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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the effect of norepinephrine on bp and pulse pressure?






2. Name the common Non - Nucleoside Reverse Transcriptase Inhibitors






3. Bretyllium - toxicity?






4. What are the clinical uses for Aztreonam?






5. What is the MOA for the Fluoroquinolones?






6. Name some common Sulfonamides (4)






7. What is the effect of TCA's on the adrenergic nerve?






8. List the specific antidote for this toxin: Methanol & Ethylene glycol






9. Cocaine casues vasoconstriction and local anesthesia by What mechanism






10. What is the category of drug names ending in - phylline (e.g. Theophylline)






11. What are the products and their toxicities of the metabolism of Ethylene Glycol by / alcohol dehydrogenase?






12. What is the category of drug names ending in - azepam (e.g. Diazepam)






13. Which drug(s) cause this reaction: Aplastic anemia (5)?






14. For Heparin What is the Ability to inhibit coagulation in vitro






15. What are the clinical indications for bethanechol?






16. Spironolactone - mechanism?






17. Which drug(s) cause this reaction: Tendonitis and rupture?






18. Adverse effects of Clonidine?






19. List the specific antidote for this toxin: Digitalis






20. Common toxicities associated with Griseofulvin?






21. List the mechanism - clinical use - & toxicity of 6 MP.






22. What are four thrombolytics?






23. Which diuretics increase urine Ca2+?






24. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






25. What is the effect of the Glitazones in diabetes treatment?






26. What is the category of drug names ending in - operidol (e.g. Haloperidol)






27. What is the category of drug names ending in - zosin (e.g. Prazosin)






28. Resistance mechanisms for Cephalosporins/Penicillins






29. What anticholinesterase crosses the blood - brain - barrier?






30. What is the only depolarizing neuromuscular blocking agent?






31. List the specific antidote for this toxin: Methemoglobin






32. How are Sulfonamides employed clinically?






33. What is the MOA of Aztreonam?






34. List the mechanism - clinical use - & toxicity of Prednisone.

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35. MOA: Block peptidoglycan synthesis






36. Why would you use pralidoxime after exposure to an organophosphate?






37. List the specific antidote for this toxin: Arsenic (all heavy metals)






38. Mannitol - site of action?






39. What are five advantages of Oral Contraceptives (synthetic progestins - estrogen)?






40. Antiarrhythmic class IV- primary site of action?






41. For Heparin What is the Onset of action






42. Furosemide - class and mechanism?






43. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






44. Which drug(s) cause this reaction: Diabetes insipidus?






45. How is Leishmaniasis treated?






46. How is Amphotericin B administered for fungal meningitis?






47. When is HIV therapy initiated?






48. Which diuretics decrease urine Ca2+?






49. What drug is given for Pneumocystis carinii prophylaxis?






50. While at a tail gait party - you bite into a sandwich that a yellow jacket is also enjoying. Knowing your allergy to this creature - What should you do?






Can you answer 50 questions in 15 minutes?



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