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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






2. Describe the capsular structure of a lymph node; What are the functions of the LN?






3. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






4. What is the main function of interferons?






5. What is the presentation of hyperIgM syndrome?






6. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






7. What is the presentation of Brutons agammaglobulinemia?






8. What type of side chains are found on Fc region of an antibody?






9. A lymph node is a ________ lymphoid organ.






10. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






11. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






12. other than mediating shock - what else does TNF alpha do? who releases it mainly?






13. Name 5 ways Antibody diversity is generated?






14. Which antibodies can be multimeric?






15. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






16. What are four results of a splenectomy?






17. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






18. What are the autoantibodies for goodpastures syndrome?






19. What lymph node drains the breast?






20. What is the common variable immunodeficiency ? How is it different from Brutons?






21. is IgM an opsonizer?






22. What lymph node drains the upper limb?






23. What cytokines to Th2 secrete?






24. How do you test for chronic granulomatous disease?






25. What is the presentation of common variable immunodef? and What are the labs?






26. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






27. What is the main function of TNF alpha? How does it do this?






28. Which disease is associated withB B27?






29. where are complements produced?






30. Describe the Mannose Lectin pathway






31. What are the mediators that mast cells release?






32. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






33. Which is the main antibody that provides passive immunity to infants?






34. What is the late phase reaction of anaphylaxis allergy? what mediates it?






35. Which MHC presents intracellular peptides? how so?






36. which antibody is involved in the primary response or immediate response to an antigen?






37. How does complement link innate and adaptive?






38. What lymph node drains the stomach?






39. What are the symptoms of serum sickness?






40. What are some sinopulmonary infections?






41. Leukocyte adhesion defect presents with...






42. How is i Th1 helper cell inhibited?






43. Which diseases are associated with DR4?






44. what characterizes an arthus reaction?






45. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






46. What are the autoantibodies for Celiac disease?






47. Which disease is associated with DR7?






48. What is the pathogenesis of a candida skin test?






49. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






50. What is filgrastim and sargramostim? and What is it used for?