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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the major toxic side effects of Imipenem/cilastatin?






2. Why is Cilastatin administered with Imipenem?






3. What are three types of antacids and the problems that can result from their overuse?






4. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






5. Adverse effects of Captopril?






6. Adverse effects of Minoxidil?






7. Name the common Nucleoside Reverse Transcriptase Inhibitors






8. What are three complications of Warfarin usage?






9. How does botulinum toxin result in respiratory arrest?






10. Secretion of What drug is inhibited by Probenacid used to treat chronic gout?






11. What sympathomimetic would you not prescribe for hypotension in a pt with renal artery sclerosis.






12. List the mechanism - clinical use - & toxicity of Methotrexate.






13. What is the mechanism of action of Probenacid used to treat chronic gout?






14. How does dantrolene work?






15. Which cancer drugs work at the level of mRNA(2)?






16. Resistance mechanisms for Cephalosporins/Penicillins






17. What is the most common cause of Pt noncompliance with Macrolides?






18. List the specific antidote for this toxin: TPA & Streptokinase






19. Resistance mechanisms for Tetracycline






20. Digoxin v. Digitoxin: protein binding?






21. What is Clindamycin used for clinically?






22. What physiological effects was the Anes using Atropine to tx






23. What microorganisms are Aminoglycosides ineffective against?






24. Which drug(s) cause this reaction: Torsade de pointes (2)?






25. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






26. List the specific antidote for this toxin: Copper






27. Antimicrobial prophylaxis for Meningococcal infection






28. What is the category and mechanism of action of Zileuton in Asthma treatment?






29. List five common glucocorticoids.






30. Antiarrhythmic class IA effects?






31. Acetazolamide - site of action?






32. Mannitol - site of action?






33. Describe Phase II metabolism in liver(3)?






34. What are the phases of succinylcholine neuromuscular blockade?






35. Why would dopamine be useful in treating shock?






36. What is the mechanism of action of the H2 Blockers?






37. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






38. Name five Antiarrhythmic drugs in class II?






39. What is the clinical use for Clomiphene?






40. How does NE modulate its own release? What other neurotransmitter has this same effect?






41. What cholinergic inhibitor acts by directly inhibiting Ach release at the presynaptic terminal






42. Specifically - How does Foscarnet inhibit viral DNA pol?






43. What is the MOA for Clindamycin?






44. How does a competitive antagonist effect an agonist?






45. What do Aminoglycosides require for uptake?






46. How is Griseofulvin used clinically?






47. What is the receptor affinity and clinical use of isoproterenol?






48. Which drug increases Sys BP w/o affecting Pulse Pressure






49. What is the category of drug names ending in - azol (e.g. Ketoconazole)






50. Describe the MOA of Interferons (INF)