Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which of the hypersensitivity reactions is not Ab mediated?






2. what characterizes an arthus reaction?






3. From where do cytokines come from?






4. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






5. What are the autoantibodies for pernicious anemia?






6. What are MHC's necessary for? By themselves?






7. hat is the presentation of Jobs syndrome or Hyper IgE?






8. What is colostrum?






9. In general What are T cells good for?






10. What does IgA pick up from epithelial cells before being secreted?






11. The lymphocytes are ________ origin






12. What is the treatment of acute transplant rejection?






13. Type IV hypersensitivity is i...






14. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






15. Which MHC presents intracellular peptides? how so?






16. What do multimeric antibodies require for assembly?






17. What are the autoantibodies for drug induced lupus?






18. What lymph node drains the duodenum - jejunum?






19. What are the two signals required for T cells? what happens after?






20. What is the main cytokine released by T cells? What does it do






21. What is Aldesleukin? What is it used for






22. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






23. Name 5 ways Antibody diversity is generated?






24. What lymph node drains the upper limb?






25. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






26. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






27. which antibody is involved in the primary response or immediate response to an antigen?






28. which of the transplant rejections is antibody mediated? why does it occur?






29. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






30. How is the antigen loaded onto a MHC II?






31. What bugs can actually infect the lymph node itself?






32. Describe the complement independent Type II hypersenstivity reaction. Give an example.






33. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






34. What are the autoantibodies for hashimotos?






35. Which type of selection of thymic development provides central tolerance?






36. In thymic development - What is the positive selection? negative selections?






37. The two heavy chains of an antibody contribute to the...






38. The Fc region is found on the...






39. What are the autoantibodies for goodpastures syndrome?






40. What is chronic mucocutaneous candidiasis d/t?






41. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






42. What are the main symptoms of B cell immunodeficiencies?






43. what ensure that a memory response is generated?






44. What are the autoantibodies for systemic sclerosis?






45. Which disease is associated with DR7?






46. What is the most common example of passive immunity?






47. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






48. what results in symptoms of shock in an acute hemolytic transfusion reaction?






49. What is thrombopoietin used for?






50. To what disease do the autoantibodies to IgG (rheumatoid factor)?