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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. List some specifics of lead poisoning(4)?






2. What are three types of antacids and the problems that can result from their overuse?






3. Which drug(s) cause this reaction: Gynecomastia (6)?






4. What is the MOA for Ampicillin and Amoxicillin?






5. What is the definition of zero - order kinetics? Example?






6. What drugs target anticholinesterase






7. What is the loading dose formula?






8. Which drug(s) cause this reaction: Hot flashes?






9. Toxicities associated with Acyclovir?






10. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






11. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






12. What is the category of drug names ending in - pril (e.g. Captopril)






13. Which RT inhibitors cause Lactic Acidosis?






14. What is the lab value used to monitor the effectiveness of Warfarin therapy?






15. Which drug(s) cause this reaction: Torsade de pointes (2)?






16. What are the clinical uses for Imipenem/cilastatin?






17. What is the effect of guanethidine on adrenergic NE release?






18. What is Ketoconazole specifically used for?






19. What is a possible result of overdose of Acetaminophen?






20. What is the mechanism of action of the thrombolytics?






21. Decrease Digitoxin dose in renal failure?






22. List the specific antidote for this toxin: Methanol & Ethylene glycol






23. How is Rifampin used clinically?






24. What are four H2 Blockers?






25. Your patient wants an effective drug to treat his motion sickness - What would you prescribe






26. What should not be taken with Tetracyclines? / Why?






27. Resistance mechanisms for Aminoglycosides






28. Furosemide - clinical use?






29. What is a Ribavirin toxicity?






30. MOA: Block protein synthesis at 50s subunit






31. Quinidine - toxicity?






32. Name four HMG- CoA reductase inhibitors.






33. What is the mechanism of Leuprolide?






34. What is a common drug interaction associated with Griseofulvin?






35. What sympathomimetic would you not prescribe for hypotension in a pt with renal artery sclerosis.






36. What are common side effects of Protease Inhibitors?






37. Amiodarone - toxicity?






38. MOA: Disrupt fungal cell membranes






39. What drug is given for Pneumocystis carinii prophylaxis?






40. Which drug(s) cause this reaction: Tendonitis and rupture?






41. Which of these three drugs will cause a reflex bradycardia in your pt (Norepi - Epi - or Isoporterenol)






42. What is the MOA for Rifampin?






43. What is the category and mechanism of action of Zileuton in Asthma treatment?






44. Amprotericin B ___________ the BBB






45. What is the effect of norepinephrine on bp and pulse pressure?






46. Which diuretics increase urine K+?






47. Decrease Digoxin dose in renal failure?






48. Resistance mechanisms for Macrolides

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49. How is Chloramphenical used clinically?






50. What is the category and mechanism of action of Zafirlukast in Asthma treatment?