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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. where do NK cells develop?






2. What is the main cytokine released by T cells? What does it do






3. What is the receptor for EBV? On what cells is that located?






4. What are target cells?






5. What is the pathology in hyperacute transplant rejection?






6. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






7. Which disease is associated with B8?






8. Which HLA's are included in MHC I? MHC II?

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9. Which antibodies can be multimeric?






10. Which is the main antibody in the delayed or secondary response to an antigen?






11. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






12. How do you test for chronic granulomatous disease?






13. What is the pathogenesis of a hypersensitivity reaction?






14. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






15. What kinds of receptors activate innate immunity?






16. What are the three types of lymphocytes?






17. In general What are T cells good for?






18. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






19. How does igA cross the epithelium?






20. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






21. Monomer in circulation - ___ when secreted






22. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






23. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






24. What lymph node drains the breast?






25. What lymph node drains the duodenum - jejunum?






26. What type of fenestrations are found in the red pulp of the spleen?






27. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






28. which cells have more complete tolerance - B or T cells?






29. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






30. What is the pathogenesis of acute transplant rejection? When does it occur?






31. other than C3a - what other complement acts as an anaphyloxin?






32. What is the presentation of common variable immunodef? and What are the labs?






33. What are the autoantibodies for myasthenia gravis?






34. What is recomb alpha interferon used for?






35. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






36. IgG...






37. What is the clinical use for sirolimus? what should you combine it with?






38. What is hereditary angioedema? What are the C3 levels?






39. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






40. What are the two signals required for Th1 cells? what happens after then activated?






41. What is the main function of interferons?






42. What are the autoantibodies for other vasculitides?






43. What are the autoantibodies for graves?






44. Which cytokines do Th2 release and For what?






45. ________ regulate the cell mediated response.






46. Give three examples of bacteria that use antigenic variation and how.






47. Which diseases are associated with DR5?






48. What is the most common example of passive immunity?






49. what cell surface marker is used for NK cells as it is unique to them?






50. Which is the main antibody that provides passive immunity to infants?







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