Test your basic knowledge |

USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Why is carbachol and pilocarpine useful in treatment of glaucoma?






2. What is the clinical use of Tacrolimus (FK506)?






3. What is Fluconazole specifically used for?






4. What is the definition of zero - order kinetics? Example?






5. Name some common Sulfonamides (4)






6. What is the category of drug names ending in - pril (e.g. Captopril)






7. Describe Phase II metabolism in liver(3)?






8. Triamterene and amiloride - mechanism?






9. What is the category and mechanism of action of Zafirlukast in Asthma treatment?






10. Antiarrhythmic class IC- toxicity?






11. Antiarrhythmic class II- toxicity?






12. Antiarrhythmic class IB- toxicity?






13. What is the mechanism of action of Clomiphene?






14. Quinidine - toxicity?






15. Acetazolamide - toxicity?






16. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






17. Antimicrobial prophylaxis for Syphilis






18. Furosemide increases the excretion of What ion?






19. List the specific antidote for this toxin: Iron






20. What is the clinical utility of cocaine?






21. K+ sparing diuretics - site of action?






22. How does NE modulate its own release? What other neurotransmitter has this same effect?






23. What are four thrombolytics?






24. What Sulfonamides are used for simple UTIs?






25. What conditions would you use dantrolene?






26. Secretion of What drug is inhibited by Probenacid used to treat chronic gout?






27. Cocaine casues vasoconstriction and local anesthesia by What mechanism






28. What is the memory key for the action of Sildenafil (Viagra)?






29. What is used to reverse the action of Heparin?






30. What is the mecanism of action of Sucralfate?






31. What is the MOA for Metronidazole?






32. What are four advantages of newer low - molecular - weight heparins (Enoxaparin)?






33. What is clinical use for Carbenicillin - Piperacillin - and Ticarcillin?






34. What is the memory aid for subunit distribution of ribosomal inhibitors?


35. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






36. For Warfarin What is the Onset of action






37. Name three Antiarrhythmic drugs in class IC.






38. Are not penicillinase resistant






39. Which cancer drugs inhibit nucleotide synthesis(3)?






40. Guanethidine enhances the release of Norepi?






41. What antimuscarinic agent is used in asthma and COPD?






42. What are two clinical uses of Azathioprine?






43. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






44. What is the clinical use of Mifepristone (RU486)?






45. What is the MOA of Griseofulvin?






46. Ibutilide - toxicity?






47. What is Metronidazole used for clinically?






48. What should not be taken with Tetracyclines? / Why?






49. Which drug(s) cause this reaction: Hot flashes?






50. What are toxic side effects for Metronidazole?