Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. in which immunodef order do you see a lot of pus? no pus?






2. What does it mean if there are igM in the serum at birth?






3. Complements are...






4. What is the main function of TNF alpha? How does it do this?






5. What is digoxin immune Fab used for?






6. What is the main cytokine that activates eosinophils?






7. What are the two signals required for T cells? what happens after?






8. What is the pathogenesis of acute transplant rejection? When does it occur?






9. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






10. are Th cells involved in trapping of antigens of endotoxin/LPS?






11. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






12. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






13. What are superantigens? give two examples.






14. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






15. What is recomb beta interferon used for?






16. What does IgA pick up from epithelial cells before being secreted?






17. Describe the capsular structure of a lymph node; What are the functions of the LN?






18. What are the autoantibodies for autoimmune hepatitis?






19. What is the clinical use of Muromonab?






20. What are MHC's necessary for? By themselves?






21. What is the presentation of Brutons agammaglobulinemia?






22. To what disease do the autoantibodies to IgG (rheumatoid factor)?






23. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






24. what secretes IL 4?






25. What is oprelevkin? and What is it used for?






26. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






27. Which disease is associated with HLA A3?






28. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






29. What is the general structure of an Ab?






30. What do multimeric antibodies require for assembly?






31. Which is the most abundant antibody in blood?






32. What is the white pulp of the spleen?






33. The secondary follicles have __________; primary follicles are dense






34. What are C1 - C2 - C3 - C4 important for?






35. In thymic development - What is the positive selection? negative selections?






36. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






37. What is the common variable immunodeficiency ? How is it different from Brutons?






38. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






39. What links the adaptive and innate immunity?






40. What are the autoantibodies for Celiac disease?






41. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






42. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






43. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






44. What does interferon gamma do? What two type of cells does it attack mostly?






45. The pathogenesis of contact dermatitis is ________ hypersensitivity






46. What lymph node drains the scrotum?






47. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






48. what prevents NK cells from killing normal cells if their default is to kill?






49. Other than stimulating fever - what else does IL 6 do?






50. What are the autoantibodies for graves?






Can you answer 50 questions in 15 minutes?



Let me suggest you:



Major Subjects



Tests & Exams


AP
CLEP
DSST
GRE
SAT
GMAT

Most popular tests