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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which MHC presents intracellular peptides? how so?






2. So antibodies are the effectors for the humoral response. List some of their functions.






3. What is a type I hypersensitivity reaction? What is atopic?






4. Describe the Mannose Lectin pathway






5. What is the common variable immunodeficiency ? How is it different from Brutons?






6. what cell surface proteins are on all APCs?






7. To what disease do the autoantibodies to IgG (rheumatoid factor)?






8. What is the late phase reaction of anaphylaxis allergy? what mediates it?






9. What is the clinical use for sirolimus? what should you combine it with?






10. To what portion of the Antibody do the complements bind?






11. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






12. Give three examples of bacteria that use antigenic variation and how.






13. ________ regulate the cell mediated response.






14. Type IV hypersensitivity is i...






15. What are the autoantibodies for wegeners granulomatosis?






16. What are the two signals required for T cells? what happens after?






17. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






18. A lymph node is a ________ lymphoid organ.






19. The ______ in the BM are DN - the DP are in the cortex of thymus






20. which cells have more complete tolerance - B or T cells?






21. What is the marginal zone of the spleen? what happens there?






22. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






23. What is the main function of IL 12? other than macrophages who else can release IL 12?






24. For which toxins are preformed antibodies (passive) given?






25. other than eat and bite RBCs what else do Macrophages of spleen do>






26. What lymph node drains the scrotum?






27. Which disease is associated with HLA A3?






28. Which disease is associated with DR3?






29. From where do cytokines come from?






30. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






31. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






32. What are some catalase positive organisms?






33. What is the pathogenesis of acute transplant rejection? When does it occur?






34. What are the three types of lymphocytes?






35. What is the main function of TNF alpha? How does it do this?






36. How does igA cross the epithelium?






37. What is serum sickness? give an example.






38. what ensure that a memory response is generated?






39. What is the presentation of common variable immunodef? and What are the labs?






40. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






41. What lymph node drains the thigh?






42. What does interferon gamma do? What two type of cells does it attack mostly?






43. What are the main symptoms of T cell immunodeficiencies?






44. What is the main function of IL 8?






45. What is a factor that is a predictor for a bad transplantation?






46. Name 5 ways Antibody diversity is generated?






47. What does granzyme do? who secretes it?






48. What is the defect in hyper IgM syndrome? What are the lab results?






49. What are the PALS?






50. where do NK cells develop?