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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How is the thymus organized? what happens in each section?






2. What does IL 4 do?






3. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






4. The pathogenesis of contact dermatitis is ________ hypersensitivity






5. What are superantigens? give two examples.






6. Which is the most abundant antibody in blood?






7. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






8. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






9. What is colostrum?






10. What does interferon gamma do? What two type of cells does it attack mostly?






11. describe the classic complement pathway.






12. ________ regulate the cell mediated response.






13. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






14. what cell surface marker is used for NK cells as it is unique to them?






15. What is the defect in hyper IgM syndrome? What are the lab results?






16. What are the cell surface proteins on NK cells?






17. What are the two signals required for Th1 cells? what happens after then activated?






18. What lymph node drains the stomach?






19. What lymph node drains the thigh?






20. What links the adaptive and innate immunity?






21. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






22. What is the general structure of an Ab?






23. A lymph node is a ________ lymphoid organ.






24. What are the three types of APCs?






25. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






26. What is hereditary angioedema? What are the C3 levels?






27. What is three common causes of severe combined immunodef? What is the result of all three?






28. What is filgrastim and sargramostim? and What is it used for?






29. Which MHC presents intracellular peptides? how so?






30. which interleukin receptor is required for NK development? activation?






31. The alternative pathway is the only constutively...






32. which type of immunity is slow but long lasting? as opposed to...






33. What does IL 2 do?






34. what bacteria are a splenectomy patient most susceptible to? why?






35. Name the three opsonins






36. What are the autoantibodies for sjorgens syndrome?






37. What are the autoantibodies for systemic sclerosis?






38. What are the autoantibodies for autoimmune hepatitis?






39. Give an example of someone who could get hyperacute transplant rejection.






40. What are the main cell surface proteins on B cells?






41. Which disease is associated with DR3?






42. What is thrombopoietin used for?






43. Give three examples of bacteria that use antigenic variation and how.






44. What is recomb gamma interferon used for?






45. What are four results of a splenectomy?






46. Which cytokines do Th2 release and For what?






47. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






48. what cell surface proteins are on all APCs?






49. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






50. What are the autoantibodies for pernicious anemia?