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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






2. What are the three types of Type III hypersensitivity ? What is the common mechanism between them?






3. What is the main function of interferons?






4. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






5. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






6. What are the autoantibodies for autoimmune hepatitis?






7. What is the most common selective Ig deficiency? What is the presentation?






8. which of the transplant rejections is antibody mediated? why does it occur?






9. To what disease do the autoantibodies to IgG (rheumatoid factor)?






10. What is Aldesleukin? What is it used for






11. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






12. which cytokine inhibits TH2 cells? secreted by who?






13. which antibodies prevent antigens from binding mucosal surfaces?






14. What are the symptoms of serum sickness?






15. Which MHC presents intracellular peptides? how so?






16. What does granzyme do? who secretes it?






17. What is the mechanism for sirolimus? what else it known as?






18. What are the two signals to kill for NK cells?






19. What does it mean if there are igM in the serum at birth?






20. What are the two signals required for T cells? what happens after?






21. What is the pathogenesis of a candida skin test?






22. What is the pathogenesis of a hypersensitivity reaction?






23. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






24. What happens in a secondary follicle?






25. The Fc region is found on the...






26. How is the thymus organized? what happens in each section?






27. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






28. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






29. __________ are a part of the innate system.






30. What is the pathology in hyperacute transplant rejection?






31. What does granulysin do?






32. Which diseases are associated with DR2?






33. What are the three types of lymphocytes?






34. What is serum sickness? give an example.






35. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






36. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






37. ________ regulate the cell mediated response.






38. Which disease is associated with HLA A3?






39. what ensure that a memory response is generated?






40. What lymph node drains the scrotum?






41. What are the autoantibodies for polymyositis and dermatomyositis?






42. What are the autoantibodies for hashimotos?






43. What is epo used for?






44. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






45. The secondary follicles have __________; primary follicles are dense






46. What does IgA pick up from epithelial cells before being secreted?






47. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






48. Give an example of someone who could get hyperacute transplant rejection.






49. What are the autoantibodies for type I diabetes mellitus?






50. Leukocyte adhesion defect presents with...







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