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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which RT inhibitors cause Lactic Acidosis?






2. What is the mechanism of action of the glucocorticoids?






3. What are common side effects of RT Inhibitors?






4. How is Leishmaniasis treated?






5. What antimicrobial class is Aztreonam syngergestic with?






6. What musculo - skeletal side effects in Adults are associated with Floroquinolones?






7. Bretyllium - toxicity?






8. What is the mechanism of Leuprolide?






9. How is Foscarnet used clinically?






10. What can result due to antacid overuse?






11. MOA for Penicillin (3 answers)?






12. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?






13. Which drug(s) cause this reaction: P450 inhibition(6)?






14. List the mechanism - clinical use - & toxicity of Methotrexate.






15. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






16. Which of these three drugs will cause a reflex bradycardia in your pt (Norepi - Epi - or Isoporterenol)






17. What are major side effects of Methicillin - Nafcillin - and Dicloxacillin?






18. What is a possible result of overdose of Acetaminophen?






19. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






20. For Heparin What is the Onset of action






21. What is the MOA of Ganciclovir?






22. What is Imipenem always administered with?






23. Adverse effects of Hydralazine?






24. IV Penicillin






25. How would hemicholinium treatment affect cholinergic neurons?






26. What is the lab value used to monitor the effectiveness of Heparin therapy?






27. Name two bile acid resins.






28. Do Tetracyclines penetrate the CNS?






29. What is the MOA of Polymyxins?






30. MOA: Disrupt bacterial/fungal cell membranes






31. What are the nondepolarizing neuromuscular blocking drugs?






32. Decrease Digoxin dose in renal failure?






33. How would you reverse the effect of a neuromuscular blocking agent?






34. What is the mechanism of action of Omeprazole - Lansoprazole?






35. What is the memory key for organisms treated with Tetracyclines?

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36. How does botulinum toxin result in respiratory arrest?






37. What is the MOA for the Azoles?






38. Procainamide - toxicity?






39. Name the common Fluoroquinolones (6)






40. What is the mechanism of action of Clomiphene?






41. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






42. Why would you use pralidoxime after exposure to an organophosphate?






43. Which individuals are predisposed to Sulfonamide - induced hemolysis?






44. What are two types of drugs that interfere with the action of Sucralfate and why?






45. Hydralazine - toxicity?






46. Adverse effects of ganglionic blockers?






47. What are the clinical uses for 2nd Generation Cephalosporins?






48. Digoxin v. Digitoxin: half life?






49. What is a sign of toxicity with the use of thrombolytics?






50. In coma situations you rule out What (7)?

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