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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which is the main antibody that provides passive immunity to infants?






2. What are the main Cell surface proteins on T cells?






3. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






4. What lymph node drains the duodenum - jejunum?






5. Which disease is associated with B8?






6. What type of fenestrations are found in the red pulp of the spleen?






7. To what disease do the autoantibodies to IgG (rheumatoid factor)?






8. What do mature naive B lymphocytes express?






9. What is immune complex disease? give an example.






10. Which disease is associated withB B27?






11. What is the presentation of common variable immunodef? and What are the labs?






12. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






13. How is the thymus organized? what happens in each section?






14. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






15. in which immunodef order do you see a lot of pus? no pus?






16. What is the main cytokine released by T cells? What does it do






17. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






18. What links the adaptive and innate immunity?






19. What lymph node drains the testes?






20. What is a type I hypersensitivity reaction? What is atopic?






21. Which is the main antibody in the delayed or secondary response to an antigen?






22. What are superantigens? give two examples.






23. The secondary follicles have __________; primary follicles are dense






24. What are the three types of lymphocytes?






25. What are the cell surface proteins on NK cells?






26. Which HLA's are included in MHC I? MHC II?

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27. What is the cause of thymic aplasia? What is its presentation? What are the labs?






28. what results in symptoms of shock in an acute hemolytic transfusion reaction?






29. What does IL 4 do?






30. Which cytokines do Th2 release and For what?






31. describe the pathogenesis of delayed type IV hypersensitivity






32. where do somatic hypermutation and class switching occur?






33. What are the autoantibodies for graves?






34. What does interferon gamma do? What two type of cells does it attack mostly?






35. other than eat and bite RBCs what else do Macrophages of spleen do>






36. What is epo used for?






37. Describe complement dependent Type II hypersensitivity. Give an example.






38. What are the autoantibodies for myasthenia gravis?






39. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






40. The ______ in the BM are DN - the DP are in the cortex of thymus






41. Describe the Mannose Lectin pathway






42. What are C1 - C2 - C3 - C4 important for?






43. What is the presentation of hyperIgM syndrome?






44. What are the major functions of Antibodies?






45. what prevents NK cells from killing normal cells if their default is to kill?






46. What type of side chains are found on Fc region of an antibody?






47. where are complements produced?






48. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






49. What lymph node drains the breast?






50. What lymph node drains the upper limb?