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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the formula for Clearance (CL)






2. Which drug(s) cause this reaction: Hepatitis?






3. What is the MOA for the Cephalosporins?






4. Are penicillinase resistant






5. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






6. Adverse effects of Captopril?






7. Antimicrobial prophylaxis for Meningococcal infection






8. Name two LPL stimulators.






9. Mg+- clinical use?






10. Resistance mechanisms for Sulfonamides






11. Why are the Sulfonylureas inactive in IDDM (type -1)?






12. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






13. How do you treat coma in the ER (4)?






14. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






15. Antiarrhythmic class IB- toxicity?






16. Toxicities associated with Acyclovir?






17. How is Trimethoprim used clinically?






18. Which cancer drugs work at the level of proteins(2)?






19. What are three unwanted effects of Mifepristone?






20. Name some common Sulfonamides (4)






21. Adverse effects of Nifedipine - verapamil?






22. What is the MOA of Polymyxins?






23. What are two toxicities of the Glitazones?






24. List the mechanism - clinical use - & toxicity of 6 MP.






25. What is the difference in receptor affinity of epinephrine at low doses? High doses?

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26. What do Aminoglycosides require for uptake?






27. List the specific antidote for this toxin: Digitalis






28. What Sulfonamides are used for simple UTIs?






29. As an Anes you want to use a depolarizing neuromuscular blocking drug on your pt - What do you use






30. What antimicrobial class is Aztreonam syngergestic with?






31. What is the MOA for Nystatin?






32. Name several common Macrolides (3)






33. Name some common Tetracyclines (4)






34. Which receptors does phenylephrine act upon?






35. Explain differences between full and partial agonists(2).






36. How does a noncompetitive antagonist effect an agonist?






37. What is the MOA for Rifampin?






38. Ca2+ channel blockers - site of action?






39. What are the clinical uses for 1st Generation Cephalosporins?






40. What reversal agent could a Anes give to reverse the effects of Atropine






41. How does angiotensin II affect NE release?






42. What populations are Floroquinolones contraindicated in? Why?






43. Resistance mechanisms for Cephalosporins/Penicillins






44. How is Amphotericin B used clinically?






45. Digoxin v. Digitoxin: bioavailability?






46. What is the category of drug names ending in - navir (e.g. Saquinavir)






47. Which diuretics cause alkalosis?






48. What is the receptor affinity and clinical use of isoproterenol?






49. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






50. ACE inhibitors - clinical use?