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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






2. which B and T cell disorder presents with specifically low IgM?






3. What are the autoantibodies for wegeners granulomatosis?






4. What is the clinical use for sirolimus? what should you combine it with?






5. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






6. What is chronic mucocutaneous candidiasis d/t?






7. What is the treatment of acute transplant rejection?






8. In thymic development - What is the positive selection? negative selections?






9. other than mediating shock - what else does TNF alpha do? who releases it mainly?






10. Which helper T cells' development is induced by IL 4? IL 12?






11. What are the two signals required for T cells? what happens after?






12. What are the autoantibodies for sjorgens syndrome?






13. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






14. What do mature naive B lymphocytes express?






15. which of the transplant rejections is antibody mediated? why does it occur?






16. How fast does it occur?






17. Only the _______ contribute to the Fc region






18. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






19. Which disease is associated with DR3?






20. are Th cells involved in trapping of antigens of endotoxin/LPS?






21. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






22. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






23. How do you test for type III hypersensitivity?






24. The alternative pathway is the only constutively...






25. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






26. Which diseases are associated with DR5?






27. what cell surface proteins are on all APCs?






28. What is the receptor for EBV? On what cells is that located?






29. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






30. What are C1 - C2 - C3 - C4 important for?






31. what ensure that a memory response is generated?






32. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






33. what secretes IL 4?






34. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






35. What is the pathology seen in chronic transplant rejection?






36. How does complement link innate and adaptive?






37. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






38. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






39. What are the mediators that mast cells release?






40. What is the most common selective Ig deficiency? What is the presentation?






41. IgM can exist as a _______ also






42. How does igA cross the epithelium?






43. From where do cytokines come from?






44. The lymphocytes are ________ origin






45. what mediates the type II hypersensitivity? What are the two different methods?






46. The two heavy chains of an antibody contribute to the...






47. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






48. What are the autoantibodies for pemphigus bulgaris?






49. What lymph node drains the anal canal (below the pectinate line)?






50. What are howell jolly bodies?