Test your basic knowledge |

USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Aztreonam is not ________ with penicillins






2. Beta Blockers - site of action?






3. What are three possible complications of Heparin therapy?






4. Which drug(s) cause this reaction: Torsade de pointes (2)?






5. What additional side effects exist for Ampicillin?






6. Which cancer drugs work at the level of mRNA(2)?






7. Why is Cilastatin administered with Imipenem?






8. What is a mnemonic to remember Amantadine's function?






9. Ca2+ channel blockers - toxicity?






10. What are four conditions in Which H2 Blockers are used clinically?






11. Antiarrhythmic class IV- clinical use?






12. What is the mechanism of action and clinical use of the antiandrogens Ketoconazole and Spironolactone?






13. List some specifics of lead poisoning(4)?






14. Which of epi - norepi - or isoproterenol results in bradycardia?






15. What is the lab value used to monitor the effectiveness of Warfarin therapy?






16. What is are two clinical uses of Cyclosporine?






17. What is the category of drug names ending in - barbital (e.g. Phenobarbital)






18. Resistance mechanisms for Chloramphenicol






19. What are two toxicities of the Glitazones?






20. Which diuretics increase urine K+?






21. Why are the Sulfonylureas inactive in IDDM (type -1)?






22. List the specific antidote for this toxin: Carbon monoxide






23. Digoxin v. Digitoxin: bioavailability?






24. What process does Zafirlukast interfere with?






25. How are the HIV drugs used clinically?

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26. What is the memory key for the effect of aluminum hydroxide overuse?






27. What is the formula for Clearance (CL)






28. In coma situations you rule out What (7)?

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29. Why would dopamine be useful in treating shock?






30. What organisms does Griseofulvin target?






31. List the specific antidote for this toxin: Tricyclic antidepressants






32. Resistance mechanisms for Sulfonamides






33. What is Nifurtimox administered for?

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34. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






35. Why is pyridostigmine effective in the treatment of myasthenia gravis?






36. Acetazolamide - toxicity?






37. MOA of Succinylcholine






38. How can the t1/2 of INH be altered?






39. Adverse effects of Hydralazine?






40. Name three Antiarrhythmic drugs in class IB.






41. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






42. What are common side effects of Amphotericin B?






43. What is the category of drug names ending in - phylline (e.g. Theophylline)






44. What is the mechanism of action of Mifepristone (RU486)?






45. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






46. Which drug(s) cause this reaction: Tendonitis and rupture?






47. What is the category - desired effect - and period of use of albuterol in the treatment of Asthma?






48. List the mechanism - clinical use - & toxicity of Paclitaxel.






49. Which drug(s) cause this reaction: Anaphylaxis?






50. List the mechanism - clinical use - & toxicity of Nitrosureas.