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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How can the toxic effects of TMP be ameliorated?






2. Hydralazine - toxicity?






3. Why would you give a drug like pancuronium or succinylcholine?






4. Adverse effects of Captopril?






5. Which RT inhibitors cause Lactic Acidosis?






6. ACE inhibitors - clinical use?






7. What is the MOA for Vancomycin?






8. Which drug(s) cause this reaction: Aplastic anemia (5)?






9. Secretion of What drug is inhibited by Probenacid used to treat chronic gout?






10. Name the common Aminoglycosides (5)






11. What type of gout is treated with Allopurinol?






12. Antimicrobial prophylaxis for Syphilis






13. How would hemicholinium treatment affect cholinergic neurons?






14. What are common side effects of RT Inhibitors?






15. Name several common Macrolides (3)






16. List the specific antidote for this toxin: Arsenic (all heavy metals)






17. Mannitol - clinical use?






18. A group of pts are rushed into the ER complaining of excessive sweating - tearing - salivation - HA - N and V - muscle twitching - difficulty breathing and diarrhea. What drug would be the most effective immediate tx






19. Mnemonic for Foscarnet?






20. Why would you use pralidoxime after exposure to an organophosphate?






21. Ibutilide - toxicity?






22. List the mechanism - clinical use - & toxicity of 5 FU.






23. What is the category of drug names ending in - azepam (e.g. Diazepam)






24. What is the lab value used to monitor the effectiveness of Warfarin therapy?






25. What are two Glitazones?






26. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






27. What is a common drug interaction associated with Griseofulvin?






28. What would be the effect on blood pressure with infusion of the alpha -2 agonist clonidine?






29. What neurotransmitter does Amantadine affect? How does it influence this NT?






30. How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax - P.ovale) treated?






31. Explain differences between full and partial agonists(2).






32. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






33. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






34. What is the clinical utility of cocaine?






35. What is the effect of TCA's on the adrenergic nerve?






36. What is action of insulin in the liver - in muscle - and in adipose tissue?






37. Describe Phase II metabolism in liver(3)?






38. Ca2+ channel blockers - toxicity?






39. Quinidine - toxicity?






40. What is the clinical utility of clonidine?






41. Name three K+ sparing diuretics?






42. What is the most common cause of Pt noncompliance with Macrolides?






43. What are four Sulfonylureas?






44. MOA of Succinylcholine






45. Name four HMG- CoA reductase inhibitors.






46. Which drug(s) cause this reaction: Torsade de pointes (2)?






47. K+ sparing diuretics - clinical use?






48. Name the common Fluoroquinolones (6)






49. Resistance mechanisms for Sulfonamides






50. Adverse effects of Losartan?