Test your basic knowledge |

USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do you test for chronic granulomatous disease?






2. What does Interferon alpha and beta do? how?






3. What bugs can actually infect the lymph node itself?






4. What is the late phase reaction of anaphylaxis allergy? what mediates it?






5. What is the presentation of scid? treatment?






6. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






7. IgE has the ___________ in the serum






8. which of the transplant rejections is antibody mediated? why does it occur?






9. What is a factor that is a predictor for a bad transplantation?






10. Often bacteria are associated with being killed by humoral immunity. Name some bugs that require cell mediated immunity because they evade humoral response






11. Leukocyte adhesion defect presents with...






12. What is the presentation of common variable immunodef? and What are the labs?






13. which cytokine inhibits TH2 cells? secreted by who?






14. what happens in a deficiency of C1 esterase inhibitor? DAF?






15. The lymphocytes are ________ origin






16. What are the autoantibodies for polymyositis and dermatomyositis?






17. Describe the Mannose Lectin pathway






18. What are the PALS?






19. Which disease is associated with B8?






20. What is the toxicity of muromonab?






21. what characterizes an arthus reaction?






22. How does igA cross the epithelium?






23. What are the autoantibodies for graves?






24. The alternative pathway is the only constutively...






25. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






26. What is recomb beta interferon used for?






27. What is ataxia telangectasia? What is it caused by? What is the triad of presentation? and its labs?






28. What are the autoantibodies for Mixed connective tissue disease?






29. What is recomb alpha interferon used for?






30. What cytokines are released by Th1 cells?






31. What does IL 2 do?






32. What lymph node drains the thigh?






33. What are the autoantibodies for goodpastures syndrome?






34. In thymic development - What is the positive selection? negative selections?






35. What is anergy? why does this occur?






36. What amine is the main chemical mediator released by mast cells? Where does it act What does it result in?






37. Describe complement dependent Type II hypersensitivity. Give an example.






38. What are the autoantibodies for pernicious anemia?






39. What is the autoantibody for SLE that is nonspecific? Specific?






40. with failed maturation of B cells in Brutons agammaglobulinemia - What is its effect on immune pathways and why?






41. How do endotoxin/LPS of gram negative bacteria stimulate the immune system if they do not have a peptide fragment?






42. Which disease is associated with DR3?






43. DTH (delayed type hypersensitivity) is the ________ of a PPD reaction






44. What is the clinical use of Muromonab?






45. What are howell jolly bodies?






46. To what portion of the Antibody do the complements bind?






47. What is the clinical use for azathioprine?






48. Which MHC presents intracellular peptides? how so?






49. What kinds of receptors activate innate immunity?






50. In general What are T cells good for?