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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






2. What is a type I hypersensitivity reaction? What is atopic?






3. What are the autoantibodies for hashimotos?






4. What is the main function of interferons?






5. What is the pathogenesis of acute transplant rejection? When does it occur?






6. __________ are a part of the innate system.






7. give an example of how influenza does a major antigenic shift.






8. What is the autoantibody for SLE that is nonspecific? Specific?






9. Type IV hypersensitivity is i...






10. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






11. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






12. after C3 spontaneously hydrolyzes to C3b and C3a - what happens to C3a?






13. What is recomb gamma interferon used for?






14. What lymph node drains the thigh?






15. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






16. What does interferon gamma do to be antiviral?






17. Which cytokines do Th2 release and For what?






18. What is the main cytokine released by T cells? What does it do






19. What do mature naive B lymphocytes express?






20. Which helper T cells' development is induced by IL 4? IL 12?






21. What are the autoantibodies for myasthenia gravis?






22. What is the common variable immunodeficiency ? How is it different from Brutons?






23. What are the autoantibodies for type I diabetes mellitus?






24. other than C3a - what other complement acts as an anaphyloxin?






25. Only the _______ contribute to the Fc region






26. Which disease is associated with HLA A3?






27. can igG cross the placenta?






28. Name two endogenous pyrogens






29. What is anergy? why does this occur?






30. What are the mediators that mast cells release?






31. What is the main function of TNF alpha? How does it do this?






32. What are the autoantibodies for pernicious anemia?






33. What is the toxicity of azathioprine?






34. Which diseases are associated with DR4?






35. What is the presentation of hyperIgM syndrome?






36. What is the late phase reaction of anaphylaxis allergy? what mediates it?






37. In thymic development - What is the positive selection? negative selections?






38. What does it mean if there are igM in the serum at birth?






39. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






40. Which HLA's are included in MHC I? MHC II?

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41. What are the cell surface proteins on NK cells?






42. Which are the only two antiinflammatory cytokines?






43. What is muromonab - CD3 (OKT3)






44. what cell surface proteins are on all APCs?






45. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






46. ________ regulate the cell mediated response.






47. What is the clinical use for sirolimus? what should you combine it with?






48. which B and T cell disorder presents with specifically low IgM?






49. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






50. How fast does it occur?