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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






2. which antibodies prevent antigens from binding mucosal surfaces?






3. What are the function of B cells?






4. ________ regulate the cell mediated response.






5. Which disease is associated with DR7?






6. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






7. What is the pathology of acute transplant rejection? is it reversible?






8. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






9. Describe the capsular structure of a lymph node; What are the functions of the LN?






10. What is thrombopoietin used for?






11. Which disease is associated with HLA A3?






12. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






13. what cell surface marker is used for NK cells as it is unique to them?






14. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






15. What is the general structure of an Ab?






16. What is the presentation of Brutons agammaglobulinemia?






17. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






18. which cytokine inhibits TH2 cells? secreted by who?






19. For which toxins are preformed antibodies (passive) given?






20. Describe complement dependent Type II hypersensitivity. Give an example.






21. Which TCR MHC system is important for viral immunity? neoplastic? donor graft cells?






22. The idiotype; the Fc portion determines the...






23. What are the T cell functions?






24. Which type of selection of thymic development provides central tolerance?






25. Which disease is associated with B8?






26. describe the pathogenesis of delayed type IV hypersensitivity






27. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






28. What is the pathogenesis of IgG AIHA ABO hemolytic disease of a newborn? describe what happens.






29. The lymphocytes are ________ origin






30. what will NK cells do to cells covered in IgG Ab? why?






31. What is the late phase reaction of anaphylaxis allergy? what mediates it?






32. What type of fenestrations are found in the red pulp of the spleen?






33. What are the four steps in phagocytosis? What are the four disease that correspond to each step?






34. What is the presentation of scid? treatment?






35. What lymph node drains the scrotum?






36. what mediates the type II hypersensitivity? What are the two different methods?






37. How do you test for type III hypersensitivity?






38. give an example of how influenza does a major antigenic shift.






39. Name the three opsonins






40. which B and T cell disorder presents with specifically low IgM?






41. What is colostrum?






42. What are the cell surface proteins for Macrophages? which two are for opsonins?






43. What does IgE do on the surface of the mast cell to induce inflammatory mediator release?






44. where are complements produced?






45. A lymph node is a ________ lymphoid organ.






46. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






47. what results in symptoms of shock in an acute hemolytic transfusion reaction?






48. What are the mediators that mast cells release?






49. To what portion of the Antibody do the complements bind?






50. Which disease is associated with DR3?