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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the presentation of scid? treatment?






2. other than mediating shock - what else does TNF alpha do? who releases it mainly?






3. What does interferon gamma do? What two type of cells does it attack mostly?






4. How is the antigen loaded onto a MHC II?






5. Which type of selection of thymic development provides central tolerance?






6. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






7. what prevents NK cells from killing normal cells if their default is to kill?






8. Which cytokines do Th2 release and For what?






9. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






10. What are the autoantibodies for drug induced lupus?






11. What is the late phase reaction of anaphylaxis allergy? what mediates it?






12. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






13. What are the function of B cells?






14. What can cause a lymph node enlargement?






15. What are the autoantibodies for pernicious anemia?






16. Which HLA's are included in MHC I? MHC II?

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17. Which are the only two antiinflammatory cytokines?






18. What lymph node drains the lateral side of the dorsum of the foot?






19. What lymph node drains the sigmoid colon?






20. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






21. Which disease is associated with HLA A3?






22. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






23. What is the toxicity of muromonab?






24. are Th cells involved in trapping of antigens of endotoxin/LPS?






25. IgE has the ___________ in the serum






26. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






27. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






28. What bugs can actually infect the lymph node itself?






29. Leukocyte adhesion defect presents with...






30. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






31. Which disease is associated with DR7?






32. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






33. What is three common causes of severe combined immunodef? What is the result of all three?






34. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






35. What is the general structure of an Ab?






36. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






37. What lymph node drains the duodenum - jejunum?






38. What links the adaptive and innate immunity?






39. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






40. What are the autoantibodies for other vasculitides?






41. What are the autoantibodies for sjorgens syndrome?






42. What does IgA pick up from epithelial cells before being secreted?






43. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






44. What is chronic mucocutaneous candidiasis d/t?






45. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






46. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






47. What is the pathogenesis of HyperIgE syndrome? What are the labs?






48. What does IL 2 do?






49. What lymph node drains the stomach?






50. How is sirolimus different from tacrolimus?