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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. List the specific antidote for this toxin: Heparin






2. Esmolol - short or long acting?






3. What is the mechanism of Leuprolide?






4. What are four advantages of newer low - molecular - weight heparins (Enoxaparin)?






5. What is the MOA of Griseofulvin?






6. What are two mechanisms of action of Propythiouracil?






7. Beta Blockers - CNS toxicity?






8. Explain potency in relation to full and partial agonists(2).






9. What is the mechanism of action of Warfarin (Coumadin)?






10. What is the mechanism of action of Clomiphene?






11. Explain differences between full and partial agonists(2).






12. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






13. Aztreonam ________ to penicillinase






14. What are two Glitazones?






15. Ca2+ channel blockers - clinical use?






16. What drug is used to diagnose myasthenia gravis?






17. Name three Antiarrhythmic drugs in class IV.






18. Describe Phase II metabolism in liver(3)?






19. How does Ganciclovir's toxicity relate to that of Acyclovir?






20. For Warfarin What is the Mechanism of action






21. Resistance mechanisms for Tetracycline






22. Digoxin v. Digitoxin: protein binding?






23. What is the category of drug names ending in - operidol (e.g. Haloperidol)






24. Name five Antiarrhythmic drugs in class II?






25. What are four thrombolytics?






26. What sympathomimetic would you not prescribe for hypotension in a pt with renal artery sclerosis.






27. What is the category of drug names ending in - azepam (e.g. Diazepam)






28. Describe Phase I metabolism in liver(3)?






29. What parasites are treated with Pyrantel Pamoate (more specific)?






30. What is the memory key for organisms treated with Tetracyclines?

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31. What microorganisms is Aztreonam not effective against?






32. Can Warfarin be used during pregnancy?






33. Mannitol - clinical use?






34. What are three possible toxicities of NSAID usage?






35. For Warfarin What is the Route of administration






36. List the mechanism - clinical use - & toxicity of 6 MP.






37. Is resistant to penicillinase?






38. Reserpine will block the syntheis of this drug and but not its precursor.






39. Adverse effects of Methyldopa?

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40. Digoxin v. Digitoxin: half life?






41. Describe first - order kinetics?






42. What are three toxicities of Propylthiouracil?






43. Digitalis - site of action?






44. What is the MOA of Ganciclovir?






45. For Heparin What is the Lab value to monitor






46. Which drug(s) cause this reaction: Thrombotic complications?






47. Which drug(s) cause this reaction: Cutaneous flushing (4)?






48. Toxicities associated with Acyclovir?






49. What is an additional side effect of Methicillin?






50. What is the mechanism of action of Omeprazole - Lansoprazole?