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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the main function of TNF alpha? How does it do this?






2. Name 5 ways Antibody diversity is generated?






3. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






4. In general What are T cells good for?






5. What are the two signals required for Th1 cells? what happens after then activated?






6. What is the receptor for EBV? On what cells is that located?






7. In thymic development - What is the positive selection? negative selections?






8. What are the labs in brutons agammaglobulinemia?






9. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






10. What is recomb alpha interferon used for?






11. How is sirolimus different from tacrolimus?






12. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






13. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






14. Which diseases are associated with DR4?






15. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






16. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






17. What is the most common selective Ig deficiency? What is the presentation?






18. What is the late phase reaction of anaphylaxis allergy? what mediates it?






19. What bugs can actually infect the lymph node itself?






20. The pathogenesis of contact dermatitis is ________ hypersensitivity






21. What are the three types of APCs?






22. What lymph node drains the testes?






23. What does granulysin do?






24. The alternative pathway is the only constutively...






25. What are the two signals required for T cells? what happens after?






26. What is the main function of interferons?






27. What does IL 4 do?






28. what will NK cells do to cells covered in IgG Ab? why?






29. The MALT/GALT are not...






30. What is the presentation of common variable immunodef? and What are the labs?






31. What is the defect in hyper IgM syndrome? What are the lab results?






32. What lymph node drains the upper limb?






33. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






34. What are the autoantibodies for polymyositis and dermatomyositis?






35. What do multimeric antibodies require for assembly?






36. other than eat and bite RBCs what else do Macrophages of spleen do>






37. What are the autoantibodies for drug induced lupus?






38. To what disease do the autoantibodies to IgG (rheumatoid factor)?






39. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






40. What lymph node drains the duodenum - jejunum?






41. What are the autoantibodies for Celiac disease?






42. what happens in a deficiency of C1 esterase inhibitor? DAF?






43. What are the autoantibodies for systemic sclerosis?






44. Which disease is associated withB B27?






45. What are the autoantibodies for autoimmune hepatitis?






46. Which disease is associated with HLA A3?






47. What are the cell surface proteins for Macrophages? which two are for opsonins?






48. Which is the main antibody in the delayed or secondary response to an antigen?






49. What is the most common example of passive immunity?






50. What are the main Cell surface proteins on T cells?