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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are Aminoglycosides used for clinically?






2. MOA: Block nucleotide synthesis






3. Explain potency in relation to full and partial agonists(2).






4. What is the mechanism of action of Cyclosporine?






5. Ca2+ channel blockers - mechanism?






6. What is the major side effect for Carbenicillin - Piperacillin - and Ticarcillin?






7. Procainamide - toxicity?






8. What are nine findings of Iatrogenic Cushing's syndrome caused by glucocorticoid therapy?






9. Antimicrobial prophylaxis for Gonorrhea






10. What are four conditions in Which H2 Blockers are used clinically?






11. Steady state concentration is reached in __ number of half - lifes






12. What are three types of antacids and the problems that can result from their overuse?






13. List the mechanism - clinical use - & toxicity of 5 FU.






14. What is the MOA of Foscarnet?






15. What are three clinical uses of the NSAIDs?






16. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






17. What organisms does Griseofulvin target?






18. What are toxicities associated with Chloramphenicol?






19. Ethacrynic Acid - clinical use?






20. K+- clinical use?






21. Name some common Tetracyclines (4)






22. Name common Polymyxins






23. What are two mechanisms of action of Propythiouracil?






24. Beta Blockers - site of action?






25. Which drug(s) cause this reaction: Gingival hyperplasia?






26. What are the clinical uses for Aztreonam?






27. How are Sulfonamides employed clinically?






28. Are penicillinase resistant






29. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?






30. Name three Antiarrhythmic drugs in class IV.






31. What is the mechanism of action of the Sulfonylureas?






32. What type of gout is treated with Probenacid?






33. What is the MOA of Ganciclovir?






34. ACE inhibitors - toxicity?






35. Hydralazine - toxicity?






36. What is the clinical use for Nystatin?






37. How does a noncompetitive antagonist effect an agonist?






38. What is Fluconazole specifically used for?






39. Which drug(s) cause this reaction: Pseudomembranous colitis?






40. Adverse effect of Nitroprusside?






41. What are the major toxic side effects of Imipenem/cilastatin?






42. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






43. Name four Antiarrhythmic drugs in class IA.






44. What is the category of drug names ending in - azine (e.g. Chlorpromazine)






45. How would you reverse the effect of a neuromuscular blocking agent?






46. What is the clinical use for Sildenafil (Viagra)?






47. Adverse effects of Losartan?






48. What is a Ribavirin toxicity?






49. What additional side effects exist for Ampicillin?






50. What are three clinical uses of the Leuprolide?






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