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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Give an example of someone who could get hyperacute transplant rejection.






2. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






3. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






4. Which is the most abundant antibody in blood?






5. What is the white pulp of the spleen?






6. What does IgA pick up from epithelial cells before being secreted?






7. What are the mediators that mast cells release?






8. which of the transplant rejections is antibody mediated? why does it occur?






9. What lymph node drains the rectum (above the pectinate line)?






10. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






11. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






12. Which diseases are associated with DR5?






13. Which cytokines do Th2 release and For what?






14. Which disease is associated with B8?






15. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






16. How does complement link innate and adaptive?






17. other than mediating shock - what else does TNF alpha do? who releases it mainly?






18. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






19. which of the hypersensitivity reactions is not Ab mediated?






20. What is the clinical use for azathioprine?






21. What cytokines to Th2 secrete?






22. What is hereditary angioedema? What are the C3 levels?






23. The lymphocytes are ________ origin






24. What is the toxicity of muromonab?






25. What lymph node drains the stomach?






26. What are the two signals to kill for NK cells?






27. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






28. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






29. The MALT/GALT are not...






30. What is anergy? why does this occur?






31. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






32. IgM can fix complement but...






33. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






34. What does IL 4 do?






35. What is the defect in hyper IgM syndrome? What are the lab results?






36. So antibodies are the effectors for the humoral response. List some of their functions.






37. Which is the main antibody that provides passive immunity to infants?






38. Other than stimulating fever - what else does IL 6 do?






39. other than eat and bite RBCs what else do Macrophages of spleen do>






40. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






41. What is the pathogenesis of a candida skin test?






42. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






43. What are the autoantibodies for goodpastures syndrome?






44. What is the presentation of Brutons agammaglobulinemia?






45. What are the symptoms of serum sickness?






46. What type of side chains are found on Fc region of an antibody?






47. What is the most common selective Ig deficiency? What is the presentation?






48. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






49. What are the two signals required for T cells? what happens after?






50. What do mature naive B lymphocytes express?