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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the mechanism for sirolimus? what else it known as?






2. What is a type I hypersensitivity reaction? What is atopic?






3. The alternative pathway is the only constutively...






4. What lymph node drains the rectum (above the pectinate line)?






5. What are some catalase positive organisms?






6. Which diseases are associated with DR4?






7. What are the symptoms of serum sickness?






8. What is the most common example of passive immunity?






9. Which is the main antibody that provides passive immunity to infants?






10. Which diseases are associated with DR2?






11. What is recomb alpha interferon used for?






12. what secretes IL 4?






13. What are the two signals required for B cell class switching? Which is the second signal?






14. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






15. What are the autoantibodies for primary biliary cirrhosis?






16. What are the autoantibodies for Mixed connective tissue disease?






17. What is the white pulp of the spleen?






18. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






19. Name two endogenous pyrogens






20. What is the most common selective Ig deficiency? What is the presentation?






21. From where do cytokines come from?






22. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






23. what cell surface marker is used for NK cells as it is unique to them?






24. What does IL 5 do?






25. describe the classic complement pathway.






26. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






27. Which HLA's are included in MHC I? MHC II?

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28. What are the major functions of Antibodies?






29. What is the clinical use for azathioprine?






30. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






31. what results in symptoms of shock in an acute hemolytic transfusion reaction?






32. What does granulysin do?






33. What are the cell surface proteins for Macrophages? which two are for opsonins?






34. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






35. What are the autoantibodies for other vasculitides?






36. What is the pathogenesis of acute transplant rejection? When does it occur?






37. which antibody is involved in the primary response or immediate response to an antigen?






38. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






39. what characterizes an arthus reaction?






40. What is colostrum?






41. The ______ in the BM are DN - the DP are in the cortex of thymus






42. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






43. What is digoxin immune Fab used for?






44. What is three common causes of severe combined immunodef? What is the result of all three?






45. can igG cross the placenta?






46. What are the mediators that mast cells release?






47. What is muromonab - CD3 (OKT3)






48. other than C3a - what other complement acts as an anaphyloxin?






49. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






50. To what disease do the autoantibodies to IgG (rheumatoid factor)?