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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. So antibodies are the effectors for the humoral response. List some of their functions.






2. What are the cell surface proteins on NK cells?






3. What is the defect in hyper IgM syndrome? What are the lab results?






4. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






5. what mediates the type II hypersensitivity? What are the two different methods?






6. IgM can exist as a _______ also






7. What are the two signals to kill for NK cells?






8. From where do cytokines come from?






9. What does interferon gamma do to be antiviral?






10. Which disease is associated withB B27?






11. What are MHC's necessary for? By themselves?






12. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






13. What is muromonab - CD3 (OKT3)






14. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






15. which B and T cell disorder presents with specifically low IgM?






16. Give an example of someone who could get hyperacute transplant rejection.






17. What are the main cell surface proteins on B cells?






18. What are the autoantibodies for polymyositis and dermatomyositis?






19. Name 5 ways Antibody diversity is generated?






20. What does Interferon alpha and beta do? how?






21. What is the late phase reaction of anaphylaxis allergy? what mediates it?






22. which antibodies can bind complement?






23. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






24. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






25. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






26. where do NK cells develop?






27. What kinds of receptors activate innate immunity?






28. What does IL 10 do? who is secreted by?






29. The ______ in the BM are DN - the DP are in the cortex of thymus






30. What does CD16 on NK cells do?






31. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






32. Type IV hypersensitivity is i...






33. what characterizes an arthus reaction?






34. What are the mediators that mast cells release?






35. Which helper T cells' development is induced by IL 4? IL 12?






36. What is the main function of interferons?






37. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






38. What is the main function of IL 12? other than macrophages who else can release IL 12?






39. What is the toxicity of muromonab?






40. What is the pathogenesis of a candida skin test?






41. which type of immunity is slow but long lasting? as opposed to...






42. Which disease is associated with HLA A3?






43. What are the PALS?






44. What happens in a secondary follicle?






45. Which disease is associated with DR7?






46. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






47. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






48. which antibody is involved in the primary response or immediate response to an antigen?






49. What are the two signals required for Th1 cells? what happens after then activated?






50. What are the major functions of Antibodies?