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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What type of fenestrations are found in the red pulp of the spleen?






2. What are the autoantibodies for goodpastures syndrome?






3. What are four results of a splenectomy?






4. The alternative pathway is the only constutively...






5. What is a factor that is a predictor for a bad transplantation?






6. What is the defect in hyper IgM syndrome? What are the lab results?






7. what will NK cells do to cells covered in IgG Ab? why?






8. What are superantigens? give two examples.






9. IgM can fix complement but...






10. What does IL 4 do?






11. Which antibody mediates immunity to worms? how?






12. What lymph node drains the testes?






13. What are the two signals required for B cell class switching? Which is the second signal?






14. which B and T cell disorder presents with specifically low IgM?






15. What cytokines to Th2 secrete?






16. describe the pathogenesis of delayed type IV hypersensitivity






17. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






18. What is Aldesleukin? What is it used for






19. What is filgrastim and sargramostim? and What is it used for?






20. What does interferon gamma do to be antiviral?






21. Complements are...






22. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






23. What lymph node drains the duodenum - jejunum?






24. What do multimeric antibodies require for assembly?






25. What are the autoantibodies for type I diabetes mellitus?






26. what prevents NK cells from killing normal cells if their default is to kill?






27. What are the PALS?






28. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






29. How is the thymus organized? what happens in each section?






30. hat is the presentation of Jobs syndrome or Hyper IgE?






31. Which disease is associated with DR3?






32. which antibodies can bind complement?






33. What do mature naive B lymphocytes express?






34. describe the classic complement pathway.






35. What lymph node drains the sigmoid colon?






36. The idiotype; the Fc portion determines the...






37. What can cause a lymph node enlargement?






38. when can graft versus host disease? What is the result?






39. What is the main function of TNF alpha? How does it do this?






40. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






41. To what portion of the Antibody do the complements bind?






42. What is colostrum?






43. IgG...






44. What are the autoantibodies for Celiac disease?






45. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






46. What are the autoantibodies for drug induced lupus?






47. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






48. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






49. What is the clinical use for azathioprine?






50. where are complements produced?