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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. IgM can exist as a _______ also






2. Which diseases are associated with DR5?






3. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






4. is IgM an opsonizer?






5. Give three examples of bacteria that use antigenic variation and how.






6. IgG...






7. The MALT/GALT are not...






8. What type of fenestrations are found in the red pulp of the spleen?






9. which antibodies prevent antigens from binding mucosal surfaces?






10. What links the adaptive and innate immunity?






11. What are howell jolly bodies?






12. What are the autoantibodies for pemphigus bulgaris?






13. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






14. which of the transplant rejections is antibody mediated? why does it occur?






15. IgM can fix complement but...






16. What is an example of a parasite showing antigenic variation?






17. How do you test for chronic granulomatous disease?






18. what bacteria are a splenectomy patient most susceptible to? why?






19. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






20. What is the defect in hyper IgM syndrome? What are the lab results?






21. Leukocyte adhesion defect presents with...






22. What is the marginal zone of the spleen? what happens there?






23. What type of side chains are found on Fc region of an antibody?






24. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






25. What is thrombopoietin used for?






26. How does igA cross the epithelium?






27. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






28. What is the mechanism for sirolimus? what else it known as?






29. describe the classic complement pathway.






30. What lymph node drains the anal canal (below the pectinate line)?






31. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






32. What is the clinical use of Muromonab?






33. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






34. which antibodies can bind complement?






35. What are the two signals required for T cells? what happens after?






36. what results in symptoms of shock in an acute hemolytic transfusion reaction?






37. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






38. Name two endogenous pyrogens






39. What is recomb alpha interferon used for?






40. In thymic development - What is the positive selection? negative selections?






41. What is the main cytokine that activates eosinophils?






42. What does Interferon alpha and beta do? how?






43. The pathogenesis of contact dermatitis is ________ hypersensitivity






44. Type IV hypersensitivity is i...






45. What is the pathology in hyperacute transplant rejection?






46. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






47. What is the pathology of acute transplant rejection? is it reversible?






48. For which toxins are preformed antibodies (passive) given?






49. What are the autoantibodies for graves?






50. To what portion of the Antibody do the complements bind?







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