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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. IgM can fix complement but...






2. which antibodies can bind complement?






3. Which is the main antibody in the delayed or secondary response to an antigen?






4. Which diseases are associated with DR5?






5. What are the two signals required for T cells? what happens after?






6. What are the labs in brutons agammaglobulinemia?






7. What do mature naive B lymphocytes express?






8. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






9. What are the autoantibodies for Celiac disease?






10. What is the main cytokine that activates eosinophils?






11. Complements are...






12. To what portion of the Antibody do the complements bind?






13. What is the main cytokine released by T cells? What does it do






14. What is the pathology of acute transplant rejection? is it reversible?






15. What are some catalase positive organisms?






16. What are the function of B cells?






17. What is the pathogenesis of a candida skin test?






18. Leukocyte adhesion defect presents with...






19. What is the main function of IL 8?






20. In general What are T cells good for?






21. What are superantigens? give two examples.






22. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






23. What does IL 10 do? who is secreted by?






24. What are the autoantibodies for myasthenia gravis?






25. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






26. What lymph node drains the duodenum - jejunum?






27. What is the mechanism for sirolimus? what else it known as?






28. What are the autoantibodies for systemic sclerosis?






29. The Fc region is found on the...






30. How is sirolimus different from tacrolimus?






31. What lymph node drains the scrotum?






32. What are the autoantibodies for graves?






33. Which disease is associated withB B27?






34. What does IL 5 do?






35. What is epo used for?






36. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






37. What is chronic mucocutaneous candidiasis d/t?






38. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






39. What is the treatment of acute transplant rejection?






40. What is the pathogenesis of HyperIgE syndrome? What are the labs?






41. What are the main cell surface proteins on B cells?






42. What is a factor that is a predictor for a bad transplantation?






43. What is recomb gamma interferon used for?






44. What cytokines are released by Th1 cells?






45. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






46. How does igA cross the epithelium?






47. What are the autoantibodies for pemphigus bulgaris?






48. What is the cause of thymic aplasia? What is its presentation? What are the labs?






49. The MALT/GALT are not...






50. which interleukin receptor is required for NK development? activation?







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