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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What populations are Floroquinolones contraindicated in? Why?






2. How does NE modulate its own release? What other neurotransmitter has this same effect?






3. For Warfarin What is the Ability to inhibit coagulation in vitro






4. What is a sign of toxicity with the use of thrombolytics?






5. Adverse effects of Hydralazine?






6. For Heparin What is the Duration of action






7. What are four H2 Blockers?






8. What enzyme does Zileuton inhibit?






9. Acetazolamide - site of action?






10. What is the effect of the Glitazones in diabetes treatment?






11. Which drug(s) cause this reaction: Atropine - like side effects?






12. In coma situations you rule out What (7)?

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13. What is Imipenem always administered with?






14. What process does Zafirlukast interfere with?






15. What is the category of drug names ending in - zosin (e.g. Prazosin)






16. What is the lab value used to monitor the effectiveness of Warfarin therapy?






17. Amprotericin B ___________ the BBB






18. Foscarnet toxicity?






19. Secretion of What drug is inhibited by Probenacid used to treat chronic gout?






20. Furosemide - class and mechanism?






21. MOA of Succinylcholine






22. What is the category of drug names ending in - oxin (e.g. Digoxin)






23. When is Rifampin not used in combination with other drugs?






24. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






25. ADH antagonists - site of action?






26. Furosemide - toxicity? (OH DANG)






27. How is Vancomycin used clinically?






28. MOA for Penicillin (3 answers)?






29. What are Polymyxins used for?






30. Which diuretics cause alkalosis?






31. What are common serious side effects of Aminoglycosides and What are these associated with?






32. What is the MOA of Ganciclovir?






33. How is Ganciclovir used clinically?






34. What are four thrombolytics?






35. What is the difference between the affinity for beta receptors between albuterol/terbutaline and dantroline?






36. What is the effect of guanethidine on adrenergic NE release?






37. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






38. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






39. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






40. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






41. What are common side effects of RT Inhibitors?






42. What are three clinical uses of the Leuprolide?






43. What are four clinical activities of Aspirin?






44. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






45. Name three Antiarrhythmic drugs in class IV.






46. What are the side effects of Polymyxins?






47. How is Amphotericin B administered for fungal meningitis?






48. How is Chloramphenical used clinically?






49. What is the MOA for the Fluoroquinolones?






50. What is the mechanism of action of Allopurinol used to treat chronic gout?