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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name four HMG- CoA reductase inhibitors.






2. Which drug(s) cause this reaction: Tardive dyskinesia?






3. What is the most common cause of Pt noncompliance with Macrolides?






4. List the specific antidote for this toxin: Acetaminophen






5. Hydrochlorothiazide - clinical use?






6. How are Sulfonamides employed clinically?






7. What patients are at risk for life threatening hypotension When taking Sildenafil (Viagra)?






8. What are common toxicities associated with Tetracyclines?

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9. Antiarrhythmic class IC- effects?






10. Antiarrhythmic class IV- effects?






11. What type of patient should not take Misoprostol and why?






12. What is the mechanism of action of Colchicine used to treat acute gout?






13. Antiarrhythmic class II- mechanism?






14. Which drug(s) cause this reaction: Extrapyramidal side effects (3)?






15. List the specific antidote for this toxin: Heparin






16. What are four clinical activities of Aspirin?






17. List the specific antidote for this toxin: Carbon monoxide






18. What antimuscarinic drug is useful for the tx of asthma






19. What is the category of drug names ending in - azol (e.g. Ketoconazole)






20. How do Sulfonamides act on bacteria?






21. What are three types of antacids and the problems that can result from their overuse?






22. Describe Phase II metabolism in liver(3)?






23. What is the mechanism of action of Omeprazole - Lansoprazole?






24. In coma situations you rule out What (7)?

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25. What physiological effects was the Anes using Atropine to tx






26. What is the memory aid for subunit distribution of ribosomal inhibitors?

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27. Which Aminoglycoside is used for Bowel Surgery ?






28. What is the major toxic side effect of Penicillin?






29. How does angiotensin II affect NE release?






30. What are the side effects of Rifampin?






31. What is the memory key for the effect of aluminum hydroxide overuse?






32. Clinical use of Isoniazid (INH)?






33. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






34. MOA: Block mRNA synthesis






35. What are the nondepolarizing neuromuscular blocking drugs?






36. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






37. Mnemonic for Foscarnet?






38. Mannitol - clinical use?






39. Which drug(s) cause this reaction: G6PD hemolysis(8)?






40. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






41. What side effect of using atropine to induce pupillary dilation would you expect?






42. What parasitic condition is treated with Ivermectin?

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43. Toxicities associated with Acyclovir?






44. What is the mechanism of action of Heparin?






45. What are three possible complications of Heparin therapy?






46. What is the MOA for Trimethoprim (TMP)?






47. If a patient is given hexamethonium - What would happen to his/her heart rate?






48. Acetaminophen has What two clinical uses and lacks What one clinical use of the NSAIDs?






49. What is the memory key for Isoniazid (INH) toxicity?






50. Mannitol - toxicity?