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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do you test for chronic granulomatous disease?






2. So antibodies are the effectors for the humoral response. List some of their functions.






3. Only the _______ contribute to the Fc region






4. in which immunodef order do you see a lot of pus? no pus?






5. What is the late phase reaction of anaphylaxis allergy? what mediates it?






6. which type of immunity is slow but long lasting? as opposed to...






7. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






8. What is the autoantibody for SLE that is nonspecific? Specific?






9. What is the main function of IL 12? other than macrophages who else can release IL 12?






10. What is serum sickness? give an example.






11. What are the three types of lymphocytes?






12. How fast does it occur?






13. what characterizes an arthus reaction?






14. Describe the complement independent Type II hypersenstivity reaction. Give an example.






15. Which disease is associated with B8?






16. What is the main cytokine released by T cells? What does it do






17. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






18. From where do cytokines come from?






19. are Th cells involved in trapping of antigens of endotoxin/LPS?






20. What are the autoantibodies for wegeners granulomatosis?






21. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






22. What is the presentation of hyperIgM syndrome?






23. What is the pathology seen in chronic transplant rejection?






24. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






25. How is sirolimus different from tacrolimus?






26. IgM can exist as a _______ also






27. What is Aldesleukin? What is it used for






28. where do NK cells develop?






29. What does IL 2 do?






30. For which toxins are preformed antibodies (passive) given?






31. Which HLA's are included in MHC I? MHC II?

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32. What is the pathogenesis of a candida skin test?






33. What are the autoantibodies for Mixed connective tissue disease?






34. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






35. What is the pathogenesis of a hypersensitivity reaction?






36. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






37. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






38. How is i Th1 helper cell inhibited?






39. What is recomb gamma interferon used for?






40. Name 5 ways Antibody diversity is generated?






41. What is an example of a parasite showing antigenic variation?






42. What can cause a lymph node enlargement?






43. What kinds of receptors activate innate immunity?






44. What lymph node drains the lateral side of the dorsum of the foot?






45. describe the classic complement pathway.






46. what prevents NK cells from killing normal cells if their default is to kill?






47. How is the thymus organized? what happens in each section?






48. What lymph node drains the testes?






49. What is immune complex disease? give an example.






50. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?