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USMLE Step 1 Prep

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the four functions of saliva?






2. What AA is substituted for glutamic acid at position 6 on the Beta - chain in patients with sickle cell anemia?






3. What is the term for inflamed - thickened skin on the breast with dimpling associated with cancer?

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4. What happens to plasma concentration of a drug if there is a large volume of distribution?






5. The separation of 46 homologous chromosomes without splitting of the centromeres occurs During what phase of meiosis?






6. Name the pattern of genetic transmission characterized thus: both M and F are affected; M may transmit to M; each generation has at least one affected parent; and one mutant allele may produce the disease.






7. What form of hormone is described as having membrane - bound receptors that are stored in vesicles - using second messengers - and having its activity determined by free hormone levels.






8. What organism would you suspect in a patient with diarrhea after eating rice?






9. What type of pleura is adherent to the surface of the organ?






10. Name the cancer associated with the following chemical agents. (Some may have more than one answer.) x Asbestos






11. Which antihyperlipidemic agent would you not prescribe for a patient with a history of gout or PUD?






12. What are the two side effects of opioids to which the user will not develop tolerance?






13. What changes does more negative intrathoracic pressure cause to systemic venous return and to the pulmonary vessels?






14. What is the signal to open the voltage - gated transmembrane potassium channels?






15. Name the eukaryotic RNA polymerase based on the following: x Synthesizes hnRNA - mRNA - and snRNA






16. What subtype of schizophrenia is characterized by x Stuporous mute echopraxia and automatic obedience - waxy flexibility with rigidity of posture?






17. Where is renin produced?






18. What are five clinical signs of portal HTN?






19. Name the associated chromosome - Chronic lymphocytic leukemia (CLL)






20. Which laxative is used in the treatment of hepatic encephalopathy ?






21. What are the four segmented RNA viruses?






22. What disorder is associated with loss of polarity - anaplasia - pleomorphism - discohesiveness - increase in the nuclear:cytoplasmic ratio - hyperchromasia - and increase in the rate of mitosis?






23. What AD disease is associated with chromosome 4p; does not present until the person is in his or her 30s; and involves atrophy of the caudate nucleus - dilatation of the lateral and third ventricles - and signs of extrapyramidal lesions?






24. Name the area of the cerebral cortex with the function described: x Speech; critical for personality - concentration - initiating and stopping tasks (do one thing and begin a new without completion of the first) - abstract thought - and memory and hi






25. Do the following structures pick up stain from hematoxylin or eosin? - Calcium






26. What are the three effects of insulin on protein metabolism?






27. What right - to - left shunt occurs when the aorta opens into the right ventricle and the pulmonary trunk opens into the left ventricle?






28. Megaloblastic anemia and thrombocytopenia are signs of what vitamin deficiency?






29. How many ATPs are hydrolyzed every time a skeletal muscle cross - bridge completes a single cycle?






30. What CNS tumor arises from Rathke's pouch?






31. Close before the valves on the left side of the heart.






32. Name the muscle type based on these descriptions: x Involuntary contraction - uninuclear nonstriated fibers - actin and myosin not forming banding pattern; lack of T tubules - gap junctions - and calmodulin.






33. What is the only specific Ag - presenting cell?






34. Which chromosome is associated with MHC genes?






35. After fertilization - what cells of the corpus luteum x Secrete progesterone?






36. What enzyme is inhibited by disulfiram?






37. What is the DOC for trigeminal neuralgia?






38. Name the antidote - Nitrates






39. What wave is the cause of the following venous pulse deflections? - The bulging of the tricuspid valve into the right atrium






40. What type of fiber or fibers are carried in (answer motor - sensory - or both) x Spinal nerve?






41. What vitamin is a cofactor of aromatic amino acid decarboxylase and decreases the efficacy of L- dopa if used concomitantly?






42. Which hepatitis virus is in the Picornaviridae family?






43. Name the antidote - Warfarin






44. What is the term to describe the increased rate of secretion of adrenal androgens at the onset of puberty?






45. Name the ocular lesion; be specific - Left Meyer's loop lesion of the optic radiations.






46. Which acid - fast rod is an obligate intracellular parasite?






47. What embryonic structure forms the following adult structures? - Nephrons - kidney






48. What disease involves microcephaly - mental retardation - cleft lip or palate - and dextrocardia?






49. The duodenal - jejunal flexure is suspended from the posterior abdominal wall by what?






50. What small - to medium - sized vasculitis is seen in a 35-year - old man who is a heavy smoker presenting with claudication symptoms in the upper and lower extremities?