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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is anergy? why does this occur?






2. Which disease is associated withB B27?






3. To what disease do the autoantibodies to IgG (rheumatoid factor)?






4. what characterizes an arthus reaction?






5. How is the antigen loaded onto a MHC II?






6. Which is the main antibody that provides passive immunity to infants?






7. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






8. what cell surface proteins are on all APCs?






9. which interleukin receptor is required for NK development? activation?






10. The pathogenesis of contact dermatitis is ________ hypersensitivity






11. What are the autoantibodies for type I diabetes mellitus?






12. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






13. A lymph node is a ________ lymphoid organ.






14. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






15. What lymph node drains the sigmoid colon?






16. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






17. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






18. Which HLA's are included in MHC I? MHC II?

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19. What is three common causes of severe combined immunodef? What is the result of all three?






20. Which helper T cells' development is induced by IL 4? IL 12?






21. what secretes IL 4?






22. describe the classic complement pathway.






23. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






24. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






25. what ensure that a memory response is generated?






26. What are the two signals required for T cells? what happens after?






27. Describe the Mannose Lectin pathway






28. What are target cells?






29. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






30. What are C1 - C2 - C3 - C4 important for?






31. What is a type I hypersensitivity reaction? What is atopic?






32. Leukocyte adhesion defect presents with...






33. Which antibodies can be multimeric?






34. What is the most common selective Ig deficiency? What is the presentation?






35. Which diseases are associated with DR4?






36. The alternative pathway is the only constutively...






37. Which disease is associated with HLA A3?






38. What are MHC's necessary for? By themselves?






39. What is Aldesleukin? What is it used for






40. What is the most common example of passive immunity?






41. What is the presentation of hyperIgM syndrome?






42. What are the autoantibodies for primary biliary cirrhosis?






43. What lymph node drains the duodenum - jejunum?






44. Other than stimulating fever - what else does IL 6 do?






45. hat is the presentation of Jobs syndrome or Hyper IgE?






46. What is a factor that is a predictor for a bad transplantation?






47. What is the toxicity of muromonab?






48. What are the function of B cells?






49. Describe the capsular structure of a lymph node; What are the functions of the LN?






50. What does IL 2 do?







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