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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. From where do cytokines come from?






2. What are target cells?






3. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






4. Which is the main antibody that provides passive immunity to infants?






5. What is hereditary angioedema? What are the C3 levels?






6. other than mediating shock - what else does TNF alpha do? who releases it mainly?






7. What is the pathogenesis of a candida skin test?






8. What are the two signals to kill for NK cells?






9. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






10. what mediates the type II hypersensitivity? What are the two different methods?






11. What is passive immunity?






12. What is digoxin immune Fab used for?






13. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






14. What are the three types of APCs?






15. what results in symptoms of shock in an acute hemolytic transfusion reaction?






16. can igG cross the placenta?






17. What is thrombopoietin used for?






18. What are four results of a splenectomy?






19. The secondary follicles have __________; primary follicles are dense






20. what characterizes an arthus reaction?






21. Type Iv hypersensitivity is...






22. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






23. what prevents NK cells from killing normal cells if their default is to kill?






24. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






25. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






26. What is recomb beta interferon used for?






27. Which is the most abundant antibody in blood?






28. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






29. What cytokines are released by Th1 cells?






30. What does it mean if there are igM in the serum at birth?






31. The MALT/GALT are not...






32. what cell surface marker is used for NK cells as it is unique to them?






33. where are complements produced?






34. What is the presentation of hyperIgM syndrome?






35. How is sirolimus different from tacrolimus?






36. What is the presentation of scid? treatment?






37. What lymph node drains the testes?






38. What type of side chains are found on Fc region of an antibody?






39. What are the two signals required for T cells? what happens after?






40. What lymph node drains the rectum (above the pectinate line)?






41. What does granulysin do?






42. What is the pathogenesis of a hypersensitivity reaction?






43. What are the autoantibodies for wegeners granulomatosis?






44. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






45. which antibodies prevent antigens from binding mucosal surfaces?






46. What is three common causes of severe combined immunodef? What is the result of all three?






47. What are the main symptoms of T cell immunodeficiencies?






48. What lymph node drains the duodenum - jejunum?






49. What are the main cell surface proteins on B cells?






50. The pathogenesis of contact dermatitis is ________ hypersensitivity