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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which antibody mediates immunity to worms? how?






2. ________ regulate the cell mediated response.






3. What are the main symptoms of T cell immunodeficiencies?






4. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






5. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






6. What is anergy? why does this occur?






7. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






8. What is an example of a parasite showing antigenic variation?






9. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






10. which antibodies can bind complement?






11. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






12. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






13. what cytokine does basophils secrete?






14. Which diseases are associated with DR4?






15. Which is the main antibody that provides passive immunity to infants?






16. What happens in a secondary follicle?






17. What are the autoantibodies for goodpastures syndrome?






18. What are the main cell surface proteins on B cells?






19. The secondary follicles have __________; primary follicles are dense






20. T/F B cells do not require a second signal






21. What are the autoantibodies for pemphigus bulgaris?






22. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






23. What is the clinical use for azathioprine?






24. is IgM an opsonizer?






25. which type of immunity is slow but long lasting? as opposed to...






26. What are the autoantibodies for pernicious anemia?






27. What is chronic mucocutaneous candidiasis d/t?






28. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






29. What is serum sickness? give an example.






30. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






31. What is the main function of IL 12? other than macrophages who else can release IL 12?






32. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






33. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






34. Type Iv hypersensitivity is...






35. How does the alternative pathway lead to MAC activation?






36. The two heavy chains of an antibody contribute to the...






37. What are the three types of lymphocytes?






38. What are the PALS?






39. The lymphocytes are ________ origin






40. Which HLA's are included in MHC I? MHC II?

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41. What is the pathology of acute transplant rejection? is it reversible?






42. What are some sinopulmonary infections?






43. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






44. IgE has the ___________ in the serum






45. What is the receptor for EBV? On what cells is that located?






46. What is epo used for?






47. The idiotype; the Fc portion determines the...






48. What do mature naive B lymphocytes express?






49. Complements are...






50. which cells have more complete tolerance - B or T cells?