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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What lymph node drains the stomach?






2. What are the autoantibodies for sjorgens syndrome?






3. What type of fenestrations are found in the red pulp of the spleen?






4. Name 5 ways Antibody diversity is generated?






5. What lymph node drains the scrotum?






6. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






7. What is a factor that is a predictor for a bad transplantation?






8. what bacteria are a splenectomy patient most susceptible to? why?






9. What is the common variable immunodeficiency ? How is it different from Brutons?






10. What is filgrastim and sargramostim? and What is it used for?






11. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






12. when can graft versus host disease? What is the result?






13. How does complement link innate and adaptive?






14. What is recomb beta interferon used for?






15. So antibodies are the effectors for the humoral response. List some of their functions.






16. Describe complement dependent Type II hypersensitivity. Give an example.






17. The pathogenesis of contact dermatitis is ________ hypersensitivity






18. How fast does it occur?






19. Which is the most abundant antibody in blood?






20. What does IgA pick up from epithelial cells before being secreted?






21. What is the main function of interferons?






22. What are the autoantibodies for systemic sclerosis?






23. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






24. What does granulysin do?






25. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






26. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






27. What are MHC's necessary for? By themselves?






28. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






29. How does igA cross the epithelium?






30. What kinds of receptors activate innate immunity?






31. What are the autoantibodies for primary biliary cirrhosis?






32. What is passive immunity?






33. What happens in a deficiency of C3?






34. What lymph node drains the lateral side of the dorsum of the foot?






35. What is the pathogenesis of a candida skin test?






36. Which are the only two antiinflammatory cytokines?






37. Which helper T cells' development is induced by IL 4? IL 12?






38. what ensure that a memory response is generated?






39. What is the general structure of an Ab?






40. Which antibodies can be multimeric?






41. other than mediating shock - what else does TNF alpha do? who releases it mainly?






42. What is the pathology seen in chronic transplant rejection?






43. Describe the capsular structure of a lymph node; What are the functions of the LN?






44. What are the cell surface proteins on NK cells?






45. What are the PALS?






46. What do mature naive B lymphocytes express?






47. What are the main symptoms of B cell immunodeficiencies?






48. Which HLA's are included in MHC I? MHC II?

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49. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?






50. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction