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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the cell surface proteins for Macrophages? which two are for opsonins?






2. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






3. A lymph node is a ________ lymphoid organ.






4. Which disease is associated with HLA A3?






5. How is the thymus organized? what happens in each section?






6. How does complement link innate and adaptive?






7. What is digoxin immune Fab used for?






8. What does IL 2 do?






9. what happens in a deficiency of C1 esterase inhibitor? DAF?






10. What are the autoantibodies for polymyositis and dermatomyositis?






11. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






12. Which diseases are associated with DR4?






13. What bugs can actually infect the lymph node itself?






14. What are the autoantibodies for drug induced lupus?






15. Give three examples of bacteria that use antigenic variation and how.






16. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






17. what results in symptoms of shock in an acute hemolytic transfusion reaction?






18. What type of side chains are found on Fc region of an antibody?






19. What are superantigens? give two examples.






20. What is filgrastim and sargramostim? and What is it used for?






21. How is sirolimus different from tacrolimus?






22. What is serum sickness? give an example.






23. Name two endogenous pyrogens






24. What is the treatment of acute transplant rejection?






25. IgM can fix complement but...






26. What is the pathogenesis of a hypersensitivity reaction?






27. What are the autoantibodies for Mixed connective tissue disease?






28. What are the main symptoms of B cell immunodeficiencies?






29. What is the presentation of common variable immunodef? and What are the labs?






30. What is the main function of interferons?






31. What are the autoantibodies for hashimotos?






32. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






33. Which type of selection of thymic development provides central tolerance?






34. The alternative pathway is the only constutively...






35. What cytokines are released by Th1 cells?






36. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






37. IgE has the ___________ in the serum






38. What are the labs in brutons agammaglobulinemia?






39. What is recomb alpha interferon used for?






40. Which diseases are associated with DR5?






41. Which HLA's are included in MHC I? MHC II?

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42. What is the white pulp of the spleen?






43. The idiotype; the Fc portion determines the...






44. What is recomb gamma interferon used for?






45. What is the common variable immunodeficiency ? How is it different from Brutons?






46. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






47. what characterizes an arthus reaction?






48. other than eat and bite RBCs what else do Macrophages of spleen do>






49. What are the two signals to kill for NK cells?






50. What is the pathogenesis of a candida skin test?