Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






2. Leukocyte adhesion defect presents with...






3. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






4. hat is the presentation of Jobs syndrome or Hyper IgE?






5. What is the presentation of hyperIgM syndrome?






6. What are the major functions of Antibodies?






7. what bacteria are a splenectomy patient most susceptible to? why?






8. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






9. which of the hypersensitivity reactions is not Ab mediated?






10. which cytokine inhibits TH2 cells? secreted by who?






11. Which type of selection of thymic development provides central tolerance?






12. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






13. What are the autoantibodies for goodpastures syndrome?






14. What cytokines to Th2 secrete?






15. How does the alternative pathway lead to MAC activation?






16. What is the cause of thymic aplasia? What is its presentation? What are the labs?






17. How is i Th1 helper cell inhibited?






18. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






19. What is the main cytokine released by T cells? What does it do






20. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






21. Which disease is associated with B8?






22. What is epo used for?






23. what secretes IL 4?






24. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






25. What do multimeric antibodies require for assembly?






26. when can graft versus host disease? What is the result?






27. Describe complement dependent Type II hypersensitivity. Give an example.






28. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






29. The MALT/GALT are not...






30. What is recomb beta interferon used for?






31. What is a type I hypersensitivity reaction? What is atopic?






32. How does complement link innate and adaptive?






33. Which cytokines do Th2 release and For what?






34. The lymphocytes are ________ origin






35. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






36. Which antibody mediates immunity to worms? how?






37. describe the pathogenesis of delayed type IV hypersensitivity






38. What is an example of a parasite showing antigenic variation?






39. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






40. IgE has the ___________ in the serum






41. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






42. What are the mediators that mast cells release?






43. What are the autoantibodies for pemphigus bulgaris?






44. What are the autoantibodies for pernicious anemia?






45. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






46. What are the autoantibodies for myasthenia gravis?






47. What are the main cell surface proteins on B cells?






48. what will NK cells do to cells covered in IgG Ab? why?






49. What are the T cell functions?






50. What is the pathogenesis of HyperIgE syndrome? What are the labs?