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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are two types of drugs that interfere with the action of Sucralfate and why?






2. What is the MOA for Clindamycin?






3. Antiarrhythmic class IB- effects?






4. Foscarnet toxicity?






5. What are the classic symptoms of cholinesterase inhibitor poisoning (parathion or other organophosphates)?






6. What side effect of using atropine to induce pupillary dilation would you expect?






7. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






8. Which H2 Blocker has the most toxic effects and What are they?






9. Ryanodine - site of action?






10. Explain potency in relation to full and partial agonists(2).






11. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






12. Beta Blockers - CV toxicity?






13. Side effects of Isoniazid (INH)?






14. Adverse effect of Nitroprusside?






15. In What population does Gray Baby Syndrome occur? Why?






16. Which of epi - norepi - or isoproterenol results in bradycardia?






17. What is the MOA for the Tetracyclines?






18. What are toxic side effects for Metronidazole?






19. What is the category of drug names ending in - tidine (e.g. Cimetidine)






20. What is the mechanism of action of Heparin?






21. What is the major side effect for Ampicillin and Amoxicillin?






22. What is the mechanism of action of Mifepristone (RU486)?






23. Acetazolamide - clinical uses?






24. Name the steps in drug approval(4)?






25. How do the Protease Inhibitors work?






26. What microorganisms are clinical indications for Tetracycline therapy?

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27. What is an additional side effect of Methicillin?






28. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






29. What are the clinical uses for Aztreonam?






30. Hydrochlorothiazide - toxicity? (hyperGLUC - plus others)






31. What physiological effects was the Anes using Atropine to tx






32. Name three Antiarrhythmic drugs in class IC.






33. How would you treat African Trypanosomiasis (sleeping sickness)?






34. Name two classes of drugs for HIV therapy






35. What drug is used during the pregnancy of an HIV+ mother? - Why?






36. Can Warfarin be used during pregnancy?






37. What are three toxicities of Leuprolied?






38. What is the category of drug names ending in - azine (e.g. Chlorpromazine)






39. Why is Cilastatin administered with Imipenem?






40. Verapamil has similar action to?






41. Which drug(s) cause this reaction: Stevens - Johnson syn. (3)?






42. What is the mechanism of action of Misoprostol?






43. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






44. Furosemide increases the excretion of What ion?






45. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






46. What anticholinesterase crosses the blood - brain - barrier?






47. What is the mechanism of action of the Alpha - glucosidase inhibitors?






48. List some specifics of lead poisoning(4)?






49. What is the mechanism of action of Aspirin?






50. Which drug(s) cause this reaction: Thrombotic complications?