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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The MOA for Chloramphenicol is?






2. What is the clinical use for Sucralfate?






3. Which cancer drugs effect nuclear DNA (4)?






4. What is the category of drug names ending in - cycline (e.g. Tetracycline)






5. Which of these three drugs will cause a reflex bradycardia in your pt (Norepi - Epi - or Isoporterenol)






6. What is the clinical utility of cocaine?






7. What are two toxicities of the Glitazones?






8. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






9. Describe the MOA of Interferons (INF)






10. Name the common Nucleoside Reverse Transcriptase Inhibitors






11. Why are albuterol and terbutaline effective in tx of acute asthmatic attacks?






12. How would you reverse the effect of a neuromuscular blocking agent?






13. List the specific antidote for this toxin: Anticholinesterases (organophosphate.)






14. How are Interferons (INF) used clinically?

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15. Which drug(s) cause this reaction: Diabetes insipidus?






16. What are signs of Sildenafil (Viagra) toxicity?






17. Does Ampicillin or Amoxicillin have a greater oral bioavailability?






18. What microorganisms are clinical indications for Tetracycline therapy?

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19. What is a common drug interaction associated with Griseofulvin?






20. What microorganisms is Aztreonam not effective against?






21. What process does Zafirlukast interfere with?






22. What do Aminoglycosides require for uptake?






23. What are common toxicities associated with Macrolides? (4)






24. Describe Phase II metabolism in liver(3)?






25. What are Fluoroquinolones indicated for? (3)






26. How does dantrolene work?






27. What side effect of using atropine to induce pupillary dilation would you expect?






28. What microorganisms are Aminoglycosides ineffective against?






29. What are Polymyxins used for?






30. Antiarrhythmic class IV- toxicity?






31. What are the major toxic side effects of the Cephalosporins?






32. Adverse effects of Hydrochlorothiazide?






33. Preferential action of the Ca2+ channel blockers at vascular smooth muscle?






34. Furosemide - class and mechanism?






35. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






36. What are toxic side effects for Metronidazole?






37. Adverse effects of Loop Diuretics?






38. Antiarrhythmic class IA effects?






39. Adverse effects of Hydralazine?






40. What are nine findings of Iatrogenic Cushing's syndrome caused by glucocorticoid therapy?






41. What is an occasional side effect of Aztreonam?






42. Clinical use of Isoniazid (INH)?






43. Name the common Azoles






44. If a patient is given hexamethonium - What would happen to his/her heart rate?






45. Furosemide - toxicity? (OH DANG)






46. Are not penicillinase resistant






47. What is the category of drug names ending in - azol (e.g. Ketoconazole)






48. Beta Blockers - site of action?






49. Which diuretics increase urine K+?






50. What musculo - skeletal side effects in Adults are associated with Floroquinolones?