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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Type IV hypersensitivity is i...






2. What does interferon gamma do? What two type of cells does it attack mostly?






3. What is the toxicity of azathioprine?






4. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






5. What is three common causes of severe combined immunodef? What is the result of all three?






6. To what disease do the autoantibodies to IgG (rheumatoid factor)?






7. What are some sinopulmonary infections?






8. In thymic development - What is the positive selection? negative selections?






9. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






10. which interleukin receptor is required for NK development? activation?






11. What is the presentation of common variable immunodef? and What are the labs?






12. what prevents NK cells from killing normal cells if their default is to kill?






13. What are the two signals required for B cell class switching? Which is the second signal?






14. What are the autoantibodies for primary biliary cirrhosis?






15. What are the autoantibodies for pemphigus bulgaris?






16. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






17. hat is the presentation of Jobs syndrome or Hyper IgE?






18. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






19. Which are the only two antiinflammatory cytokines?






20. Give an example of someone who could get hyperacute transplant rejection.






21. What lymph node drains the rectum (above the pectinate line)?






22. How does igA cross the epithelium?






23. What is the pathogenesis of a hypersensitivity reaction?






24. What is colostrum?






25. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






26. What is Aldesleukin? What is it used for






27. How is sirolimus different from tacrolimus?






28. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






29. What is the pathogenesis of a candida skin test?






30. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






31. which cells have more complete tolerance - B or T cells?






32. What is the pathogenesis of acute transplant rejection? When does it occur?






33. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






34. What is the main function of interferons?






35. What does granulysin do?






36. other than C3a - what other complement acts as an anaphyloxin?






37. when can graft versus host disease? What is the result?






38. What are target cells?






39. What lymph node drains the anal canal (below the pectinate line)?






40. What links the adaptive and innate immunity?






41. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






42. What does IgA pick up from epithelial cells before being secreted?






43. Only the _______ contribute to the Fc region






44. are Th cells involved in trapping of antigens of endotoxin/LPS?






45. What lymph node drains the upper limb?






46. To what portion of the Antibody do the complements bind?






47. What are the main symptoms of B cell immunodeficiencies?






48. What do mature naive B lymphocytes express?






49. which type of immunity is slow but long lasting? as opposed to...






50. What is the cause of thymic aplasia? What is its presentation? What are the labs?