Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Give an example of someone who could get hyperacute transplant rejection.






2. What kinds of receptors activate innate immunity?






3. What are howell jolly bodies?






4. What is the white pulp of the spleen?






5. when can graft versus host disease? What is the result?






6. What is Aldesleukin? What is it used for






7. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






8. What is an example of a parasite showing antigenic variation?






9. What is the mechanism for sirolimus? what else it known as?






10. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






11. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






12. What does IL 2 do?






13. Give three examples of bacteria that use antigenic variation and how.






14. What is chronic mucocutaneous candidiasis d/t?






15. Name 5 ways Antibody diversity is generated?






16. What are some catalase positive organisms?






17. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






18. What is the toxicity of azathioprine?






19. The secondary follicles have __________; primary follicles are dense






20. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






21. How fast does it occur?






22. What are superantigens? give two examples.






23. What is recomb gamma interferon used for?






24. The MALT/GALT are not...






25. What does granzyme do? who secretes it?






26. What does IgA pick up from epithelial cells before being secreted?






27. What are the autoantibodies for goodpastures syndrome?






28. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






29. From where do cytokines come from?






30. where are complements produced?






31. What does CD16 on NK cells do?






32. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






33. So antibodies are the effectors for the humoral response. List some of their functions.






34. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






35. What is the main cytokine that activates eosinophils?






36. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






37. where do NK cells develop?






38. What cytokines are released by Th1 cells?






39. What is the main function of TNF alpha? How does it do this?






40. What is the clinical use for sirolimus? what should you combine it with?






41. what prevents NK cells from killing normal cells if their default is to kill?






42. What cytokines to Th2 secrete?






43. What are the symptoms of serum sickness?






44. What does IL 4 do?






45. In general What are T cells good for?






46. Which disease is associated withB B27?






47. What is the presentation of scid? treatment?






48. What type of side chains are found on Fc region of an antibody?






49. What is a factor that is a predictor for a bad transplantation?






50. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?