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Test your basic knowledge |
USMLE Step 1 Prep
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Name the area of the cerebral cortex with the function described: x Speech; critical for personality - concentration - initiating and stopping tasks (do one thing and begin a new without completion of the first) - abstract thought - and memory and hi
Toxoplasmosis (although you should rule out cerebral abscess due to other organisms)
45XO
Frontal lobe
At least six
2. Using Laplace's relationship regarding wall tension - why is the wall tension in an aneurysm greater than in the surrounding normal blood vessel's wall?
The wall tension is greater because the aneurysm has a greater radius than the surrounding vessel.
Pulmonary embolism due to a DVT; this is not absolute but a classic description.
The right and left pulmonary arteries - the only arteries that carry deoxygenated blood
Bacillus anthracis
3. What is the name of the major chemotactic agent released from x Bacteria?
Breast cancer
F- Met - Peptides
Psoas major
Labetalol
4. What agent used in the treatment of BPH and baldness is a 5- a - reductase inhibitor?
Collecting ducts - which make them readily permeable to water reabsorption.
Dominant temporal lobe
31 pairs
Finasteride
5. What syndrome is due to a deficiency of surfactant?
Clindamycin
Priapism
Respiratory distress syndrome; treatment with cortisol and thyroxine can increase production of surfactant.
Conus arteriosus of the right ventricle and right and left auricles
6. The opening of what valve indicates the termination of isovolumetric relaxation phase of the cardiac cycle?
Opening of the mitral valve indicates the termination of the isovolumetric relaxation phase and the beginning of the ventricular filling phase.
NAVEL: Femoral Nerve - Artery - Vein - Empty space - and Lymphatics/Lacunar ligament
Farnesyl pyrophosphate (FPP)
10% are bilateral - 10% malignant - and 10% familial - 10% in children - and 10% outside the adrenal gland
7. Name the thalamic nucleus based on its input and output - Input from the optic tract; output projects to the primary visual cortex of the occipital lobe
Beta- Blockers
Absolute refractory period is due to voltage inactivation of sodium channels.
ACh
LGB (think EYES)
8. What is used as an index for both adrenal and testicular androgens?
Urinary 17- ketosteroids
Stereocilia
No CHO - AA - ketones - or peptides are left in the tubular lumen.
Achalasia
9. What two post - transcriptional enzymes in collagen synthesis require ascorbic acid to function properly?
1. Inhibin 2. Estradiol (E2) 3. Androgen - binding protein 4. Meiosis inhibiting factor (in fetal tissue) 5. Antim
Positive
Marijuana
Prolyl and lysyl hydroxylases
10. Name the cancer associated with the following oncogenes. (Some may have more than one answer) x hst -1 - int -2 - erb -2 - and erb -3
Progressive multifocal leukoencephalopathy
Sarcoidosis
Breast cancer
Carbamoyl phosphate synthetase I
11. What adult structures are derived from preotic somites?
CD40
Toxoplasma gondii
HMP shunt
Muscles of the internal eye
12. What is the term for headaches - inability to concentrate - sleep disturbances; avoidance of associated stimuli; reliving events as dreams or flashbacks following a psychologically stressful event beyond the normal range of expectation?
Posttraumatic stress disorder. (Important: symptoms must be exhibited for longer than 1 month.)
Bioavailability
Trisomy 12 (nearly 50% of patients with CLL have abnormal karyotypes.)
Mesonephric duct
13. Name the area of the cerebral cortex with the function described: x Language - memory - and emotion (Hint: herpesvirus infects here commonly)
Temporal lobe
Promotes systemic venous return into the chest and increases the caliber and volume of the pulmonary vessels
Guanethidine and bretylium
Superior colliculus (Remember S for Superior and Sight). The inferior colliculus processes auditory information from both ears.
14. Name the hepatitis virus based on the following information - Naked capsid RNA picornavirus
Hepatitis A
Nasal polyps - rhinitis - and aspirin hypersensitivity
Medial nuclear group (limbic system)
Chronic alcoholic
15. To differentiate central from nephrogenic diabetes insipidus - after an injection of ADH - which will show a decreased urine flow?
Central. Remember - there is a deficiency in ADH production in the central form.
Kayser - Fleischer rings
Autoimmune hemolytic anemia
Ag - Ab binding
16. What CNS demyelinating disease is characterized by diplopia - ataxia - paresthesias - monocular blindness and weakness - or spastic paresis?
Beta2- Adrenergic agents
Case control studies cannot assess incidence or prevalence - but they can determine causal relationships.
In the peroxisome until it is 10 carbons long; the rest is completed in the mitochondria.
Multiple sclerosis
17. What is the neurotransmitter at the K- receptor?
Dynorphin
Hemiazygous vein
No - it is never acceptable to lie.
Caplan syndrome
18. By What age should children be able to draw the following figures? - Diamond
Extravascular hemolysis if it occurs in the spleen; if in the liver - it results in hepatomegaly.
Glucose
Spermatogonia (type B)
7 years old
19. Is Dubin - Johnson or Rotor syndrome associated with black pigmentation of the liver?
Ritodrine and terbutaline
Both are AR with conjugated hyperbilirubinemia - but Dubin - Johnson syndrome is differentiated from Rotor by the black pigmentation of the liver.
Clostridium perfringens
Nitroblue tetrazolium reduction test (NBT). It is negative in patients with CGD because there is no production of oxygen radicals.
20. Name the cancer associated with the following oncogenes. (Some may have more than one answer) x Ki - ras and erb -2
Lung cancer
Marrow failure - cancer - and leukemia
6 ATPs (remember 2 pyruvates per glucose are produced - and 2 NADHs result from production of acetyl CoA - so 6 ATPs)
CN IX and X
21. How many pairs of spinal nerves are associated with x Sacral vertebrae?
1. Fat 2. Forty 3. Female 4. Familial 5. Fertile
Epinephrine
None. Denaturation of dsDNA breaks hydrogen bonds - not covalent bonds.
Five pairs through five sacral vertebrae. Totaling 31 pairs of spinal nerves.
22. What tumor is seen in the 2- to 4-year - old age group; does not cross the midline; has immature glomeruli - tubules - and stroma; and metastasizes late to the lungs?
Wilms tumor
Reserpine
Transmembrane potential (an absolute number)
B- cell Ag receptors
23. Are reabsorbed in the gallbladder.
Bile pigments and bile salts
SLE; ANA - anti - dsDNA and anti - Sm (anti - Smith)
Peroxidase - Which is also needed for iodination and coupling inside the follicular cell
Male pseudo - intersexuality (hermaphrodite); these individuals are 46XY.
24. What type of lysosome is formed when lysosome fuses with a substrate for breakdown?
Metronidazole
Secondary lysosome (think of the primary as inactive and secondary as active)
Cystadenocarcinoma
>10 mm
25. Because of their vasodilation action - these cause migraines.
Ergotamines
Efficacy
NADPH and molecular O 2
Parasympathetics (parasympathetics point - sympathetics shoot)
26. Name the primary vesicle the following structures are derived from (proencephalon - mesencephalon - or rhombencephalon) - Cerebral hemispheres
Proencephalon
Frontal lobe syndrome (lesion in the prefrontal cortex)
Ciliary ganglion
well - fed and fasting
27. What CN is associated with the x Third pharyngeal arch?
CN IX
Nitroblue tetrazolium reduction test (NBT). It is negative in patients with CGD because there is no production of oxygen radicals.
Kartagener's syndrome (also known as immotile cilia syndrome) -------------------------------------------------------------------------------
Parental assignment and culture (not biology)
28. What component of the trigeminal nuclei x Supplies the muscles of mastication?
The urea cycle
Motor nucleus of CN V
Cytochrome b/c1
Proencephalon diencephalon derivative
29. What enzyme catalyzes the rate - limiting step in gluconeogenesis?
Right and left pulmonary arteries and the ductus arteriosus
O2 affinity increases with a decrease in the p50 - making O2 more difficult to remove from the Hgb molecule.
Fructose -1 - 6- bisphosphatase
Theca cell
30. What enzyme of the TCA cycle catalyzes the production of the following: x FADH2
Macrophages
Succinate dehydrogenase
Third week; they are derived from the wall of the yolk sac.
Bronchogenic carcinoma
31. What are the five pieces of information considered necessary for fully informed consent?
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32. What is the term for a congenital absence of the ganglionic cells of the Auerbach and Meissner plexus in the rectum and sigmoid colon?
Cryptococcus
Hirschsprung disease (aganglionic megacolon)
They are in the grey matter of the CNS.
Pseudomembranous exudates
33. What is the period between going to bed and falling asleep called?
A low - resistance system is formed by resistors added in parallel.
1. Malate dehydrogenase 2. Isocitrate dehydrogenase 3. a - Ketoglutarate dehydrogenase
Sleep latency
Capillaries
34. If the pH is low with increased CO2 levels and decreased HCO3- levels - What is the acid - base disturbance?
Anemia of chronic disease
Areas 1 - 2 - and 3
Combined metabolic and respiratory acidosis
The Purkinje cell
35. What are the five AAs that are both ketogenic and glucogenic?
Isoleucine - threonine - tryptophan - tyrosine - and phenylalanine
Immature B cells
Mercury
C1 inhibitor (C1- INH)
36. What embryonic structure forms the adult female structures? - Ovarian and round ligaments
The central vein of the liver lobule
Gubernaculum
GnRH constant infusion
Adenovirus
37. What is the most common one? - Benign GI tumor
Leiomyoma
Increase (5- HT and dopamine levels do the same)
Gradient - time system
Waldeyer's ring
38. What drug is used to prevent alcohol consumption by blocking aldehyde dehydrogenase?
Aorta - azygos vein - and thoracic duct Remember: 1 at T8 - 2 at T10 - and 3 at T12
Leydig cell tumor
Conduction aphasia
Disulfiram
39. What is the term for failure to give up infantile patterns of behavior for mature ones?
PALS
Fixation (arrested development)
Lateral collateral ligament
Hepatic glycogen phosphorylase
40. How do delusions - illusions - and hallucinations differ?
Hallucinations are sensory impressions (without a stimulus); illusions are misperceptions of real stimuli; and delusions are false beliefs that are not shared by the culture.
Metastatic carcinomas
Streptococcus pneumoniae
Melanoma - cancer of the stomach and bladder
41. What are the two most common chains of the TCR?
Without children (but don't think about this one for too long)
Coombs test
Low average
a - and Beta- chains are on most T cells.
42. What is the treatment for nephrogenic diabetes insipidus induced by lithium?
Conjugated (direct) hyperbilirubinemia
Hypokalemic metabolic alkalosis occurs from vomiting because of the loss of H+ - K+ - and Cl -.
Diethylcarbamazine
Amiloride
43. A 60-year - old man has back pain (compression spinal fracture) - hypercalcemia - increased serum protein - Bence - Jones proteinuria - and monoclonal M- spike on serum electrophoresis. What is your diagnosis?
Multiple myeloma
Parafollicular C cells
Roth spots - and they are seen in bacterial endocarditis.
Pneumococcus (Streptococcus pneumoniae)
44. Influenza - Vibrio cholera - hepatitis A - rabies - and adenovirus.
Tetany
The sensory component is through the superior laryngeal nerve - and the motor limb is via the recurrent laryngeal nerve.
Are inactivated vaccines available in the United States
excites the neuron
45. What bedside test is used to differentiate a dorsal column lesion from a lesion in the vermis of the cerebral cortex?
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46. What hormone - produced by the granulose cell - stimulates the endometrium to enter the proliferative phase?
Estrogen; the first 14 days of the female reproductive cycle mark the proliferative phase.
Clostridium botulinum
The mouth
Paracortex
47. With what stage of sleep are night terrors associated?
Pick's disease
NREM sleep. Night terrors are dreams that we are unable to recall.
Omphalocele and gastroschisis
Duodenal atresia
48. Indicates the patient has active pulmonary disease.
DiGeorge's syndrome
The inner membrane of the mitochondria (cristae)
Neonatal respiratory distress syndrome (NRDS)
A positive PPD skin test
49. Name the type of mutation: x Unequal crossover in meiosis with loss of protein function
Large segment deletions
Convergence
Dihydrofolate reductase
Ligament teres
50. Name the type of exudate - given the following examples - Diphtheria infection
Klebsiella pneumoniae
Pseudomembranous exudates
Breast cancer
Human chorionic somatomammotropin (hCS) or human placental lactogen (hPL)
Can you answer 50 questions in 15 minutes?
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