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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do you treat coma in the ER (4)?






2. Adverse effects of Captopril?






3. What is the MOA of Ribavirin?






4. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






5. What is an occasional side effect of Aztreonam?






6. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






7. ________ ae not resistant to penicillinase - - but they are less susceptible than the other Beta lactams






8. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






9. Ethacrynic Acid - mechanism?






10. Antimicrobial prophylaxis for a history of recurrent UTIs






11. Hydrochlorothiazide - mechanism?






12. What is the category of drug names ending in - tropin (e.g. Somatotropin)






13. What enzyme does Zileuton inhibit?






14. What are three possible toxicities of NSAID usage?






15. Antiarrhythmic class IB- effects?






16. Resistance mechanisms for Aminoglycosides






17. When is HIV therapy initiated?






18. What is the mecanism of action of Sucralfate?






19. Antimicrobial prophylaxis for Syphilis






20. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






21. What is the main clinical use for the thrombolytics?






22. Guanethidine enhances the release of Norepi?






23. What is the clinical use for Sildenafil (Viagra)?






24. Ca2+ channel blockers - toxicity?






25. What microorganisms is Aztreonam not effective against?






26. What is the mechanism of action of the H2 Blockers?






27. Furosemide increases the excretion of What ion?






28. What is an acronym to remember Anti - TB drugs?






29. What are three possible complications of Heparin therapy?






30. How can the t1/2 of INH be altered?






31. Why is pyridostigmine effective in the treatment of myasthenia gravis?






32. List the specific antidote for this toxin: Cyanide






33. K+- clinical use?






34. What is Nifurtimox administered for?

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35. What are are the Sulfonylureas (general description) and What is their use?






36. Name five Antiarrhythmic drugs in class II?






37. What is the lab value used to monitor the effectiveness of Warfarin therapy?






38. What type of gout is treated with Colchicine?






39. How does resistance to Vancomycin occur?






40. Acetazolamide - mechanism?






41. Steady state concentration is reached in __ number of half - lifes






42. What type of gout is treated with Probenacid?






43. Why would you give a drug like pancuronium or succinylcholine?






44. What is the MOA for Trimethoprim (TMP)?






45. How is Chloramphenical used clinically?






46. MOA: Block protein synthesis at 50s subunit






47. What drug is given for Pneumocystis carinii prophylaxis?






48. What are common toxic side effects of Sulfonamides? (5)






49. What are three complications of Warfarin usage?






50. Acetazolamide - clinical uses?