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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name three ACE inhibitors?






2. What are three clinical uses of the NSAIDs?






3. Adverse effects of ganglionic blockers?






4. What is the mechanism of action of Misoprostol?






5. What is used to reverse the action of Heparin?






6. Ibutilide - toxicity?






7. How is Rifampin used clinically?






8. What are the clinical indications for neostigmine?






9. List the specific antidote for this toxin: Cyanide






10. Can Warfarin be used during pregnancy?






11. What is the mechanism of action of the glucocorticoids?






12. What is the category of drug names ending in - triptyline (e.g. Amitriptyline)






13. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






14. Digoxin v. Digitoxin: protein binding?






15. How do the Protease Inhibitors work?






16. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






17. K+ sparing diuretics - site of action?






18. What is the category and mechanism of action of Zafirlukast in Asthma treatment?






19. ACE inhibitors - mechanism?






20. Name five Antiarrhythmic drugs in class II?






21. For Warfarin What is the Duration of action






22. Which diuretics increase urine NaCl?






23. What is the MOA for Methicillin - Nafcillin - and Dicloxacillin?






24. What is the mechanism of action and clinical use of the antiandrogens Ketoconazole and Spironolactone?






25. Adverse effects of Clonidine?






26. Acetazolamide - site of action?






27. How can the toxic effects of TMP be ameliorated?






28. What is the memory key for the action of Sildenafil (Viagra)?






29. Common toxicities associated with Fluoroquinolones?






30. ACE inhibitors - toxicity?






31. How would you treat African Trypanosomiasis (sleeping sickness)?






32. For Heparin What is the Duration of action






33. Which diuretics increase urine Ca2+?






34. Antiarrhythmic class IC- effects?






35. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






36. List the specific antidote for this toxin: Heparin






37. What antimicrobial class is Aztreonam syngergestic with?






38. What is the clincial use for Misoprostol?






39. MOA of Succinylcholine






40. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






41. Furosemide - clinical use?






42. MOA: Block protein synthesis at 30s subunit






43. List the mechanism - clinical use - & toxicity of Prednisone.

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44. What are Fluoroquinolones indicated for? (3)






45. Antiarrhythmic class IV- toxicity?






46. Procainamide - toxicity?






47. Isopoterenol was given to a patient with a developing AV block - why?






48. Which drug(s) cause this reaction: Oto and Nephrotoxicity (3)?






49. Adverse effects of Captopril?






50. Explain potency in relation to full and partial agonists(2).