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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the thigh?






2. What is the pathology seen in chronic transplant rejection?






3. What are the T cell functions?






4. What is filgrastim and sargramostim? and What is it used for?






5. Which antibody mediates immunity to worms? how?






6. What is the treatment of acute transplant rejection?






7. Which disease is associated with DR3?






8. What are the cell surface proteins for Macrophages? which two are for opsonins?






9. Which is the main antibody that provides passive immunity to infants?






10. What are the cell surface proteins on NK cells?






11. What kinds of receptors activate innate immunity?






12. Complements are...






13. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






14. What can cause a lymph node enlargement?






15. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






16. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






17. How do you test for type III hypersensitivity?






18. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






19. What is the pathogenesis of a candida skin test?






20. Which type of selection of thymic development provides central tolerance?






21. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






22. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






23. what results in symptoms of shock in an acute hemolytic transfusion reaction?






24. What are MHC's necessary for? By themselves?






25. Describe the Mannose Lectin pathway






26. What type of fenestrations are found in the red pulp of the spleen?






27. The alternative pathway is the only constutively...






28. How do you test for chronic granulomatous disease?






29. Which diseases are associated with DR5?






30. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






31. What bugs can actually infect the lymph node itself?






32. T/F B cells do not require a second signal






33. What are the major functions of Antibodies?






34. For which toxins are preformed antibodies (passive) given?






35. What are the autoantibodies for wegeners granulomatosis?






36. Name the three opsonins






37. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






38. What does IL 4 do?






39. The pathogenesis of contact dermatitis is ________ hypersensitivity






40. What are the two signals required for Th1 cells? what happens after then activated?






41. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






42. What are the autoantibodies for other vasculitides?






43. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






44. What is the pathogenesis of acute transplant rejection? When does it occur?






45. The MALT/GALT are not...






46. Give an example of someone who could get hyperacute transplant rejection.






47. What lymph node drains the rectum (above the pectinate line)?






48. are Th cells involved in trapping of antigens of endotoxin/LPS?






49. What does IgA pick up from epithelial cells before being secreted?






50. What is muromonab - CD3 (OKT3)