Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is a factor that is a predictor for a bad transplantation?






2. What does granulysin do?






3. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






4. which antibody activate mast cells - basophils - and eosinophils?






5. T/F B cells do not require a second signal






6. What are the autoantibodies for systemic sclerosis?






7. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






8. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






9. What is recomb beta interferon used for?






10. What is the presentation of common variable immunodef? and What are the labs?






11. Monomer in circulation - ___ when secreted






12. What does IL 2 do?






13. What are the autoantibodies for pernicious anemia?






14. To what portion of the Antibody do the complements bind?






15. What lymph node drains the anal canal (below the pectinate line)?






16. other than mediating shock - what else does TNF alpha do? who releases it mainly?






17. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






18. What are four results of a splenectomy?






19. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






20. What lymph node drains the testes?






21. What lymph node drains the duodenum - jejunum?






22. What does IL 4 do?






23. where do NK cells develop?






24. Which disease is associated withB B27?






25. What does Interferon alpha and beta do? how?






26. What lymph node drains the lateral side of the dorsum of the foot?






27. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






28. Complements are...






29. The two heavy chains of an antibody contribute to the...






30. What are the autoantibodies for Mixed connective tissue disease?






31. What is serum sickness? give an example.






32. What cytokines are released by Th1 cells?






33. What is the pathogenesis of a candida skin test?






34. What is the pathogenesis of a hypersensitivity reaction?






35. Leukocyte adhesion defect presents with...






36. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






37. What is the receptor for EBV? On what cells is that located?






38. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






39. What lymph node drains the rectum (above the pectinate line)?






40. What are the autoantibodies for Celiac disease?






41. which antibodies prevent antigens from binding mucosal surfaces?






42. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






43. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






44. What is the autoantibody for SLE that is nonspecific? Specific?






45. What is the most common example of passive immunity?






46. what will NK cells do to cells covered in IgG Ab? why?






47. What does IgA pick up from epithelial cells before being secreted?






48. What do multimeric antibodies require for assembly?






49. What is the white pulp of the spleen?






50. What type of fenestrations are found in the red pulp of the spleen?