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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Ethacrynic Acid - mechanism?






2. What is are two clinical uses of Cyclosporine?






3. What is the mechanism of action of Sildenafil (Viagra)?






4. What is the clinical use for Sildenafil (Viagra)?






5. List the mechanism - clinical use - & toxicity of Paclitaxel.






6. Which drug(s) cause this reaction: Cutaneous flushing (4)?






7. What are the clinical uses for 2nd Generation Cephalosporins?






8. How does Ganciclovir's toxicity relate to that of Acyclovir?






9. What is an additional side effect of Methicillin?






10. What microorganisms are clinical indications for Tetracycline therapy?


11. Name the steps in drug approval(4)?






12. Acetaminophen has What two clinical uses and lacks What one clinical use of the NSAIDs?






13. How is Amphotericin B administered for fungal meningitis?






14. For Heparin What is the Duration of action






15. Are not penicillinase resistant






16. What is the category of drug names ending in - pril (e.g. Captopril)






17. Which of these three drugs will cause a reflex bradycardia in your pt (Norepi - Epi - or Isoporterenol)






18. How is Ribavirin used clinically?






19. What are two toxicities of the Glitazones?






20. For Warfarin What is the Ability to inhibit coagulation in vitro






21. What physiological effects was the Anes using Atropine to tx






22. What is the MOA for the Aminoglycosides?






23. How would you treat African Trypanosomiasis (sleeping sickness)?






24. Why are albuterol and terbutaline effective in tx of acute asthmatic attacks?






25. Common side effects associated with Clindamycin include?






26. For Warfarin What is the Treatment for overdose






27. What drugs target anticholinesterase






28. What is the major side effect for Ampicillin and Amoxicillin?






29. What is the MOA for Trimethoprim (TMP)?






30. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






31. What is the category of drug names ending in - cycline (e.g. Tetracycline)






32. List the mechanism - clinical use - & toxicity of Cisplatin.






33. What is the clinical use of Mifepristone (RU486)?






34. What is a prerequisite for Acyclovir activation?






35. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






36. Resistance mechanisms for Aminoglycosides






37. Which drug(s) cause this reaction: Tendonitis and rupture?






38. What class of drug is echothiophate? What is its indication?






39. What is the mechanism of action of Misoprostol?






40. Toxic side effects of the Azoles?






41. Adverse effect of Nitroprusside?






42. Furosemide - class and mechanism?






43. Cocaine shares is mechanism of action with What antidepressant






44. For Heparin What is the Lab value to monitor






45. How does a noncompetitive antagonist effect an agonist?






46. What is the effect of epinephrine infusion on bp and pulse pressure?






47. Acetazolamide causes?


48. Digoxin v. Digitoxin: excretion?






49. What drug is used to diagnose myasthenia gravis?






50. Which diuretics cause acidosis?