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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which disease is associated with B8?






2. hat is the presentation of Jobs syndrome or Hyper IgE?






3. The idiotype; the Fc portion determines the...






4. Describe the complement independent Type II hypersenstivity reaction. Give an example.






5. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






6. What are some catalase positive organisms?






7. Give three examples of bacteria that use antigenic variation and how.






8. What lymph node drains the thigh?






9. can igG cross the placenta?






10. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






11. What is Aldesleukin? What is it used for






12. What are target cells?






13. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






14. what prevents NK cells from killing normal cells if their default is to kill?






15. What are the main Cell surface proteins on T cells?






16. What is the defect in hyper IgM syndrome? What are the lab results?






17. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






18. What is the pathogenesis of a candida skin test?






19. which antibody activate mast cells - basophils - and eosinophils?






20. What is the common variable immunodeficiency ? How is it different from Brutons?






21. What is the autoantibody for SLE that is nonspecific? Specific?






22. What are the autoantibodies for systemic sclerosis?






23. The ______ in the BM are DN - the DP are in the cortex of thymus






24. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






25. What is three common causes of severe combined immunodef? What is the result of all three?






26. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






27. Which antibody mediates immunity to worms? how?






28. is IgM an opsonizer?






29. The lymphocytes are ________ origin






30. How is i Th1 helper cell inhibited?






31. __________ are a part of the innate system.






32. Which cytokines do Th2 release and For what?






33. describe the classic complement pathway.






34. which type of immunity is slow but long lasting? as opposed to...






35. What are the autoantibodies for type I diabetes mellitus?






36. What is the main function of interferons?






37. Which MHC presents intracellular peptides? how so?






38. What are the PALS?






39. What cytokines are released by Th1 cells?






40. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






41. Type Iv hypersensitivity is...






42. Which are the only two antiinflammatory cytokines?






43. what secretes IL 4?






44. The Fc region is found on the...






45. Which antibodies can be multimeric?






46. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






47. What are howell jolly bodies?






48. Only the _______ contribute to the Fc region






49. Complements are...






50. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?