Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the three types of APCs?






2. What is the most common selective Ig deficiency? What is the presentation?






3. What does granzyme do? who secretes it?






4. What is the defect in hyper IgM syndrome? What are the lab results?






5. What is muromonab - CD3 (OKT3)






6. How fast does it occur?






7. What is digoxin immune Fab used for?






8. What lymph node drains the lateral side of the dorsum of the foot?






9. where do somatic hypermutation and class switching occur?






10. How does complement link innate and adaptive?






11. What is the general structure of an Ab?






12. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






13. What are C1 - C2 - C3 - C4 important for?






14. What does IL 5 do?






15. What lymph node drains the breast?






16. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






17. which of the hypersensitivity reactions is not Ab mediated?






18. What are the autoantibodies for pernicious anemia?






19. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






20. What are the autoantibodies for systemic sclerosis?






21. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






22. Other than stimulating fever - what else does IL 6 do?






23. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






24. other than eat and bite RBCs what else do Macrophages of spleen do>






25. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






26. From where do cytokines come from?






27. What are the main Cell surface proteins on T cells?






28. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






29. What links the adaptive and innate immunity?






30. Type Iv hypersensitivity is...






31. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






32. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






33. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






34. What is the most common example of passive immunity?






35. What is the clinical use of Muromonab?






36. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






37. what happens in a deficiency of C1 esterase inhibitor? DAF?






38. What happens in a secondary follicle?






39. What does Interferon alpha and beta do? how?






40. which antibodies can bind complement?






41. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






42. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






43. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






44. What lymph node drains the anal canal (below the pectinate line)?






45. What are some catalase positive organisms?






46. What are the autoantibodies for sjorgens syndrome?






47. What is filgrastim and sargramostim? and What is it used for?






48. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






49. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






50. Which is the most abundant antibody in blood?