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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what prevents NK cells from killing normal cells if their default is to kill?






2. What does granulysin do?






3. What are the two signals required for T cells? what happens after?






4. What is oprelevkin? and What is it used for?






5. are Th cells involved in trapping of antigens of endotoxin/LPS?






6. Name the three opsonins






7. What are howell jolly bodies?






8. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






9. IgM can fix complement but...






10. What is the marginal zone of the spleen? what happens there?






11. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






12. What is the cause of thymic aplasia? What is its presentation? What are the labs?






13. what cytokine does basophils secrete?






14. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






15. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






16. Which are the only two antiinflammatory cytokines?






17. What are the autoantibodies for wegeners granulomatosis?






18. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






19. Which disease is associated withB B27?






20. What are the autoantibodies for myasthenia gravis?






21. What is epo used for?






22. other than mediating shock - what else does TNF alpha do? who releases it mainly?






23. Describe the Mannose Lectin pathway






24. what bacteria are a splenectomy patient most susceptible to? why?






25. How does the alternative pathway lead to MAC activation?






26. which of the transplant rejections is antibody mediated? why does it occur?






27. Which is the main antibody that provides passive immunity to infants?






28. What is thrombopoietin used for?






29. What is the pathogenesis of a hypersensitivity reaction?






30. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






31. From where do cytokines come from?






32. which cells have more complete tolerance - B or T cells?






33. Which disease is associated with B8?






34. What are the function of B cells?






35. Give an example of someone who could get hyperacute transplant rejection.






36. which interleukin receptor is required for NK development? activation?






37. What is the pathology of acute transplant rejection? is it reversible?






38. What are four results of a splenectomy?






39. Give three examples of bacteria that use antigenic variation and how.






40. What is the most common example of passive immunity?






41. What is immune complex disease? give an example.






42. What do multimeric antibodies require for assembly?






43. what characterizes an arthus reaction?






44. What are the three types of APCs?






45. Which disease is associated with DR3?






46. What are the autoantibodies for primary biliary cirrhosis?






47. which of the hypersensitivity reactions is not Ab mediated?






48. What links the adaptive and innate immunity?






49. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






50. All transplant rejections - _____________ are mediated by Type IV hypersensitivity