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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the testes?






2. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






3. What does CD16 on NK cells do?






4. What happens in a deficiency of C3?






5. What is the clinical use for azathioprine?






6. So antibodies are the effectors for the humoral response. List some of their functions.






7. when can graft versus host disease? What is the result?






8. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






9. To what portion of the Antibody do the complements bind?






10. which antibody activate mast cells - basophils - and eosinophils?






11. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






12. What are the autoantibodies for systemic sclerosis?






13. Which diseases are associated with DR5?






14. other than C3a - what other complement acts as an anaphyloxin?






15. other than eat and bite RBCs what else do Macrophages of spleen do>






16. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






17. What are the two signals required for B cell class switching? Which is the second signal?






18. What are the main symptoms of T cell immunodeficiencies?






19. What lymph node drains the sigmoid colon?






20. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






21. What lymph node drains the rectum (above the pectinate line)?






22. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






23. which B and T cell disorder presents with specifically low IgM?






24. What kinds of receptors activate innate immunity?






25. which of the transplant rejections is antibody mediated? why does it occur?






26. What are the autoantibodies for hashimotos?






27. Only the _______ contribute to the Fc region






28. What lymph node drains the duodenum - jejunum?






29. What is a factor that is a predictor for a bad transplantation?






30. What is the autoantibody for SLE that is nonspecific? Specific?






31. what cytokine does basophils secrete?






32. What is the main function of IL 8?






33. What does IL 5 do?






34. What is digoxin immune Fab used for?






35. IgE has the ___________ in the serum






36. What is oprelevkin? and What is it used for?






37. What is the pathology of acute transplant rejection? is it reversible?






38. What are the autoantibodies for polymyositis and dermatomyositis?






39. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






40. In general What are T cells good for?






41. What lymph node drains the anal canal (below the pectinate line)?






42. are Th cells involved in trapping of antigens of endotoxin/LPS?






43. What is the mechanism for sirolimus? what else it known as?






44. What are the three types of lymphocytes?






45. The ______ in the BM are DN - the DP are in the cortex of thymus






46. what prevents NK cells from killing normal cells if their default is to kill?






47. Give an example of someone who could get hyperacute transplant rejection.






48. Name two endogenous pyrogens






49. In thymic development - What is the positive selection? negative selections?






50. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example