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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. A 57 yo heart failure pt develops cardiac decompensation - What drug will give you adequate perfusion of his kidneys as well as tx for his Hypotension






2. Secretion of What drug is inhibited by Probenacid used to treat chronic gout?






3. What are five possible toxic effects of Aspirin therapy?

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4. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






5. List the mechanism - clinical use - & toxicity of Busulfan.






6. What is the MOA for the Tetracyclines?






7. List the specific antidote for this toxin: Acetaminophen






8. Beta Blockers - BP?






9. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






10. List the specific antidote for this toxin: Cyanide






11. Steady state concentration is reached in __ number of half - lifes






12. What parasitic condition is treated with Ivermectin?

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13. Ca2+ channel blockers - clinical use?






14. For Heparin What is the Site of action






15. What is the MOA of Foscarnet?






16. What is the effect of the Glitazones in diabetes treatment?






17. Beta Blockers - CV toxicity?






18. ___________ are Teratogenic






19. Isopoterenol was given to a patient with a developing AV block - why?






20. What is the MOA for Trimethoprim (TMP)?






21. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






22. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






23. What is the MOA for Amphotericin B?






24. What parasites are treated with Pyrantel Pamoate (more specific)?






25. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






26. Name three Antiarrhythmic drugs in class IV.






27. List the specific antidote for this toxin: Beta Blockers






28. What is the MOA for Metronidazole?






29. What conditions would you use dantrolene?






30. Sotalol - toxicity?






31. Acetaminophen has What two clinical uses and lacks What one clinical use of the NSAIDs?






32. What are common toxic side effects of Sulfonamides? (5)






33. Which drug(s) cause this reaction: Tendonitis and rupture?






34. How do spare receptors effect the Km?






35. Name some common Tetracyclines (4)






36. List the specific antidote for this toxin: TPA & Streptokinase






37. Resistance mechanisms for Vancomycin






38. Hydralazine - class and mechanism?






39. What are four clinical uses of glucocorticoids?

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40. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






41. Ibutilide - toxicity?






42. Does Ampicillin or Amoxicillin have a greater oral bioavailability?






43. Decrease Digoxin dose in renal failure?






44. Which Tetracycline is used in patients with renal failure? / Why?






45. In What population does Gray Baby Syndrome occur? Why?






46. What are four thrombolytics?






47. What is the category of drug names ending in - operidol (e.g. Haloperidol)






48. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






49. Side effects of Isoniazid (INH)?






50. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?







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