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USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What ascending sensory system carries joint position - vibratory and pressure sensation - and discriminative touch from the trunk and limbs?
Hyperventilation - which decreases CO2 - shifting the reaction to the left and decreasing H+
Area 17
The DCML system. (Remember - everything but pain and temperature.)
Myasthenia gravis

2. What artery travels with the following veins? - Middle cardiac vein
Thyroid hormones
Posterior interventricular artery
Tetracyclines
In the first and second bronchi

3. What is the term for tissue - based basophils?
Squamous cell carcinoma
Mast cells
Wernicke's aphasia
Maxillary artery

4. What hormone excess produces adrenal hyperplasia?
ACTH
Negative
Streptococcus viridans
Bernard - Soulier syndrome

5. Name the type of mutation: x New codon specifies for a stop codon
Lesser curvature of the antrum of the stomach
Nonsense
Operon
Voltage - gated sodium channel

6. Which benzodiazepine has the shortest half - life?
TLC - FRC - and RV have to be calculated. (Remember - any volume that has RV as a component has be calculated.)
The dose of glipizide must be decreased in hepatic dysfunction. Glyburide's dose must be decreased in renal dysfunction.
3 months of symptoms in 2 consecutive years
Triazolam

7. The probability that a person with a negative test result is truly disease free refers to what value?
Negative predictive value
Leiomyoma
Isoleucine - threonine - tryptophan - tyrosine - and phenylalanine
L4 to S3 (L2 to L4 - thigh; L4 to S3 - leg)

8. What X- linked recessive immune disorder is characterized by recurrent infections - severe thrombocytopenia - and eczema?
Wiskott - Aldrich syndrome
Major
Bronchogenic carcinoma
Coma - convulsions - and cardiotoxicity

9. What hormone is characterized by the following renal effects? - Calcium reabsorption - phosphate excretion
Glioblastoma multiforme
Carcinoid tumor
PTH
Major

10. Are the following major or minor Jones criteria of rheumatic fever? - Arthralgias
31 pairs
Alzheimer's (dementia of Alzheimer's type - DAT). (Remember - Alzheimer's constitutes 65% of dementias seen in patients 65 years old.)
At the beginning of splay is when the renal threshold for glucose occurs and the excess begins to spill over into the urine.
Minor

11. What ocular muscle x Adducts the eyeball and is involved in horizontal conjugate gaze?
LCO - an index of lung surface area and membrane thickness - is decreased in fibrosis because of increased membrane thickness and decreased in emphysema because of increased surface area without increase in capillary recruitment; in exercise there is
Bronchoconstriction is associated with parasympathetic stimulation (ACh) - and catecholamine stimulation is associated with bronchodilation (why epinephrine is used in emergency treatment of bronchial asthma.)
Medial rectus (CN III) (LR6 SO4)3
Senile plaques - neurofibrillary tangles - and granulovascular changes in neurons

12. Name the antidote - Carbon monoxide (CO)
Oxygen
Inhaled anesthetics with low lipid solubility have low potency (directly related) - so they have rapid induction and rapid recovery; vice versa for drugs with high lipid solubility.
RBCs
IgA nephropathy

13. What is the order of fuel use in a prolonged fast?
SLE; ANA - anti - dsDNA and anti - Sm (anti - Smith)
No - but it does interfere with performing complex tasks and decreases attention to detail. (Be careful post call!)
1. Glucose from liver glycogen 2. Glucose from gluconeogenesis 3. Body protein 4. Body fat
Gonorrhea

14. What pancreatic islet cell tumor is associated with hypoglycemia - sweating - hunger - confusion - and increased C- peptide levels?
Insulinoma
Both
CLL (B- cell origin)
IF and GTP (eIF for eukaryotes)

15. What Brodmann area is associated with x Primary visual cortex?
Ureaplasma urealyticum
Toxoplasma gondii
Posterior hypothalamic zones; lesions here result in poikilothermy (environmental control of one's body temperature).
Area 17

16. Fact without feeling (la belle indiff
Prostatic carcinoma
Graves disease
Isolation of affect
t the end of the PCT 25% of Na+ - Cl - - K+ is left

17. What disease has multiple schwannomas - caf
Streptomycin
Gain of hypertonic fluid (mannitol or hypertonic saline)
Squamous cell carcinoma of the lung
Neurofibromatosis I (chromosome 22q is with neurofibromatosis II and no Lisch nodules)

18. What nucleus supplies the preganglionic parasympathetic fibers to the ciliary ganglion?
Osteoma
Edinger - Westphal nucleus (via CN III)
Aldolase B deficiencies are treated by eliminating fructose from the diet.
SHIP: Shifting of the aorta - Hypertrophy of the right ventricle - Interventricular septal defect - Pulmonary stenosis

19. What complex is needed for propionyl CoA carboxylase?
TXA2
Biotin - ATP - and CO2
IL-2. T cells express IL-2 receptors on their surface to induce self - expression.
Familial polyposis coli

20. What subtype of schizophrenia is characterized by x Delusions of persecution and/or grandeur - auditory hallucinations - late onset - and the best prognosis?
Terminal collecting duct has the highest concentration and Bowman's capsule has the lowest concentration of inulin.
Paranoid schizophrenia
N- Acetylcysteine
Middle meningeal artery

21. What drug - if given during pregnancy - would cause the uterus to exhibit signs of progesterone withdrawal and induce an abortion?
DiGeorge syndrome - Which is due to a failure of the third and fourth pharyngeal pouch development. Remember - B cell deficiencies are associated with extracellular infection. T cell deficiencies are associated with intracellular infections
Preoperational (2-6 years)
P wave
RU 486

22. What five things are checked in the APGAR test?
Anterior nuclear group (Papez circuit of the limbic system)
1. Skin color 2. Heart rate 3. Reflexes 4. Muscle tone 5. Respiratory rate APGAR - Appearance - Pulse - Grimace - Activity - Respiration
1. Low pressure in the afferent renal arteriole 2. Low sodium sensed by the macula densa 3. Increased Beta-1- sympathetic stimulation of the JG cells
Tetracycline

23. Name the antidote - Isoniazid
Quinolones
Alveoli; they are part of the respiratory portion.
1. Caput medusae 2. Esophageal varices 3. Ascites 4. Splenomegaly 5. Hemorrhoids
Pyridoxine

24. What prostaglandin is associated with maintaining patency of the ductus arteriosus?
Wegener granulomatosis
PGE (along with low oxygen tension)
Osteosarcoma
Cortisol

25. What are the five branches of the median cord of the brachial plexus?
Four Ms and a U 1. Median 2. Medial antebrachial 3. Medial pectoral 4. Medial brachial cutaneus 5. Ulnar
Primitive atrium
Cones (C for color and cones)
Parasympathetics (parasympathetics point - sympathetics shoot)

26. Name the phase of the ventricular muscle action potential based on the following information: x Fast channels open - then quickly close - and sodium influx results in depolarization
Cestodes
Schizotypal
rRNA
Phase 0

27. What pathophysiologic disorder is characterized by the following changes in cortisol and ACTH? - Cortisol increased - ACTH decreased
Primary hypercortisolism
Increased leukocyte alkaline phosphatase (LAP)
Ventricular fibrillation (V fib)
IgA

28. Use of an outlet for emotions (stuff flows downhill).
DiGeorge syndrome
Utricle and saccule
Missense
Displacement

29. What phase of the cell cycle are the following antineoplastic agents specific for? - 6- Thioguanine
X- linked recessive
S phase
Endometriosis
Amyloidosis

30. What type of circuit is described when the total resistance is always greater than the sums of the individual resistors?
Series circuit
Anterior compartment (it's the blood supply to the posterior compartment)
ACh
The stomach

31. With a decrease in arterial diastolic pressure - what happens to x Heart rate?
DNA polymerase -?
16S subunit
Decreases
Constriction of afferent arteriole

32. How does ventricular repolarization take place - base to apex or vice versa?
1. Liver 2. Kidney 3. Pituitary gland (via 5'- deiodinase enzyme)
Major
Repolarization is from base to apex and from epicardium to endocardium.
hCG can be detected in the blood by day 8 and in the urine by day 10.

33. What law states that an enlarged - palpable gallbladder is more likely due to cancer than stone obstruction?

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34. What are the four functions of saliva?
Staphylococcus aureus
Positive correlation
I- cell disease is a result of a genetic defect affecting the phosphorylation of mannose residues.
1. Provide antibacterial action 2. Lubricate 3. Begin CHO digestion 4. Begin fat digestion

35. What subset of adenocarcinoma arises from the terminal bronchioles and/or alveolar walls?
Neomycin
prior to birthThe foramen ovale closes just...
Bronchioloalveolar carcinoma
Cocaine

36. What is the DOC for hyperprolactinemia?
Pergolide
Estrogen
1. CNS 2. Renal tubules 3. Beta Islet cells of the pancreas 4. RBCs 5. GI mucosa
presence of PMNs

37. A clear - hypertonic solution with higher concentrations of K + and HCO3- - than the serum.
Uroporphyrinogen III cosynthase
The carotid sinus reflex
CSF
TAT (Thematic apperception test)

38. Name the macrophage based on its location: x Connective tissue macrophages
The sandfly
Histiocytes
LTB4
Arthroconidia with hyphae

39. Name the antidote - Organophosphates
9 kcal/g from fat metabolism; 4 kcal/g from both CHO and protein metabolism
Selegiline
Anti - HAV IgG Abs are associated with immunization or a prior infection. Anti - HAV IgM is associated with acute or recent infection.
Atropine - 2- PAM (pralidoxime)

40. What rare disorder presents as a large - hard - irregular thyroid gland due to fibrous proliferation of connective tissue in the thyroid gland and extends to adjacent structures?
Splenic flexure
CN IX and X
Riedel thyroiditis
Superior

41. What nematode is known as pinworms? What is the treatment?
Enterobius vermicularis; the treatment is albendazole.
Atropine - 2- PAM (pralidoxime)
Amyl nitrate - sodium nitrate - or sodium thiosulfate
Glycogen phosphorylase

42. What enzyme catalyzes the rate - limiting step in pyrimidine synthesis?
Aspartate transcarbamylase
Disulfiram
Kawasaki disease
Plasmodium malariae; the others are tertian.

43. Neurofibrillary tangles
The vagina
Eisenmenger syndrome - which can also occur with any left - to - right shunt
Chromaffin cells (adrenal medulla)
Alzheimer disease

44. Acts as the vertebral body of C1 allowing lateral rotation of the head. The first cervical vertebra has no vertebral body.
Osteosarcoma
The odontoid process of C2
In the peroxisome until it is 10 carbons long; the rest is completed in the mitochondria.
M3 (promyelocytic leukemia)

45. What is the relationship between ventilation and PCO2 levels?
HIV and poxvirus
B lymphocyte
CN IX - X - and XI; sigmoid sinus
They are inversely related. If ventilation increases - there will be a decrease in PCO2 levels and vice versa.

46. Does the heart rate determine the diastolic or systolic interval?
Heart rate determines the diastolic interval - and contractility determines the systolic interval.
1. Increase compliance 2. Decrease surface tension 3. Decrease probability of pulmonary edema formation
Pseudomembranous exudates
Procainamide

47. What is the only sphingolipid that contains choline and PO4?
Selection bias
Sphingomyelin (lecithin also - but it is not a sphingolipid)
Lysosomal a -1 - 4- glucosidase
Heart rate determines the diastolic interval - and contractility determines the systolic interval.

48. Outburst to cover up true feelings (emotion is covered - not redirected).
von Gierke's disease
Acting out
The increased H+ moves intracellularly and is buffered by K+ leaving the cells - resulting in intracellular depletion and serum excess. (Intracellular hypokalemia is the reason you supplement potassium in diabetic ketoacidosis - even though the serum
Kayser - Fleischer ring

49. What type of Plasmodium affects x RBCs of all ages?
Enterobius vermicularis; the treatment is albendazole.
Plasmodium falciparum
Palatoglossus muscle is innervated by CN X; all other tongue muscles are innervated by CN XII.
Latency stage (6-12 years)

50. What is the most common form of inherited dwarfism?
Third M PITS for pharyngeal pouch derivatives
1. H2O2 2. Superoxide 3. Hydroxyl radical 4. Myeloperoxidase 5. Hypochlorous acid
Achondroplasia
Plummer - Vinson syndrome