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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Ethacrynic Acid - toxicity?






2. Resistance mechanisms for Aminoglycosides






3. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






4. What are the major toxic side effects of the Cephalosporins?






5. MOA: Disrupt fungal cell membranes






6. List the mechanism - clinical use - & toxicity of Nitrosureas.






7. How is Rifampin used clinically?






8. Hydralazine - class and mechanism?






9. What is the MOA for Rifampin?






10. List the specific antidote for this toxin: Lead






11. What is the MOA for the Tetracyclines?






12. MOA: Bactericidal antibiotics






13. What is the mechanism of action of the glucocorticoids?






14. List the mechanism - clinical use - & toxicity of 6 MP.






15. Beta Blockers - CNS toxicity?






16. Which drug(s) cause this reaction: Fanconi's syndrome?






17. How is Griseofulvin used clinically?






18. Which of epi - norepi - or isoproterenol results in bradycardia?






19. Common toxicities associated with Fluoroquinolones?






20. What is the mechanism of action of the Sulfonylureas?






21. Antiarrhythmic class IV- effects?






22. Which antimicrobial classes inhibit protein synthesis at the 30S subunit? (2)






23. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






24. List the specific antidote for this toxin: Benzodiazepines






25. List the specific antidote for this toxin: Carbon monoxide






26. List the mechanism - clinical use - & toxicity of Paclitaxel.






27. What is a prerequisite for Acyclovir activation?






28. What are three complications of Warfarin usage?






29. How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax - P.ovale) treated?






30. How is Acyclovir used clinically?






31. Is resistant to penicillinase?






32. What is the category of drug names ending in - azepam (e.g. Diazepam)






33. What is the mechanism of action of Acetaminophen?






34. Which diuretics cause alkalosis?






35. Adverse effects of Nifedipine - verapamil?






36. How does NE modulate its own release? What other neurotransmitter has this same effect?






37. How do you calculate maintenance dose?






38. How is Ribavirin used clinically?






39. Why are Methicillin - Nafcillin - and Dicloxacillin penicillinase resistant?






40. List the mechanism - clinical use - & toxicity of Vincristine.

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41. Ibutilide - toxicity?






42. K+ sparing diuretics - site of action?






43. Name the common Aminoglycosides (5)






44. Which diuretics increase urine NaCl?






45. What should not be taken with Tetracyclines? / Why?






46. MOA: Block protein synthesis at 30s subunit






47. What is the most common cause of Pt noncompliance with Macrolides?






48. Which cancer drugs inhibit nucleotide synthesis(3)?






49. ACE inhibitors - toxicity?






50. What are five possible toxic effects of Aspirin therapy?

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