Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. in which immunodef order do you see a lot of pus? no pus?






2. What do multimeric antibodies require for assembly?






3. What is the pathogenesis of a hypersensitivity reaction?






4. IgG...






5. What are some catalase positive organisms?






6. What does granzyme do? who secretes it?






7. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






8. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






9. What is recomb beta interferon used for?






10. What are the two signals required for T cells? what happens after?






11. What is the main function of TNF alpha? How does it do this?






12. What is the most common example of passive immunity?






13. What is muromonab - CD3 (OKT3)






14. What is the pathology in hyperacute transplant rejection?






15. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






16. Which is the main antibody in the delayed or secondary response to an antigen?






17. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






18. What is a type I hypersensitivity reaction? What is atopic?






19. Type Iv hypersensitivity is...






20. What is the most common selective Ig deficiency? What is the presentation?






21. What is epo used for?






22. What are the autoantibodies for Mixed connective tissue disease?






23. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






24. What are the autoantibodies for autoimmune hepatitis?






25. what results in symptoms of shock in an acute hemolytic transfusion reaction?






26. Name two endogenous pyrogens






27. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






28. What is passive immunity?






29. What is the pathogenesis of HyperIgE syndrome? What are the labs?






30. describe the classic complement pathway.






31. What are the autoantibodies for myasthenia gravis?






32. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






33. So antibodies are the effectors for the humoral response. List some of their functions.






34. Name the three opsonins






35. what will NK cells do to cells covered in IgG Ab? why?






36. What are the two signals required for Th1 cells? what happens after then activated?






37. What is the presentation of Brutons agammaglobulinemia?






38. What are MHC's necessary for? By themselves?






39. which antibodies prevent antigens from binding mucosal surfaces?






40. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






41. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






42. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






43. What is the toxicity of muromonab?






44. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






45. What are the autoantibodies for systemic sclerosis?






46. What lymph node drains the upper limb?






47. What are the autoantibodies for type I diabetes mellitus?






48. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






49. In general What are T cells good for?






50. give an example of how influenza does a major antigenic shift.