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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for wegeners granulomatosis?






2. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






3. What are the autoantibodies for sjorgens syndrome?






4. What does IL 5 do?






5. where do NK cells develop?






6. What is digoxin immune Fab used for?






7. What are four results of a splenectomy?






8. The MALT/GALT are not...






9. Give three examples of bacteria that use antigenic variation and how.






10. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






11. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






12. which of the hypersensitivity reactions is not Ab mediated?






13. What are the two signals required for Th1 cells? what happens after then activated?






14. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






15. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






16. The secondary follicles have __________; primary follicles are dense






17. What can cause a lymph node enlargement?






18. What is colostrum?






19. What are the autoantibodies for primary biliary cirrhosis?






20. What are the autoantibodies for type I diabetes mellitus?






21. What are the autoantibodies for graves?






22. What is the pathogenesis of acute transplant rejection? When does it occur?






23. What is the toxicity of muromonab?






24. What is Aldesleukin? What is it used for






25. What lymph node drains the upper limb?






26. What is the clinical use of Muromonab?






27. IgG...






28. in which immunodef order do you see a lot of pus? no pus?






29. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






30. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






31. What are the cell surface proteins on NK cells?






32. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






33. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






34. What are target cells?






35. Which type of selection of thymic development provides central tolerance?






36. What is muromonab - CD3 (OKT3)






37. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






38. What cytokines are released by Th1 cells?






39. What is the pathogenesis of HyperIgE syndrome? What are the labs?






40. From where do cytokines come from?






41. Which disease is associated with HLA A3?






42. what prevents NK cells from killing normal cells if their default is to kill?






43. A lymph node is a ________ lymphoid organ.






44. Name two endogenous pyrogens






45. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






46. which antibody is involved in the primary response or immediate response to an antigen?






47. What portion of the lymph node is not well developed in DiGeorge Syndrome?






48. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






49. What is the main cytokine that activates eosinophils?






50. what results in symptoms of shock in an acute hemolytic transfusion reaction?






Can you answer 50 questions in 15 minutes?



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