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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are five advantages of Oral Contraceptives (synthetic progestins - estrogen)?






2. Isopoterenol was given to a patient with a developing AV block - why?






3. MOA: Block protein synthesis at 50s subunit






4. What is the possible mechanism and effect of Metformin in treating diabetes?






5. Antiarrhythmic class IV- clinical use?






6. What are are the Sulfonylureas (general description) and What is their use?






7. For Warfarin What is the Lab value to monitor






8. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






9. Name five Antiarrhythmic drugs in class II?






10. What musculo - skeletal side effects in Adults are associated with Floroquinolones?






11. Why is reserpine effective in treating HTN?






12. What is the clinical use for Clomiphene?






13. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






14. What is the MOA of Imipenem?






15. How do you calculate maintenance dose?






16. Name the common Nucleoside Reverse Transcriptase Inhibitors






17. Which drug(s) cause this reaction: Pseudomembranous colitis?






18. Name three Antiarrhythmic drugs in class IC.






19. Digoxin v. Digitoxin: half life?






20. What are two toxicities associated with Cyclosporine?






21. What microorganisms are clinical indications for Tetracycline therapy?

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22. Which drug(s) cause this reaction: Cinchonism (2)?






23. Which drug(s) cause this reaction: Tardive dyskinesia?






24. What are Fluoroquinolones indicated for? (3)






25. Esmolol - short or long acting?






26. Which diuretics increase urine K+?






27. What is the MOA for Amphotericin B?






28. What drug is used to diagnose myasthenia gravis?






29. What are major side effects of Methicillin - Nafcillin - and Dicloxacillin?






30. What are two processes Corticosteroids inhibit leading to decreased inflammation?






31. What are common toxicities related to Vancomycin therapy?

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32. Which RT inhibitors cause a Rash?






33. How would you reverse the effect of a neuromuscular blocking agent?






34. A common side effects of Interferon (INF) treatment is?






35. What is Imipenem always administered with?






36. Beta Blockers - BP?






37. What anticholinesterase crosses the blood - brain - barrier?






38. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






39. What is the only depolarizing neuromuscular blocking agent?






40. How does dantrolene work?






41. What are common toxicities associated with Tetracyclines?

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42. Which Aminoglycoside is used for Bowel Surgery ?






43. What is the formula for Volume of distribution (Vd)






44. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






45. Which Tetracycline is used in patients with renal failure? / Why?






46. Name two organisms Vancomycin is commonly used for?






47. Decrease Digitoxin dose in renal failure?






48. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






49. How is Foscarnet used clinically?






50. Which receptors does phenylephrine act upon?