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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what cell surface proteins are on all APCs?






2. Describe the Mannose Lectin pathway






3. which of the transplant rejections is antibody mediated? why does it occur?






4. What are the autoantibodies for goodpastures syndrome?






5. What does Interferon alpha and beta do? how?






6. What are MHC's necessary for? By themselves?






7. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






8. What is three common causes of severe combined immunodef? What is the result of all three?






9. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






10. Which MHC presents intracellular peptides? how so?






11. What are the cell surface proteins on NK cells?






12. What are some catalase positive organisms?






13. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






14. What are the major functions of Antibodies?






15. What is thrombopoietin used for?






16. IgG...






17. Which HLA's are included in MHC I? MHC II?

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18. In thymic development - What is the positive selection? negative selections?






19. describe the pathogenesis of delayed type IV hypersensitivity






20. Which disease is associated with DR7?






21. To what portion of the Antibody do the complements bind?






22. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






23. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






24. What are the three types of lymphocytes?






25. What are the T cell functions?






26. what will NK cells do to cells covered in IgG Ab? why?






27. What are the autoantibodies for Celiac disease?






28. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






29. What kinds of receptors activate innate immunity?






30. What are the main symptoms of B cell immunodeficiencies?






31. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






32. What is the presentation of common variable immunodef? and What are the labs?






33. other than C3a - what other complement acts as an anaphyloxin?






34. What lymph node drains the duodenum - jejunum?






35. Which is the main antibody that provides passive immunity to infants?






36. What is recomb alpha interferon used for?






37. What is the pathogenesis of acute transplant rejection? When does it occur?






38. which cells have more complete tolerance - B or T cells?






39. What is chronic mucocutaneous candidiasis d/t?






40. How is the thymus organized? what happens in each section?






41. A lymph node is a ________ lymphoid organ.






42. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






43. What is the main function of TNF alpha? How does it do this?






44. which antibodies prevent antigens from binding mucosal surfaces?






45. Which is the main antibody in the delayed or secondary response to an antigen?






46. What are the autoantibodies for primary biliary cirrhosis?






47. What does CD16 on NK cells do?






48. What is the main cytokine that activates eosinophils?






49. What is serum sickness? give an example.






50. What does IL 10 do? who is secreted by?