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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is chronic mucocutaneous candidiasis d/t?






2. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






3. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






4. Complements are...






5. What are the two signals required for Th1 cells? what happens after then activated?






6. What is the defect in hyper IgM syndrome? What are the lab results?






7. The Fc region is found on the...






8. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






9. Which HLA's are included in MHC I? MHC II?

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10. What is a factor that is a predictor for a bad transplantation?






11. What is the main function of IL 8?






12. What lymph node drains the testes?






13. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






14. where do NK cells develop?






15. Describe the capsular structure of a lymph node; What are the functions of the LN?






16. can igG cross the placenta?






17. What are the main cell surface proteins on B cells?






18. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






19. In general What are T cells good for?






20. Which is the main antibody that provides passive immunity to infants?






21. other than mediating shock - what else does TNF alpha do? who releases it mainly?






22. What is the toxicity of azathioprine?






23. Which disease is associated with DR7?






24. What are the autoantibodies for pernicious anemia?






25. Which is the most abundant antibody in blood?






26. What is passive immunity?






27. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






28. What are some sinopulmonary infections?






29. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






30. what cell surface proteins are on all APCs?






31. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






32. which antibody activate mast cells - basophils - and eosinophils?






33. which of the hypersensitivity reactions is not Ab mediated?






34. What is oprelevkin? and What is it used for?






35. What is muromonab - CD3 (OKT3)






36. The idiotype; the Fc portion determines the...






37. which of the transplant rejections is antibody mediated? why does it occur?






38. What does interferon gamma do to be antiviral?






39. Leukocyte adhesion defect presents with...






40. What happens in a deficiency of C3?






41. What are the main symptoms of T cell immunodeficiencies?






42. What are the mediators that mast cells release?






43. What lymph node drains the duodenum - jejunum?






44. What lymph node drains the thigh?






45. describe the pathogenesis of delayed type IV hypersensitivity






46. What are the autoantibodies for myasthenia gravis?






47. give an example of how influenza does a major antigenic shift.






48. What are C1 - C2 - C3 - C4 important for?






49. What are the autoantibodies for sjorgens syndrome?






50. What is hereditary angioedema? What are the C3 levels?