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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which HLA's are included in MHC I? MHC II?

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2. The pathogenesis of contact dermatitis is ________ hypersensitivity






3. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






4. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






5. are Th cells involved in trapping of antigens of endotoxin/LPS?






6. What do mature naive B lymphocytes express?






7. What are the autoantibodies for autoimmune hepatitis?






8. What does granulysin do?






9. Name the three opsonins






10. What does interferon gamma do? What two type of cells does it attack mostly?






11. What is the toxicity of muromonab?






12. What are the symptoms of serum sickness?






13. What are the autoantibodies for primary biliary cirrhosis?






14. What are the T cell functions?






15. What is a type I hypersensitivity reaction? What is atopic?






16. other than C3a - what other complement acts as an anaphyloxin?






17. What is the mechanism for sirolimus? what else it known as?






18. What is recomb beta interferon used for?






19. What are the labs in brutons agammaglobulinemia?






20. What are MHC's necessary for? By themselves?






21. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






22. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






23. What are the autoantibodies for Celiac disease?






24. what cytokine does basophils secrete?






25. What is passive immunity?






26. IgE has the ___________ in the serum






27. How do you test for type III hypersensitivity?






28. What is the main cytokine that activates eosinophils?






29. What lymph node drains the scrotum?






30. which antibody is involved in the primary response or immediate response to an antigen?






31. can igG cross the placenta?






32. What is anergy? why does this occur?






33. What are the autoantibodies for systemic sclerosis?






34. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






35. What are the autoantibodies for pemphigus bulgaris?






36. What are the autoantibodies for Mixed connective tissue disease?






37. what secretes IL 4?






38. What are some sinopulmonary infections?






39. which cytokine inhibits TH2 cells? secreted by who?






40. Which type of selection of thymic development provides central tolerance?






41. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






42. What does IL 10 do? who is secreted by?






43. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






44. which antibodies prevent antigens from binding mucosal surfaces?






45. Which disease is associated with B8?






46. What is the autoantibody for SLE that is nonspecific? Specific?






47. What is the main function of TNF alpha? How does it do this?






48. What is the pathology of acute transplant rejection? is it reversible?






49. What are four results of a splenectomy?






50. What is the presentation of Brutons agammaglobulinemia?







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