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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the presentation of common variable immunodef? and What are the labs?

2. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?

3. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?

4. How fast does it occur?

5. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?

6. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?

7. Monomer in circulation - ___ when secreted

8. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?

9. How is i Th1 helper cell inhibited?

10. What are the autoantibodies for myasthenia gravis?

11. IgE has the ___________ in the serum

12. what characterizes an arthus reaction?

13. Which diseases are associated with DR5?

14. How does igA cross the epithelium?

15. Which disease is associated with DR7?

16. What can cause a lymph node enlargement?

17. What is hereditary angioedema? What are the C3 levels?

18. What is a type I hypersensitivity reaction? What is atopic?

19. What is the defect in hyper IgM syndrome? What are the lab results?

20. Which HLA's are included in MHC I? MHC II?

21. Which type of selection of thymic development provides central tolerance?

22. Describe the complement independent Type II hypersenstivity reaction. Give an example.

23. How is the thymus organized? what happens in each section?

24. What is the mechanism for sirolimus? what else it known as?

25. What are the two signals required for B cell class switching? Which is the second signal?

26. Type IV hypersensitivity is i...

27. What lymph node drains the duodenum - jejunum?

28. What type of fenestrations are found in the red pulp of the spleen?

29. What is the presentation of hyperIgM syndrome?

30. which antibodies prevent antigens from binding mucosal surfaces?

31. To what disease do the autoantibodies to IgG (rheumatoid factor)?

32. What are the autoantibodies for drug induced lupus?

33. what happens in a deficiency of C1 esterase inhibitor? DAF?

34. How does complement link innate and adaptive?

35. What are the three types of lymphocytes?

36. What is the main cytokine released by T cells? What does it do

37. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response

38. The alternative pathway is the only constutively...

39. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?

40. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?

41. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?

42. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?

43. What is the pathogenesis of HyperIgE syndrome? What are the labs?

44. give an example of how influenza does a major antigenic shift.

45. What lymph node drains the anal canal (below the pectinate line)?

46. What links the adaptive and innate immunity?

47. What are the autoantibodies for hashimotos?

48. What do mature naive B lymphocytes express?

49. What is colostrum?

50. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?