Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the treatment of acute transplant rejection?






2. Which is the main antibody that provides passive immunity to infants?






3. How is i Th1 helper cell inhibited?






4. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






5. Give three examples of bacteria that use antigenic variation and how.






6. Monomer in circulation - ___ when secreted






7. What does IL 5 do?






8. In general What are T cells good for?






9. What is oprelevkin? and What is it used for?






10. Which disease is associated with HLA A3?






11. So antibodies are the effectors for the humoral response. List some of their functions.






12. What are the main Cell surface proteins on T cells?






13. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






14. Complements are...






15. What are the autoantibodies for autoimmune hepatitis?






16. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






17. What cytokines to Th2 secrete?






18. when can graft versus host disease? What is the result?






19. What lymph node drains the sigmoid colon?






20. What are the two signals to kill for NK cells?






21. other than eat and bite RBCs what else do Macrophages of spleen do>






22. in which immunodef order do you see a lot of pus? no pus?






23. What is the white pulp of the spleen?






24. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






25. What are the autoantibodies for other vasculitides?






26. What is the presentation of Brutons agammaglobulinemia?






27. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






28. What do multimeric antibodies require for assembly?






29. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






30. From where do cytokines come from?






31. is IgM an opsonizer?






32. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






33. What does IL 2 do?






34. what mediates the type II hypersensitivity? What are the two different methods?






35. where do NK cells develop?






36. What is the marginal zone of the spleen? what happens there?






37. What does Interferon alpha and beta do? how?






38. are Th cells involved in trapping of antigens of endotoxin/LPS?






39. What are the T cell functions?






40. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






41. What does IgA pick up from epithelial cells before being secreted?






42. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






43. Other than stimulating fever - what else does IL 6 do?






44. What is the toxicity of muromonab?






45. Name the three opsonins






46. What is muromonab - CD3 (OKT3)






47. What lymph node drains the upper limb?






48. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






49. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






50. which B and T cell disorder presents with specifically low IgM?