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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the major toxic side effects of Imipenem/cilastatin?






2. Which drug(s) cause this reaction: G6PD hemolysis(8)?






3. For Warfarin What is the Onset of action






4. What is Ketoconazole specifically used for?






5. List the specific antidote for this toxin: Amphetamine






6. Adverse effects of Hydrochlorothiazide?






7. Acetazolamide - mechanism?






8. What organisms does Griseofulvin target?






9. What is Niclosamide used for?






10. Name the common Nucleoside Reverse Transcriptase Inhibitors






11. Describe first - order kinetics?






12. What is the mechanism of Leuprolide?






13. What is the mechanism of action of the H2 Blockers?






14. What drug is given for Pneumocystis carinii prophylaxis?






15. How can Vancomycin - induced 'Red Man Syndrome' be prevented?






16. What is action of insulin in the liver - in muscle - and in adipose tissue?






17. What are the clinical uses for 1st Generation Cephalosporins?






18. What are the clinical indications for Azole therapy?






19. Antiarrhythmic class IB- effects?






20. ADH antagonists - site of action?






21. What is treated with Chloroquine - Quinine - Mefloquine?






22. Name two classes of drugs for HIV therapy






23. MOA: Block DNA topoisomerases






24. For Warfarin What is the Duration of action






25. What is the mechanism of action of NSAIDs other than Aspirin?






26. List the mechanism - clinical use - & toxicity of Paclitaxel.






27. Name three ACE inhibitors?






28. What is the mechanism of action of Allopurinol used to treat chronic gout?






29. What type of patient should not take Misoprostol and why?






30. What are the clinical uses for 2nd Generation Cephalosporins?






31. Can Heparin be used during pregnancy?






32. List the mechanism - clinical use - & toxicity of 6 MP.






33. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






34. What populations are Floroquinolones contraindicated in? Why?






35. What are four thrombolytics?






36. What are five toxicities associated with Tacrolimus (FK506)?






37. Side effects of Isoniazid (INH)?






38. Verapamil has similar action to?






39. Resistance mechanisms for Tetracycline






40. What are common toxicities associated with Tetracyclines?

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41. What is the MOA for Vancomycin?






42. Which drug(s) cause this reaction: Cinchonism (2)?






43. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






44. What beta 2 agonist will help your 21yo Astma pt?






45. What are the major structural differences between Penicillin and Cephalosporin?






46. What drugs target anticholinesterase






47. What is are two clinical uses of Cyclosporine?






48. Which drug(s) cause this reaction: Anaphylaxis?






49. What are three types of antacids and the problems that can result from their overuse?






50. Which diuretics decrease urine Ca2+?