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Test your basic knowledge |
USMLE Step 1 Prep
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What bedside test is used to differentiate a dorsal column lesion from a lesion in the vermis of the cerebral cortex?
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2. What Enterobacteriaceae are prone to produce osteomyelitis in sickle cell patients?
Salmonella
Rheumatoid arthritis and type 1 diabetes (with HLA- DR3)
Ritodrine and terbutaline
LTC4 - LTD4 - and LTE4
3. How many oogonia are present at birth?
None; they are not formed until a girl reaches puberty.
Short - chain fatty acids
Wilson disease
Ampulla of the fallopian tube
4. If you order a V/Q scan for suspected pulmonary emboli - is the filling defect seen on the ventilation or perfusion side?
Streptococcus viridans
C3a - C4a - C5a
Left heart failure
Ventilation of an unperfused lung segment is highly suspicious for pulmonary embolism.
5. What type of cell can never leave the lymph node?
1:1. Remember - the flow through the pulmonary circuit and the systemic circuit are equal.
Central/neurogenic diabetes insipidus; in the nephrogenic form there is sufficient ADH available - but the renal collecting ducts are impermeable to its actions.
Plasma cell
Regression
6. Where are the LMN cell bodies of the corticospinal tract?
Kayser - Fleischer rings
Shigella
In the ventral horn of the spinal cord. UMN cell bodies are in the precentral gyrus of the frontal lobe.
Cestodes
7. What is the term for a single isolated antigenic determinant?
CN V
Prinzmetal variant angina
Central sulcus (sulcus of Rolando)
Hapten (not immunogenic)
8. When does the primitive gut herniate out of the embryo? When does it go back into the embryo?
GP120
Acute cystitis
Dopamine
6 weeks 10 weeks
9. In what rare lung malignancy have 90% of patients had an occupational exposure to asbestos?
Secondary erectile disorder (Male erectile disorder is the same as impotence.)
Kinesins. Dynein generates retrograde transportation of information.
Malignant mesothelioma
Thoracic and sacral
10. What lipoprotein is formed if an IDL particle acquires cholesterol from a HDL particle?
LDL
Ventral posteromedial nucleus
Aspiration
Leydig cell tumor
11. What nephrotic syndrome has effacement of the epithelial foot processes without immune complex deposition?
Chlamydia psittaci
Minimal change disease
The optic disk is the blind spot.
Hepatitis C
12. Are the following responses associated with histamines H1 or H2 receptor activation? - Pain and pruritus
C1 through C4
Bronchial asthma (whorled mucous plugs)
H 1
Vitelline fistula
13. What cestode causes cysticercosis?
Alcoholic cirrhosis
Pubis - ilium - and ischium
Taenia solium
HBsAb IgG
14. A depressive patient who is taking paroxetine goes to the ER with pain and is given meperidine. Shortly afterward she develops diaphoresis - myoclonus - muscle rigidity - hyperthermia - and seizures. What is your diagnosis?
Serotonergic crisis may be precipitated when an SSRI is mixed with MAOIs - TCADs - dextromethorphan - and meperidine. Treat it with cyproheptadine.
Alcohol consumption
Valproic acid
Conjugated (direct) hyperbilirubinemia - a transport defect
15. What is the most common one? - Malignant carcinoma of the ovaries
14 days in most women (Remember - the luteal phase is always constant.)
Glycogen phosphorylase
Cystadenocarcinoma
Plasmodium vivax
16. Name these immature defense mechanisms: x Taking others' beliefs - thoughts - and external stimuli and making them part of the self. (Hint: if it's done consciously - it is called imitation.)
Taenia saginata
Introjection (a sports fan is a good example)
Klebsiella pneumoniae
An increase in serum glucose levels
17. What congenital small bowel outpouching is a remnant of the vitelline duct?
Neuroleptic malignant syndrome is a potentially life - threatening condition Which is treated with symptomatic support - bromocriptine - and dantrolene.
Meckel diverticulum
Hypoparathyroidism
A high - resistance system is formed when resistors are added in a series.
18. What CN is associated with the x First pharyngeal arch?
K1 capsule
Testicular feminization syndrome (Dude looks like a lady!)
CN V
Neuroleptic malignant syndrome is a potentially life - threatening condition Which is treated with symptomatic support - bromocriptine - and dantrolene.
19. What breast pathology involves malignant cells with halos invading the epidermis of the skin?
Antimicrobial agents
Chromosome 19
Hemolytic uremic syndrome
Paget disease of the breast
20. A 20-year - old woman goes to the ER with ptosis - diplopia - weakness in her jaw muscles when chewing - and muscle weakness with repeated use. What is your diagnosis?
Decrease in surface area and increase in membrane thickness (Palv O2 > PaO2)
Glomerular capillary pressure (increased glomerular capillary pressure - increased GFR and vice versa)
Ascaris lumbricoides
Myasthenia gravis
21. What stage of male development is characterized by the following LH and testosterone levels? - LH secretion drives testosterone production - with both levels paralleling each other.
igantism
Adulthood
Osteoclasts
IgA nephropathy (Berger disease)
22. How is velocity related to the total cross - sectional area of a blood vessel?
1. Competition for carrier with similar chemical substances 2. Chemical specificity needed for transportation 3. Zero - order saturation kinetics (Transportation is maximal when all transporters are saturated.) 4. Rate of transportation faster than i
One day after the LH surge and 2 days after the estrogen peak.
Velocity is inversely related to cross - sectional area.
1. Fat 2. Forty 3. Female 4. Familial 5. Fertile
23. Which way does the Hgb - O2 dissociation curve shift in patients with CO poisoning?
The pathologic problem with CO poisoning is that CO has 240 times as much affinity for Hgb molecule as does O2 - reducing the carrying capacity and shifting the curve to the left - making it difficult to remove the CO molecule from Hgb.
Merkel cells (Merkel's tactile cells)
Selegiline
Constriction of efferent arteriole
24. What is the pentad of TTP?
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25. What drug is used to differentiate a cholinergic crisis from myasthenia gravis?
Edrophonium
Hemiazygous vein
10% are bilateral - 10% malignant - and 10% familial - 10% in children - and 10% outside the adrenal gland
Lateral cricoarytenoid muscles
26. Name the most common cause - Insomnia
Glucokinase
Kl
Depression
HHV 6
27. Name the following descriptions associated with bacterial endocarditis: x Retinal emboli
The secretory phase is progesterone - dependent and 14 days long - whereas the length of the proliferative phase varies
Plasmodium malariae; the others are tertian.
Roth spots
Enterokinase
28. What cells of the adrenal gland are neural crest derivatives?
Pneumothorax
Chondroitin sulfate and keratan sulfate
Chromaffin cells (adrenal medulla)
REM sleep occurs more often in the second half of sleep. The amount of REM sleep increases as the night goes on.
29. What hormone level increases in the first 3 hours of sleep?
Prolactin
Fungi
Cushing's disease (pituitary) has elevated ACTH and cortisol suppression with dexamethasone - whereas Cushing's syndrome (adrenal adenoma) has decreased ACTH and no cortisol suppression with dexamethasone.
Osteogenesis imperfecta
30. What antiviral agents inhibit neuraminidases of influenza A and B?
ACh
Paranoid
Zanamivir and oseltamivir
Respiratory alkalosis (summary: low CO2 - low H+ - slightly low HCO3-)
31. T cells can recognize - bind - and internalize...
Misoprostol
Pedophilia
unprocessed Ags
S phase
32. How many days before the first day of menstrual bleeding is ovulation?
Ascorbic acid (vitamin C) deficiency (These are the signs of scurvy.)
14 days in most women (Remember - the luteal phase is always constant.)
In men it is prostate cancer - and in women it is breast cancer.
Temporal lobes
33. What papillae are touch receptors on the tongue and send their sensations via CN V3 (mandibular division)?
Eosinophil
Filiform papillae
Lead
Minocycline
34. The 'tea - and - toast' diet is classically associated with what cause of megaloblastic anemia?
CN XII
Dihydrofolate reductase
Gout
Folate deficiency (very common in the elderly)
35. The clearance of what substance is the gold standard of renal plasma flow?
Tetracyclines
The superior mesenteric vein and the splenic vein (after it receives the inferior mesenteric vein) join to form the portal vein.
IDL
Para - aminohippurate (PAH)
36. By What age should children be able to draw the following figures? - Cross
4 years old
Lethal dose for 50% of drug takers (median lethal dose)
Fluconazole
Aminoacyl - tRNA synthetase - which uses 2 ATPs for this reaction.
37. What preganglionic sympathetic fibers are responsible for innervating the smooth muscle and glands of the pelvis and the hindgut?
Lumbar splanchnics
Dihydrofolate reductase
Thiamine
Stable
38. Do the following structures pick up stain from hematoxylin or eosin? - Cytoplasm
Osteoclasts
Proline and lysine
Eosin
Hepatitis E (enteric)
39. What test uses p24 protein when diagnosing HIV?
Temporal lobes
Pulmonary shunt (i.e. - pulmonary embolism)
ELISA test
Transvestite fetishism
40. What is the costliest health care problem in the United States?
Decreases
Osteoclasts
IgG
Alcohol and its related problems cost the country approximately $100 billion a year.
41. What three AAs are used to synthesize the purine ring?
1. Glycine 2. Aspartate 3. Glutamine
Are inactivated vaccines available in the United States
Chronic end - stage renal disease
Glutamine and aspartate
42. What are the three sites where CSF can leave the ventricles and enter the subarachnoid space? (Name the lateral and the medial foramina.)
X- linked dominant
Two Lateral foramina of Luschka and 1 Medial foramen of Monroe (L for Lateral and M for Medial)
Small to medium - sized cerebral vessels
Uricosuric
43. What are the two most common viral infections in HIV?
The patient decides about the health care she does or does not get even if it harms the fetus. This also means she can refuse blood transfusions even if it harms the fetus.
Magnesium
Reticulocyte
CMV retinitis and HSV-2
44. What growth factors are chondrogenic - working on the epiphyseal end plates of bone?
Thyroid gland
The superior border of the inferior intercostal rib is your landmark for a pleural tap because along the inferior border of each rib is the neurovascular bundle - and you would risk injury if you went below the rib.
GH- producing adenoma
Somatomedins (IGF-1)
45. What is secretin's pancreatic action?
Adenosine deaminase
Ventricular fibrillation (V fib)
Secretin stimulates the pancreas to secrete a HCO3-- rich solution to neutralize the acidity of the chyme entering the duodenum.
Amiloride
46. What enzyme is deficient in the following glycogen storage disease? - McArdle's disease
>3.5 g/day of protein - along with generalized edema - hypoalbuminemia - and hyperlipidemia
Lead
Muscle glycogen phosphorylase
Burkitt lymphoma
47. What is the most common one? - Primary malignant tumor of the female genital tract in the world
Cervical neoplasia
Metastatic calcification
Basophilic stippling
Listeria
48. What type of Plasmodium affects x Only mature RBCs?
Gubernaculum
Vitamin K deficiency has normal bleeding time and increased PT - and vitamin C deficiency has increased bleeding time and normal PT.
Francisella tularensis
Plasmodium malariae
49. Name the B- cell CD marker: x Used clinically to count B cells in blood
CD19
S phase
Paracortex
Displacement
50. Name the associated chromosome - Neurofibromatosis type 2
Bioavailability
Yolk sac tumor
Hepatitis B
Chromosome 22q