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USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. In what disease do you see horseshoe kidneys - rockerbottom feet - low - set ears - micrognathia - and mental retardation?
Adenocarcinoma (because of Barrett esophagus)
Edward syndrome (trisomy 18)
The fastigial nucleus
Streptococcus agalactiae and Escherichia coli

2. What type of skin carcinoma occurring on sun - exposed sites has a low level of metastasis?
Squamous cell carcinoma
Trichomonas vaginalis (treat with metronidazole)
Loose association
Chronic alcoholic

3. What phase of Food and Drug Administration approval tests x The efficacy and occurrence of side effects in large group of patient volunteers?
Phase III. It is considered the definitive test.
HPV
Neisseria gonorrhea (history of STD in patient with monoarticular infectious arthritis: think gonococcus)
The larger the volume of distribution - the lower the plasma concentration of a drug.

4. What cell type in the bone is responsible for bone deposition?
Schistosoma haematobium
Middle meningeal artery
RNA polymerase I
Osteoblast (Remember - blasts make - clasts take)

5. What disorder leads to IgG autoantibodies to the TSH receptor?
Graves disease
Mitosis
Potter facies
Labile

6. What is the term for cytoplasmic remnants of RNA in RBCs - seen in lead poisoning?
Tip of the loop of Henle (1200 mOsm/L)
Prevalence increases. (Incidence does not change.)
Basophilic stippling
Parasympathetics (parasympathetics point - sympathetics shoot)

7. What B- cell neoplasm is seen in males with massive splenomegaly - produces dry tap on bone marrow aspirations - and stains positive for tartrate - resistant acid phosphatase (TRAP)?
ASA (salicylate)
Hairy cell leukemia
45XO
Oncotic pressure increases because of the removal of water.

8. What organelles make ATP - have their own dsDNA - and can synthesize protein?
eEF-2 is the site where Pseudomonas and Diphtheria toxins work.
1. Cough 2. Coryza 3. Conjunctivitis
Mitochondria
Lesser curvature of the antrum of the stomach

9. To what viral family does the polio virus belong?
The muscle's ATPase activity
Thiabendazole
Picornaviridae
Selegiline

10. Where are the tonsillar tissues?

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11. Blue sclera
Ampulla of the fallopian tube
Measles (rubeola)
Osteogenesis imperfecta
Staphylococcus aureus

12. What form of anemia is diagnosed with sucrose lysis test and Ham test?
Antithyroglobulin and antimicrosomal Abs
Paroxysmal nocturnal hemoglobinuria
Increase in erythropoietin and increase in 2 - 3- BPG - also called 2 - 3- diphosphoglycerate (2 - 3- P2Gri) (increase in glycolysis)
Masochism

13. What muscle or muscles are innervated by the following nerves? - Suprascapular nerve
Supraspinatus and infraspinatus
Streptococcus pneumoniae
Obese patients
JC virus

14. What artery travels with the following veins? - Middle cardiac vein
Posterior interventricular artery
Diazepam is longest acting and midazolam is shortest acting.
Dihydropteroate synthetase
Vitamin D

15. What percent of sexual abuse cases are committed by family members?
Chromosome 19
Anatomical dead space - which ends at the level of the terminal bronchioles.
Translation
50%. The uncles and older siblings are the most likely perpetrators - although stepfathers also have a high rate.

16. Regarding neuroleptics - What is the relationship between potency and anticholinergic side effects?
The muscle's ATPase activity
Inversely proportional: the higher the potency - the lower the anticholinergic side effects.
Nominal scale (categorical - e.g. - male or female)
Yes

17. Which IL increases IgA synthesis?
Primary hyperparathyroidism
Pentoxifylline
At birth (reflex)
IL-5. It also stimulates eosinophil proliferation.

18. Via what pathway is glycolysis increased after phagocytosis?
Takayasu arteritis (medium - size to large vessels)
HMP shunt
Escherichia coli
RSV

19. What neuroleptic agent causes retinal deposits - hypotension - and torsades de pointes?
Sorbitol (resulting in cataracts)
Thioridazine
Pancreas and colon
Primary polydipsia; patients with diabetes insipidus will continue to produce large volumes of dilute urine.

20. What protein of the HIV virus does ELISA detect to determine whether a patient is HIV positive?
Tamoxifen
Western blot
Gain of hypotonic fluid (water intoxication or hypotonic saline)
P24

21. What condition results in the following CSF results? - Opening pressure 250 mm H2O; WBCs 250 (90% lymphocytes); glucose 35; protein 100
Malpighian layer (made up of the stratum basale and stratum spinosum)
Mees lines
Linoleic acid and linolenic acid
TB meningitis

22. What muscle or muscles are innervated by the following nerves? - Long thoracic nerve
Serratus anterior
Antidigoxin Fab fragments
Staphylococcus aureus
Mitosis

23. What prion - associated CNS pathology produces rapidly progressive dementia with myoclonus - involuntary movements - and death within 6 to 12 months?
Creutzfeldt - Jakob disease
Brief psychotic disorder. (In schizophreniform disorder the symptoms last longer than 6 months.)
RSV
Ventricular contraction Atrial - Contraction - Venous

24. What Ab is an indication of low transmissibility for hepatitis?
M
HBeAb
Ethyl alcohol
Agents that decrease ACh function reduce tremors and rigidity - not bradykinesias.

25. What right - to - left shunt occurs when only one vessel receives blood from both the right and left ventricles?
Calcium influx secondary to slow channel opening
Persistent truncus arteriosus
Chromophobe adenoma
Action potential

26. Which diuretic is used as an adrenal steroid antagonist?
Listeria monocytogenes
Spironolactone
Air flows into the respiratory system.
Hepatitis B

27. What classical conditioning therapy or modification is described as x Pairing noxious stimuli to an inappropriate behavior?
Afterload
Aversive conditioning
Naloxone or naltrexone
They are inversely proportional to each other; as pulse pressure increases - compliance decreases.

28. What form of continuous DNA - used in cloning - has no introns or regulatory elements?
Moving objects - along with large bright objects with curves and complex designs.
In the first 3 months
>15 mm
cDNA - when it is made from mRNA

29. What AA undergoes N- glycosylation?
Capillary flow and pressure increase with arteriolar dilation and decrease with arteriolar constriction.
Histoplasma capsulatum
Asparagine
Nicotinic acid - because its side effects include hyperuricemia and exacerbation of ulcers.

30. With a decrease in arterial diastolic pressure - what happens to x TPR?
premature ejaculation
VLDL
Decreases
1. Sleep paralysis 2. Hypnagogic hallucinations (while falling asleep) 3. Sleep attacks with excessive daytime sleepiness 4. Cataplexy (pathognomonic) Narcolepsy is a disorder of REM sleep - with REM occurring within 10 minutes of sleep.

31. Describe the organism based on the following information: x Beta - Hemolytic Streptococcus; positive cAMP test; hydrolyzes hippurate
Diphyllobothrium latum
Constrictor pupillae and ciliary muscles
Streptococcus agalactiae
Squamous cell carcinoma (skin - lung) and angiosarcoma of the liver

32. What segments of the lumbosacral plexus form the following nerves? - Femoral nerve
Hirschsprung's disease (colonic gangliosus)
Repression
Two major or one major and two minor
L2 to L4 (L2 to L4 - thigh; L4 to S3 - leg)

33. When does the primitive gut herniate out of the embryo? When does it go back into the embryo?
6 weeks 10 weeks
Streptococcus pneumoniae
None. Denaturation of dsDNA breaks hydrogen bonds - not covalent bonds.
Varicella

34. Name the eukaryotic DNA polymerase based on the following information: x Synthesizes the leading strand during replication
Epstein - cardiac anomaly of the tricuspid valve
Ataxia - telangiectasia
DNA polymerase - d
Axis II

35. Name the type of regeneration (i.e. - labile - stable - or permanent) based on the following examples - Kidney
Sorbitol (resulting in cataracts)
Voyeurism
BPH. Although an argument can be made for prostatic cancer (you should expect a much higher PSA result) - these are buzzwords for BPH. Prostatic cancer is usually silent until late in the disease - when obstructive symptoms begin to occur.
Stable

36. What sweat gland type is associated with odor production and hair follicles and is found in the axilla?
In the JG cells of the kidney
Separation anxiety
APocrinE glands (APES is my memory aid) Axilla - Areola - and Anus all begin with A. APES are hairy (associated with hair follicles). They smell (odor production) - and if confronted by an APE - your Adrenergic nervous system would be firing (innerva
Physiologic antagonism

37. What organ is responsible for the elimination of excess nitrogen from the body?
C3 deficiency
Aedes mosquito
The kidneys excrete the excess nitrogen from the body as urea in the urine.
Streptococcus viridans

38. What is the term to describe the 5'-3' sequence of one strand being the same as the opposite 5'-3' strand?
Primary intention
Spermatogonia (type A)
Palindrome
Krukenberg tumor

39. What TCAD causes sudden cardiac death in children?
ydroxyproline
Desipramine
Phase 1
Luteal phase

40. What type II hypersensitivity disorder is defined as x Autoantibodies directed against platelet integrin?
Eight pairs through seven cervical vertebrae. Totaling 31 pairs of spinal nerves.
Phototherapy
Streptolysin O
Autoimmune thrombocytopenia purpura

41. What is the term to describe the increased rate of secretion of adrenal androgens at the onset of puberty?
Leiomyoma (fibroids)
Adrenarche
Metaproterenol and albuterol
Variable ratio If it is based on time - it is an interval - and if it is based on the number of responses - it is a ratio.

42. To What does aldose reductase convert galactose?
Galactitol
No - it is never acceptable to lie.
IgG
Xanthine oxidase

43. What muscle is most superior in the orbit?
Splitting of the first heart sound occurs during inspiration because of the increased output of the right ventricle - delaying the closure of the pulmonic valve.
Levator palpebrae superioris
Ventricular contraction Atrial - Contraction - Venous
Third week

44. Is a nicotinic receptor agonist.
1. Clavulanic acid 2. Sulbactam 3. Tazobactam
Sulfonamides
Succinylcholine
Mesocortical area

45. A 25-year - old black woman presents with nonproductive cough - shortness of breath - fatigue - and malaise; she has bilateral hilar lymphadenopathy on chest radiography and elevated ACE levels. What do you diagnose?
Transient protein C deficiency - because of its relatively short half - life - may result if warfarin is instituted alone.
Fat necrosis
Osteitis fibrosa cystica (von Recklinghausen disease)
Sarcoidosis

46. Name these narcissistic defense mechanisms: x Person takes his or her own feelings - beliefs - wishes - and so on and thinks they are someone else's. (e.g. - a cheating man thinks his wife is unfaithful)
Chromosome 9 - 22 (Philadelphia chromosome)
Projection
ASD
Tibial nerve

47. Name the lung measurement based on the following descriptions: x Amount of air in the lungs after maximal inspiration
Total lung capacity (TLC)
Dihydrofolate reductase
Reinforcement
transcription

48. What renal disease in diabetic patients is seen as a halo of capillaries around the mesangial nodules?
Kimmelstiel - Wilson disease
Argyll Robertson pupils
Liver - kidneys - and pituitary gland via 5' deiodinase enzyme
Suppression

49. What is the fastest - conducting fiber of the heart? Slowest conduction fiber in the heart?
Lipoid nephrosis
Labile
Purkinje cell is the fastest - and the AV node is the slowest.
Chief cell adenoma (80%)

50. What malignant tumor of the skin is associated with Birbeck granules?
Infliximab
Histiocytosis X
Nominal scale (categorical - e.g. - male or female)
Metastatic