Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the upper limb?






2. What are C1 - C2 - C3 - C4 important for?






3. What is the pathogenesis of HyperIgE syndrome? What are the labs?






4. What is recomb beta interferon used for?






5. what will NK cells do to cells covered in IgG Ab? why?






6. What are the main cell surface proteins on B cells?






7. What is hereditary angioedema? What are the C3 levels?






8. What does IgA pick up from epithelial cells before being secreted?






9. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






10. Which disease is associated with DR7?






11. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






12. What are target cells?






13. What are the three types of lymphocytes?






14. what characterizes an arthus reaction?






15. What are the autoantibodies for goodpastures syndrome?






16. what happens in a deficiency of C1 esterase inhibitor? DAF?






17. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






18. How do you test for chronic granulomatous disease?






19. What is the receptor for EBV? On what cells is that located?






20. What does granulysin do?






21. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






22. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






23. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






24. What is the pathogenesis of a hypersensitivity reaction?






25. are Th cells involved in trapping of antigens of endotoxin/LPS?






26. What is Aldesleukin? What is it used for






27. Which is the most abundant antibody in blood?






28. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






29. which of the transplant rejections is antibody mediated? why does it occur?






30. What are the autoantibodies for type I diabetes mellitus?






31. ________ regulate the cell mediated response.






32. Which disease is associated with HLA A3?






33. What is the autoantibody for SLE that is nonspecific? Specific?






34. The secondary follicles have __________; primary follicles are dense






35. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






36. T/F B cells do not require a second signal






37. Describe the complement independent Type II hypersenstivity reaction. Give an example.






38. What lymph node drains the stomach?






39. What lymph node drains the anal canal (below the pectinate line)?






40. hat is the presentation of Jobs syndrome or Hyper IgE?






41. other than C3a - what other complement acts as an anaphyloxin?






42. How is sirolimus different from tacrolimus?






43. What is the late phase reaction of anaphylaxis allergy? what mediates it?






44. What is filgrastim and sargramostim? and What is it used for?






45. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






46. Describe complement dependent Type II hypersensitivity. Give an example.






47. What lymph node drains the rectum (above the pectinate line)?






48. In general What are T cells good for?






49. Which diseases are associated with DR4?






50. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response