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USMLE Step 1 Prep

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How many months in How many years must a person cough with copious sputum production for the diagnosis of chronic bronchitis to be made?






2. What is the most common one? - Congenital heart defect in adults






3. In what disease is there a genetic absence of UDP- glucuronate transferase - resulting in an increase in free unconjugated bilirubin?






4. What viral infection is known to cause intracerebral calcifications?






5. What law states that an enlarged - palpable gallbladder is more likely due to cancer than stone obstruction?

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6. What disorder is due to a 5-- reductase deficiency - resulting in testicular tissue and stunted male external genitalia?






7. What is the term for the heart's inability to maintain perfusion and meet the metabolic demands of tissues and organs?






8. What oral hypoglycemic agent inhibits a - glucosidase in the brush border of the small intestine?






9. What encapsulated group of nerve endings seen at the muscle - tendon junction responds to an increase in tension generated in that muscle? (This is dropping a box that is too heavy to carry.)






10. Name the cancer associated with the following oncogenes. (Some may have more than one answer) x Ki - ras and erb -2






11. As what compound do the carbons for fatty acid synthesis leave the mitochondria?






12. What stage of sleep is associated with somnambulism?






13. What are the five components of portal HTN?






14. Describe the organism based on the following information: x Alpha - Hemolytic Streptococcus; lysed by bile; sensitive to Optochin






15. What AA is a precursor of the following substances? - GABA






16. What component of the cardiovascular system has the largest blood volume? Second largest blood volume?






17. What is needed to initiate translation?






18. Which fungus is found worldwide on plants - is a cigar - shaped yeast in tissue form - and results in rose gardener's disease?






19. In what X- linked recessive disease is there a decrease in the HMP shunt - along with Heinz body formation?






20. What are the following changes seen in the luminal fluid by the time it leaves the PCT of the nephron? - Percentage of Na+ - Cl - - K+ left in the lumen






21. What area of the posterior aspect of the eye has no photoreceptors?






22. What form of arthritis is associated with calcium pyrophosphate crystals?






23. What are the two most common chains of the TCR?






24. How long is the transit time through the small intestine?






25. What medication is used to help alcoholics avoid relapse by decreasing glutamate receptor activity?






26. What Ig is associated with ADCC for parasites?






27. What are the longest - acting and shortest - acting benzodiazepines?






28. Ventral rami of what cervical nerves constitute the phrenic nerve?






29. What blotting technique uses the following for analysis? - DNA






30. Is a subdural hematoma an arterial or venous bleed?






31. Name the type of mutation: x The deletion or addition of a base






32. What reticular nuclei synthesize serotonin from L- tryptophan and plays a role in mood - aggression - and inducing sleep?






33. What are the primary neurotransmitters at the following sites? - Postganglionic sympathetic neurons






34. What phase of the cell cycle are the following antineoplastic agents specific for? - Alkylating agents






35. What malignant tumor of the skin is associated with Birbeck granules?






36. Hereditary angioneurotic edema (AD) produces local edema in organs (e.g. - GI - skin - respiratory tract). What enzyme deficiency causes increased capillary permeability due to a release of vasoactive peptides?






37. What Beta- blocker is also a membrane stabilizer?






38. What is the term for increased iron deposition resulting in micronodular cirrhosis - CHF - diabetes - and bronzing of the skin?






39. What is the name of the postganglionic parasympathetic ganglion that innervates x The lacrimal gland and oral and nasal mucosa?






40. What pneumoconiosis is associated with exposure to the following occupations or materials? - Miners - metal grinders - and sandblasters

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41. On what chromosome is the adenomatous polyposis coli gene?






42. What are the four ways to increase TPR?






43. What is the term to describe jumping from one topic to the next without any connection?






44. What is the term for the day after the LH surge in the female cycle?






45. What is the most common one? - Germ cell tumor in boys






46. Which overdose carries a higher mortality rate - that of benzodiazepines or barbiturates?






47. What is the main factor determining GFR?






48. What facultative intracellular fungus is associated with hepatosplenomegaly?






49. Where does CHO digestion begin?






50. What syndrome has loss of deep tendon reflexes - muscle weakness - and ascending paralysis preceded by a viral illness?