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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Digoxin v. Digitoxin: bioavailability?






2. Which antimuscarinic agents are used in producing mydriasis and cycloplegia?






3. What enzyme is responsible for the degredation of Ach






4. MOA: Block mRNA synthesis






5. How does Ganciclovir's toxicity relate to that of Acyclovir?






6. MOA for Penicillin (3 answers)?






7. Hydralazine - class and mechanism?






8. What are four H2 Blockers?






9. What physiological effects was the Anes using Atropine to tx






10. Antiarrhythmic class II- mechanism?






11. Which diuretics decrease urine Ca2+?






12. What is treated with Chloroquine - Quinine - Mefloquine?






13. Can Warfarin be used during pregnancy?






14. How is Ganciclovir used clinically?






15. List the specific antidote for this toxin: Anticholinesterases (organophosphate.)






16. What is the MOA for Metronidazole?






17. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






18. Ca2+ channel blockers - site of action?






19. Name the steps in drug approval(4)?






20. Name two classes of drugs for HIV therapy






21. Which Aminoglycoside is used for Bowel Surgery ?






22. What is the category and mechanism of action of Zafirlukast in Asthma treatment?






23. Are penicillinase resistant






24. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






25. Which drug(s) cause this reaction: Gynecomastia (6)?






26. What is the chemical name for Ganciclovir?






27. Why are the Sulfonylureas inactive in IDDM (type -1)?






28. List the mechanism - clinical use - & toxicity of Busulfan.






29. What is the mechanism of Tacrolimus (FK506)?






30. In What population does Gray Baby Syndrome occur? Why?






31. List the specific antidote for this toxin: Cyanide






32. ADH antagonists - site of action?






33. Furosemide - class and mechanism?






34. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






35. Toxic effects of TMP include?






36. How would hemicholinium treatment affect cholinergic neurons?






37. What is the receptor affinity and clinical use of isoproterenol?






38. Resistance mechanisms for Sulfonamides






39. Which antimicrobial classes inhibit protein synthesis at the 30S subunit? (2)






40. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






41. What is a mnemonic to remember Amantadine's function?






42. Ethacrynic Acid - toxicity?






43. Why is reserpine effective in treating HTN?






44. What is combination TMP- SMZ used to treat?






45. Furosemide - clinical use?






46. What are Fluoroquinolones indicated for? (3)






47. How would you reverse the effect of a neuromuscular blocking agent?






48. Preferential action of the Ca2+ channel blockers at vascular smooth muscle?






49. Name four HMG- CoA reductase inhibitors.






50. What are three clinical uses of the NSAIDs?