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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. To what portion of the Antibody do the complements bind?






2. What is the common variable immunodeficiency ? How is it different from Brutons?






3. What is the general structure of an Ab?






4. What are the symptoms of serum sickness?






5. What does IL 10 do? who is secreted by?






6. What are four results of a splenectomy?






7. What is colostrum?






8. when can graft versus host disease? What is the result?






9. What are the autoantibodies for pemphigus bulgaris?






10. What is muromonab - CD3 (OKT3)






11. What are the autoantibodies for pernicious anemia?






12. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






13. other than C3a - what other complement acts as an anaphyloxin?






14. Give an example of someone who could get hyperacute transplant rejection.






15. What lymph node drains the rectum (above the pectinate line)?






16. What is the most common example of passive immunity?






17. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






18. which of the hypersensitivity reactions is not Ab mediated?






19. can igG cross the placenta?






20. What is the cause of thymic aplasia? What is its presentation? What are the labs?






21. Which disease is associated with DR7?






22. How do you test for chronic granulomatous disease?






23. How is i Th1 helper cell inhibited?






24. Leukocyte adhesion defect presents with...






25. What is the late phase reaction of anaphylaxis allergy? what mediates it?






26. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






27. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






28. What are the autoantibodies for primary biliary cirrhosis?






29. What type of side chains are found on Fc region of an antibody?






30. which of the transplant rejections is antibody mediated? why does it occur?






31. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






32. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






33. What does interferon gamma do to be antiviral?






34. What are the two signals required for B cell class switching? Which is the second signal?






35. What is digoxin immune Fab used for?






36. What is the pathogenesis of a hypersensitivity reaction?






37. What are howell jolly bodies?






38. What is the pathogenesis of acute transplant rejection? When does it occur?






39. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






40. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






41. What are the autoantibodies for goodpastures syndrome?






42. Which are the only two antiinflammatory cytokines?






43. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






44. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






45. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






46. The idiotype; the Fc portion determines the...






47. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






48. Which is the main antibody that provides passive immunity to infants?






49. what cell surface proteins are on all APCs?






50. What are the two signals required for Th1 cells? what happens after then activated?







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