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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The MALT/GALT are not...






2. What are the two signals required for Th1 cells? what happens after then activated?






3. What are the labs in brutons agammaglobulinemia?






4. Describe the complement independent Type II hypersenstivity reaction. Give an example.






5. what secretes IL 4?






6. What are some sinopulmonary infections?






7. What is the main function of interferons?






8. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






9. What are the autoantibodies for pemphigus bulgaris?






10. What are the autoantibodies for other vasculitides?






11. Type Iv hypersensitivity is...






12. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






13. Which MHC presents intracellular peptides? how so?






14. The pathogenesis of contact dermatitis is ________ hypersensitivity






15. Other than stimulating fever - what else does IL 6 do?






16. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






17. What are the main cell surface proteins on B cells?






18. What is the clinical use of Muromonab?






19. what cytokine does basophils secrete?






20. The secondary follicles have __________; primary follicles are dense






21. What links the adaptive and innate immunity?






22. Which is the most abundant antibody in blood?






23. what prevents NK cells from killing normal cells if their default is to kill?






24. What are the mediators that mast cells release?






25. How do you test for type III hypersensitivity?






26. What lymph node drains the scrotum?






27. So antibodies are the effectors for the humoral response. List some of their functions.






28. What is the main function of IL 12? other than macrophages who else can release IL 12?






29. What is the mechanism for sirolimus? what else it known as?






30. What is anergy? why does this occur?






31. which antibody is involved in the primary response or immediate response to an antigen?






32. What are the two signals required for T cells? what happens after?






33. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






34. What are the cell surface proteins on NK cells?






35. What is the white pulp of the spleen?






36. What are C1 - C2 - C3 - C4 important for?






37. __________ are a part of the innate system.






38. What cytokines to Th2 secrete?






39. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






40. Which diseases are associated with DR2?






41. Which disease is associated with HLA A3?






42. To what portion of the Antibody do the complements bind?






43. What is serum sickness? give an example.






44. What is the main cytokine that activates eosinophils?






45. What is the treatment of acute transplant rejection?






46. Describe complement dependent Type II hypersensitivity. Give an example.






47. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






48. What portion of the lymph node is not well developed in DiGeorge Syndrome?






49. What does interferon gamma do to be antiviral?






50. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?