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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what bacteria are a splenectomy patient most susceptible to? why?






2. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






3. What does it mean if there are igM in the serum at birth?






4. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






5. What are the main Cell surface proteins on T cells?






6. The MALT/GALT are not...






7. What is the main function of IL 12? other than macrophages who else can release IL 12?






8. What is the toxicity of muromonab?






9. Which are the only two antiinflammatory cytokines?






10. Which is the most abundant antibody in blood?






11. What are the labs in brutons agammaglobulinemia?






12. What do mature naive B lymphocytes express?






13. what will NK cells do to cells covered in IgG Ab? why?






14. which of the transplant rejections is antibody mediated? why does it occur?






15. which cells have more complete tolerance - B or T cells?






16. Which disease is associated with DR7?






17. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






18. What are howell jolly bodies?






19. Other than stimulating fever - what else does IL 6 do?






20. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






21. The secondary follicles have __________; primary follicles are dense






22. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






23. What are the autoantibodies for primary biliary cirrhosis?






24. What is passive immunity?






25. What bugs can actually infect the lymph node itself?






26. What is colostrum?






27. What is the clinical use for azathioprine?






28. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






29. What are C1 - C2 - C3 - C4 important for?






30. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






31. What are the autoantibodies for systemic sclerosis?






32. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






33. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






34. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






35. Complements are...






36. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






37. what mediates the type II hypersensitivity? What are the two different methods?






38. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






39. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






40. What are the two signals required for T cells? what happens after?






41. Which type of selection of thymic development provides central tolerance?






42. Which diseases are associated with DR5?






43. What are the autoantibodies for pernicious anemia?






44. What is the main function of interferons?






45. What is the main function of IL 8?






46. What does interferon gamma do? What two type of cells does it attack mostly?






47. What is muromonab - CD3 (OKT3)






48. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






49. Which antibodies can be multimeric?






50. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?