Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. IgE has the ___________ in the serum






2. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






3. Type IV hypersensitivity is i...






4. what characterizes an arthus reaction?






5. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






6. So antibodies are the effectors for the humoral response. List some of their functions.






7. what secretes IL 4?






8. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






9. What can cause a lymph node enlargement?






10. What happens in a deficiency of C3?






11. Other than stimulating fever - what else does IL 6 do?






12. The secondary follicles have __________; primary follicles are dense






13. What is the common variable immunodeficiency ? How is it different from Brutons?






14. What portion of the lymph node is not well developed in DiGeorge Syndrome?






15. what cytokine does basophils secrete?






16. What are C1 - C2 - C3 - C4 important for?






17. which B and T cell disorder presents with specifically low IgM?






18. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






19. What is recomb gamma interferon used for?






20. What are the autoantibodies for graves?






21. What is serum sickness? give an example.






22. What cytokines to Th2 secrete?






23. What are the autoantibodies for wegeners granulomatosis?






24. The ______ in the BM are DN - the DP are in the cortex of thymus






25. What is the treatment of acute transplant rejection?






26. What lymph node drains the duodenum - jejunum?






27. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






28. What is the pathogenesis of a hypersensitivity reaction?






29. What does CD16 on NK cells do?






30. What are the main cell surface proteins on B cells?






31. What is digoxin immune Fab used for?






32. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






33. __________ are a part of the innate system.






34. The two heavy chains of an antibody contribute to the...






35. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






36. What are the cell surface proteins for Macrophages? which two are for opsonins?






37. What does granzyme do? who secretes it?






38. How do you test for type III hypersensitivity?






39. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






40. What are the autoantibodies for type I diabetes mellitus?






41. What lymph node drains the stomach?






42. For which toxins are preformed antibodies (passive) given?






43. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






44. where do NK cells develop?






45. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






46. Which MHC presents intracellular peptides? how so?






47. IgM can exist as a _______ also






48. To what disease do the autoantibodies to IgG (rheumatoid factor)?






49. Name 5 ways Antibody diversity is generated?






50. what cell surface marker is used for NK cells as it is unique to them?