Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is chronic mucocutaneous candidiasis d/t?






2. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






3. What is epo used for?






4. What is oprelevkin? and What is it used for?






5. what cell surface proteins are on all APCs?






6. what results in symptoms of shock in an acute hemolytic transfusion reaction?






7. which cells have more complete tolerance - B or T cells?






8. What are the autoantibodies for Celiac disease?






9. other than C3a - what other complement acts as an anaphyloxin?






10. The ______ in the BM are DN - the DP are in the cortex of thymus






11. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






12. What are the three types of APCs?






13. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






14. The pathogenesis of contact dermatitis is ________ hypersensitivity






15. Type Iv hypersensitivity is...






16. Complements are...






17. What are C1 - C2 - C3 - C4 important for?






18. What type of fenestrations are found in the red pulp of the spleen?






19. Which antibody mediates immunity to worms? how?






20. What are the T cell functions?






21. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






22. What is the receptor for EBV? On what cells is that located?






23. What is the most common selective Ig deficiency? What is the presentation?






24. What is the main function of interferons?






25. where do somatic hypermutation and class switching occur?






26. Describe complement dependent Type II hypersensitivity. Give an example.






27. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






28. when can graft versus host disease? What is the result?






29. Give three examples of bacteria that use antigenic variation and how.






30. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






31. Which type of selection of thymic development provides central tolerance?






32. What lymph node drains the duodenum - jejunum?






33. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






34. can igG cross the placenta?






35. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






36. which antibodies prevent antigens from binding mucosal surfaces?






37. What cytokines are released by Th1 cells?






38. Describe the complement independent Type II hypersenstivity reaction. Give an example.






39. Name the three opsonins






40. What is the most common example of passive immunity?






41. in which immunodef order do you see a lot of pus? no pus?






42. How fast does it occur?






43. What is the pathology seen in chronic transplant rejection?






44. Which disease is associated with B8?






45. How does igA cross the epithelium?






46. What does it mean if there are igM in the serum at birth?






47. What is thrombopoietin used for?






48. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






49. what bacteria are a splenectomy patient most susceptible to? why?






50. Monomer in circulation - ___ when secreted