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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What does granzyme do? who secretes it?






2. What are the autoantibodies for graves?






3. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






4. The secondary follicles have __________; primary follicles are dense






5. where do somatic hypermutation and class switching occur?






6. What is the clinical use of Muromonab?






7. what cell surface proteins are on all APCs?






8. What is the main function of interferons?






9. What are the autoantibodies for autoimmune hepatitis?






10. What lymph node drains the scrotum?






11. What are the T cell functions?






12. which cells have more complete tolerance - B or T cells?






13. What are the autoantibodies for Celiac disease?






14. which interleukin receptor is required for NK development? activation?






15. What is the pathology of acute transplant rejection? is it reversible?






16. What does IL 10 do? who is secreted by?






17. what will NK cells do to cells covered in IgG Ab? why?






18. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






19. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






20. Describe the Mannose Lectin pathway






21. What are the autoantibodies for primary biliary cirrhosis?






22. describe the classic complement pathway.






23. which B and T cell disorder presents with specifically low IgM?






24. other than C3a - what other complement acts as an anaphyloxin?






25. What are the labs in brutons agammaglobulinemia?






26. So antibodies are the effectors for the humoral response. List some of their functions.






27. Which diseases are associated with DR2?






28. which antibody is involved in the primary response or immediate response to an antigen?






29. Describe complement dependent Type II hypersensitivity. Give an example.






30. What is Aldesleukin? What is it used for






31. What happens in a deficiency of C3?






32. What do multimeric antibodies require for assembly?






33. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






34. What are howell jolly bodies?






35. What lymph node drains the sigmoid colon?






36. What does IL 2 do?






37. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






38. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






39. What is colostrum?






40. Which disease is associated with DR7?






41. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






42. What are the symptoms of serum sickness?






43. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






44. What are C1 - C2 - C3 - C4 important for?






45. Type Iv hypersensitivity is...






46. What is recomb gamma interferon used for?






47. The two heavy chains of an antibody contribute to the...






48. What are target cells?






49. What are the main cell surface proteins on B cells?






50. In thymic development - What is the positive selection? negative selections?