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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the late phase reaction of anaphylaxis allergy? what mediates it?






2. What are the two signals required for B cell class switching? Which is the second signal?






3. What is hereditary angioedema? What are the C3 levels?






4. What is the pathogenesis of acute transplant rejection? When does it occur?






5. other than eat and bite RBCs what else do Macrophages of spleen do>






6. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






7. Type Iv hypersensitivity is...






8. What are four results of a splenectomy?






9. other than C3a - what other complement acts as an anaphyloxin?






10. What lymph node drains the lateral side of the dorsum of the foot?






11. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






12. What is serum sickness? give an example.






13. What is the most common example of passive immunity?






14. What is the clinical use for sirolimus? what should you combine it with?






15. What are the autoantibodies for drug induced lupus?






16. What are some sinopulmonary infections?






17. what will NK cells do to cells covered in IgG Ab? why?






18. give an example of how influenza does a major antigenic shift.






19. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






20. To what portion of the Antibody do the complements bind?






21. T/F B cells do not require a second signal






22. What are the autoantibodies for Celiac disease?






23. What is the most common selective Ig deficiency? What is the presentation?






24. which B and T cell disorder presents with specifically low IgM?






25. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






26. What are MHC's necessary for? By themselves?






27. which of the hypersensitivity reactions is not Ab mediated?






28. What is digoxin immune Fab used for?






29. what bacteria are a splenectomy patient most susceptible to? why?






30. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






31. How fast does it occur?






32. The ______ in the BM are DN - the DP are in the cortex of thymus






33. Which antibodies can be multimeric?






34. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






35. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






36. what cell surface proteins are on all APCs?






37. The MALT/GALT are not...






38. Only the _______ contribute to the Fc region






39. What lymph node drains the testes?






40. What is the main cytokine that activates eosinophils?






41. What lymph node drains the scrotum?






42. How is the thymus organized? what happens in each section?






43. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






44. What are the mediators that mast cells release?






45. What is an example of a parasite showing antigenic variation?






46. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






47. What are the two signals to kill for NK cells?






48. Which disease is associated with DR7?






49. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






50. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.