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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. IgM can exist as a _______ also






2. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






3. What does IL 4 do?






4. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






5. In thymic development - What is the positive selection? negative selections?






6. What are the autoantibodies for goodpastures syndrome?






7. What are the autoantibodies for pernicious anemia?






8. What are the autoantibodies for polymyositis and dermatomyositis?






9. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






10. What is passive immunity?






11. What are the autoantibodies for autoimmune hepatitis?






12. Name the three opsonins






13. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






14. What are the function of B cells?






15. where do somatic hypermutation and class switching occur?






16. ________ regulate the cell mediated response.






17. What are the autoantibodies for sjorgens syndrome?






18. Which HLA's are included in MHC I? MHC II?

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19. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






20. What does IL 10 do? who is secreted by?






21. What are some catalase positive organisms?






22. What happens in a deficiency of C3?






23. What are the autoantibodies for systemic sclerosis?






24. To what disease do the autoantibodies to IgG (rheumatoid factor)?






25. What is epo used for?






26. What lymph node drains the rectum (above the pectinate line)?






27. What do mature naive B lymphocytes express?






28. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






29. What are the main symptoms of T cell immunodeficiencies?






30. What is recomb beta interferon used for?






31. other than eat and bite RBCs what else do Macrophages of spleen do>






32. What lymph node drains the lateral side of the dorsum of the foot?






33. What are the cell surface proteins on NK cells?






34. Leukocyte adhesion defect presents with...






35. Which type of selection of thymic development provides central tolerance?






36. what cell surface marker is used for NK cells as it is unique to them?






37. what mediates the type II hypersensitivity? What are the two different methods?






38. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






39. give an example of how influenza does a major antigenic shift.






40. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






41. Which diseases are associated with DR5?






42. What are the autoantibodies for pemphigus bulgaris?






43. other than mediating shock - what else does TNF alpha do? who releases it mainly?






44. The pathogenesis of contact dermatitis is ________ hypersensitivity






45. Which disease is associated with DR7?






46. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






47. where do NK cells develop?






48. What lymph node drains the sigmoid colon?






49. What are the PALS?






50. What are the two signals to kill for NK cells?







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