Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do you test for type III hypersensitivity?






2. which of the transplant rejections is antibody mediated? why does it occur?






3. What lymph node drains the scrotum?






4. in which immunodef order do you see a lot of pus? no pus?






5. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






6. Which is the main antibody in the delayed or secondary response to an antigen?






7. What are the cell surface proteins on NK cells?






8. To what portion of the Antibody do the complements bind?






9. Name the three opsonins






10. other than C3a - what other complement acts as an anaphyloxin?






11. What are the cell surface proteins for Macrophages? which two are for opsonins?






12. What are the autoantibodies for goodpastures syndrome?






13. What bugs can actually infect the lymph node itself?






14. What is recomb beta interferon used for?






15. Which MHC presents intracellular peptides? how so?






16. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






17. which cytokine inhibits TH2 cells? secreted by who?






18. What is the defect in hyper IgM syndrome? What are the lab results?






19. What are the autoantibodies for sjorgens syndrome?






20. What kinds of receptors activate innate immunity?






21. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






22. What happens in a secondary follicle?






23. What are the two signals required for B cell class switching? Which is the second signal?






24. What is the common variable immunodeficiency ? How is it different from Brutons?






25. where are complements produced?






26. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






27. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






28. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






29. Which disease is associated with DR7?






30. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1






31. The MALT/GALT are not...






32. Which type of selection of thymic development provides central tolerance?






33. Which antibody mediates immunity to worms? how?






34. What is digoxin immune Fab used for?






35. What type of side chains are found on Fc region of an antibody?






36. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






37. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






38. What happens in a deficiency of C3?






39. To what disease do the autoantibodies to IgG (rheumatoid factor)?






40. What are the two signals required for T cells? what happens after?






41. What is the pathology seen in chronic transplant rejection?






42. describe the pathogenesis of delayed type IV hypersensitivity






43. What is the pathology in hyperacute transplant rejection?






44. What is the clinical use of Muromonab?






45. Which antibodies can be multimeric?






46. What do mature naive B lymphocytes express?






47. What does IL 10 do? who is secreted by?






48. What are C1 - C2 - C3 - C4 important for?






49. What is the main function of TNF alpha? How does it do this?






50. What lymph node drains the anal canal (below the pectinate line)?