Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are some sinopulmonary infections?






2. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






3. Describe the capsular structure of a lymph node; What are the functions of the LN?






4. A lymph node is a ________ lymphoid organ.






5. What do multimeric antibodies require for assembly?






6. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






7. IgM can exist as a _______ also






8. Which MHC presents intracellular peptides? how so?






9. Give an example of someone who could get hyperacute transplant rejection.






10. What is the clinical use for sirolimus? what should you combine it with?






11. What are the main cell surface proteins on B cells?






12. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






13. What are the two signals required for Th1 cells? what happens after then activated?






14. What does IL 4 do?






15. What lymph node drains the scrotum?






16. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






17. what cell surface marker is used for NK cells as it is unique to them?






18. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






19. which cytokine inhibits TH2 cells? secreted by who?






20. describe the pathogenesis of delayed type IV hypersensitivity






21. when can graft versus host disease? What is the result?






22. What are the two signals required for B cell class switching? Which is the second signal?






23. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






24. What are the autoantibodies for Mixed connective tissue disease?






25. What are the autoantibodies for systemic sclerosis?






26. What are the function of B cells?






27. What are the mediators that mast cells release?






28. what prevents NK cells from killing normal cells if their default is to kill?






29. where do somatic hypermutation and class switching occur?






30. From where do cytokines come from?






31. What are the autoantibodies for other vasculitides?






32. What are the autoantibodies for polymyositis and dermatomyositis?






33. What is the autoantibody for SLE that is nonspecific? Specific?






34. T/F B cells do not require a second signal






35. Which disease is associated with DR7?






36. Only the _______ contribute to the Fc region






37. How is sirolimus different from tacrolimus?






38. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






39. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






40. where do NK cells develop?






41. What is filgrastim and sargramostim? and What is it used for?






42. describe the classic complement pathway.






43. What is the pathogenesis of HyperIgE syndrome? What are the labs?






44. For which toxins are preformed antibodies (passive) given?






45. What does Interferon alpha and beta do? how?






46. Other than stimulating fever - what else does IL 6 do?






47. What is the main cytokine that activates eosinophils?






48. Which disease is associated with HLA A3?






49. What are the autoantibodies for Celiac disease?






50. What are the labs in brutons agammaglobulinemia?