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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what results in symptoms of shock in an acute hemolytic transfusion reaction?






2. which antibody activate mast cells - basophils - and eosinophils?






3. What is immune complex disease? give an example.






4. Leukocyte adhesion defect presents with...






5. Describe the complement independent Type II hypersenstivity reaction. Give an example.






6. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






7. What are the major functions of Antibodies?






8. Which disease is associated withB B27?






9. What does IL 5 do?






10. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






11. What is the general structure of an Ab?






12. What does granzyme do? who secretes it?






13. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






14. The Fc region is found on the...






15. which antibody is involved in the primary response or immediate response to an antigen?






16. Which antibody mediates immunity to worms? how?






17. How do you test for type III hypersensitivity?






18. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






19. What happens in a deficiency of C3?






20. What does interferon gamma do? What two type of cells does it attack mostly?






21. What are superantigens? give two examples.






22. give an example of how influenza does a major antigenic shift.






23. How does complement link innate and adaptive?






24. From where do cytokines come from?






25. what prevents NK cells from killing normal cells if their default is to kill?






26. What are target cells?






27. What are some catalase positive organisms?






28. What are the symptoms of serum sickness?






29. What is recomb gamma interferon used for?






30. What is filgrastim and sargramostim? and What is it used for?






31. Describe complement dependent Type II hypersensitivity. Give an example.






32. What is a type I hypersensitivity reaction? What is atopic?






33. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






34. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






35. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






36. Which disease is associated with DR7?






37. What type of fenestrations are found in the red pulp of the spleen?






38. What does IL 4 do?






39. What does IL 10 do? who is secreted by?






40. What are the two signals to kill for NK cells?






41. What are the autoantibodies for graves?






42. So antibodies are the effectors for the humoral response. List some of their functions.






43. What are the two signals required for T cells? what happens after?






44. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






45. What is hereditary angioedema? What are the C3 levels?






46. Type IV hypersensitivity is i...






47. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






48. __________ are a part of the innate system.






49. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






50. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?