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Test your basic knowledge |
USMLE Step 1 Prep
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The separation of 46 homologous chromosomes without splitting of the centromeres occurs During what phase of meiosis?
prognostic predictors
G-6- PD deficiency; pyruvate kinase deficiency is second.
Adaptive branch. The adaptive branch of the immune system has a slow initiation with rapid responses thereafter.
Meiosis I; disjunction with centromere splitting occurs during meiosis II.
2. What type of questions should you begin with when a patient seeks your medical opinion?
It is best to begin with open - ended questions - allowing patients to describe in their own words What troubles them. You can then move to closed - ended questions when narrowing the diagnosis.
Polyarteritis nodosa
Intussusception
HBcAb IgM - HBV- DNA - HBeAg - HBsAg
3. What class of pharmaceuticals are inactive until they are metabolized to their active products?
Bainbridge reflex
Prodrugs
Secondary hypocortisolism (pituitary)
Succinyl CoA
4. Name the cancer associated with the following oncogenes. (Some may have more than one answer) x et
Hepatocytes lack the enzyme succinyl CoA acetoacetyl CoA transferase (thiophorase).
Tamoxifen
Factors II - VII - IX - and X and proteins C and S.
MEN II and III syndromes
5. What happens to dopamine levels when we awaken?
Dopamine levels rise with waking; dopamine is associated with wakefulness.
Insulinoma
Candida
Transtentorial (uncal)
6. What tract carries unconscious proprioceptive information from the Golgi tendon organs and muscle spindles to the cerebellum - helping monitor and modulate muscle movements?
Suprachiasmatic nucleus
Verbigeration
Lower extremity and lower trunk information travels in the dorsal spinocerebellar tract. The upper trunk and extremity information travels in the cuneocerebellar tract. (Cuneocerebellar and fasciculus cuneatus both apply to upper extremities.)
Primitive ventricle
7. Name the pattern of genetic transmission characterized thus: both M and F affected; no M- to - M transmission; affected M passes trait to all daughters - every generation; affected F passes trait to both sons and daughters; a single mutant allele can
Thoracic splanchnic fibers
Introjection (a sports fan is a good example)
X- linked dominant
Succinate dehydrogenase
8. Which anticonvulsant used in the treatment of bipolar disorder is refractory to lithium?
Carbamazepine
Mitosis
Cytochrome c
Roth spots - and they are seen in bacterial endocarditis.
9. Do the following structures pick up stain from hematoxylin or eosin? - Bacteria
Hematoxylin
HTLV-1
Short - chain fatty acids
The right and left pulmonary arteries - the only arteries that carry deoxygenated blood
10. Are the following major or minor Jones criteria of rheumatic fever? - Pericarditis
Brain abscess
Major
Temporal lobes
Paroxysmal nocturnal hemoglobinuria
11. What component of the ETC is inhibited by the following? - Oligomycin
Birth defects - low birth weight (< 1500 g) with neonatal respiratory distress syndrome (NRDS) - and SIDS
Fo/F1 complex
RBCs
Caput medusa - internal hemorrhoids - esophageal varices - retroperitoneal varices - and splenomegaly
12. What specifies how accurately the sample values and the true values of the population lie within a given range?
Confidence interval. It is a way of admitting estimation for the population.
positive correlation
Diphenhydramine
Vaginismus; it is the female counterpart of premature ejaculation.
13. Are bactericidal.
LTB4
Tetracyclines
7 to 14 days
Autosomal dominant
14. What female genital tract disorder is characterized by obesity - hirsutism - infertility - amenorrhea - elevated LH and testosterone levels - and low FSH levels?
Acute CO poisoning
Norm reference (i.e. - 75% of the students in the class will pass)
Homocysteine methyl transferase
Polycystic ovary disease (Stein - Leventhal syndrome)
15. From what pharyngeal pouch is the following structure derived? - Superior parathyroid gland and ultimobranchial body of the thyroid
IgG4
Fourth M PITS for pharyngeal pouch derivatives
Nodular melanoma
Superior Oblique (CN IV) (LR6 SO4)3
16. From which two substances are phospholipids made?
Diacylglycerols and phosphatidic acid
t the end of the PCT 25% of Na+ - Cl - - K+ is left
Lithium
Being a female physician increases the risk of suicide nearly four times the general population.
17. What has proved to be the best way to extinguish enuresis?
Water soluble
H 1
Plasmin
Bell pad
18. What is the term for gastric ulcers associated with severely burned or traumatic patients?
Parasympathetic
Curling ulcers (think curling iron = burn)
Middle cerebral artery
Internal abdominal oblique
19. What is the only factor of enzyme kinetics that the enzyme affects?
Ea (activation energy)
50% - with 50% of them having the child
Priapism
Shigella
20. What embryonic structure forms the following adult structures? - Collecting ducts - calyces - renal pelvis - and ureter
B cells; macrophages and dendritic cells are nonspecific.
pH of 2 and 9
Mesonephric duct (ureteric bud)
Hepatitis A
21. In which syndrome does a person present with intentionally produced physical ailments with the intent to assume the sick role?
Truncus arteriosus
Area 4
Heart disease
M
22. What is the most common one? - Type of melanoma
Superficial spreading melanoma
Poliomyelitis; it is a bilateral LMN lesion.
Testicular tumors
Ulnar to radial progression
23. What part of the inner ear contains the gravity receptors for changes in the position of the head?
Saccule and utricle
Poxvirus replicates its DNA in the cytoplasm.
Blastoconidia
1. Diarrhea 2. Dermatitis 3. Dementia 4. Death
24. What type of scheduled reinforcement states that after a desired response - the reinforcement is given x Varying in time?
Because RPF is markedly decreased - while GFR is only minimally diminished; this results in an increase in FF (remember FF = GFR/RPF).
Subarachnoid hemorrhage
Somatization disorder
Variable interval
25. What is the most common one? - Testicular tumor in men over 50 years old
Testicular lymphoma
Ovarian cancer
A high - resistance system is formed when resistors are added in a series.
The oncotic pressure of plasma promotes reabsorption and is directly proportional to the filtration fraction.
26. What tumor is derived from primitive streak remnants and often contains bone - hair - or other tissue types?
Alcohol consumption
Sacrococcygeal teratoma
Uricosuric
Prostatic carcinoma
27. Name the most common type or cause - Rectal bleeding
Diverticulosis
eEF-1
Superego
Enterokinase
28. What is the most common condition leading to an intracerebral bleed?
Voltage - gated calcium channel
HTN
Metastatic carcinomas
Osteoclasts
29. Is the bound form or free form of a lipid - soluble hormone responsible for the negative feedback activity?
Primary spermatocyte
The sensory component is through the superior laryngeal nerve - and the motor limb is via the recurrent laryngeal nerve.
Free form determines hormone activity and is responsible for the negative feedback loop.
Hyperventilation - which decreases CO2 - shifting the reaction to the left and decreasing H+
30. What lecithin: sphingomyelin ratio indicates lung maturity?
2.0 or greater
Increase in ECF osmolarity means a in decrease in ICF osmolarity - so cells shrink.
DiGeorge syndrome
Ultralente
31. From What aortic arch are the following structures derived?
Punishment
Alcoholic cirrhosis
1. Masseter 2. Temporalis 3. Medial pterygoid 4. Lateral pterygoid
Stapes artery
32. What embryonic structure forms the adult male structure? - Corpus cavernosus - corpus spongiosum - and glans and body of the penis
Aortic insufficiency
Phallus
Intrapleural pressure decreases (becomes more negative).
von Gierke's disease
33. When does most REM sleep occur - in the first or second half of sleep?
REM sleep occurs more often in the second half of sleep. The amount of REM sleep increases as the night goes on.
Pontocerebellar angle syndrome
12 days after ovulation
Obese patients
34. Name the stages of sleep with these EEG patterns: x Disappearance of alpha waves - appearance of theta waves
Burkitt lymphoma
Facial expression (the second is vocal intonation)
EF-2 and GTP
Stage 1
35. Where is lithium metabolized and excreted?
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36. What component of the ETC is inhibited by the following? - Atractyloside
CN V1 carries the sensory and CN VII carries the motor component of the blink reflex.
SHIP: Shifting of the aorta - Hypertrophy of the right ventricle - Interventricular septal defect - Pulmonary stenosis
ATP/ADP Translocase
Asbestosis
37. Where does the synthesis of ACh occur?
In the cytoplasm of the presynaptic nerve terminal; it is catalyzed by choline acetyltransferase.
Stimulus generalization must stop. (Pairing of the unconditioned stimulus and the conditioned stimulus must cease.)
1. Sweat glands 2. Arterioles 3. Veins
Tip of the left ventricle
38. What are the three signs of morphine overdose?
Aspartame
Pinpoint pupils - decreased respiratory rate - and coma
The fast component is directed toward the affected side of a cerebellar lesion.
Labile
39. In a diabetic patient - to What does aldose reductase convert glucose?
Confidence interval. It is a way of admitting estimation for the population.
Fc portion of IgG - C3b - and mannose - binding proteins
total body water
Sorbitol (resulting in cataracts)
40. What virus is associated with body cavity large B- cell lymphomas?
Chromosome 5 - 21
CHF
HHV-8
Th2 cells
41. What chromosome is mutant in patients with cystic fibrosis?
Type III hypersensitivity (immune complex)
The AR form is malignant and AD is benign.
Cystadenocarcinoma
Patients with cystic fibrosis have a mutation in the chloride channel protein in the CFTR gene on chromosome 7.
42. What has occurred to the renal arterioles based on the following changes in the GFR - RPF - FF - and glomerular capillary pressure? - GFR ? - RPF ? - FF normal - capillary pressure ?
Hyaluronic acid (all sulfates bind to the core protein)
Dorsal prefrontal cortex
Chromosome 5p
Dilation of afferent arteriole
43. A 70-year - old man complains of urinary urgency - nocturia - hesitancy - postvoid dribbling - urinary retention - and a PSA result of 6.5 ng/mL. What is your diagnosis?
Hemosiderin
BPH. Although an argument can be made for prostatic cancer (you should expect a much higher PSA result) - these are buzzwords for BPH. Prostatic cancer is usually silent until late in the disease - when obstructive symptoms begin to occur.
Neisseria meningitides
ALA dehydrogenase and ferrochelatase
44. What drug causes a sixfold increase in schizophrenia - can impair motor activity - and can cause lung problems?
Marijuana
Streptococcus agalactiae
Variable interval
Stratum corneum (keratinized)
45. What is the term for the total percentage of correct answers selected on a screening test?
Contralateral. The spinothalamic tract enters the spinal cord and immediately synapses in the dorsal horn - crosses over - and ascends contralateral in the spinal cord - brainstem - thalamus - and postcentral gyrus.
Achalasia
Spermatogonia (type B)
Accuracy (think of it as all the trues - because they are the ones correctly identified)
46. What two classes of drugs can cause schizoid behavior?
Glucocorticoids and amphetamines
With opioid use the pupils become pinpoint (miosis) because of increased cholinergic activity.
Rectum
Peutz - Jeghers syndrome
47. How is sleep affected in a person with alcohol intoxication?
GH - especially IGF-1. GH also increases the incorporation of thymidine in DNA synthesis and uridine in RNA synthesis.
F- Met - Peptides
Small to medium - sized cerebral vessels
Decreased REM sleep and REM rebound during withdrawal
48. What pneumoconiosis is associated with exposure to the following occupations or materials? - Shipyards - brake linings - insulation - and old building construction
Asbestosis
Anterior tibial artery
The limbic system
Free - unprocessed Ag
49. T3 increases bone ossification through synergistic effect with what hormone?
Metaplasia (usually to a more protective cell type)
Although both pathways are associated with disinhibition - the indirect basal ganglia pathway is associated with a decreased level of cortical excitation.
NAVEL: Femoral Nerve - Artery - Vein - Empty space - and Lymphatics/Lacunar ligament
GH
50. What are the four capsular polysaccharides used in the Neisseria meningitides vaccine?
The myotatic reflex is responsible for the tension present in all resting muscle.
Y - W-135 - and C and A capsular polysaccharides
Penicillin G (benzylpenicillin)
P = .05; P < .05 rejects the null hypothesis
Can you answer 50 questions in 15 minutes?
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