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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the MOA of Foscarnet?






2. What is the category of drug names ending in - tidine (e.g. Cimetidine)






3. What is the mechanism of action of Misoprostol?






4. What is a possible toxicity of Ticlopidine - Clopidogrel usage?






5. Which drug(s) cause this reaction: Neuro and Nephrotoxic?






6. What is the effect of norepinephrine on bp and pulse pressure?






7. How is Vancomycin used clinically?






8. Where does Griseofulvin deposit?






9. What are three clinical uses of the NSAIDs?






10. What are common serious side effects of Aminoglycosides and What are these associated with?






11. Toxic side effects of the Azoles?






12. How do we stop angina?






13. Adverse effects of Hydrochlorothiazide?






14. Name three K+ sparing diuretics?






15. Guanethidine enhances the release of Norepi?






16. What are the major toxic side effects of the Cephalosporins?






17. Why would you give a drug like pancuronium or succinylcholine?






18. Furosemide - clinical use?






19. Adverse effects of Reserpine?






20. Ca2+ sensitizers'- site of action?






21. MOA for Penicillin (3 answers)?






22. What are Fluoroquinolones indicated for? (3)






23. How do the Protease Inhibitors work?






24. Why would dopamine be useful in treating shock?






25. What is the specific clinical use of Indomethacin in neonates?






26. What are three toxicities of Propylthiouracil?






27. List the specific antidote for this toxin: TPA & Streptokinase






28. What are two types of drugs that interfere with the action of Sucralfate and why?






29. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






30. What is the MOA of Aztreonam?






31. For Warfarin What is the Site of action






32. MOA: Block DNA topoisomerases






33. Ca2+ channel blockers - clinical use?






34. Adverse effects of Clonidine?






35. How does a noncompetitive antagonist effect an agonist?






36. Why would a patient with cog - wheel rigidity and a shuffling gait be given benztropine?






37. What are two toxicities associated with Cyclosporine?






38. Hydrochlorothiazide - mechanism?






39. What is Metronidazole combined with for 'triple therapy'? Against What organism?






40. What is the mechanism of action of the Alpha - glucosidase inhibitors?






41. What is the category of drug names ending in - barbital (e.g. Phenobarbital)






42. For Warfarin What is the Duration of action






43. What type of neurological blockade would hexamethonium create?






44. Ca2+ channel blockers - toxicity?






45. Norepi feedbacks and inhibits the presynaptic receptor by What mechanism






46. What is the mechanism of action of the Sulfonylureas?






47. Explain pH dependent urinary drug elimination?






48. What is action of insulin in the liver - in muscle - and in adipose tissue?






49. What microorganisms are clinical indications for Tetracycline therapy?

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50. How is Chloramphenical used clinically?