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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Resistance mechanisms for Tetracycline






2. What is the mechanism of action and clinical use of the antiandrogens Ketoconazole and Spironolactone?






3. What is the category of drug names ending in - oxin (e.g. Digoxin)






4. Antimicrobial prophylaxis for Syphilis






5. What are the major structural differences between Penicillin and Cephalosporin?






6. Reserpine will block the syntheis of this drug and but not its precursor.






7. Acetazolamide - site of action?






8. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






9. What sympathomimetic would you not prescribe for hypotension in a pt with renal artery sclerosis.






10. What are the clinical uses for Ticlopidine - Clopidogrel?






11. List the mechanism - clinical use - & toxicity of Paclitaxel.






12. What is the mechanism of action of Probenacid used to treat chronic gout?






13. Ca2+ channel blockers - site of action?






14. List the specific antidote for this toxin: Methemoglobin






15. Which drug(s) cause this reaction: Aplastic anemia (5)?






16. Why is Cilastatin administered with Imipenem?






17. Procainamide - toxicity?






18. Triamterene and amiloride - mechanism?






19. What is Fluconazole specifically used for?






20. Which drug(s) cause this reaction: P450 inhibition(6)?






21. List the specific antidote for this toxin: Lead






22. Adverse effects of Hydrochlorothiazide?






23. What enzyme does Zileuton inhibit?






24. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






25. What is clinical use for Carbenicillin - Piperacillin - and Ticarcillin?






26. Specifically - How does Foscarnet inhibit viral DNA pol?






27. Cautions When using Amiodarone?






28. Name four HMG- CoA reductase inhibitors.






29. Furosemide - toxicity? (OH DANG)






30. What is a sign of toxicity with the use of thrombolytics?






31. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






32. Name the common Fluoroquinolones (6)






33. Which drug(s) cause this reaction: Cutaneous flushing (4)?






34. Name two classes of drugs for HIV therapy






35. What is the category of drug names ending in - phylline (e.g. Theophylline)






36. What are three toxicities of Propylthiouracil?






37. What are the major toxic side effects of Imipenem/cilastatin?






38. Explain differences between full and partial agonists(2).






39. How is Ganciclovir activated?






40. What are Aminoglycosides synergistic with?






41. What type of gout is treated with Probenacid?






42. What are two conditions in Which COX-2 inhibitors might be used?






43. What is combination TMP- SMZ used to treat?






44. Sotalol - toxicity?






45. How is Acyclovir used clinically?






46. Ryanodine - site of action?






47. A 57 yo heart failure pt develops cardiac decompensation - What drug will give you adequate perfusion of his kidneys as well as tx for his Hypotension






48. Furosemide - clinical use?






49. What are two clinical uses of Azathioprine?






50. What are two Glitazones?