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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which cancer drugs work at the level of proteins(2)?






2. Resistance mechanisms for Macrolides

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3. Resistance mechanisms for Cephalosporins/Penicillins






4. What is the clinical use for Sildenafil (Viagra)?






5. What is the mechanism of action of NSAIDs other than Aspirin?






6. List the specific antidote for this toxin: Heparin






7. Mannitol - toxicity?






8. Furosemide - toxicity? (OH DANG)






9. Digoxin v. Digitoxin: protein binding?






10. Which drug(s) cause this reaction: Torsade de pointes (2)?






11. Which drug(s) cause this reaction: Fanconi's syndrome?






12. For Heparin What is the Structure






13. What is the category and mechanism of action of Zafirlukast in Asthma treatment?






14. Which drug(s) cause this reaction: Hepatitis?






15. What is the major toxic side effect of Penicillin?






16. What is the mechanism of action of Colchicine used to treat acute gout?






17. Which drug(s) cause this reaction: Gingival hyperplasia?






18. What are two clinical uses of Azathioprine?






19. Side effects of Isoniazid (INH)?






20. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






21. How is Amphotericin B administered for fungal meningitis?






22. Ethacrynic Acid - mechanism?






23. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






24. Ryanodine - site of action?






25. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






26. ________ ae not resistant to penicillinase - - but they are less susceptible than the other Beta lactams






27. In What population does Gray Baby Syndrome occur? Why?






28. What type of neurological blockade would hexamethonium create?






29. What are common toxic side effects of Sulfonamides? (5)






30. When is Rifampin not used in combination with other drugs?






31. What is the chemical name for Ganciclovir?






32. How is Ribavirin used clinically?






33. List the specific antidote for this toxin: Methemoglobin






34. Which drug(s) cause this reaction: Cinchonism (2)?






35. What is the clinical utility of clonidine?






36. For Warfarin What is the Treatment for overdose






37. Name three Antiarrhythmic drugs in class IV.






38. Mannitol - mechanism?






39. Antiarrhythmic class II- effects?






40. Which Aminoglycoside is used for Bowel Surgery ?






41. Resistance mechanisms for Tetracycline






42. What is an acronym to remember Anti - TB drugs?






43. Which drug(s) cause this reaction: Diabetes insipidus?






44. How does dantrolene work?






45. List the specific antidote for this toxin: Digitalis






46. What are common toxicities related to Vancomycin therapy?

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47. What is the MOA for Acyclovir?






48. What are two Alpha - glucosidase inhibitors?






49. How is Vancomycin used clinically?






50. For Warfarin What is the Onset of action