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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. List the mechanism - clinical use - & toxicity of Etoposide.






2. Name the common Non - Nucleoside Reverse Transcriptase Inhibitors






3. List the specific antidote for this toxin: Opioids






4. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






5. Your patient wants an effective drug to treat his motion sickness - What would you prescribe






6. MOA: Block mRNA synthesis






7. What is the MOA of Ribavirin?






8. How are Sulfonamides employed clinically?






9. Name common Polymyxins






10. Which diuretics cause acidosis?






11. Is resistant to penicillinase?






12. What type of neurological blockade would hexamethonium create?






13. What is are two clinical uses of Cyclosporine?






14. What is the clinical use for Nystatin?






15. How does resistance to Vancomycin occur?






16. What process does Zafirlukast interfere with?






17. What are three toxicities of Propylthiouracil?






18. What type of gout is treated with Probenacid?






19. Describe the MOA of Interferons (INF)






20. When is HIV therapy initiated?






21. Triamterene and amiloride - mechanism?






22. A common side effects of Interferon (INF) treatment is?






23. Acetazolamide - toxicity?






24. What is the mechanism of action of Heparin?






25. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






26. Can Heparin be used during pregnancy?






27. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






28. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






29. What is Niclosamide used for?






30. What are four unwanted effects of Clomiphene use?






31. What are toxic side effects for Metronidazole?






32. ACE inhibitors - toxicity?






33. Which receptors does phenylephrine act upon?






34. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






35. Are not penicillinase resistant






36. Which drug(s) cause this reaction: Aplastic anemia (5)?






37. What enzyme does Zileuton inhibit?






38. Hydralazine - clinical use?






39. Resistance mechanisms for Chloramphenicol






40. List the mechanism - clinical use - & toxicity of Busulfan.






41. What is the memory key for the action of Sildenafil (Viagra)?






42. Beta Blockers - CV toxicity?






43. For Warfarin What is the Treatment for overdose






44. What is the effect of epinephrine infusion on bp and pulse pressure?






45. What is the clinical use for Clomiphene?






46. Name four Antiarrhythmic drugs in class III.






47. Describe first - order kinetics?






48. What is the MOA for Acyclovir?






49. What is a common side effect of Colchicine used to treat acute gout - especially When given orally?






50. List five common glucocorticoids.







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