Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Describe the capsular structure of a lymph node; What are the functions of the LN?






2. Type Iv hypersensitivity is...






3. What is the presentation of scid? treatment?






4. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






5. What is the main cytokine that activates eosinophils?






6. A lymph node is a ________ lymphoid organ.






7. To what portion of the Antibody do the complements bind?






8. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






9. where do NK cells develop?






10. which type of immunity is slow but long lasting? as opposed to...






11. How does complement link innate and adaptive?






12. What are the two signals required for B cell class switching? Which is the second signal?






13. The lymphocytes are ________ origin






14. What cytokines to Th2 secrete?






15. What lymph node drains the thigh?






16. What lymph node drains the scrotum?






17. Other than stimulating fever - what else does IL 6 do?






18. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






19. What is the toxicity of muromonab?






20. Which MHC presents intracellular peptides? how so?






21. what characterizes an arthus reaction?






22. What is a factor that is a predictor for a bad transplantation?






23. What are the autoantibodies for myasthenia gravis?






24. Which antibody mediates immunity to worms? how?






25. Describe the Mannose Lectin pathway






26. How fast does it occur?






27. what results in symptoms of shock in an acute hemolytic transfusion reaction?






28. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






29. other than eat and bite RBCs what else do Macrophages of spleen do>






30. IgM can fix complement but...






31. What are C1 - C2 - C3 - C4 important for?






32. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






33. Which diseases are associated with DR5?






34. What is the main function of IL 8?






35. What is the pathogenesis of HyperIgE syndrome? What are the labs?






36. describe the pathogenesis of delayed type IV hypersensitivity






37. What is the general structure of an Ab?






38. What are the autoantibodies for polymyositis and dermatomyositis?






39. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






40. What are MHC's necessary for? By themselves?






41. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






42. What is oprelevkin? and What is it used for?






43. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






44. What is thrombopoietin used for?






45. what cell surface marker is used for NK cells as it is unique to them?






46. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






47. Describe the complement independent Type II hypersenstivity reaction. Give an example.






48. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






49. What are the T cell functions?






50. What are the autoantibodies for systemic sclerosis?