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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which antibody mediates immunity to worms? how?






2. What is digoxin immune Fab used for?






3. What lymph node drains the scrotum?






4. where do NK cells develop?






5. What is the main function of IL 12? other than macrophages who else can release IL 12?






6. What do mature naive B lymphocytes express?






7. Which helper T cells' development is induced by IL 4? IL 12?






8. What are the main symptoms of T cell immunodeficiencies?






9. What are the autoantibodies for wegeners granulomatosis?






10. How is the antigen loaded onto a MHC II?






11. Which HLA's are included in MHC I? MHC II?

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12. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






13. What lymph node drains the lateral side of the dorsum of the foot?






14. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






15. What are the autoantibodies for Celiac disease?






16. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






17. What is three common causes of severe combined immunodef? What is the result of all three?






18. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






19. What does interferon gamma do? What two type of cells does it attack mostly?






20. What are the main cell surface proteins on B cells?






21. What are the T cell functions?






22. What are the autoantibodies for systemic sclerosis?






23. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






24. What is the treatment of acute transplant rejection?






25. What happens in a secondary follicle?






26. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






27. What is the pathogenesis of acute transplant rejection? When does it occur?






28. What are the autoantibodies for goodpastures syndrome?






29. Only the _______ contribute to the Fc region






30. which of the transplant rejections is antibody mediated? why does it occur?






31. What is recomb beta interferon used for?






32. The Fc region is found on the...






33. What lymph node drains the breast?






34. What is the white pulp of the spleen?






35. What is muromonab - CD3 (OKT3)






36. what characterizes an arthus reaction?






37. Describe complement dependent Type II hypersensitivity. Give an example.






38. What is the main cytokine that activates eosinophils?






39. What is chronic mucocutaneous candidiasis d/t?






40. What is the clinical use of Muromonab?






41. What are the autoantibodies for hashimotos?






42. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






43. What is filgrastim and sargramostim? and What is it used for?






44. The ______ in the BM are DN - the DP are in the cortex of thymus






45. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






46. What is the main cytokine released by T cells? What does it do






47. What portion of the lymph node is not well developed in DiGeorge Syndrome?






48. What are the function of B cells?






49. IgG...






50. hat is the presentation of Jobs syndrome or Hyper IgE?