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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






2. What is the pathology of acute transplant rejection? is it reversible?






3. The pathogenesis of contact dermatitis is ________ hypersensitivity






4. What is Aldesleukin? What is it used for






5. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






6. IgG...






7. What are the mediators that mast cells release?






8. The idiotype; the Fc portion determines the...






9. What are superantigens? give two examples.






10. How do you test for type III hypersensitivity?






11. What lymph node drains the lateral side of the dorsum of the foot?






12. Describe the capsular structure of a lymph node; What are the functions of the LN?






13. What are the two signals required for Th1 cells? what happens after then activated?






14. What kinds of receptors activate innate immunity?






15. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






16. What is the main function of IL 12? other than macrophages who else can release IL 12?






17. give an example of how influenza does a major antigenic shift.






18. when can graft versus host disease? What is the result?






19. What is the main function of TNF alpha? How does it do this?






20. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






21. What are the function of B cells?






22. hat is the presentation of Jobs syndrome or Hyper IgE?






23. What is the toxicity of azathioprine?






24. What is the clinical use of Muromonab?






25. What are the autoantibodies for wegeners granulomatosis?






26. What is anergy? why does this occur?






27. What are the main Cell surface proteins on T cells?






28. what prevents NK cells from killing normal cells if their default is to kill?






29. What lymph node drains the thigh?






30. what happens in a deficiency of C1 esterase inhibitor? DAF?






31. What are the autoantibodies for polymyositis and dermatomyositis?






32. Which helper T cells' development is induced by IL 4? IL 12?






33. IgM can exist as a _______ also






34. What type of side chains are found on Fc region of an antibody?






35. To what disease do the autoantibodies to IgG (rheumatoid factor)?






36. Describe the Mannose Lectin pathway






37. What is the marginal zone of the spleen? what happens there?






38. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






39. What can cause a lymph node enlargement?






40. Which disease is associated with DR7?






41. what cell surface proteins are on all APCs?






42. in which immunodef order do you see a lot of pus? no pus?






43. T/F B cells do not require a second signal






44. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






45. What is the pathogenesis of HyperIgE syndrome? What are the labs?






46. What is the pathogenesis of a hypersensitivity reaction?






47. Give three examples of bacteria that use antigenic variation and how.






48. What lymph node drains the stomach?






49. The MALT/GALT are not...






50. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).