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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






2. A 57 yo heart failure pt develops cardiac decompensation - What drug will give you adequate perfusion of his kidneys as well as tx for his Hypotension






3. Which H2 Blocker has the most toxic effects and What are they?






4. What is the category of drug names ending in - cycline (e.g. Tetracycline)






5. How does botulinum toxin result in respiratory arrest?






6. What are the major toxic side effects of the Cephalosporins?






7. ACE inhibitors - toxicity?






8. For Warfarin What is the Lab value to monitor






9. What is the MOA of Ganciclovir?






10. Acetaminophen has What two clinical uses and lacks What one clinical use of the NSAIDs?






11. What is the MOA for Clindamycin?






12. What is used to reverse the action of Heparin?






13. What are the clinical indications for bethanechol?






14. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






15. What are the major structural differences between Penicillin and Cephalosporin?






16. Which drug(s) cause this reaction: Torsade de pointes (2)?






17. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






18. Why would dopamine be useful in treating shock?






19. Which drug(s) cause this reaction: Focal to massive hepatic necrosis (4)?






20. What is the category of drug names ending in - ipramine (e.g. Imipramine)






21. List the mechanism - clinical use - & toxicity of Busulfan.






22. Amprotericin B ___________ the BBB






23. Furosemide increases the excretion of What ion?






24. What enzyme does Zileuton inhibit?






25. Which drug(s) cause this reaction: Agranulocytosis (3)?






26. Describe Phase II metabolism in liver(3)?






27. Adverse effects of Losartan?






28. What is the mechanism of action of Allopurinol used to treat chronic gout?






29. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






30. What are the clinical uses for 2nd Generation Cephalosporins?






31. How is Griseofulvin used clinically?






32. Common side effects associated with Clindamycin include?






33. What is the MOA of Ribavirin?






34. What is the MOA for the Fluoroquinolones?






35. Digoxin v. Digitoxin: excretion?






36. List the mechanism - clinical use - & toxicity of Cisplatin.






37. What is the loading dose formula?






38. List the specific antidote for this toxin: Copper






39. How would you reverse the effect of a neuromuscular blocking agent?






40. What are three clinical uses of the NSAIDs?






41. What is the mechanism of action of Ticlopidine - Clopidogrel






42. Where does Griseofulvin deposit?






43. What is an additional side effect of Methicillin?






44. Name the common Nucleoside Reverse Transcriptase Inhibitors






45. Ca2+ channel blockers - clinical use?






46. What type of neurological blockade would hexamethonium create?






47. Which drug(s) cause this reaction: Aplastic anemia (5)?






48. What are two processes Corticosteroids inhibit leading to decreased inflammation?






49. How would you treat African Trypanosomiasis (sleeping sickness)?






50. What drug is used to diagnose myasthenia gravis?