Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How is sirolimus different from tacrolimus?






2. What does interferon gamma do to be antiviral?






3. What are the autoantibodies for wegeners granulomatosis?






4. What are the two signals to kill for NK cells?






5. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






6. hat is the presentation of Jobs syndrome or Hyper IgE?






7. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






8. Which disease is associated with DR7?






9. How do you test for type III hypersensitivity?






10. The Fc region is found on the...






11. What is the pathogenesis of HyperIgE syndrome? What are the labs?






12. What lymph node drains the upper limb?






13. The ______ in the BM are DN - the DP are in the cortex of thymus






14. what happens in a deficiency of C1 esterase inhibitor? DAF?






15. What are the autoantibodies for polymyositis and dermatomyositis?






16. What does IL 2 do?






17. __________ are a part of the innate system.






18. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






19. what ensure that a memory response is generated?






20. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






21. Which disease is associated with DR3?






22. What is the main function of interferons?






23. How is i Th1 helper cell inhibited?






24. What is the main cytokine released by T cells? What does it do






25. Which disease is associated withB B27?






26. Describe complement dependent Type II hypersensitivity. Give an example.






27. To what portion of the Antibody do the complements bind?






28. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






29. what cell surface marker is used for NK cells as it is unique to them?






30. What is filgrastim and sargramostim? and What is it used for?






31. What is muromonab - CD3 (OKT3)






32. So antibodies are the effectors for the humoral response. List some of their functions.






33. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






34. Which helper T cells' development is induced by IL 4? IL 12?






35. where do NK cells develop?






36. What is the most common selective Ig deficiency? What is the presentation?






37. What portion of the lymph node is not well developed in DiGeorge Syndrome?






38. what characterizes an arthus reaction?






39. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






40. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






41. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






42. What is oprelevkin? and What is it used for?






43. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






44. what will NK cells do to cells covered in IgG Ab? why?






45. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






46. What lymph node drains the scrotum?






47. What are the main symptoms of T cell immunodeficiencies?






48. What are the autoantibodies for pernicious anemia?






49. Name the three opsonins






50. Which antibodies can be multimeric?