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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. ________ regulate the cell mediated response.






2. hat is the presentation of Jobs syndrome or Hyper IgE?






3. What is the general structure of an Ab?






4. What are the three types of APCs?






5. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






6. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






7. What is the toxicity of muromonab?






8. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






9. What is an example of a parasite showing antigenic variation?






10. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






11. What are the cell surface proteins on NK cells?






12. what secretes IL 4?






13. What are the function of B cells?






14. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






15. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






16. What is the toxicity of azathioprine?






17. What lymph node drains the lateral side of the dorsum of the foot?






18. What is the main function of TNF alpha? How does it do this?






19. which cells have more complete tolerance - B or T cells?






20. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






21. other than mediating shock - what else does TNF alpha do? who releases it mainly?






22. What is the main function of IL 12? other than macrophages who else can release IL 12?






23. What is chronic mucocutaneous candidiasis d/t?






24. The secondary follicles have __________; primary follicles are dense






25. What are the main Cell surface proteins on T cells?






26. What is serum sickness? give an example.






27. what happens in a deficiency of C1 esterase inhibitor? DAF?






28. What does interferon gamma do? What two type of cells does it attack mostly?






29. What is the pathogenesis of acute transplant rejection? When does it occur?






30. From where do cytokines come from?






31. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






32. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






33. What are the autoantibodies for wegeners granulomatosis?






34. What lymph node drains the sigmoid colon?






35. What does IL 2 do?






36. What cytokines to Th2 secrete?






37. Which disease is associated with B8?






38. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






39. What do multimeric antibodies require for assembly?






40. what ensure that a memory response is generated?






41. What happens in a deficiency of C3?






42. what mediates the type II hypersensitivity? What are the two different methods?






43. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






44. What happens in a secondary follicle?






45. IgM can fix complement but...






46. What are the autoantibodies for graves?






47. Only the _______ contribute to the Fc region






48. The alternative pathway is the only constutively...






49. What is oprelevkin? and What is it used for?






50. What are the autoantibodies for other vasculitides?