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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which HLA's are included in MHC I? MHC II?

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2. What are the function of B cells?






3. What is the receptor for EBV? On what cells is that located?






4. What does interferon gamma do? What two type of cells does it attack mostly?






5. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






6. T/F B cells do not require a second signal






7. What are the labs in brutons agammaglobulinemia?






8. What is the clinical use for azathioprine?






9. which of the hypersensitivity reactions is not Ab mediated?






10. Name the three opsonins






11. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






12. are Th cells involved in trapping of antigens of endotoxin/LPS?






13. is IgM an opsonizer?






14. What does IgA pick up from epithelial cells before being secreted?






15. Name two endogenous pyrogens






16. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






17. What is the general structure of an Ab?






18. How do you test for chronic granulomatous disease?






19. What lymph node drains the thigh?






20. What is the presentation of scid? treatment?






21. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






22. What is anergy? why does this occur?






23. what happens in a deficiency of C1 esterase inhibitor? DAF?






24. What cytokines are released by Th1 cells?






25. what ensure that a memory response is generated?






26. What type of side chains are found on Fc region of an antibody?






27. Leukocyte adhesion defect presents with...






28. What are four results of a splenectomy?






29. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






30. The idiotype; the Fc portion determines the...






31. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






32. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






33. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






34. Which helper T cells' development is induced by IL 4? IL 12?






35. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






36. where are complements produced?






37. What is the pathology of acute transplant rejection? is it reversible?






38. Which disease is associated withB B27?






39. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






40. What are the main Cell surface proteins on T cells?






41. describe the pathogenesis of delayed type IV hypersensitivity






42. What does granulysin do?






43. what results in symptoms of shock in an acute hemolytic transfusion reaction?






44. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






45. What are the main symptoms of T cell immunodeficiencies?






46. What is the main function of IL 12? other than macrophages who else can release IL 12?






47. Which cytokines do Th2 release and For what?






48. What is the treatment of acute transplant rejection?






49. Which antibodies can be multimeric?






50. Give an example of someone who could get hyperacute transplant rejection.






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