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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. __________ are a part of the innate system.






2. How is the thymus organized? what happens in each section?






3. The MALT/GALT are not...






4. where do NK cells develop?






5. Which antibodies can be multimeric?






6. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






7. From where do cytokines come from?






8. What is the general structure of an Ab?






9. What lymph node drains the anal canal (below the pectinate line)?






10. in which immunodef order do you see a lot of pus? no pus?






11. What is Aldesleukin? What is it used for






12. What is passive immunity?






13. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






14. What are the autoantibodies for Celiac disease?






15. which cytokine inhibits TH2 cells? secreted by who?






16. Which HLA's are included in MHC I? MHC II?

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17. How is the antigen loaded onto a MHC II?






18. What lymph node drains the scrotum?






19. What are superantigens? give two examples.






20. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






21. describe the pathogenesis of delayed type IV hypersensitivity






22. What is the toxicity of azathioprine?






23. What happens in a secondary follicle?






24. What are four results of a splenectomy?






25. Which are the only two antiinflammatory cytokines?






26. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






27. What bugs can actually infect the lymph node itself?






28. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






29. What are the three types of APCs?






30. Describe the Mannose Lectin pathway






31. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






32. What is recomb alpha interferon used for?






33. What is the cause of thymic aplasia? What is its presentation? What are the labs?






34. How do you test for type III hypersensitivity?






35. IgM can exist as a _______ also






36. what bacteria are a splenectomy patient most susceptible to? why?






37. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






38. What are the autoantibodies for polymyositis and dermatomyositis?






39. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






40. How does igA cross the epithelium?






41. What are the cell surface proteins on NK cells?






42. What does granzyme do? who secretes it?






43. What happens in a deficiency of C3?






44. What are the autoantibodies for sjorgens syndrome?






45. Which MHC presents intracellular peptides? how so?






46. What are the autoantibodies for myasthenia gravis?






47. What are the PALS?






48. Which disease is associated withB B27?






49. What links the adaptive and innate immunity?






50. What are the autoantibodies for goodpastures syndrome?