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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Is resistant to penicillinase?






2. What beta 2 agonist will help your 21yo Astma pt?






3. Describe the MOA of Interferons (INF)






4. What is the mechanism of action of Misoprostol?






5. What is the mechanism of action of Ticlopidine - Clopidogrel






6. Adverse effects of Nifedipine - verapamil?






7. Side effects of Isoniazid (INH)?






8. What is the MOA of the RT Inhibitors?






9. What are the phases of succinylcholine neuromuscular blockade?






10. Adverse effects of Losartan?






11. What are common toxicities associated with Macrolides? (4)






12. Which drug(s) cause this reaction: Fanconi's syndrome?






13. What are three possible complications of Heparin therapy?






14. What is a common side effect of Colchicine used to treat acute gout - especially When given orally?






15. Name common Polymyxins






16. List the specific antidote for this toxin: Cyanide






17. What is the MOA of Ganciclovir?






18. In coma situations you rule out What (7)?

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19. Name the common Non - Nucleoside Reverse Transcriptase Inhibitors






20. What are two Glitazones?






21. What drug is used during the pregnancy of an HIV+ mother? - Why?






22. What is the clinical use for Sucralfate?






23. What is the category - mechanism of action - and effect of Ipratroprium in Asthma treatment?






24. Bretyllium - toxicity?






25. Which cancer drugs work at the level of mRNA(2)?






26. Which diuretics cause acidosis?






27. What is a prerequisite for Acyclovir activation?






28. Name three Antiarrhythmic drugs in class IB.






29. Adenosine - clinical use?






30. Antiarrhythmic class IV- toxicity?






31. List the specific antidote for this toxin: Digitalis






32. How would you treat African Trypanosomiasis (sleeping sickness)?






33. What neurotransmitter does Amantadine affect? How does it influence this NT?






34. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






35. What is the category - desired effect - and adverse effect of Isoproterenol in the treatment of Asthma?






36. Mannitol - site of action?






37. What is the clinical utility of clonidine?






38. Which drug(s) cause this reaction: Adrenocortical Insufficiency






39. List the specific antidote for this toxin: Benzodiazepines






40. How can Isoniazid (INH)- induced neurotoxicity be prevented?






41. What is the formula for Volume of distribution (Vd)






42. Antiarrhythmic class II- effects?






43. Do Tetracyclines penetrate the CNS?






44. What are the major structural differences between Penicillin and Cephalosporin?






45. What is an additional side effect of Methicillin?






46. What are five possible toxic effects of Aspirin therapy?

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47. Beta Blockers - CNS toxicity?






48. What enzyme does Zileuton inhibit?






49. Resistance mechanisms for Sulfonamides






50. Verapamil has similar action to?