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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






2. Which HLA's are included in MHC I? MHC II?

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3. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






4. T/F B cells do not require a second signal






5. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






6. What is recomb beta interferon used for?






7. What lymph node drains the sigmoid colon?






8. How fast does it occur?






9. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






10. What is the clinical use for sirolimus? what should you combine it with?






11. What happens in a deficiency of C3?






12. What are the autoantibodies for primary biliary cirrhosis?






13. What are the autoantibodies for hashimotos?






14. What are the three types of APCs?






15. What is the pathology in hyperacute transplant rejection?






16. when can graft versus host disease? What is the result?






17. The idiotype; the Fc portion determines the...






18. in which immunodef order do you see a lot of pus? no pus?






19. What is a factor that is a predictor for a bad transplantation?






20. which antibody is involved in the primary response or immediate response to an antigen?






21. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






22. Leukocyte adhesion defect presents with...






23. What is the general structure of an Ab?






24. describe the pathogenesis of delayed type IV hypersensitivity






25. To what disease do the autoantibodies to IgG (rheumatoid factor)?






26. Which diseases are associated with DR4?






27. What are the symptoms of serum sickness?






28. A lymph node is a ________ lymphoid organ.






29. What are the PALS?






30. In thymic development - What is the positive selection? negative selections?






31. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






32. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






33. What are the main cell surface proteins on B cells?






34. How is the thymus organized? what happens in each section?






35. What is the pathogenesis of HyperIgE syndrome? What are the labs?






36. What are the autoantibodies for goodpastures syndrome?






37. which cytokine inhibits TH2 cells? secreted by who?






38. What are the main Cell surface proteins on T cells?






39. The MALT/GALT are not...






40. what ensure that a memory response is generated?






41. What is the common variable immunodeficiency ? How is it different from Brutons?






42. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






43. What is the receptor for EBV? On what cells is that located?






44. What is the most common selective Ig deficiency? What is the presentation?






45. The lymphocytes are ________ origin






46. Which is the main antibody in the delayed or secondary response to an antigen?






47. What does interferon gamma do? What two type of cells does it attack mostly?






48. What is the autoantibody for SLE that is nonspecific? Specific?






49. What is the main function of TNF alpha? How does it do this?






50. What does Interferon alpha and beta do? how?






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