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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the classic symptoms of cholinesterase inhibitor poisoning (parathion or other organophosphates)?






2. Ibutilide - toxicity?






3. Why does atropine dilate the pupil?






4. Antiarrhythmic class IV- primary site of action?






5. What is the clinical use for Heparin?






6. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






7. How do spare receptors effect the Km?






8. Name two bile acid resins.






9. What is the category of drug names ending in - cillin (e.g. Methicillin)






10. Name the common Nucleoside Reverse Transcriptase Inhibitors






11. What is combination TMP- SMZ used to treat?






12. What is the MOA for the Fluoroquinolones?






13. How can the toxic effects of TMP be ameliorated?






14. What is the MOA of Isoniazid (INH)?






15. List the specific antidote for this toxin: Lead






16. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






17. Why does NE result in bradycardia?






18. Which of epi - norepi - or isoproterenol results in bradycardia?






19. What is the MOA for the Tetracyclines?






20. Sotalol - toxicity?






21. Mannitol - site of action?






22. What is the category of drug names ending in - azine (e.g. Chlorpromazine)






23. What is treated with Chloroquine - Quinine - Mefloquine?






24. Steady state concentration is reached in __ number of half - lifes






25. Resistance mechanisms for Aminoglycosides






26. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






27. Which diuretics decrease urine Ca2+?






28. What is a sign of toxicity with the use of thrombolytics?






29. What is the specific clinical use of Indomethacin in neonates?






30. What is a possible toxicity of Alpha - glucosidase inhibitors used in type -2 diabetes?






31. What is the MOA for Rifampin?






32. What sympathomimetic would you not prescribe for hypotension in a pt with renal artery sclerosis.






33. Antiarrhythmic class IV- effects?






34. What is the MOA of Ganciclovir?






35. Which RT inhibitors cause a Rash?






36. What is the effect of epinephrine infusion on bp and pulse pressure?






37. What is the category of drug names ending in - azepam (e.g. Diazepam)






38. What is the clinical utility of clonidine?






39. Which drug(s) cause this reaction: Hepatitis?






40. What are two types of drugs that interfere with the action of Sucralfate and why?






41. Furosemide - clinical use?






42. Adenosine - clinical use?






43. Beta Blockers - CV toxicity?






44. What is the MOA of Imipenem?






45. What is the category of drug names ending in - navir (e.g. Saquinavir)






46. Beta Blockers - site of action?






47. For Warfarin What is the Mechanism of action






48. What are three toxicities of Leuprolied?






49. MOA of Succinylcholine






50. Adverse effect of Nitroprusside?