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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is recomb gamma interferon used for?






2. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






3. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






4. What are the cell surface proteins for Macrophages? which two are for opsonins?






5. What is immune complex disease? give an example.






6. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






7. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






8. What are MHC's necessary for? By themselves?






9. What lymph node drains the stomach?






10. In general What are T cells good for?






11. What kinds of receptors activate innate immunity?






12. What does IgA pick up from epithelial cells before being secreted?






13. What is the receptor for EBV? On what cells is that located?






14. What are some catalase positive organisms?






15. what results in symptoms of shock in an acute hemolytic transfusion reaction?






16. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






17. What does it mean if there are igM in the serum at birth?






18. What are the symptoms of serum sickness?






19. when can graft versus host disease? What is the result?






20. What is recomb beta interferon used for?






21. Which disease is associated with HLA A3?






22. What does CD16 on NK cells do?






23. What are the main cell surface proteins on B cells?






24. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






25. What are some sinopulmonary infections?






26. IgM can fix complement but...






27. What lymph node drains the sigmoid colon?






28. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






29. What is the late phase reaction of anaphylaxis allergy? what mediates it?






30. The idiotype; the Fc portion determines the...






31. Which diseases are associated with DR5?






32. What links the adaptive and innate immunity?






33. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






34. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






35. what prevents NK cells from killing normal cells if their default is to kill?






36. In thymic development - What is the positive selection? negative selections?






37. where do somatic hypermutation and class switching occur?






38. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






39. What lymph node drains the breast?






40. other than mediating shock - what else does TNF alpha do? who releases it mainly?






41. What cytokines to Th2 secrete?






42. What is the cause of thymic aplasia? What is its presentation? What are the labs?






43. Describe the capsular structure of a lymph node; What are the functions of the LN?






44. What is the toxicity of azathioprine?






45. Leukocyte adhesion defect presents with...






46. can igG cross the placenta?






47. What are the major functions of Antibodies?






48. What is the pathogenesis of a candida skin test?






49. What lymph node drains the scrotum?






50. What is Aldesleukin? What is it used for