Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






2. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






3. IgE has the ___________ in the serum






4. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






5. hat is the presentation of Jobs syndrome or Hyper IgE?






6. What is the presentation of scid? treatment?






7. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






8. The two heavy chains of an antibody contribute to the...






9. What are the main cell surface proteins on B cells?






10. Type Iv hypersensitivity is...






11. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






12. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






13. What is the mechanism for sirolimus? what else it known as?






14. what prevents NK cells from killing normal cells if their default is to kill?






15. What are the PALS?






16. What is the main cytokine released by T cells? What does it do






17. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






18. What are target cells?






19. How is the antigen loaded onto a MHC II?






20. What is the clinical use of Muromonab?






21. What is the late phase reaction of anaphylaxis allergy? what mediates it?






22. What are the labs in brutons agammaglobulinemia?






23. What are the autoantibodies for drug induced lupus?






24. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






25. what characterizes an arthus reaction?






26. What is the pathogenesis of HyperIgE syndrome? What are the labs?






27. are Th cells involved in trapping of antigens of endotoxin/LPS?






28. What are the autoantibodies for hashimotos?






29. What links the adaptive and innate immunity?






30. What type of side chains are found on Fc region of an antibody?






31. What portion of the lymph node is not well developed in DiGeorge Syndrome?






32. What is recomb beta interferon used for?






33. what happens in a deficiency of C1 esterase inhibitor? DAF?






34. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






35. Which antibody mediates immunity to worms? how?






36. Give three examples of bacteria that use antigenic variation and how.






37. What lymph node drains the thigh?






38. What are some catalase positive organisms?






39. when can graft versus host disease? What is the result?






40. other than eat and bite RBCs what else do Macrophages of spleen do>






41. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






42. What is immune complex disease? give an example.






43. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






44. What are the main symptoms of B cell immunodeficiencies?






45. Which disease is associated with HLA A3?






46. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






47. other than C3a - what other complement acts as an anaphyloxin?






48. What do multimeric antibodies require for assembly?






49. What is the toxicity of muromonab?






50. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?