Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What does Interferon alpha and beta do? how?






2. What does interferon gamma do? What two type of cells does it attack mostly?






3. What kinds of receptors activate innate immunity?






4. What is the mechanism for sirolimus? what else it known as?






5. What are the main symptoms of B cell immunodeficiencies?






6. To what disease do the autoantibodies to IgG (rheumatoid factor)?






7. What are the autoantibodies for Mixed connective tissue disease?






8. The pathogenesis of contact dermatitis is ________ hypersensitivity






9. __________ are a part of the innate system.






10. What are the autoantibodies for hashimotos?






11. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






12. what mediates the type II hypersensitivity? What are the two different methods?






13. give an example of how influenza does a major antigenic shift.






14. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






15. what prevents NK cells from killing normal cells if their default is to kill?






16. What is the general structure of an Ab?






17. Type IV hypersensitivity is i...






18. what cytokine does basophils secrete?






19. What is the most common example of passive immunity?






20. What is muromonab - CD3 (OKT3)






21. Give an example of someone who could get hyperacute transplant rejection.






22. What is the marginal zone of the spleen? what happens there?






23. Only the _______ contribute to the Fc region






24. What does granulysin do?






25. What is the main cytokine released by T cells? What does it do






26. How is sirolimus different from tacrolimus?






27. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






28. What are the autoantibodies for type I diabetes mellitus?






29. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






30. What is the pathogenesis of acute transplant rejection? When does it occur?






31. What are the major functions of Antibodies?






32. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






33. What is the presentation of Brutons agammaglobulinemia?






34. What is the most common selective Ig deficiency? What is the presentation?






35. What is Aldesleukin? What is it used for






36. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






37. What is the presentation of hyperIgM syndrome?






38. What does IL 10 do? who is secreted by?






39. What lymph node drains the testes?






40. What are MHC's necessary for? By themselves?






41. What is recomb beta interferon used for?






42. What are the symptoms of serum sickness?






43. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






44. What are the autoantibodies for sjorgens syndrome?






45. What is the pathology of acute transplant rejection? is it reversible?






46. What does IgA pick up from epithelial cells before being secreted?






47. What is the common variable immunodeficiency ? How is it different from Brutons?






48. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






49. What is the receptor for EBV? On what cells is that located?






50. Describe the capsular structure of a lymph node; What are the functions of the LN?