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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






2. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






3. What is the main function of IL 8?






4. Which HLA's are included in MHC I? MHC II?

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5. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






6. which type of immunity is slow but long lasting? as opposed to...






7. Describe the Mannose Lectin pathway






8. What are the autoantibodies for drug induced lupus?






9. other than mediating shock - what else does TNF alpha do? who releases it mainly?






10. What are the autoantibodies for other vasculitides?






11. What is immune complex disease? give an example.






12. What is a type I hypersensitivity reaction? What is atopic?






13. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






14. What lymph node drains the stomach?






15. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






16. Which helper T cells' development is induced by IL 4? IL 12?






17. What are the main Cell surface proteins on T cells?






18. What are the two signals required for Th1 cells? what happens after then activated?






19. What is anergy? why does this occur?






20. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






21. hat is the presentation of Jobs syndrome or Hyper IgE?






22. What is three common causes of severe combined immunodef? What is the result of all three?






23. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






24. How does igA cross the epithelium?






25. what bacteria are a splenectomy patient most susceptible to? why?






26. what mediates the type II hypersensitivity? What are the two different methods?






27. What is filgrastim and sargramostim? and What is it used for?






28. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






29. What is the late phase reaction of anaphylaxis allergy? what mediates it?






30. How fast does it occur?






31. Describe the capsular structure of a lymph node; What are the functions of the LN?






32. What is the toxicity of azathioprine?






33. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






34. What can cause a lymph node enlargement?






35. what characterizes an arthus reaction?






36. Which antibody mediates immunity to worms? how?






37. what prevents NK cells from killing normal cells if their default is to kill?






38. The MALT/GALT are not...






39. What happens in a deficiency of C3?






40. Name the three opsonins






41. What is serum sickness? give an example.






42. What are C1 - C2 - C3 - C4 important for?






43. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






44. What cytokines are released by Th1 cells?






45. To what disease do the autoantibodies to IgG (rheumatoid factor)?






46. What does IL 2 do?






47. What are the two signals to kill for NK cells?






48. What do multimeric antibodies require for assembly?






49. What are the autoantibodies for autoimmune hepatitis?






50. Which are the only two antiinflammatory cytokines?