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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the three types of APCs?






2. What are four results of a splenectomy?






3. How is the thymus organized? what happens in each section?






4. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






5. What is the pathology seen in chronic transplant rejection?






6. Which cytokines do Th2 release and For what?






7. What is the most common example of passive immunity?






8. What lymph node drains the testes?






9. Name the three opsonins






10. What are C1 - C2 - C3 - C4 important for?






11. What is the main function of IL 8?






12. To what disease do the autoantibodies to IgG (rheumatoid factor)?






13. What are the three types of lymphocytes?






14. What happens in a deficiency of C3?






15. what ensure that a memory response is generated?






16. What is three common causes of severe combined immunodef? What is the result of all three?






17. What are some catalase positive organisms?






18. can igG cross the placenta?






19. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






20. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






21. What is the presentation of Brutons agammaglobulinemia?






22. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






23. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






24. What is the receptor for EBV? On what cells is that located?






25. What is the autoantibody for SLE that is nonspecific? Specific?






26. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






27. What are the two signals required for T cells? what happens after?






28. What are the two signals to kill for NK cells?






29. which cells have more complete tolerance - B or T cells?






30. In general What are T cells good for?






31. other than C3a - what other complement acts as an anaphyloxin?






32. What are the major functions of Antibodies?






33. What are the autoantibodies for type I diabetes mellitus?






34. What is digoxin immune Fab used for?






35. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






36. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






37. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






38. are Th cells involved in trapping of antigens of endotoxin/LPS?






39. What does CD16 on NK cells do?






40. Name two endogenous pyrogens






41. What does IL 4 do?






42. What is the common variable immunodeficiency ? How is it different from Brutons?






43. which antibodies can bind complement?






44. which antibody is involved in the primary response or immediate response to an antigen?






45. What is serum sickness? give an example.






46. What does IL 10 do? who is secreted by?






47. What do mature naive B lymphocytes express?






48. How is the antigen loaded onto a MHC II?






49. give an example of how influenza does a major antigenic shift.






50. What is the defect in hyper IgM syndrome? What are the lab results?