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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which drug(s) cause this reaction: Anaphylaxis?






2. How do spare receptors effect the Km?






3. Which cancer drugs work at the level of mRNA(2)?






4. What is the mechanism of action of Aspirin?






5. What is the chemical name for Ganciclovir?






6. List the specific antidote for this toxin: Tricyclic antidepressants






7. Which drug(s) cause this reaction: Gynecomastia (6)?






8. Steady state concentration is reached in __ number of half - lifes






9. What is the clinical use of Mifepristone (RU486)?






10. What are the nondepolarizing neuromuscular blocking drugs?






11. Preferential action of the Ca2+ channel blockers at cardiac muscle?






12. What type of patient should not take Misoprostol and why?






13. How is Foscarnet used clinically?






14. What is the clinical use for Clomiphene?






15. Which drug(s) cause this reaction: Thrombotic complications?






16. Antiarrhythmic class II- toxicity?






17. What is the category - desired effect - and period of use of albuterol in the treatment of Asthma?






18. What is the MOA of Isoniazid (INH)?






19. Why are the Sulfonylureas inactive in IDDM (type -1)?






20. What neurotransmitter does Amantadine affect? How does it influence this NT?






21. What is the only depolarizing neuromuscular blocking agent?






22. Which drug(s) cause this reaction: Osteoporosis (2)?






23. List the specific antidote for this toxin: Acetaminophen






24. Which drug(s) cause this reaction: Diabetes insipidus?






25. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






26. Why are Methicillin - Nafcillin - and Dicloxacillin penicillinase resistant?






27. Adverse effects of Nifedipine - verapamil?






28. What enzyme does Zileuton inhibit?






29. Ganciclovir associated toxicities?






30. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






31. Name four Antiarrhythmic drugs in class IA.






32. What are the indications for using amphetamine?

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33. Name the common Nucleoside Reverse Transcriptase Inhibitors






34. Furosemide - clinical use?






35. Classes of antihypertensive drugs?






36. The COX-2 inhibitors (celecoxib - rofecoxib) have similar side effects to the NSAIDs with What one exception?






37. Loop diuretics (furosemide)- site of action?






38. ACE inhibitors - mechanism?






39. List the specific antidote for this toxin: Opioids






40. List the specific antidote for this toxin: Methanol & Ethylene glycol






41. MOA: Disrupt bacterial/fungal cell membranes






42. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






43. What drug is given for Pneumocystis carinii prophylaxis?






44. List the specific antidote for this toxin: Benzodiazepines






45. What is the mechanism of action of NSAIDs other than Aspirin?






46. What are signs of Sildenafil (Viagra) toxicity?






47. What is a Ribavirin toxicity?






48. Which diuretics decrease urine Ca2+?






49. What is the MOA of Aztreonam?






50. Which drug(s) cause this reaction: Pseudomembranous colitis?