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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is a type I hypersensitivity reaction? What is atopic?






2. describe the classic complement pathway.






3. Other than stimulating fever - what else does IL 6 do?






4. What are the autoantibodies for pernicious anemia?






5. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






6. What is immune complex disease? give an example.






7. What is the pathology in hyperacute transplant rejection?






8. what ensure that a memory response is generated?






9. What is the late phase reaction of anaphylaxis allergy? what mediates it?






10. Which disease is associated with DR3?






11. What is the pathology of acute transplant rejection? is it reversible?






12. __________ are a part of the innate system.






13. What are the symptoms of serum sickness?






14. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






15. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






16. What does CD16 on NK cells do?






17. What are the main symptoms of B cell immunodeficiencies?






18. What are the two signals to kill for NK cells?






19. What is the toxicity of muromonab?






20. what cytokine does basophils secrete?






21. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






22. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






23. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






24. Which diseases are associated with DR2?






25. Which disease is associated with DR7?






26. Type Iv hypersensitivity is...






27. What are the autoantibodies for Mixed connective tissue disease?






28. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






29. What does IL 4 do?






30. T/F B cells do not require a second signal






31. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






32. What is colostrum?






33. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






34. What is the main function of IL 8?






35. can igG cross the placenta?






36. What are the three types of APCs?






37. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






38. The Fc region is found on the...






39. For which toxins are preformed antibodies (passive) given?






40. What is chronic mucocutaneous candidiasis d/t?






41. What are the two signals required for Th1 cells? what happens after then activated?






42. What are C1 - C2 - C3 - C4 important for?






43. ________ regulate the cell mediated response.






44. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






45. If an antigen lacks a peptide component How does the adaptive immunity attack it? What type of response is this called. give an example of bugs that do this. what implications does this have on splenectomy?






46. What is the main function of interferons?






47. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






48. what results in symptoms of shock in an acute hemolytic transfusion reaction?






49. The alternative pathway is the only constutively...






50. Which antibody mediates immunity to worms? how?