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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The Fc region is found on the...






2. where are complements produced?






3. The lymphocytes are ________ origin






4. Which antibodies can be multimeric?






5. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






6. What lymph node drains the anal canal (below the pectinate line)?






7. what happens in order for class switching to occur (after being activated by IL and cd40 L)?






8. What is the marginal zone of the spleen? what happens there?






9. What portion of the lymph node is not well developed in DiGeorge Syndrome?






10. What are target cells?






11. What is the general structure of an Ab?






12. Leukocyte adhesion defect presents with...






13. What are howell jolly bodies?






14. What cytokines to Th2 secrete?






15. Which type of selection of thymic development provides central tolerance?






16. What is the main function of IL 12? other than macrophages who else can release IL 12?






17. T/F B cells do not require a second signal






18. What is the receptor for EBV? On what cells is that located?






19. What is the most common selective Ig deficiency? What is the presentation?






20. what happens in a deficiency of C1 esterase inhibitor? DAF?






21. What does IL 4 do?






22. What is the main function of TNF alpha? How does it do this?






23. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






24. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






25. Give three examples of bacteria that use antigenic variation and how.






26. What is hereditary angioedema? What are the C3 levels?






27. What does CD16 on NK cells do?






28. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






29. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






30. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






31. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






32. What is the late phase reaction of anaphylaxis allergy? what mediates it?






33. What are the autoantibodies for pemphigus bulgaris?






34. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






35. What type of side chains are found on Fc region of an antibody?






36. What is a factor that is a predictor for a bad transplantation?






37. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






38. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






39. hat is the presentation of Jobs syndrome or Hyper IgE?






40. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






41. what cell surface proteins are on all APCs?






42. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






43. Which is the main antibody in the delayed or secondary response to an antigen?






44. Which disease is associated with HLA A3?






45. IgM can fix complement but...






46. What is the presentation of Brutons agammaglobulinemia?






47. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






48. What is the common variable immunodeficiency ? How is it different from Brutons?






49. What is chronic mucocutaneous candidiasis d/t?






50. What is the main function of interferons?