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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. List the mechanism - clinical use - & toxicity of Bleomycin.






2. K+ sparing diuretics - site of action?






3. Side effects of Isoniazid (INH)?






4. What is the MOA for Nystatin?






5. What is the mechanism of Azathioprine?






6. Toxicities associated with Acyclovir?






7. How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax - P.ovale) treated?






8. What is the mechanism of action of Clomiphene?






9. What should not be taken with Tetracyclines? / Why?






10. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






11. For Warfarin What is the Route of administration






12. What is a common side effect of Colchicine used to treat acute gout - especially When given orally?






13. What are four thrombolytics?






14. What is the definition of zero - order kinetics? Example?






15. Digoxin v. Digitoxin: half life?






16. Which diuretics cause acidosis?






17. For Heparin What is the Lab value to monitor






18. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






19. List the mechanism - clinical use - & toxicity of Methotrexate.






20. What are common toxicities associated with Tetracyclines?

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21. Which drug(s) cause this reaction: Hot flashes?






22. Which diuretics cause alkalosis?






23. What is a Ribavirin toxicity?






24. Classes of antihypertensive drugs?






25. Which drug(s) cause this reaction: Pseudomembranous colitis?






26. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






27. How is Griseofulvin used clinically?






28. What are two toxicities of the Sulfonylureas?






29. Antiarrhythmic class II- mechanism?






30. Why is reserpine effective in treating HTN?






31. Adverse effects of Methyldopa?

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32. How can the t1/2 of INH be altered?






33. Common toxicities associated with Griseofulvin?






34. What are the clinical indications for bethanechol?






35. Adverse effects of Clonidine?






36. Which antimicrobials inhibit protein synthesis at the 50S subunit? (4)






37. Which drug(s) cause this reaction: Diabetes insipidus?






38. Name the common Fluoroquinolones (6)






39. What is the mechanism of action of the Sulfonylureas?






40. What are Methicillin - Nafcillin - and Dicloxacillin used for clinically?






41. What are three possible complications of Heparin therapy?






42. What is the main clinical use for the thrombolytics?






43. Sotalol - toxicity?






44. What effect would atropine have on a patient with peptic ulcer disease?






45. What is the mechanism of Leuprolide?






46. Foscarnet does not require activation by a...






47. Which RT inhibitors cause a Rash?






48. How is Ribavirin used clinically?






49. What is Niclosamide used for?






50. What are two indirect acting adrenergic agonists?