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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






2. what prevents NK cells from killing normal cells if their default is to kill?






3. What happens in a secondary follicle?






4. The Fc region is found on the...






5. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






6. when can graft versus host disease? What is the result?






7. Name two endogenous pyrogens






8. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






9. What is the presentation of Brutons agammaglobulinemia?






10. What is the pathogenesis of a hypersensitivity reaction?






11. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






12. where are complements produced?






13. Which antibody mediates immunity to worms? how?






14. What lymph node drains the scrotum?






15. What does it mean if there are igM in the serum at birth?






16. What are the autoantibodies for goodpastures syndrome?






17. __________ are a part of the innate system.






18. What is the marginal zone of the spleen? what happens there?






19. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






20. What are the symptoms of serum sickness?






21. Which disease is associated withB B27?






22. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






23. What lymph node drains the sigmoid colon?






24. Leukocyte adhesion defect presents with...






25. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






26. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






27. is IgM an opsonizer?






28. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






29. What lymph node drains the rectum (above the pectinate line)?






30. What does Interferon alpha and beta do? how?






31. What are the autoantibodies for systemic sclerosis?






32. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






33. For which toxins are preformed antibodies (passive) given?






34. What lymph node drains the duodenum - jejunum?






35. What is the pathology of acute transplant rejection? is it reversible?






36. Which cytokines do Th2 release and For what?






37. What are the autoantibodies for Celiac disease?






38. What are the main symptoms of T cell immunodeficiencies?






39. What links the adaptive and innate immunity?






40. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






41. Which antibodies can be multimeric?






42. What is the treatment of acute transplant rejection?






43. hat is the presentation of Jobs syndrome or Hyper IgE?






44. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






45. What are the autoantibodies for other vasculitides?






46. what characterizes an arthus reaction?






47. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






48. What is hereditary angioedema? What are the C3 levels?






49. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






50. What is an example of a parasite showing antigenic variation?






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