Test your basic knowledge |

USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which two antipsychotic drugs create a high risk for developing extrapyramidal syndrome (EPS) side effects?
Utricle and saccule
Ungated channels
Haloperidol and fluphenazine (but use of any high - potency phenothiazine runs the risk of EPS)
Lipoid nephrosis

2. What substance is used to test platelets' response in patients with von Willebrand disease?
Ristocetin
Western blot
Hgb F
Dominant parietal lobe (Gerstmann's syndrome)

3. What type of bias is it when the information is distorted because of the way it is gathered?
Measurement bias
Gonads
Right and left pulmonary arteries and the ductus arteriosus
Beta- Endorphin

4. Name the correct artery - The right recurrent laryngeal nerve passes around it.
CN V
Right brachiocephalic artery
Type I pneumocytes
Positive sense RNA means it can serve as mRNA and therefore has 5'-3' polarity

5. What is the major Ig of the secondary immune response in the mucosal barriers?
IgA
Formal operations (> 12 years)
Kinesins. Dynein generates retrograde transportation of information.
Monocytosis

6. What is the best measure of total body vitamin D if you suspect a deficiency?
Diphyllobothrium latum
Severe combined immunodeficiency disease
Serum 25- hydroxy- vitamin D (25- OH- D)
Coxsackie A

7. Name the antidote - Copper
D- Penicillamine
igantism
Chloramphenicol
Urogenital sinus

8. What testicular tumor of infancy is characterized by elevated - fetoprotein levels and Schiller - Duval bodies?
Knee
A low - resistance system is formed by resistors added in parallel.
Dorsal spinocerebellar tract; the accessory cuneate nucleus is the second nucleus for the cuneocerebellar tract.
Yolk sac tumor

9. What female follicular cell is under LH stimulation and produces androgens from cholesterol?
Megaloblasts
Fructose; both glucose and galactose are actively absorbed via secondary active transport.
Elevated ASO titers and serum complement levels
Theca cell

10. If you double the infusion rate of a drug - how long will it take to reach steady state?
They chronically inhibit ADH secretion; when there is a decrease in the blood volume - the stretch receptors send fewer signals - and ADH is secreted.
Regardless of the rate of infusion - it takes 4 to 5 half - lives to reach steady state.
Macule (e.g. - a freckle)
Empyema

11. What two cell lines of the immune system do not belong to the innate branch?
T and B- cells belong to the adaptive branch - whereas PMNs - NK cells - eosinophils - macrophages - and monocytes belong to the innate branch.
Because the venous system is more compliant than the arterial vessels - small changes in pressure result in large changes in blood volume.
T lymphocyte
Good Samaritan Law. (Physicians are not required to stop and help.)

12. What is the term for air in the pleural space?
Stereocilia
Turcot syndrome
Pneumothorax
Gastric cancer

13. What malignant bone tumor is associated with familial retinoblastoma?
Early collecting duct
Osteosarcoma
Phase 0
No. Remember - tests do not diagnose - they confirm or refute your diagnosis. Also - diagnosis of MI requires two of three criteria: chest pain consistent and characteristic of MI - elevated cardiac enzymes consistent with MI - and ST segment elevati

14. What three carcinomas are associated with EBV?

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

15. What is the lymphatic drainage of the pelvic organs?
Pernicious anemia (secondary to a lack of vitamin B12 absorption)
Ventral posteromedial nucleus
Doxycycline
Internal iliac nodes

16. What is the MCC of the following endocarditis scenarios? - Following biliary infections
Hypocalcemia and hypophosphatemia
The Beta- subunit; remember - the a - subunit is nonspecific.
Enterococcus faecalis
Internal abdominal oblique

17. Name the lipoprotein based on the following characteristics - apo A-1 - apo E - apo C- II
Fibrocystic change of the breast
Hyaluronic acid (all sulfates bind to the core protein)
HDL
MHC class II Ags. This is accomplished via CD4 T cells.

18. Name the primary vesicle the following structures are derived from (proencephalon - mesencephalon - or rhombencephalon) - Myelencephalon
Alcohol abuse
If the ratio of the filtrate to plasma concentration of a substance is equal - the substance is freely filtered by the kidney.
Rhombencephalon
The aorta has the greatest velocity and the capillaries have the slowest velocity.

19. What is the name of the T cell - rich area of the lymph node?
Paracortex
Vancomycin
ll
Laminin

20. Name the cancer associated with the following oncogenes. (Some may have more than one answer) x erb -1
Four Ms and a U 1. Median 2. Medial antebrachial 3. Medial pectoral 4. Medial brachial cutaneus 5. Ulnar
Labile
Creutzfeldt - Jakob's disease. Patients first develop vague somatic complaints and anxiety - rapidly followed by dysarthria - myoclonus - ataxia - and choreoathetosis.
Squamous cell carcinoma of the lung

21. How many ATPs are produced from cytoplasmic NADH oxidation using the glycerol phosphate shuttle?
2 ATPs by oxidative phosphorylation
Yolk sac tumor
Free - unprocessed Ag
Langerhans cells

22. Name the T- cell CD marker: x Expressed on all T cells and is needed as a signal transducer for the T cell receptor
HMG- CoA reductase
Ligamentum arteriosum
CD3
MEN IIa (or Sipple syndrome)

23. Name the most common type or cause - Acute metal poisoning in the United States
Respiratory distress syndrome; treatment with cortisol and thyroxine can increase production of surfactant.
Syncytiotrophoblast. (The cytotrophoblast gets incorporated into the syncytiotrophoblast.)
Arsenic
Positive

24. What tract is responsible for voluntary refined movements of distal extremities?
Orotic acid (purine metabolism)
Dissociation
Corticospinal tract
Femoral nerve

25. What area of the hypothalamus is the feeding center?
Dimorphic
Nasopharynx
Lateral hypothalamic zone; lesions here result in aphagia. (Notice the difference between the feeding center and the satiety center; they are in different zones.)
Thyroid hormones

26. What leukemia is associated with four - leaf - clover lymphocytes on peripheral blood smear?
Type IV collagen
Celiac - aorticorenal - and superior mesenteric ganglias. (Remember all ' Splanchnics' are Sympathetic except for the Pelvic splanchnics - which are Preganglionic Parasympathetic fibers.)
Streptococcus agalactiae
Adult T- cell leukemia

27. Does the left or right vagus nerve innervate the SA node?
Primary hypoaldosteronism (Addison's disease)
Kupffer cells
Secondary hyperparathyroidism (vitamin D deficiency - renal disease)
Right vagus innervates the SA node and the left vagus innervates the AV node

28. What is the T- cell area of the spleen?
Teratoma (dermoid cyst)
Smoking
Oxazepam - temazepam - and lorazepam (OTL) (mnemonic: Outside The Liver). They undergo glucuronide conjugation - not via the cytochrome p450 system.
PALS

29. What is the label given to an individual whose IQ is x 110 to 119
HDL
Anemia
No. It is abnormal only if it interferes with normal sexual or occupational function.
High average

30. What type of hepatitis has the highest mortality rate among pregnant women?
RNA polymerase I
VLDLs
Mesencephalic nucleus
Hepatitis E

31. What adrenergic receptors use inositol triphosphate (IP3) and diacylglycerol (DAG) for their second messenger system?
CD40
Congenital heart disease
Ethacrynic acid
a1- Receptors

32. Which subset of MEN syndrome is associated with the following? - Parathyroid - pancreatic - and pituitary gland tumors and Zollinger - Ellison syndrome
Functionally they are part of the left lobe of the liver because they receive their blood supply from the left hepatic artery. Anatomically they are considered part of the right lobe of the liver.
Arginine
Amyl nitrate - sodium nitrate - or sodium thiosulfate
MEN I (or Wermer syndrome)

33. Does physiologic splitting of the first heart sound occur during inspiration or expiration? Why?
There are 10 bronchopulmonary segments on the right and 8 on the left.
von Hippel - Lindau syndrome
First - pass effect
Splitting of the first heart sound occurs during inspiration because of the increased output of the right ventricle - delaying the closure of the pulmonic valve.

34. What protein deficiency results in respiratory distress syndrome of newborns?
Deficiency in surfactant
Choriocarcinoma
Dilation of afferent arteriole
Processed antigenic peptides bound in the groove of the MHC molecule

35. Which potassium - sparing drug is an aldosterone receptor antagonist ?
Mycoplasma
naked viruses
Ventromedial nucleus; lesions here result in obesity.
Spironolactone

36. What is the term for the proportion of a drug that reaches systemic circulation?
Asbestosis
Graves disease
HPVs 16 and 18
Bioavailability

37. What vessel does the right gonadal vein drain into?
Tolcapone and entacapone
1. Cloxacillin 2. Oxacillin 3. Nafcillin 4. Dicloxacillin 5. Methicillin (CONDM)
The right gonadal vein drains into the inferior vena cava directly - and the left gonadal vein drains into the left renal vein.
Being a white male

38. What is the only nonmotile pathogenic Clostridium species?
Beta2- Adrenergic agents
Yes
Free - unprocessed Ag
Clostridium perfringens

39. What is the most common one? - Primary malignant tumor of the lungs
Gerstmann's syndrome; spoken language is usually understood.
Bladder carcinoma
Hypermyelination of the corpus striatum and the thalamus (seen in cerebral palsy)
Adenocarcinoma (30% to 35%)

40. What is the term for the number of new events occurring in a population divided by the population at risk?
18 years old (except if emancipated)
Osteoclasts
Aldehyde dehydrogenase
Incidence rate

41. What DNA viral disease is associated with aplastic crisis in patients with sickle cell anemia?
Glycogen synthase
Paracortex
Minocycline
Parvovirus B-19

42. What is the primary risk factor for suicide?
Previous suicide attempt
Klatskin tumor
Risk factors for breast cancer
Leucine and lysine

43. What papillae are touch receptors on the tongue and send their sensations via CN V3 (mandibular division)?
Filiform papillae
Pulmonary infections
Type II hypersensitivity (cytotoxic)
Cingulate gyrus herniation (subfalcine)

44. What is the primary end product of pyrimidine synthesis?
Cholera toxin irreversibly activates the cAMP- dependent chloride pumps of the small and large intestine - producing a large volume of chloride - rich diarrhea.
Dorsal prefrontal cortex
UMP
At birth (reflex)

45. Of what serotonin receptor is sumatriptan an agonist?
Metastatic
5HT1D
The right gonadal vein drains into the inferior vena cava directly - and the left gonadal vein drains into the left renal vein.
Leucine and lysine

46. The first sensory neuron is in the dorsal root ganglia. It carries ascending sensory information in the dorsal root of a spinal nerve - eventually synapsing with second sensory neuron. In the brainstem (DCML) and the spinal cord (spinothalamic) the s
The stomach
Positive reinforcement
Where the cell bodies for the DCML and spinothalamic sensory systems are...
1. The lesser omentum (consisting of the hepatoduodenal and hepatogastric ligaments) 2. Falciform ligament 3. Coronary ligament of the liver 4. Triangular ligament of the liver Liver is ventral; all other ligaments are dorsal mesentery derivatives.

47. What catecholamine - hypersecreting tumor - a secondary cause of HTN - results in headache - diaphoresis - anxiety - tachycardia - and palpitations?
Pheochromocytoma
Osteoblast (Remember - blasts make - clasts take)
Target cell
Juxtaglomerular (JG) cell

48. When a person goes from supine to standing - what happens to the following? - Cardiac output
Niemann - Pick disease
Alveolar macrophages (dust cells)
Decreases Remember - the carotid sinus reflex attempts to compensate by increasing both TPR and heart rate.
The poly(A) site on the DNA

49. Name these cluster A personality disorders: x Odd - strange; has magical thinking; socially isolated - paranoid - lacks close friends; has incongruous affect
Chorda tympani of CN VII
Insulin increases intracellular K+ stores while decreasing serum K+ levels.
Schizotypal
TB meningitis

50. What is the only enzyme in the body that uses N-5- methyl folate?
1. Decrease concentrations of Ag levels 2. Administer IgG in high concentrations 3. Inhibit B cells with Ag bound to IgG (complexes) 4. Turn off the original T or B cell with anti - Ab
Pneumocystis carinii
Superior rectus (CN III) (LR6 SO4)3
Homocysteine methyl transferase