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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which interleukin receptor is required for NK development? activation?






2. in which immunodef order do you see a lot of pus? no pus?






3. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






4. What is epo used for?






5. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






6. How do you test for type III hypersensitivity?






7. What does IL 5 do?






8. What are the two signals required for B cell class switching? Which is the second signal?






9. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






10. What does IL 10 do? who is secreted by?






11. What are the autoantibodies for wegeners granulomatosis?






12. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






13. Which are the only two antiinflammatory cytokines?






14. What are the cell surface proteins for Macrophages? which two are for opsonins?






15. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






16. What is serum sickness? give an example.






17. What are target cells?






18. Monomer in circulation - ___ when secreted






19. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






20. Which antibodies can be multimeric?






21. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






22. What is the toxicity of azathioprine?






23. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






24. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






25. What is the pathogenesis of a candida skin test?






26. What links the adaptive and innate immunity?






27. To what disease do the autoantibodies to IgG (rheumatoid factor)?






28. What lymph node drains the stomach?






29. From where do cytokines come from?






30. What are the autoantibodies for Mixed connective tissue disease?






31. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






32. What are the autoantibodies for graves?






33. What is oprelevkin? and What is it used for?






34. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






35. ________ regulate the cell mediated response.






36. What is the pathogenesis of acute transplant rejection? When does it occur?






37. What is recomb gamma interferon used for?






38. What are the autoantibodies for Celiac disease?






39. What do mature naive B lymphocytes express?






40. give an example of how influenza does a major antigenic shift.






41. What are the autoantibodies for systemic sclerosis?






42. What is thrombopoietin used for?






43. What are the symptoms of serum sickness?






44. Only the _______ contribute to the Fc region






45. What is the main function of interferons?






46. What is the cause of thymic aplasia? What is its presentation? What are the labs?






47. which antibodies can bind complement?






48. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






49. In general What are T cells good for?






50. Complements are...