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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Type IV hypersensitivity is i...

2. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?

3. What is colostrum?

4. What does IL 4 do?

5. What are the autoantibodies for hashimotos?

6. What are the symptoms of serum sickness?

7. Which disease is associated withB B27?

8. What is the pathology of acute transplant rejection? is it reversible?

9. From where do cytokines come from?

10. Which disease is associated with HLA A3?

11. What are howell jolly bodies?

12. IgM can exist as a _______ also

13. What is the presentation of common variable immunodef? and What are the labs?

14. What are some catalase positive organisms?

15. which type of immunity is slow but long lasting? as opposed to...

16. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?

17. Name the three opsonins

18. What are the two signals required for T cells? what happens after?

19. which of the transplant rejections is antibody mediated? why does it occur?

20. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?

21. What is the pathogenesis of a candida skin test?

22. What does granzyme do? who secretes it?

23. ________ regulate the cell mediated response.

24. The pathogenesis of contact dermatitis is ________ hypersensitivity

25. Describe the Mannose Lectin pathway

26. What happens in a secondary follicle?

27. The idiotype; the Fc portion determines the...

28. What is the white pulp of the spleen?

29. What is the most common example of passive immunity?

30. Monomer in circulation - ___ when secreted

31. are Th cells involved in trapping of antigens of endotoxin/LPS?

32. What is the main cytokine that activates eosinophils?

33. What does IL 2 do?

34. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?

35. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?

36. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?

37. which interleukin receptor is required for NK development? activation?

38. which cytokine inhibits TH2 cells? secreted by who?

39. Which are the only two antiinflammatory cytokines?

40. What is Aldesleukin? What is it used for

41. describe the classic complement pathway.

42. What do multimeric antibodies require for assembly?

43. What lymph node drains the sigmoid colon?

44. Describe complement dependent Type II hypersensitivity. Give an example.

45. What lymph node drains the stomach?

46. What are superantigens? give two examples.

47. Which disease is associated with DR7?

48. What is the cause of thymic aplasia? What is its presentation? What are the labs?

49. Which antibody mediates immunity to worms? how?

50. what bacteria are a splenectomy patient most susceptible to? why?