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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.

2. The MALT/GALT are not...

3. What is the presentation of common variable immunodef? and What are the labs?

4. What is the general structure of an Ab?

5. What is the defect in hyper IgM syndrome? What are the lab results?

6. What does interferon gamma do to be antiviral?

7. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?

8. What is chronic mucocutaneous candidiasis d/t?

9. Which disease is associated with DR7?

10. What is digoxin immune Fab used for?

11. Which antibodies can be multimeric?

12. Only the _______ contribute to the Fc region

13. The Fc region is found on the...

14. Describe the Mannose Lectin pathway

15. What are the autoantibodies for hashimotos?

16. What is the marginal zone of the spleen? what happens there?

17. What is serum sickness? give an example.

18. IgG...

19. What are the cell surface proteins for Macrophages? which two are for opsonins?

20. What is the clinical use of Muromonab?

21. What is the pathogenesis of HyperIgE syndrome? What are the labs?

22. What is the main function of TNF alpha? How does it do this?

23. What lymph node drains the stomach?

24. What are the three types of lymphocytes?

25. What is the most common example of passive immunity?

26. What are the T cell functions?

27. what cytokine does basophils secrete?

28. The ______ in the BM are DN - the DP are in the cortex of thymus

29. All transplant rejections - _____________ are mediated by Type IV hypersensitivity

30. Leukocyte adhesion defect presents with...

31. which of the transplant rejections is antibody mediated? why does it occur?

32. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?

33. when can graft versus host disease? What is the result?

34. Give three examples of bacteria that use antigenic variation and how.

35. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?

36. What lymph node drains the thigh?

37. What is the presentation of hyperIgM syndrome?

38. What are the symptoms of serum sickness?

39. Complements are...

40. What is three common causes of severe combined immunodef? What is the result of all three?

41. What is the receptor for EBV? On what cells is that located?

42. From where do cytokines come from?

43. What is the treatment of acute transplant rejection?

44. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example

45. What is the toxicity of azathioprine?

46. What are the autoantibodies for polymyositis and dermatomyositis?

47. What is the pathology in hyperacute transplant rejection?

48. What happens in a deficiency of C3?

49. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?

50. What is Aldesleukin? What is it used for