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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. When is Rifampin not used in combination with other drugs?






2. For Warfarin What is the Site of action






3. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






4. ACE inhibitors - mechanism?






5. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






6. Mannitol - contraindications?






7. What are four H2 Blockers?






8. For Heparin What is the Structure






9. Which drug(s) cause this reaction: Cardiac toxicity?






10. Which drug(s) cause this reaction: Gynecomastia (6)?






11. Ganciclovir associated toxicities?






12. Mg+- clinical use?






13. List the specific antidote for this toxin: Arsenic (all heavy metals)






14. Name five Antiarrhythmic drugs in class II?






15. What are five possible toxic effects of Aspirin therapy?

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16. What is the receptor affinity and clinical use of isoproterenol?






17. What process does Zafirlukast interfere with?






18. How can Vancomycin - induced 'Red Man Syndrome' be prevented?






19. What are three possible toxicities of NSAID usage?






20. How is Amphotericin B used clinically?






21. What is the category of drug names ending in - tropin (e.g. Somatotropin)






22. Adverse effects of Loop Diuretics?






23. What are the Macrolides used for clinically?






24. Which diuretics cause alkalosis?






25. What is the MOA of Aztreonam?






26. Name three Antiarrhythmic drugs in class IV.






27. Verapamil has similar action to?






28. What is the category - method of use - and adverse effects of Salmeterol in Asthma treatment?






29. What are the major toxic side effects of Imipenem/cilastatin?






30. Name four HMG- CoA reductase inhibitors.






31. How can the toxic effects of TMP be ameliorated?






32. What are Polymyxins used for?






33. Why does atropine dilate the pupil?






34. What is the clinical use for Sucralfate?






35. What sympathomimetic would you not prescribe for hypotension in a pt with renal artery sclerosis.






36. ADH antagonists - site of action?






37. Digoxin v. Digitoxin: half life?






38. A group of pts are rushed into the ER complaining of excessive sweating - tearing - salivation - HA - N and V - muscle twitching - difficulty breathing and diarrhea. What drug would be the most effective immediate tx






39. What is the mecanism of action of Sucralfate?






40. Which drug increases Sys BP w/o affecting Pulse Pressure






41. Adverse effects of beta - blockers?






42. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?






43. What type of neurological blockade would hexamethonium create?






44. What is the clinical use for Nystatin?






45. What neurotransmitter does Amantadine affect? How does it influence this NT?






46. What type of gout is treated with Colchicine?






47. How are the HIV drugs used clinically?

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48. What microorganisms are Aminoglycosides ineffective against?






49. What drug is used to diagnose myasthenia gravis?






50. What musculo - skeletal side effects in Adults are associated with Floroquinolones?







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