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USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Name the RNA subtype based on the following: x RNA molecules with enzymatic activity
They are in the grey matter of the CNS.
Caseous necrosis
Ribozymes
Superior

2. Name the DNA virus: x Circular dsDNA; naked; icosahedral; replicates in the nucleus
CD19
Papovavirus
LH
One day after the LH surge and 2 days after the estrogen peak.

3. What three major cell lines participate in the acquired immune system?
T cells - B cells - and macrophages
Somatomedins
Pancreatic cancer
C4 (the upper border of the thyroid cartilage)

4. What cell converts androgens to estrogens?
Sideroblastic anemia
Thermogenic
IgG
Granulosa cell

5. What is the most common site for implantation of the blastocyst?
Type I hypersensitivity (anaphylactic)
Hypoparathyroidism
On the superior body of the posterior wall of the uterus
Papillary carcinoma of the ovary

6. Name the muscle type based on the histological features: x Actin and myosin in sarcomeres; striated; uninuclear; gap junctions; troponin:calcium binding complex; T tubules and SR forming dyadic contacts; voltage - gated calcium channels
2 acetyl CoA per glucose - producing 12 ATPs per acetyl CoA - resulting in a total of 24 ATPs produced from glucose (via acetyl CoA) enter the TCA cycle
Diazoxide
Somatization
Cardiac muscle

7. Induces the cytochrome P-450 enzymes.
Thyroid gland
Ethyl alcohol
The vagina
Teratoma (dermoid cyst)

8. Codman triangle on radiograph
Osteosarcoma
Alzheimer disease
Carbamoyl phosphate synthetase I
Protamine sulfate

9. What are the four functions of SER?
Nitrofurantoin
Steroid synthesis - drug detoxification - triglyceride resynthesis - and Ca2+handling
Ethyl alcohol
Posterior compartment of the leg - tibial nerve

10. Name the aphasia based on these characteristics: x Lesion is in the parietal lobe or arcuate fibers because the connection between Broca's and Wernicke's area is severed; word comprehension preserved; inability to write or speak the statement (can't
Hydatidiform mole
Metronidazole
Hapten; if it is coupled with a carrier - it may become immunogenic.
Conduction aphasia

11. How are pulse pressure and compliance related?
Nocardia asteroides
Stage 2 - which accounts for approximately 45% of total sleep time - with REM occupying 20%.
They are inversely proportional to each other; as pulse pressure increases - compliance decreases.
PRPP aminotransferase

12. What is the drug of choice for treating ADHD?
Shifts it to the right
Hematoxylin
Methylphenidate (Ritalin)
T cells - not B cells

13. What is the only muscle of the soft palate that is innervated by CN V3?
Hypertension
Exogenous steroids suppress LH release and result in Leydig cell atrophy. Testosterone - produced by Leydig cells - is needed for spermatogenesis.
Flumazenil
The tensor veli palatine is innervated by the mandibular division of the trigeminal nerve; all others are innervated by CN X.

14. What is a plasma cell's life expectancy?
7 to 14 days
1. Skin 2. Liver 3. Kidney
Argyll Robertson pupils
Femoral hernias

15. Increases the risk of developing ovarian cancer.
Tidal volume (VT)
Gardnerella vaginalis
Estrogen use
Spironolactone

16. What is the most common one? - Site of ischemia in the GI tract
All
1. TTP 2. Lipoic acid 3. Coenzyme A from pantothenate 4. NAD(H) (from niacin or tryptophan) 5. FADH2 (from riboflavin)
Splenic flexure
Meningococcus grows on chocolate agar - and Gonococcus grows on Thayer - Martin medium.

17. Megaloblastic anemia and thrombocytopenia are signs of what vitamin deficiency?
Ampulla
Erythema marginatum
Folic acid deficiency
Afterload

18. What agent is used IM to treat acute dystonias?
Yes. In a negatively skewed distribution the mean is greater than the median is greater than the mode.
Diphenhydramine
Glycogen synthase
Arsenic

19. What scale has a true zero point - graded into equal increments - and also orders them?
Ratio scale
False - negative rate
Dimercaprol - penicillamine
Acetyl CoA and propionyl CoA (in odd chain fatty acids)

20. What form of nephritic syndrome is associated with celiac sprue and Henoch - Sch
Picornaviridae
IgA nephropathy
Brain abscess
X- linked dominant

21. Which encapsulated fungus is found in soil enriched with pigeon droppings?
Cryptococcus neoformans
Type IV collagen
Succinyl CoA
Ristocetin

22. What is the term for making up stories regarding past experiences because of an inability to retrieve them?

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23. What three AAs are used to synthesize the purine ring?
1. Glycine 2. Aspartate 3. Glutamine
Schizoid
Heparin - intrinsic pathway - PTT; warfarin - extrinsic pathway - PT (mnemonic: hPeT - wPiTT)
Opening of the aortic valve terminates the isovolumetric phase and begins the ejection phase of the cardiac cycle.

24. Which leukotriene is chemotactic for neutrophils?
hCG
LTB4
Body dysmorphic disorder
Molindone

25. What enzyme of heme synthesis is deficient in the autosomal dominant disorder acute intermittent porphyria?
Alanine and glutamine
Biotin. Avidin is found in raw egg whites.
Uroporphyrinogen - I synthase
Leukemias

26. What is the titratable acid form of H+ in the urine?
H2PO4- (dihydrogen phosphate)
Rapid efflux of potassium
The CD4 T cell; the APC is the first cell in the immune response.
No. It is abnormal only if it interferes with normal sexual or occupational function.

27. What is the binding site for RNA polymerase?
Group A Beta- hemolytic streptococci
Vitamin K deficiency has normal bleeding time and increased PT - and vitamin C deficiency has increased bleeding time and normal PT.
The promoter indicates where transcription will begin.
Ventricular fibrillation (V fib)

28. What class of drugs is used in the treatment of demineralization of the bone?
Estriol
Bisphosphonates
HBcAb and HBeAb. You see the antibodies c and e.
IgA nephropathy (Berger disease)

29. What IV- only agent inhibits water reabsorption in the PCTs and is used to treat increased intracranial pressure - increased intraocular pressure - and acute renal failure?
Mannitol
Malignant mesothelioma
Internal carotid artery and sympathetic plexus
N- Acetylcysteine

30. Name the phase of the ventricular muscle action potential based on the following information: x Slow channels open - allowing calcium influx; voltage - gated potassium channels closed; potassium efflux through ungated channels; plateau stage
Streptococcus pneumoniae - Klebsiella pneumoniae - Haemophilus influenzae - Pseudomonas aeruginosa - and Neisseria meningitidis; also Cryptococcus neoformans - a fungus
Grasp proceeds release
apo B-48
Phase 2

31. Name the compartment of the mediastinum associated with the following thoracic structures: Trachea
Lower extremity and lower trunk information travels in the dorsal spinocerebellar tract. The upper trunk and extremity information travels in the cuneocerebellar tract. (Cuneocerebellar and fasciculus cuneatus both apply to upper extremities.)
Vascular dementia. It is characterized as a stepwise deterioration in cognitive function.
Superior
Membranoproliferative glomerulonephritis (MGN)

32. What is the term for the same results achieved again on testing a subject a second or third time?
Oligodendroglioma
Left homonymous hemianopsia
Test - retest reliability
Metformin

33. What happens to the following during skeletal muscle contraction? - I band
Mesocortical area
Copper (Cu+)
Shortens
Prinzmetal variant angina

34. All Proteus species are...
Yersinia pestis
21-Beta- Hydroxylase deficiency leads to hypotension - hyponatremia - and virilization.
urease positive
Variola virus (Smallpox)

35. What GI pathology is associated with a positive string sign - an increase in the number of bloody stools - RLQ pain - skip lesions - terminal ileum most commonly affected - occurrence in women more than men - and an increased thickness of the bowel?
Chromosome 15
Escherichia coli
The one start codon - AUG - in eukaryotes codes for methionine and in prokaryotes formylmethionine.
Crohn disease

36. Increases the effect of digoxin.
Hyperkalemia
ELISA test
Superego
CN VI - VII - and VIII

37. What form of arthritis is associated with calcium pyrophosphate crystals?
Burkitt lymphoma
Trimethoprim
Pseudogout
Insulin

38. What is the most common primary diagnosis resulting in an office visit for males? For females?
Foscarnet
Maxillary artery
Tetralogy of Fallot
For males - HTN; for females - pregnancy.

39. What is the most common one? - Site of Crohn disease
Esophagus and esophageal nerve plexus (CN X) Remember: 1 at T8 - 2 at T10 - and 3 at T12
Kinesins. Dynein generates retrograde transportation of information.
Meningioma
Terminal ileum

40. What cell type of the epidermis functions as antigen - presenting cells?
31 pairs
Langerhans cells (found in the stratum spinosum)
Five pairs through five sacral vertebrae. Totaling 31 pairs of spinal nerves.
Rubor (red) - dolor (pain) - calor (heat) - tumor (swelling); also sometimes there is loss of function

41. What enzyme is deficient in selective T cell immunodeficiency?
Impotence
First - pass effect
Histrionic
Purine nucleoside phosphorylase

42. What genetic defect is characterized by coarse facial features - gingival hyperplasia - macroglossia - psychomotor and growth retardation - club foot - claw hand - cardiorespiratory failure - and death in the first decade of life?
eEF-1
Ag processing; it is needed for class I molecules. Class II molecules have an invariant chain that protects them from breakdown.
I- cell disease is a result of a genetic defect affecting the phosphorylation of mannose residues.
Cytochrome a/a3

43. Name the cancer associated with the following oncogenes. (Some may have more than one answer) x Ki - ras and erb -2
Adenosine deaminase
RSV
Lung cancer
Leydig cells produce testosterone. LH stimulates Leydig cells. (Both start with L.)

44. What two viruses are associated with Reye's syndrome?
Nearly 50% of all reported cases of elderly abuse are due to neglect. Physical - psychological - and financial are other forms of elderly abuse with an overall prevalence rate of 5% to 10%.
Lipoprotein lipase
Aminoglycosides
Varicella virus and influenza virus

45. What drug is given transdermally for chronic pain but can cause chest wall rigidity if given IV?
Phallus
Histoplasma capsulatum
1. Big 2. Bilateral 3. Berry aneurysm
Fentanyl

46. From which two substances are phospholipids made?
Diacylglycerols and phosphatidic acid
Hepatoma and nonseminomatous testicular germ cell tumors
Estrogen; the first 14 days of the female reproductive cycle mark the proliferative phase.
Public speaking (Remember: stage fright)

47. Both submandibular and sublingual glands are innervated by CN VII (facial) and produce mucous and serous secretions. Which one mainly produces serous secretions?
Lethal dose for 50% of drug takers (median lethal dose)
Vitamin B 6 (pyridoxine)
Submandibular gland produces mainly serous and the sublingual gland produces mainly mucous secretions.
Axis V

48. Which CNs are found in the midline of the brainstem?
Pulmonary embolism due to a DVT; this is not absolute but a classic description.
CN I - II - III - VI - and XII Add 1 + 1 = 2 - 1 + 2 = 3 - 1 + 2 + 3 = 6 - 1 + 2 + 3 + 6 = 12
Arch of the aorta and right subclavian artery
Functionally they are part of the left lobe of the liver because they receive their blood supply from the left hepatic artery. Anatomically they are considered part of the right lobe of the liver.

49. What tumor constitutes 40% of testicular tumors in children?
Zinc (Zn) deficiency
Teratoma
Physiologic dead space is the total dead space of the respiratory system.
urease positive

50. What is the term for gastric ulcers associated with increased intracranial pressure?

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