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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the autoantibodies for pernicious anemia?






2. Complements are...






3. what cell surface marker is used for NK cells as it is unique to them?






4. So antibodies are the effectors for the humoral response. List some of their functions.






5. What part of the complement system also acts as an opsonin? What is opsonization? can you Name two other opsonins?






6. What is the monoclonal antibody to IL2 on activated T cells? What is it used for?






7. What is the pathogenesis of a candida skin test?






8. Only the _______ contribute to the Fc region






9. What is chronic mucocutaneous candidiasis d/t?






10. what cell surface proteins are on all APCs?






11. What is the pathology of acute transplant rejection? is it reversible?






12. Which MHC presents intracellular peptides? how so?






13. What lymph node drains the rectum (above the pectinate line)?






14. What is the clinical use for sirolimus? what should you combine it with?






15. What is the main function of interferons?






16. What is the pathology seen in chronic transplant rejection?






17. What is the main function of IL 8?






18. are Th cells involved in trapping of antigens of endotoxin/LPS?






19. in which immunodef order do you see a lot of pus? no pus?






20. What are the mediators that mast cells release?






21. The alternative pathway is the only constutively...






22. where do NK cells develop?






23. What is the difference of IgE AIHA and IgG AIHA if they are both complement dependent type II hypersensitivities?






24. How is the thymus organized? what happens in each section?






25. What do mature naive B lymphocytes express?






26. Which Thelper cell activated Macrophages? by secreting what? what else does Th1 secrete? For what?






27. What are the autoantibodies for systemic sclerosis?






28. which antibodies can bind complement?






29. To what portion of the Antibody do the complements bind?






30. can igG cross the placenta?






31. What cytokines do macrophages release? who else can secrete IL 6? IL 12?






32. Describe the interstitial tissue of a spleen including the sinuses. What type of cells are found in the four structures (cortex - paracortex - medulla and sinuses)?






33. Which disease is associated with DR3?






34. what happens in a deficiency of C1 esterase inhibitor? DAF?






35. What is the presentation of common variable immunodef? and What are the labs?






36. What is the common variable immunodeficiency ? How is it different from Brutons?






37. Give three examples of bacteria that use antigenic variation and how.






38. What are the main symptoms of B cell immunodeficiencies?






39. What does IL 5 do?






40. Name 5 ways Antibody diversity is generated?






41. What is Aldesleukin? What is it used for






42. To what disease do the autoantibodies to IgG (rheumatoid factor)?






43. What type of fenestrations are found in the red pulp of the spleen?






44. What is the clinical use for azathioprine?






45. What are the function of B cells?






46. How does igA cross the epithelium?






47. What part of the lymph node specifically expands during a cellular immune response? when would this occur?






48. Which are the only two antiinflammatory cytokines?






49. What is recomb beta interferon used for?






50. All transplant rejections - _____________ are mediated by Type IV hypersensitivity