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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






2. Digoxin v. Digitoxin: protein binding?






3. List the specific antidote for this toxin: Opioids






4. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






5. ACE inhibitors - mechanism?






6. List the specific antidote for this toxin: Antimuscarinic (anticholinergic)






7. Digoxin v. Digitoxin: half life?






8. Which drug(s) cause this reaction: Cutaneous flushing (4)?






9. What is the mechanism of action of Acetaminophen?






10. What are the clinical uses for Imipenem/cilastatin?






11. Why are the Sulfonylureas inactive in IDDM (type -1)?






12. For Heparin What is the Mechanism of action






13. How would you treat African Trypanosomiasis (sleeping sickness)?






14. How is Amphotericin B administered for fungal meningitis?






15. What organism is Imipenem/cilastatin the Drug of Choice for?






16. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






17. Which drug(s) cause this reaction: Atropine - like side effects?






18. What is the MOA of Ganciclovir?






19. What is the lab value used to monitor the effectiveness of Warfarin therapy?






20. Adverse effects of Hydralazine?






21. What are the major toxic side effects of Imipenem/cilastatin?






22. What is the category of drug names ending in - pril (e.g. Captopril)






23. How is Rifampin used clinically?






24. Your patient wants an effective drug to treat his motion sickness - What would you prescribe






25. Name two LPL stimulators.






26. What is the MOA for Ampicillin and Amoxicillin?






27. What is the category of drug names ending in - operidol (e.g. Haloperidol)






28. What type of patient should not take Misoprostol and why?






29. What is an additional side effect of Methicillin?






30. What is a sign of toxicity with the use of thrombolytics?






31. Verapamil has similar action to?






32. How does Ganciclovir's toxicity relate to that of Acyclovir?






33. Is toxicity rare or common whith Cromolyn used in Asthma prevention?






34. Foscarnet toxicity?






35. Antiarrhythmic class II- mechanism?






36. Would blockade of muscarininc receptors in the bladder be useful in treating urinary retention?






37. How do Sulfonamides act on bacteria?






38. List the mechanism - clinical use - & toxicity of Paclitaxel.






39. What can result due to antacid overuse?






40. What are the major structural differences between Penicillin and Cephalosporin?






41. Which drug(s) cause this reaction: Hot flashes?






42. Furosemide increases the excretion of What ion?






43. What is the MOA of Amantadine?






44. Name the common Aminoglycosides (5)






45. How do you treat coma in the ER (4)?






46. Which diuretics cause alkalosis?






47. Which cancer drugs work at the level of mRNA(2)?






48. What are are the Sulfonylureas (general description) and What is their use?






49. How is Amphotericin B used clinically?






50. How does angiotensin II affect NE release?