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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Foscarnet does not require activation by a...






2. Which drug increases Sys BP w/o affecting Pulse Pressure






3. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






4. How do spare receptors effect the Km?






5. What is the chemical name for Ganciclovir?






6. What effect would atropine have on a patient with peptic ulcer disease?






7. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






8. What is the clinical use for Warfarin?






9. Which cancer drugs effect nuclear DNA (4)?






10. Name four HMG- CoA reductase inhibitors.






11. What is the mechanism of action of Probenacid used to treat chronic gout?






12. MOA: Block protein synthesis at 30s subunit






13. Name several common Macrolides (3)






14. List the specific antidote for this toxin: Arsenic (all heavy metals)






15. Which drug(s) cause this reaction: Oto and Nephrotoxicity (3)?






16. What is the category - mechanism of action - and effect of Ipratroprium in Asthma treatment?






17. What is the MOA for Rifampin?






18. What Sulfonamides are used for simple UTIs?






19. What are the Macrolides used for clinically?






20. Which RT inhibitor causes Megaloblastic Anemia?






21. For Warfarin What is the Duration of action






22. Name the common Fluoroquinolones (6)






23. What is a possible result of overdose of Acetaminophen?






24. Ibutilide - toxicity?






25. Why would you use pralidoxime after exposure to an organophosphate?






26. For Warfarin What is the Ability to inhibit coagulation in vitro






27. What are common side effects of Amphotericin B?






28. What is the clinical use for Ampicillin and Amoxicillin?






29. For Warfarin What is the Mechanism of action






30. Which drug(s) cause this reaction: Tendonitis and rupture?






31. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






32. What enzyme is responsible for the degredation of Ach






33. Which receptors does phenylephrine act upon?






34. For Warfarin What is the Structure






35. What is a possible toxicity of Alpha - glucosidase inhibitors used in type -2 diabetes?






36. Why is Cilastatin administered with Imipenem?






37. What is the specific clinical use of Indomethacin in neonates?






38. List five common glucocorticoids.






39. Which drug(s) cause this reaction: G6PD hemolysis(8)?






40. IV Penicillin






41. What organism is Imipenem/cilastatin the Drug of Choice for?






42. Aztreonam is not ________ with penicillins






43. Which drug(s) cause this reaction: Torsade de pointes (2)?






44. Ganciclovir associated toxicities?






45. Are penicillinase resistant






46. What is the definition of zero - order kinetics? Example?






47. For Warfarin What is the Onset of action






48. What is the major side effect for Ampicillin and Amoxicillin?






49. Which Tetracycline is used in patients with renal failure? / Why?






50. How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax - P.ovale) treated?







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