Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is hereditary angioedema? What are the C3 levels?






2. Monomer in circulation - ___ when secreted






3. what results in symptoms of shock in an acute hemolytic transfusion reaction?






4. What is recomb alpha interferon used for?






5. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






6. What are the autoantibodies for primary biliary cirrhosis?






7. Name two endogenous pyrogens






8. What does IgA pick up from epithelial cells before being secreted?






9. which interleukin receptor is required for NK development? activation?






10. What happens in a secondary follicle?






11. What are the three types of lymphocytes?






12. What are the three types of APCs?






13. Which antibodies can be multimeric?






14. What is the pathology of acute transplant rejection? is it reversible?






15. What are the two signals required for B cell class switching? Which is the second signal?






16. What are the main symptoms of T cell immunodeficiencies?






17. Describe the Mannose Lectin pathway






18. in which immunodef order do you see a lot of pus? no pus?






19. What are the function of B cells?






20. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






21. what happens in a deficiency of C1 esterase inhibitor? DAF?






22. what characterizes an arthus reaction?






23. What are the autoantibodies for polymyositis and dermatomyositis?






24. which antibody activate mast cells - basophils - and eosinophils?






25. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






26. What lymph node drains the lateral side of the dorsum of the foot?






27. What are the two signals required for Th1 cells? what happens after then activated?






28. What is the main function of TNF alpha? How does it do this?






29. What is recomb beta interferon used for?






30. What is the presentation of scid? treatment?






31. What are the major functions of Antibodies?






32. What are the labs in brutons agammaglobulinemia?






33. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






34. What are the autoantibodies for Celiac disease?






35. What is a type I hypersensitivity reaction? What is atopic?






36. The pathogenesis of contact dermatitis is ________ hypersensitivity






37. other than eat and bite RBCs what else do Macrophages of spleen do>






38. What is the main cytokine that activates eosinophils?






39. What is muromonab - CD3 (OKT3)






40. What portion of the lymph node is not well developed in DiGeorge Syndrome?






41. What kinds of receptors activate innate immunity?






42. In thymic development - What is the positive selection? negative selections?






43. What is the clinical use for sirolimus? what should you combine it with?






44. IgG...






45. Which diseases are associated with DR4?






46. Which diseases are associated with DR5?






47. How fast does it occur?






48. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






49. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






50. What does granulysin do?