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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antiarrhythmic class II- effects?






2. What are three unwanted effects of Mifepristone?






3. What is the possible mechanism and effect of Metformin in treating diabetes?






4. What is the main clinical use for the thrombolytics?






5. Which drug(s) cause this reaction: G6PD hemolysis(8)?






6. What is the category of drug names ending in - navir (e.g. Saquinavir)






7. What is used to reverse the action of Heparin?






8. How does NE modulate its own release? What other neurotransmitter has this same effect?






9. Hydralazine - class and mechanism?






10. What is the MOA for Metronidazole?






11. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






12. How does Ganciclovir's toxicity relate to that of Acyclovir?






13. Furosemide increases the excretion of What ion?






14. List the specific antidote for this toxin: Carbon monoxide






15. How would you reverse the effect of a neuromuscular blocking agent?






16. Which drug(s) cause this reaction: Focal to massive hepatic necrosis (4)?






17. List the mechanism - clinical use - & toxicity of Tamoxifen.






18. Does Heparin have a long - medium - or short half life?






19. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






20. List the mechanism - clinical use - & toxicity of Methotrexate.






21. What is the category of drug names ending in - zosin (e.g. Prazosin)






22. Describe Phase II metabolism in liver(3)?






23. What is the memory key for organisms treated with Tetracyclines?

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24. Digoxin v. Digitoxin: half life?






25. What is the category - mechanism of action - and effect of Ipratroprium in Asthma treatment?






26. What is treated with Chloroquine - Quinine - Mefloquine?






27. What is the mechanism of action of Omeprazole - Lansoprazole?






28. What is a common drug interaction associated with Griseofulvin?






29. What drug is given for Pneumocystis carinii prophylaxis?






30. What are Polymyxins used for?






31. Preferential action of the Ca2+ channel blockers at cardiac muscle?






32. What do you treat Nematode/roundworm (pinworm - whipworm) infections with?






33. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






34. Are not penicillinase resistant






35. Hydralazine - toxicity?






36. What are four advantages of newer low - molecular - weight heparins (Enoxaparin)?






37. List the mechanism - clinical use - & toxicity of Etoposide.






38. What are two conditions in Which COX-2 inhibitors might be used?






39. List the mechanism - clinical use - & toxicity of 5 FU.






40. What is the category of drug names ending in - cillin (e.g. Methicillin)






41. What organisms does Griseofulvin target?






42. Which drug(s) cause this reaction: Gynecomastia (6)?






43. What are two clinical uses of Azathioprine?






44. Name some common Sulfonamides (4)






45. MOA: Disrupt bacterial/fungal cell membranes






46. What is the mechanism of action of Clomiphene?






47. What is the category of drug names ending in - triptyline (e.g. Amitriptyline)






48. What is the MOA of Griseofulvin?






49. List the specific antidote for this toxin: Iron






50. Adverse effects of Captopril?