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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Ethacrynic Acid - clinical use?






2. What are the products and their toxicities of the metabolism of ethanol by / alcohol dehydrogenase?






3. List the mechanism - clinical use - & toxicity of Bleomycin.






4. What is the mechanism of action of Acetaminophen?






5. Name two organisms Vancomycin is commonly used for?






6. What is the chemical name for Ganciclovir?






7. What is the mechanism of action of Colchicine used to treat acute gout?






8. What are the clinical uses for Aztreonam?






9. What is the category of drug names ending in - caine (e.g. Lidocaine)






10. What are two clinical uses of Azathioprine?






11. How is Amphotericin B administered for fungal meningitis?






12. What is the MOA of Imipenem?






13. For Heparin What is the Lab value to monitor






14. Bretyllium - toxicity?






15. Does Heparin have a long - medium - or short half life?






16. What are the products and their toxicities of the metabolism of Methanol by / alcohol dehydrogenase?






17. Side effects of Isoniazid (INH)?






18. What process does Zafirlukast interfere with?






19. Foscarnet toxicity?






20. Ryanodine - site of action?






21. Adverse effects of beta - blockers?






22. Hydralazine - clinical use?






23. The MOA for Chloramphenicol is?






24. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






25. What is the mechanism of action and clinical use of the antiandrogen Flutamide?






26. For Warfarin What is the Route of administration






27. List the mechanism - clinical use - & toxicity of Methotrexate.






28. For Warfarin What is the Site of action






29. Why would you use pralidoxime after exposure to an organophosphate?






30. What is a common side effect of Colchicine used to treat acute gout - especially When given orally?






31. What is a mnemonic to remember Amantadine's function?






32. Why does atropine dilate the pupil?






33. List the mechanism - clinical use - & toxicity of Doxorubicin.

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34. Adverse effects of ganglionic blockers?






35. What are common toxic side effects of Sulfonamides? (5)






36. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






37. Which diuretics increase urine NaCl?






38. List the specific antidote for this toxin: Copper






39. For Heparin What is the Mechanism of action






40. Resistance mechanisms for Tetracycline






41. ACE inhibitors - clinical use?






42. How does botulinum toxin result in respiratory arrest?






43. What is the effect of guanethidine on adrenergic NE release?






44. Which drug(s) cause this reaction: Hot flashes?






45. Toxicities associated with Acyclovir?






46. Verapamil has similar action to?






47. Which drug(s) cause this reaction: Thrombotic complications?






48. Are penicillinase resistant






49. What is the possible mechanism and effect of Metformin in treating diabetes?






50. Why does NE result in bradycardia?






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