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USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What is the DOC for coccidioidomycosis?
G2 phase
Fluconazole
Osteocyte
H1 histones

2. Name the cancer associated with the following tumor markers. (Some may have more than one answer.) x Calcitonin
Tryptophan
Medullary carcinoma of the thyroid
Creatinine
1. Laminin 2. Heparan sulfate (heparitin sulfate) 3. Fibronectin 4. Type IV collagen

3. Curschmann spirals
Chlortetracycline
Areas 1 - 2 - and 3
Bronchial asthma (whorled mucous plugs)
Minimal change disease

4. What Brodmann area is associated with x Broca's area?
HDL
Areas 44 and 45
Pseudomonas
Increased CO2 - H+ - temperature - and 2 - 3- BPG levels all shift the curve to the right - thereby making the O2 easier to remove (decreased affinity) from the Hgb molecule.

5. How early can a pregnancy be detected by hCG assays in the blood? In urine?
hCG can be detected in the blood by day 8 and in the urine by day 10.
Adult polycystic kidney disease
Hematogenous
1. Increased amino acid uptake by muscles 2. Decreased protein breakdown 3. Increased protein synthesis

6. Name the associated chromosomal translocation - M3 AML
Haemophilus influenzae type B
External abdominal oblique
Negative
Chromosome 15 - 17

7. What two glycolytic enzymes catalyze the substrate - level phosphorylations?
Rifampin
3- Phosphoglycerate kinase and pyruvate kinase; this produces two ATPs per enzyme (total four ATPs)
Gangrenous necrosis
Increased pulmonary arterial pressure (high perfusion) and more distensible vessels (low resistance) result in increased blood flow at the base.

8. What hormone has the following effects: chondrogenic in the epiphyseal end plates of bones; increases AA transport for protein synthesis; increases hydroxyproline (collagen); and increases chondroitin sulfate synthesis?
GH - especially IGF-1. GH also increases the incorporation of thymidine in DNA synthesis and uridine in RNA synthesis.
Poxvirus
Frotteurism
Goodpasture disease

9. In regard to motor development during infancy - choose the motor response that happens first - Release or grasp
Sulfonamides
Grasp proceeds release
One day after the LH surge and 2 days after the estrogen peak.
Choriocarcinomas and trophoblastic tumors

10. What AR disease involves a defect in AA 508 on chromosome 7 - causing a defect in Cl - transportation that leads to recurrent pulmonary infections and an increase in viscid mucoid secretions along with pancreatic insufficiencies?
Unconjugated free bilirubin
Loss of isotonic fluid (diarrhea - vomiting - hemorrhage)
Neutrophils - eosinophils - and basophils
Cystic fibrosis. (Parents are usually the first to find out because the baby tastes salty.)

11. What protein deficiency results in respiratory distress syndrome of newborns?
prior to birthThe foramen ovale closes just...
S phase
Deficiency in surfactant
Minimal change disease

12. What form of alcohol causes blindness?
Left colic - superior rectal - and sigmoidal arteries
The ECF compartment always enlarges when there is a net gain in total body water and decreases when there is a loss of total body water. Hydration status is named in terms of the ECF compartment.
Methanol (wood alcohol)
Chromosome 7

13. What nucleus supplies the preganglionic parasympathetic fibers to the ciliary ganglion?
6 ATPs (remember 2 pyruvates per glucose are produced - and 2 NADHs result from production of acetyl CoA - so 6 ATPs)
Concentration gradient
Edinger - Westphal nucleus (via CN III)
Cleft palate

14. What phase of the female reproductive cycle is 14 days long?
High volume - watery solution; sympathetic stimulation results in thick - mucoid saliva.
PRPP aminotransferase
Esophagus - SVC - vagus nerve - azygos vein - thoracic duct - thymus - and phrenic nerve
The secretory phase is progesterone - dependent and 14 days long - whereas the length of the proliferative phase varies

15. Prolactin levels can serve as a rough indicator of...
a - and Beta- chains are on most T cells.
Immature B cells
Metaphase of meiosis II (in the oocyte of the graafian follicle)
overall dopamine activity

16. Name the most common type or cause - Childhood heart disease in the United States
cDNA libraries are derived from mRNA - are continuous - and contain no introns or regulatory elements.
Liver - kidney - and GI epithelium
Shaping (successive approximation)
Congenital heart disease

17. Is DM a contraindication to use of a Beta- blocker in a patient who is having an MI?
1. Cefamandole 2. Cefoperazone 3. Moxalactam
Absolutely not. Diabetics who are given a Beta- blocker for an acute chest syndrome have significantly better outcomes than those who do not.
Parvovirus
Parvovirus B 19

18. Has proteolytic metabolic effects.
Lateral hypothalamic zone; lesions here result in aphagia. (Notice the difference between the feeding center and the satiety center; they are in different zones.)
Epinephrine
No enzymes are needed. When the stop codon reaches the A site - it results in termination.
Both

19. What virus is associated with both nasopharyngeal carcinoma and Burkitt lymphoma?
EBV
Right and left pulmonary arteries and the ductus arteriosus
C1 - C2 - or C4 deficiency
Gaucher disease

20. What disease has a genetically low level of UDPglucuronate transferase - resulting in elevated free unconjugated bilirubin?

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21. What vertebral level is marked by the xiphoid process?
T9
embranoproliferative glomerulonephritis (MPGN)
Diethylcarbamazine
Hormone secretion for T- cell differentiation and T- cell education to recognize self from nonself

22. In What type of circuit is the total resistance always less than that of the individual resistors?
Global aphasia
Systemic lupus erythematosus
Parallel circuit
Phase II

23. What is the most likely organism causing cellulitis in a patient who was cut by an oyster shell?
Magnesium
Hydatidiform mole
The urine becomes hypertonic because of water reabsorption in the collecting duct.
Vibrio vulnificus

24. What is the name for inability to stop a movement at the intended target?
Type II symptoms (negative); otherwise healthy persons have them - but schizophrenics do not.
Dysmetria; this is seen in a finger - to - nose test.
One - way ANOVA
Oncotic pressure increases because of the removal of water.

25. Where are the LMN cell bodies of the corticospinal tract?
In the ventral horn of the spinal cord. UMN cell bodies are in the precentral gyrus of the frontal lobe.
Stimulus generalization must stop. (Pairing of the unconditioned stimulus and the conditioned stimulus must cease.)
The fastigial nucleus
Uracil

26. Where are the tonsillar tissues?

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27. What ethnic group has the highest adolescent suicide rate?
Osteocyte
Listeria monocytogenes
The surface of the medulla
Native Americans

28. What is the only diuretic that works on the blood side of the nephron?
Passive - aggressive
Wilson's disease (Remember chromosome 13 and hepatolenticular degeneration)
Spironolactone (binds to aldosterone receptors)
The fasciculus gracilis (Graceful) - which lies closest to the midline of the spinal cord.

29. What segments of the lumbosacral plexus form the following nerves? - Femoral nerve
L2 to L4 (L2 to L4 - thigh; L4 to S3 - leg)
Patau syndrome (trisomy 13)
Size
Anxiety disorders; for men it is substance abuse.

30. What Brodmann area is associated with x Somatosensory association cortex?
Areas 5 and 7
NO!! Remember - only a judge can commit a patient. A physician can detain a patient (maximum is for 48 hours).
Subdural hematoma is a rupture of the cerebral veins where they enter the superior sagittal sinus.
Y - W-135 - and C and A capsular polysaccharides

31. As what AAs do muscles send nitrogen to the liver?
Alanine and glutamine
Papillary carcinoma of the thyroid
Axon hillock
Because it is the largest vessel and has the highest velocity in systemic circulation

32. Is a brush border enzyme.
First - order elimination
Enterokinase
Osteoblasts (Remember - they modulate the function of osteoclasts.)
gp120

33. Name the GLUT transporter based on the following: x Found in skeletal muscle and adipose tissues
GLUT 4
urease positive
Succinate dehydrogenase
The vestibulo - ocular reflex

34. How much of a vessel must be stenosed to cause sudden cardiac death?
Urogenital folds
More than 75% of the vessel
EF- Tu or EF- ts and GTP
Increased REM sleep - decreased REM latency - and decreased stage 4 sleep - leading to early morning awakening

35. What is the term for conversion of a dsDNA molecule to the base sequence of an ssRNA molecule?
IgA deficiency; patients commonly present with recurrent sinopulmonary infections and GI disturbances.
Yes - as long the illness does not threaten limb or life. If illness is critical or an emergency - treat the child.
Transcription (C comes before L in the alphabet - and transCription comes before transLation)
Menstruation

36. What is the MCC of death in children aged 1 to 14 in the United States?
Kimmelstiel - Wilson disease
Histamine
Accidents
Hemiazygous vein

37. What bacterium is responsible for woolsorter's disease?
Bacillus anthracis
IgA nephropathy (Berger disease)
Nystagmus and ataxia
Histrionic

38. What oral hypoglycemic agent should be used with caution in patients with CHF because it causes lactic acidosis?
Metformin
Hemophilia B
Resistance decreases as resistors are added in parallel.
common variable hypogammaglobinemia

39. What attaches the cusps of the valves to the papillary muscles in the heart?
Brother Fox (Eichner vs. Dillon). The substituted standard could not apply because the patient had never been competent - so no one knew What the patient would have wanted. Therefore - the decision was based on What a 'reasonable' person would have w
Renal cell carcinoma
Permanent
Chordae tendineae

40. From what pharyngeal groove is the external auditory meatus derived?
First pharyngeal groove; all others degenerate.
Phallus
Anatomical dead space - which ends at the level of the terminal bronchioles.
1. Sartorius 2. Gracilis 3. Semitendinous

41. What inhibitor of microtubule synthesis is the drug of choice for whipworm and pinworm?
Mebendazole
Yes. (Remember - Jehovah's witnesses refuse blood transfusions.)
Initiate and manage gross skeletal muscle movement control
Absolutely not! Answer any question you are asked.

42. Name the Plasmodium species based on the following information:Persistent hypnozoite liver stage with relapses; blood smear shows amoeboid trophozoites with oval - jagged infected RBCs; 48- hour fever spike pattern
IgM
The interposed nucleus
Plasmodium ovale
Gaucher disease

43. What causes slow writhing movements (athetosis)?
Both Neisseria and Moraxella are gram - negative cocci.
Hormone - sensitive lipase
Affinity decreases; they are inversely proportional.
Hypermyelination of the corpus striatum and the thalamus (seen in cerebral palsy)

44. What three things are needed to produce a double bond in a fatty acid chain in the endoplasmic reticulum?
NADPH - O2 - and cytochrome b5
Hypervariable region (three per light chain; three per heavy chain)
Effective dose for 50% of drug takers (median effective dose)
Wegener granulomatosis

45. Methylating uracil produces what pyrimidine base?
Expiratory reserve volume (ERV)
Preload. It is the load on a muscle Prior to contraction.
Thymine
1. a - Ketoglutarate dehydrogenase 2. Pyruvate dehydrogenase 3. Transketolase Thiamine pyrophosphate (TPP) functions as a coenzyme vital to tissue respiration. It is required for the oxidative decarboxylation of pyruvate to form acetyl - coenzyme A -

46. In the water deprivation test - does a patient with reduced urine flow have primary polydipsia or diabetes insipidus?
Brain abscess
Primary polydipsia; patients with diabetes insipidus will continue to produce large volumes of dilute urine.
MEN II and III syndromes
Hypertrophic cardiomyopathy (hypertrophic subaortic stenosis - or IHSS)

47. Does alcoholism increase the rate of suicide?
Coagulative
Yes. It increases the rate of suicide to nearly 50 times that of the general population.
Basophilic stippling
Sheehan syndrome

48. Which class of antiarrhythmics are potassium channel blockers?
Yohimbine
Class III
Bisphosphonates
Infrapatellar bursa

49. Indicates the patient has active pulmonary disease.
Factitious disorder
A positive PPD skin test
Bronchiectasis
Round and ovarian ligaments

50. What is the relationship between chance of error and x Sample size?
Dilation of afferent arteriole
Rhombencephalon
The Purkinje cell
As sample size increases - the lower the chance of error.

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USMLE Step 1 Prep

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