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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






2. What do multimeric antibodies require for assembly?






3. What type of side chains are found on Fc region of an antibody?






4. Give three examples of bacteria that use antigenic variation and how.






5. In thymic development - What is the positive selection? negative selections?






6. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






7. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






8. What lymph node drains the rectum (above the pectinate line)?






9. What are the autoantibodies for hashimotos?






10. which antibodies prevent antigens from binding mucosal surfaces?






11. What are the major functions of Antibodies?






12. What is the toxicity of azathioprine?






13. when can graft versus host disease? What is the result?






14. What is the most common example of passive immunity?






15. What is thrombopoietin used for?






16. What are the autoantibodies for myasthenia gravis?






17. where are complements produced?






18. The Fc region is found on the...






19. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






20. The ______ in the BM are DN - the DP are in the cortex of thymus






21. Which disease is associated with DR7?






22. What does IL 5 do?






23. which type of immunity is slow but long lasting? as opposed to...






24. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






25. What is the main function of IL 12? other than macrophages who else can release IL 12?






26. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






27. What lymph node drains the upper limb?






28. which of the hypersensitivity reactions is not Ab mediated?






29. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






30. What lymph node drains the stomach?






31. Type Iv hypersensitivity is...






32. What does Interferon alpha and beta do? how?






33. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






34. What does IgA pick up from epithelial cells before being secreted?






35. What are the function of B cells?






36. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






37. How do you test for type III hypersensitivity?






38. What lymph node drains the sigmoid colon?






39. The alternative pathway is the only constutively...






40. Which is the most abundant antibody in blood?






41. What are the autoantibodies for Mixed connective tissue disease?






42. What cytokines to Th2 secrete?






43. What is the general structure of an Ab?






44. where do somatic hypermutation and class switching occur?






45. The lymphocytes are ________ origin






46. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






47. What is the autoantibody for SLE that is nonspecific? Specific?






48. What is oprelevkin? and What is it used for?






49. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






50. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?