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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What does Interferon alpha and beta do? how?






2. What are the major functions of Antibodies?






3. What is MHC II made out of? Where is it found? What does it bind to? What type of antigens does it present?






4. How does the alternative pathway lead to MAC activation?






5. The pathogenesis of contact dermatitis is ________ hypersensitivity






6. How is sirolimus different from tacrolimus?






7. IgE has the ___________ in the serum






8. ________ regulate the cell mediated response.






9. For which toxins are preformed antibodies (passive) given?






10. What does CD16 on NK cells do?






11. Describe complement dependent Type II hypersensitivity. Give an example.






12. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






13. What are the three types of lymphocytes?






14. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






15. What is the general structure of an Ab?






16. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






17. What is Aldesleukin? What is it used for






18. What is the white pulp of the spleen?






19. What is the marginal zone of the spleen? what happens there?






20. What are the autoantibodies for graves?






21. What type of fenestrations are found in the red pulp of the spleen?






22. What do macrophages secrete that activate Th1 cells to secrete interferon gamma?






23. What are the autoantibodies for other vasculitides?






24. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






25. What are the T cell functions?






26. What is the defect in Leukocyte adhesion defect? What is the presentation? What are the labs?






27. What is wiskott aldrich syndrome? What is its mode of inheritance? What is the pathogenesis of disease? What is its triad of presentation? what labs does it present with?






28. hat is the presentation of Jobs syndrome or Hyper IgE?






29. What are the sinusoids of the spleen? What is the difference between a spleen and a lymph node?






30. where do somatic hypermutation and class switching occur?






31. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






32. What lymph node drains the upper limb?






33. To what portion of the Antibody do the complements bind?






34. What are the autoantibodies for scleroderma (CREST)? scleroderma diffuse?






35. Which are the only two antiinflammatory cytokines?






36. Describe the Mannose Lectin pathway






37. What is the presentation of hyperIgM syndrome?






38. What lymph node drains the duodenum - jejunum?






39. What is the presentation of common variable immunodef? and What are the labs?






40. What is the result of an IL 12 deficiency? What is the presentation? What are the labs?






41. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






42. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






43. What are the PALS?






44. What are four results of a splenectomy?






45. Monomer in circulation - ___ when secreted






46. In general What are T cells good for?






47. Give an example of someone who could get hyperacute transplant rejection.






48. What is the symptoms involved in graft versus host disease? it What transplant cases does it usually occur? give an example






49. What are the autoantibodies for sjorgens syndrome?






50. where are complements produced?







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