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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






2. What is the main function of IL 12? other than macrophages who else can release IL 12?






3. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






4. What is immune complex disease? give an example.






5. where do NK cells develop?






6. which cytokine inhibits TH2 cells? secreted by who?






7. Which is the main antibody in the delayed or secondary response to an antigen?






8. which antibody is involved in the primary response or immediate response to an antigen?






9. What cytokines to Th2 secrete?






10. What is the presentation of Brutons agammaglobulinemia?






11. What are the autoantibodies for graves?






12. What are the two signals required for B cell class switching? Which is the second signal?






13. In thymic development - What is the positive selection? negative selections?






14. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






15. What are the two signals required for T cells? what happens after?






16. The two heavy chains of an antibody contribute to the...






17. which B and T cell disorder presents with specifically low IgM?






18. What are the three types of lymphocytes?






19. What are the autoantibodies for goodpastures syndrome?






20. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






21. which antibodies prevent antigens from binding mucosal surfaces?






22. What is the clinical use for azathioprine?






23. what prevents NK cells from killing normal cells if their default is to kill?






24. What are the PALS?






25. In general What are T cells good for?






26. What does IL 4 do?






27. what happens in a deficiency of C1 esterase inhibitor? DAF?






28. Which helper T cells' development is induced by IL 4? IL 12?






29. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






30. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






31. The MALT/GALT are not...






32. What cytokines are released by Th1 cells?






33. is IgM an opsonizer?






34. What are the mediators that mast cells release?






35. what secretes IL 4?






36. A lymph node is a ________ lymphoid organ.






37. What is the main function of interferons?






38. What does it mean if there are igM in the serum at birth?






39. What are the main Cell surface proteins on T cells?






40. Which antibodies can be multimeric?






41. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






42. What is the common variable immunodeficiency ? How is it different from Brutons?






43. Which disease is associated with DR7?






44. What type of side chains are found on Fc region of an antibody?






45. What is oprelevkin? and What is it used for?






46. which of the hypersensitivity reactions is not Ab mediated?






47. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






48. What does Interferon alpha and beta do? how?






49. What is recomb alpha interferon used for?






50. How does igA cross the epithelium?







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