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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which disease is associated with DR7?






2. In general What are T cells good for?






3. What are target cells?






4. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






5. In thymic development - What is the positive selection? negative selections?






6. Which diseases are associated with DR2?






7. What are the main symptoms of T cell immunodeficiencies?






8. What are the cell surface proteins for Macrophages? which two are for opsonins?






9. What is the presentation of scid? treatment?






10. What is three common causes of severe combined immunodef? What is the result of all three?






11. What is the clinical use for azathioprine?






12. What are the autoantibodies for pernicious anemia?






13. What lymph node drains the stomach?






14. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






15. How does igA cross the epithelium?






16. Only the _______ contribute to the Fc region






17. which of the hypersensitivity reactions is not Ab mediated?






18. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






19. What does IL 2 do?






20. How is the thymus organized? what happens in each section?






21. What is passive immunity?






22. What lymph node drains the rectum (above the pectinate line)?






23. How does the alternative pathway lead to MAC activation?






24. is IgM an opsonizer?






25. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






26. when can graft versus host disease? What is the result?






27. What does granzyme do? who secretes it?






28. Describe complement dependent Type II hypersensitivity. Give an example.






29. what results in symptoms of shock in an acute hemolytic transfusion reaction?






30. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






31. What lymph node drains the lateral side of the dorsum of the foot?






32. IgM can exist as a _______ also






33. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






34. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






35. Which disease is associated with HLA A3?






36. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






37. What are the major functions of Antibodies?






38. which antibody activate mast cells - basophils - and eosinophils?






39. What are the T cell functions?






40. What lymph node drains the anal canal (below the pectinate line)?






41. What is the receptor for EBV? On what cells is that located?






42. What is recomb alpha interferon used for?






43. What are the autoantibodies for autoimmune hepatitis?






44. ________ regulate the cell mediated response.






45. What are the two signals required for T cells? what happens after?






46. What lymph node drains the duodenum - jejunum?






47. What are howell jolly bodies?






48. Which cytokines do Th2 release and For what?






49. What is recomb gamma interferon used for?






50. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?