph node drains the rectum (above the pectinate line)?






46. What is the clinical use for sirolimus? what should you combine it with?






47. What is a factor that is a predictor for a bad transplantation?






48. What lymph node drains the sigmoid colon?






49. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






50. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?