Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






2. What is the main cytokine released by T cells? What does it do






3. What are the autoantibodies for graves?






4. Which is the main antibody that provides passive immunity to infants?






5. Type IV hypersensitivity is i...






6. What lymph node drains the stomach?






7. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






8. What are MHC's necessary for? By themselves?






9. What is chronic mucocutaneous candidiasis d/t?






10. In thymic development - What is the positive selection? negative selections?






11. What are the two signals required for Th1 cells? what happens after then activated?






12. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






13. What are the autoantibodies for pernicious anemia?






14. where do somatic hypermutation and class switching occur?






15. What are the autoantibodies for polymyositis and dermatomyositis?






16. What is the common variable immunodeficiency ? How is it different from Brutons?






17. What are the two signals to kill for NK cells?






18. What is the pathogenesis of a hypersensitivity reaction?






19. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






20. What does granzyme do? who secretes it?






21. What does interferon gamma do? What two type of cells does it attack mostly?






22. What is the autoantibody for SLE that is nonspecific? Specific?






23. Describe the Mannose Lectin pathway






24. What bugs can actually infect the lymph node itself?






25. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






26. What is the late phase reaction of anaphylaxis allergy? what mediates it?






27. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






28. What are superantigens? give two examples.






29. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






30. what secretes IL 4?






31. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






32. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






33. What is the main function of IL 8?






34. The Fc region is found on the...






35. what mediates the type II hypersensitivity? What are the two different methods?






36. What are the autoantibodies for autoimmune hepatitis?






37. Which antibodies can be multimeric?






38. What are the main cell surface proteins on B cells?






39. in which immunodef order do you see a lot of pus? no pus?






40. What is the most common selective Ig deficiency? What is the presentation?






41. What are C1 - C2 - C3 - C4 important for?






42. What is a type I hypersensitivity reaction? What is atopic?






43. How does igA cross the epithelium?






44. In general What are T cells good for?






45. other than mediating shock - what else does TNF alpha do? who releases it mainly?






46. How do you test for type III hypersensitivity?






47. What is colostrum?






48. What are the autoantibodies for systemic sclerosis?






49. Name 5 ways Antibody diversity is generated?






50. What is the presentation of Brutons agammaglobulinemia?