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USMLE Step 1 Pharmacology

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  • Answer 50 questions in 15 minutes.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are five toxicities associated with Tacrolimus (FK506)?






2. What is combined with Ampicillin - Amoxicillin - Carbenicillin - Piperacillin - and Ticarcillin to enhance their spectrum?






3. Which drug(s) cause this reaction: Atropine - like side effects?






4. Name two LPL stimulators.






5. What is a possible result of overdose of Acetaminophen?






6. List the specific antidote for this toxin: Salicylates






7. Acetazolamide - clinical uses?






8. A 12yo patient was treated for a reaction to a bee sting - What drug provides the best coverage of sympathomimetic receptors?






9. Which of the following would atropine administration cause? Hypothermia - bradycardia - excess salivation - dry flushed skin - or diarrhea






10. What is the MOA of Foscarnet?






11. Clinical use of Isoniazid (INH)?






12. In What population does Gray Baby Syndrome occur? Why?






13. List the specific antidote for this toxin: Cyanide






14. What are the nondepolarizing neuromuscular blocking drugs?






15. Name some common Sulfonamides (4)






16. What are common side effects of Protease Inhibitors?






17. What enzyme is responsible for the breakdown of ACh in the synaptic cleft?






18. Which drug(s) cause this reaction: Stevens - Johnson syn. (3)?






19. Which drug(s) cause this reaction: Pulmonary fibrosis(3)?






20. What are four H2 Blockers?






21. For Heparin What is the Treatment for overdose






22. What is the mechanism of Tacrolimus (FK506)?






23. Aztreonam is not usually...






24. Adverse effects of Methyldopa?

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25. MOA: Block nucleotide synthesis






26. List the specific antidote for this toxin: Opioids






27. What are are the Sulfonylureas (general description) and What is their use?






28. Why does atropine dilate the pupil?






29. Mannitol - contraindications?






30. As an Anes you want to use a depolarizing neuromuscular blocking drug on your pt - What do you use






31. What is the clinical use for Sildenafil (Viagra)?






32. Guanethidine enhances the release of Norepi?






33. What should not be taken with Tetracyclines? / Why?






34. What do Aminoglycosides require for uptake?






35. MOA: Block protein synthesis at 30s subunit






36. Are not penicillinase resistant






37. Why is pyridostigmine effective in the treatment of myasthenia gravis?






38. What is the clinical use for Sucralfate?






39. What is the enzyme inhibited - the effect of this inhibition - and the clinical use of the antiandrogren Finasteride?






40. Esmolol - short or long acting?






41. Acetazolamide - mechanism?






42. K+- clinical use?






43. Nifedipine has similar action to?






44. What reversal agent could a Anes give to reverse the effects of Atropine






45. What are toxicities associated with Chloramphenicol?






46. What is used to reverse the action of Heparin?






47. What is the memory key for the effect of aluminum hydroxide overuse?






48. What are Aminoglycosides used for clinically?






49. ACE inhibitors - clinical use?






50. What is the memory key for the effect of magnesium hydroxide overuse?







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