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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name the common Fluoroquinolones (6)






2. What is Imipenem always administered with?






3. What are the clinical uses for 1st Generation Cephalosporins?






4. Furosemide increases the excretion of What ion?






5. Isopoterenol was given to a patient with a developing AV block - why?






6. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






7. Which of the following would atropine administration cause? Hypothermia - bradycardia - excess salivation - dry flushed skin - or diarrhea






8. ACE inhibitors - toxicity?






9. Digoxin v. Digitoxin: bioavailability?






10. What is the category of drug names ending in - azol (e.g. Ketoconazole)






11. Which drug(s) cause this reaction: Agranulocytosis (3)?






12. How is Amantadine used clinically?

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13. What is the MOA for the Cephalosporins?






14. Which drug(s) cause this reaction: Gingival hyperplasia?






15. What are Aminoglycosides synergistic with?






16. What is the mechanism of action of Cyclosporine?






17. How would you reverse the effect of a neuromuscular blocking agent?






18. What are are the Sulfonylureas (general description) and What is their use?






19. Why are the Sulfonylureas inactive in IDDM (type -1)?






20. MOA: Block protein synthesis at 50s subunit






21. What is the difference in receptor affinity of epinephrine at low doses? High doses?

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22. For Heparin What is the Structure






23. Steady state concentration is reached in __ number of half - lifes






24. List the mechanism - clinical use - & toxicity of Tamoxifen.






25. When is Rifampin not used in combination with other drugs?






26. What is the mechanism of action of Probenacid used to treat chronic gout?






27. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






28. How is Trimethoprim used clinically?






29. What are the clinical uses for 2nd Generation Cephalosporins?






30. Preferential action of the Ca2+ channel blockers at cardiac muscle?






31. What are the major structural differences between Penicillin and Cephalosporin?






32. List the mechanism - clinical use - & toxicity of Doxorubicin.

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33. What is the MOA for Acyclovir?






34. What is the clinical use for Clomiphene?






35. Which cancer drugs work at the level of mRNA(2)?






36. What is a common drug interaction associated with Griseofulvin?






37. List the mechanism - clinical use - & toxicity of Methotrexate.






38. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






39. What is the MOA of Ribavirin?






40. Adverse effects of Nifedipine - verapamil?






41. MOA: Block peptidoglycan synthesis






42. What are the classic symptoms of cholinesterase inhibitor poisoning (parathion or other organophosphates)?






43. What is the category and mechanism of action of Zileuton in Asthma treatment?






44. Digoxin v. Digitoxin: excretion?






45. Resistance mechanisms for Macrolides

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46. Antiarrhythmic class IV- primary site of action?






47. What physiological effects was the Anes using Atropine to tx






48. What beta 2 agonist will help your 21yo Astma pt?






49. What are the clinical indications for bethanechol?






50. Foscarnet toxicity?