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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






2. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






3. What are the three types of lymphocytes?






4. What is oprelevkin? and What is it used for?






5. What is the pathogenesis of a candida skin test?






6. What is the autoantibody for SLE that is nonspecific? Specific?






7. What are the symptoms of serum sickness?






8. In general What are T cells good for?






9. What is digoxin immune Fab used for?






10. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






11. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






12. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






13. What is the most common selective Ig deficiency? What is the presentation?






14. What does IL 5 do?






15. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






16. Which diseases are associated with DR4?






17. What are the two signals to kill for NK cells?






18. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






19. What is hereditary angioedema? What are the C3 levels?






20. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






21. What is Aldesleukin? What is it used for






22. What is an example of a parasite showing antigenic variation?






23. Name 5 ways Antibody diversity is generated?






24. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






25. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






26. What are four results of a splenectomy?






27. when can graft versus host disease? What is the result?






28. What are the T cell functions?






29. What are the autoantibodies for sjorgens syndrome?






30. What lymph node drains the testes?






31. Which is the main antibody in the delayed or secondary response to an antigen?






32. __________ are a part of the innate system.






33. What is the main function of IL 8?






34. What is the clinical use of Muromonab?






35. What does granzyme do? who secretes it?






36. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






37. What cytokines to Th2 secrete?






38. What portion of the lymph node is not well developed in DiGeorge Syndrome?






39. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






40. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






41. are Th cells involved in trapping of antigens of endotoxin/LPS?






42. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






43. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






44. What is the clinical use for azathioprine?






45. what secretes IL 4?






46. which type of immunity is slow but long lasting? as opposed to...






47. What is a type I hypersensitivity reaction? What is atopic?






48. What are the two signals required for B cell class switching? Which is the second signal?






49. What are target cells?






50. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?