Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which are the only two antiinflammatory cytokines?






2. What kinds of receptors activate innate immunity?






3. Only the _______ contribute to the Fc region






4. What are the PALS?






5. What is the marginal zone of the spleen? what happens there?






6. What is recomb beta interferon used for?






7. what results in symptoms of shock in an acute hemolytic transfusion reaction?






8. What is the white pulp of the spleen?






9. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






10. Describe the capsular structure of a lymph node; What are the functions of the LN?






11. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






12. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






13. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






14. What does IL 4 do?






15. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






16. What lymph node drains the scrotum?






17. Complements are...






18. What are the autoantibodies for Mixed connective tissue disease?






19. What are superantigens? give two examples.






20. For which toxins are preformed antibodies (passive) given?






21. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






22. How does igA cross the epithelium?






23. which interleukin receptor is required for NK development? activation?






24. What is the cause of thymic aplasia? What is its presentation? What are the labs?






25. Which cytokines do Th2 release and For what?






26. What are the autoantibodies for sjorgens syndrome?






27. What are the autoantibodies for primary biliary cirrhosis?






28. How is the antigen loaded onto a MHC II?






29. what secretes IL 4?






30. How do you test for chronic granulomatous disease?






31. The lymphocytes are ________ origin






32. What is the clinical use for azathioprine?






33. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






34. Which diseases are associated with DR4?






35. What is Aldesleukin? What is it used for






36. What lymph node drains the lateral side of the dorsum of the foot?






37. ________ regulate the cell mediated response.






38. How fast does it occur?






39. The alternative pathway is the only constutively...






40. What is the toxicity of muromonab?






41. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






42. when can graft versus host disease? What is the result?






43. What is the main cytokine that activates eosinophils?






44. The ______ in the BM are DN - the DP are in the cortex of thymus






45. What is the pathology in hyperacute transplant rejection?






46. What is a type I hypersensitivity reaction? What is atopic?






47. What are the autoantibodies for pemphigus bulgaris?






48. What are the autoantibodies for other vasculitides?






49. To what portion of the Antibody do the complements bind?






50. What lymph node drains the breast?