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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Acetazolamide - clinical uses?






2. Does Heparin have a long - medium - or short half life?






3. Why would you use pralidoxime after exposure to an organophosphate?






4. What are common side effects of RT Inhibitors?






5. How are the HIV drugs used clinically?

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6. What are three types of antacids and the problems that can result from their overuse?






7. Digoxin v. Digitoxin: protein binding?






8. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






9. What are the clinical uses for Aztreonam?






10. How does NE modulate its own release? What other neurotransmitter has this same effect?






11. What is the category of drug names ending in - navir (e.g. Saquinavir)






12. For Warfarin What is the Lab value to monitor






13. Which cancer drugs inhibit nucleotide synthesis(3)?






14. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






15. What is the mechanism of action of the thrombolytics?






16. MOA: Block protein synthesis at 30s subunit






17. Which drug(s) cause this reaction: Fanconi's syndrome?






18. Which diuretics increase urine NaCl?






19. What is a mnemonic to remember Amantadine's function?






20. What is the mecanism of action of Sucralfate?






21. Mg+- clinical use?






22. List the mechanism - clinical use - & toxicity of Etoposide.






23. What are three possible complications of Heparin therapy?






24. What is the memory key for the effect of aluminum hydroxide overuse?






25. What is the receptor affinity and clinical use of isoproterenol?






26. Which drug(s) cause this reaction: G6PD hemolysis(8)?






27. For Warfarin What is the Mechanism of action






28. Which drug(s) cause this reaction: P450 inhibition(6)?






29. Antiarrhythmic class IB- effects?






30. Adverse effects of Captopril?






31. How is Amphotericin B administered for fungal meningitis?






32. Name two classes of drugs for HIV therapy






33. Adverse effects of Nifedipine - verapamil?






34. What antimuscarinic agent is used in asthma and COPD?






35. What is the MOA for Acyclovir?






36. What anticholinesterase crosses the blood - brain - barrier?






37. How does Ganciclovir's toxicity relate to that of Acyclovir?






38. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






39. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






40. What is the category of drug names ending in - tropin (e.g. Somatotropin)






41. What is the category of drug names ending in - zosin (e.g. Prazosin)






42. Common toxicities associated with Griseofulvin?






43. What is Metronidazole used for clinically?






44. What do Aminoglycosides require for uptake?






45. What type of neurological blockade would hexamethonium create?






46. Name four Antiarrhythmic drugs in class IA.






47. Amiodarone - toxicity?






48. Foscarnet toxicity?






49. What is the category of drug names ending in - triptyline (e.g. Amitriptyline)






50. Why is reserpine effective in treating HTN?