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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which Tetracycline is used in patients with renal failure? / Why?






2. What is the mechanism of action of Misoprostol?






3. Name three calcium channel blockers?






4. Acetaminophen has What two clinical uses and lacks What one clinical use of the NSAIDs?






5. What is used to reverse the action of Heparin?






6. How is Rifampin used clinically?






7. What is the mechanism of action of the thrombolytics?






8. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






9. MOA: Block DNA topoisomerases






10. What is the MOA for Nystatin?






11. What is the mechanism of action of NSAIDs other than Aspirin?






12. Which drug(s) cause this reaction: Hot flashes?






13. Adverse effects of Prazosin?






14. What is a sign of toxicity with the use of thrombolytics?






15. Aztreonam is not ________ with penicillins






16. What cholinomimetics might your pt be taking for his glaucoma






17. K+ sparing diuretics - site of action?






18. What can result due to antacid overuse?






19. How does a noncompetitive antagonist effect an agonist?






20. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






21. Mannitol - toxicity?






22. How does resistance to Vancomycin occur?






23. What is a prerequisite for Acyclovir activation?






24. Why would you use pralidoxime after exposure to an organophosphate?






25. What is the memory key for Metronidazole's clinical uses?






26. List the specific antidote for this toxin: Acetaminophen






27. Name the common Non - Nucleoside Reverse Transcriptase Inhibitors






28. What is the clinical use for Penicillin?






29. Which diuretics decrease urine Ca2+?






30. What is Nifurtimox administered for?

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31. How can the toxic effects of TMP be ameliorated?






32. What is the memory key for the effect of magnesium hydroxide overuse?






33. How does botulinum toxin result in respiratory arrest?






34. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






35. The COX-2 inhibitors (celecoxib - rofecoxib) have similar side effects to the NSAIDs with What one exception?






36. What is the MOA of Isoniazid (INH)?






37. Mannitol - site of action?






38. Ca2+ channel blockers - site of action?






39. Furosemide - clinical use?






40. Name four HMG- CoA reductase inhibitors.






41. Hydralazine - class and mechanism?






42. What are common toxicities associated with Tetracyclines?

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43. Hydrochlorothiazide - clinical use?






44. What is the mechanism of action of Aspirin?






45. How is Amphotericin B used clinically?






46. How is Trimethoprim used clinically?






47. What are the side effects of Polymyxins?






48. Which Aminoglycoside is used for Bowel Surgery ?






49. Beta Blockers - CNS toxicity?






50. Which cancer drugs work at the level of proteins(2)?






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