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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what ensure that a memory response is generated?






2. which cells have more complete tolerance - B or T cells?






3. are Th cells involved in trapping of antigens of endotoxin/LPS?






4. What is the toxicity of muromonab?






5. What is epo used for?






6. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






7. Which cytokines do Th2 release and For what?






8. Which MHC presents intracellular peptides? how so?






9. What are the function of B cells?






10. Which diseases are associated with DR5?






11. IgM can fix complement but...






12. From where do cytokines come from?






13. What is the main cytokine that activates eosinophils?






14. What are the autoantibodies for goodpastures syndrome?






15. What is the main function of IL 12? other than macrophages who else can release IL 12?






16. What lymph node drains the scrotum?






17. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






18. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






19. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






20. What is the defect in hyper IgM syndrome? What are the lab results?






21. How does complement link innate and adaptive?






22. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






23. What is the general structure of an Ab?






24. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






25. What does interferon gamma do? What two type of cells does it attack mostly?






26. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






27. Describe the complement independent Type II hypersenstivity reaction. Give an example.






28. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






29. What are the autoantibodies for primary biliary cirrhosis?






30. What is the receptor for EBV? On what cells is that located?






31. What is recomb gamma interferon used for?






32. What does granzyme do? who secretes it?






33. What is the main function of TNF alpha? How does it do this?






34. IgM can exist as a _______ also






35. What is the presentation of common variable immunodef? and What are the labs?






36. What is three common causes of severe combined immunodef? What is the result of all three?






37. What are some catalase positive organisms?






38. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






39. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






40. To what portion of the Antibody do the complements bind?






41. What portion of the lymph node is not well developed in DiGeorge Syndrome?






42. The pathogenesis of contact dermatitis is ________ hypersensitivity






43. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






44. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






45. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






46. is IgM an opsonizer?






47. What is the most common selective Ig deficiency? What is the presentation?






48. where do somatic hypermutation and class switching occur?






49. What are the autoantibodies for graves?






50. What is the pathogenesis of a candida skin test?







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