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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Adverse effects of Nifedipine - verapamil?






2. What is the mechanism of Leuprolide?






3. What is the clinical use of Mifepristone (RU486)?






4. Procainamide - toxicity?






5. Name three K+ sparing diuretics?






6. Do Tetracyclines penetrate the CNS?






7. What is the mechanism of action of Acetaminophen?






8. List the specific antidote for this toxin: Amphetamine






9. What is the category - desired effect - and adverse effect of Isoproterenol in the treatment of Asthma?






10. What drug is used to diagnose myasthenia gravis?






11. What is the only depolarizing neuromuscular blocking agent?






12. IV Penicillin






13. What is the receptor affinity and clinical use of isoproterenol?






14. What is the effect of TCA's on the adrenergic nerve?






15. What are two toxicities of the Sulfonylureas?






16. What is the major toxic side effect of Penicillin?






17. List five common glucocorticoids.






18. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






19. For Heparin What is the Treatment for overdose






20. What is Imipenem always administered with?






21. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






22. Explain potency in relation to full and partial agonists(2).






23. Are Ampicillin and Amoxicillin are not...






24. Furosemide - class and mechanism?






25. Which individuals are predisposed to Sulfonamide - induced hemolysis?






26. List the mechanism - clinical use - & toxicity of Busulfan.






27. What physiological effects was the Anes using Atropine to tx






28. How does botulinum toxin result in respiratory arrest?






29. What is the clinical use for Nystatin?






30. Which Tetracycline is used in patients with renal failure? / Why?






31. What is the mechanism of action of the Sulfonylureas?






32. Beta Blockers - BP?






33. List the specific antidote for this toxin: Carbon monoxide






34. For Warfarin What is the Onset of action






35. Which antimicrobial classes inhibit protein synthesis at the 30S subunit? (2)






36. What process does Zafirlukast interfere with?






37. Acetaminophen has What two clinical uses and lacks What one clinical use of the NSAIDs?






38. What type of patient should not take Misoprostol and why?






39. Name three ACE inhibitors?






40. Which drug(s) cause this reaction: Pseudomembranous colitis?






41. What is the category of drug names ending in - oxin (e.g. Digoxin)






42. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






43. What are Polymyxins used for?






44. What are the products and their toxicities of the metabolism of Ethylene Glycol by / alcohol dehydrogenase?






45. What are the clinical indications for Azole therapy?






46. Name two LPL stimulators.






47. What is the MOA for the Azoles?






48. What are toxic side effects for Metronidazole?






49. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






50. Which cancer drugs inhibit nucleotide synthesis(3)?