Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






2. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






3. What are the two signals required for T cells? what happens after?






4. Which MHC presents intracellular peptides? how so?






5. What are the labs in brutons agammaglobulinemia?






6. The idiotype; the Fc portion determines the...






7. which type of immunity is slow but long lasting? as opposed to...






8. which antibodies can bind complement?






9. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






10. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






11. What is the pathogenesis of a hypersensitivity reaction?






12. What is immune complex disease? give an example.






13. How is i Th1 helper cell inhibited?






14. What are the autoantibodies for hashimotos?






15. Which disease is associated with HLA A3?






16. Which disease is associated with B8?






17. ________ regulate the cell mediated response.






18. What are howell jolly bodies?






19. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






20. Name two endogenous pyrogens






21. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






22. What are MHC's necessary for? By themselves?






23. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






24. What is the pathogenesis of a candida skin test?






25. Which antibody mediates immunity to worms? how?






26. What is oprelevkin? and What is it used for?






27. Which helper T cells' development is induced by IL 4? IL 12?






28. What are the autoantibodies for primary biliary cirrhosis?






29. What cytokines are released by Th1 cells?






30. What are the autoantibodies for systemic sclerosis?






31. What are the two signals required for Th1 cells? what happens after then activated?






32. In general What are T cells good for?






33. What is the toxicity of azathioprine?






34. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






35. Which is the main antibody that provides passive immunity to infants?






36. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






37. The secondary follicles have __________; primary follicles are dense






38. are Th cells involved in trapping of antigens of endotoxin/LPS?






39. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






40. What is the toxicity of muromonab?






41. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






42. Which diseases are associated with DR5?






43. What are the autoantibodies for polymyositis and dermatomyositis?






44. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






45. What is chronic mucocutaneous candidiasis d/t?






46. The ______ in the BM are DN - the DP are in the cortex of thymus






47. What is hereditary angioedema? What are the C3 levels?






48. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






49. What are the mediators that mast cells release?






50. Describe the Mannose Lectin pathway