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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






2. Antiarrhythmic class IB- toxicity?






3. Name the Protease Inhibitors (4)






4. What is the memory key for Isoniazid (INH) toxicity?






5. Classes of antihypertensive drugs?






6. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






7. MOA for Penicillin (3 answers)?






8. What is the mechanism of action of Omeprazole - Lansoprazole?






9. What is the category of drug names ending in - caine (e.g. Lidocaine)






10. Which drug(s) cause this reaction: Tendonitis and rupture?






11. How does botulinum toxin result in respiratory arrest?






12. Why would dopamine be useful in treating shock?






13. What are common side effects of Amphotericin B?






14. What are the side effects of Rifampin?






15. What organism is Imipenem/cilastatin the Drug of Choice for?






16. What is the mechanism of action of NSAIDs other than Aspirin?






17. Side effects of Isoniazid (INH)?






18. For Heparin What is the Onset of action






19. What is used to reverse the action of Heparin?






20. MOA: Block peptidoglycan synthesis






21. Mannitol - clinical use?






22. What is Clindamycin used for clinically?






23. MOA: Block DNA topoisomerases






24. Amprotericin B ___________ the BBB






25. How are Interferons (INF) used clinically?

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26. List the mechanism - clinical use - & toxicity of Paclitaxel.






27. Which drug(s) cause this reaction: Focal to massive hepatic necrosis (4)?






28. Adverse effects of Captopril?






29. Which drug(s) cause this reaction: Photosensitivity(3)?






30. Which drug(s) cause this reaction: Hepatitis?






31. What is the mechanism of action of Misoprostol?






32. Would blockade of muscarininc receptors in the bladder be useful in treating urinary retention?






33. Foscarnet does not require activation by a...






34. What is the MOA for Vancomycin?






35. Which cancer drugs work at the level of mRNA(2)?






36. What are five advantages of Oral Contraceptives (synthetic progestins - estrogen)?






37. What is the mechanism of action of Warfarin (Coumadin)?






38. How do we stop angina?






39. What is the loading dose formula?






40. For Warfarin What is the Onset of action






41. What are common toxicities associated with Macrolides? (4)






42. What is the mechanism of action of Mifepristone (RU486)?






43. What are four conditions in Which H2 Blockers are used clinically?






44. What is the category and mechanism of action of Zafirlukast in Asthma treatment?






45. Adverse effects of Losartan?






46. What is the category of drug names ending in - tidine (e.g. Cimetidine)






47. Which drug(s) cause this reaction: P450 induction(6)?






48. Name some common Tetracyclines (4)






49. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






50. Can Warfarin be used during pregnancy?







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