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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Why is carbachol and pilocarpine useful in treatment of glaucoma?






2. Quinidine - toxicity?






3. Adverse effects of Clonidine?






4. Name some common Sulfonamides (4)






5. For Warfarin What is the Duration of action






6. Name four HMG- CoA reductase inhibitors.






7. Which diuretics increase urine K+?






8. Digoxin v. Digitoxin: half life?






9. What is the category of drug names ending in - caine (e.g. Lidocaine)






10. What are two types of drugs that interfere with the action of Sucralfate and why?






11. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






12. How would hemicholinium treatment affect cholinergic neurons?






13. Which drug(s) cause this reaction: Cinchonism (2)?






14. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






15. What is the mechanism of action of Sildenafil (Viagra)?






16. What is the mechanism of action of Misoprostol?






17. Foscarnet does not require activation by a...






18. How is Trimethoprim used clinically?






19. What is the mechanism of action of Heparin?






20. Name five Antiarrhythmic drugs in class II?






21. Guanethidine enhances the release of Norepi?






22. Mannitol - clinical use?






23. Name three ACE inhibitors?






24. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






25. What are four clinical uses of glucocorticoids?

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26. For Warfarin What is the Mechanism of action






27. What is the clinical use of Mifepristone (RU486)?






28. How is Ribavirin used clinically?






29. Are penicillinase resistant






30. What is the category of drug names ending in - barbital (e.g. Phenobarbital)






31. What is the clinical use for Warfarin?






32. Ca2+ channel blockers - mechanism?






33. What are common toxicities associated with Tetracyclines?

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34. What are the nondepolarizing neuromuscular blocking drugs?






35. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






36. Which drug(s) cause this reaction: Oto and Nephrotoxicity (3)?






37. List the specific antidote for this toxin: Iron






38. Resistance mechanisms for Sulfonamides






39. What are toxic side effects for Metronidazole?






40. What is the possible mechanism and effect of Metformin in treating diabetes?






41. Mg+- clinical use?






42. Reserpine will block the syntheis of this drug and but not its precursor.






43. Hydralazine - class and mechanism?






44. What are five toxicities associated with Tacrolimus (FK506)?






45. Name two classes of drugs for HIV therapy






46. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






47. Which drug(s) cause this reaction: Gingival hyperplasia?






48. What is the category of drug names ending in - olol (e.g. Propranolol)






49. Adverse effects of Hydrochlorothiazide?






50. What is the category - desired effect - and period of use of albuterol in the treatment of Asthma?