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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?

2. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>

3. What is the clinical use for azathioprine?

4. what cell surface proteins are on all APCs?

5. What is the late phase reaction of anaphylaxis allergy? what mediates it?

6. which antibodies prevent antigens from binding mucosal surfaces?

7. What are some catalase positive organisms?

8. For which toxins are preformed antibodies (passive) given?

9. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?

10. What are the autoantibodies for drug induced lupus?

11. give an example of how influenza does a major antigenic shift.

12. Name 5 ways Antibody diversity is generated?

13. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?

14. What is the general structure of an Ab?

15. What is the common variable immunodeficiency ? How is it different from Brutons?

16. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?

17. what mediates the type II hypersensitivity? What are the two different methods?

18. What part of the lymph node specifically expands during a cellular immune response? when would this occur?

19. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?

20. What is the pathogenesis of a candida skin test?

21. Which antibody mediates immunity to worms? how?

22. Leukocyte adhesion defect presents with...

23. What is muromonab - CD3 (OKT3)

24. Monomer in circulation - ___ when secreted

25. what will NK cells do to cells covered in IgG Ab? why?

26. What is the clinical use of Muromonab?

27. Which diseases are associated with DR5?

28. What is the presentation of scid? treatment?

29. What are the PALS?

30. What is hereditary angioedema? What are the C3 levels?

31. What lymph node drains the scrotum?

32. Type Iv hypersensitivity is...

33. What is the cause of thymic aplasia? What is its presentation? What are the labs?

34. How does complement link innate and adaptive?

35. What is the most common selective Ig deficiency? What is the presentation?

36. What is filgrastim and sargramostim? and What is it used for?

37. What are the autoantibodies for graves?

38. What is recomb beta interferon used for?

39. What is the main function of IL 8?

40. So antibodies are the effectors for the humoral response. List some of their functions.

41. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?

42. What is recomb gamma interferon used for?

43. What are the autoantibodies for polymyositis and dermatomyositis?

44. What type of fenestrations are found in the red pulp of the spleen?

45. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?

46. What is an example of a parasite showing antigenic variation?

47. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?

48. What does CD16 on NK cells do?

49. What does IL 10 do? who is secreted by?

50. What are the function of B cells?