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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are are the Sulfonylureas (general description) and What is their use?






2. Reserpine will block the syntheis of this drug and but not its precursor.






3. For Heparin What is the Site of action






4. Cautions When using Amiodarone?






5. What are the four conditions in Which Omeprazole - Lansoprazole is used?






6. Resistance mechanisms for Cephalosporins/Penicillins






7. Which diuretics increase urine Ca2+?






8. MOA: Block mRNA synthesis






9. Name common Polymyxins






10. Which cancer drugs effect nuclear DNA (4)?






11. What are four advantages of newer low - molecular - weight heparins (Enoxaparin)?






12. How are Interferons (INF) used clinically?

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13. What can result due to antacid overuse?






14. List the mechanism - clinical use - & toxicity of 6 MP.






15. What is the major toxic side effect of Penicillin?






16. What is a mnemonic to remember Amantadine's function?






17. Ryanodine - site of action?






18. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






19. Adverse effects of Nifedipine - verapamil?






20. Name three calcium channel blockers?






21. What is the memory key involving the '4 R's of Rifampin?'






22. MOA: Block protein synthesis at 50s subunit






23. What is an additional side effect of Methicillin?






24. How is Amphotericin B administered for fungal meningitis?






25. What is the mechanism of action of Acetaminophen?






26. What is the MOA of Imipenem?






27. For Heparin What is the Mechanism of action






28. Clinical use of Isoniazid (INH)?






29. Which drug(s) cause this reaction: Osteoporosis (2)?






30. How would you treat African Trypanosomiasis (sleeping sickness)?






31. What is the mechanism of action of Ticlopidine - Clopidogrel






32. What is Metronidazole combined with for 'triple therapy'? Against What organism?






33. How would hemicholinium treatment affect cholinergic neurons?






34. Adverse effects of Clonidine?






35. What are the clinical uses for Aztreonam?






36. Why would you use pralidoxime after exposure to an organophosphate?






37. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






38. Common toxicities associated with Fluoroquinolones?






39. How can Vancomycin - induced 'Red Man Syndrome' be prevented?






40. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






41. What are four conditions in Which H2 Blockers are used clinically?






42. For Heparin What is the Lab value to monitor






43. Ibutilide - toxicity?






44. Antiarrhythmic Class III- effects?






45. What is the mechanism of action of the Alpha - glucosidase inhibitors?






46. A 57 yo heart failure pt develops cardiac decompensation - What drug will give you adequate perfusion of his kidneys as well as tx for his Hypotension






47. What are four clinical uses of glucocorticoids?

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48. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






49. Thiazides - site of action?






50. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?