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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






2. What is the late phase reaction of anaphylaxis allergy? what mediates it?






3. Which is the main antibody that provides passive immunity to infants?






4. what happens in a deficiency of C1 esterase inhibitor? DAF?






5. IgM can exist as a _______ also






6. What are the autoantibodies for hashimotos?






7. What does IL 10 do? who is secreted by?






8. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






9. What is the most common example of passive immunity?






10. What is the main function of interferons?






11. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






12. Name 5 ways Antibody diversity is generated?






13. What are howell jolly bodies?






14. What are the two signals required for Th1 cells? what happens after then activated?






15. Name the three opsonins






16. What is the main function of IL 8?






17. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






18. what ensure that a memory response is generated?






19. What are the autoantibodies for autoimmune hepatitis?






20. What is chronic mucocutaneous candidiasis d/t?






21. Only the _______ contribute to the Fc region






22. Describe the capsular structure of a lymph node; What are the functions of the LN?






23. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






24. What is the treatment of acute transplant rejection?






25. In thymic development - What is the positive selection? negative selections?






26. What type of side chains are found on Fc region of an antibody?






27. What does IL 2 do?






28. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






29. For which toxins are preformed antibodies (passive) given?






30. what secretes IL 4?






31. What bugs can actually infect the lymph node itself?






32. What is the white pulp of the spleen?






33. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






34. What is the pathogenesis of a candida skin test?






35. What is the main function of TNF alpha? How does it do this?






36. What are the autoantibodies for graves?






37. where do NK cells develop?






38. What is anergy? why does this occur?






39. which cytokine inhibits TH2 cells? secreted by who?






40. What are the autoantibodies for systemic sclerosis?






41. What lymph node drains the stomach?






42. What is the toxicity of muromonab?






43. What lymph node drains the lateral side of the dorsum of the foot?






44. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






45. Which disease is associated with DR3?






46. What are the function of B cells?






47. What is epo used for?






48. What is a factor that is a predictor for a bad transplantation?






49. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






50. are Th cells involved in trapping of antigens of endotoxin/LPS?