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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which HLA's are included in MHC I? MHC II?






2. which antibody is involved in the primary response or immediate response to an antigen?






3. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






4. What are the autoantibodies for hashimotos?






5. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






6. What lymph node drains the thigh?






7. are Th cells involved in trapping of antigens of endotoxin/LPS?






8. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






9. What is the cause of thymic aplasia? What is its presentation? What are the labs?






10. when can graft versus host disease? What is the result?






11. What are the two signals required for B cell class switching? Which is the second signal?






12. What are howell jolly bodies?






13. What is serum sickness? give an example.






14. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






15. what happens in a deficiency of C1 esterase inhibitor? DAF?






16. What are the T cell functions?






17. How is sirolimus different from tacrolimus?






18. what results in symptoms of shock in an acute hemolytic transfusion reaction?






19. What is the general structure of an Ab?






20. What is the pathogenesis of HyperIgE syndrome? What are the labs?






21. Complements are...






22. What does IL 4 do?






23. Which MHC presents intracellular peptides? how so?






24. IgE has the ___________ in the serum






25. What is the main cytokine released by T cells? What does it do






26. Which disease is associated with B8?






27. What is passive immunity?






28. What does interferon gamma do to be antiviral?






29. What are the autoantibodies for myasthenia gravis?






30. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






31. The two heavy chains of an antibody contribute to the...






32. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






33. The secondary follicles have __________; primary follicles are dense






34. where do NK cells develop?






35. Which diseases are associated with DR5?






36. can igG cross the placenta?






37. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






38. Monomer in circulation - ___ when secreted






39. What is colostrum?






40. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






41. What are the main symptoms of T cell immunodeficiencies?






42. What are the autoantibodies for Mixed connective tissue disease?






43. what cell surface proteins are on all APCs?






44. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






45. other than eat and bite RBCs what else do Macrophages of spleen do>






46. What are the cell surface proteins on NK cells?






47. To what portion of the Antibody do the complements bind?






48. What are the labs in brutons agammaglobulinemia?






49. What is oprelevkin? and What is it used for?






50. What are the cell surface proteins for Macrophages? which two are for opsonins?