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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the two signals required for T cells? what happens after?






2. which cells have more complete tolerance - B or T cells?






3. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






4. How does the alternative pathway lead to MAC activation?






5. Give three examples of bacteria that use antigenic variation and how.






6. What is recomb beta interferon used for?






7. which antibodies can bind complement?






8. what results in symptoms of shock in an acute hemolytic transfusion reaction?






9. give an example of how influenza does a major antigenic shift.






10. What is the treatment of acute transplant rejection?






11. What are the autoantibodies for primary biliary cirrhosis?






12. What are MHC's necessary for? By themselves?






13. What does IL 5 do?






14. What is recomb alpha interferon used for?






15. What are the cell surface proteins on NK cells?






16. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






17. when can graft versus host disease? What is the result?






18. What are the autoantibodies for wegeners granulomatosis?






19. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






20. Which diseases are associated with DR4?






21. What is oprelevkin? and What is it used for?






22. What is three common causes of severe combined immunodef? What is the result of all three?






23. To what disease do the autoantibodies to IgG (rheumatoid factor)?






24. What are the three types of lymphocytes?






25. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






26. What cytokines are released by Th1 cells?






27. What does it mean if there are igM in the serum at birth?






28. What are the autoantibodies for myasthenia gravis?






29. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






30. Which diseases are associated with DR2?






31. What does granulysin do?






32. Which disease is associated with DR7?






33. __________ are a part of the innate system.






34. Which antibody mediates immunity to worms? how?






35. what cell surface proteins are on all APCs?






36. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






37. which of the transplant rejections is antibody mediated? why does it occur?






38. From where do cytokines come from?






39. What do mature naive B lymphocytes express?






40. What are the mediators that mast cells release?






41. What is digoxin immune Fab used for?






42. What is the toxicity of muromonab?






43. where are complements produced?






44. which of the hypersensitivity reactions is not Ab mediated?






45. What does interferon gamma do to be antiviral?






46. What are the cell surface proteins for Macrophages? which two are for opsonins?






47. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






48. What does IgA pick up from epithelial cells before being secreted?






49. What is the pathology in hyperacute transplant rejection?






50. what secretes IL 4?