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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How is the antigen loaded onto a MHC II?






2. What are the main Cell surface proteins on T cells?






3. What is chronic mucocutaneous candidiasis d/t?






4. What are the autoantibodies for wegeners granulomatosis?






5. what ensure that a memory response is generated?






6. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






7. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






8. give an example of how influenza does a major antigenic shift.






9. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






10. What does granzyme do? who secretes it?






11. describe the pathogenesis of delayed type IV hypersensitivity






12. Monomer in circulation - ___ when secreted






13. Which disease is associated with B8?






14. What are the cell surface proteins on NK cells?






15. ________ regulate the cell mediated response.






16. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






17. which cells have more complete tolerance - B or T cells?






18. which antibody activate mast cells - basophils - and eosinophils?






19. What does IL 5 do?






20. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






21. What is the pathogenesis of acute transplant rejection? When does it occur?






22. What cytokines to Th2 secrete?






23. Describe the complement independent Type II hypersenstivity reaction. Give an example.






24. Name 5 ways Antibody diversity is generated?






25. What are the symptoms of serum sickness?






26. What are the autoantibodies for primary biliary cirrhosis?






27. What is immune complex disease? give an example.






28. What are some sinopulmonary infections?






29. What are the autoantibodies for pernicious anemia?






30. other than C3a - what other complement acts as an anaphyloxin?






31. Describe the capsular structure of a lymph node; What are the functions of the LN?






32. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






33. which cytokine inhibits TH2 cells? secreted by who?






34. when can graft versus host disease? What is the result?






35. Give an example of someone who could get hyperacute transplant rejection.






36. Give three examples of bacteria that use antigenic variation and how.






37. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






38. IgM can fix complement but...






39. The two heavy chains of an antibody contribute to the...






40. What lymph node drains the rectum (above the pectinate line)?






41. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






42. what prevents NK cells from killing normal cells if their default is to kill?






43. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






44. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






45. What is the pathology in hyperacute transplant rejection?






46. What are the two signals required for T cells? what happens after?






47. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






48. Which are the only two antiinflammatory cytokines?






49. IgE has the ___________ in the serum






50. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?