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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what mediates the type II hypersensitivity? What are the two different methods?

2. which of the transplant rejections is antibody mediated? why does it occur?

3. hat is the presentation of Jobs syndrome or Hyper IgE?

4. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.

5. Other than stimulating fever - what else does IL 6 do?

6. Which disease is associated with HLA A3?

7. What is the main function of interferons?

8. What is hereditary angioedema? What are the C3 levels?

9. What are the autoantibodies for type I diabetes mellitus?

10. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>

11. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?

12. What is filgrastim and sargramostim? and What is it used for?

13. The idiotype; the Fc portion determines the...

14. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?

15. What are the three types of lymphocytes?

16. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?

17. What is the pathogenesis of HyperIgE syndrome? What are the labs?

18. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?

19. Name the three opsonins

20. what cytokine does basophils secrete?

21. What type of side chains are found on Fc region of an antibody?

22. What happens in a deficiency of C3?

23. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?

24. What is the white pulp of the spleen?

25. What does granzyme do? who secretes it?

26. what cell surface marker is used for NK cells as it is unique to them?

27. What is the pathogenesis of a candida skin test?

28. What is a type I hypersensitivity reaction? What is atopic?

29. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?

30. what will NK cells do to cells covered in IgG Ab? why?

31. what cell surface proteins are on all APCs?

32. What cytokines to Th2 secrete?

33. What is the main cytokine that activates eosinophils?

34. What is the most common selective Ig deficiency? What is the presentation?

35. What is digoxin immune Fab used for?

36. What is the cause of thymic aplasia? What is its presentation? What are the labs?

37. Describe complement dependent Type II hypersensitivity. Give an example.

38. What are MHC's necessary for? By themselves?

39. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?

40. What are the PALS?

41. What are the main cell surface proteins on B cells?

42. What are the autoantibodies for drug induced lupus?

43. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?

44. What is the presentation of scid? treatment?

45. The alternative pathway is the only constutively...

46. where are complements produced?

47. What is recomb beta interferon used for?

48. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?

49. which antibodies can bind complement?

50. What does IL 5 do?