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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is Imipenem always administered with?






2. What is the clinical use for Sucralfate?






3. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






4. List the specific antidote for this toxin: Arsenic (all heavy metals)






5. Antiarrhythmic class IV- toxicity?






6. Name the common Azoles






7. K+ sparing diuretics - clinical use?






8. Which of the following would atropine administration cause? Hypothermia - bradycardia - excess salivation - dry flushed skin - or diarrhea






9. Nifedipine has similar action to?






10. What Sulfonamides are used for simple UTIs?






11. In What population does Gray Baby Syndrome occur? Why?






12. How are Interferons (INF) used clinically?

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13. Furosemide - clinical use?






14. What are three complications of Warfarin usage?






15. What are the major toxic side effects of Imipenem/cilastatin?






16. Describe Phase I metabolism in liver(3)?






17. What is the clinical use for Heparin?






18. What are two indirect acting adrenergic agonists?






19. For Heparin What is the Treatment for overdose






20. How do we stop angina?






21. How is Amantadine used clinically?

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22. Which of epi - norepi - or isoproterenol results in bradycardia?






23. Ibutilide - toxicity?






24. What is a possible toxicity of Alpha - glucosidase inhibitors used in type -2 diabetes?






25. What populations are Floroquinolones contraindicated in? Why?






26. What is the MOA for Trimethoprim (TMP)?






27. MOA: Block nucleotide synthesis






28. What is clinical use for Carbenicillin - Piperacillin - and Ticarcillin?






29. What drug is given for Pneumocystis carinii prophylaxis?






30. Which drug(s) cause this reaction: Diabetes insipidus?






31. Antiarrhythmic class IV- effects?






32. Which drug increases Sys BP w/o affecting Pulse Pressure






33. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






34. What are toxic side effects for Metronidazole?






35. Which drug(s) cause this reaction: Cardiac toxicity?






36. What is the formula for Clearance (CL)






37. List the mechanism - clinical use - & toxicity of Etoposide.






38. What is the possible mechanism and effect of Metformin in treating diabetes?






39. Acetazolamide - toxicity?






40. Which antimicrobial classes inhibit protein synthesis at the 30S subunit? (2)






41. ________ ae not resistant to penicillinase - - but they are less susceptible than the other Beta lactams






42. Name the steps in drug approval(4)?






43. What are common serious side effects of Aminoglycosides and What are these associated with?






44. What organisms does Griseofulvin target?






45. Adverse effects of Prazosin?






46. Which drug(s) cause this reaction: Cough?






47. Beta Blockers - BP?






48. MOA: Block peptidoglycan synthesis






49. What antimicrobial class is Aztreonam syngergestic with?






50. How does a competitive antagonist effect an agonist?