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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what results in symptoms of shock in an acute hemolytic transfusion reaction?






2. The idiotype; the Fc portion determines the...






3. Type Iv hypersensitivity is...






4. What does it mean if there are igM in the serum at birth?






5. Which disease is associated with B8?






6. What is anergy? why does this occur?






7. What is the autoantibody for SLE that is nonspecific? Specific?






8. Which cytokines do Th2 release and For what?






9. What is Aldesleukin? What is it used for






10. What is the toxicity of azathioprine?






11. What is the main function of TNF alpha? How does it do this?






12. What does Interferon alpha and beta do? how?






13. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






14. What is muromonab - CD3 (OKT3)






15. What lymph node drains the thigh?






16. Which disease is associated withB B27?






17. What is the presentation of scid? treatment?






18. What are the three types of APCs?






19. What is the most common example of passive immunity?






20. How does complement link innate and adaptive?






21. The ______ in the BM are DN - the DP are in the cortex of thymus






22. What lymph node drains the scrotum?






23. What is the main function of IL 12? other than macrophages who else can release IL 12?






24. IgM can fix complement but...






25. What bugs can actually infect the lymph node itself?






26. What are the autoantibodies for polymyositis and dermatomyositis?






27. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






28. What are the autoantibodies for drug induced lupus?






29. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






30. give an example of how influenza does a major antigenic shift.






31. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






32. Give an example of someone who could get hyperacute transplant rejection.






33. What is oprelevkin? and What is it used for?






34. How fast does it occur?






35. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






36. What is the white pulp of the spleen?






37. What does interferon gamma do? What two type of cells does it attack mostly?






38. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






39. Describe complement dependent Type II hypersensitivity. Give an example.






40. What is the clinical use of Muromonab?






41. Which is the most abundant antibody in blood?






42. What are the two signals required for T cells? what happens after?






43. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






44. What does IgA pick up from epithelial cells before being secreted?






45. What are the autoantibodies for type I diabetes mellitus?






46. what cell surface proteins are on all APCs?






47. What is passive immunity?






48. What are the autoantibodies for graves?






49. What are the main cell surface proteins on B cells?






50. What is the receptor for EBV? On what cells is that located?