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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






2. What are the autoantibodies for autoimmune hepatitis?






3. What is a type I hypersensitivity reaction? What is atopic?






4. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






5. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






6. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






7. Which disease is associated with B8?






8. How is i Th1 helper cell inhibited?






9. What lymph node drains the thigh?






10. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






11. What are the autoantibodies for primary biliary cirrhosis?






12. which cells have more complete tolerance - B or T cells?






13. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






14. What is the pathogenesis of chronic granulomatous disease; What is the presentation? What is the labs?






15. What is recomb beta interferon used for?






16. What is the clinical use for sirolimus? what should you combine it with?






17. What is the cause of thymic aplasia? What is its presentation? What are the labs?






18. What is the pathogenesis of a candida skin test?






19. what characterizes an arthus reaction?






20. What are the two signals to kill for NK cells?






21. What can cause a lymph node enlargement?






22. What lymph node drains the duodenum - jejunum?






23. What is the main cytokine released by T cells? What does it do






24. what cell surface proteins are on all APCs?






25. What are the autoantibodies for Mixed connective tissue disease?






26. How do you test for chronic granulomatous disease?






27. Name two endogenous pyrogens






28. Which disease is associated withB B27?






29. What are the PALS?






30. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






31. What lymph node drains the sigmoid colon?






32. What are the autoantibodies for systemic sclerosis?






33. hat is the presentation of Jobs syndrome or Hyper IgE?






34. To what disease do the autoantibodies to IgG (rheumatoid factor)?






35. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






36. What does IL 10 do? who is secreted by?






37. Which disease is associated with DR7?






38. What is the autoantibody for SLE that is nonspecific? Specific?






39. What is the clinical use for azathioprine?






40. How fast does it occur?






41. What are the autoantibodies for sjorgens syndrome?






42. What is a factor that is a predictor for a bad transplantation?






43. T/F B cells do not require a second signal






44. What is the defect in hyper IgM syndrome? What are the lab results?






45. which cytokine inhibits TH2 cells? secreted by who?






46. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






47. What is the pathology seen in chronic transplant rejection?






48. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






49. What are the main symptoms of T cell immunodeficiencies?






50. What are the three types of APCs?