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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Mannitol - toxicity?






2. Would blockade of muscarininc receptors in the bladder be useful in treating urinary retention?






3. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






4. For Warfarin What is the Duration of action






5. IV Penicillin






6. K+- clinical use?






7. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






8. Adverse effects of Nifedipine - verapamil?






9. What is the memory key for Isoniazid (INH) toxicity?






10. What cholinomimetics might your pt be taking for his glaucoma






11. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






12. Which drug(s) cause this reaction: Cough?






13. How is Griseofulvin used clinically?






14. What can result due to antacid overuse?






15. What conditions are treated with Metronidazole?






16. How does Ganciclovir's toxicity relate to that of Acyclovir?






17. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






18. Guanethidine enhances the release of Norepi?






19. Which drug(s) cause this reaction: Gray baby syndrome?






20. Resistance mechanisms for Vancomycin






21. Adverse effects of Clonidine?






22. What are the major toxic side effects of the Cephalosporins?






23. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






24. Why is carbachol and pilocarpine useful in treatment of glaucoma?






25. List the specific antidote for this toxin: Tricyclic antidepressants






26. What is the difference in receptor affinity of epinephrine at low doses? High doses?


27. What are the phases of succinylcholine neuromuscular blockade?






28. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






29. Describe the MOA of Interferons (INF)






30. What is the category - desired effect - and adverse effect of Isoproterenol in the treatment of Asthma?






31. What is the memory key for Metronidazole's clinical uses?






32. How does NE modulate its own release? What other neurotransmitter has this same effect?






33. Which cancer drugs effect nuclear DNA (4)?






34. For Heparin What is the Treatment for overdose






35. Which antimicrobial classes inhibit protein synthesis at the 30S subunit? (2)






36. Antiarrhythmic class IB- clinical uses?






37. Why is reserpine effective in treating HTN?






38. List the specific antidote for this toxin: Opioids






39. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






40. Antimicrobial prophylaxis for Gonorrhea






41. Which receptors does phenylephrine act upon?






42. Your patient wants an effective drug to treat his motion sickness - What would you prescribe






43. Furosemide - class and mechanism?






44. Which drug(s) cause this reaction: Torsade de pointes (2)?






45. Adverse effects of Methyldopa?


46. Name the common Non - Nucleoside Reverse Transcriptase Inhibitors






47. What is the MOA of the RT Inhibitors?






48. How is Leishmaniasis treated?






49. Decrease Digoxin dose in renal failure?






50. Which drug(s) cause this reaction: Agranulocytosis (3)?