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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the mechanism of action of Misoprostol?






2. Ryanodine - site of action?






3. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






4. Antiarrhythmic class IV- clinical use?






5. Antiarrhythmic class II- toxicity?






6. What are five possible toxic effects of Aspirin therapy?

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7. What conditions are treated with Metronidazole?






8. Acetazolamide causes?

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9. What is a possible toxicity of Alpha - glucosidase inhibitors used in type -2 diabetes?






10. What is a possible result of overdose of Acetaminophen?






11. For Warfarin What is the Route of administration






12. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






13. Are not penicillinase resistant






14. What is the MOA of Foscarnet?






15. What is the MOA for the Fluoroquinolones?






16. Which drug(s) cause this reaction: Cough?






17. Which drug(s) cause this reaction: Oto and Nephrotoxicity (3)?






18. What are the clinical uses for 1st Generation Cephalosporins?






19. List five common glucocorticoids.






20. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






21. Describe the MOA of Interferons (INF)






22. What is the mechanism of action of Aspirin?






23. How does resistance to Vancomycin occur?






24. What is the mechanism of action of the thrombolytics?






25. Which diuretics decrease urine Ca2+?






26. Decrease Digitoxin dose in renal failure?






27. What are toxic side effects for Metronidazole?






28. Which drug(s) cause this reaction: Cutaneous flushing (4)?






29. What are the classic symptoms of cholinesterase inhibitor poisoning (parathion or other organophosphates)?






30. What is the clincial use for Misoprostol?






31. What side effect of using atropine to induce pupillary dilation would you expect?






32. What is the difference between the affinity for beta receptors between albuterol/terbutaline and dantroline?






33. What is the clinical use for Warfarin?






34. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






35. What is a sign of toxicity with the use of thrombolytics?






36. Antimicrobial prophylaxis for PCP






37. What is the clinical use for Ampicillin and Amoxicillin?






38. Verapamil has similar action to?






39. Antiarrhythmic class IV- primary site of action?






40. What is the mechanism of action and clinical use of the antiandrogens Ketoconazole and Spironolactone?






41. Oral Penicillin






42. What is the MOA for Rifampin?






43. What type of gout is treated with Probenacid?






44. What is the memory key for Isoniazid (INH) toxicity?






45. List the mechanism - clinical use - & toxicity of Paclitaxel.






46. Classes of antihypertensive drugs?






47. What cholinergic inhibitor acts by directly inhibiting Ach release at the presynaptic terminal






48. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






49. If a patient is given hexamethonium - What would happen to his/her heart rate?






50. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?