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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. MOA: Block DNA topoisomerases






2. How is Ganciclovir used clinically?






3. What is Metronidazole combined with for 'triple therapy'? Against What organism?






4. Which RT inhibitor causes Megaloblastic Anemia?






5. Oral Penicillin






6. How is Amphotericin B used clinically?






7. How does NE modulate its own release? What other neurotransmitter has this same effect?






8. What is the mechanism of action of Ticlopidine - Clopidogrel






9. How is Amphotericin B administered for fungal meningitis?






10. What are three toxicities of Leuprolied?






11. What antimuscarinic drug is useful for the tx of asthma






12. How can the t1/2 of INH be altered?






13. What are three possible toxicities of NSAID usage?






14. What is the mechanism of action of Probenacid used to treat chronic gout?






15. What are the clinical indications for Azole therapy?






16. What is the MOA of Ganciclovir?






17. What organisms does Griseofulvin target?






18. What is the definition of zero - order kinetics? Example?






19. What are Aminoglycosides used for clinically?






20. Resistance mechanisms for Macrolides

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21. Side effects of Isoniazid (INH)?






22. Which drug(s) cause this reaction: Cinchonism (2)?






23. What are three toxicities of Propylthiouracil?






24. Antiarrhythmic class II- effects?






25. What are five disadvantages of Oral Contraceptives (synthetic progestins - estrogen)?






26. What is the category of drug names ending in - barbital (e.g. Phenobarbital)






27. What is the memory key to remember Which pathway (extrinsic vs. intrinsic) and Which lab value Warfarin affects?






28. Bretyllium - toxicity?






29. Which individuals are predisposed to Sulfonamide - induced hemolysis?






30. What is the lab value used to monitor the effectiveness of Warfarin therapy?






31. What is the memory aid for subunit distribution of ribosomal inhibitors?

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32. Name the Protease Inhibitors (4)






33. What is a common side effect of Misoprostol?






34. For Warfarin What is the Treatment for overdose






35. What are the clinical uses for 1st Generation Cephalosporins?






36. Why is reserpine effective in treating HTN?






37. What conditions would you use dantrolene?






38. What are two conditions in Which COX-2 inhibitors might be used?






39. Name two LPL stimulators.






40. Ca2+ channel blockers - toxicity?






41. What is the category of drug names ending in - triptyline (e.g. Amitriptyline)






42. What are toxic side effects for Metronidazole?






43. What are the clinical uses for Imipenem/cilastatin?






44. What is the mechanism of action of Heparin?






45. Which drug(s) cause this reaction: Adrenocortical Insufficiency






46. Name the steps in drug approval(4)?






47. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






48. What is the mechanism of action of Acetaminophen?






49. Name three Antiarrhythmic drugs in class IC.






50. Ca2+ channel blockers - mechanism?