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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






2. In general What are T cells good for?






3. Which diseases are associated with DR4?






4. What is the main cytokine released by T cells? What does it do






5. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






6. What are the major functions of Antibodies?






7. What are the main symptoms of T cell immunodeficiencies?






8. So antibodies are the effectors for the humoral response. List some of their functions.






9. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






10. Describe the capsular structure of a lymph node; What are the functions of the LN?






11. which antibodies can bind complement?






12. Which MHC presents intracellular peptides? how so?






13. What are the mediators that mast cells release?






14. What does interferon gamma do to be antiviral?






15. Leukocyte adhesion defect presents with...






16. what cell surface marker is used for NK cells as it is unique to them?






17. What are the autoantibodies for systemic sclerosis?






18. which antibody activate mast cells - basophils - and eosinophils?






19. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






20. hat is the presentation of Jobs syndrome or Hyper IgE?






21. How does complement link innate and adaptive?






22. What is three common causes of severe combined immunodef? What is the result of all three?






23. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






24. What lymph node drains the lateral side of the dorsum of the foot?






25. Which HLA's are included in MHC I? MHC II?

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26. Type Iv hypersensitivity is...






27. What does interferon gamma do? What two type of cells does it attack mostly?






28. T/F B cells do not require a second signal






29. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






30. What are the main symptoms of B cell immunodeficiencies?






31. What are the three types of APCs?






32. IgE has the ___________ in the serum






33. What is the general structure of an Ab?






34. what cytokine does basophils secrete?






35. What are the labs in brutons agammaglobulinemia?






36. What are the two signals required for Th1 cells? what happens after then activated?






37. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






38. What is passive immunity?






39. where do NK cells develop?






40. Which disease is associated with DR7?






41. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






42. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






43. For which toxins are preformed antibodies (passive) given?






44. what prevents NK cells from killing normal cells if their default is to kill?






45. What is the white pulp of the spleen?






46. Give an example of someone who could get hyperacute transplant rejection.






47. What are howell jolly bodies?






48. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






49. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






50. What is the presentation of hyperIgM syndrome?