Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which is the main antibody that provides passive immunity to infants?






2. Give three examples of bacteria that use antigenic variation and how.






3. What is filgrastim and sargramostim? and What is it used for?






4. What is the most common example of passive immunity?






5. A lymph node is a ________ lymphoid organ.






6. To what portion of the Antibody do the complements bind?






7. The two heavy chains of an antibody contribute to the...






8. can igG cross the placenta?






9. What is the late phase reaction of anaphylaxis allergy? what mediates it?






10. Which are the only two antiinflammatory cytokines?






11. What is chronic mucocutaneous candidiasis d/t?






12. For which toxins are preformed antibodies (passive) given?






13. What is the general structure of an Ab?






14. Which MHC presents intracellular peptides? how so?






15. describe the classic complement pathway.






16. From where do cytokines come from?






17. What are the autoantibodies for polymyositis and dermatomyositis?






18. What do mature naive B lymphocytes express?






19. What are the autoantibodies for autoimmune hepatitis?






20. What lymph node drains the lateral side of the dorsum of the foot?






21. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






22. Describe the Mannose Lectin pathway






23. What does IL 2 do?






24. What are the symptoms of serum sickness?






25. How is the thymus organized? what happens in each section?






26. What are the two signals required for Th1 cells? what happens after then activated?






27. What does granzyme do? who secretes it?






28. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






29. which of the transplant rejections is antibody mediated? why does it occur?






30. What lymph node drains the thigh?






31. What is the white pulp of the spleen?






32. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






33. How is i Th1 helper cell inhibited?






34. __________ are a part of the innate system.






35. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






36. which antibody activate mast cells - basophils - and eosinophils?






37. Which disease is associated with HLA A3?






38. What type of side chains are found on Fc region of an antibody?






39. What is the autoantibody for SLE that is nonspecific? Specific?






40. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






41. Leukocyte adhesion defect presents with...






42. What are the two signals required for B cell class switching? Which is the second signal?






43. IgE has the ___________ in the serum






44. What is serum sickness? give an example.






45. What is passive immunity?






46. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






47. How does complement link innate and adaptive?






48. what secretes IL 4?






49. What is the common variable immunodeficiency ? How is it different from Brutons?






50. Which type of selection of thymic development provides central tolerance?