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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the clinical use for azathioprine?






2. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






3. What is the defect in hyper IgM syndrome? What are the lab results?






4. What are the cell surface proteins for Macrophages? which two are for opsonins?






5. In general What are T cells good for?






6. What are target cells?






7. What cytokines to Th2 secrete?






8. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






9. The MALT/GALT are not...






10. What is the main cytokine released by T cells? What does it do






11. What is the pathogenesis of acute transplant rejection? When does it occur?






12. What is the toxicity of muromonab?






13. What is the main cytokine that activates eosinophils?






14. What is the mechanism for sirolimus? what else it known as?






15. What lymph node drains the upper limb?






16. What is recomb gamma interferon used for?






17. What are four results of a splenectomy?






18. can igG cross the placenta?






19. How does complement link innate and adaptive?






20. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






21. What do mature naive B lymphocytes express?






22. Describe the Mannose Lectin pathway






23. What are the main symptoms of B cell immunodeficiencies?






24. What are the autoantibodies for Celiac disease?






25. What happens in a deficiency of C3?






26. What is the pathology of acute transplant rejection? is it reversible?






27. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






28. what cytokine does basophils secrete?






29. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






30. IgE has the ___________ in the serum






31. What is recomb alpha interferon used for?






32. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






33. which cells have more complete tolerance - B or T cells?






34. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






35. What are the PALS?






36. What lymph node drains the breast?






37. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






38. What is epo used for?






39. What are superantigens? give two examples.






40. The Fc region is found on the...






41. are Th cells involved in trapping of antigens of endotoxin/LPS?






42. give an example of how influenza does a major antigenic shift.






43. How do you test for type III hypersensitivity?






44. What is the presentation of scid? treatment?






45. describe the pathogenesis of delayed type IV hypersensitivity






46. How is sirolimus different from tacrolimus?






47. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






48. What are the main symptoms of T cell immunodeficiencies?






49. Which diseases are associated with DR4?






50. What does IL 4 do?