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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the clinical indications for Azole therapy?






2. Adverse effects of ganglionic blockers?






3. How does a competitive antagonist effect an agonist?






4. What are two clinical uses of Azathioprine?






5. How can the toxic effects of TMP be ameliorated?






6. What are four clinical uses of glucocorticoids?

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7. What type of gout is treated with Colchicine?






8. Aztreonam ________ to penicillinase






9. ACE inhibitors - clinical use?






10. What are three toxicities of Leuprolied?






11. Antiarrhythmic class IV- effects?






12. Decrease Digitoxin dose in renal failure?






13. What is the MOA for Methicillin - Nafcillin - and Dicloxacillin?






14. What are the four conditions in Which Omeprazole - Lansoprazole is used?






15. What is the clinical use for Heparin?






16. Toxicities associated with Acyclovir?






17. Which drug(s) cause this reaction: Adrenocortical Insufficiency






18. Mannitol - toxicity?






19. What is the clinical use for Ampicillin and Amoxicillin?






20. Which drug(s) cause this reaction: Gingival hyperplasia?






21. What are two Alpha - glucosidase inhibitors?






22. What effect would atropine have on a patient with peptic ulcer disease?






23. Digoxin v. Digitoxin: protein binding?






24. Dobutamine used for the tx of shock acts on Which receptors






25. Adverse effects of Prazosin?






26. Why would you give a drug like pancuronium or succinylcholine?






27. Beta Blockers - CNS toxicity?






28. What drug is given for Pneumocystis carinii prophylaxis?






29. What are the side effects of Rifampin?






30. What are common side effects of RT Inhibitors?






31. How do you calculate maintenance dose?






32. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






33. What are the clinical uses for Aztreonam?






34. Which drug(s) cause this reaction: P450 induction(6)?






35. Resistance mechanisms for Vancomycin






36. What is the MOA for the Aminoglycosides?






37. What are five toxicities associated with Tacrolimus (FK506)?






38. What is the effect of TCA's on the adrenergic nerve?






39. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






40. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






41. ADH antagonists - site of action?






42. Name the common Azoles






43. What is the MOA for the Macrolides?






44. Resistance mechanisms for Chloramphenicol






45. What are major side effects of Methicillin - Nafcillin - and Dicloxacillin?






46. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






47. What are the major toxic side effects of Imipenem/cilastatin?






48. Amiodarone - toxicity?






49. Cocaine shares is mechanism of action with What antidepressant






50. List five common glucocorticoids.