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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name the Protease Inhibitors (4)






2. What is the mechanism of action of Misoprostol?






3. Preferential action of the Ca2+ channel blockers at cardiac muscle?






4. Which RT inhibitors cause a Rash?






5. ADH antagonists - site of action?






6. Which of these three drugs will cause a reflex bradycardia in your pt (Norepi - Epi - or Isoporterenol)






7. How can Vancomycin - induced 'Red Man Syndrome' be prevented?






8. Name three Antiarrhythmic drugs in class IC.






9. Which drug(s) cause this reaction: Adrenocortical Insufficiency






10. List the mechanism - clinical use - & toxicity of Methotrexate.






11. Adverse effects of ganglionic blockers?






12. Clinical use of Isoniazid (INH)?






13. What is Fluconazole specifically used for?






14. What are common side effects of Amphotericin B?






15. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






16. What is the clinical utility of cocaine?






17. How is Trimethoprim used clinically?






18. What are the clinical uses for 2nd Generation Cephalosporins?






19. What is the lab value used to monitor the effectiveness of Warfarin therapy?






20. What are the Macrolides used for clinically?






21. What is the MOA for the Azoles?






22. Cautions When using Amiodarone?






23. What microorganisms are Aminoglycosides ineffective against?






24. Which drug(s) cause this reaction: Tubulointerstitial Nephritis (5)?






25. How is Amphotericin B administered for fungal meningitis?






26. Spironolactone - mechanism?






27. What is Clindamycin used for clinically?






28. What Sulfonamides are used for simple UTIs?






29. How do spare receptors effect the Km?






30. What type of neurological blockade would hexamethonium create?






31. Amiodarone - toxicity?






32. What are Aminoglycosides synergistic with?






33. What are the products and their toxicities of the metabolism of ethanol by / alcohol dehydrogenase?






34. What are four conditions in Which H2 Blockers are used clinically?






35. Specifically - How does Foscarnet inhibit viral DNA pol?






36. What effect would atropine have on the preganglionic sympathetic activation of sweat glands? Would this person sweat?






37. Explain pH dependent urinary drug elimination?






38. What is clinical use for Carbenicillin - Piperacillin - and Ticarcillin?






39. In coma situations you rule out What (7)?

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40. Is resistant to penicillinase?






41. For Heparin What is the Mechanism of action






42. Mannitol - clinical use?






43. Antiarrhythmic class II- toxicity?






44. Which drug(s) cause this reaction: Cough?






45. What is the MOA for Carbenicillin - Piperacillin - and Ticarcillin?






46. Ca2+ channel blockers - mechanism?






47. What is the mecanism of action of the COX-2 inhibitors (celecoxib - rofecoxib)?






48. Antiarrhythmic class IB- clinical uses?






49. Adverse effect of Nitroprusside?






50. Antiarrhythmic class IB- effects?