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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. ________ regulate the cell mediated response.






2. What are target cells?






3. what will NK cells do to cells covered in IgG Ab? why?






4. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






5. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






6. IgM can fix complement but...






7. What are the autoantibodies for hashimotos?






8. What is the main function of TNF alpha? How does it do this?






9. What is the main function of IL 8?






10. What is passive immunity?






11. How is i Th1 helper cell inhibited?






12. The ______ in the BM are DN - the DP are in the cortex of thymus






13. Complements are...






14. What are the two signals required for Th1 cells? what happens after then activated?






15. The secondary follicles have __________; primary follicles are dense






16. What are the autoantibodies for pernicious anemia?






17. What lymph node drains the rectum (above the pectinate line)?






18. Name the three opsonins






19. what ensure that a memory response is generated?






20. Give an example of someone who could get hyperacute transplant rejection.






21. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






22. which of the transplant rejections is antibody mediated? why does it occur?






23. What are the major functions of Antibodies?






24. What are the three types of lymphocytes?






25. What does interferon gamma do to be antiviral?






26. What is chronic mucocutaneous candidiasis d/t?






27. which type of immunity is slow but long lasting? as opposed to...






28. What are the autoantibodies for myasthenia gravis?






29. What can cause a lymph node enlargement?






30. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






31. What are C1 - C2 - C3 - C4 important for?






32. which cytokine inhibits TH2 cells? secreted by who?






33. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






34. What are the PALS?






35. What are some sinopulmonary infections?






36. The Fc region is found on the...






37. What bugs can actually infect the lymph node itself?






38. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






39. What does it mean if there are igM in the serum at birth?






40. Monomer in circulation - ___ when secreted






41. Which MHC presents intracellular peptides? how so?






42. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






43. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






44. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






45. How fast does it occur?






46. Which disease is associated with B8?






47. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






48. Which helper T cells' development is induced by IL 4? IL 12?






49. How is the antigen loaded onto a MHC II?






50. What are the autoantibodies for Mixed connective tissue disease?