Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is a factor that is a predictor for a bad transplantation?






2. What are the three types of lymphocytes?






3. what results in symptoms of shock in an acute hemolytic transfusion reaction?






4. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






5. So antibodies are the effectors for the humoral response. List some of their functions.






6. which of the hypersensitivity reactions is not Ab mediated?






7. What does IL 2 do?






8. What is colostrum?






9. What is a type I hypersensitivity reaction? What is atopic?






10. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






11. Which is the most abundant antibody in blood?






12. What is oprelevkin? and What is it used for?






13. Only the _______ contribute to the Fc region






14. what ensure that a memory response is generated?






15. What kinds of receptors activate innate immunity?






16. Which disease is associated withB B27?






17. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






18. What is the defect in hyper IgM syndrome? What are the lab results?






19. What are the autoantibodies for type I diabetes mellitus?






20. other than C3a - what other complement acts as an anaphyloxin?






21. What are the autoantibodies for autoimmune hepatitis?






22. which antibodies can bind complement?






23. What does granzyme do? who secretes it?






24. What are the autoantibodies for wegeners granulomatosis?






25. IgM can fix complement but...






26. What is the common variable immunodeficiency ? How is it different from Brutons?






27. What is the clinical use for azathioprine?






28. What are superantigens? give two examples.






29. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






30. What are the autoantibodies for pemphigus bulgaris?






31. hat is the presentation of Jobs syndrome or Hyper IgE?






32. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






33. What are the T cell functions?






34. What are the autoantibodies for Mixed connective tissue disease?






35. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






36. What are the autoantibodies for polymyositis and dermatomyositis?






37. what will NK cells do to cells covered in IgG Ab? why?






38. What portion of the lymph node is not well developed in DiGeorge Syndrome?






39. IgM can exist as a _______ also






40. which of the transplant rejections is antibody mediated? why does it occur?






41. From where do cytokines come from?






42. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






43. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






44. What is the clinical use for sirolimus? what should you combine it with?






45. What do mature naive B lymphocytes express?






46. The two heavy chains of an antibody contribute to the...






47. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






48. What are the autoantibodies for pernicious anemia?






49. How does igA cross the epithelium?






50. What are some sinopulmonary infections?