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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How does NE modulate its own release? What other neurotransmitter has this same effect?






2. What cholinergic inhibitor acts by directly inhibiting Ach release at the presynaptic terminal






3. Toxic side effects of the Azoles?






4. Aztreonam is not ________ with penicillins






5. Isopoterenol was given to a patient with a developing AV block - why?






6. What are three clinical uses of the Leuprolide?






7. Ganciclovir associated toxicities?






8. Name several common Macrolides (3)






9. Which diuretics cause alkalosis?






10. K+ sparing diuretics - toxicity?






11. List the specific antidote for this toxin: Digitalis






12. What is a common side effect of Misoprostol?






13. What is the mechanism of action of Heparin?






14. Procainamide - toxicity?






15. For Warfarin What is the Treatment for overdose






16. What is the MOA of Ganciclovir?






17. Which drug(s) cause this reaction: Tardive dyskinesia?






18. What is the mechanism of action of the thrombolytics?






19. If a patient is given hexamethonium - What would happen to his/her heart rate?






20. What are the side effects of Rifampin?






21. List the specific antidote for this toxin: Iron






22. MOA of Succinylcholine






23. List the mechanism - clinical use - & toxicity of Cisplatin.






24. List the mechanism - clinical use - & toxicity of Bleomycin.






25. How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax - P.ovale) treated?






26. Ca2+ channel blockers - clinical use?






27. What sympathomimetic would you not prescribe for hypotension in a pt with renal artery sclerosis.






28. What is the memory key for Metronidazole's clinical uses?






29. What is clinical use for Carbenicillin - Piperacillin - and Ticarcillin?






30. How would you reverse the effect of a neuromuscular blocking agent?






31. Common toxicities associated with Fluoroquinolones?






32. Name the common Aminoglycosides (5)






33. For Heparin What is the Structure






34. Common toxicities associated with Griseofulvin?






35. What musculo - skeletal side effects in Adults are associated with Floroquinolones?






36. Beta Blockers - site of action?






37. Antiarrhythmic class IB- clinical uses?






38. What is Clindamycin used for clinically?






39. How are Sulfonamides employed clinically?






40. What are the phases of succinylcholine neuromuscular blockade?






41. What is the category of drug names ending in - oxin (e.g. Digoxin)






42. How is Amphotericin B used clinically?






43. Antimicrobial prophylaxis for a history of recurrent UTIs






44. What are Amantadine - associated side effects?






45. How is Vancomycin used clinically?






46. Which drug(s) cause this reaction: Cardiac toxicity?






47. How is Ganciclovir used clinically?






48. What is combination TMP- SMZ used to treat?






49. Why would you give a drug like pancuronium or succinylcholine?






50. Which drug(s) cause this reaction: Anaphylaxis?






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