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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Beta Blockers - BP?






2. What are two mechanisms of action of Propythiouracil?






3. Why is reserpine effective in treating HTN?






4. Why is pyridostigmine effective in the treatment of myasthenia gravis?






5. Ca2+ channel blockers - mechanism?






6. What is the MOA of Ganciclovir?






7. What is used to reverse the action of Heparin?






8. Why is carbachol and pilocarpine useful in treatment of glaucoma?






9. What are the four conditions in Which Omeprazole - Lansoprazole is used?






10. What is the mechanism of action of Allopurinol used to treat chronic gout?






11. Antiarrhythmic class II- toxicity?






12. Which diuretics decrease urine Ca2+?






13. What are three unwanted effects of Mifepristone?






14. Resistance mechanisms for Aminoglycosides






15. What is action of insulin in the liver - in muscle - and in adipose tissue?






16. What is the effect of guanethidine on adrenergic NE release?






17. What microorganisms are Aminoglycosides ineffective against?






18. What organism is Imipenem/cilastatin the Drug of Choice for?






19. Antiarrhythmic class IC- effects?






20. What are the side effects of Rifampin?






21. Name four Antiarrhythmic drugs in class IA.






22. What are two clinical uses of Azathioprine?






23. Antiarrhythmic class II- mechanism?






24. Esmolol - short or long acting?






25. What is the lab value used to monitor the effectiveness of Heparin therapy?






26. Which drug(s) cause this reaction: Gray baby syndrome?






27. What is a prerequisite for Acyclovir activation?






28. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






29. What is the mechanism of Leuprolide?






30. What are the phases of succinylcholine neuromuscular blockade?






31. What is the mechanism of action of the thrombolytics?






32. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






33. What cholinergic inhibitor acts by directly inhibiting Ach release at the presynaptic terminal






34. Resistance mechanisms for Tetracycline






35. Adverse effects of Guanethidine?






36. What is the MOA of Aztreonam?






37. Triamterene and amiloride - mechanism?






38. Acetazolamide - site of action?






39. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






40. List the mechanism - clinical use - & toxicity of Cisplatin.






41. Does Heparin have a long - medium - or short half life?






42. Which drug(s) cause this reaction: Pseudomembranous colitis?






43. What are five advantages of Oral Contraceptives (synthetic progestins - estrogen)?






44. Name three Antiarrhythmic drugs in class IB.






45. For Heparin What is the Lab value to monitor






46. What are the nondepolarizing neuromuscular blocking drugs?






47. What type of gout is treated with Probenacid?






48. Preferential action of the Ca2+ channel blockers at cardiac muscle?






49. K+ sparing diuretics - clinical use?






50. What is the difference in receptor affinity of epinephrine at low doses? High doses?

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