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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What enzymes are inhibited by NSAIDs - acetaminophen and COX II inhibitors?






2. Name the common Fluoroquinolones (6)






3. What are the nondepolarizing neuromuscular blocking drugs?






4. Ethacrynic Acid - clinical use?






5. What enzyme does Zileuton inhibit?






6. What are four clinical uses of glucocorticoids?

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7. Antiarrhythmic class IV- effects?






8. What is the MOA for Vancomycin?






9. What is the only depolarizing neuromuscular blocking agent?






10. How do spare receptors effect the Km?






11. What are the products and their toxicities of the metabolism of ethanol by / alcohol dehydrogenase?






12. What is the clinical use for Nystatin?






13. Beta Blockers - BP?






14. Common toxicities associated with Griseofulvin?






15. What effect would atropine have on the preganglionic sympathetic activation of sweat glands? Would this person sweat?






16. MOA: Block peptidoglycan synthesis






17. List the specific antidote for this toxin: Opioids






18. Which drug(s) cause this reaction: Diabetes insipidus?






19. What is the category of drug names ending in - oxin (e.g. Digoxin)






20. What are Polymyxins used for?






21. Which drug(s) cause this reaction: Disulfram - like reaction (4) ?






22. What is the MOA of Griseofulvin?






23. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






24. In coma situations you rule out What (7)?

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25. What are the Anti - TB drugs?






26. Ca2+ channel blockers - site of action?






27. MOA: Block protein synthesis at 30s subunit






28. Explain potency in relation to full and partial agonists(2).






29. What is the mechanism of action of Probenacid used to treat chronic gout?






30. What is an occasional side effect of Aztreonam?






31. How is Leishmaniasis treated?






32. Why would you use pralidoxime after exposure to an organophosphate?






33. Antiarrhythmic class IB- toxicity?






34. Which drug(s) cause this reaction: Neuro and Nephrotoxic?






35. What is the specific clinical use of Indomethacin in neonates?






36. Which cancer drugs work at the level of mRNA(2)?






37. Resistance mechanisms for Chloramphenicol






38. What is the MOA for Amphotericin B?






39. Acetazolamide causes?

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40. What is the MOA for Acyclovir?






41. Explain differences between full and partial agonists(2).






42. What is the category of drug names ending in - cillin (e.g. Methicillin)






43. What is the mechanism of action of Warfarin (Coumadin)?






44. What are the side effects of Rifampin?






45. Does Ampicillin or Amoxicillin have a greater oral bioavailability?






46. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






47. A fellow passenger on a Carnival cruise ship looks pale and diaphoretic - What antimuscarinic agent would you give them?






48. What is the clinical use for Warfarin?






49. What are Amantadine - associated side effects?






50. Which drug(s) cause this reaction: Drug induced Parkinson's (4) ?