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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which drug(s) cause this reaction: Anaphylaxis?






2. Which drug(s) cause this reaction: Gynecomastia (6)?






3. What are two toxicities associated with Cyclosporine?






4. What are Aminoglycosides synergistic with?






5. What is the mechanism of action of Cyclosporine?






6. Which drug(s) cause this reaction: Diabetes insipidus?






7. List the specific antidote for this toxin: Amphetamine






8. What type of patient should not take Misoprostol and why?






9. List the mechanism - clinical use - & toxicity of Cisplatin.






10. What is the formula for Volume of distribution (Vd)






11. What is the category of drug names ending in - navir (e.g. Saquinavir)






12. What is a prerequisite for Acyclovir activation?






13. What is the memory key for the effect of magnesium hydroxide overuse?






14. What is the MOA of the RT Inhibitors?






15. How is Amphotericin B administered for fungal meningitis?






16. What is the memory aid for subunit distribution of ribosomal inhibitors?

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17. Name three calcium channel blockers?






18. What is Metronidazole combined with for 'triple therapy'? Against What organism?






19. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






20. For Warfarin What is the Onset of action






21. What is the mechanism of action of the Sulfonylureas?






22. Why is reserpine effective in treating HTN?






23. Which drug(s) cause this reaction: Agranulocytosis (3)?






24. What are the clinical indications for bethanechol?






25. What are Aminoglycosides used for clinically?






26. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?






27. Preferential action of the Ca2+ channel blockers at cardiac muscle?






28. What is a possible toxicity of Alpha - glucosidase inhibitors used in type -2 diabetes?






29. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






30. What drug is given for Pneumocystis carinii prophylaxis?






31. Adverse effects of Nifedipine - verapamil?






32. What are five toxicities associated with Tacrolimus (FK506)?






33. Adverse effects of Captopril?






34. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






35. Which drug(s) cause this reaction: G6PD hemolysis(8)?






36. For Warfarin What is the Structure






37. What is the mechanism of action of Sildenafil (Viagra)?






38. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






39. Secretion of What drug is inhibited by Probenacid used to treat chronic gout?






40. What are four thrombolytics?






41. What is the MOA for Trimethoprim (TMP)?






42. What are three complications of Warfarin usage?






43. What are the clinical uses for Imipenem/cilastatin?






44. MOA: Block protein synthesis at 30s subunit






45. What are the clinical uses for 1st Generation Cephalosporins?






46. A common side effects of Interferon (INF) treatment is?






47. List the specific antidote for this toxin: Antimuscarinic (anticholinergic)






48. Describe Phase II metabolism in liver(3)?






49. What microorganisms is Aztreonam not effective against?






50. What antimuscarinic agent is used in asthma and COPD?