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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which MHC presents intracellular peptides? how so?

2. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?

3. How fast does it occur?

4. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?

5. What is the pathology seen in chronic transplant rejection?

6. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?

7. How is the antigen loaded onto a MHC II?

8. What is the marginal zone of the spleen? what happens there?

9. What is muromonab - CD3 (OKT3)

10. What are some catalase positive organisms?

11. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?

12. What are the autoantibodies for Mixed connective tissue disease?

13. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?

14. All transplant rejections - _____________ are mediated by Type IV hypersensitivity

15. What are the autoantibodies for primary biliary cirrhosis?

16. What are MHC's necessary for? By themselves?

17. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?

18. What does interferon gamma do to be antiviral?

19. What does IL 10 do? who is secreted by?

20. Which diseases are associated with DR2?

21. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?

22. what ensure that a memory response is generated?

23. What are the autoantibodies for myasthenia gravis?

24. What are the autoantibodies for drug induced lupus?

25. IgE has the ___________ in the serum

26. What happens in a deficiency of C3?

27. What are the main Cell surface proteins on T cells?

28. What does IgA pick up from epithelial cells before being secreted?

29. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?

30. How is sirolimus different from tacrolimus?

31. What type of side chains are found on Fc region of an antibody?

32. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?

33. What are some sinopulmonary infections?

34. what results in symptoms of shock in an acute hemolytic transfusion reaction?

35. What are the major functions of Antibodies?

36. What kinds of receptors activate innate immunity?

37. what mediates the type II hypersensitivity? What are the two different methods?

38. what cell surface marker is used for NK cells as it is unique to them?

39. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?

40. What lymph node drains the breast?

41. other than mediating shock - what else does TNF alpha do? who releases it mainly?

42. How do you test for type III hypersensitivity?

43. The idiotype; the Fc portion determines the...

44. What are the four steps in phagocytosis? What are the four disease that correspond to each step?

45. which of the hypersensitivity reactions is not Ab mediated?

46. What does Interferon alpha and beta do? how?

47. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?

48. What are the three types of lymphocytes?

49. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response

50. What are the autoantibodies for pernicious anemia?