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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which drug(s) cause this reaction: Gray baby syndrome?






2. Adverse effects of ganglionic blockers?






3. What are the clinical uses for 3rd Generation Cephalosporins?






4. What organisms does Griseofulvin target?






5. What are Aminoglycosides used for clinically?






6. Common side effects associated with Clindamycin include?






7. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






8. What is the mechanism of action of the thrombolytics?






9. What are the major toxic side effects of the Cephalosporins?






10. Name some common Tetracyclines (4)






11. What is the memory key for the action of Sildenafil (Viagra)?






12. How are Interferons (INF) used clinically?

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13. How is Vancomycin used clinically?






14. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






15. What are the Macrolides used for clinically?






16. What is Clindamycin used for clinically?






17. What is the clinical use for Penicillin?






18. Common toxicities associated with Griseofulvin?






19. What is the specific clinical use of Indomethacin in neonates?






20. Decrease Digitoxin dose in renal failure?






21. What is the lab value used to monitor the effectiveness of Warfarin therapy?






22. For Heparin What is the Mechanism of action






23. What is the mechanism of action of NSAIDs other than Aspirin?






24. What type of gout is treated with Allopurinol?






25. How are the HIV drugs used clinically?

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26. What is the category of drug names ending in - tidine (e.g. Cimetidine)






27. Adverse effects of Hydrochlorothiazide?






28. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






29. What is the chemical name for Ganciclovir?






30. What is the MOA for Nystatin?






31. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






32. Ca2+ sensitizers'- site of action?






33. What is the MOA for Amphotericin B?






34. What side effect of using atropine to induce pupillary dilation would you expect?






35. Spironolactone - mechanism?






36. K+ sparing diuretics - toxicity?






37. How do you treat coma in the ER (4)?






38. Beta Blockers - CV toxicity?






39. List the specific antidote for this toxin: Anticholinesterases (organophosphate.)






40. What conditions are treated with Metronidazole?






41. List the mechanism - clinical use - & toxicity of 5 FU.






42. Why is pyridostigmine effective in the treatment of myasthenia gravis?






43. What are the nondepolarizing neuromuscular blocking drugs?






44. What class of drug is echothiophate? What is its indication?






45. MOA: Block nucleotide synthesis






46. Amprotericin B ___________ the BBB






47. Which diuretics increase urine Ca2+?






48. Toxic effects of TMP include?






49. Why are albuterol and terbutaline effective in tx of acute asthmatic attacks?






50. What are the clinical uses for Ticlopidine - Clopidogrel?







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