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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Ca2+ channel blockers - site of action?






2. MOA: Disrupt bacterial/fungal cell membranes






3. Name two bile acid resins.






4. What is the only depolarizing neuromuscular blocking agent?






5. What is the receptor affinity and clinical use of isoproterenol?






6. What are two processes Corticosteroids inhibit leading to decreased inflammation?






7. Amiodarone - toxicity?






8. What are the side effects of Rifampin?






9. What physiological effects was the Anes using Atropine to tx






10. Adverse effects of Nifedipine - verapamil?






11. Beta Blockers - BP?






12. MOA: Disrupt fungal cell membranes






13. What is the mechanism of Tacrolimus (FK506)?






14. What is the MOA for Clindamycin?






15. Antimicrobial prophylaxis for Gonorrhea






16. What are nine findings of Iatrogenic Cushing's syndrome caused by glucocorticoid therapy?






17. What is the MOA of Isoniazid (INH)?






18. For Warfarin What is the Ability to inhibit coagulation in vitro






19. What is the category - desired effect - and adverse effect of Isoproterenol in the treatment of Asthma?






20. What drug is used to diagnose myasthenia gravis?






21. What are three clinical uses of the Leuprolide?






22. What are three types of antacids and the problems that can result from their overuse?






23. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






24. MOA: Bactericidal antibiotics






25. What neurotransmitter does Amantadine affect? How does it influence this NT?






26. Why are the Sulfonylureas inactive in IDDM (type -1)?






27. Why is there a drop in systolic - mean - and diastolic bp with infusion of isoproterenol?






28. What are are the Sulfonylureas (general description) and What is their use?






29. Where does Griseofulvin deposit?






30. What are the clinical uses for 1st Generation Cephalosporins?






31. Name two classes of drugs for HIV therapy






32. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






33. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






34. What are three possible toxicities of NSAID usage?






35. Toxic side effects of the Azoles?






36. What are five toxicities associated with Tacrolimus (FK506)?






37. How do we stop angina?






38. Which drug(s) cause this reaction: P450 inhibition(6)?






39. What is the effect of guanethidine on adrenergic NE release?






40. What are the clinical uses for Aztreonam?






41. ___________ are Teratogenic






42. Describe the MOA of Interferons (INF)






43. What is the mechanism of action of the Alpha - glucosidase inhibitors?






44. Adverse effects of beta - blockers?






45. Resistance mechanisms for Aminoglycosides






46. Beta Blockers - CV toxicity?






47. What is the memory key for the effect of aluminum hydroxide overuse?






48. What are common toxicities associated with Macrolides? (4)






49. What is the MOA for Metronidazole?






50. What microorganisms are Aminoglycosides ineffective against?