Test your basic knowledge |

USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How does Ganciclovir's toxicity relate to that of Acyclovir?






2. What is Imipenem always administered with?






3. What is a common drug interaction associated with Griseofulvin?






4. How do spare receptors effect the Km?






5. List the mechanism - clinical use - & toxicity of Tamoxifen.






6. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






7. What is the mechanism of action of Misoprostol?






8. Hydralazine - clinical use?






9. Which drug(s) cause this reaction: Cardiac toxicity?






10. Which drug(s) cause this reaction: G6PD hemolysis(8)?






11. What is the mecanism of action of Sucralfate?






12. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






13. What are two types of drugs that interfere with the action of Sucralfate and why?






14. What is the mechanism of action of NSAIDs other than Aspirin?






15. Which drug(s) cause this reaction: Fanconi's syndrome?






16. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






17. How is Amphotericin B used clinically?






18. What is the major side effect for Ampicillin and Amoxicillin?






19. MOA: Block protein synthesis at 50s subunit






20. Name three calcium channel blockers?






21. What is the memory key for the effect of aluminum hydroxide overuse?






22. Which cancer drugs inhibit nucleotide synthesis(3)?






23. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






24. Name the common Nucleoside Reverse Transcriptase Inhibitors






25. What antimuscarinic agent is used in asthma and COPD?






26. Antiarrhythmic class IC- effects?






27. Resistance mechanisms for Aminoglycosides






28. How is Ganciclovir used clinically?






29. Which Aminoglycoside is used for Bowel Surgery ?






30. How do Sulfonamides act on bacteria?






31. How does angiotensin II affect NE release?






32. A group of pts are rushed into the ER complaining of excessive sweating - tearing - salivation - HA - N and V - muscle twitching - difficulty breathing and diarrhea. What drug would be the most effective immediate tx






33. List the specific antidote for this toxin: Acetaminophen






34. What is the category of drug names ending in - ane (e.g. Halothane)






35. What are three toxicities of Leuprolied?






36. MOA: Block nucleotide synthesis






37. How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax - P.ovale) treated?






38. While at a tail gait party - you bite into a sandwich that a yellow jacket is also enjoying. Knowing your allergy to this creature - What should you do?






39. How is Griseofulvin used clinically?






40. Foscarnet does not require activation by a...






41. Resistance mechanisms for Vancomycin






42. What are the clinical indications for Azole therapy?






43. Which drug(s) cause this reaction: Aplastic anemia (5)?






44. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






45. List the mechanism - clinical use - & toxicity of Paclitaxel.






46. Are penicillinase resistant






47. Antiarrhythmic class IC- toxicity?






48. What effect would atropine have on the preganglionic sympathetic activation of sweat glands? Would this person sweat?






49. Antiarrhythmic class IA effects?






50. Name three ACE inhibitors?