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USMLE Step 1 Immunology

  • Answer 50 questions in 15 minutes.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?

2. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?

3. Which type of selection of thymic development provides central tolerance?

4. what bacteria are a splenectomy patient most susceptible to? why?

5. What does IL 5 do?

6. What is passive immunity?

7. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?

8. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?

9. What is the mechanism for sirolimus? what else it known as?

10. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?

11. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?

12. The secondary follicles have __________; primary follicles are dense

13. Which cytokines do Th2 release and For what?

14. Name three things that IL 1 does as a cytokine. other than the liver - who secretes IL 1

15. What is an example of a parasite showing antigenic variation?

16. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>

17. What is colostrum?

18. What are the autoantibodies for systemic sclerosis?

19. Only the _______ contribute to the Fc region

20. What does granulysin do?

21. What is the pathology in hyperacute transplant rejection?

22. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.

23. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?

24. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?

25. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?

26. Describe the capsular structure of a lymph node; What are the functions of the LN?

27. which interleukin receptor is required for NK development? activation?

28. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction

29. What are howell jolly bodies?

30. What lymph node drains the testes?

31. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example

32. What lymph node drains the rectum (above the pectinate line)?

33. What are the main symptoms of B cell immunodeficiencies?

34. describe the classic complement pathway.

35. What is the pathology seen in chronic transplant rejection?

36. A lymph node is a ________ lymphoid organ.

37. What is epo used for?

38. give an example of how influenza does a major antigenic shift.

39. Which are the only two antiinflammatory cytokines?

40. What is hereditary angioedema? What are the C3 levels?

41. What is the white pulp of the spleen?

42. What are MHC's necessary for? By themselves?

43. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?

44. Which antibodies can be multimeric?

45. where do NK cells develop?

46. What are the autoantibodies for primary biliary cirrhosis?

47. in which immunodef order do you see a lot of pus? no pus?

48. What is the presentation of hyperIgM syndrome?

49. What lymph node drains the thigh?

50. What is the end result of complement activation? what bugs are this important for? through what pathway and why?