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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what will NK cells do to cells covered in IgG Ab? why?






2. What are the autoantibodies for sjorgens syndrome?






3. What is the presentation of hyperIgM syndrome?






4. in which immunodef order do you see a lot of pus? no pus?






5. What are the autoantibodies for type I diabetes mellitus?






6. What does granzyme do? who secretes it?






7. What portion of the lymph node is not well developed in DiGeorge Syndrome?






8. What are the autoantibodies for other vasculitides?






9. What can cause a lymph node enlargement?






10. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






11. The alternative pathway is the only constutively...






12. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






13. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






14. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






15. The two heavy chains of an antibody contribute to the...






16. What is the pathogenesis of a hypersensitivity reaction?






17. What is the toxicity of azathioprine?






18. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






19. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






20. What is the defect in hyper IgM syndrome? What are the lab results?






21. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






22. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






23. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






24. can igG cross the placenta?






25. How is the thymus organized? what happens in each section?






26. Which helper T cells' development is induced by IL 4? IL 12?






27. The secondary follicles have __________; primary follicles are dense






28. What are the cell surface proteins for Macrophages? which two are for opsonins?






29. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






30. What is the main function of IL 12? other than macrophages who else can release IL 12?






31. What lymph node drains the testes?






32. To what disease do the autoantibodies to IgG (rheumatoid factor)?






33. What are the autoantibodies for autoimmune hepatitis?






34. What lymph node drains the sigmoid colon?






35. Describe the capsular structure of a lymph node; What are the functions of the LN?






36. is IgM an opsonizer?






37. Which disease is associated with DR7?






38. What is the clinical use of Muromonab?






39. What are the labs in brutons agammaglobulinemia?






40. hat is the presentation of Jobs syndrome or Hyper IgE?






41. what results in symptoms of shock in an acute hemolytic transfusion reaction?






42. What is the clinical use for sirolimus? what should you combine it with?






43. What is the most common example of passive immunity?






44. What is a factor that is a predictor for a bad transplantation?






45. What are the cell surface proteins on NK cells?






46. How does the alternative pathway lead to MAC activation?






47. What lymph node drains the lateral side of the dorsum of the foot?






48. What does it mean if there are igM in the serum at birth?






49. What is the toxicity of muromonab?






50. What are the two signals to kill for NK cells?