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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for graves?






2. which cytokine inhibits TH2 cells? secreted by who?






3. How does igA cross the epithelium?






4. Which antibodies can be multimeric?






5. What is a factor that is a predictor for a bad transplantation?






6. which of the transplant rejections is antibody mediated? why does it occur?






7. What is a type I hypersensitivity reaction? What is atopic?






8. What are the symptoms of serum sickness?






9. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






10. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






11. What is serum sickness? give an example.






12. What are C1 - C2 - C3 - C4 important for?






13. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






14. What is recomb gamma interferon used for?






15. IgE has the ___________ in the serum






16. What are the main Cell surface proteins on T cells?






17. What are some sinopulmonary infections?






18. what will NK cells do to cells covered in IgG Ab? why?






19. What are the cell surface proteins on NK cells?






20. where are complements produced?






21. describe the pathogenesis of delayed type IV hypersensitivity






22. What is the treatment of acute transplant rejection?






23. Which disease is associated with DR7?






24. What are the autoantibodies for drug induced lupus?






25. Name the three opsonins






26. What links the adaptive and innate immunity?






27. when can graft versus host disease? What is the result?






28. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






29. What is oprelevkin? and What is it used for?






30. What do multimeric antibodies require for assembly?






31. What lymph node drains the scrotum?






32. IgM can exist as a _______ also






33. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






34. What are the autoantibodies for other vasculitides?






35. What are four results of a splenectomy?






36. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






37. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






38. What are the cell surface proteins for Macrophages? which two are for opsonins?






39. The MALT/GALT are not...






40. What happens in a secondary follicle?






41. What is the pathogenesis of a candida skin test?






42. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






43. what characterizes an arthus reaction?






44. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






45. What does granzyme do? who secretes it?






46. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






47. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






48. describe the classic complement pathway.






49. What lymph node drains the breast?






50. what mediates the type II hypersensitivity? What are the two different methods?