Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How fast does it occur?






2. Which disease is associated with HLA A3?






3. A lymph node is a ________ lymphoid organ.






4. Which disease is associated with B8?






5. What lymph node drains the upper limb?






6. what secretes IL 4?






7. The lymphocytes are ________ origin






8. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






9. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






10. hat is the presentation of Jobs syndrome or Hyper IgE?






11. What is an example of a parasite showing antigenic variation?






12. What can cause a lymph node enlargement?






13. What is the pathology seen in chronic transplant rejection?






14. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






15. What is muromonab - CD3 (OKT3)






16. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






17. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






18. What are C1 - C2 - C3 - C4 important for?






19. where do somatic hypermutation and class switching occur?






20. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






21. The Fc region is found on the...






22. What are the three types of APCs?






23. What are the autoantibodies for primary biliary cirrhosis?






24. What are the autoantibodies for Mixed connective tissue disease?






25. What are the labs in brutons agammaglobulinemia?






26. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






27. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






28. What is the pathogenesis of a candida skin test?






29. What is thrombopoietin used for?






30. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






31. What is the presentation of hyperIgM syndrome?






32. What are the autoantibodies for hashimotos?






33. The two heavy chains of an antibody contribute to the...






34. What does it mean if there are igM in the serum at birth?






35. In thymic development - What is the positive selection? negative selections?






36. What are howell jolly bodies?






37. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






38. which type of immunity is slow but long lasting? as opposed to...






39. Which is the most abundant antibody in blood?






40. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






41. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






42. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






43. What are the two signals required for Th1 cells? what happens after then activated?






44. other than mediating shock - what else does TNF alpha do? who releases it mainly?






45. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






46. can igG cross the placenta?






47. What is the treatment of acute transplant rejection?






48. What are the two signals required for B cell class switching? Which is the second signal?






49. which antibody activate mast cells - basophils - and eosinophils?






50. What does Interferon alpha and beta do? how?