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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






2. What happens in a deficiency of C3?






3. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






4. What is the marginal zone of the spleen? what happens there?






5. To what disease do the autoantibodies to IgG (rheumatoid factor)?






6. Which disease is associated with B8?






7. What is the common variable immunodeficiency ? How is it different from Brutons?






8. where do somatic hypermutation and class switching occur?






9. What is oprelevkin? and What is it used for?






10. What happens in a secondary follicle?






11. other than C3a - what other complement acts as an anaphyloxin?






12. What does CD16 on NK cells do?






13. give an example of how influenza does a major antigenic shift.






14. Other than stimulating fever - what else does IL 6 do?






15. What is the pathogenesis of HyperIgE syndrome? What are the labs?






16. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






17. What lymph node drains the lateral side of the dorsum of the foot?






18. What is the general structure of an Ab?






19. Type IV hypersensitivity is i...






20. What are the autoantibodies for goodpastures syndrome?






21. what prevents NK cells from killing normal cells if their default is to kill?






22. what mediates the type II hypersensitivity? What are the two different methods?






23. What lymph node drains the sigmoid colon?






24. What is the toxicity of azathioprine?






25. ________ regulate the cell mediated response.






26. What is the pathology in hyperacute transplant rejection?






27. The lymphocytes are ________ origin






28. What are the major functions of Antibodies?






29. which antibodies can bind complement?






30. Describe the complement independent Type II hypersenstivity reaction. Give an example.






31. what will NK cells do to cells covered in IgG Ab? why?






32. What does IgA pick up from epithelial cells before being secreted?






33. Which disease is associated with DR7?






34. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






35. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






36. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






37. In thymic development - What is the positive selection? negative selections?






38. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






39. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






40. What are the cell surface proteins on NK cells?






41. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






42. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






43. What does Interferon alpha and beta do? how?






44. What is serum sickness? give an example.






45. which of the transplant rejections is antibody mediated? why does it occur?






46. What is the main cytokine released by T cells? What does it do






47. What is digoxin immune Fab used for?






48. What is Aldesleukin? What is it used for






49. IgE has the ___________ in the serum






50. other than mediating shock - what else does TNF alpha do? who releases it mainly?