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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. when can graft versus host disease? What is the result?






2. What is immune complex disease? give an example.






3. What does it mean if there are igM in the serum at birth?






4. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






5. Name 5 ways Antibody diversity is generated?






6. What are the main Cell surface proteins on T cells?






7. IgG...






8. which cells have more complete tolerance - B or T cells?






9. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






10. To what disease do the autoantibodies to IgG (rheumatoid factor)?






11. What is recomb alpha interferon used for?






12. What is an example of a parasite showing antigenic variation?






13. other than C3a - what other complement acts as an anaphyloxin?






14. What is the marginal zone of the spleen? what happens there?






15. What is the clinical use of Muromonab?






16. How do you test for type III hypersensitivity?






17. From where do cytokines come from?






18. Give three examples of bacteria that use antigenic variation and how.






19. which antibodies can bind complement?






20. what ensure that a memory response is generated?






21. other than mediating shock - what else does TNF alpha do? who releases it mainly?






22. Which disease is associated with DR3?






23. What is recomb gamma interferon used for?






24. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






25. What is the clinical use for azathioprine?






26. Leukocyte adhesion defect presents with...






27. What lymph node drains the lateral side of the dorsum of the foot?






28. What is the white pulp of the spleen?






29. How fast does it occur?






30. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






31. which type of immunity is slow but long lasting? as opposed to...






32. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






33. What are the mediators that mast cells release?






34. How do you test for chronic granulomatous disease?






35. What lymph node drains the scrotum?






36. which interleukin receptor is required for NK development? activation?






37. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






38. Give an example of someone who could get hyperacute transplant rejection.






39. The ______ in the BM are DN - the DP are in the cortex of thymus






40. What happens in a deficiency of C3?






41. describe the classic complement pathway.






42. What is the pathology in hyperacute transplant rejection?






43. what cell surface marker is used for NK cells as it is unique to them?






44. in which immunodef order do you see a lot of pus? no pus?






45. What are the autoantibodies for graves?






46. what secretes IL 4?






47. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






48. which of the transplant rejections is antibody mediated? why does it occur?






49. What are the main cell surface proteins on B cells?






50. What is oprelevkin? and What is it used for?







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