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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do Sulfonamides act on bacteria?






2. What side effect of using atropine to induce pupillary dilation would you expect?






3. Are not penicillinase resistant






4. What are common serious side effects of Aminoglycosides and What are these associated with?






5. What type of neurological blockade would hexamethonium create?






6. Which individuals are predisposed to Sulfonamide - induced hemolysis?






7. What are three possible toxicities of NSAID usage?






8. Explain pH dependent urinary drug elimination?






9. What are the major structural differences between Penicillin and Cephalosporin?






10. Mannitol - mechanism?






11. How are Interferons (INF) used clinically?


12. Which drug(s) cause this reaction: Anaphylaxis?






13. Adverse effects of Guanethidine?






14. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






15. What is Imipenem always administered with?






16. Which RT inhibitor causes Megaloblastic Anemia?






17. Why is Cilastatin administered with Imipenem?






18. Ca2+ channel blockers - clinical use?






19. Adverse effects of Hydralazine?






20. What is the category of drug names ending in - azepam (e.g. Diazepam)






21. How is Amphotericin B administered for fungal meningitis?






22. What are two toxicities associated with Cyclosporine?






23. What is the MOA for Clindamycin?






24. Loop diuretics (furosemide)- site of action?






25. What is the effect of guanethidine on adrenergic NE release?






26. What is the mechanism of action of the Alpha - glucosidase inhibitors?






27. Acetazolamide - clinical uses?






28. How is Ganciclovir activated?






29. What conditions would you use dantrolene?






30. List the specific antidote for this toxin: Tricyclic antidepressants






31. Which drug(s) cause this reaction: Fanconi's syndrome?






32. Describe Phase I metabolism in liver(3)?






33. What additional side effects exist for Ampicillin?






34. Antiarrhythmic Class III- effects?






35. What parasites are treated with Pyrantel Pamoate (more specific)?






36. What are the clinical uses for Aztreonam?






37. What is the clinical use for Penicillin?






38. What is a Ribavirin toxicity?






39. What enzyme is responsible for the degredation of Ach






40. What are the clinical uses for 1st Generation Cephalosporins?






41. Hydrochlorothiazide - clinical use?






42. Mannitol - clinical use?






43. Name some common Sulfonamides (4)






44. Acetazolamide - toxicity?






45. List the mechanism - clinical use - & toxicity of Etoposide.






46. What is the formula for Clearance (CL)






47. Adverse effects of Hydrochlorothiazide?






48. Is resistant to penicillinase?






49. List the mechanism - clinical use - & toxicity of 6 MP.






50. The COX-2 inhibitors (celecoxib - rofecoxib) have similar side effects to the NSAIDs with What one exception?