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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Why are the Sulfonylureas inactive in IDDM (type -1)?






2. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






3. What should not be taken with Tetracyclines? / Why?






4. Triamterene and amiloride - mechanism?






5. What is the mechanism of action of Acetaminophen?






6. What are four conditions in Which H2 Blockers are used clinically?






7. Why does atropine dilate the pupil?






8. If a patient is given hexamethonium - What would happen to his/her heart rate?






9. What do Aminoglycosides require for uptake?






10. What are two Alpha - glucosidase inhibitors?






11. ___________ are Teratogenic






12. What is the category of drug names ending in - barbital (e.g. Phenobarbital)






13. What is the MOA of the RT Inhibitors?






14. How is Vancomycin used clinically?






15. List the mechanism - clinical use - & toxicity of Cyclophosphamide.






16. What is the category of drug names ending in - caine (e.g. Lidocaine)






17. Ibutilide - toxicity?






18. Name four Antiarrhythmic drugs in class IA.






19. What are two Glitazones?






20. A 57 yo heart failure pt develops cardiac decompensation - What drug will give you adequate perfusion of his kidneys as well as tx for his Hypotension






21. List the specific antidote for this toxin: Acetaminophen






22. Antiarrhythmic class IB- effects?






23. How do we stop angina?






24. What is the possible mechanism and effect of Metformin in treating diabetes?






25. Which drug(s) cause this reaction: Torsade de pointes (2)?






26. Mannitol - clinical use?






27. What is the clincial use for Misoprostol?






28. What is the memory key for the effect of magnesium hydroxide overuse?






29. MOA: Block protein synthesis at 50s subunit






30. Common toxicities associated with Fluoroquinolones?






31. What is the lab value used to monitor the effectiveness of Heparin therapy?






32. List the specific antidote for this toxin: Carbon monoxide






33. What is a common side effect of Colchicine used to treat acute gout - especially When given orally?






34. What are the Anti - TB drugs?






35. Adverse effects of Clonidine?






36. What is the mechanism of action of Clomiphene?






37. What is the memory key for Isoniazid (INH) toxicity?






38. What is the mechanism of Tacrolimus (FK506)?






39. How do the Protease Inhibitors work?






40. What are two toxicities of the Glitazones?






41. What are three types of antacids and the problems that can result from their overuse?






42. Resistance mechanisms for Sulfonamides






43. List the specific antidote for this toxin: Tricyclic antidepressants






44. Name the common Fluoroquinolones (6)






45. Which H2 Blocker has the most toxic effects and What are they?






46. Hydralazine - toxicity?






47. What is the category of drug names ending in - cillin (e.g. Methicillin)






48. Which of epi - norepi - or isoproterenol results in bradycardia?






49. ADH antagonists - site of action?






50. How is Griseofulvin used clinically?







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