Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






2. What does Interferon alpha and beta do? how?






3. The secondary follicles have __________; primary follicles are dense






4. What are the main symptoms of T cell immunodeficiencies?






5. What is hereditary angioedema? What are the C3 levels?






6. What do mature naive B lymphocytes express?






7. What are the autoantibodies for myasthenia gravis?






8. What lymph node drains the anal canal (below the pectinate line)?






9. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






10. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






11. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






12. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






13. What is the main function of IL 8?






14. So antibodies are the effectors for the humoral response. List some of their functions.






15. What is the main function of IL 12? other than macrophages who else can release IL 12?






16. The idiotype; the Fc portion determines the...






17. What links the adaptive and innate immunity?






18. What are the autoantibodies for drug induced lupus?






19. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






20. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






21. What are the PALS?






22. Which disease is associated with DR3?






23. What happens in a deficiency of C3?






24. A lymph node is a ________ lymphoid organ.






25. What are the symptoms of serum sickness?






26. What is the pathogenesis of acute transplant rejection? When does it occur?






27. Which disease is associated withB B27?






28. What does granzyme do? who secretes it?






29. what bacteria are a splenectomy patient most susceptible to? why?






30. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






31. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






32. give an example of how influenza does a major antigenic shift.






33. what happens in a deficiency of C1 esterase inhibitor? DAF?






34. What are the autoantibodies for graves?






35. What does interferon gamma do? What two type of cells does it attack mostly?






36. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






37. Which cytokines do Th2 release and For what?






38. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






39. IgE has the ___________ in the serum






40. is IgM an opsonizer?






41. are Th cells involved in trapping of antigens of endotoxin/LPS?






42. What is the main cytokine released by T cells? What does it do






43. ________ regulate the cell mediated response.






44. What cytokines are released by Th1 cells?






45. What can cause a lymph node enlargement?






46. The ______ in the BM are DN - the DP are in the cortex of thymus






47. Which antibodies can be multimeric?






48. To what disease do the autoantibodies to IgG (rheumatoid factor)?






49. Which disease is associated with DR7?






50. What lymph node drains the stomach?