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USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. In regard to motor development during infancy - choose the motor response that happens first - Release or grasp
Bacterial meningitis
Increases
Catatonic schizophrenia
Grasp proceeds release

2. What nerve supplies general sensation to the anterior two - thirds of the tongue?
Spinal trigeminal nucleus
Middle meningeal artery
Isocitrate dehydrogenase - a - ketoglutarate dehydrogenase - and malate dehydrogenase
Lingual nerve of CN V3

3. What type of hypersensitivity is a T cell - mediated response to Ags that are not activated by Ab or complement?
Succinate dehydrogenase
Escherichia coli
Increased REM sleep - decreased REM latency - and decreased stage 4 sleep - leading to early morning awakening
Type IV hypersensitivity reaction (delayed type because of the 48-96 hour latency)

4. What generate anterograde transport of information in a neuron?
Kinesins. Dynein generates retrograde transportation of information.
HBsAg as its envelope
The enzyme lysyl oxidase requires Cu2+and O2 to function properly.
In the peroxisome until it is 10 carbons long; the rest is completed in the mitochondria.

5. What personality disorder affects 75% of the prison population?
Increased CO2 - H+ - temperature - and 2 - 3- BPG levels all shift the curve to the right - thereby making the O2 easier to remove (decreased affinity) from the Hgb molecule.
Insulin
Prophase of meiosis I (between 12th and 22nd week in utero)
Antisocial personality

6. What part of the heart forms x Apex?
Tip of the left ventricle
Prolactinoma
Dyslexia
IL-2. T cells express IL-2 receptors on their surface to induce self - expression.

7. Name the RNA subtype based on the following: x RNA molecules with enzymatic activity
Ribozymes
Normal values
Parkinson's disease
Dominant parietal lobe (Gerstmann's syndrome)

8. What are known as jumping genes?
Iatrogenesis
Ciliary ganglion
The number of Ags that the Ab can bind
Transposons

9. What negative sense RNA virus is associated with parotitis - pancreatitis - and orchitis?
C3 deficiency
Mumps
C wave
Kidney

10. What type of metal poisoning causes mental retardation - somnolence - convulsions - and encephalopathy?
Mebendazole
Menstruation
Thyroid hormones increase serum glucose levels by increasing the absorption of glucose from the small intestine.
Lead

11. What type of fiber or fibers are carried in (answer motor - sensory - or both) x Spinal nerve?
Both
Schizoid
To provide attachment between contiguous cells and to maintain a semipermeable barrier
Herpesvirus

12. What antiviral agent is used in the treatment of drug - induced Parkinson's disease?
Affinity
Amantadine
Integument (skin and its derivatives)
Yersinia pestis

13. Name the antidote - Warfarin
Vitamin K
Ceramide
90% as HCO3- - 5% as carbamino compounds - and 5% as dissolved CO2
Ipsilateral flaccid paralysis

14. What encephalopathy causes ocular palsies - confusion - and gait abnormalities related to a lesion in the mammillary bodies and/or the dorsomedial nuclei of the thalamus?

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15. What condition results from a deficiency in the enzyme hexosaminidase A?
Zero correlation
Tay- Sachs disease
Thymine (B1)
Neisseria meningitides

16. Where is most of the airway resistance in the respiratory system?
Osteoporosis
Hyperplasia
In the first and second bronchi
Phase 4

17. What hormone's release is strongly associated with stage 4 sleep?
0157:H7
Klebsiella pneumoniae
Nodular melanoma
GH. The largest output of GH in a 24- hour period is during stage 4 sleep.

18. What reflex enables the eyes to remain focused on a target while the head is turning?
Arnold - Chiari malformation type 2
Somatomedins (IGF-1)
Production of oxygen free radicals
The vestibulo - ocular reflex

19. What reflex increases TPR in an attempt to maintain BP during a hemorrhage?
The carotid sinus reflex
Rapid cycling bipolar disorder
GH
Tibial nerve

20. Which tetracycline is used to treat prostatitis because it concentrates strongly in prostatic fluid?
Decreases Remember - the carotid sinus reflex attempts to compensate by increasing both TPR and heart rate.
Non - Hodgkin lymphoma
Vibrio vulnificus
Doxycycline

21. What is the term for days 1 to 7 of the female cycle?
High average
Clofazimine
Somatization disorder
Menses

22. Name the compartment of the mediastinum associated with the following thoracic structures: SVC
Selection bias
Physiologic antagonism
Superior and middle
Atrial filling (venous filling) Atrial - Contraction - Venous

23. Name the phase of the ventricular muscle action potential based on the following information: x Slow channels open - allowing calcium influx; voltage - gated potassium channels closed; potassium efflux through ungated channels; plateau stage
Clearance
Phase 2
A Ghon focus is a TB tubercle - whereas a Ghon complex is a focus with hilar lymph node involvement.
Hepatitis E

24. What rate removes any difference between two populations - based on a variable - to makes groups equal?
Rabies
Ego syntonic
B- cell Ag receptors
Standardized rate

25. Name the compartment of the mediastinum associated with the following thoracic structures: Aortic arch
Prostatic carcinoma
Coagulative
Superior
Eaton - Lambert syndrome

26. What disease is described by bilateral flaccid weakness of the upper limbs (LMN) and bilateral spastic weakness of the lower limbs (UMN) beginning at the cervical level of the spinal cord and progressing up or down the cord?

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27. Name the thalamic nucleus based on its input and output - Input from the mammillary bodies via the mammillothalamic tract and the cingulated gyrus; output to the cingulated gyrus via the anterior limb of the internal capsule
Anterior nuclear group (Papez circuit of the limbic system)
Since CO2 is 24 times as soluble as O2 - the rate at which CO2 is brought to the membrane determines its rate of exchange - making it perfusion - limited a gas. For O2 the more time it is in contact with the membrane - the more likely it will diffuse
Cardiac output
Breast cancer

28. What nematode is known as hookworms? What is the treatment?
Necator americanus is treated with mebendazole and iron therapy.
The basilar artery is formed at the pontomedullary junction.
Thymine
Pseudohyphae

29. Name the insulin preparation based on the peak effect and duration of action - Peak - 0.3 to 2 hours; duration - 3 to 4 hours
Streptococcus agalactiae
Lispro insulin
Hepatocellular carcinoma
Occulta All except occulta cause elevated - fetoprotein levels.

30. Name the type of hypersensitivity reaction based on the following properties - Circulating Ab - Ag immune complexes deposited in the tissue result in neutrophil attraction and the release of lysosomal enzymes.
Type III hypersensitivity (immune complex)
1. Flow independent of BP 2. Flow proportional to local metabolism 3. Flow independent of nervous reflexes
Hgb F
Hepatocellular carcinoma

31. What type of membrane channel opens in response to depolarization?
Howell - Jolly bodies
Voltage - gated channel
Transient ischemic attack
Atrial filling (venous filling) Atrial - Contraction - Venous

32. What peripheral chemoreceptor receives the most blood per gram of weight in the body?
Hypothyroidism. (TSH levels must be monitored.)
The carotid body - which monitors arterial blood directly
Midazolam
The secretory phase is progesterone - dependent and 14 days long - whereas the length of the proliferative phase varies

33. What stage of male development is characterized by the following LH and testosterone levels? - Decreased testosterone production is accompanied by an increase in LH production.
Aged adult
The tsetse fly
Neurologic symptoms Renal failure Thrombocytopenia Fever Microangiopathic hemolytic anemia (Don't forget it. When I was an intern - my senior resident asked me this question more times than I would like to remember.)
Microglia. All others are neuroectodermal derivatives.

34. Will a patient with a unilateral lesion in the cerebellum fall toward or away from the affected side?
Giant cell tumor of the bone
Patients with unilateral cerebellar lesions fall toward the side of the lesion.
Myasthenia gravis
The fasciculus gracilis (Graceful) - which lies closest to the midline of the spinal cord.

35. What three structures increase the surface area of the GI tract?
Osteopetrosis (Albers - Sch
t the end of the PCT 25% of Na+ - Cl - - K+ is left
1. Plicae circularis (3 times) 2. Villi (30 times) 3. Microvilli (600 times)
Alternative hypothesis (What is left after the null has been defined)

36. What hormone is necessary for normal GH secretion?
Normal thyroid hormones levels in the plasma are necessary for proper secretion of GH. Hypothyroid patients have decreased GH secretions.
It is produced by the preload on the muscle prior to contraction.
Inhibin - m
Squamous cell carcinoma

37. What bones make up the acetabulum?
IgD; IgM is also correct.
Sarcoidosis
urease positive
Pubis - ilium - and ischium

38. Which muscarinic receptor uses a decrease in adenyl cyclase as its second messenger?
Ceramide
Macula densa
Area 8
M 2

39. There is no hormonal control to the...
Pergolide
Proencephalon diencephalon derivative
Candida albicans
TCA cycle.

40. Name the product or products of arachidonic acid: x Chemotactic for neutrophils
Pneumocystis carinii
LTB4
Rho (D) immune globulin (RhoGAM) - an anti - RhD IgG antibody - prevents generation of RhD- specific memory B cells in the mother.
Syphilitic

41. What disorder is due to a deficiency in the enzyme phenylalanine hydroxylase?
Alcohol abuse
Stage 2
Rho (D) immune globulin (RhoGAM) - an anti - RhD IgG antibody - prevents generation of RhD- specific memory B cells in the mother.
PKU

42. What is the amount in liters and percent body weight for the following compartments? - Interstitial fluid
Nitroblue tetrazolium reduction test (NBT). It is negative in patients with CGD because there is no production of oxygen radicals.
The myotatic reflex is responsible for the tension present in all resting muscle.
Escherichia coli
9.3 L - 15% of body weight

43. After fertilization - what cells of the corpus luteum x Secrete estrogen?
Theca cells secrete estrogen. After fertilization the theca cells form from the theca interna.
Osteosarcoma
Flocculonodular lobe (one of my favorite words in all of medicine!)
Rigors - leukopenia - decrease in blood pressure - and increase in temperature

44. What is the name of the major chemotactic agent released from x The blood serum? (Hint: it is a complement factor.)
Bactericidal
Ampulla
Spironolactone
C5a

45. What area of the hypothalamus is responsible for recognizing an increase in body temperature and mediates the response to dissipate heat?
Posterior
Mode
CN I
Anterior hypothalamic zone; lesions here result in hyperthermia.

46. What drug causes a sixfold increase in schizophrenia - can impair motor activity - and can cause lung problems?
Marijuana
Enterohepatic cycling
Absolutely not. Diabetics who are given a Beta- blocker for an acute chest syndrome have significantly better outcomes than those who do not.
Hypothyroidism. (TSH levels must be monitored.)

47. Name the associated chromosomal translocation - CML
Gerstmann's syndrome; spoken language is usually understood.
Libman - Sacks endocarditis
Chromosome 9 - 22 (Philadelphia chromosome)
Penicillin G (benzylpenicillin)

48. What part of the heart forms x Left border?
Hirschsprung's disease (colonic gangliosus)
Left ventricle and auricle of left atrium
Libman - Sacks endocarditis
VLDLs

49. At what stage of cognitive development (according to Piaget) do children x Have abstract thinking?
Methylation of bacterial DNA
Prodrugs
Janeway lesions
Formal operations (> 12 years)

50. What presynaptic receptor does NE use to terminate further neurotransmitter release?
Mesangial macrophages
1. VSD 2. ASD 3. PDA
Subarachnoid hematoma
alpha2- Receptors