Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. IgG...






2. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






3. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






4. Which disease is associated with B8?






5. What is oprelevkin? and What is it used for?






6. What is the pathogenesis of a candida skin test?






7. What do mature naive B lymphocytes express?






8. What lymph node drains the rectum (above the pectinate line)?






9. What are the main symptoms of B cell immunodeficiencies?






10. which antibody is involved in the primary response or immediate response to an antigen?






11. What is the main cytokine released by T cells? What does it do






12. Which diseases are associated with DR2?






13. which interleukin receptor is required for NK development? activation?






14. Which type of selection of thymic development provides central tolerance?






15. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






16. What is the receptor for EBV? On what cells is that located?






17. The alternative pathway is the only constutively...






18. What is an example of a parasite showing antigenic variation?






19. What is thrombopoietin used for?






20. Which is the most abundant antibody in blood?






21. What is filgrastim and sargramostim? and What is it used for?






22. How is i Th1 helper cell inhibited?






23. What is the general structure of an Ab?






24. What are the autoantibodies for polymyositis and dermatomyositis?






25. What are the cell surface proteins for Macrophages? which two are for opsonins?






26. What does interferon gamma do to be antiviral?






27. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






28. What are the two signals to kill for NK cells?






29. What is the autoantibody for SLE that is nonspecific? Specific?






30. What is the common variable immunodeficiency ? How is it different from Brutons?






31. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






32. What are the autoantibodies for other vasculitides?






33. Which cytokines do Th2 release and For what?






34. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






35. which of the transplant rejections is antibody mediated? why does it occur?






36. what bacteria are a splenectomy patient most susceptible to? why?






37. What is immune complex disease? give an example.






38. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






39. What is the main function of IL 12? other than macrophages who else can release IL 12?






40. Complements are...






41. Give an example of someone who could get hyperacute transplant rejection.






42. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






43. are Th cells involved in trapping of antigens of endotoxin/LPS?






44. What lymph node drains the sigmoid colon?






45. Which is the main antibody that provides passive immunity to infants?






46. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






47. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






48. which type of immunity is slow but long lasting? as opposed to...






49. What is the presentation of Brutons agammaglobulinemia?






50. IgM can exist as a _______ also