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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What does IgA pick up from epithelial cells before being secreted?






2. IgG...






3. What type of side chains are found on Fc region of an antibody?






4. What is the most common example of passive immunity?






5. How fast does it occur?






6. What are the two signals required for Th1 cells? what happens after then activated?






7. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






8. What type of fenestrations are found in the red pulp of the spleen?






9. What portion of the lymph node is not well developed in DiGeorge Syndrome?






10. Other than stimulating fever - what else does IL 6 do?






11. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






12. are Th cells involved in trapping of antigens of endotoxin/LPS?






13. What are target cells?






14. What cytokines are released by Th1 cells?






15. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






16. What does interferon gamma do? What two type of cells does it attack mostly?






17. What is recomb alpha interferon used for?






18. what will NK cells do to cells covered in IgG Ab? why?






19. What can cause a lymph node enlargement?






20. How does the alternative pathway lead to MAC activation?






21. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






22. What are the autoantibodies for wegeners granulomatosis?






23. What are the autoantibodies for drug induced lupus?






24. What happens in a secondary follicle?






25. which type of immunity is slow but long lasting? as opposed to...






26. Which disease is associated with DR7?






27. What is passive immunity?






28. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






29. What are the symptoms of serum sickness?






30. What are C1 - C2 - C3 - C4 important for?






31. A lymph node is a ________ lymphoid organ.






32. What are four results of a splenectomy?






33. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






34. what cell surface marker is used for NK cells as it is unique to them?






35. How do you test for type III hypersensitivity?






36. describe the classic complement pathway.






37. The lymphocytes are ________ origin






38. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






39. which antibodies prevent antigens from binding mucosal surfaces?






40. What is the mechanism for sirolimus? what else it known as?






41. what happens in a deficiency of C1 esterase inhibitor? DAF?






42. What are the two signals required for T cells? what happens after?






43. What is the main cytokine that activates eosinophils?






44. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






45. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






46. What is the main cytokine released by T cells? What does it do






47. What is the pathology of acute transplant rejection? is it reversible?






48. What are the autoantibodies for primary biliary cirrhosis?






49. can igG cross the placenta?






50. Describe the Mannose Lectin pathway







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