Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is an example of a parasite showing antigenic variation?






2. What is the presentation of Brutons agammaglobulinemia?






3. can igG cross the placenta?






4. What is three common causes of severe combined immunodef? What is the result of all three?






5. From where do cytokines come from?






6. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






7. Which disease is associated with DR7?






8. What are the PALS?






9. What is colostrum?






10. What is the receptor for EBV? On what cells is that located?






11. What are the autoantibodies for graves?






12. What are some catalase positive organisms?






13. Which disease is associated with B8?






14. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






15. What are howell jolly bodies?






16. What is oprelevkin? and What is it used for?






17. What lymph node drains the rectum (above the pectinate line)?






18. The pathogenesis of contact dermatitis is ________ hypersensitivity






19. How is sirolimus different from tacrolimus?






20. ________ regulate the cell mediated response.






21. What is immune complex disease? give an example.






22. In thymic development - What is the positive selection? negative selections?






23. describe the classic complement pathway.






24. describe the pathogenesis of delayed type IV hypersensitivity






25. What is the pathology seen in chronic transplant rejection?






26. What is the pathogenesis of a candida skin test?






27. Name two endogenous pyrogens






28. What is muromonab - CD3 (OKT3)






29. What is a factor that is a predictor for a bad transplantation?






30. What are the autoantibodies for goodpastures syndrome?






31. which antibodies can bind complement?






32. Name 5 ways Antibody diversity is generated?






33. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






34. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






35. Type Iv hypersensitivity is...






36. What does IL 2 do?






37. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






38. What are the autoantibodies for pemphigus bulgaris?






39. IgG...






40. Monomer in circulation - ___ when secreted






41. What are the main cell surface proteins on B cells?






42. What is digoxin immune Fab used for?






43. What are the autoantibodies for sjorgens syndrome?






44. What is the clinical use for sirolimus? what should you combine it with?






45. What are the labs in brutons agammaglobulinemia?






46. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






47. What are the two signals to kill for NK cells?






48. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






49. What is passive immunity?






50. What are the autoantibodies for autoimmune hepatitis?