Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What happens in a deficiency of C3?






2. To what disease do the autoantibodies to IgG (rheumatoid factor)?






3. What is anergy? why does this occur?






4. The two heavy chains of an antibody contribute to the...






5. What lymph node drains the breast?






6. How is the thymus organized? what happens in each section?






7. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






8. How does the alternative pathway lead to MAC activation?






9. Which are the only two antiinflammatory cytokines?






10. What is recomb beta interferon used for?






11. What is the main function of IL 8?






12. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






13. which antibodies prevent antigens from binding mucosal surfaces?






14. describe the classic complement pathway.






15. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






16. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






17. Which is the most abundant antibody in blood?






18. other than mediating shock - what else does TNF alpha do? who releases it mainly?






19. How does complement link innate and adaptive?






20. which of the hypersensitivity reactions is not Ab mediated?






21. How is the antigen loaded onto a MHC II?






22. The pathogenesis of contact dermatitis is ________ hypersensitivity






23. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






24. Complements are...






25. What are the autoantibodies for sjorgens syndrome?






26. What is chronic mucocutaneous candidiasis d/t?






27. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






28. Describe the complement independent Type II hypersenstivity reaction. Give an example.






29. What is hereditary angioedema? What are the C3 levels?






30. What are the autoantibodies for other vasculitides?






31. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






32. IgE has the ___________ in the serum






33. describe the pathogenesis of delayed type IV hypersensitivity






34. What is the main function of interferons?






35. what mediates the type II hypersensitivity? What are the two different methods?






36. what will NK cells do to cells covered in IgG Ab? why?






37. What are the autoantibodies for graves?






38. which antibodies can bind complement?






39. What can cause a lymph node enlargement?






40. What is a factor that is a predictor for a bad transplantation?






41. So antibodies are the effectors for the humoral response. List some of their functions.






42. What is the treatment of acute transplant rejection?






43. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






44. which B and T cell disorder presents with specifically low IgM?






45. What is the toxicity of muromonab?






46. other than C3a - what other complement acts as an anaphyloxin?






47. __________ are a part of the innate system.






48. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






49. which antibody is involved in the primary response or immediate response to an antigen?






50. What is the presentation of hyperIgM syndrome?