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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?

2. The lymphocytes are ________ origin

3. Which are the only two antiinflammatory cytokines?

4. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?

5. Which cytokines do Th2 release and For what?

6. What is the general structure of an Ab?

7. What is recomb beta interferon used for?

8. where are complements produced?

9. The ______ in the BM are DN - the DP are in the cortex of thymus

10. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?

11. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?

12. Which HLA's are included in MHC I? MHC II?

13. What is oprelevkin? and What is it used for?

14. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?

15. What is the late phase reaction of anaphylaxis allergy? what mediates it?

16. What is the marginal zone of the spleen? what happens there?

17. which of the transplant rejections is antibody mediated? why does it occur?

18. What is the pathology of acute transplant rejection? is it reversible?

19. What are the four steps in phagocytosis? What are the four disease that correspond to each step?

20. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?

21. In general What are T cells good for?

22. How is the antigen loaded onto a MHC II?

23. How does complement link innate and adaptive?

24. describe the classic complement pathway.

25. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?

26. How fast does it occur?

27. What lymph node drains the testes?

28. In thymic development - What is the positive selection? negative selections?

29. To what disease do the autoantibodies to IgG (rheumatoid factor)?

30. what cell surface marker is used for NK cells as it is unique to them?

31. What are the main cell surface proteins on B cells?

32. What are target cells?

33. which antibodies prevent antigens from binding mucosal surfaces?

34. what prevents NK cells from killing normal cells if their default is to kill?

35. What is hereditary angioedema? What are the C3 levels?

36. Describe the Mannose Lectin pathway

37. IgM can exist as a _______ also

38. What lymph node drains the sigmoid colon?

39. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?

40. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?

41. What is the main function of IL 8?

42. What is the pathogenesis of acute transplant rejection? When does it occur?

43. Which diseases are associated with DR5?

44. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?

45. Describe the capsular structure of a lymph node; What are the functions of the LN?

46. when can graft versus host disease? What is the result?

47. What is the white pulp of the spleen?

48. What is the most common example of passive immunity?

49. A lymph node is a ________ lymphoid organ.

50. which cytokine inhibits TH2 cells? secreted by who?