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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Describe the capsular structure of a lymph node; What are the functions of the LN?






2. Type IV hypersensitivity is i...






3. The lymphocytes are ________ origin






4. What does IL 4 do?






5. which antibodies can bind complement?






6. What are the cell surface proteins on NK cells?






7. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






8. other than eat and bite RBCs what else do Macrophages of spleen do>






9. what bacteria are a splenectomy patient most susceptible to? why?






10. What are the autoantibodies for drug induced lupus?






11. What do multimeric antibodies require for assembly?






12. IgM can exist as a _______ also






13. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






14. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






15. What kinds of receptors activate innate immunity?






16. Which antibody mediates immunity to worms? how?






17. Which disease is associated with B8?






18. What is chronic mucocutaneous candidiasis d/t?






19. What is the presentation of Brutons agammaglobulinemia?






20. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






21. which interleukin receptor is required for NK development? activation?






22. What is the main function of interferons?






23. ________ regulate the cell mediated response.






24. What is recomb gamma interferon used for?






25. which cells have more complete tolerance - B or T cells?






26. How does igA cross the epithelium?






27. Describe complement dependent Type II hypersensitivity. Give an example.






28. What is the autoantibody for SLE that is nonspecific? Specific?






29. What is the main function of IL 8?






30. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






31. what ensure that a memory response is generated?






32. What is the mechanism for sirolimus? what else it known as?






33. Other than stimulating fever - what else does IL 6 do?






34. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






35. __________ are a part of the innate system.






36. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






37. What is the common variable immunodeficiency ? How is it different from Brutons?






38. What is the most common example of passive immunity?






39. What are the two signals required for Th1 cells? what happens after then activated?






40. The ______ in the BM are DN - the DP are in the cortex of thymus






41. What are the autoantibodies for Mixed connective tissue disease?






42. describe the pathogenesis of delayed type IV hypersensitivity






43. Which diseases are associated with DR5?






44. What is the presentation of common variable immunodef? and What are the labs?






45. For which toxins are preformed antibodies (passive) given?






46. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






47. what results in symptoms of shock in an acute hemolytic transfusion reaction?






48. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






49. Which diseases are associated with DR4?






50. What are the autoantibodies for Celiac disease?