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USMLE Step 1 Immunology

  • Answer 50 questions in 15 minutes.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the breast?

2. What happens in a deficiency of C3?

3. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?

4. How do you test for type III hypersensitivity?

5. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?

6. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example

7. which cytokine inhibits TH2 cells? secreted by who?

8. The alternative pathway is the only constutively...

9. which antibodies can bind complement?

10. Which disease is associated withB B27?

11. what prevents NK cells from killing normal cells if their default is to kill?

12. What happens in a secondary follicle?

13. What are the autoantibodies for wegeners granulomatosis?

14. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?

15. can igG cross the placenta?

16. where do NK cells develop?

17. which cells have more complete tolerance - B or T cells?

18. when can graft versus host disease? What is the result?

19. describe the pathogenesis of delayed type IV hypersensitivity

20. What bugs can actually infect the lymph node itself?

21. What are the major functions of Antibodies?

22. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1

23. IgM can fix complement but...

24. Which disease is associated with DR7?

25. How does complement link innate and adaptive?

26. What is the marginal zone of the spleen? what happens there?

27. describe the classic complement pathway.

28. In thymic development - What is the positive selection? negative selections?

29. Which is the main antibody that provides passive immunity to infants?

30. How is the thymus organized? what happens in each section?

31. What does granulysin do?

32. What are the autoantibodies for pernicious anemia?

33. What is the most common example of passive immunity?

34. What is the pathogenesis of HyperIgE syndrome? What are the labs?

35. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?

36. What are the autoantibodies for primary biliary cirrhosis?

37. What is the autoantibody for SLE that is nonspecific? Specific?

38. What type of side chains are found on Fc region of an antibody?

39. What are the autoantibodies for polymyositis and dermatomyositis?

40. What are the autoantibodies for Mixed connective tissue disease?

41. what cell surface proteins are on all APCs?

42. T/F B cells do not require a second signal

43. what happens in order for class switching to occur (after being activated by IL and cd40 L)?

44. What is hereditary angioedema? What are the C3 levels?

45. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).

46. For which toxins are preformed antibodies (passive) given?

47. which of the hypersensitivity reactions is not Ab mediated?

48. What does CD16 on NK cells do?

49. Describe the capsular structure of a lymph node; What are the functions of the LN?

50. How is the antigen loaded onto a MHC II?