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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Give an example of someone who could get hyperacute transplant rejection.






2. IgM can fix complement but...






3. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






4. describe the classic complement pathway.






5. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






6. The two heavy chains of an antibody contribute to the...






7. What is the marginal zone of the spleen? what happens there?






8. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






9. How does complement link innate and adaptive?






10. What is the presentation of Brutons agammaglobulinemia?






11. What are the autoantibodies for Celiac disease?






12. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






13. What lymph node drains the breast?






14. What are the cell surface proteins for Macrophages? which two are for opsonins?






15. What is the main cytokine released by T cells? What does it do






16. What lymph node drains the lateral side of the dorsum of the foot?






17. what cell surface proteins are on all APCs?






18. What is the pathogenesis of a hypersensitivity reaction?






19. What are the main Cell surface proteins on T cells?






20. What is the main function of TNF alpha? How does it do this?






21. What is recomb alpha interferon used for?






22. Which diseases are associated with DR4?






23. what prevents NK cells from killing normal cells if their default is to kill?






24. What is the pathology of acute transplant rejection? is it reversible?






25. which cells have more complete tolerance - B or T cells?






26. What is the presentation of hyperIgM syndrome?






27. is IgM an opsonizer?






28. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






29. What does granzyme do? who secretes it?






30. In general What are T cells good for?






31. Which HLA's are included in MHC I? MHC II?

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32. What is serum sickness? give an example.






33. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






34. What is the pathology in hyperacute transplant rejection?






35. What does granulysin do?






36. A lymph node is a ________ lymphoid organ.






37. To what portion of the Antibody do the complements bind?






38. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






39. What does it mean if there are igM in the serum at birth?






40. What are the autoantibodies for goodpastures syndrome?






41. What type of side chains are found on Fc region of an antibody?






42. Which MHC presents intracellular peptides? how so?






43. which of the transplant rejections is antibody mediated? why does it occur?






44. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






45. What is digoxin immune Fab used for?






46. Which disease is associated withB B27?






47. where do NK cells develop?






48. Which is the main antibody that provides passive immunity to infants?






49. which type of immunity is slow but long lasting? as opposed to...






50. what will NK cells do to cells covered in IgG Ab? why?