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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. give an example of how influenza does a major antigenic shift.






2. What are the autoantibodies for polymyositis and dermatomyositis?






3. which cytokine inhibits TH2 cells? secreted by who?






4. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






5. What does interferon gamma do? What two type of cells does it attack mostly?






6. which B and T cell disorder presents with specifically low IgM?






7. What is the toxicity of azathioprine?






8. What does it mean if there are igM in the serum at birth?






9. What lymph node drains the anal canal (below the pectinate line)?






10. What is the main function of IL 8?






11. What is the presentation of hyperIgM syndrome?






12. describe the pathogenesis of delayed type IV hypersensitivity






13. is IgM an opsonizer?






14. What are the cell surface proteins for Macrophages? which two are for opsonins?






15. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






16. what cytokine does basophils secrete?






17. what prevents NK cells from killing normal cells if their default is to kill?






18. What is a factor that is a predictor for a bad transplantation?






19. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






20. What is the common variable immunodeficiency ? How is it different from Brutons?






21. What is the marginal zone of the spleen? what happens there?






22. The two heavy chains of an antibody contribute to the...






23. IgE has the ___________ in the serum






24. What is the clinical use of Muromonab?






25. What are the autoantibodies for type I diabetes mellitus?






26. What are the three types of lymphocytes?






27. What are the main symptoms of B cell immunodeficiencies?






28. What is an example of a parasite showing antigenic variation?






29. The MALT/GALT are not...






30. which antibodies prevent antigens from binding mucosal surfaces?






31. what secretes IL 4?






32. Which HLA's are included in MHC I? MHC II?

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33. Type Iv hypersensitivity is...






34. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






35. What is digoxin immune Fab used for?






36. What are target cells?






37. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






38. What is epo used for?






39. What is the mechanism for sirolimus? what else it known as?






40. What kinds of receptors activate innate immunity?






41. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






42. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






43. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






44. So antibodies are the effectors for the humoral response. List some of their functions.






45. What is the late phase reaction of anaphylaxis allergy? what mediates it?






46. What is the cause of thymic aplasia? What is its presentation? What are the labs?






47. other than mediating shock - what else does TNF alpha do? who releases it mainly?






48. What lymph node drains the breast?






49. Name 5 ways Antibody diversity is generated?






50. How is sirolimus different from tacrolimus?