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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. MOA: Block peptidoglycan synthesis






2. How is Amantadine used clinically?

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3. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






4. How can the toxic effects of TMP be ameliorated?






5. What are two indirect acting adrenergic agonists?






6. List the specific antidote for this toxin: Methemoglobin






7. Spironolactone - mechanism?






8. What is the difference in receptor affinity of epinephrine at low doses? High doses?

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9. K+ sparing diuretics - site of action?






10. K+- clinical use?






11. What is the mechanism of action of NSAIDs other than Aspirin?






12. Digitalis - site of action?






13. MOA: Bactericidal antibiotics






14. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






15. What is the MOA for Nystatin?






16. What are common toxic side effects of Sulfonamides? (5)






17. Which drug(s) cause this reaction: Gray baby syndrome?






18. What is the effect of norepinephrine on bp and pulse pressure?






19. Is resistant to penicillinase?






20. What are common serious side effects of Aminoglycosides and What are these associated with?






21. Adenosine - clinical use?






22. MOA: Block nucleotide synthesis






23. What are the major toxic side effects of Imipenem/cilastatin?






24. List the specific antidote for this toxin: Cyanide






25. Digoxin v. Digitoxin: protein binding?






26. What is treated with Chloroquine - Quinine - Mefloquine?






27. What are three toxicities of Leuprolied?






28. What is the mechanism of action and clinical use of the antiandrogens Ketoconazole and Spironolactone?






29. What antimuscarinic agent is used in asthma and COPD?






30. What are three common NSAIDS other than Aspirin?






31. How does Ganciclovir's toxicity relate to that of Acyclovir?






32. Which of these three drugs will cause a reflex bradycardia in your pt (Norepi - Epi - or Isoporterenol)






33. Which drug(s) cause this reaction: Neuro and Nephrotoxic?






34. What are five possible toxic effects of Aspirin therapy?

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35. Name some common Sulfonamides (4)






36. Decrease Digitoxin dose in renal failure?






37. How would you reverse the effect of a neuromuscular blocking agent?






38. What is the mechanism of action of Misoprostol?






39. Name several common Macrolides (3)






40. Adverse effects of Reserpine?






41. What is the mechanism of action of Clomiphene?






42. What is the MOA of Foscarnet?






43. What are four clinical activities of Aspirin?






44. Adverse effects of Loop Diuretics?






45. What are four clinical uses of glucocorticoids?

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46. What would be the effect on blood pressure with infusion of the alpha -2 agonist clonidine?






47. List the specific antidote for this toxin: Amphetamine






48. Antiarrhythmic class IB- clinical uses?






49. Loop diuretics (furosemide)- site of action?






50. What is clinical use for Carbenicillin - Piperacillin - and Ticarcillin?







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