Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which of the transplant rejections is antibody mediated? why does it occur?






2. What is the most common example of passive immunity?






3. What lymph node drains the upper limb?






4. What cytokines to Th2 secrete?






5. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






6. What does granzyme do? who secretes it?






7. Which cytokines do Th2 release and For what?






8. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






9. How do you test for type III hypersensitivity?






10. which cells have more complete tolerance - B or T cells?






11. What lymph node drains the testes?






12. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






13. The MALT/GALT are not...






14. What are some catalase positive organisms?






15. What happens in a secondary follicle?






16. The Fc region is found on the...






17. What is the toxicity of azathioprine?






18. which type of immunity is slow but long lasting? as opposed to...






19. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






20. Which helper T cells' development is induced by IL 4? IL 12?






21. which antibody is involved in the primary response or immediate response to an antigen?






22. What lymph node drains the breast?






23. IgM can fix complement but...






24. What does granulysin do?






25. What are C1 - C2 - C3 - C4 important for?






26. What is the defect in hyper IgM syndrome? What are the lab results?






27. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






28. A lymph node is a ________ lymphoid organ.






29. What are the major functions of Antibodies?






30. What does IgA pick up from epithelial cells before being secreted?






31. What bugs can actually infect the lymph node itself?






32. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






33. give an example of how influenza does a major antigenic shift.






34. What is three common causes of severe combined immunodef? What is the result of all three?






35. Name 5 ways Antibody diversity is generated?






36. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






37. The two heavy chains of an antibody contribute to the...






38. What links the adaptive and innate immunity?






39. What does IL 4 do?






40. What happens in a deficiency of C3?






41. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






42. What are the autoantibodies for polymyositis and dermatomyositis?






43. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?






44. What are the autoantibodies for Mixed connective tissue disease?






45. what results in symptoms of shock in an acute hemolytic transfusion reaction?






46. What are superantigens? give two examples.






47. What are the autoantibodies for pernicious anemia?






48. What are the main symptoms of B cell immunodeficiencies?






49. What are the autoantibodies for Celiac disease?






50. Describe the capsular structure of a lymph node; What are the functions of the LN?