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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for myasthenia gravis?






2. Name 5 ways Antibody diversity is generated?






3. Which diseases are associated with DR5?






4. Which type of selection of thymic development provides central tolerance?






5. What links the adaptive and innate immunity?






6. The MALT/GALT are not...






7. other than eat and bite RBCs what else do Macrophages of spleen do>






8. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






9. when can graft versus host disease? What is the result?






10. What are the autoantibodies for wegeners granulomatosis?






11. Which cytokines do Th2 release and For what?






12. What is a type I hypersensitivity reaction? What is atopic?






13. What bugs can actually infect the lymph node itself?






14. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






15. What is recomb beta interferon used for?






16. is IgM an opsonizer?






17. What kinds of receptors activate innate immunity?






18. __________ are a part of the innate system.






19. What are C1 - C2 - C3 - C4 important for?






20. What are the autoantibodies for polymyositis and dermatomyositis?






21. What does IgA pick up from epithelial cells before being secreted?






22. What are the two signals required for B cell class switching? Which is the second signal?






23. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






24. What are the mediators that mast cells release?






25. What lymph node drains the anal canal (below the pectinate line)?






26. Describe the Mannose Lectin pathway






27. What lymph node drains the stomach?






28. Which disease is associated with HLA A3?






29. IgM can fix complement but...






30. What does it mean if there are igM in the serum at birth?






31. What does IL 10 do? who is secreted by?






32. What is the toxicity of azathioprine?






33. What lymph node drains the thigh?






34. What is the presentation of Brutons agammaglobulinemia?






35. Which is the most abundant antibody in blood?






36. what ensure that a memory response is generated?






37. What is digoxin immune Fab used for?






38. What are the autoantibodies for systemic sclerosis?






39. What is the main cytokine released by T cells? What does it do






40. What are the autoantibodies for hashimotos?






41. What are the symptoms of serum sickness?






42. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






43. What are the autoantibodies for drug induced lupus?






44. In general What are T cells good for?






45. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






46. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






47. Name the three opsonins






48. The ______ in the BM are DN - the DP are in the cortex of thymus






49. Type IV hypersensitivity is i...






50. From where do cytokines come from?