Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is immune complex disease? give an example.






2. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






3. What are the PALS?






4. what cell surface proteins are on all APCs?






5. which type of immunity is slow but long lasting? as opposed to...






6. How fast does it occur?






7. __________ are a part of the innate system.






8. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






9. What is an example of a parasite showing antigenic variation?






10. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






11. What is the main function of IL 12? other than macrophages who else can release IL 12?






12. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






13. Name the three opsonins






14. What are the autoantibodies for hashimotos?






15. other than C3a - what other complement acts as an anaphyloxin?






16. What are the autoantibodies for wegeners granulomatosis?






17. what cell surface marker is used for NK cells as it is unique to them?






18. What are four results of a splenectomy?






19. The ______ in the BM are DN - the DP are in the cortex of thymus






20. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






21. What is the clinical use for sirolimus? what should you combine it with?






22. How do you test for chronic granulomatous disease?






23. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






24. The pathogenesis of contact dermatitis is ________ hypersensitivity






25. What is serum sickness? give an example.






26. What is hereditary angioedema? What are the C3 levels?






27. What are the autoantibodies for sjorgens syndrome?






28. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






29. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






30. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






31. what bacteria are a splenectomy patient most susceptible to? why?






32. What is Aldesleukin? What is it used for






33. What are the autoantibodies for Mixed connective tissue disease?






34. For which toxins are preformed antibodies (passive) given?






35. What is the pathogenesis of a candida skin test?






36. IgM can fix complement but...






37. IgG...






38. What lymph node drains the breast?






39. What does IL 5 do?






40. What are the main cell surface proteins on B cells?






41. What is the presentation of hyperIgM syndrome?






42. What is recomb gamma interferon used for?






43. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






44. What is the main function of interferons?






45. IgE has the ___________ in the serum






46. How do you test for type III hypersensitivity?






47. Describe the Mannose Lectin pathway






48. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






49. which antibodies prevent antigens from binding mucosal surfaces?






50. What are the two signals required for Th1 cells? what happens after then activated?