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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is Ketoconazole specifically used for?






2. Which drug(s) cause this reaction: Oto and Nephrotoxicity (3)?






3. What is the clincial use for Misoprostol?






4. Describe first - order kinetics?






5. Antimicrobial prophylaxis for PCP






6. K+- clinical use?






7. What is the MOA of Ganciclovir?






8. Quinidine - toxicity?






9. What are common toxic side effects of Sulfonamides? (5)






10. How is Ribavirin used clinically?






11. What is a Ribavirin toxicity?






12. Ca2+ channel blockers - toxicity?






13. What are the products and their toxicities of the metabolism of ethanol by / alcohol dehydrogenase?






14. In What population does Gray Baby Syndrome occur? Why?






15. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






16. For Warfarin What is the Structure






17. Why are the Sulfonylureas inactive in IDDM (type -1)?






18. For Heparin What is the Onset of action






19. MOA: Disrupt bacterial/fungal cell membranes






20. What drug is used to diagnose myasthenia gravis?






21. Is resistant to penicillinase?






22. What is the possible mechanism and effect of Metformin in treating diabetes?






23. What is the MOA for Clindamycin?






24. How would you treat African Trypanosomiasis (sleeping sickness)?






25. What is the clinical use for Nystatin?






26. What is the effect of norepinephrine on bp and pulse pressure?






27. What is a common side effect of Misoprostol?






28. What is Niclosamide used for?






29. Does Warfarin have a long - medium - or short half life?






30. Name several common Macrolides (3)






31. Which Tetracycline is used in patients with renal failure? / Why?






32. Name two classes of drugs for HIV therapy






33. What are two toxicities associated with Cyclosporine?






34. What is the memory key for the effect of magnesium hydroxide overuse?






35. What antimicrobial class is Aztreonam syngergestic with?






36. What is the mechanism of action of the Alpha - glucosidase inhibitors?






37. What parasitic condition is treated with Ivermectin?


38. Which of the following would atropine administration cause? Hypothermia - bradycardia - excess salivation - dry flushed skin - or diarrhea






39. If a patient is given hexamethonium - What would happen to his/her heart rate?






40. What is the major side effect for Carbenicillin - Piperacillin - and Ticarcillin?






41. What is Metronidazole combined with for 'triple therapy'? Against What organism?






42. What can result due to antacid overuse?






43. What additional side effects exist for Ampicillin?






44. What type of gout is treated with Allopurinol?






45. What is the clinical use of Mifepristone (RU486)?






46. Furosemide - clinical use?






47. What are the four conditions in Which Omeprazole - Lansoprazole is used?






48. Foscarnet toxicity?






49. What is the mechanism of action of Misoprostol?






50. What are the major toxic side effects of the Cephalosporins?