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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is three common causes of severe combined immunodef? What is the result of all three?






2. What does IL 5 do?






3. other than eat and bite RBCs what else do Macrophages of spleen do>






4. What do multimeric antibodies require for assembly?






5. In thymic development - What is the positive selection? negative selections?






6. what secretes IL 4?






7. Only the _______ contribute to the Fc region






8. What lymph node drains the sigmoid colon?






9. IgM can exist as a _______ also






10. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






11. Which antibody mediates immunity to worms? how?






12. Which HLA's are included in MHC I? MHC II?

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13. What are the autoantibodies for graves?






14. What links the adaptive and innate immunity?






15. describe the pathogenesis of delayed type IV hypersensitivity






16. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






17. What are some sinopulmonary infections?






18. What does CD16 on NK cells do?






19. For which toxins are preformed antibodies (passive) given?






20. what prevents NK cells from killing normal cells if their default is to kill?






21. What is the toxicity of azathioprine?






22. What is anergy? why does this occur?






23. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






24. which antibodies can bind complement?






25. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






26. What lymph node drains the scrotum?






27. What are the autoantibodies for systemic sclerosis?






28. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






29. What kinds of receptors activate innate immunity?






30. What is serum sickness? give an example.






31. What can cause a lymph node enlargement?






32. What are the PALS?






33. What are the major functions of Antibodies?






34. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






35. What are the labs in brutons agammaglobulinemia?






36. What is the mechanism for sirolimus? what else it known as?






37. What is the pathogenesis of acute transplant rejection? When does it occur?






38. How is i Th1 helper cell inhibited?






39. What is the main cytokine that activates eosinophils?






40. __________ are a part of the innate system.






41. T/F B cells do not require a second signal






42. what characterizes an arthus reaction?






43. What is the marginal zone of the spleen? what happens there?






44. which cells have more complete tolerance - B or T cells?






45. Which disease is associated with DR3?






46. How is sirolimus different from tacrolimus?






47. Which cytokines do Th2 release and For what?






48. What is the toxicity of muromonab?






49. Which diseases are associated with DR5?






50. What is chronic mucocutaneous candidiasis d/t?