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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are four unwanted effects of Clomiphene use?






2. MOA for Penicillin (3 answers)?






3. What are signs of Sildenafil (Viagra) toxicity?






4. Why are albuterol and terbutaline effective in tx of acute asthmatic attacks?






5. Which cancer drugs effect nuclear DNA (4)?






6. What are the clinical uses for 1st Generation Cephalosporins?






7. What is the MOA of Amantadine?






8. Why does atropine dilate the pupil?






9. What parasites are treated with Pyrantel Pamoate (more specific)?






10. What are the clinical uses for 2nd Generation Cephalosporins?






11. What are the major structural differences between Penicillin and Cephalosporin?






12. What populations are Floroquinolones contraindicated in? Why?






13. ACE inhibitors - mechanism?






14. What is the clinical utility of clonidine?






15. Why does NE result in bradycardia?






16. What do you treat Nematode/roundworm (pinworm - whipworm) infections with?






17. What are two indirect acting adrenergic agonists?






18. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






19. What is the formula for Volume of distribution (Vd)






20. What are the side effects of Rifampin?






21. Explain differences between full and partial agonists(2).






22. What is Metronidazole combined with for 'triple therapy'? Against What organism?






23. What are three common NSAIDS other than Aspirin?






24. MOA: Block nucleotide synthesis






25. Side effects of Isoniazid (INH)?






26. List the mechanism - clinical use - & toxicity of 6 MP.






27. How is Vancomycin used clinically?






28. What are the clinical indications for bethanechol?






29. Mannitol - clinical use?






30. Which drug(s) cause this reaction: SLE- like syndrome?






31. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






32. What is the MOA for the Macrolides?






33. Name some common Sulfonamides (4)






34. Explain pH dependent urinary drug elimination?






35. What is a Ribavirin toxicity?






36. What is the category of drug names ending in - cycline (e.g. Tetracycline)






37. Are not penicillinase resistant






38. What are Fluoroquinolones indicated for? (3)






39. When is HIV therapy initiated?






40. Which drug increases Sys BP w/o affecting Pulse Pressure






41. What is the possible mechanism and effect of Metformin in treating diabetes?






42. As an Anes you want to use a depolarizing neuromuscular blocking drug on your pt - What do you use






43. Name three Antiarrhythmic drugs in class IV.






44. What are the clinical uses for 3rd Generation Cephalosporins?






45. Ethacrynic Acid - toxicity?






46. What are five disadvantages of Oral Contraceptives (synthetic progestins - estrogen)?






47. List the mechanism - clinical use - & toxicity of Nitrosureas.






48. What are five toxicities associated with Tacrolimus (FK506)?






49. Isopoterenol was given to a patient with a developing AV block - why?






50. ACE inhibitors - toxicity?