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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What populations are Floroquinolones contraindicated in? Why?






2. What class of drug is echothiophate? What is its indication?






3. Antiarrhythmic class IC- effects?






4. What is the definition of zero - order kinetics? Example?






5. How does a noncompetitive antagonist effect an agonist?






6. Adverse effects of Reserpine?






7. What is the mechanism of action of Allopurinol used to treat chronic gout?






8. What is the mechanism of action of Misoprostol?






9. Which antimicrobial classes inhibit protein synthesis at the 30S subunit? (2)






10. Furosemide increases the excretion of What ion?






11. What is the mechanism of action of NSAIDs other than Aspirin?






12. What are common side effects of Amphotericin B?






13. Name three ACE inhibitors?






14. What is Imipenem always administered with?






15. How does a competitive antagonist effect an agonist?






16. What antimuscarinic agent is used in asthma and COPD?






17. What organisms does Griseofulvin target?






18. Thiazides - site of action?






19. What is the category - desired effect - and period of use of albuterol in the treatment of Asthma?






20. What do Aminoglycosides require for uptake?






21. Describe Phase I metabolism in liver(3)?






22. What is the category of drug names ending in - tidine (e.g. Cimetidine)






23. Adverse effects of Hydralazine?






24. Which drug(s) cause this reaction: P450 inhibition(6)?






25. How do you treat coma in the ER (4)?






26. Name some common Tetracyclines (4)






27. Which drug(s) cause this reaction: Thrombotic complications?






28. What is the mechanism of action of Omeprazole - Lansoprazole?






29. A 57 yo heart failure pt develops cardiac decompensation - What drug will give you adequate perfusion of his kidneys as well as tx for his Hypotension






30. Resistance mechanisms for Cephalosporins/Penicillins






31. What is the category - mechanism of action - and particular use of beclomethasone and prednisone in Asthma treatment?






32. For Heparin What is the Mechanism of action






33. What is the category of drug names ending in - ipramine (e.g. Imipramine)






34. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






35. What is the mechanism of Leuprolide?






36. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






37. Which drug(s) cause this reaction: Cutaneous flushing (4)?






38. Side effects of Isoniazid (INH)?






39. What microorganisms are Aminoglycosides ineffective against?






40. Ca2+ channel blockers - mechanism?






41. List the specific antidote for this toxin: Warfarin






42. Is resistant to penicillinase?






43. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






44. What is the MOA of Griseofulvin?






45. What is the loading dose formula?






46. Which diuretics increase urine Ca2+?






47. What type of gout is treated with Probenacid?






48. What is the clinical use for Ampicillin and Amoxicillin?






49. Mannitol - site of action?






50. Why would dopamine be useful in treating shock?