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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which of the hypersensitivity reactions is not Ab mediated?






2. What is the autoantibody for SLE that is nonspecific? Specific?






3. what ensure that a memory response is generated?






4. What does IL 4 do?






5. The idiotype; the Fc portion determines the...






6. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






7. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






8. What does IL 10 do? who is secreted by?






9. IgM can exist as a _______ also






10. How is sirolimus different from tacrolimus?






11. What type of fenestrations are found in the red pulp of the spleen?






12. can igG cross the placenta?






13. What kinds of receptors activate innate immunity?






14. What is the pathology of acute transplant rejection? is it reversible?






15. What are the autoantibodies for myasthenia gravis?






16. What are the labs in brutons agammaglobulinemia?






17. Which type of selection of thymic development provides central tolerance?






18. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






19. What is the presentation of scid? treatment?






20. Monomer in circulation - ___ when secreted






21. What are some catalase positive organisms?






22. What cytokines are released by Th1 cells?






23. What is the presentation of Brutons agammaglobulinemia?






24. What do multimeric antibodies require for assembly?






25. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






26. What are superantigens? give two examples.






27. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






28. What lymph node drains the breast?






29. which antibodies prevent antigens from binding mucosal surfaces?






30. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






31. What is the toxicity of muromonab?






32. The Fc region is found on the...






33. Describe the complement independent Type II hypersenstivity reaction. Give an example.






34. Name 5 ways Antibody diversity is generated?






35. what will NK cells do to cells covered in IgG Ab? why?






36. What lymph node drains the sigmoid colon?






37. What are the PALS?






38. What lymph node drains the thigh?






39. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






40. What are the autoantibodies for graves?






41. other than mediating shock - what else does TNF alpha do? who releases it mainly?






42. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






43. What is the pathogenesis of acute transplant rejection? When does it occur?






44. What is recomb beta interferon used for?






45. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






46. Leukocyte adhesion defect presents with...






47. What are the three types of APCs?






48. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






49. What is the receptor for EBV? On what cells is that located?






50. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?