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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for Celiac disease?






2. What is the common variable immunodeficiency ? How is it different from Brutons?






3. Which diseases are associated with DR4?






4. What is the receptor for EBV? On what cells is that located?






5. IgE has the ___________ in the serum






6. What does IL 5 do?






7. What is the clinical use for azathioprine?






8. which of the transplant rejections is antibody mediated? why does it occur?






9. Describe the Mannose Lectin pathway






10. Type IV hypersensitivity is i...






11. What is thrombopoietin used for?






12. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






13. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






14. What is the main cytokine that activates eosinophils?






15. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






16. What links the adaptive and innate immunity?






17. What is the autoantibody for SLE that is nonspecific? Specific?






18. What are the autoantibodies for Mixed connective tissue disease?






19. Which antibodies can be multimeric?






20. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






21. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






22. can igG cross the placenta?






23. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






24. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






25. How does igA cross the epithelium?






26. Which HLA's are included in MHC I? MHC II?

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27. What is the pathogenesis of acute transplant rejection? When does it occur?






28. which antibodies prevent antigens from binding mucosal surfaces?






29. What are C1 - C2 - C3 - C4 important for?






30. Which diseases are associated with DR5?






31. What are the autoantibodies for primary biliary cirrhosis?






32. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






33. Give an example of someone who could get hyperacute transplant rejection.






34. What are the main cell surface proteins on B cells?






35. What are the major functions of Antibodies?






36. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






37. What lymph node drains the lateral side of the dorsum of the foot?






38. What is the marginal zone of the spleen? what happens there?






39. which type of immunity is slow but long lasting? as opposed to...






40. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






41. Which is the most abundant antibody in blood?






42. What is a factor that is a predictor for a bad transplantation?






43. What cytokines to Th2 secrete?






44. what happens in a deficiency of C1 esterase inhibitor? DAF?






45. What does it mean if there are igM in the serum at birth?






46. The two heavy chains of an antibody contribute to the...






47. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






48. in which immunodef order do you see a lot of pus? no pus?






49. What is the late phase reaction of anaphylaxis allergy? what mediates it?






50. From where do cytokines come from?