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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are signs of Sildenafil (Viagra) toxicity?






2. Why does NE result in bradycardia?






3. What effect would atropine have on the preganglionic sympathetic activation of sweat glands? Would this person sweat?






4. Which drug(s) cause this reaction: Thrombotic complications?






5. What type of patient should not take Misoprostol and why?






6. How do spare receptors effect the Km?






7. Can Heparin be used during pregnancy?






8. What is the memory key for Metronidazole's clinical uses?






9. Antiarrhythmic class IB- effects?






10. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






11. List the mechanism - clinical use - & toxicity of Paclitaxel.






12. Foscarnet does not require activation by a...






13. Antiarrhythmic Class III- effects?






14. What is the category of drug names ending in - triptyline (e.g. Amitriptyline)






15. What is the mechanism of action and clinical use of the antiandrogens Ketoconazole and Spironolactone?






16. Which drug(s) cause this reaction: Hepatitis?






17. Which drug(s) cause this reaction: Anaphylaxis?






18. What conditions would you use dantrolene?






19. What is Ketoconazole specifically used for?






20. What are four H2 Blockers?






21. When is Rifampin not used in combination with other drugs?






22. How is Griseofulvin used clinically?






23. How can Isoniazid (INH)- induced neurotoxicity be prevented?






24. Hydrochlorothiazide - mechanism?






25. Antiarrhythmic class IC- toxicity?






26. List the mechanism - clinical use - & toxicity of 5 FU.






27. What is the MOA for the Tetracyclines?






28. What microorganisms are Aminoglycosides ineffective against?






29. MOA: Block nucleotide synthesis






30. Which Aminoglycoside is used for Bowel Surgery ?






31. What is the memory key for the effect of aluminum hydroxide overuse?






32. List the specific antidote for this toxin: Amphetamine






33. Classes of antihypertensive drugs?






34. Preferential action of the Ca2+ channel blockers at cardiac muscle?






35. How is Rifampin used clinically?






36. What is the MOA for Vancomycin?






37. What is the clinical utility of cocaine?






38. What is the mechanism of action of Acetaminophen?






39. What are five disadvantages of Oral Contraceptives (synthetic progestins - estrogen)?






40. Which diuretics cause alkalosis?






41. Bretyllium - toxicity?






42. For Warfarin What is the Duration of action






43. What are Polymyxins used for?






44. Name several common Macrolides (3)






45. What are three common NSAIDS other than Aspirin?






46. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






47. MOA: Bactericidal antibiotics






48. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






49. What would be the effect on blood pressure with infusion of the alpha -2 agonist clonidine?






50. What is the chemical name for Ganciclovir?