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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do Sulfonamides act on bacteria?






2. What organisms does Griseofulvin target?






3. MOA: Disrupt bacterial/fungal cell membranes






4. List the specific antidote for this toxin: Methanol & Ethylene glycol






5. Mg+- clinical use?






6. In coma situations you rule out What (7)?

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7. What is the MOA for Clindamycin?






8. How is Acyclovir used clinically?






9. For Heparin What is the Mechanism of action






10. For Warfarin What is the Route of administration






11. Verapamil has similar action to?






12. What parasitic condition is treated with Ivermectin?

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13. Which cancer drugs work at the level of proteins(2)?






14. Antimicrobial prophylaxis for Meningococcal infection






15. What are three toxicities of Leuprolied?






16. MOA: Block protein synthesis at 50s subunit






17. Toxic effects of TMP include?






18. How is Ganciclovir used clinically?






19. List the specific antidote for this toxin: Heparin






20. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






21. Explain differences between full and partial agonists(2).






22. Name some common Sulfonamides (4)






23. Name some common Tetracyclines (4)






24. What is a mnemonic to remember Amantadine's function?






25. As an Anes you want to use a depolarizing neuromuscular blocking drug on your pt - What do you use






26. What is the effect of guanethidine on adrenergic NE release?






27. What enzyme does Zileuton inhibit?






28. What are common serious side effects of Aminoglycosides and What are these associated with?






29. What are Amantadine - associated side effects?






30. How is Trimethoprim used clinically?






31. What is the category of drug names ending in - operidol (e.g. Haloperidol)






32. How are Interferons (INF) used clinically?

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33. What is the category of drug names ending in - olol (e.g. Propranolol)






34. How is Ganciclovir activated?






35. Which drug(s) cause this reaction: Adrenocortical Insufficiency






36. What is the mechanism of action of Mifepristone (RU486)?






37. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






38. Ethacrynic Acid - mechanism?






39. What are three possible complications of Heparin therapy?






40. Quinidine - toxicity?






41. What is the mechanism of action of Ticlopidine - Clopidogrel






42. Steady state concentration is reached in __ number of half - lifes






43. When is Rifampin not used in combination with other drugs?






44. Which drug(s) cause this reaction: Hepatitis?






45. Ryanodine - site of action?






46. What microorganisms is Aztreonam not effective against?






47. Acetaldehyde is metabolized by Acetaldehyde dehydrogenase - Which drug inhibs this enzyme?






48. What is the receptor affinity and clinical use of isoproterenol?






49. Which drug(s) cause this reaction: Stevens - Johnson syn. (3)?






50. What are toxic side effects for Metronidazole?