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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the cell surface proteins on NK cells?






2. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






3. What are the function of B cells?






4. where are complements produced?






5. What are the mediators that mast cells release?






6. What are the autoantibodies for polymyositis and dermatomyositis?






7. what cell surface marker is used for NK cells as it is unique to them?






8. Describe complement dependent Type II hypersensitivity. Give an example.






9. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






10. What type of fenestrations are found in the red pulp of the spleen?






11. What is immune complex disease? give an example.






12. What is the pathology of acute transplant rejection? is it reversible?






13. What is the defect in hyper IgM syndrome? What are the lab results?






14. What is the common variable immunodeficiency ? How is it different from Brutons?






15. Describe the capsular structure of a lymph node; What are the functions of the LN?






16. What are the autoantibodies for pernicious anemia?






17. Which diseases are associated with DR2?






18. What is the clinical use for sirolimus? what should you combine it with?






19. What happens in a deficiency of C3?






20. The lymphocytes are ________ origin






21. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






22. What is the presentation of hyperIgM syndrome?






23. What is Aldesleukin? What is it used for






24. The alternative pathway is the only constutively...






25. Monomer in circulation - ___ when secreted






26. What is the main cytokine released by T cells? What does it do






27. How do you test for chronic granulomatous disease?






28. What are the autoantibodies for wegeners granulomatosis?






29. which cytokine inhibits TH2 cells? secreted by who?






30. What is chronic mucocutaneous candidiasis d/t?






31. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






32. Which is the main antibody in the delayed or secondary response to an antigen?






33. What do mature naive B lymphocytes express?






34. What are the two signals required for B cell class switching? Which is the second signal?






35. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






36. What is a type I hypersensitivity reaction? What is atopic?






37. Which antibodies can be multimeric?






38. can igG cross the placenta?






39. what bacteria are a splenectomy patient most susceptible to? why?






40. T/F B cells do not require a second signal






41. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






42. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






43. What can cause a lymph node enlargement?






44. What are the autoantibodies for primary biliary cirrhosis?






45. Other than stimulating fever - what else does IL 6 do?






46. What links the adaptive and innate immunity?






47. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






48. How is sirolimus different from tacrolimus?






49. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






50. Which helper T cells' development is induced by IL 4? IL 12?







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