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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






2. What does IL 10 do? who is secreted by?






3. What is recomb beta interferon used for?






4. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






5. Type Iv hypersensitivity is...






6. What is the treatment of acute transplant rejection?






7. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






8. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






9. What is three common causes of severe combined immunodef? What is the result of all three?






10. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






11. To what portion of the Antibody do the complements bind?






12. What two ways do you test for a type 1 hypersensitivity reaction? what will you see?






13. What are the autoantibodies for systemic sclerosis?






14. Which disease is associated with DR3?






15. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






16. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






17. ________ regulate the cell mediated response.






18. What does IL 5 do?






19. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






20. What can cause a lymph node enlargement?






21. What is the pathogenesis of HyperIgE syndrome? What are the labs?






22. What are the autoantibodies for graves?






23. IgM can exist as a _______ also






24. What does IgA pick up from epithelial cells before being secreted?






25. What is digoxin immune Fab used for?






26. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






27. Describe the complement independent Type II hypersenstivity reaction. Give an example.






28. what will NK cells do to cells covered in IgG Ab? why?






29. In thymic development - What is the positive selection? negative selections?






30. How is the thymus organized? what happens in each section?






31. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






32. How is the antigen loaded onto a MHC II?






33. What is the clinical use of Muromonab?






34. What are the autoantibodies for drug induced lupus?






35. What is the mechanism for sirolimus? what else it known as?






36. What are the autoantibodies for type I diabetes mellitus?






37. What lymph node drains the lateral side of the dorsum of the foot?






38. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






39. The alternative pathway is the only constutively...






40. What is chronic mucocutaneous candidiasis d/t?






41. which interleukin receptor is required for NK development? activation?






42. which B and T cell disorder presents with specifically low IgM?






43. Give an example of someone who could get hyperacute transplant rejection.






44. What lymph node drains the breast?






45. What lymph node drains the thigh?






46. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






47. What are C1 - C2 - C3 - C4 important for?






48. What are the autoantibodies for primary biliary cirrhosis?






49. which of the hypersensitivity reactions is not Ab mediated?






50. What are the autoantibodies for hashimotos?







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