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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






2. What is muromonab - CD3 (OKT3)






3. Complements are...






4. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






5. What is the clinical use for azathioprine?






6. From where do cytokines come from?






7. which B and T cell disorder presents with specifically low IgM?






8. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






9. Leukocyte adhesion defect presents with...






10. Which diseases are associated with DR4?






11. The Fc region is found on the...






12. Which HLA's are included in MHC I? MHC II?

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13. ________ regulate the cell mediated response.






14. What are the autoantibodies for Celiac disease?






15. How do you test for type III hypersensitivity?






16. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






17. are Th cells involved in trapping of antigens of endotoxin/LPS?






18. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






19. What is the late phase reaction of anaphylaxis allergy? what mediates it?






20. What are the two signals required for T cells? what happens after?






21. How fast does it occur?






22. The pathogenesis of contact dermatitis is ________ hypersensitivity






23. Describe complement dependent Type II hypersensitivity. Give an example.






24. other than mediating shock - what else does TNF alpha do? who releases it mainly?






25. describe the classic complement pathway.






26. How is sirolimus different from tacrolimus?






27. which type of immunity is slow but long lasting? as opposed to...






28. What lymph node drains the thigh?






29. What is the pathogenesis of acute transplant rejection? When does it occur?






30. which antibodies can bind complement?






31. What does IL 4 do?






32. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






33. What are the autoantibodies for myasthenia gravis?






34. What is three common causes of severe combined immunodef? What is the result of all three?






35. What is the most common selective Ig deficiency? What is the presentation?






36. which interleukin receptor is required for NK development? activation?






37. where are complements produced?






38. How is the antigen loaded onto a MHC II?






39. which antibodies prevent antigens from binding mucosal surfaces?






40. What does it mean if there are igM in the serum at birth?






41. What is recomb alpha interferon used for?






42. What are C1 - C2 - C3 - C4 important for?






43. Which antibodies can be multimeric?






44. What are the autoantibodies for autoimmune hepatitis?






45. describe the pathogenesis of delayed type IV hypersensitivity






46. What are the main cell surface proteins on B cells?






47. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






48. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






49. Only the _______ contribute to the Fc region






50. What are the PALS?







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