Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






2. What are the autoantibodies for myasthenia gravis?






3. Name two endogenous pyrogens






4. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






5. Describe the Mannose Lectin pathway






6. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






7. What are the autoantibodies for Celiac disease?






8. What are MHC's necessary for? By themselves?






9. What are the main Cell surface proteins on T cells?






10. IgG...






11. Complements are...






12. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






13. IgM can fix complement but...






14. Which HLA's are included in MHC I? MHC II?

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183


15. What is epo used for?






16. What lymph node drains the breast?






17. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






18. What are the two signals required for T cells? what happens after?






19. which of the transplant rejections is antibody mediated? why does it occur?






20. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






21. What is the autoantibody for SLE that is nonspecific? Specific?






22. What bugs can actually infect the lymph node itself?






23. So antibodies are the effectors for the humoral response. List some of their functions.






24. Give three examples of bacteria that use antigenic variation and how.






25. What lymph node drains the scrotum?






26. What are superantigens? give two examples.






27. What does CD16 on NK cells do?






28. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






29. What are howell jolly bodies?






30. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






31. Only the _______ contribute to the Fc region






32. What is an example of a parasite showing antigenic variation?






33. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






34. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






35. Which diseases are associated with DR5?






36. IgE has the ___________ in the serum






37. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






38. what mediates the type II hypersensitivity? What are the two different methods?






39. what ensure that a memory response is generated?






40. Which disease is associated with DR7?






41. which of the hypersensitivity reactions is not Ab mediated?






42. which cells have more complete tolerance - B or T cells?






43. To what disease do the autoantibodies to IgG (rheumatoid factor)?






44. Which diseases are associated with DR4?






45. What is the pathogenesis of HyperIgE syndrome? What are the labs?






46. How is the antigen loaded onto a MHC II?






47. What are the autoantibodies for graves?






48. where are complements produced?






49. What is the clinical use for sirolimus? what should you combine it with?






50. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?