Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. IgM can fix complement but...






2. What lymph node drains the rectum (above the pectinate line)?






3. which of the hypersensitivity reactions is not Ab mediated?






4. Which disease is associated withB B27?






5. What are C1 - C2 - C3 - C4 important for?






6. Leukocyte adhesion defect presents with...






7. which antibody activate mast cells - basophils - and eosinophils?






8. What are the main symptoms of B cell immunodeficiencies?






9. What are the mediators that mast cells release?






10. Which is the most abundant antibody in blood?






11. What are the T cell functions?






12. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






13. What does IgA pick up from epithelial cells before being secreted?






14. give an example of how influenza does a major antigenic shift.






15. What is the end result of complement activation? what bugs are this important for? through what pathway and why?






16. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






17. What is the white pulp of the spleen?






18. What is a type I hypersensitivity reaction? What is atopic?






19. What is anergy? why does this occur?






20. What lymph node drains the breast?






21. What are the autoantibodies for pemphigus bulgaris?






22. How does complement link innate and adaptive?






23. What is the most common example of passive immunity?






24. What is oprelevkin? and What is it used for?






25. How do you test for type III hypersensitivity?






26. What is a factor that is a predictor for a bad transplantation?






27. What are the three immune privileged sites? why are they called that? what happens after infection in these areas?






28. What is the mode of inheritance of Chediak Higashi syndrome? What is the disease d/t? What does it result in? What is the presentation?






29. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






30. Give an example of someone who could get hyperacute transplant rejection.






31. Which is the main antibody that provides passive immunity to infants?






32. So antibodies are the effectors for the humoral response. List some of their functions.






33. what happens in a deficiency of C1 esterase inhibitor? DAF?






34. What lymph node drains the upper limb?






35. Which is the main antibody in the delayed or secondary response to an antigen?






36. What are the autoantibodies for myasthenia gravis?






37. Complements are...






38. which cytokine inhibits TH2 cells? secreted by who?






39. What are the two signals to kill for NK cells?






40. How is the thymus organized? what happens in each section?






41. which interleukin receptor is required for NK development? activation?






42. How is i Th1 helper cell inhibited?






43. What is the main function of TNF alpha? How does it do this?






44. What are the autoantibodies for graves?






45. is IgM an opsonizer?






46. Which antibody mediates immunity to worms? how?






47. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






48. Which MHC presents intracellular peptides? how so?






49. what mediates the type II hypersensitivity? What are the two different methods?






50. describe the pathogenesis of delayed type IV hypersensitivity