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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How is the thymus organized? what happens in each section?

2. What is the white pulp of the spleen?

3. Leukocyte adhesion defect presents with...

4. what will NK cells do to cells covered in IgG Ab? why?

5. What are the autoantibodies for systemic sclerosis?

6. which antibodies prevent antigens from binding mucosal surfaces?

7. Which is the most abundant antibody in blood?

8. What does IL 10 do? who is secreted by?

9. What is the pathogenesis of HyperIgE syndrome? What are the labs?

10. Complements are...

11. which of the transplant rejections is antibody mediated? why does it occur?

12. What are the autoantibodies for myasthenia gravis?

13. What is three common causes of severe combined immunodef? What is the result of all three?

14. What portion of the lymph node is not well developed in DiGeorge Syndrome?

15. What type of fenestrations are found in the red pulp of the spleen?

16. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.

17. Which antibody mediates immunity to worms? how?

18. What is the clinical use for azathioprine?

19. What is the main function of IL 12? other than macrophages who else can release IL 12?

20. What is serum sickness? give an example.

21. What is the presentation of scid? treatment?

22. What is filgrastim and sargramostim? and What is it used for?

23. Which antibodies can be multimeric?

24. What does interferon gamma do? What two type of cells does it attack mostly?

25. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example

26. what cytokine does basophils secrete?

27. other than mediating shock - what else does TNF alpha do? who releases it mainly?

28. What are the T cell functions?

29. What is the late phase reaction of anaphylaxis allergy? what mediates it?

30. Type IV hypersensitivity is i...

31. What is immune complex disease? give an example.

32. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?

33. What is the autoantibody for SLE that is nonspecific? Specific?

34. Which disease is associated with HLA A3?

35. What cytokines to Th2 secrete?

36. What are the three types of APCs?

37. What does granzyme do? who secretes it?

38. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?

39. How is the antigen loaded onto a MHC II?

40. where do NK cells develop?

41. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?

42. What lymph node drains the anal canal (below the pectinate line)?

43. Describe complement dependent Type II hypersensitivity. Give an example.

44. What are the cell surface proteins for Macrophages? which two are for opsonins?

45. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?

46. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response

47. What are superantigens? give two examples.

48. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?

49. What is anergy? why does this occur?

50. What is the toxicity of azathioprine?