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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. which antibody activate mast cells - basophils - and eosinophils?






2. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






3. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






4. What is immune complex disease? give an example.






5. Which HLA's are included in MHC I? MHC II?

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6. other than mediating shock - what else does TNF alpha do? who releases it mainly?






7. What are the autoantibodies for Celiac disease?






8. What is the cause of thymic aplasia? What is its presentation? What are the labs?






9. __________ are a part of the innate system.






10. What type of side chains are found on Fc region of an antibody?






11. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






12. describe the pathogenesis of delayed type IV hypersensitivity






13. What is MHC I made out of? Where is it found? What does it bind to? What type of antigens does it present?






14. What type of fenestrations are found in the red pulp of the spleen?






15. What are the autoantibodies for myasthenia gravis?






16. What is epo used for?






17. What is an autograft? syngeneic graft? allograft? xenograft? What is an ex of an allograft? xenograft?






18. Which disease is associated withB B27?






19. What does IL 10 do? who is secreted by?






20. What is the pathogenesis of a candida skin test?






21. What bugs can actually infect the lymph node itself?






22. What is the presentation of Brutons agammaglobulinemia?






23. How does the alternative pathway lead to MAC activation?






24. What portion of the lymph node is not well developed in DiGeorge Syndrome?






25. hat is the presentation of Jobs syndrome or Hyper IgE?






26. Which diseases are associated with DR4?






27. Which antibody mediates immunity to worms? how?






28. in which immunodef order do you see a lot of pus? no pus?






29. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






30. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






31. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






32. What is the pathology of acute transplant rejection? is it reversible?






33. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






34. The ______ in the BM are DN - the DP are in the cortex of thymus






35. The pathogenesis of contact dermatitis is ________ hypersensitivity






36. What lymph node drains the anal canal (below the pectinate line)?






37. What are the symptoms of serum sickness?






38. what ensure that a memory response is generated?






39. From where do cytokines come from?






40. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






41. What are the T cell functions?






42. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?






43. What is the late phase reaction of anaphylaxis allergy? what mediates it?






44. Which cytokines do Th2 release and For what?






45. Which is the main antibody that provides passive immunity to infants?






46. What lymph node drains the sigmoid colon?






47. What are the autoantibodies for drug induced lupus?






48. What are the autoantibodies for goodpastures syndrome?






49. where are complements produced?






50. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






Can you answer 50 questions in 15 minutes?



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