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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the MOA for Metronidazole?






2. Describe Phase II metabolism in liver(3)?






3. What are common toxicities associated with Macrolides? (4)






4. What is the clinical use for Nystatin?






5. How does angiotensin II affect NE release?






6. What is action of insulin in the liver - in muscle - and in adipose tissue?






7. Which RT inhibitors cause Lactic Acidosis?






8. How do Sulfonamides act on bacteria?






9. ACE inhibitors - mechanism?






10. What are two conditions in Which COX-2 inhibitors might be used?






11. For Warfarin What is the Mechanism of action






12. What is the MOA for Amphotericin B?






13. What is the clinical use for Sucralfate?






14. Acetazolamide - toxicity?






15. What is the memory key involving the '4 R's of Rifampin?'






16. K+ sparing diuretics - toxicity?






17. While at a tail gait party - you bite into a sandwich that a yellow jacket is also enjoying. Knowing your allergy to this creature - What should you do?






18. What is the clinical utility of clonidine?






19. Which drug(s) cause this reaction: Hot flashes?






20. Which drug(s) cause this reaction: Agranulocytosis (3)?






21. Antiarrhythmic class IV- toxicity?






22. Ca2+ channel blockers - clinical use?






23. What is the clinical use of Mifepristone (RU486)?






24. What is the clinical use for Penicillin?






25. What is the clinical use for Heparin?






26. List the mechanism - clinical use - & toxicity of 6 MP.






27. How is Foscarnet used clinically?






28. How is Chloramphenical used clinically?






29. Adverse effects of Loop Diuretics?






30. What do Aminoglycosides require for uptake?






31. What are the clinical uses for 1st Generation Cephalosporins?






32. What is the memory key for Metronidazole's clinical uses?






33. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






34. Preferential action of the Ca2+ channel blockers at vascular smooth muscle?






35. Name five Antiarrhythmic drugs in class II?






36. What is a Ribavirin toxicity?






37. What are the products and their toxicities of the metabolism of ethanol by / alcohol dehydrogenase?






38. Which diuretics decrease urine Ca2+?






39. What are two toxicities of the Glitazones?






40. What is the mechanism of Tacrolimus (FK506)?






41. Which drug(s) cause this reaction: Atropine - like side effects?






42. Which diuretics cause acidosis?






43. Which individuals are predisposed to Sulfonamide - induced hemolysis?






44. What is the MOA for Methicillin - Nafcillin - and Dicloxacillin?






45. When is Rifampin not used in combination with other drugs?






46. Which drug(s) cause this reaction: Cinchonism (2)?






47. Why would you give a drug like pancuronium or succinylcholine?






48. What is the MOA for the Aminoglycosides?






49. How is Ganciclovir activated?






50. Adverse effects of Losartan?