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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for systemic sclerosis?






2. What do mature naive B lymphocytes express?






3. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






4. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






5. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






6. what will NK cells do to cells covered in IgG Ab? why?






7. What is the pathogenesis of a hypersensitivity reaction?






8. What are the autoantibodies for Mixed connective tissue disease?






9. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






10. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






11. What cytokines to Th2 secrete?






12. Which are the only two antiinflammatory cytokines?






13. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






14. Which diseases are associated with DR5?






15. What is a type I hypersensitivity reaction? What is atopic?






16. How is the thymus organized? what happens in each section?






17. What lymph node drains the testes?






18. What is passive immunity?






19. To what portion of the Antibody do the complements bind?






20. What type of side chains are found on Fc region of an antibody?






21. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






22. What is the cause of thymic aplasia? What is its presentation? What are the labs?






23. What is the mechanism for sirolimus? what else it known as?






24. What is the toxicity of azathioprine?






25. What is filgrastim and sargramostim? and What is it used for?






26. What is the pathology of acute transplant rejection? is it reversible?






27. What is the presentation of hyperIgM syndrome?






28. What is the late phase reaction of anaphylaxis allergy? what mediates it?






29. What lymph node drains the upper limb?






30. For which toxins are preformed antibodies (passive) given?






31. where do somatic hypermutation and class switching occur?






32. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






33. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






34. What is the defect in hyper IgM syndrome? What are the lab results?






35. What are the autoantibodies for type I diabetes mellitus?






36. describe the pathogenesis of delayed type IV hypersensitivity






37. Which is the main antibody in the delayed or secondary response to an antigen?






38. What are some catalase positive organisms?






39. What is the main cytokine released by T cells? What does it do






40. What lymph node drains the anal canal (below the pectinate line)?






41. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






42. What are the main symptoms of T cell immunodeficiencies?






43. What are C1 - C2 - C3 - C4 important for?






44. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






45. In thymic development - What is the positive selection? negative selections?






46. What does IL 10 do? who is secreted by?






47. Which disease is associated with B8?






48. IgG...






49. other than C3a - what other complement acts as an anaphyloxin?






50. What is the most common example of passive immunity?







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