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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do you test for type III hypersensitivity?






2. What does interferon gamma do to be antiviral?






3. what else does interferon gamma do other than inducing ribonuclease production - activating NK cells - inducing increased MHC expression?






4. How do we use thymus dependent antigens to prevent infection from organisms that lack a peptide component?






5. What are the main Cell surface proteins on T cells?






6. What are the autoantibodies for pernicious anemia?






7. What is colostrum?






8. What is the clinical use for azathioprine?






9. What is the clinical use of Muromonab?






10. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






11. What are the autoantibodies for primary biliary cirrhosis?






12. What lymph node drains the upper limb?






13. What is the pathogenesis of acute transplant rejection? When does it occur?






14. IgG...






15. Which is the most abundant antibody in blood?






16. Which type of selection of thymic development provides central tolerance?






17. What lymph node drains the rectum (above the pectinate line)?






18. What is Aldesleukin? What is it used for






19. Name two endogenous pyrogens






20. How does complement link innate and adaptive?






21. How is the antigen loaded onto a MHC II?






22. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






23. What are the main cell surface proteins on B cells?






24. other than mediating shock - what else does TNF alpha do? who releases it mainly?






25. Which is the main antibody that provides passive immunity to infants?






26. What are the main symptoms of T cell immunodeficiencies?






27. What does granulysin do?






28. What is the marginal zone of the spleen? what happens there?






29. what mediates the type II hypersensitivity? What are the two different methods?






30. Which cytokines do Th2 release and For what?






31. What does IL 2 do?






32. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






33. The alternative pathway is the only constutively...






34. Which helper T cells' development is induced by IL 4? IL 12?






35. So antibodies are the effectors for the humoral response. List some of their functions.






36. What lymph node drains the sigmoid colon?






37. What are the autoantibodies for polymyositis and dermatomyositis?






38. What are the three types of lymphocytes?






39. What are the two signals required for B cell class switching? Which is the second signal?






40. where do somatic hypermutation and class switching occur?






41. How fast does it occur?






42. which antibodies can bind complement?






43. What is the presentation of common variable immunodef? and What are the labs?






44. What are MHC Class molecules (ie what macromolecule are they made out of)? what gene are responsible for MHC?






45. What are the three types of APCs?






46. what secretes IL 4?






47. What are the two signals required for T cells? what happens after?






48. Describe complement dependent Type II hypersensitivity. Give an example.






49. What lymph node drains the breast?






50. What are the autoantibodies for other vasculitides?







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