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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what cell surface marker is used for NK cells as it is unique to them?






2. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






3. What lymph node drains the anal canal (below the pectinate line)?






4. Which antibody mediates immunity to worms? how?






5. What is a factor that is a predictor for a bad transplantation?






6. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






7. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






8. How is the thymus organized? what happens in each section?






9. In general What are T cells good for?






10. What is digoxin immune Fab used for?






11. What is filgrastim and sargramostim? and What is it used for?






12. which antibodies can bind complement?






13. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






14. Describe the Mannose Lectin pathway






15. What is the common variable immunodeficiency ? How is it different from Brutons?






16. What are the main symptoms of T cell immunodeficiencies?






17. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






18. What is the toxicity of muromonab?






19. where do somatic hypermutation and class switching occur?






20. What is a type I hypersensitivity reaction? What is atopic?






21. What are the main cell surface proteins on B cells?






22. is IgM an opsonizer?






23. What is the cause of thymic aplasia? What is its presentation? What are the labs?






24. What are the autoantibodies for Celiac disease?






25. which of the transplant rejections is antibody mediated? why does it occur?






26. What is hereditary angioedema? What are the C3 levels?






27. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






28. What is the main cytokine that activates eosinophils?






29. Type Iv hypersensitivity is...






30. What are the two signals required for B cell class switching? Which is the second signal?






31. From where do cytokines come from?






32. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






33. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






34. which of the hypersensitivity reactions is not Ab mediated?






35. What are some sinopulmonary infections?






36. What are superantigens? give two examples.






37. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






38. Type IV hypersensitivity is i...






39. what will NK cells do to cells covered in IgG Ab? why?






40. How do you test for chronic granulomatous disease?






41. are Th cells involved in trapping of antigens of endotoxin/LPS?






42. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






43. What does IL 5 do?






44. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






45. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






46. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






47. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






48. IgM can fix complement but...






49. Give three examples of bacteria that use antigenic variation and how.






50. other than eat and bite RBCs what else do Macrophages of spleen do>







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