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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Does Heparin have a long - medium - or short half life?






2. What are two types of drugs that interfere with the action of Sucralfate and why?






3. List the specific antidote for this toxin: Methemoglobin






4. Describe the MOA of Interferons (INF)






5. If a patient is given hexamethonium - What would happen to his/her heart rate?






6. How would you reverse the effect of a neuromuscular blocking agent?






7. What are three clinical uses of the Leuprolide?






8. What type of gout is treated with Allopurinol?






9. List five common glucocorticoids.






10. Isopoterenol was given to a patient with a developing AV block - why?






11. Which drug(s) cause this reaction: Torsade de pointes (2)?






12. Why would you give a drug like pancuronium or succinylcholine?






13. List some specifics of lead poisoning(4)?






14. What is the mechanism of action of the Sulfonylureas?






15. Which RT inhibitors cause a Rash?






16. Hydrochlorothiazide - toxicity? (hyperGLUC - plus others)






17. Mg+- clinical use?






18. Which drug(s) cause this reaction: Diabetes insipidus?






19. For Heparin What is the Mechanism of action






20. What is the clinical use for Penicillin?






21. Antimicrobial prophylaxis for Syphilis






22. Antiarrhythmic class IV- toxicity?






23. For Heparin What is the Onset of action






24. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






25. What class of drug is echothiophate? What is its indication?






26. When is Rifampin not used in combination with other drugs?






27. What microorganisms are clinical indications for Tetracycline therapy?

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28. List the mechanism - clinical use - & toxicity of Prednisone.

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29. Does Warfarin have a long - medium - or short half life?






30. Name several common Macrolides (3)






31. What is the mechanism of action of Clomiphene?






32. What is the MOA of Foscarnet?






33. List the specific antidote for this toxin: TPA & Streptokinase






34. What are the four conditions in Which Omeprazole - Lansoprazole is used?






35. What are four clinical uses of glucocorticoids?

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36. MOA: Block protein synthesis at 30s subunit






37. For Heparin What is the Duration of action






38. Name two organisms Vancomycin is commonly used for?






39. What is the mechanism of action of Ticlopidine - Clopidogrel






40. What is the difference between the affinity for beta receptors between albuterol/terbutaline and dantroline?






41. What are two mechanisms of action of Propythiouracil?






42. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






43. What populations are Floroquinolones contraindicated in? Why?






44. What is the category of drug names ending in - caine (e.g. Lidocaine)






45. Furosemide - clinical use?






46. What are the major structural differences between Penicillin and Cephalosporin?






47. What are four unwanted effects of Clomiphene use?






48. Which drug(s) cause this reaction: Gray baby syndrome?






49. What is a Ribavirin toxicity?






50. What is the mechanism of action of Heparin?