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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the clinical use of Muromonab?






2. What is thrombopoietin used for?






3. Describe the capsular structure of a lymph node; What are the functions of the LN?






4. Which helper T cells' development is induced by IL 4? IL 12?






5. What are the two signals to kill for NK cells?






6. What is muromonab - CD3 (OKT3)






7. In general What are T cells good for?






8. What is the toxicity of azathioprine?






9. What is immune complex disease? give an example.






10. which B and T cell disorder presents with specifically low IgM?






11. How does igA cross the epithelium?






12. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






13. The two heavy chains of an antibody contribute to the...






14. What is recomb gamma interferon used for?






15. What lymph node drains the scrotum?






16. ________ regulate the cell mediated response.






17. What is the receptor for EBV? On what cells is that located?






18. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






19. What is the marginal zone of the spleen? what happens there?






20. What are the autoantibodies for Celiac disease?






21. Only the _______ contribute to the Fc region






22. What does granzyme do? who secretes it?






23. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






24. Give three examples of bacteria that use antigenic variation and how.






25. which of the hypersensitivity reactions is not Ab mediated?






26. Which MHC presents intracellular peptides? how so?






27. what results in symptoms of shock in an acute hemolytic transfusion reaction?






28. Which disease is associated with DR7?






29. What is recomb alpha interferon used for?






30. What does IL 10 do? who is secreted by?






31. What is the presentation of scid? treatment?






32. How do you test for chronic granulomatous disease?






33. which type of immunity is slow but long lasting? as opposed to...






34. The Fc region is found on the...






35. Type Iv hypersensitivity is...






36. So antibodies are the effectors for the humoral response. List some of their functions.






37. How do you test for type III hypersensitivity?






38. The secondary follicles have __________; primary follicles are dense






39. What does IL 4 do?






40. What is the general structure of an Ab?






41. What lymph node drains the testes?






42. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






43. What does interferon gamma do to be antiviral?






44. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






45. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






46. can igG cross the placenta?






47. How is the thymus organized? what happens in each section?






48. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






49. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






50. What are the main Cell surface proteins on T cells?