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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






2. Which are the only two antiinflammatory cytokines?






3. What are the autoantibodies for autoimmune hepatitis?






4. Which disease is associated withB B27?






5. which antibodies can bind complement?






6. What do multimeric antibodies require for assembly?






7. Describe complement dependent Type II hypersensitivity. Give an example.






8. What does IL 4 do?






9. What is the receptor for EBV? On what cells is that located?






10. What are the main symptoms of T cell immunodeficiencies?






11. What is thrombopoietin used for?






12. What is the common variable immunodeficiency ? How is it different from Brutons?






13. what results in symptoms of shock in an acute hemolytic transfusion reaction?






14. Which is the main antibody in the delayed or secondary response to an antigen?






15. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






16. What are the main Cell surface proteins on T cells?






17. What are C1 - C2 - C3 - C4 important for?






18. What is three common causes of severe combined immunodef? What is the result of all three?






19. So antibodies are the effectors for the humoral response. List some of their functions.






20. How is the antigen loaded onto a MHC II?






21. what prevents NK cells from killing normal cells if their default is to kill?






22. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






23. other than C3a - what other complement acts as an anaphyloxin?






24. Which helper T cells' development is induced by IL 4? IL 12?






25. What is the main cytokine released by T cells? What does it do






26. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






27. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






28. How is sirolimus different from tacrolimus?






29. is IgM an opsonizer?






30. What lymph node drains the lateral side of the dorsum of the foot?






31. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






32. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






33. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






34. What are superantigens? give two examples.






35. The lymphocytes are ________ origin






36. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






37. which cells have more complete tolerance - B or T cells?






38. Which HLA's are included in MHC I? MHC II?






39. What are some catalase positive organisms?






40. What are the autoantibodies for systemic sclerosis?






41. what happens in a deficiency of C1 esterase inhibitor? DAF?






42. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






43. What are the autoantibodies for other vasculitides?






44. What is the most common example of passive immunity?






45. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






46. Other than stimulating fever - what else does IL 6 do?






47. What does granzyme do? who secretes it?






48. Which is the main antibody that provides passive immunity to infants?






49. What lymph node drains the stomach?






50. What lymph node drains the breast?