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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the clinical utility of cocaine?






2. What is the MOA for Trimethoprim (TMP)?






3. What are five advantages of Oral Contraceptives (synthetic progestins - estrogen)?






4. Secretion of What drug is inhibited by Probenacid used to treat chronic gout?






5. How is Acyclovir used clinically?






6. Spironolactone - mechanism?






7. What are Aminoglycosides synergistic with?






8. How is Amantadine used clinically?

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9. What is a possible result of overdose of Acetaminophen?






10. Explain pH dependent urinary drug elimination?






11. List the mechanism - clinical use - & toxicity of Tamoxifen.






12. List the specific antidote for this toxin: Opioids






13. Digitalis - site of action?






14. What is the MOA of Ribavirin?






15. Hydrochlorothiazide - mechanism?






16. Antimicrobial prophylaxis for a history of recurrent UTIs






17. Ca2+ sensitizers'- site of action?






18. Toxic effects of TMP include?






19. How is Amphotericin B administered for fungal meningitis?






20. List the mechanism - clinical use - & toxicity of Vincristine.

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21. Amprotericin B ___________ the BBB






22. Aztreonam ________ to penicillinase






23. For Heparin What is the Mechanism of action






24. What is an acronym to remember Anti - TB drugs?






25. Name three ACE inhibitors?






26. Adverse effects of Hydrochlorothiazide?






27. Which of epi - norepi - or isoproterenol results in bradycardia?






28. Cautions When using Amiodarone?






29. What is the MOA for the Cephalosporins?






30. What effect would atropine have on the preganglionic sympathetic activation of sweat glands? Would this person sweat?






31. Antiarrhythmic class II- effects?






32. What is the memory key involving the '4 R's of Rifampin?'






33. What are are the Sulfonylureas (general description) and What is their use?






34. What are three types of antacids and the problems that can result from their overuse?






35. What is Niclosamide used for?






36. What are common side effects of RT Inhibitors?






37. Mg+- clinical use?






38. List the specific antidote for this toxin: Antimuscarinic (anticholinergic)






39. What is the clinical utility of clonidine?






40. What is the lab value used to monitor the effectiveness of Warfarin therapy?






41. List the mechanism - clinical use - & toxicity of 6 MP.






42. Foscarnet does not require activation by a...






43. What is the specific clinical use of Indomethacin in neonates?






44. List the specific antidote for this toxin: Amphetamine






45. Which drug(s) cause this reaction: Osteoporosis (2)?






46. How is Vancomycin used clinically?






47. List the specific antidote for this toxin: Cyanide






48. ACE inhibitors - clinical use?






49. What is the mechanism of action of Mifepristone (RU486)?






50. What anticholinesterase crosses the blood - brain - barrier?






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