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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. So antibodies are the effectors for the humoral response. List some of their functions.






2. what secretes IL 4?






3. How is i Th1 helper cell inhibited?






4. What are the labs in brutons agammaglobulinemia?






5. The alternative pathway is the only constutively...






6. IgM can exist as a _______ also






7. How is the antigen loaded onto a MHC II?






8. What is the main function of TNF alpha? How does it do this?






9. What are the cell surface proteins for Macrophages? which two are for opsonins?






10. What is an example of a parasite showing antigenic variation?






11. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






12. How do you test for type III hypersensitivity?






13. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






14. Which is the most abundant antibody in blood?






15. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






16. What are the autoantibodies for wegeners granulomatosis?






17. What are the autoantibodies for drug induced lupus?






18. What are the autoantibodies for hashimotos?






19. What is three common causes of severe combined immunodef? What is the result of all three?






20. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






21. What is hereditary angioedema? What are the C3 levels?






22. which cytokine inhibits TH2 cells? secreted by who?






23. What are the main symptoms of T cell immunodeficiencies?






24. what characterizes an arthus reaction?






25. What does interferon gamma do to be antiviral?






26. What is anergy? why does this occur?






27. How does complement link innate and adaptive?






28. What is the late phase reaction of anaphylaxis allergy? what mediates it?






29. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






30. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






31. What is the presentation of scid? treatment?






32. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






33. __________ are a part of the innate system.






34. Which antibodies can be multimeric?






35. In thymic development - What is the positive selection? negative selections?






36. The Fc region is found on the...






37. What lymph node drains the stomach?






38. What are the autoantibodies for autoimmune hepatitis?






39. What lymph node drains the breast?






40. which antibody activate mast cells - basophils - and eosinophils?






41. which cells have more complete tolerance - B or T cells?






42. What are some sinopulmonary infections?






43. Only the _______ contribute to the Fc region






44. What is digoxin immune Fab used for?






45. What is the pathology in hyperacute transplant rejection?






46. What is the pathology seen in chronic transplant rejection?






47. Which is the main antibody in the delayed or secondary response to an antigen?






48. What is the main function of interferons?






49. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






50. What are the four steps in phagocytosis? What are the four disease that correspond to each step?