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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Amprotericin B ___________ the BBB






2. IV Penicillin






3. What are three clinical uses of the NSAIDs?






4. Mannitol - clinical use?






5. What is the effect of norepinephrine on bp and pulse pressure?






6. What are the products and their toxicities of the metabolism of Ethylene Glycol by / alcohol dehydrogenase?






7. How do you calculate maintenance dose?






8. While at a tail gait party - you bite into a sandwich that a yellow jacket is also enjoying. Knowing your allergy to this creature - What should you do?






9. What is the MOA for the Tetracyclines?






10. Which drug(s) cause this reaction: Photosensitivity(3)?






11. Adverse effects of Minoxidil?






12. For Heparin What is the Lab value to monitor






13. What is the most common cause of Pt noncompliance with Macrolides?






14. Resistance mechanisms for Aminoglycosides






15. What is the memory key for Metronidazole's clinical uses?






16. What is the mechanism of action of Colchicine used to treat acute gout?






17. For Heparin What is the Ability to inhibit coagulation in vitro






18. What is the loading dose formula?






19. Common toxicities associated with Fluoroquinolones?






20. What cholinomimetics might your pt be taking for his glaucoma






21. Adverse effects of ganglionic blockers?






22. What is the MOA of Griseofulvin?






23. Which drug(s) cause this reaction: Gingival hyperplasia?






24. What is the major side effect for Ampicillin and Amoxicillin?






25. What is the mechanism of Azathioprine?






26. Which RT inhibitor causes Megaloblastic Anemia?






27. What are the clinical indications for Azole therapy?






28. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






29. Acetazolamide - mechanism?






30. Which drug(s) cause this reaction: Neuro and Nephrotoxic?






31. Hydralazine - class and mechanism?






32. Preferential action of the Ca2+ channel blockers at vascular smooth muscle?






33. Ca2+ channel blockers - clinical use?






34. Ibutilide - toxicity?






35. How would you treat African Trypanosomiasis (sleeping sickness)?






36. What would be the effect on blood pressure with infusion of the alpha -2 agonist clonidine?






37. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






38. Furosemide - clinical use?






39. K+ sparing diuretics - toxicity?






40. What is the mechanism of action of Omeprazole - Lansoprazole?






41. ACE inhibitors - toxicity?






42. Classes of antihypertensive drugs?






43. For Warfarin What is the Site of action






44. How can the toxic effects of TMP be ameliorated?






45. What is the mechanism of action of the glucocorticoids?






46. What are the clinical indications for bethanechol?






47. How is Chloramphenical used clinically?






48. Name common Polymyxins






49. How do spare receptors effect the Km?






50. Antimicrobial prophylaxis for Syphilis