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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Are not penicillinase resistant






2. What beta 2 agonist will help your 21yo Astma pt?






3. What is the MOA of Aztreonam?






4. What is combination TMP- SMZ used to treat?






5. What is the mechanism of action of Misoprostol?






6. What is the clinical utility of clonidine?






7. How does resistance to Vancomycin occur?






8. What are two indirect acting adrenergic agonists?






9. Foscarnet does not require activation by a...






10. What type of patient should not take Misoprostol and why?






11. List the mechanism - clinical use - & toxicity of Cisplatin.






12. Explain potency in relation to full and partial agonists(2).






13. MOA: Block peptidoglycan synthesis






14. For Warfarin What is the Onset of action






15. What are four clinical activities of Aspirin?






16. Why does NE result in bradycardia?






17. List the specific antidote for this toxin: TPA & Streptokinase






18. How is Ganciclovir activated?






19. What is the clinical use for Sildenafil (Viagra)?






20. How does NE modulate its own release? What other neurotransmitter has this same effect?






21. How can the toxic effects of TMP be ameliorated?






22. What is the clinical use for Heparin?






23. How do Sulfonamides act on bacteria?






24. What are common toxicities associated with Macrolides? (4)






25. Why is Cilastatin administered with Imipenem?






26. For Heparin What is the Duration of action






27. Decrease Digitoxin dose in renal failure?






28. List the specific antidote for this toxin: Methemoglobin






29. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






30. Is resistant to penicillinase?






31. What is Nifurtimox administered for?

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32. What are Aminoglycosides synergistic with?






33. What is the mechanism of action of Aspirin?






34. Name common Polymyxins






35. What is the clinical use for Sucralfate?






36. What is Niclosamide used for?






37. What is the chemical name for Ganciclovir?






38. Name three calcium channel blockers?






39. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






40. What is the MOA for Methicillin - Nafcillin - and Dicloxacillin?






41. Adverse effects of Hydralazine?






42. What antimuscarinic agent is used in asthma and COPD?






43. List the specific antidote for this toxin: Arsenic (all heavy metals)






44. Digoxin v. Digitoxin: protein binding?






45. Decrease Digoxin dose in renal failure?






46. What is the mechanism of Leuprolide?






47. ACE inhibitors - toxicity?






48. What is the MOA for Trimethoprim (TMP)?






49. What side effect of using atropine to induce pupillary dilation would you expect?






50. Which RT inhibitors cause a Rash?