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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. MOA: Block protein synthesis at 30s subunit






2. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






3. Ca2+ channel blockers - toxicity?






4. Why would dopamine be useful in treating shock?






5. Adverse effects of Reserpine?






6. As an Anes you want to use a depolarizing neuromuscular blocking drug on your pt - What do you use






7. What is the MOA for the Fluoroquinolones?






8. How can the t1/2 of INH be altered?






9. What is the lab value used to monitor the effectiveness of Warfarin therapy?






10. K+ sparing diuretics - site of action?






11. What is the MOA for Nystatin?






12. What enzyme does Zileuton inhibit?






13. Cautions When using Amiodarone?






14. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






15. What is the category of drug names ending in - oxin (e.g. Digoxin)






16. What anticholinesterase crosses the blood - brain - barrier?






17. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






18. What is the major side effect for Carbenicillin - Piperacillin - and Ticarcillin?






19. A 57 yo heart failure pt develops cardiac decompensation - What drug will give you adequate perfusion of his kidneys as well as tx for his Hypotension






20. What are three possible complications of Heparin therapy?






21. For Warfarin What is the Onset of action






22. List the specific antidote for this toxin: Acetaminophen






23. Thiazides - site of action?






24. What is the MOA for Amphotericin B?






25. For Heparin What is the Site of action






26. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






27. Preferential action of the Ca2+ channel blockers at cardiac muscle?






28. Name the common Fluoroquinolones (6)






29. What is treated with Chloroquine - Quinine - Mefloquine?






30. What microorganisms is Aztreonam not effective against?






31. Adverse effects of Hydralazine?






32. Which cancer drugs work at the level of proteins(2)?






33. Which drug(s) cause this reaction: Tendonitis and rupture?






34. Ibutilide - toxicity?






35. What are toxicities associated with Chloramphenicol?






36. Sotalol - toxicity?






37. What is the category of drug names ending in - azol (e.g. Ketoconazole)






38. What drugs target anticholinesterase






39. What are the clinical uses for Aztreonam?






40. Adverse effect of Nitroprusside?






41. List the mechanism - clinical use - & toxicity of Nitrosureas.






42. Name three K+ sparing diuretics?






43. Which drug(s) cause this reaction: Hot flashes?






44. Which drug(s) cause this reaction: SLE- like syndrome?






45. What are the products and their toxicities of the metabolism of Ethylene Glycol by / alcohol dehydrogenase?






46. Furosemide - toxicity? (OH DANG)






47. What is the mechanism of action of the glucocorticoids?






48. Acetazolamide - clinical uses?






49. Explain potency in relation to full and partial agonists(2).






50. MOA: Bactericidal antibiotics







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