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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the duodenum - jejunum?






2. What links the adaptive and innate immunity?






3. Only the _______ contribute to the Fc region






4. How is i Th1 helper cell inhibited?






5. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






6. What is the toxicity of muromonab?






7. What is the receptor for EBV? On what cells is that located?






8. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






9. What are MHC's necessary for? By themselves?






10. What is the clinical use for sirolimus? what should you combine it with?






11. What are the mediators that mast cells release?






12. what mediates the type II hypersensitivity? What are the two different methods?






13. What is three common causes of severe combined immunodef? What is the result of all three?






14. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






15. Leukocyte adhesion defect presents with...






16. what characterizes an arthus reaction?






17. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






18. Which MHC presents intracellular peptides? how so?






19. are Th cells involved in trapping of antigens of endotoxin/LPS?






20. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






21. What is the general structure of an Ab?






22. What is the pathogenesis of a candida skin test?






23. Which type of selection of thymic development provides central tolerance?






24. What is the pathology of acute transplant rejection? is it reversible?






25. What is the cause of thymic aplasia? What is its presentation? What are the labs?






26. __________ are a part of the innate system.






27. What does IgA pick up from epithelial cells before being secreted?






28. From where do cytokines come from?






29. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






30. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






31. The MALT/GALT are not...






32. where do somatic hypermutation and class switching occur?






33. where do NK cells develop?






34. Describe the capsular structure of a lymph node; What are the functions of the LN?






35. What are the autoantibodies for hashimotos?






36. What are the autoantibodies for pemphigus bulgaris?






37. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






38. What portion of the lymph node is not well developed in DiGeorge Syndrome?






39. What does IL 4 do?






40. What are the symptoms of serum sickness?






41. other than mediating shock - what else does TNF alpha do? who releases it mainly?






42. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






43. What are the autoantibodies for goodpastures syndrome?






44. What are the main symptoms of B cell immunodeficiencies?






45. What is the clinical use of Muromonab?






46. What are the autoantibodies for primary biliary cirrhosis?






47. What is passive immunity?






48. The Fc region is found on the...






49. What are the two signals to kill for NK cells?






50. What are the autoantibodies for systemic sclerosis?