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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. List the specific antidote for this toxin: Heparin






2. What is the MOA for the Cephalosporins?






3. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






4. Common toxicities associated with Fluoroquinolones?






5. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






6. Furosemide - clinical use?






7. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






8. Name two LPL stimulators.






9. Spironolactone - mechanism?






10. Adverse effects of Hydralazine?






11. Cautions When using Amiodarone?






12. How is Chloramphenical used clinically?






13. What is the MOA for the Tetracyclines?






14. What effect would atropine have on the preganglionic sympathetic activation of sweat glands? Would this person sweat?






15. Mnemonic for Foscarnet?






16. What are three clinical uses of the NSAIDs?






17. What is the mechanism of action of Clomiphene?






18. Hydralazine - clinical use?






19. What are two types of drugs that interfere with the action of Sucralfate and why?






20. Mannitol - contraindications?






21. Name the common Non - Nucleoside Reverse Transcriptase Inhibitors






22. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






23. MOA of Succinylcholine






24. Ryanodine - site of action?






25. Why does atropine dilate the pupil?






26. Common side effects associated with Clindamycin include?






27. What are the clinical uses for 2nd Generation Cephalosporins?






28. MOA: Disrupt fungal cell membranes






29. What is the clinical use for Nystatin?






30. What populations are Floroquinolones contraindicated in? Why?






31. What is the mechanism of action of Colchicine used to treat acute gout?






32. What are five disadvantages of Oral Contraceptives (synthetic progestins - estrogen)?






33. How are the HIV drugs used clinically?

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34. List the specific antidote for this toxin: Benzodiazepines






35. Describe Phase I metabolism in liver(3)?






36. What is the category of drug names ending in - cillin (e.g. Methicillin)






37. What is the category of drug names ending in - terol (e.g. Albuterol)






38. Adverse effects of Methyldopa?

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39. List the specific antidote for this toxin: Anticholinesterases (organophosphate.)






40. Explain pH dependent urinary drug elimination?






41. How can the t1/2 of INH be altered?






42. What is the category of drug names ending in - caine (e.g. Lidocaine)






43. What is the MOA for Acyclovir?






44. How do spare receptors effect the Km?






45. What are the side effects of Rifampin?






46. Clinical use of Isoniazid (INH)?






47. What are four unwanted effects of Clomiphene use?






48. Which drug(s) cause this reaction: Aplastic anemia (5)?






49. Which drug(s) cause this reaction: Stevens - Johnson syn. (3)?






50. What is the category of drug names ending in - cycline (e.g. Tetracycline)