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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name several common Macrolides (3)






2. What is the receptor affinity and clinical use of isoproterenol?






3. What is the memory key for the action of Sildenafil (Viagra)?






4. What is the MOA of Polymyxins?






5. What are the major structural differences between Penicillin and Cephalosporin?






6. What is the mechanism of action of Aspirin?






7. Steady state concentration is reached in __ number of half - lifes






8. Hydrochlorothiazide - mechanism?






9. What are toxic side effects for Metronidazole?






10. What is the mechanism of action of the Alpha - glucosidase inhibitors?






11. Clinical use of Isoniazid (INH)?






12. Name two LPL stimulators.






13. List the specific antidote for this toxin: Methemoglobin






14. Cocaine casues vasoconstriction and local anesthesia by What mechanism






15. What is a mnemonic to remember Amantadine's function?






16. What parasites are treated with Pyrantel Pamoate (more specific)?






17. Toxic effects of TMP include?






18. What are common side effects of RT Inhibitors?






19. What is the category of drug names ending in - terol (e.g. Albuterol)






20. List the mechanism - clinical use - & toxicity of Vincristine.

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21. What are five advantages of Oral Contraceptives (synthetic progestins - estrogen)?






22. How is Ribavirin used clinically?






23. Which drug(s) cause this reaction: Hepatitis?






24. If a patient is given hexamethonium - What would happen to his/her heart rate?






25. ACE inhibitors - toxicity?






26. What is the mechanism of action of Cyclosporine?






27. Which diuretics increase urine K+?






28. Which drug(s) cause this reaction: Cardiac toxicity?






29. Which drug(s) cause this reaction: Adrenocortical Insufficiency






30. Adverse effects of Clonidine?






31. What is the formula for Clearance (CL)






32. What are two processes Corticosteroids inhibit leading to decreased inflammation?






33. Resistance mechanisms for Vancomycin






34. What is the mechanism of action of Misoprostol?






35. How is Vancomycin used clinically?






36. List the specific antidote for this toxin: Warfarin






37. Mannitol - mechanism?






38. What enzyme does Zileuton inhibit?






39. List the specific antidote for this toxin: Anticholinesterases (organophosphate.)






40. What type of gout is treated with Probenacid?






41. List the specific antidote for this toxin: Beta Blockers






42. List the mechanism - clinical use - & toxicity of 6 MP.






43. Which drug(s) cause this reaction: Thrombotic complications?






44. Which Tetracycline is used in patients with renal failure? / Why?






45. What organisms does Griseofulvin target?






46. Which drug(s) cause this reaction: Agranulocytosis (3)?






47. Which individuals are predisposed to Sulfonamide - induced hemolysis?






48. What are common toxicities associated with Tetracyclines?

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49. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






50. What are the clinical indications for bethanechol?