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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Leukocyte adhesion defect presents with...






2. Which disease is associated withB B27?






3. are Th cells involved in trapping of antigens of endotoxin/LPS?






4. What does Interferon alpha and beta do? how?






5. what ensure that a memory response is generated?






6. which of the transplant rejections is antibody mediated? why does it occur?






7. What are C1 - C2 - C3 - C4 important for?






8. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






9. is IgM an opsonizer?






10. What is the general structure of an Ab?






11. The two heavy chains of an antibody contribute to the...






12. What happens in a deficiency of C3?






13. Which HLA's are included in MHC I? MHC II?

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14. What are the cell surface proteins for Macrophages? which two are for opsonins?






15. What does IL 5 do?






16. What is the presentation of Brutons agammaglobulinemia?






17. What do mature naive B lymphocytes express?






18. Describe the complement independent Type II hypersenstivity reaction. Give an example.






19. So antibodies are the effectors for the humoral response. List some of their functions.






20. What does interferon gamma do? What two type of cells does it attack mostly?






21. The MALT/GALT are not...






22. Monomer in circulation - ___ when secreted






23. What are the cell surface proteins on NK cells?






24. What are the autoantibodies for systemic sclerosis?






25. What are the main cell surface proteins on B cells?






26. What cytokines are released by Th1 cells?






27. what secretes IL 4?






28. What are the autoantibodies for polymyositis and dermatomyositis?






29. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






30. What lymph node drains the duodenum - jejunum?






31. what cell surface marker is used for NK cells as it is unique to them?






32. What are the two signals required for T cells? what happens after?






33. What is passive immunity?






34. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






35. Give an example of someone who could get hyperacute transplant rejection.






36. Name the three opsonins






37. In general What are T cells good for?






38. What do multimeric antibodies require for assembly?






39. What are some catalase positive organisms?






40. What are four results of a splenectomy?






41. What bugs can actually infect the lymph node itself?






42. What are the autoantibodies for myasthenia gravis?






43. Which diseases are associated with DR4?






44. which B and T cell disorder presents with specifically low IgM?






45. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






46. Which is the main antibody in the delayed or secondary response to an antigen?






47. what cytokine does basophils secrete?






48. What is the mechanism for sirolimus? what else it known as?






49. What does interferon gamma do to be antiviral?






50. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?







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