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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antimicrobial prophylaxis for a history of recurrent UTIs






2. What are the products and their toxicities of the metabolism of Ethylene Glycol by / alcohol dehydrogenase?






3. What is the effect of norepinephrine on bp and pulse pressure?






4. How is Ribavirin used clinically?






5. List the specific antidote for this toxin: Warfarin






6. What antimuscarinic agent is used in asthma and COPD?






7. Name the steps in drug approval(4)?






8. What are three clinical uses of the NSAIDs?






9. What microorganisms is Aztreonam not effective against?






10. Aztreonam is not usually...






11. Name three Antiarrhythmic drugs in class IV.






12. What class of drug is echothiophate? What is its indication?






13. Which cancer drugs work at the level of mRNA(2)?






14. Furosemide - toxicity? (OH DANG)






15. How does NE modulate its own release? What other neurotransmitter has this same effect?






16. What are the side effects of Rifampin?






17. ADH antagonists - site of action?






18. Name common Polymyxins






19. Which of epi - norepi - or isoproterenol results in bradycardia?






20. Foscarnet toxicity?






21. What are four H2 Blockers?






22. List the mechanism - clinical use - & toxicity of Bleomycin.






23. Where does Griseofulvin deposit?






24. Which drug(s) cause this reaction: Hot flashes?






25. How is Acyclovir used clinically?






26. What are two conditions in Which COX-2 inhibitors might be used?






27. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






28. What is the mechanism of action of Sildenafil (Viagra)?






29. How are Sulfonamides employed clinically?






30. What is the mechanism of action of Clomiphene?






31. Side effects of Isoniazid (INH)?






32. Which H2 Blocker has the most toxic effects and What are they?






33. What is the difference in receptor affinity of epinephrine at low doses? High doses?

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34. What is the mechanism of Leuprolide?






35. What is the formula for Volume of distribution (Vd)






36. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






37. Why does NE result in bradycardia?






38. What is the lab value used to monitor the effectiveness of Warfarin therapy?






39. Which cancer drugs effect nuclear DNA (4)?






40. Which drug(s) cause this reaction: Cutaneous flushing (4)?






41. What is the mechanism of action of Mifepristone (RU486)?






42. Thiazides - site of action?






43. Which drug(s) cause this reaction: SLE- like syndrome?






44. Which drug(s) cause this reaction: Agranulocytosis (3)?






45. How does a competitive antagonist effect an agonist?






46. Adverse effects of Loop Diuretics?






47. What is the category of drug names ending in - oxin (e.g. Digoxin)






48. Antiarrhythmic class II- toxicity?






49. What is the category and mechanism of action of Zileuton in Asthma treatment?






50. List the mechanism - clinical use - & toxicity of Methotrexate.