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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are five disadvantages of Oral Contraceptives (synthetic progestins - estrogen)?






2. Decrease Digitoxin dose in renal failure?






3. What is Imipenem always administered with?






4. How does dantrolene work?






5. What is the category of drug names ending in - terol (e.g. Albuterol)






6. What is the MOA of Isoniazid (INH)?






7. How is Chloramphenical used clinically?






8. What physiological effects was the Anes using Atropine to tx






9. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






10. What are three complications of Warfarin usage?






11. What is the receptor affinity and clinical use of isoproterenol?






12. What is the category of drug names ending in - oxin (e.g. Digoxin)






13. Which drug(s) cause this reaction: Fanconi's syndrome?






14. Ganciclovir associated toxicities?






15. What is the MOA for Amphotericin B?






16. What is the only depolarizing neuromuscular blocking agent?






17. Name four HMG- CoA reductase inhibitors.






18. Which drug increases Sys BP w/o affecting Pulse Pressure






19. When is HIV therapy initiated?






20. What is combination TMP- SMZ used to treat?






21. What are the clinical uses for Imipenem/cilastatin?






22. What are three toxicities of Leuprolied?






23. What microorganisms are clinical indications for Tetracycline therapy?

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24. Which drug(s) cause this reaction: Cardiac toxicity?






25. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






26. What type of neurological blockade would hexamethonium create?






27. What are two mechanisms of action of Propythiouracil?






28. List five common glucocorticoids.






29. Nifedipine has similar action to?






30. What is the effect of TCA's on the adrenergic nerve?






31. What are three types of antacids and the problems that can result from their overuse?






32. Name two LPL stimulators.






33. How are the HIV drugs used clinically?

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34. Digoxin v. Digitoxin: protein binding?






35. How can the toxic effects of TMP be ameliorated?






36. Which drug(s) cause this reaction: P450 inhibition(6)?






37. Resistance mechanisms for Chloramphenicol






38. What are common toxic side effects of Sulfonamides? (5)






39. What is the MOA of Imipenem?






40. Adverse effect of Nitroprusside?






41. Name two bile acid resins.






42. How do you treat coma in the ER (4)?






43. Describe Phase I metabolism in liver(3)?






44. Which cancer drugs work at the level of mRNA(2)?






45. Preferential action of the Ca2+ channel blockers at cardiac muscle?






46. Bretyllium - toxicity?






47. What are four unwanted effects of Clomiphene use?






48. How does a competitive antagonist effect an agonist?






49. How can Isoniazid (INH)- induced neurotoxicity be prevented?






50. List the mechanism - clinical use - & toxicity of Cisplatin.