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USMLE Step 1 Immunology

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. what cytokine does basophils secrete?

2. What type of side chains are found on Fc region of an antibody?

3. The pathogenesis of contact dermatitis is ________ hypersensitivity

4. How fast does it occur?

5. other than eat and bite RBCs what else do Macrophages of spleen do>

6. What lymph node drains the rectum (above the pectinate line)?

7. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?

8. In general What are T cells good for?

9. What is recomb beta interferon used for?

10. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?

11. What is the clinical use of Muromonab?

12. What is recomb gamma interferon used for?

13. Describe complement dependent Type II hypersensitivity. Give an example.

14. So antibodies are the effectors for the humoral response. List some of their functions.

15. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?

16. How is the thymus organized? what happens in each section?

17. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?

18. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?

19. which antibody is involved in the primary response or immediate response to an antigen?

20. What is three common causes of severe combined immunodef? What is the result of all three?

21. What is muromonab - CD3 (OKT3)

22. what bacteria are a splenectomy patient most susceptible to? why?

23. What is oprelevkin? and What is it used for?

24. What is the arthus reaction? What is the difference between arthus and serum sickness? give an example. How do you test for it?

25. What does Interferon alpha and beta do? how?

26. What are the symptoms of serum sickness?

27. What is the main function of interferons?

28. What does IL 5 do?

29. The alternative pathway is the only constutively...

30. What is the pathology in hyperacute transplant rejection?

31. Describe the Mannose Lectin pathway

32. Name 5 ways Antibody diversity is generated?

33. How does complement link innate and adaptive?

34. which of the transplant rejections is antibody mediated? why does it occur?

35. What cytokines do macrophages release? who else can secrete IL 6? IL 12?

36. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?

37. what characterizes an arthus reaction?

38. __________ are a part of the innate system.

39. What is chronic mucocutaneous candidiasis d/t?

40. What does interferon gamma do? What two type of cells does it attack mostly?

41. describe the pathogenesis of delayed type IV hypersensitivity

42. Which diseases are associated with DR5?

43. How is i Th1 helper cell inhibited?

44. What portion of the lymph node is not well developed in DiGeorge Syndrome?

45. What is a type I hypersensitivity reaction? What is atopic?

46. What does interferon gamma do to be antiviral?

47. What is the mechanism for sirolimus? what else it known as?

48. What are the cell surface proteins for Macrophages? which two are for opsonins?

49. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?

50. what cell surface proteins are on all APCs?