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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Only the _______ contribute to the Fc region






2. The pathogenesis of contact dermatitis is ________ hypersensitivity






3. What are the major functions of Antibodies?






4. What does IL 4 do?






5. which type of immunity is slow but long lasting? as opposed to...






6. The MALT/GALT are not...






7. What is a type I hypersensitivity reaction? What is atopic?






8. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






9. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






10. From where do cytokines come from?






11. What are the autoantibodies for polymyositis and dermatomyositis?






12. What does IL 5 do?






13. other than mediating shock - what else does TNF alpha do? who releases it mainly?






14. What are the main Cell surface proteins on T cells?






15. The secondary follicles have __________; primary follicles are dense






16. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






17. How do you test for chronic granulomatous disease?






18. What lymph node drains the testes?






19. How is the thymus organized? what happens in each section?






20. What are the autoantibodies for Celiac disease?






21. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






22. What is oprelevkin? and What is it used for?






23. What are the autoantibodies for goodpastures syndrome?






24. Name the three opsonins






25. What are the autoantibodies for primary biliary cirrhosis?






26. which antibodies can bind complement?






27. What are the cell surface proteins on NK cells?






28. What are the mediators that mast cells release?






29. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






30. what prevents NK cells from killing normal cells if their default is to kill?






31. what will NK cells do to cells covered in IgG Ab? why?






32. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






33. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






34. What are the autoantibodies for graves?






35. What does it mean if there are igM in the serum at birth?






36. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






37. What is the main function of IL 8?






38. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






39. What lymph node drains the breast?






40. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






41. What kinds of receptors activate innate immunity?






42. can igG cross the placenta?






43. What is the main cytokine that activates eosinophils?






44. What are superantigens? give two examples.






45. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






46. What is the clinical use for azathioprine?






47. What are the autoantibodies for pemphigus bulgaris?






48. What are the labs in brutons agammaglobulinemia?






49. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






50. What are the autoantibodies for pernicious anemia?






Can you answer 50 questions in 15 minutes?



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