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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the main symptoms of B cell immunodeficiencies?






2. Which MHC presents intracellular peptides? how so?






3. other than eat and bite RBCs what else do Macrophages of spleen do>






4. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






5. What is the common variable immunodeficiency ? How is it different from Brutons?






6. What is the most common example of passive immunity?






7. which antibodies can bind complement?






8. Which disease is associated with HLA A3?






9. which antibody is involved in the primary response or immediate response to an antigen?






10. which antibodies prevent antigens from binding mucosal surfaces?






11. The idiotype; the Fc portion determines the...






12. which cytokine inhibits TH2 cells? secreted by who?






13. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






14. What are the main cell surface proteins on B cells?






15. What are the T cell functions?






16. What lymph node drains the rectum (above the pectinate line)?






17. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






18. What cytokines are released by Th1 cells?






19. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






20. Name the three opsonins






21. What happens in a secondary follicle?






22. What is an example of a parasite showing antigenic variation?






23. What is the main function of IL 12? other than macrophages who else can release IL 12?






24. What are howell jolly bodies?






25. hat is the presentation of Jobs syndrome or Hyper IgE?






26. How do you test for type III hypersensitivity?






27. The MALT/GALT are not...






28. What is the receptor for EBV? On what cells is that located?






29. what cell surface proteins are on all APCs?






30. What is the defect in hyper IgM syndrome? What are the lab results?






31. Which is the main antibody that provides passive immunity to infants?






32. __________ are a part of the innate system.






33. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






34. How is i Th1 helper cell inhibited?






35. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






36. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






37. what prevents NK cells from killing normal cells if their default is to kill?






38. What is the clinical use of Muromonab?






39. What do mature naive B lymphocytes express?






40. are Th cells involved in trapping of antigens of endotoxin/LPS?






41. What is the pathogenesis of a candida skin test?






42. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






43. where are complements produced?






44. What is oprelevkin? and What is it used for?






45. Name 5 ways Antibody diversity is generated?






46. which antibody activate mast cells - basophils - and eosinophils?






47. How fast does it occur?






48. IgM can exist as a _______ also






49. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






50. IgG...