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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which type of selection of thymic development provides central tolerance?






2. describe the pathogenesis of delayed type IV hypersensitivity






3. Which is the main antibody in the delayed or secondary response to an antigen?






4. What kinds of receptors activate innate immunity?






5. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






6. hat is the presentation of Jobs syndrome or Hyper IgE?






7. What happens in a deficiency of C3?






8. What is filgrastim and sargramostim? and What is it used for?






9. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






10. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






11. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






12. What is colostrum?






13. What is epo used for?






14. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






15. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






16. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






17. What lymph node drains the breast?






18. where do NK cells develop?






19. which type of immunity is slow but long lasting? as opposed to...






20. What are the autoantibodies for goodpastures syndrome?






21. Give three examples of bacteria that use antigenic variation and how.






22. The lymphocytes are ________ origin






23. which antibodies can bind complement?






24. can igG cross the placenta?






25. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






26. The secondary follicles have __________; primary follicles are dense






27. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






28. What are the autoantibodies for type I diabetes mellitus?






29. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






30. What do multimeric antibodies require for assembly?






31. What is muromonab - CD3 (OKT3)






32. What is the late phase reaction of anaphylaxis allergy? what mediates it?






33. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






34. A lymph node is a ________ lymphoid organ.






35. What are the two signals required for B cell class switching? Which is the second signal?






36. How does igA cross the epithelium?






37. What lymph node drains the stomach?






38. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






39. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






40. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






41. Which HLA's are included in MHC I? MHC II?


42. What is the main function of IL 8?






43. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






44. What is passive immunity?






45. What are the autoantibodies for pemphigus bulgaris?






46. How is the antigen loaded onto a MHC II?






47. Which disease is associated with DR7?






48. What is the main function of TNF alpha? How does it do this?






49. What are the autoantibodies for systemic sclerosis?






50. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.