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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the pathology of acute transplant rejection? is it reversible?






2. What does Interferon alpha and beta do? how?






3. what happens in a deficiency of C1 esterase inhibitor? DAF?






4. What are the main symptoms of B cell immunodeficiencies?






5. What lymph node drains the thigh?






6. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






7. what prevents NK cells from killing normal cells if their default is to kill?






8. What is the pathogenesis of a candida skin test?






9. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






10. What is the mechanism for sirolimus? what else it known as?






11. How is i Th1 helper cell inhibited?






12. What lymph node drains the sigmoid colon?






13. What are the PALS?






14. Which are the only two antiinflammatory cytokines?






15. What do multimeric antibodies require for assembly?






16. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






17. For which toxins are preformed antibodies (passive) given?






18. What is hereditary angioedema? What are the C3 levels?






19. What are the two signals required for T cells? what happens after?






20. what secretes IL 4?






21. What is the general structure of an Ab?






22. What are the autoantibodies for myasthenia gravis?






23. What are the autoantibodies for Celiac disease?






24. What is the clinical use for azathioprine?






25. What are the two signals required for B cell class switching? Which is the second signal?






26. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






27. So antibodies are the effectors for the humoral response. List some of their functions.






28. where do somatic hypermutation and class switching occur?






29. which cytokine inhibits TH2 cells? secreted by who?






30. What is the pathology seen in chronic transplant rejection?






31. what bacteria are a splenectomy patient most susceptible to? why?






32. Describe the complement independent Type II hypersenstivity reaction. Give an example.






33. What are the function of B cells?






34. What are the main symptoms of T cell immunodeficiencies?






35. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






36. What are superantigens? give two examples.






37. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






38. What are the main Cell surface proteins on T cells?






39. What are some sinopulmonary infections?






40. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






41. What are the autoantibodies for other vasculitides?






42. What is the defect in hyper IgM syndrome? What are the lab results?






43. What does IL 2 do?






44. To what portion of the Antibody do the complements bind?






45. IgM can fix complement but...






46. A lymph node is a ________ lymphoid organ.






47. What lymph node drains the anal canal (below the pectinate line)?






48. in which immunodef order do you see a lot of pus? no pus?






49. Which HLA's are included in MHC I? MHC II?

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50. other than eat and bite RBCs what else do Macrophages of spleen do>