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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which helper T cells' development is induced by IL 4? IL 12?






2. What lymph node drains the scrotum?






3. Which diseases are associated with DR4?






4. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






5. What is oprelevkin? and What is it used for?






6. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






7. What is the clinical use of Muromonab?






8. describe the pathogenesis of delayed type IV hypersensitivity






9. What are the two signals required for B cell class switching? Which is the second signal?






10. What are the three types of APCs?






11. Describe the complement independent Type II hypersenstivity reaction. Give an example.






12. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






13. What is the white pulp of the spleen?






14. What are the two signals required for T cells? what happens after?






15. what characterizes an arthus reaction?






16. What lymph node drains the lateral side of the dorsum of the foot?






17. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






18. Describe the capsular structure of a lymph node; What are the functions of the LN?






19. What is the main function of TNF alpha? How does it do this?






20. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






21. What are some catalase positive organisms?






22. What is the receptor for EBV? On what cells is that located?






23. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






24. which cells have more complete tolerance - B or T cells?






25. What are the two signals required for Th1 cells? what happens after then activated?






26. which B and T cell disorder presents with specifically low IgM?






27. What is recomb alpha interferon used for?






28. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






29. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






30. What cytokines are released by Th1 cells?






31. What lymph node drains the breast?






32. Which is the main antibody in the delayed or secondary response to an antigen?






33. What is the pathogenesis of HyperIgE syndrome? What are the labs?






34. How fast does it occur?






35. What can cause a lymph node enlargement?






36. which cytokine inhibits TH2 cells? secreted by who?






37. What are the autoantibodies for pernicious anemia?






38. What is the pathology seen in chronic transplant rejection?






39. The secondary follicles have __________; primary follicles are dense






40. What are the three types of lymphocytes?






41. The two heavy chains of an antibody contribute to the...






42. are Th cells involved in trapping of antigens of endotoxin/LPS?






43. ________ regulate the cell mediated response.






44. What is the pathogenesis of a candida skin test?






45. what mediates the type II hypersensitivity? What are the two different methods?






46. Which cytokines do Th2 release and For what?






47. What are the autoantibodies for wegeners granulomatosis?






48. What are the main symptoms of B cell immunodeficiencies?






49. What lymph node drains the thigh?






50. is IgM an opsonizer?







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