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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Type IV hypersensitivity is i...






2. How is sirolimus different from tacrolimus?






3. which interleukin receptor is required for NK development? activation?






4. where are complements produced?






5. To what disease do the autoantibodies to IgG (rheumatoid factor)?






6. what will NK cells do to cells covered in IgG Ab? why?






7. What is the defect in hyper IgM syndrome? What are the lab results?






8. What are the three types of lymphocytes?






9. which of the transplant rejections is antibody mediated? why does it occur?






10. ________ regulate the cell mediated response.






11. What cytokines to Th2 secrete?






12. What are the autoantibodies for primary biliary cirrhosis?






13. where do somatic hypermutation and class switching occur?






14. What is the pathogenesis of a candida skin test?






15. What does interferon gamma do to be antiviral?






16. What lymph node drains the upper limb?






17. What is muromonab - CD3 (OKT3)






18. What are the two signals required for B cell class switching? Which is the second signal?






19. What are the two signals required for Th1 cells? what happens after then activated?






20. What is an example of a parasite showing antigenic variation?






21. what cell surface marker is used for NK cells as it is unique to them?






22. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






23. What is the presentation of Brutons agammaglobulinemia?






24. What does IL 4 do?






25. which of the hypersensitivity reactions is not Ab mediated?






26. What are the major functions of Antibodies?






27. describe the pathogenesis of delayed type IV hypersensitivity






28. What is recomb gamma interferon used for?






29. What are the autoantibodies for drug induced lupus?






30. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






31. What is the main function of IL 8?






32. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






33. What is the main cytokine that activates eosinophils?






34. What does CD16 on NK cells do?






35. Which HLA's are included in MHC I? MHC II?

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36. What are the two signals to kill for NK cells?






37. What are the autoantibodies for graves?






38. What are the three types of APCs?






39. What are the autoantibodies for type I diabetes mellitus?






40. What does it mean if there are igM in the serum at birth?






41. What do multimeric antibodies require for assembly?






42. Describe complement dependent Type II hypersensitivity. Give an example.






43. other than eat and bite RBCs what else do Macrophages of spleen do>






44. What is the autoantibody for SLE that is nonspecific? Specific?






45. What is recomb alpha interferon used for?






46. What is the cause of thymic aplasia? What is its presentation? What are the labs?






47. What does IL 10 do? who is secreted by?






48. What are target cells?






49. Name two endogenous pyrogens






50. What lymph node drains the thigh?







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