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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the MOA of Griseofulvin?






2. Adenosine - clinical use?






3. Which of epi - norepi - or isoproterenol results in bradycardia?






4. What are three complications of Warfarin usage?






5. How is Foscarnet used clinically?






6. What are two Alpha - glucosidase inhibitors?






7. What is the mechanism of action of the glucocorticoids?






8. What are four thrombolytics?






9. How do Sulfonamides act on bacteria?






10. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






11. What anticholinesterase crosses the blood - brain - barrier?






12. Name three Antiarrhythmic drugs in class IV.






13. What are the Anti - TB drugs?






14. List the mechanism - clinical use - & toxicity of Methotrexate.






15. Antiarrhythmic class II- toxicity?






16. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






17. Digoxin v. Digitoxin: half life?






18. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






19. What is the category of drug names ending in - azepam (e.g. Diazepam)






20. How can the t1/2 of INH be altered?






21. Ethacrynic Acid - mechanism?






22. Which diuretics decrease urine Ca2+?






23. List some specifics of lead poisoning(4)?






24. What are two conditions in Which COX-2 inhibitors might be used?






25. What is the MOA for Methicillin - Nafcillin - and Dicloxacillin?






26. MOA: Block nucleotide synthesis






27. Can Warfarin be used during pregnancy?






28. What is used to reverse the action of Heparin?






29. What are the clinical indications for bethanechol?






30. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






31. Which drug(s) cause this reaction: Osteoporosis (2)?






32. Which drug(s) cause this reaction: Atropine - like side effects?






33. What are the clinical indications for Azole therapy?






34. Adverse effects of ganglionic blockers?






35. What are the major toxic side effects of the Cephalosporins?






36. Why is there a drop in systolic - mean - and diastolic bp with infusion of isoproterenol?






37. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






38. How do you treat coma in the ER (4)?






39. What is the mechanism of action of Ticlopidine - Clopidogrel






40. List the specific antidote for this toxin: Heparin






41. Acetazolamide - mechanism?






42. Beta Blockers - CNS toxicity?






43. If a patient is given hexamethonium - What would happen to his/her heart rate?






44. What cholinomimetics might your pt be taking for his glaucoma






45. Ethacrynic Acid - clinical use?






46. For Heparin What is the Treatment for overdose






47. Which drug(s) cause this reaction: Focal to massive hepatic necrosis (4)?






48. What are common side effects of Protease Inhibitors?






49. What are two toxicities of the Sulfonylureas?






50. Why is reserpine effective in treating HTN?