Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the pathogenesis of HyperIgE syndrome? What are the labs?






2. What are the function of B cells?






3. what characterizes an arthus reaction?






4. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






5. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






6. what bacteria are a splenectomy patient most susceptible to? why?






7. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






8. Which MHC presents intracellular peptides? how so?






9. The lymphocytes are ________ origin






10. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






11. What does CD16 on NK cells do?






12. Which is the main antibody that provides passive immunity to infants?






13. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






14. What is three common causes of severe combined immunodef? What is the result of all three?






15. To what disease do the autoantibodies to IgG (rheumatoid factor)?






16. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






17. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






18. What are the labs in brutons agammaglobulinemia?






19. What are the autoantibodies for graves?






20. What is the pathology seen in chronic transplant rejection?






21. What is the main cytokine released by T cells? What does it do






22. What cytokines to Th2 secrete?






23. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






24. What links the adaptive and innate immunity?






25. Describe the capsular structure of a lymph node; What are the functions of the LN?






26. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






27. What are the autoantibodies for other vasculitides?






28. Which helper T cells' development is induced by IL 4? IL 12?






29. What are the autoantibodies for primary biliary cirrhosis?






30. What is epo used for?






31. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






32. What is the toxicity of muromonab?






33. What are the autoantibodies for hashimotos?






34. Which disease is associated with HLA A3?






35. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






36. what prevents NK cells from killing normal cells if their default is to kill?






37. What are the autoantibodies for autoimmune hepatitis?






38. What is recomb alpha interferon used for?






39. which cytokine inhibits TH2 cells? secreted by who?






40. What does IL 10 do? who is secreted by?






41. What is oprelevkin? and What is it used for?






42. What are the autoantibodies for pemphigus bulgaris?






43. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






44. Name two endogenous pyrogens






45. How does the alternative pathway lead to MAC activation?






46. What is chronic mucocutaneous candidiasis d/t?






47. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






48. What is the receptor for EBV? On what cells is that located?






49. What are howell jolly bodies?






50. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?