Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what secretes IL 4?






2. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






3. What are the autoantibodies for autoimmune hepatitis?






4. What is a type I hypersensitivity reaction? What is atopic?






5. What can cause a lymph node enlargement?






6. The Fc region is found on the...






7. Describe complement dependent Type II hypersensitivity. Give an example.






8. What does granzyme do? who secretes it?






9. __________ are a part of the innate system.






10. What does IL 4 do?






11. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






12. What is recomb alpha interferon used for?






13. Describe the Mannose Lectin pathway






14. What are the autoantibodies for pemphigus bulgaris?






15. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






16. IgE has the ___________ in the serum






17. Name two endogenous pyrogens






18. Describe the complement independent Type II hypersenstivity reaction. Give an example.






19. What are the two signals to kill for NK cells?






20. which antibody is involved in the primary response or immediate response to an antigen?






21. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






22. What lymph node drains the testes?






23. What is the main cytokine that activates eosinophils?






24. What is the toxicity of muromonab?






25. What are the cell surface proteins on NK cells?






26. What is colostrum?






27. can igG cross the placenta?






28. What happens in a deficiency of C3?






29. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






30. What happens in a secondary follicle?






31. Which antibody mediates immunity to worms? how?






32. What is the mechanism for sirolimus? what else it known as?






33. The two heavy chains of an antibody contribute to the...






34. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






35. which cells have more complete tolerance - B or T cells?






36. What are the autoantibodies for graves?






37. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






38. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






39. What is the toxicity of azathioprine?






40. What is epo used for?






41. What is the main function of IL 8?






42. The lymphocytes are ________ origin






43. How do you test for type III hypersensitivity?






44. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






45. What is the pathogenesis of HyperIgE syndrome? What are the labs?






46. IgM can exist as a _______ also






47. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






48. which interleukin receptor is required for NK development? activation?






49. How do you test for chronic granulomatous disease?






50. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?