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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are three toxicities of Propylthiouracil?






2. What is the category - mechanism of action - and particular use of beclomethasone and prednisone in Asthma treatment?






3. What is Metronidazole combined with for 'triple therapy'? Against What organism?






4. Describe Phase I metabolism in liver(3)?






5. Are not penicillinase resistant






6. MOA for Penicillin (3 answers)?






7. Name the common Aminoglycosides (5)






8. List the specific antidote for this toxin: Warfarin






9. Which of the following would atropine administration cause? Hypothermia - bradycardia - excess salivation - dry flushed skin - or diarrhea






10. For Heparin What is the Treatment for overdose






11. What are the clinical uses for 3rd Generation Cephalosporins?






12. Are Ampicillin and Amoxicillin are not...






13. What are the clinical uses for 1st Generation Cephalosporins?






14. Beta Blockers - BP?






15. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






16. Which drug(s) cause this reaction: Stevens - Johnson syn. (3)?






17. Name four Antiarrhythmic drugs in class III.






18. Which drug(s) cause this reaction: Diabetes insipidus?






19. What are three toxicities of Leuprolied?






20. What would be the effect on blood pressure with infusion of the alpha -2 agonist clonidine?






21. Which drug(s) cause this reaction: Gynecomastia (6)?






22. How is Acyclovir used clinically?






23. What drug is given for Pneumocystis carinii prophylaxis?






24. Amprotericin B ___________ the BBB






25. Acetazolamide - mechanism?






26. Ryanodine - site of action?






27. What is the loading dose formula?






28. What microorganisms are clinical indications for Tetracycline therapy?

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29. What organisms does Griseofulvin target?






30. Aztreonam is not ________ with penicillins






31. What are are the Sulfonylureas (general description) and What is their use?






32. List the mechanism - clinical use - & toxicity of Etoposide.






33. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






34. Resistance mechanisms for Tetracycline






35. Which diuretics decrease urine Ca2+?






36. What populations are Floroquinolones contraindicated in? Why?






37. Antimicrobial prophylaxis for Gonorrhea






38. Which diuretics cause acidosis?






39. Why does atropine dilate the pupil?






40. Hydrochlorothiazide - mechanism?






41. Name several common Macrolides (3)






42. What enzyme does Zileuton inhibit?






43. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






44. Mg+- clinical use?






45. Which antimuscarinic agents are used in producing mydriasis and cycloplegia?






46. Esmolol - short or long acting?






47. Which drug(s) cause this reaction: Tendonitis and rupture?






48. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






49. Which antimicrobial classes inhibit protein synthesis at the 30S subunit? (2)






50. Ethacrynic Acid - toxicity?