Test your basic knowledge |

USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. List the mechanism - clinical use - & toxicity of Paclitaxel.






2. What is the formula for Clearance (CL)






3. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






4. What are common toxicities associated with Tetracyclines?

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5. Nifedipine has similar action to?






6. Which drug(s) cause this reaction: Atropine - like side effects?






7. What is the clinical use of Mifepristone (RU486)?






8. Aztreonam ________ to penicillinase






9. Which receptors does phenylephrine act upon?






10. Which drug(s) cause this reaction: Torsade de pointes (2)?






11. Resistance mechanisms for Tetracycline






12. What is the difference in receptor affinity of epinephrine at low doses? High doses?

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13. Which cancer drugs work at the level of mRNA(2)?






14. What are four thrombolytics?






15. What are two conditions in Which COX-2 inhibitors might be used?






16. What are the clinical uses for 3rd Generation Cephalosporins?






17. IV Penicillin






18. How do Sulfonamides act on bacteria?






19. MOA: Block peptidoglycan synthesis






20. For Warfarin What is the Duration of action






21. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






22. Name the common Azoles






23. What effect would atropine have on a patient with peptic ulcer disease?






24. What is the clinical utility of cocaine?






25. Would blockade of muscarininc receptors in the bladder be useful in treating urinary retention?






26. What is the category - method of use - and adverse effects of Salmeterol in Asthma treatment?






27. What is the effect of guanethidine on adrenergic NE release?






28. List the specific antidote for this toxin: Carbon monoxide






29. List the specific antidote for this toxin: Salicylates






30. Digoxin v. Digitoxin: half life?






31. What organisms does Griseofulvin target?






32. Are penicillinase resistant






33. What is the memory key for Metronidazole's clinical uses?






34. What is the mechanism of Azathioprine?






35. What are the major toxic side effects of Imipenem/cilastatin?






36. What is the clinical use for Nystatin?






37. What are common serious side effects of Aminoglycosides and What are these associated with?






38. List the specific antidote for this toxin: Tricyclic antidepressants






39. What is Fluconazole specifically used for?






40. What are common toxic side effects of Sulfonamides? (5)






41. What is the clinical use for Warfarin?






42. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






43. What is the MOA of Isoniazid (INH)?






44. Foscarnet toxicity?






45. What type of gout is treated with Colchicine?






46. What are the clinical indications for Azole therapy?






47. How is Ganciclovir used clinically?






48. What is treated with Chloroquine - Quinine - Mefloquine?






49. What is the category of drug names ending in - ane (e.g. Halothane)






50. Mannitol - mechanism?