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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are two toxicities of the Sulfonylureas?






2. Common side effects associated with Clindamycin include?






3. What are Fluoroquinolones indicated for? (3)






4. Which drug(s) cause this reaction: Tendonitis and rupture?






5. What enzyme is responsible for the degredation of Ach






6. What drug is used during the pregnancy of an HIV+ mother? - Why?






7. How can the t1/2 of INH be altered?






8. What physiological effects was the Anes using Atropine to tx






9. What is a sign of toxicity with the use of thrombolytics?






10. Name four HMG- CoA reductase inhibitors.






11. What parasitic condition is treated with Ivermectin?

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12. List the mechanism - clinical use - & toxicity of Tamoxifen.






13. List the mechanism - clinical use - & toxicity of Etoposide.






14. Your patient wants an effective drug to treat his motion sickness - What would you prescribe






15. Which drug(s) cause this reaction: Gray baby syndrome?






16. What are three clinical uses of the Leuprolide?






17. What are toxic side effects for Metronidazole?






18. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






19. MOA: Block peptidoglycan synthesis






20. For Heparin What is the Route of administration






21. Ca2+ channel blockers - site of action?






22. What antimicrobial class is Aztreonam syngergestic with?






23. Why is reserpine effective in treating HTN?






24. Hydrochlorothiazide - toxicity? (hyperGLUC - plus others)






25. How is Griseofulvin used clinically?






26. Name three Antiarrhythmic drugs in class IB.






27. How does botulinum toxin result in respiratory arrest?






28. Why is Cilastatin administered with Imipenem?






29. What is the major side effect for Carbenicillin - Piperacillin - and Ticarcillin?






30. Decrease Digoxin dose in renal failure?






31. What is the formula for Clearance (CL)






32. For Warfarin What is the Ability to inhibit coagulation in vitro






33. What are the four conditions in Which Omeprazole - Lansoprazole is used?






34. Antiarrhythmic Class III- effects?






35. MOA for Penicillin (3 answers)?






36. What is the MOA for the Cephalosporins?






37. Does Warfarin have a long - medium - or short half life?






38. Which drug(s) cause this reaction: Gynecomastia (6)?






39. What is the MOA for Amphotericin B?






40. Are not penicillinase resistant






41. Name the common Nucleoside Reverse Transcriptase Inhibitors






42. Common toxicities associated with Griseofulvin?






43. What are four clinical uses of glucocorticoids?

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44. What are the clinical indications for neostigmine?






45. What is the category - desired effect - and period of use of albuterol in the treatment of Asthma?






46. Ca2+ channel blockers - mechanism?






47. What is the MOA of Griseofulvin?






48. What is the clinical use for Nystatin?






49. ACE inhibitors - clinical use?






50. What is the category of drug names ending in - azepam (e.g. Diazepam)