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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the pathogenesis of HyperIgE syndrome? What are the labs?






2. other than eat and bite RBCs what else do Macrophages of spleen do>






3. Describe the complement independent Type II hypersenstivity reaction. Give an example.






4. What does IL 4 do?






5. What are the autoantibodies for type I diabetes mellitus?






6. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






7. From where do cytokines come from?






8. What links the adaptive and innate immunity?






9. What is immune complex disease? give an example.






10. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






11. What does interferon gamma do? What two type of cells does it attack mostly?






12. What do mature naive B lymphocytes express?






13. What is anergy? why does this occur?






14. can igG cross the placenta?






15. What is the main cytokine that activates eosinophils?






16. which B and T cell disorder presents with specifically low IgM?






17. What is the autoantibody for SLE that is nonspecific? Specific?






18. Describe the capsular structure of a lymph node; What are the functions of the LN?






19. What are the two signals required for Th1 cells? what happens after then activated?






20. The ______ in the BM are DN - the DP are in the cortex of thymus






21. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






22. which antibodies prevent antigens from binding mucosal surfaces?






23. What are the main Cell surface proteins on T cells?






24. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






25. What does interferon gamma do to be antiviral?






26. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






27. The two heavy chains of an antibody contribute to the...






28. What can cause a lymph node enlargement?






29. How do you test for chronic granulomatous disease?






30. What is passive immunity?






31. What is the clinical use for azathioprine?






32. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






33. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






34. what results in symptoms of shock in an acute hemolytic transfusion reaction?






35. Which is the main antibody that provides passive immunity to infants?






36. What are the autoantibodies for Celiac disease?






37. where are complements produced?






38. Which cytokines do Th2 release and For what?






39. How is the thymus organized? what happens in each section?






40. What does granulysin do?






41. What lymph node drains the lateral side of the dorsum of the foot?






42. What is the pathogenesis of acute transplant rejection? When does it occur?






43. where do NK cells develop?






44. What is chronic mucocutaneous candidiasis d/t?






45. what characterizes an arthus reaction?






46. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






47. in which immunodef order do you see a lot of pus? no pus?






48. What happens in a secondary follicle?






49. What is the pathology of acute transplant rejection? is it reversible?






50. Which type of selection of thymic development provides central tolerance?







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