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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. For Warfarin What is the Lab value to monitor






2. Which drug(s) cause this reaction: Focal to massive hepatic necrosis (4)?






3. What is the mechanism of action of Ticlopidine - Clopidogrel






4. Name the common Aminoglycosides (5)






5. What populations are Floroquinolones contraindicated in? Why?






6. For Heparin What is the Onset of action






7. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






8. What are nine findings of Iatrogenic Cushing's syndrome caused by glucocorticoid therapy?






9. Explain differences between full and partial agonists(2).






10. Describe first - order kinetics?






11. Ryanodine - site of action?






12. What is the mecanism of action of Sucralfate?






13. ________ ae not resistant to penicillinase - - but they are less susceptible than the other Beta lactams






14. In What population does Gray Baby Syndrome occur? Why?






15. Which drug(s) cause this reaction: Cardiac toxicity?






16. What is the most common cause of Pt noncompliance with Macrolides?






17. Adenosine - clinical use?






18. What are four H2 Blockers?






19. What antimicrobial class is Aztreonam syngergestic with?






20. What is the MOA for the Macrolides?






21. Would blockade of muscarininc receptors in the bladder be useful in treating urinary retention?






22. Is toxicity rare or common whith Cromolyn used in Asthma prevention?






23. What is the MOA of Aztreonam?






24. Why does NE result in bradycardia?






25. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






26. How is Amphotericin B administered for fungal meningitis?






27. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






28. What are four Sulfonylureas?






29. List the specific antidote for this toxin: Antimuscarinic (anticholinergic)






30. What is the major toxic side effect of Penicillin?






31. Quinidine - toxicity?






32. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






33. How is Griseofulvin used clinically?






34. What is the memory key for the effect of aluminum hydroxide overuse?






35. Thiazides - site of action?






36. What is the possible mechanism and effect of Metformin in treating diabetes?






37. Which drug(s) cause this reaction: Hot flashes?






38. What are the clinical uses for Ticlopidine - Clopidogrel?






39. A group of pts are rushed into the ER complaining of excessive sweating - tearing - salivation - HA - N and V - muscle twitching - difficulty breathing and diarrhea. What drug would be the most effective immediate tx






40. What are two indirect acting adrenergic agonists?






41. How does botulinum toxin result in respiratory arrest?






42. List the specific antidote for this toxin: Warfarin






43. Which cancer drugs inhibit nucleotide synthesis(3)?






44. MOA: Block cell wall synthesis by inhib. Peptidoglycan cross - linking (7)






45. Antiarrhythmic class IB- clinical uses?






46. What are three toxicities of Leuprolied?






47. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






48. What reversal agent could a Anes give to reverse the effects of Atropine






49. List the mechanism - clinical use - & toxicity of Paclitaxel.






50. Which drug(s) cause this reaction: Oto and Nephrotoxicity (3)?