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USMLE Step 1 Pharmacology

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. List the mechanism - clinical use - & toxicity of Etoposide.






2. What is Imipenem always administered with?






3. What two vasodilators require simultaneous treatment with beta blockers to prevent reflex tachycardia and diuretics to prevent salt retention?






4. What is the clinical use of Tacrolimus (FK506)?






5. Name three Antiarrhythmic drugs in class IC.






6. Hydrochlorothiazide - clinical use?






7. What is the category - desired effect - and possible mechanism of Theophylline in treating Asthma?






8. Adverse effects of Prazosin?






9. What is the category of drug names ending in - zosin (e.g. Prazosin)






10. What is the MOA for Vancomycin?






11. What are three unwanted effects of Mifepristone?






12. These drugs acts indirectly by releasing strored catecholamines in the presynaptic terminal






13. What are two conditions in Which COX-2 inhibitors might be used?






14. What is the MOA for Rifampin?






15. For Warfarin What is the Duration of action






16. What are common toxicities associated with Macrolides? (4)






17. What type of neurological blockade would hexamethonium create?






18. What is the MOA for Nystatin?






19. Clonidine is the preferred sym pathomimetic tx of HTN in pts with renal disease - why??






20. Name four Antiarrhythmic drugs in class IA.






21. What is the MOA for the Aminoglycosides?






22. What is the mechanism of action of NSAIDs other than Aspirin?






23. What cholinomimetics might your pt be taking for his glaucoma






24. Name the common Non - Nucleoside Reverse Transcriptase Inhibitors






25. What are common side effects of Amphotericin B?






26. What populations are Floroquinolones contraindicated in? Why?






27. What is an additional side effect of Methicillin?






28. What is the category of drug names ending in - barbital (e.g. Phenobarbital)






29. Beta Blockers - CV toxicity?






30. What is a mnemonic to remember Amantadine's function?






31. What are two mechanisms of action of Propythiouracil?






32. Describe first - order kinetics?






33. What enzyme is responsible for the degredation of Ach






34. What is the category of drug names ending in - caine (e.g. Lidocaine)






35. List the specific antidote for this toxin: Opioids






36. Ethacrynic Acid - clinical use?






37. Foscarnet does not require activation by a...






38. What enzyme is responsible for the production of Ach from Acetyl CoA and Choline






39. What is the memory key for the effect of aluminum hydroxide overuse?






40. Which cancer drugs inhibit nucleotide synthesis(3)?






41. Does Heparin have a long - medium - or short half life?






42. What is the MOA for the Azoles?






43. MOA: Bactericidal antibiotics






44. What are Amantadine - associated side effects?






45. Ibutilide - toxicity?






46. What physiological effects was the Anes using Atropine to tx






47. What is the MOA for Acyclovir?






48. Will Hemicholinum affect the release of stored Ach during Cholinergic Stimulation






49. What is the category of drug names ending in - ane (e.g. Halothane)






50. List the mechanism - clinical use - & toxicity of Vincristine.

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