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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






2. What is Aldesleukin? What is it used for






3. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






4. What is recomb gamma interferon used for?






5. The alternative pathway is the only constutively...






6. What are the three types of lymphocytes?






7. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






8. What type of fenestrations are found in the red pulp of the spleen?






9. What lymph node drains the scrotum?






10. What is chronic mucocutaneous candidiasis d/t?






11. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






12. Describe the complement independent Type II hypersenstivity reaction. Give an example.






13. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






14. What do mature naive B lymphocytes express?






15. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






16. What is filgrastim and sargramostim? and What is it used for?






17. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






18. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






19. What are the major functions of Antibodies?






20. where do somatic hypermutation and class switching occur?






21. What are some sinopulmonary infections?






22. other than mediating shock - what else does TNF alpha do? who releases it mainly?






23. Complements are...






24. which B and T cell disorder presents with specifically low IgM?






25. What is the clinical use for azathioprine?






26. What is the common variable immunodeficiency ? How is it different from Brutons?






27. What portion of the lymph node is not well developed in DiGeorge Syndrome?






28. What are the autoantibodies for Mixed connective tissue disease?






29. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






30. What is the late phase reaction of anaphylaxis allergy? what mediates it?






31. What are the autoantibodies for primary biliary cirrhosis?






32. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






33. are Th cells involved in trapping of antigens of endotoxin/LPS?






34. What is the pathology seen in chronic transplant rejection?






35. Which cytokines do Th2 release and For what?






36. So antibodies are the effectors for the humoral response. List some of their functions.






37. What is the pathogenesis of acute transplant rejection? When does it occur?






38. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






39. What happens in a secondary follicle?






40. What does granulysin do?






41. What can cause a lymph node enlargement?






42. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






43. The MALT/GALT are not...






44. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






45. Other than stimulating fever - what else does IL 6 do?






46. Which diseases are associated with DR2?






47. What are the two signals required for T cells? what happens after?






48. What are the symptoms of serum sickness?






49. How fast does it occur?






50. What is anergy? why does this occur?