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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which antibody is involved in the primary response or immediate response to an antigen?






2. How do you test for type III hypersensitivity?






3. What are the symptoms of serum sickness?






4. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






5. What is the pathogenesis of acute transplant rejection? When does it occur?






6. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






7. what bacteria are a splenectomy patient most susceptible to? why?






8. What is the clinical use of Muromonab?






9. are Th cells involved in trapping of antigens of endotoxin/LPS?






10. What is the presentation of hyperIgM syndrome?






11. What are the two signals required for B cell class switching? Which is the second signal?






12. What happens in a deficiency of C3?






13. Which diseases are associated with DR4?






14. What lymph node drains the upper limb?






15. In thymic development - What is the positive selection? negative selections?






16. What is the white pulp of the spleen?






17. what cytokine does basophils secrete?






18. For which toxins are preformed antibodies (passive) given?






19. What is thrombopoietin used for?






20. What are the autoantibodies for systemic sclerosis?






21. What are the autoantibodies for pemphigus bulgaris?






22. Which HLA's are included in MHC I? MHC II?

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23. What is the pathology seen in chronic transplant rejection?






24. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






25. What lymph node drains the rectum (above the pectinate line)?






26. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






27. IgM can exist as a _______ also






28. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






29. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






30. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






31. What are the autoantibodies for myasthenia gravis?






32. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






33. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






34. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






35. in which immunodef order do you see a lot of pus? no pus?






36. Monomer in circulation - ___ when secreted






37. give an example of how influenza does a major antigenic shift.






38. is IgM an opsonizer?






39. What are the autoantibodies for pernicious anemia?






40. What is the pathology of acute transplant rejection? is it reversible?






41. What lymph node drains the lateral side of the dorsum of the foot?






42. The lymphocytes are ________ origin






43. The two heavy chains of an antibody contribute to the...






44. Which disease is associated with DR7?






45. Type IV hypersensitivity is i...






46. What are the main Cell surface proteins on T cells?






47. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






48. describe the pathogenesis of delayed type IV hypersensitivity






49. What type of side chains are found on Fc region of an antibody?






50. What is the marginal zone of the spleen? what happens there?







Sorry!:) No result found.

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