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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. describe the pathogenesis of delayed type IV hypersensitivity






2. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






3. Type Iv hypersensitivity is...






4. Which disease is associated with DR3?






5. What does IL 4 do?






6. What are the autoantibodies for myasthenia gravis?






7. What is the white pulp of the spleen?






8. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






9. What is passive immunity?






10. The MALT/GALT are not...






11. What lymph node drains the upper limb?






12. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






13. What is the presentation of hyperIgM syndrome?






14. What lymph node drains the scrotum?






15. What are the main cell surface proteins on B cells?






16. Which disease is associated withB B27?






17. How do you test for chronic granulomatous disease?






18. which antibodies prevent antigens from binding mucosal surfaces?






19. Which helper T cells' development is induced by IL 4? IL 12?






20. where do NK cells develop?






21. What is oprelevkin? and What is it used for?






22. What is three common causes of severe combined immunodef? What is the result of all three?






23. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






24. The two heavy chains of an antibody contribute to the...






25. Other than stimulating fever - what else does IL 6 do?






26. What lymph node drains the anal canal (below the pectinate line)?






27. What are MHC's necessary for? By themselves?






28. What is the most common example of passive immunity?






29. What is the main function of IL 8?






30. What kinds of receptors activate innate immunity?






31. What are the autoantibodies for autoimmune hepatitis?






32. What type of side chains are found on Fc region of an antibody?






33. What are the autoantibodies for systemic sclerosis?






34. Which are the only two antiinflammatory cytokines?






35. What is the receptor for EBV? On what cells is that located?






36. What are the autoantibodies for hashimotos?






37. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






38. What are the autoantibodies for Celiac disease?






39. What is a type I hypersensitivity reaction? What is atopic?






40. What are four results of a splenectomy?






41. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






42. What are the autoantibodies for goodpastures syndrome?






43. what cell surface marker is used for NK cells as it is unique to them?






44. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






45. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






46. What are the T cell functions?






47. What is filgrastim and sargramostim? and What is it used for?






48. How is the thymus organized? what happens in each section?






49. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






50. What is an example of a parasite showing antigenic variation?