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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Beta Blockers - CV toxicity?






2. What are three toxicities of Leuprolied?






3. Name the common Nucleoside Reverse Transcriptase Inhibitors






4. List the specific antidote for this toxin: TPA & Streptokinase






5. What organism is Imipenem/cilastatin the Drug of Choice for?






6. What is the effect of the Glitazones in diabetes treatment?






7. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






8. Ca2+ channel blockers - toxicity?






9. List the specific antidote for this toxin: Beta Blockers






10. What are common side effects of RT Inhibitors?






11. Why would you use pralidoxime after exposure to an organophosphate?






12. What process does Zafirlukast interfere with?






13. Name three calcium channel blockers?






14. What is the mechanism of action of the thrombolytics?






15. Why are the Sulfonylureas inactive in IDDM (type -1)?






16. What is the MOA for Trimethoprim (TMP)?






17. Adverse effects of Nifedipine - verapamil?






18. What drugs target anticholinesterase






19. Explain differences between full and partial agonists(2).






20. Foscarnet does not require activation by a...






21. List the specific antidote for this toxin: Anticholinesterases (organophosphate.)






22. Hydralazine - clinical use?






23. Foscarnet toxicity?






24. What is Fluconazole specifically used for?






25. Amprotericin B ___________ the BBB






26. What are two toxicities of the Sulfonylureas?






27. What is the chemical name for Ganciclovir?






28. Which of the following would atropine administration cause? Hypothermia - bradycardia - excess salivation - dry flushed skin - or diarrhea






29. What is the clinical use of Mifepristone (RU486)?






30. Adenosine - clinical use?






31. Antimicrobial prophylaxis for a history of recurrent UTIs






32. For Heparin What is the Lab value to monitor






33. What are the clinical indications for neostigmine?






34. What are Fluoroquinolones indicated for? (3)






35. What is Clindamycin used for clinically?






36. Which drug(s) cause this reaction: Oto and Nephrotoxicity (3)?






37. What is the MOA for Metronidazole?






38. Which H2 Blocker has the most toxic effects and What are they?






39. For Heparin What is the Onset of action






40. Beta Blockers - site of action?






41. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






42. How is Amphotericin B administered for fungal meningitis?






43. What is the MOA for the Aminoglycosides?






44. Hydrochlorothiazide - toxicity? (hyperGLUC - plus others)






45. Why does NE result in bradycardia?






46. Mannitol - site of action?






47. How is Chloramphenical used clinically?






48. What musculo - skeletal side effects in Adults are associated with Floroquinolones?






49. What Sulfonamides are used for simple UTIs?






50. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






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