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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what secretes IL 4?






2. The pathogenesis of contact dermatitis is ________ hypersensitivity






3. What is the white pulp of the spleen?






4. What is the pathogenesis of HyperIgE syndrome? What are the labs?






5. Which is the most abundant antibody in blood?






6. which of the hypersensitivity reactions is not Ab mediated?






7. What lymph node drains the upper limb?






8. What cytokines to Th2 secrete?






9. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






10. Which disease is associated with B8?






11. What lymph node drains the thigh?






12. what will NK cells do to cells covered in IgG Ab? why?






13. what results in symptoms of shock in an acute hemolytic transfusion reaction?






14. are Th cells involved in trapping of antigens of endotoxin/LPS?






15. What is passive immunity?






16. IgG...






17. which B and T cell disorder presents with specifically low IgM?






18. Which is the main antibody that provides passive immunity to infants?






19. What is filgrastim and sargramostim? and What is it used for?






20. The secondary follicles have __________; primary follicles are dense






21. What are the T cell functions?






22. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






23. other than mediating shock - what else does TNF alpha do? who releases it mainly?






24. Name two endogenous pyrogens






25. What is the main cytokine that activates eosinophils?






26. In general What are T cells good for?






27. Monomer in circulation - ___ when secreted






28. which antibodies prevent antigens from binding mucosal surfaces?






29. What are MHC's necessary for? By themselves?






30. What is colostrum?






31. What is an example of a parasite showing antigenic variation?






32. Which diseases are associated with DR2?






33. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






34. What is recomb alpha interferon used for?






35. What is the main function of IL 8?






36. The Fc region is found on the...






37. What is immune complex disease? give an example.






38. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






39. What are the autoantibodies for type I diabetes mellitus?






40. What is the toxicity of muromonab?






41. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






42. What is the clinical use of Muromonab?






43. Give an example of someone who could get hyperacute transplant rejection.






44. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






45. ________ regulate the cell mediated response.






46. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






47. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






48. give an example of how influenza does a major antigenic shift.






49. How is the antigen loaded onto a MHC II?






50. What is digoxin immune Fab used for?







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