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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






2. What happens in a deficiency of C3?






3. Which diseases are associated with DR5?






4. What are the two signals to kill for NK cells?






5. The alternative pathway is the only constutively...






6. what characterizes an arthus reaction?






7. What is an example of a parasite showing antigenic variation?






8. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






9. What is the marginal zone of the spleen? what happens there?






10. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






11. What is colostrum?






12. What are the autoantibodies for other vasculitides?






13. What are some catalase positive organisms?






14. What lymph node drains the anal canal (below the pectinate line)?






15. What do mature naive B lymphocytes express?






16. How is the thymus organized? what happens in each section?






17. What is the main function of IL 12? other than macrophages who else can release IL 12?






18. Type Iv hypersensitivity is...






19. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






20. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






21. Which diseases are associated with DR4?






22. What are target cells?






23. What are the autoantibodies for goodpastures syndrome?






24. What is three common causes of severe combined immunodef? What is the result of all three?






25. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






26. Monomer in circulation - ___ when secreted






27. Describe complement dependent Type II hypersensitivity. Give an example.






28. What does granulysin do?






29. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






30. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






31. What are the two signals required for B cell class switching? Which is the second signal?






32. What is the common variable immunodeficiency ? How is it different from Brutons?






33. which B and T cell disorder presents with specifically low IgM?






34. which antibodies prevent antigens from binding mucosal surfaces?






35. what prevents NK cells from killing normal cells if their default is to kill?






36. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






37. What is anergy? why does this occur?






38. What is the general structure of an Ab?






39. What is recomb alpha interferon used for?






40. What does granzyme do? who secretes it?






41. The two heavy chains of an antibody contribute to the...






42. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






43. Which disease is associated with HLA A3?






44. What are the autoantibodies for drug induced lupus?






45. The Fc region is found on the...






46. What happens in a secondary follicle?






47. What are the main symptoms of T cell immunodeficiencies?






48. How is the antigen loaded onto a MHC II?






49. The secondary follicles have __________; primary follicles are dense






50. what happens in a deficiency of C1 esterase inhibitor? DAF?