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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is a type I hypersensitivity reaction? What is atopic?






2. What is muromonab - CD3 (OKT3)






3. Type Iv hypersensitivity is...






4. What is the presentation of scid? treatment?






5. What is immune complex disease? give an example.






6. What links the adaptive and innate immunity?






7. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






8. which antibodies prevent antigens from binding mucosal surfaces?






9. What are the autoantibodies for drug induced lupus?






10. What is the late phase reaction of anaphylaxis allergy? what mediates it?






11. What are target cells?






12. How fast does it occur?






13. What cytokines are released by Th1 cells?






14. What is the white pulp of the spleen?






15. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






16. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






17. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






18. What is the pathogenesis of a hypersensitivity reaction?






19. Which MHC presents intracellular peptides? how so?






20. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






21. Give an example of someone who could get hyperacute transplant rejection.






22. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






23. What is the main function of interferons?






24. What is the main cytokine that activates eosinophils?






25. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






26. What is the toxicity of muromonab?






27. which antibodies can bind complement?






28. which cytokine inhibits TH2 cells? secreted by who?






29. The idiotype; the Fc portion determines the...






30. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






31. What are howell jolly bodies?






32. What is oprelevkin? and What is it used for?






33. What is the treatment of acute transplant rejection?






34. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






35. Which diseases are associated with DR5?






36. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






37. What are the PALS?






38. What are the three types of lymphocytes?






39. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






40. Which antibodies can be multimeric?






41. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






42. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






43. Which type of selection of thymic development provides central tolerance?






44. What is the autoantibody for SLE that is nonspecific? Specific?






45. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






46. What lymph node drains the thigh?






47. Monomer in circulation - ___ when secreted






48. What are C1 - C2 - C3 - C4 important for?






49. IgM can fix complement but...






50. What are the autoantibodies for type I diabetes mellitus?