Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






2. The Fc region is found on the...






3. How is i Th1 helper cell inhibited?






4. To what disease do the autoantibodies to IgG (rheumatoid factor)?






5. which cytokine inhibits TH2 cells? secreted by who?






6. what results in symptoms of shock in an acute hemolytic transfusion reaction?






7. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






8. What does it mean if there are igM in the serum at birth?






9. To what portion of the Antibody do the complements bind?






10. What is filgrastim and sargramostim? and What is it used for?






11. What is the white pulp of the spleen?






12. Which antibody mediates immunity to worms? how?






13. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






14. Name 5 ways Antibody diversity is generated?






15. What is an example of a parasite showing antigenic variation?






16. What are the autoantibodies for autoimmune hepatitis?






17. What is the pathogenesis of acute transplant rejection? When does it occur?






18. Give an example of someone who could get hyperacute transplant rejection.






19. are Th cells involved in trapping of antigens of endotoxin/LPS?






20. what characterizes an arthus reaction?






21. What are the main cell surface proteins on B cells?






22. Which type of selection of thymic development provides central tolerance?






23. which antibody activate mast cells - basophils - and eosinophils?






24. which interleukin receptor is required for NK development? activation?






25. What is the main cytokine released by T cells? What does it do






26. What is the pathogenesis of a hypersensitivity reaction?






27. What are the cell surface proteins for Macrophages? which two are for opsonins?






28. Which disease is associated with DR7?






29. which cells have more complete tolerance - B or T cells?






30. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






31. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






32. IgM can fix complement but...






33. What cytokines are released by Th1 cells?






34. What are the autoantibodies for systemic sclerosis?






35. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






36. What is the clinical use of Muromonab?






37. What are howell jolly bodies?






38. __________ are a part of the innate system.






39. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






40. where are complements produced?






41. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






42. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






43. What does IL 5 do?






44. What is the common variable immunodeficiency ? How is it different from Brutons?






45. The ______ in the BM are DN - the DP are in the cortex of thymus






46. Which disease is associated with HLA A3?






47. What is recomb alpha interferon used for?






48. What is the presentation of hyperIgM syndrome?






49. What lymph node drains the thigh?






50. Describe the capsular structure of a lymph node; What are the functions of the LN?