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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the category of drug names ending in - pril (e.g. Captopril)






2. What is the major toxic side effect of Penicillin?






3. Ibutilide - toxicity?






4. What are three clinical uses of the NSAIDs?






5. How does resistance to Vancomycin occur?






6. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






7. Antiarrhythmic class IV- primary site of action?






8. Antiarrhythmic class IB- effects?






9. How do we stop angina?






10. What are two indirect acting adrenergic agonists?






11. How is Ganciclovir used clinically?






12. Sotalol - toxicity?






13. Which drug(s) cause this reaction: Fanconi's syndrome?






14. What are common toxicities associated with Tetracyclines?

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15. Antiarrhythmic class II- toxicity?






16. What process does Zafirlukast interfere with?






17. List the mechanism - clinical use - & toxicity of Doxorubicin.

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18. What is the category and mechanism of action of Zileuton in Asthma treatment?






19. What is the MOA for Rifampin?






20. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?






21. Furosemide increases the excretion of What ion?






22. MOA: Disrupt bacterial/fungal cell membranes






23. Which diuretics increase urine Ca2+?






24. What is the mechanism of Tacrolimus (FK506)?






25. What is the clinical use for Sildenafil (Viagra)?






26. List the specific antidote for this toxin: Copper






27. Why is Cilastatin administered with Imipenem?






28. Describe first - order kinetics?






29. What neurotransmitter does Amantadine affect? How does it influence this NT?






30. As an Anes you want to use a depolarizing neuromuscular blocking drug on your pt - What do you use






31. Adverse effects of Methyldopa?

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32. Which Aminoglycoside is used for Bowel Surgery ?






33. What antimuscarinic agent is used in asthma and COPD?






34. What drug is used to treat Trematode/fluke (e.g. - Schistosomes - Paragonimus - Clonorchis) or Cysticercosis






35. What are Amantadine - associated side effects?






36. Which of epi - norepi - or isoproterenol results in bradycardia?






37. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






38. What is the possible mechanism and effect of Metformin in treating diabetes?






39. List the mechanism - clinical use - & toxicity of Tamoxifen.






40. What is the MOA of Isoniazid (INH)?






41. What are four Sulfonylureas?






42. Does Ampicillin or Amoxicillin have a greater oral bioavailability?






43. Which drug(s) cause this reaction: Diabetes insipidus?






44. What is the MOA for Nystatin?






45. Foscarnet toxicity?






46. ADH antagonists - site of action?






47. K+- clinical use?






48. What is the MOA for Acyclovir?






49. Which drug(s) cause this reaction: Hepatitis?






50. What is the mechanism of Leuprolide?