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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How is i Th1 helper cell inhibited?

2. What does interferon gamma do? What two type of cells does it attack mostly?

3. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?

4. What lymph node drains the lateral side of the dorsum of the foot?

5. What are the labs in brutons agammaglobulinemia?

6. What does granzyme do? who secretes it?

7. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?

8. What is a type I hypersensitivity reaction? What is atopic?

9. which cells have more complete tolerance - B or T cells?

10. What are the autoantibodies for hashimotos?

11. What is the pathogenesis of HyperIgE syndrome? What are the labs?

12. Describe complement dependent Type II hypersensitivity. Give an example.

13. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?

14. IgM can exist as a _______ also

15. Which diseases are associated with DR4?

16. Describe the Mannose Lectin pathway

17. which type of immunity is slow but long lasting? as opposed to...

18. What lymph node drains the scrotum?

19. What lymph node drains the anal canal (below the pectinate line)?

20. A lymph node is a ________ lymphoid organ.

21. What is the presentation of hyperIgM syndrome?

22. What kinds of receptors activate innate immunity?

23. what secretes IL 4?

24. what bacteria are a splenectomy patient most susceptible to? why?

25. What are the main Cell surface proteins on T cells?

26. What does IgA pick up from epithelial cells before being secreted?

27. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?

28. What does CD16 on NK cells do?

29. What lymph node drains the rectum (above the pectinate line)?

30. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?

31. What does granulysin do?

32. is IgM an opsonizer?

33. What happens in a deficiency of C3?

34. Give an example of someone who could get hyperacute transplant rejection.

35. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?

36. What is the treatment of acute transplant rejection?

37. Give three examples of bacteria that use antigenic variation and how.

38. which interleukin receptor is required for NK development? activation?

39. Only the _______ contribute to the Fc region

40. What are the main symptoms of T cell immunodeficiencies?

41. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?

42. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?

43. What lymph node drains the testes?

44. what happens in a deficiency of C1 esterase inhibitor? DAF?

45. other than eat and bite RBCs what else do Macrophages of spleen do>

46. what ensure that a memory response is generated?

47. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?

48. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?

49. which antibody is involved in the primary response or immediate response to an antigen?

50. What are the two signals required for B cell class switching? Which is the second signal?