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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the mechanism of action of Allopurinol used to treat chronic gout?






2. IV Penicillin






3. What reversal agent could a Anes give to reverse the effects of Atropine






4. Why is pyridostigmine effective in the treatment of myasthenia gravis?






5. Amiodarone - toxicity?






6. What is the category of drug names ending in - navir (e.g. Saquinavir)






7. How does a noncompetitive antagonist effect an agonist?






8. Which drug(s) cause this reaction: P450 inhibition(6)?






9. What is the mechanism of action of Warfarin (Coumadin)?






10. What are the clinical uses for Aztreonam?






11. What are four advantages of newer low - molecular - weight heparins (Enoxaparin)?






12. Mannitol - clinical use?






13. Does Ampicillin or Amoxicillin have a greater oral bioavailability?






14. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






15. What is the MOA of Ribavirin?






16. Name common Polymyxins






17. What is the memory key for Isoniazid (INH) toxicity?






18. What should not be taken with Tetracyclines? / Why?






19. What is the main clinical use for the thrombolytics?






20. List the mechanism - clinical use - & toxicity of Prednisone.

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21. What is the MOA of Foscarnet?






22. Adverse effects of Hydrochlorothiazide?






23. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






24. Digoxin v. Digitoxin: half life?






25. What is the category of drug names ending in - triptyline (e.g. Amitriptyline)






26. List the specific antidote for this toxin: Carbon monoxide






27. Adverse effects of Loop Diuretics?






28. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






29. Sotalol - toxicity?






30. Which drug(s) cause this reaction: Stevens - Johnson syn. (3)?






31. Antiarrhythmic class IB- toxicity?






32. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






33. Name four HMG- CoA reductase inhibitors.






34. Reserpine will block the syntheis of this drug and but not its precursor.






35. ___________ are Teratogenic






36. Which of the following would atropine administration cause? Hypothermia - bradycardia - excess salivation - dry flushed skin - or diarrhea






37. What is the category and mechanism of action of Zafirlukast in Asthma treatment?






38. What are two toxicities of the Glitazones?






39. Which drug(s) cause this reaction: Atropine - like side effects?






40. Amprotericin B ___________ the BBB






41. Name the Protease Inhibitors (4)






42. What are common side effects of Amphotericin B?






43. What is the effect of norepinephrine on bp and pulse pressure?






44. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






45. What are signs of Sildenafil (Viagra) toxicity?






46. MOA: Block protein synthesis at 30s subunit






47. List some specifics of lead poisoning(4)?






48. What are common toxicities associated with Macrolides? (4)






49. What is the category of drug names ending in - cycline (e.g. Tetracycline)






50. What physiological effects was the Anes using Atropine to tx