Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are howell jolly bodies?






2. which cytokine inhibits TH2 cells? secreted by who?






3. What are the autoantibodies for myasthenia gravis?






4. What are the autoantibodies for pemphigus bulgaris?






5. What is the main function of IL 12? other than macrophages who else can release IL 12?






6. what will NK cells do to cells covered in IgG Ab? why?






7. What is the presentation of Brutons agammaglobulinemia?






8. What is thrombopoietin used for?






9. Which cytokines do Th2 release and For what?






10. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






11. T/F B cells do not require a second signal






12. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






13. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






14. What is the toxicity of azathioprine?






15. What does it mean if there are igM in the serum at birth?






16. Which disease is associated with B8?






17. What is three common causes of severe combined immunodef? What is the result of all three?






18. which type of immunity is slow but long lasting? as opposed to...






19. In general What are T cells good for?






20. What are the major functions of Antibodies?






21. what mediates the type II hypersensitivity? What are the two different methods?






22. What is filgrastim and sargramostim? and What is it used for?






23. where do somatic hypermutation and class switching occur?






24. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






25. What are MHC's necessary for? By themselves?






26. What are the autoantibodies for hashimotos?






27. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






28. What are the autoantibodies for other vasculitides?






29. What does CD16 on NK cells do?






30. IgE has the ___________ in the serum






31. What can cause a lymph node enlargement?






32. give an example of how influenza does a major antigenic shift.






33. What are the T cell functions?






34. What is anergy? why does this occur?






35. what bacteria are a splenectomy patient most susceptible to? why?






36. what results in symptoms of shock in an acute hemolytic transfusion reaction?






37. What are C1 - C2 - C3 - C4 important for?






38. What type of side chains are found on Fc region of an antibody?






39. IgM can exist as a _______ also






40. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






41. What is the general structure of an Ab?






42. What links the adaptive and innate immunity?






43. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






44. Which helper T cells' development is induced by IL 4? IL 12?






45. Which is the most abundant antibody in blood?






46. What is the autoantibody for SLE that is nonspecific? Specific?






47. To what portion of the Antibody do the complements bind?






48. Describe the Mannose Lectin pathway






49. What is the pathogenesis of a candida skin test?






50. Monomer in circulation - ___ when secreted