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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name two endogenous pyrogens






2. describe the pathogenesis of delayed type IV hypersensitivity






3. What is chronic mucocutaneous candidiasis d/t?






4. What is the presentation of Brutons agammaglobulinemia?






5. What is the toxicity of muromonab?






6. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






7. What links the adaptive and innate immunity?






8. What is a factor that is a predictor for a bad transplantation?






9. What are the T cell functions?






10. What are the two signals required for Th1 cells? what happens after then activated?






11. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






12. Which disease is associated with DR7?






13. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






14. What are C1 - C2 - C3 - C4 important for?






15. IgM can exist as a _______ also






16. What are the autoantibodies for pemphigus bulgaris?






17. What does IL 4 do?






18. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






19. What are the autoantibodies for autoimmune hepatitis?






20. what characterizes an arthus reaction?






21. which interleukin receptor is required for NK development? activation?






22. Describe the complement independent Type II hypersenstivity reaction. Give an example.






23. where do somatic hypermutation and class switching occur?






24. What lymph node drains the lateral side of the dorsum of the foot?






25. What are the symptoms of serum sickness?






26. What is the presentation of scid? treatment?






27. What is the general structure of an Ab?






28. What happens in a deficiency of C3?






29. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






30. Other than stimulating fever - what else does IL 6 do?






31. What lymph node drains the breast?






32. What is oprelevkin? and What is it used for?






33. Which disease is associated with HLA A3?






34. To what disease do the autoantibodies to IgG (rheumatoid factor)?






35. what cell surface proteins are on all APCs?






36. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






37. What is recomb alpha interferon used for?






38. What is the most common selective Ig deficiency? What is the presentation?






39. What is the mechanism for sirolimus? what else it known as?






40. other than eat and bite RBCs what else do Macrophages of spleen do>






41. Describe the capsular structure of a lymph node; What are the functions of the LN?






42. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






43. What are the autoantibodies for other vasculitides?






44. What lymph node drains the rectum (above the pectinate line)?






45. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






46. where do NK cells develop?






47. What is the marginal zone of the spleen? what happens there?






48. The Fc region is found on the...






49. What are the labs in brutons agammaglobulinemia?






50. can igG cross the placenta?