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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?

2. What lymph node drains the sigmoid colon?

3. Give an example of someone who could get hyperacute transplant rejection.

4. What are the autoantibodies for drug induced lupus?

5. what secretes IL 4?

6. What is the pathology of acute transplant rejection? is it reversible?

7. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?

8. In thymic development - What is the positive selection? negative selections?

9. Which is the main antibody in the delayed or secondary response to an antigen?

10. T/F B cells do not require a second signal

11. What is the general structure of an Ab?

12. Type Iv hypersensitivity is...

13. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?

14. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?

15. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?

16. What is chronic mucocutaneous candidiasis d/t?

17. What is the mechanism for sirolimus? what else it known as?

18. which cells have more complete tolerance - B or T cells?

19. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?

20. What are the autoantibodies for autoimmune hepatitis?

21. What is the pathogenesis of HyperIgE syndrome? What are the labs?

22. what results in symptoms of shock in an acute hemolytic transfusion reaction?

23. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?

24. What are the two signals required for B cell class switching? Which is the second signal?

25. What portion of the lymph node is not well developed in DiGeorge Syndrome?

26. What are the two signals required for T cells? what happens after?

27. What is the toxicity of azathioprine?

28. where are complements produced?

29. What is the white pulp of the spleen?

30. What is recomb beta interferon used for?

31. What is the presentation of hyperIgM syndrome?

32. What is recomb alpha interferon used for?

33. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?

34. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?

35. What is passive immunity?

36. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?

37. What lymph node drains the testes?

38. Name 5 ways Antibody diversity is generated?

39. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?

40. What does granzyme do? who secretes it?

41. What are the T cell functions?

42. Only the _______ contribute to the Fc region

43. What is digoxin immune Fab used for?

44. What type of side chains are found on Fc region of an antibody?

45. What is the end result of complement activation? what bugs are this important for? through what pathway and why?

46. can igG cross the placenta?

47. Which helper T cells' development is induced by IL 4? IL 12?

48. The idiotype; the Fc portion determines the...

49. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?

50. What are the autoantibodies for sjorgens syndrome?