Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which of the hypersensitivity reactions is not Ab mediated?






2. What lymph node drains the scrotum?






3. What does Interferon alpha and beta do? how?






4. What are the autoantibodies for hashimotos?






5. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






6. other than C3a - what other complement acts as an anaphyloxin?






7. What is the toxicity of muromonab?






8. What is recomb gamma interferon used for?






9. The ______ in the BM are DN - the DP are in the cortex of thymus






10. What are the three types of lymphocytes?






11. IgE has the ___________ in the serum






12. What happens in a secondary follicle?






13. What are superantigens? give two examples.






14. The alternative pathway is the only constutively...






15. What is the marginal zone of the spleen? what happens there?






16. What is a factor that is a predictor for a bad transplantation?






17. What are the main cell surface proteins on B cells?






18. Leukocyte adhesion defect presents with...






19. What is the toxicity of azathioprine?






20. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






21. are Th cells involved in trapping of antigens of endotoxin/LPS?






22. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






23. What is the clinical use of Muromonab?






24. How does igA cross the epithelium?






25. What are the major functions of Antibodies?






26. what prevents NK cells from killing normal cells if their default is to kill?






27. Monomer in circulation - ___ when secreted






28. What are the autoantibodies for sjorgens syndrome?






29. What lymph node drains the lateral side of the dorsum of the foot?






30. How is sirolimus different from tacrolimus?






31. What does granzyme do? who secretes it?






32. What bugs can actually infect the lymph node itself?






33. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






34. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






35. can igG cross the placenta?






36. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






37. The two heavy chains of an antibody contribute to the...






38. What are the two signals to kill for NK cells?






39. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






40. What portion of the lymph node is not well developed in DiGeorge Syndrome?






41. which antibody activate mast cells - basophils - and eosinophils?






42. Which diseases are associated with DR4?






43. IgM can fix complement but...






44. What is the cause of thymic aplasia? What is its presentation? What are the labs?






45. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






46. which of the transplant rejections is antibody mediated? why does it occur?






47. What are the autoantibodies for myasthenia gravis?






48. What is colostrum?






49. How do you test for type III hypersensitivity?






50. What lymph node drains the rectum (above the pectinate line)?