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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do you test for chronic granulomatous disease?






2. Which disease is associated with DR7?






3. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






4. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






5. Which MHC presents intracellular peptides? how so?






6. What is anergy? why does this occur?






7. What is the mechanism for sirolimus? what else it known as?






8. Describe complement dependent Type II hypersensitivity. Give an example.






9. The lymphocytes are ________ origin






10. What type of fenestrations are found in the red pulp of the spleen?






11. What does granzyme do? who secretes it?






12. other than C3a - what other complement acts as an anaphyloxin?






13. From where do cytokines come from?






14. What do multimeric antibodies require for assembly?






15. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






16. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






17. How is i Th1 helper cell inhibited?






18. The idiotype; the Fc portion determines the...






19. which B and T cell disorder presents with specifically low IgM?






20. What is the autoantibody for SLE that is nonspecific? Specific?






21. What are the three types of APCs?






22. in which immunodef order do you see a lot of pus? no pus?






23. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






24. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






25. which type of immunity is slow but long lasting? as opposed to...






26. What are the two signals required for Th1 cells? what happens after then activated?






27. Which type of selection of thymic development provides central tolerance?






28. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






29. What is the presentation of hyperIgM syndrome?






30. What is the white pulp of the spleen?






31. In order to produce Antibodies - does the antigen have to be phagocytosed? give an example with a bug and an autoimmune (type II hypersensitivity for example).






32. What is thrombopoietin used for?






33. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






34. What are the autoantibodies for Celiac disease?






35. For which toxins are preformed antibodies (passive) given?






36. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






37. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






38. What is the pathology in hyperacute transplant rejection?






39. What is the common variable immunodeficiency ? How is it different from Brutons?






40. other than mediating shock - what else does TNF alpha do? who releases it mainly?






41. What is passive immunity?






42. What is the presentation of common variable immunodef? and What are the labs?






43. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






44. What is the antimetabolite precursor of 6 mercaptopurine? What is the result?






45. which cytokine inhibits TH2 cells? secreted by who?






46. To what portion of the Antibody do the complements bind?






47. What are the autoantibodies for other vasculitides?






48. Only the _______ contribute to the Fc region






49. Which is the most abundant antibody in blood?






50. What is the presentation of scid? treatment?