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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name 5 ways Antibody diversity is generated?






2. What are the symptoms of serum sickness?






3. What portion of the lymph node is not well developed in DiGeorge Syndrome?






4. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






5. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






6. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






7. Give three examples of bacteria that use antigenic variation and how.






8. What is the treatment of acute transplant rejection?






9. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






10. What is three common causes of severe combined immunodef? What is the result of all three?






11. Other than stimulating fever - what else does IL 6 do?






12. What is the main cytokine released by T cells? What does it do






13. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






14. What are four results of a splenectomy?






15. What are MHC's necessary for? By themselves?






16. What does it mean if there are igM in the serum at birth?






17. IgE has the ___________ in the serum






18. How does the alternative pathway lead to MAC activation?






19. What are C1 - C2 - C3 - C4 important for?






20. Which disease is associated with HLA A3?






21. What is the presentation of hyperIgM syndrome?






22. What is Aldesleukin? What is it used for






23. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






24. is IgM an opsonizer?






25. What is the main function of interferons?






26. Type IV hypersensitivity is i...






27. What is thrombopoietin used for?






28. What is anergy? why does this occur?






29. what characterizes an arthus reaction?






30. what ensure that a memory response is generated?






31. What lymph node drains the scrotum?






32. Describe the complement independent Type II hypersenstivity reaction. Give an example.






33. What lymph node drains the stomach?






34. What are the two signals to kill for NK cells?






35. What is recomb alpha interferon used for?






36. What are some sinopulmonary infections?






37. what bacteria are a splenectomy patient most susceptible to? why?






38. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






39. What are the three types of lymphocytes?






40. How is the thymus organized? what happens in each section?






41. What are some catalase positive organisms?






42. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






43. What is the marginal zone of the spleen? what happens there?






44. What are the autoantibodies for wegeners granulomatosis?






45. What is an example of a parasite showing antigenic variation?






46. How do you test for type III hypersensitivity?






47. __________ are a part of the innate system.






48. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






49. So antibodies are the effectors for the humoral response. List some of their functions.






50. What is the pathogenesis of acute transplant rejection? When does it occur?