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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






2. What are the autoantibodies for myasthenia gravis?






3. What is the pathogenesis of a hypersensitivity reaction?






4. IgE has the ___________ in the serum






5. The two heavy chains of an antibody contribute to the...






6. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






7. what secretes IL 4?






8. Which antibodies can be multimeric?






9. What is the main function of interferons?






10. Which is the main antibody that provides passive immunity to infants?






11. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






12. What does granulysin do?






13. Describe the capsular structure of a lymph node; What are the functions of the LN?






14. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






15. What are the T cell functions?






16. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






17. What is colostrum?






18. So antibodies are the effectors for the humoral response. List some of their functions.






19. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






20. What is thrombopoietin used for?






21. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






22. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






23. What is the common variable immunodeficiency ? How is it different from Brutons?






24. Which disease is associated with B8?






25. What is the toxicity of muromonab?






26. What does interferon gamma do? What two type of cells does it attack mostly?






27. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






28. In thymic development - What is the positive selection? negative selections?






29. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






30. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






31. what results in symptoms of shock in an acute hemolytic transfusion reaction?






32. What cytokines are released by Th1 cells?






33. hat is the presentation of Jobs syndrome or Hyper IgE?






34. What are the autoantibodies for type I diabetes mellitus?






35. in which immunodef order do you see a lot of pus? no pus?






36. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






37. What lymph node drains the sigmoid colon?






38. what cell surface marker is used for NK cells as it is unique to them?






39. Give an example of someone who could get hyperacute transplant rejection.






40. What are the mediators that mast cells release?






41. What are the three types of lymphocytes?






42. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






43. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






44. What is recomb gamma interferon used for?






45. What are some catalase positive organisms?






46. What is the mechanism for sirolimus? what else it known as?






47. Which disease is associated with DR7?






48. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






49. What can cause a lymph node enlargement?






50. What are the cell surface proteins on NK cells?