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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the rectum (above the pectinate line)?






2. What is the pathology of acute transplant rejection? is it reversible?






3. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






4. What are the main Cell surface proteins on T cells?






5. A lymph node is a ________ lymphoid organ.






6. Which disease is associated withB B27?






7. How is sirolimus different from tacrolimus?






8. How fast does it occur?






9. Which diseases are associated with DR2?






10. What is a type I hypersensitivity reaction? What is atopic?






11. Name two endogenous pyrogens






12. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






13. What does interferon gamma do to be antiviral?






14. What are the autoantibodies for Celiac disease?






15. What bugs can actually infect the lymph node itself?






16. What are the main symptoms of T cell immunodeficiencies?






17. What is oprelevkin? and What is it used for?






18. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






19. What are the autoantibodies for graves?






20. What lymph node drains the stomach?






21. IgE has the ___________ in the serum






22. Which is the most abundant antibody in blood?






23. what bacteria are a splenectomy patient most susceptible to? why?






24. Which HLA's are included in MHC I? MHC II?

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25. What is the presentation of hyperIgM syndrome?






26. What are the mediators that mast cells release?






27. What does CD16 on NK cells do?






28. What is colostrum?






29. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






30. What does granzyme do? who secretes it?






31. What does IL 2 do?






32. What is the toxicity of muromonab?






33. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






34. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






35. What is a factor that is a predictor for a bad transplantation?






36. How does igA cross the epithelium?






37. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






38. What is the pathogenesis of a hypersensitivity reaction?






39. What are the major functions of Antibodies?






40. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






41. What lymph node drains the sigmoid colon?






42. What is the general structure of an Ab?






43. What does IgA pick up from epithelial cells before being secreted?






44. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






45. Describe the Mannose Lectin pathway






46. What is the treatment of acute transplant rejection?






47. What are superantigens? give two examples.






48. can igG cross the placenta?






49. which of the hypersensitivity reactions is not Ab mediated?






50. What does IL 5 do?







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