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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which type of selection of thymic development provides central tolerance?






2. Give three examples of bacteria that use antigenic variation and how.






3. What are the autoantibodies for pemphigus bulgaris?






4. What is the pathogenesis of a hypersensitivity reaction?






5. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






6. Describe the Mannose Lectin pathway






7. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






8. which antibodies can bind complement?






9. What is a factor that is a predictor for a bad transplantation?






10. What is the pathogenesis of a candida skin test?






11. Which is the main antibody in the delayed or secondary response to an antigen?






12. Which diseases are associated with DR4?






13. What lymph node drains the upper limb?






14. What is the main function of interferons?






15. The MALT/GALT are not...






16. How is i Th1 helper cell inhibited?






17. IgM can fix complement but...






18. Which disease is associated with DR7?






19. Type Iv hypersensitivity is...






20. What is the pathogenesis of acute transplant rejection? When does it occur?






21. describe the pathogenesis of delayed type IV hypersensitivity






22. What are the major functions of Antibodies?






23. So antibodies are the effectors for the humoral response. List some of their functions.






24. What type of side chains are found on Fc region of an antibody?






25. What are the function of B cells?






26. What are the autoantibodies for hashimotos?






27. describe the classic complement pathway.






28. How does the alternative pathway lead to MAC activation?






29. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






30. What is the cause of thymic aplasia? What is its presentation? What are the labs?






31. The Fc region is found on the...






32. What are the main Cell surface proteins on T cells?






33. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






34. What is digoxin immune Fab used for?






35. What is the marginal zone of the spleen? what happens there?






36. what will NK cells do to cells covered in IgG Ab? why?






37. ________ regulate the cell mediated response.






38. Name 5 ways Antibody diversity is generated?






39. What is hereditary angioedema? What are the C3 levels?






40. What are the autoantibodies for wegeners granulomatosis?






41. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






42. What are the autoantibodies for graves?






43. What are the main symptoms of B cell immunodeficiencies?






44. What is the pathology in hyperacute transplant rejection?






45. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






46. What happens in a deficiency of C3?






47. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






48. What is Aldesleukin? What is it used for






49. What is the treatment of acute transplant rejection?






50. What are the two signals required for Th1 cells? what happens after then activated?