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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the phases of succinylcholine neuromuscular blockade?






2. Which drug(s) cause this reaction: Anaphylaxis?






3. What is a Ribavirin toxicity?






4. List the mechanism - clinical use - & toxicity of Vincristine.

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5. What is treated with Chloroquine - Quinine - Mefloquine?






6. What is the category of drug names ending in - azepam (e.g. Diazepam)






7. What is the category of drug names ending in - terol (e.g. Albuterol)






8. Foscarnet does not require activation by a...






9. What is the MOA for the Cephalosporins?






10. What are two toxicities of the Sulfonylureas?






11. Adenosine - clinical use?






12. Why is pyridostigmine effective in the treatment of myasthenia gravis?






13. For Warfarin What is the Mechanism of action






14. Adverse effects of ganglionic blockers?






15. What is the memory key for Isoniazid (INH) toxicity?






16. Why would dopamine be useful in treating shock?






17. Resistance mechanisms for Macrolides

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18. What is the mechanism of action of Acetaminophen?






19. What are three possible complications of Heparin therapy?






20. Preferential action of the Ca2+ channel blockers at vascular smooth muscle?






21. What should not be taken with Tetracyclines? / Why?






22. What type of gout is treated with Allopurinol?






23. For Heparin What is the Structure






24. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






25. What are the classic symptoms of cholinesterase inhibitor poisoning (parathion or other organophosphates)?






26. Antiarrhythmic class II- toxicity?






27. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






28. What is used to reverse the action of Heparin?






29. What is the category of drug names ending in - ipramine (e.g. Imipramine)






30. Common toxicities associated with Fluoroquinolones?






31. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






32. What reversal agent could a Anes give to reverse the effects of Atropine






33. How can Vancomycin - induced 'Red Man Syndrome' be prevented?






34. For Heparin What is the Duration of action






35. Which drug(s) cause this reaction: SLE- like syndrome?






36. Adverse effects of Reserpine?






37. MOA: Block protein synthesis at 30s subunit






38. What is the MOA of Aztreonam?






39. Are Ampicillin and Amoxicillin are not...






40. How is Chloramphenical used clinically?






41. Which Aminoglycoside is used for Bowel Surgery ?






42. MOA: Block peptidoglycan synthesis






43. Beta Blockers - BP?






44. Name two organisms Vancomycin is commonly used for?






45. List the specific antidote for this toxin: Tricyclic antidepressants






46. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






47. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






48. What is the mechanism of action of Heparin?






49. Bretyllium - toxicity?






50. Antiarrhythmic class IC- toxicity?