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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. So antibodies are the effectors for the humoral response. List some of their functions.






2. What are the autoantibodies for goodpastures syndrome?






3. What is the toxicity of azathioprine?






4. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






5. What are the main symptoms of T cell immunodeficiencies?






6. What is the presentation of hyperIgM syndrome?






7. other than eat and bite RBCs what else do Macrophages of spleen do>






8. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






9. What is chronic mucocutaneous candidiasis d/t?






10. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






11. What does IL 2 do?






12. Which is the main antibody that provides passive immunity to infants?






13. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






14. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






15. What are the major functions of Antibodies?






16. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






17. what results in symptoms of shock in an acute hemolytic transfusion reaction?






18. Leukocyte adhesion defect presents with...






19. Which antibodies can be multimeric?






20. What is the main function of interferons?






21. What lymph node drains the breast?






22. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






23. Type IV hypersensitivity is i...






24. What are the autoantibodies for pernicious anemia?






25. What are the autoantibodies for graves?






26. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






27. What are MHC's necessary for? By themselves?






28. What are the three types of APCs?






29. What is the general structure of an Ab?






30. What type of fenestrations are found in the red pulp of the spleen?






31. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






32. Which helper T cells' development is induced by IL 4? IL 12?






33. What is the receptor for EBV? On what cells is that located?






34. what prevents NK cells from killing normal cells if their default is to kill?






35. ________ regulate the cell mediated response.






36. What is passive immunity?






37. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






38. What is the toxicity of muromonab?






39. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






40. What are the two signals required for Th1 cells? what happens after then activated?






41. What is the presentation of Brutons agammaglobulinemia?






42. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






43. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






44. In general What are T cells good for?






45. What do multimeric antibodies require for assembly?






46. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






47. What lymph node drains the sigmoid colon?






48. What are the autoantibodies for systemic sclerosis?






49. Monomer in circulation - ___ when secreted






50. what mediates the type II hypersensitivity? What are the two different methods?