Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the anal canal (below the pectinate line)?






2. What type of side chains are found on Fc region of an antibody?






3. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






4. From where do cytokines come from?






5. in which immunodef order do you see a lot of pus? no pus?






6. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






7. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






8. Only the _______ contribute to the Fc region






9. describe the classic complement pathway.






10. what will NK cells do to cells covered in IgG Ab? why?






11. What are the two signals required for Th1 cells? what happens after then activated?






12. What is passive immunity?






13. which cells have more complete tolerance - B or T cells?






14. What are the autoantibodies for graves?






15. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






16. What are the labs in brutons agammaglobulinemia?






17. How fast does it occur?






18. Which type of selection of thymic development provides central tolerance?






19. Which are the only two antiinflammatory cytokines?






20. What bugs can actually infect the lymph node itself?






21. What is the autoantibody for SLE that is nonspecific? Specific?






22. How is the thymus organized? what happens in each section?






23. What happens in a deficiency of C3?






24. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






25. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






26. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






27. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






28. What is the general structure of an Ab?






29. What are the function of B cells?






30. which cytokine inhibits TH2 cells? secreted by who?






31. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






32. __________ are a part of the innate system.






33. What does IgA pick up from epithelial cells before being secreted?






34. Which is the main antibody in the delayed or secondary response to an antigen?






35. What are the autoantibodies for myasthenia gravis?






36. other than C3a - what other complement acts as an anaphyloxin?






37. What are the main cell surface proteins on B cells?






38. What is Aldesleukin? What is it used for






39. what characterizes an arthus reaction?






40. What are the autoantibodies for systemic sclerosis?






41. can igG cross the placenta?






42. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






43. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






44. Describe the complement independent Type II hypersenstivity reaction. Give an example.






45. What is the presentation of common variable immunodef? and What are the labs?






46. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






47. What does granulysin do?






48. other than eat and bite RBCs what else do Macrophages of spleen do>






49. What can cause a lymph node enlargement?






50. Which is the main antibody that provides passive immunity to infants?