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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the PALS?






2. Which cytokines do Th2 release and For what?






3. What can cause a lymph node enlargement?






4. What is the pathogenesis of acute transplant rejection? When does it occur?






5. What is the main function of IL 8?






6. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






7. what cell surface proteins are on all APCs?






8. What is the pathology of acute transplant rejection? is it reversible?






9. What does granzyme do? who secretes it?






10. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






11. What are four results of a splenectomy?






12. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






13. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






14. What are the main Cell surface proteins on T cells?






15. IgG...






16. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






17. What lymph node drains the anal canal (below the pectinate line)?






18. What are the function of B cells?






19. Which disease is associated with B8?






20. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






21. what cytokine does basophils secrete?






22. What is the marginal zone of the spleen? what happens there?






23. T/F B cells do not require a second signal






24. which cells have more complete tolerance - B or T cells?






25. IgM can fix complement but...






26. are Th cells involved in trapping of antigens of endotoxin/LPS?






27. What are the autoantibodies for type I diabetes mellitus?






28. What is colostrum?






29. What is the presentation of scid? treatment?






30. What bugs can actually infect the lymph node itself?






31. IgM can exist as a _______ also






32. What are the autoantibodies for autoimmune hepatitis?






33. How fast does it occur?






34. What are the two signals required for Th1 cells? what happens after then activated?






35. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






36. What is the white pulp of the spleen?






37. What is the treatment of acute transplant rejection?






38. What is digoxin immune Fab used for?






39. What lymph node drains the testes?






40. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






41. What are the autoantibodies for Celiac disease?






42. What is recomb gamma interferon used for?






43. Other than stimulating fever - what else does IL 6 do?






44. The idiotype; the Fc portion determines the...






45. What are the autoantibodies for Mixed connective tissue disease?






46. which antibodies prevent antigens from binding mucosal surfaces?






47. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






48. What are the autoantibodies for wegeners granulomatosis?






49. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






50. What is the toxicity of muromonab?