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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Furosemide - clinical use?






2. Name three calcium channel blockers?






3. What is the mechanism of action of the Sulfonylureas?






4. Which diuretics increase urine NaCl?






5. Hydrochlorothiazide - clinical use?






6. MOA: Block mRNA synthesis






7. What are four unwanted effects of Clomiphene use?






8. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






9. Can Warfarin be used during pregnancy?






10. Describe Phase I metabolism in liver(3)?






11. What is the category of drug names ending in - azine (e.g. Chlorpromazine)






12. Which cancer drugs work at the level of mRNA(2)?






13. Name three K+ sparing diuretics?






14. How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax - P.ovale) treated?






15. What is the MOA for Ampicillin and Amoxicillin?






16. What are two Alpha - glucosidase inhibitors?






17. What parasites are treated with Pyrantel Pamoate (more specific)?






18. What is the mechanism of action of Colchicine used to treat acute gout?






19. Name two bile acid resins.






20. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






21. Name five Antiarrhythmic drugs in class II?






22. Name two classes of drugs for HIV therapy






23. What is the category of drug names ending in - pril (e.g. Captopril)






24. What are two clinical uses of Azathioprine?






25. List the specific antidote for this toxin: TPA & Streptokinase






26. What is the MOA for the Azoles?






27. For Heparin What is the Onset of action






28. Furosemide - toxicity? (OH DANG)






29. What type of gout is treated with Probenacid?






30. What is the MOA of Amantadine?






31. Antiarrhythmic class IV- clinical use?






32. Which diuretics increase urine K+?






33. How do we stop angina?






34. What musculo - skeletal side effects in Adults are associated with Floroquinolones?






35. For Heparin What is the Site of action






36. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






37. A common side effects of Interferon (INF) treatment is?






38. How is Vancomycin used clinically?






39. What is the category - mechanism of action - and particular use of beclomethasone and prednisone in Asthma treatment?






40. What are two types of drugs that interfere with the action of Sucralfate and why?






41. What is the mechanism of action of Cyclosporine?






42. What is the mechanism of Tacrolimus (FK506)?






43. What antimuscarinic drug is useful for the tx of asthma






44. Which diuretics cause alkalosis?






45. What are four clinical uses of glucocorticoids?

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46. In coma situations you rule out What (7)?

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47. What is the clincial use for Misoprostol?






48. Adverse effects of Guanethidine?






49. Why is there a drop in systolic - mean - and diastolic bp with infusion of isoproterenol?






50. Adverse effects of Minoxidil?