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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What does granulysin do?






2. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






3. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






4. What is the pathogenesis of a hypersensitivity reaction?






5. Which diseases are associated with DR2?






6. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






7. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






8. in which immunodef order do you see a lot of pus? no pus?






9. What does Interferon alpha and beta do? how?






10. which cytokine inhibits TH2 cells? secreted by who?






11. What is the cause of thymic aplasia? What is its presentation? What are the labs?






12. other than mediating shock - what else does TNF alpha do? who releases it mainly?






13. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






14. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






15. What are the autoantibodies for hashimotos?






16. What are the cell surface proteins for Macrophages? which two are for opsonins?






17. What do multimeric antibodies require for assembly?






18. What are the main symptoms of B cell immunodeficiencies?






19. What is oprelevkin? and What is it used for?






20. What bugs can actually infect the lymph node itself?






21. Which antibodies can be multimeric?






22. where are complements produced?






23. What is digoxin immune Fab used for?






24. What is epo used for?






25. what cell surface marker is used for NK cells as it is unique to them?






26. What are target cells?






27. What is the late phase reaction of anaphylaxis allergy? what mediates it?






28. What is the toxicity of muromonab?






29. What is a type I hypersensitivity reaction? What is atopic?






30. Which is the most abundant antibody in blood?






31. Other than stimulating fever - what else does IL 6 do?






32. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






33. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






34. What are the T cell functions?






35. What are the autoantibodies for systemic sclerosis?






36. What are the function of B cells?






37. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






38. What can cause a lymph node enlargement?






39. What is the treatment of acute transplant rejection?






40. What is the main function of interferons?






41. What links the adaptive and innate immunity?






42. What is the pathogenesis of a candida skin test?






43. describe the classic complement pathway.






44. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






45. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






46. What lymph node drains the stomach?






47. So antibodies are the effectors for the humoral response. List some of their functions.






48. Leukocyte adhesion defect presents with...






49. What is the pathogenesis of HyperIgE syndrome? What are the labs?






50. How does complement link innate and adaptive?