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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the pathology of acute transplant rejection? is it reversible?






2. what happens in a deficiency of C5- C8? why dont you get recurrent pyogenic infections like in C3 def?






3. What is the thymus ? Where is it located? is it encapsulated? How many lobes does it have?






4. Which diseases are associated with DR5?






5. What is oprelevkin? and What is it used for?






6. describe the classic complement pathway.






7. What are the autoantibodies for wegeners granulomatosis?






8. What is the pathogenesis of HyperIgE syndrome? What are the labs?






9. How is i Th1 helper cell inhibited?






10. Other than stimulating fever - what else does IL 6 do?






11. Describe the Mannose Lectin pathway






12. other than eat and bite RBCs what else do Macrophages of spleen do>






13. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?






14. In thymic development - What is the positive selection? negative selections?






15. What are howell jolly bodies?






16. explain the process from beginning (ie phagocytosis of the peptide) to end of how Abs are formed in Goodpasteurs.






17. other than C3a - what other complement acts as an anaphyloxin?






18. Describe complement dependent Type II hypersensitivity. Give an example.






19. What cytokines to Th2 secrete?






20. A lymph node is a ________ lymphoid organ.






21. which antibodies prevent antigens from binding mucosal surfaces?






22. What are the main Cell surface proteins on T cells?






23. which of the IL2 inhibitors produce nephrotoxicity? thrombocytopenia/leukopenia?






24. What happens in a deficiency of C3?






25. What is the common variable immunodeficiency ? How is it different from Brutons?






26. What is the toxicity of azathioprine?






27. What does Interferon alpha and beta do? how?






28. which immunodeficiency presents with delayed separation of the umbilicus? ataxia? telangiectasia?albinism? anaphylaxis on exposure to blood products with IgA? tetany?retained primary teeth? peripheral neuropathy?






29. What are the mediators that mast cells release?






30. What are the autoantibodies for primary biliary cirrhosis?






31. What are HEV? Where are they found? Where does the vasculature of the lymph node travel to?






32. What does IgA pick up from epithelial cells before being secreted?






33. To what disease do the autoantibodies to IgG (rheumatoid factor)?






34. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?






35. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






36. ________ regulate the cell mediated response.






37. How fast does it occur?






38. describe the pathogenesis of delayed type IV hypersensitivity






39. What is serum sickness? give an example.






40. What are the autoantibodies for Mixed connective tissue disease?






41. What is the most common selective Ig deficiency? What is the presentation?






42. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






43. What is the clinical use of Muromonab?






44. What are superantigens? give two examples.






45. Type IV hypersensitivity is i...






46. What is the pathology in hyperacute transplant rejection?






47. Describe the capsular structure of a lymph node; What are the functions of the LN?






48. What is the pathogenesis of a hypersensitivity reaction?






49. What are the autoantibodies for autoimmune hepatitis?






50. which cytokine inhibits TH2 cells? secreted by who?







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