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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is action of insulin in the liver - in muscle - and in adipose tissue?






2. What is Imipenem always administered with?






3. Where does Griseofulvin deposit?






4. What drugs target anticholinesterase






5. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






6. What type of gout is treated with Allopurinol?






7. What is treated with Chloroquine - Quinine - Mefloquine?






8. What is the mecanism of action of Sucralfate?






9. List the mechanism - clinical use - & toxicity of Doxorubicin.

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10. How do the Protease Inhibitors work?






11. Antiarrhythmic class IC- effects?






12. What is an additional side effect of Methicillin?






13. For Warfarin What is the Onset of action






14. What is the mechanism of action of Cyclosporine?






15. What is the difference between the affinity for beta receptors between albuterol/terbutaline and dantroline?






16. Name the common Aminoglycosides (5)






17. Does Ampicillin or Amoxicillin have a greater oral bioavailability?






18. What is the mechanism of action of Sildenafil (Viagra)?






19. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






20. What is the mechanism of action of the Sulfonylureas?






21. What can result due to antacid overuse?






22. Resistance mechanisms for Sulfonamides






23. How are Interferons (INF) used clinically?

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24. What is the mechanism of Tacrolimus (FK506)?






25. How do we stop angina?






26. What are two indirect acting adrenergic agonists?






27. What is the clinical use for Warfarin?






28. What are common side effects of RT Inhibitors?






29. List the specific antidote for this toxin: Cyanide






30. How is Leishmaniasis treated?






31. Antiarrhythmic class IA effects?






32. Ca2+ channel blockers - toxicity?






33. What is the MOA for the Tetracyclines?






34. What is the MOA of Polymyxins?






35. Name several common Macrolides (3)






36. Antimicrobial prophylaxis for Syphilis






37. List the specific antidote for this toxin: Iron






38. What is the mechanism of action of Probenacid used to treat chronic gout?






39. How is Amantadine used clinically?

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40. How do you treat coma in the ER (4)?






41. What side effect of using atropine to induce pupillary dilation would you expect?






42. Name two LPL stimulators.






43. Name five Antiarrhythmic drugs in class II?






44. Name some common Tetracyclines (4)






45. What are the Macrolides used for clinically?






46. Cocaine casues vasoconstriction and local anesthesia by What mechanism






47. What is the category - method of use - and adverse effects of Salmeterol in Asthma treatment?






48. Acetaminophen has What two clinical uses and lacks What one clinical use of the NSAIDs?






49. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






50. How does botulinum toxin result in respiratory arrest?







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