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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what results in symptoms of shock in an acute hemolytic transfusion reaction?






2. What are the T cell functions?






3. which antibodies prevent antigens from binding mucosal surfaces?






4. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






5. What are the cell surface proteins for Macrophages? which two are for opsonins?






6. What is recomb beta interferon used for?






7. in which immunodef order do you see a lot of pus? no pus?






8. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






9. What cytokines are released by Th1 cells?






10. Complements are...






11. What is the pathogenesis of acute transplant rejection? When does it occur?






12. describe the pathogenesis of delayed type IV hypersensitivity






13. What is the clinical use for sirolimus? what should you combine it with?






14. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






15. Name 5 ways Antibody diversity is generated?






16. What does IgA pick up from epithelial cells before being secreted?






17. Which disease is associated with DR7?






18. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






19. which B and T cell disorder presents with specifically low IgM?






20. What is the main function of IL 8?






21. hat is the presentation of Jobs syndrome or Hyper IgE?






22. What are the autoantibodies for other vasculitides?






23. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






24. What is an example of a parasite showing antigenic variation?






25. What are howell jolly bodies?






26. Which disease is associated with DR3?






27. What is the pathogenesis of a candida skin test?






28. What is a factor that is a predictor for a bad transplantation?






29. What are superantigens? give two examples.






30. What is the presentation of Brutons agammaglobulinemia?






31. What is the main cytokine that activates eosinophils?






32. What is anergy? why does this occur?






33. Which diseases are associated with DR4?






34. What is the late phase reaction of anaphylaxis allergy? what mediates it?






35. What are the two signals required for B cell class switching? Which is the second signal?






36. What does CD16 on NK cells do?






37. What are the cell surface proteins on NK cells?






38. What are the function of B cells?






39. What is passive immunity?






40. What is the toxicity of azathioprine?






41. What are the main symptoms of B cell immunodeficiencies?






42. What are some sinopulmonary infections?






43. Which is the most abundant antibody in blood?






44. What are the autoantibodies for drug induced lupus?






45. What are MHC's necessary for? By themselves?






46. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






47. Which disease is associated withB B27?






48. What are the autoantibodies for pemphigus bulgaris?






49. What lymph node drains the rectum (above the pectinate line)?






50. To what portion of the Antibody do the complements bind?