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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the PALS?






2. What is the autoantibody for SLE that is nonspecific? Specific?






3. What is serum sickness? give an example.






4. What is hereditary angioedema? What are the C3 levels?






5. What are the T cell functions?






6. what bacteria are a splenectomy patient most susceptible to? why?






7. Which is the most abundant antibody in blood?






8. What are the function of B cells?






9. what mediates the type II hypersensitivity? What are the two different methods?






10. What does interferon gamma do to be antiviral?






11. IgG...






12. What is the pathogenesis of a candida skin test?






13. What is the main function of TNF alpha? How does it do this?






14. Monomer in circulation - ___ when secreted






15. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






16. what characterizes an arthus reaction?






17. What do multimeric antibodies require for assembly?






18. which B and T cell disorder presents with specifically low IgM?






19. The pathogenesis of contact dermatitis is ________ hypersensitivity






20. What are the mediators that mast cells release?






21. Which diseases are associated with DR4?






22. The idiotype; the Fc portion determines the...






23. What is Aldesleukin? What is it used for






24. which of the transplant rejections is antibody mediated? why does it occur?






25. Which disease is associated withB B27?






26. What are superantigens? give two examples.






27. What is the white pulp of the spleen?






28. What are the main symptoms of B cell immunodeficiencies?






29. is IgM an opsonizer?






30. What are the two signals required for Th1 cells? what happens after then activated?






31. How does igA cross the epithelium?






32. what cytokine does basophils secrete?






33. What is the most common selective Ig deficiency? What is the presentation?






34. What is the pathology in hyperacute transplant rejection?






35. What is the general structure of an Ab?






36. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






37. What are the autoantibodies for myasthenia gravis?






38. How is the antigen loaded onto a MHC II?






39. What does interferon gamma do? What two type of cells does it attack mostly?






40. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






41. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






42. can igG cross the placenta?






43. What is immune complex disease? give an example.






44. What is recomb alpha interferon used for?






45. The two heavy chains of an antibody contribute to the...






46. What does CD16 on NK cells do?






47. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






48. which type of immunity is slow but long lasting? as opposed to...






49. The Fc region is found on the...






50. ________ regulate the cell mediated response.






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