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USMLE Step 1 Immunology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is recomb beta interferon used for?






2. What are the main cell surface proteins on B cells?






3. What type of side chains are found on Fc region of an antibody?






4. How does complement link innate and adaptive?






5. other than C3a - what other complement acts as an anaphyloxin?






6. What type of cells do NK cells attack? with What tools? by necrosis or apoptosis?






7. What is the pathogenesis of a hypersensitivity reaction?






8. What are the autoantibodies for primary biliary cirrhosis?






9. What is serum sickness? give an example.






10. What is a type I hypersensitivity reaction? What is atopic?






11. Which is the main antibody that provides passive immunity to infants?






12. What does IL 4 do?






13. which antibodies can bind complement?






14. Which disease is associated with DR3?






15. What is the defect in Brutons agammaglobulinemia? What is its effect on B cells? What is its inheritance pattern?






16. What is passive immunity?






17. What is epo used for?






18. What are the autoantibodies for drug induced lupus?






19. What is the white pulp of the spleen?






20. What lymph node drains the sigmoid colon?






21. hat is the presentation of Jobs syndrome or Hyper IgE?






22. what results in symptoms of shock in an acute hemolytic transfusion reaction?






23. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>






24. What is the marginal zone of the spleen? what happens there?






25. What are the autoantibodies for goodpastures syndrome?






26. describe the classic complement pathway.






27. What are MHC's necessary for? By themselves?






28. What are the main Cell surface proteins on T cells?






29. What is the mechanism for sirolimus? what else it known as?






30. How fast does it occur?






31. What is the main cytokine released by T cells? What does it do






32. What is thrombopoietin used for?






33. The MALT/GALT are not...






34. What are the labs in brutons agammaglobulinemia?






35. If the alternative pathway is constitively active - how come normal cells don't get attacked with MAC?






36. How does igA cross the epithelium?






37. What is the main function of interferons?






38. What is the pathogenesis of HyperIgE syndrome? What are the labs?






39. give an example of how influenza does a major antigenic shift.






40. What lymph node drains the testes?






41. Which are the only two antiinflammatory cytokines?






42. What is digoxin immune Fab used for?






43. What is the toxicity of muromonab?






44. what ensure that a memory response is generated?






45. The two heavy chains of an antibody contribute to the...






46. The ______ in the BM are DN - the DP are in the cortex of thymus






47. are Th cells involved in trapping of antigens of endotoxin/LPS?






48. All transplant rejections - _____________ are mediated by Type IV hypersensitivity






49. From where do cytokines come from?






50. Leukocyte adhesion defect presents with...