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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. where do somatic hypermutation and class switching occur?






2. Which is the most abundant antibody in blood?






3. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






4. Name the three opsonins






5. What type of fenestrations are found in the red pulp of the spleen?






6. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






7. What is the main function of IL 12? other than macrophages who else can release IL 12?






8. In general What are T cells good for?






9. T/F B cells do not require a second signal






10. describe the classic complement pathway.






11. What are C1 - C2 - C3 - C4 important for?






12. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






13. What is chronic mucocutaneous candidiasis d/t?






14. Type IV hypersensitivity is i...






15. Which disease is associated with B8?






16. What happens in a secondary follicle?






17. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






18. where do NK cells develop?






19. what cytokine does basophils secrete?






20. what happens in a deficiency of C1 esterase inhibitor? DAF?






21. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






22. which antibodies prevent antigens from binding mucosal surfaces?






23. What is the main function of IL 8?






24. which antibodies can bind complement?






25. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






26. What is the pathology of acute transplant rejection? is it reversible?






27. What lymph node drains the duodenum - jejunum?






28. What is the presentation of common variable immunodef? and What are the labs?






29. What is recomb gamma interferon used for?






30. Which antibodies can be multimeric?






31. What is the clinical use for sirolimus? what should you combine it with?






32. what ensure that a memory response is generated?






33. How does the alternative pathway lead to MAC activation?






34. The pathogenesis of contact dermatitis is ________ hypersensitivity






35. What is recomb alpha interferon used for?






36. What are the T cell functions?






37. The two heavy chains of an antibody contribute to the...






38. Monomer in circulation - ___ when secreted






39. what characterizes an arthus reaction?






40. What are the two signals required for T cells? what happens after?






41. How is sirolimus different from tacrolimus?






42. which antibody activate mast cells - basophils - and eosinophils?






43. What are the mediators that mast cells release?






44. What kinds of receptors activate innate immunity?






45. where are complements produced?






46. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






47. What does granzyme do? who secretes it?






48. Which diseases are associated with DR2?






49. The alternative pathway is the only constutively...






50. What does IL 4 do?







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