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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the specific clinical use of Indomethacin in neonates?






2. Adverse effects of Minoxidil?






3. What are the classic symptoms of cholinesterase inhibitor poisoning (parathion or other organophosphates)?






4. List the mechanism - clinical use - & toxicity of Vincristine.

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5. K+ sparing diuretics - clinical use?






6. List the specific antidote for this toxin: Tricyclic antidepressants






7. What type of neurological blockade would hexamethonium create?






8. Which diuretics decrease urine Ca2+?






9. Does Warfarin have a long - medium - or short half life?






10. Which cancer drugs work at the level of proteins(2)?






11. The MOA for Chloramphenicol is?






12. Which drug(s) cause this reaction: Hot flashes?






13. Which RT inhibitors cause Lactic Acidosis?






14. What are three complications of Warfarin usage?






15. For Warfarin What is the Ability to inhibit coagulation in vitro






16. What is the mechanism of action of Clomiphene?






17. What microorganisms are clinical indications for Tetracycline therapy?

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18. What is the clinical use for Penicillin?






19. A group of pts are rushed into the ER complaining of excessive sweating - tearing - salivation - HA - N and V - muscle twitching - difficulty breathing and diarrhea. What drug would be the most effective immediate tx






20. For Warfarin What is the Lab value to monitor






21. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






22. Common toxicities associated with Fluoroquinolones?






23. What cholinergic inhibitor acts by directly inhibiting Ach release at the presynaptic terminal






24. What is the MOA of Ribavirin?






25. Which antimuscarinic agents are used in producing mydriasis and cycloplegia?






26. Cautions When using Amiodarone?






27. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






28. Furosemide increases the excretion of What ion?






29. Name four HMG- CoA reductase inhibitors.






30. Triamterene and amiloride - mechanism?






31. What are nine findings of Iatrogenic Cushing's syndrome caused by glucocorticoid therapy?






32. Which drug(s) cause this reaction: Tendonitis and rupture?






33. What is the memory key for the effect of magnesium hydroxide overuse?






34. What drug is given for Pneumocystis carinii prophylaxis?






35. What is the MOA of Ganciclovir?






36. What is Niclosamide used for?






37. Adverse effects of Prazosin?






38. For Heparin What is the Ability to inhibit coagulation in vitro






39. Beta Blockers - BP?






40. Digoxin v. Digitoxin: excretion?






41. What neurotransmitter does Amantadine affect? How does it influence this NT?






42. Which drug(s) cause this reaction: Aplastic anemia (5)?






43. Why is reserpine effective in treating HTN?






44. What is the mechanism of action of Cyclosporine?






45. What are the clinical uses for 1st Generation Cephalosporins?






46. What is a sign of toxicity with the use of thrombolytics?






47. Which receptors does phenylephrine act upon?






48. Beta Blockers - site of action?






49. What cholinomimetics might your pt be taking for his glaucoma






50. What conditions would you use dantrolene?