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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






2. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






3. Which are the only two antiinflammatory cytokines?






4. What is filgrastim and sargramostim? and What is it used for?






5. Only the _______ contribute to the Fc region






6. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






7. What are the main cell surface proteins on B cells?






8. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






9. What does IL 2 do?






10. What are the autoantibodies for polymyositis and dermatomyositis?






11. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






12. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






13. What is the mechanism for sirolimus? what else it known as?






14. What are the main symptoms of B cell immunodeficiencies?






15. What are the two signals required for Th1 cells? what happens after then activated?






16. ________ regulate the cell mediated response.






17. which antibodies prevent antigens from binding mucosal surfaces?






18. What is the most common selective Ig deficiency? What is the presentation?






19. What is the presentation of hyperIgM syndrome?






20. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






21. What bugs can actually infect the lymph node itself?






22. The secondary follicles have __________; primary follicles are dense






23. In general What are T cells good for?






24. What are superantigens? give two examples.






25. Monomer in circulation - ___ when secreted






26. What is the common variable immunodeficiency ? How is it different from Brutons?






27. What does interferon gamma do? What two type of cells does it attack mostly?






28. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






29. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






30. Which cytokines do Th2 release and For what?






31. What does IL 10 do? who is secreted by?






32. How fast does it occur?






33. What are the autoantibodies for autoimmune hepatitis?






34. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






35. Which HLA's are included in MHC I? MHC II?

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36. Describe the capsular structure of a lymph node; What are the functions of the LN?






37. The Fc region is found on the...






38. The ______ in the BM are DN - the DP are in the cortex of thymus






39. What is oprelevkin? and What is it used for?






40. What type of fenestrations are found in the red pulp of the spleen?






41. What is colostrum?






42. Type IV hypersensitivity is i...






43. What is the pathogenesis of HyperIgE syndrome? What are the labs?






44. which interleukin receptor is required for NK development? activation?






45. How is the thymus organized? what happens in each section?






46. What are the three types of APCs?






47. What are the two signals required for B cell class switching? Which is the second signal?






48. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






49. What is the main function of IL 12? other than macrophages who else can release IL 12?






50. where are complements produced?