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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






2. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






3. Complements are...






4. What does interferon gamma do to be antiviral?






5. What is the main function of IL 12? other than macrophages who else can release IL 12?






6. Leukocyte adhesion defect presents with...






7. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






8. What does granulysin do?






9. What is serum sickness? give an example.






10. What kinds of receptors activate innate immunity?






11. What is colostrum?






12. What does IL 10 do? who is secreted by?






13. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






14. What is the presentation of scid? treatment?






15. which cytokine inhibits TH2 cells? secreted by who?






16. What are the autoantibodies for polymyositis and dermatomyositis?






17. What are the three types of APCs?






18. What is the receptor for EBV? On what cells is that located?






19. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






20. What lymph node drains the sigmoid colon?






21. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






22. What does interferon gamma do? What two type of cells does it attack mostly?






23. other than mediating shock - what else does TNF alpha do? who releases it mainly?






24. What is filgrastim and sargramostim? and What is it used for?






25. What happens in a secondary follicle?






26. What is the presentation of hyperIgM syndrome?






27. which antibodies prevent antigens from binding mucosal surfaces?






28. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






29. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






30. Which HLA's are included in MHC I? MHC II?

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31. What are the two signals required for T cells? what happens after?






32. The alternative pathway is the only constutively...






33. What is recomb alpha interferon used for?






34. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






35. Which is the main antibody in the delayed or secondary response to an antigen?






36. What cytokines are released by Th1 cells?






37. IgE has the ___________ in the serum






38. What are the autoantibodies for wegeners granulomatosis?






39. Which disease is associated with DR3?






40. What is digoxin immune Fab used for?






41. What are the two signals required for Th1 cells? what happens after then activated?






42. What are the two signals required for B cell class switching? Which is the second signal?






43. Which diseases are associated with DR2?






44. From where do cytokines come from?






45. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






46. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






47. What are the autoantibodies for hashimotos?






48. are Th cells involved in trapping of antigens of endotoxin/LPS?






49. What happens in a deficiency of C3?






50. The secondary follicles have __________; primary follicles are dense