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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the category of drug names ending in - operidol (e.g. Haloperidol)






2. Name three K+ sparing diuretics?






3. What are three types of antacids and the problems that can result from their overuse?






4. How do Sulfonamides act on bacteria?






5. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






6. Ca2+ channel blockers - toxicity?






7. Which drug(s) cause this reaction: Adrenocortical Insufficiency






8. What are five toxicities associated with Tacrolimus (FK506)?






9. What is the MOA for the Aminoglycosides?






10. Describe the MOA of Interferons (INF)






11. What is the effect of epinephrine infusion on bp and pulse pressure?






12. What are three toxicities of Propylthiouracil?






13. What is the mechanism of action of the Sulfonylureas?






14. How is Rifampin used clinically?






15. Nifedipine has similar action to?






16. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






17. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






18. MOA for Penicillin (3 answers)?






19. What are Amantadine - associated side effects?






20. Aztreonam is not usually...






21. What is the mechanism of action of Sildenafil (Viagra)?






22. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






23. What is the MOA of Isoniazid (INH)?






24. What are the classic symptoms of cholinesterase inhibitor poisoning (parathion or other organophosphates)?






25. Ethacrynic Acid - mechanism?






26. What organism is Imipenem/cilastatin the Drug of Choice for?






27. What is the difference between the affinity for beta receptors between albuterol/terbutaline and dantroline?






28. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






29. Are not penicillinase resistant






30. What organisms does Griseofulvin target?






31. What are the products and their toxicities of the metabolism of Ethylene Glycol by / alcohol dehydrogenase?






32. Ethacrynic Acid - clinical use?






33. What is Metronidazole used for clinically?






34. Quinidine - toxicity?






35. List the mechanism - clinical use - & toxicity of Prednisone.

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36. What is the mechanism of action of the H2 Blockers?






37. What neurotransmitter does Amantadine affect? How does it influence this NT?






38. Which drug(s) cause this reaction: Aplastic anemia (5)?






39. Antiarrhythmic class IV- primary site of action?






40. Which drug(s) cause this reaction: Pseudomembranous colitis?






41. Antiarrhythmic class IA effects?






42. Where does Griseofulvin deposit?






43. Ethacrynic Acid - toxicity?






44. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






45. What are the products and their toxicities of the metabolism of ethanol by / alcohol dehydrogenase?






46. Reserpine will block the syntheis of this drug and but not its precursor.






47. Esmolol - short or long acting?






48. List the specific antidote for this toxin: Carbon monoxide






49. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?






50. What is the mechanism of Tacrolimus (FK506)?







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