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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name the common Aminoglycosides (5)






2. Amprotericin B ___________ the BBB






3. Which RT inhibitors cause a Rash?






4. What is the mecanism of action of Sucralfate?






5. What cholinergic inhibitor acts by directly inhibiting Ach release at the presynaptic terminal






6. What is an occasional side effect of Aztreonam?






7. List the mechanism - clinical use - & toxicity of Nitrosureas.






8. Antiarrhythmic class II- mechanism?






9. How is Griseofulvin used clinically?






10. What class of drug is echothiophate? What is its indication?






11. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?






12. Antiarrhythmic class IV- primary site of action?






13. Aztreonam is not ________ with penicillins






14. What are common serious side effects of Aminoglycosides and What are these associated with?






15. What is used to reverse the action of Heparin?






16. List the specific antidote for this toxin: Cyanide






17. For Heparin What is the Ability to inhibit coagulation in vitro






18. Name four HMG- CoA reductase inhibitors.






19. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






20. Mannitol - mechanism?






21. MOA for Penicillin (3 answers)?






22. Which diuretics cause acidosis?






23. How does a noncompetitive antagonist effect an agonist?






24. For Warfarin What is the Treatment for overdose






25. What is Imipenem always administered with?






26. What is Niclosamide used for?






27. What is the MOA of the RT Inhibitors?






28. What is Metronidazole used for clinically?






29. If a patient is given hexamethonium - What would happen to his/her heart rate?






30. What is the MOA for the Aminoglycosides?






31. Antimicrobial prophylaxis for a history of recurrent UTIs






32. What is the MOA for Nystatin?






33. Which RT inhibitor causes Megaloblastic Anemia?






34. What is the mechanism of action of Allopurinol used to treat chronic gout?






35. Which diuretics increase urine NaCl?






36. List the specific antidote for this toxin: Anticholinesterases (organophosphate.)






37. Explain differences between full and partial agonists(2).






38. What is the MOA for Ampicillin and Amoxicillin?






39. Acetazolamide - mechanism?






40. What is Nifurtimox administered for?

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41. Why is pyridostigmine effective in the treatment of myasthenia gravis?






42. What are four advantages of newer low - molecular - weight heparins (Enoxaparin)?






43. What is the category - method of use - and adverse effects of Salmeterol in Asthma treatment?






44. What are common toxicities related to Vancomycin therapy?

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45. What is the MOA of Ribavirin?






46. What is the mecanism of action - effective period - and ineffective period of use for Cromolyn in treating Asthma?






47. Furosemide - toxicity? (OH DANG)






48. Which drug(s) cause this reaction: Anaphylaxis?






49. Ca2+ sensitizers'- site of action?






50. Would blockade of muscarininc receptors in the bladder be useful in treating urinary retention?