Test your basic knowledge |

USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Name the muscle type based on these descriptions: x Discontinuous voluntary contraction - multinuclear striated unbranched fibers - actin and myosin overlapping for banding pattern - triadic T tubules - troponin and desmin as Z disc intermediate fila
Shortens
produce bile
Skeletal muscles
Leuprolide

2. What is the first membrane - bound Ig on B cell membranes?
IgM; IgD follows shortly thereafter.
Cingulate gyrus herniation (subfalcine)
HMG- CoA reductase
It is produced by the preload on the muscle prior to contraction.

3. From What embryonic structure are the following structures derived? - The right and left ventricles
Propionic acid
Primitive ventricle
X- linked recessive
Megaloblasts

4. Name the RNA subtype based on the following: x Found only in the nucleus of eukaryotes and functions to remove introns from mRNA
LGB (think EYES)
Chromosome 5
snRNA
HIV

5. Are the following major or minor Jones criteria of rheumatic fever? - Erythema marginatum
Major
Transport maximum (Tm) occurs when all function carriers are saturated and therefore is an index of the number of functioning carriers.
Bacillus anthracis
Schedule dependent; antineoplastic agents that work on nonproliferating cells are dose dependent

6. Are the following conditions associated with a negative or positive nitrogen balance? - AA deficiency
LCO - an index of lung surface area and membrane thickness - is decreased in fibrosis because of increased membrane thickness and decreased in emphysema because of increased surface area without increase in capillary recruitment; in exercise there is
Mycoplasma
Negative
Clindamycin

7. What restriction endonuclease site is destroyed in sickle Beta- globin allele?
Folic acid deficiency
GnRH constant infusion
MstII; changing codon 6 (from A to T) destroys the restriction site.
Tay- Sachs disease

8. What subtype of schizophrenia is characterized by x Stuporous mute echopraxia and automatic obedience - waxy flexibility with rigidity of posture?
Skin - liver - and kidneys
X- linked recessive
Splenic flexure
Catatonic schizophrenia

9. Name the AD disease associated with chromosome 15 in which the patient has long extremities - lax joints - pigeon chest - and posterior mitral leaflet prolapse and is prone to developing dissecting aortic aneurysm.
IL-3 (3 face down is an M)
Marfan syndrome
Positive sense RNA means it can serve as mRNA and therefore has 5'-3' polarity
Thermogenic

10. What artery travels with the following veins? - Small cardiac vein
Choriocarcinoma
Area 6
Right coronary artery
Stratum corneum (keratinized)

11. Name the nephritic disease based on the immunofluorescent staining - Mesangial deposits of IgA and C3
Methyldopa
IgA nephropathy (Berger disease)
Chronic alcoholic
Fatty acids cannot cross the blood - brain barrier; therefore - they cannot be used as an energy source.

12. Are sexually abused females more likely to have learning disabilities than the general population?
Bile pigments and bile salts
Skin - liver - and kidneys
Yes - by three to four times. Having multiple sexual partners - being overweight - and pelvic pain and/or inflammatory disorders are also likely to be seen in sexually abused females.
Terminal collecting duct has the highest concentration and Bowman's capsule has the lowest concentration of inulin.

13. What nucleus of the hypothalamus receives visual input from the retina and helps set the circadian rhythm?
Oligodendroglioma
Adenosine deaminase (ADA) deficiency
Suprachiasmatic nucleus
Ewing sarcoma

14. Name the type of necrosis - Histologically resembles fibrin
Fibrinoid necrosis
90% as HCO3- - 5% as carbamino compounds - and 5% as dissolved CO2
Magnesium
Renal plasma flow (decrease flow - increase FF)

15. How can a genetic deficiency of carbamoyl phosphate synthetase be differentiated from an ornithine transcarbamoylase deficiency?
1. Increase compliance 2. Decrease surface tension 3. Decrease probability of pulmonary edema formation
CMV - Toxoplasma gondii - and Listeria
Uracil and orotic acid levels increase with ornithine transcarbamoylase deficiency and are normal in carbamoyl phosphate synthetase deficiency.
The urine becomes hypertonic because of water reabsorption in the collecting duct.

16. What malignant bone tumor is associated with familial retinoblastoma?
Left atrium
Sideroblastic anemia
T cells - B cells - and macrophages
Osteosarcoma

17. What two PGs are used to induce labor?
Euchromatin - the dark stuff in the nucleus on an electron microscope image.
ELISA screens and Western blot confirms the diagnosis.
PGE2 and PGF2a
Achondroplasia

18. What is the greatest component of lung recoil?
Vanillylmandelic acid (VMA)
IL-8 (IL-1 and TNF- gamma also)
Surface tension; in the alveoli - it is a force that acts to collapse the lung.
Beryllium

19. What rate is indicated by 1- specificity?
Clonidine
Infrapatellar bursa
False - positive rate
Alcohol abuse

20. What are the pharmacologic effects seen sexually with x Beta- Blockers?
CD3
Isotonic contraction
RBCs. That is why it is called red pulp.
Impotence

21. Can committed mentally ill patients refuse medical treatment?
CN X (Remember - the vagus nerve supplies the parasympathetic information from the tip of the pharynx to the end of the midgut and all between.)
Yes. The only civil liberty they lose is the freedom to come and go as they please.
Cross - sectional studies determine prevalence - not incidence or cause and effect.
Leptospira

22. What embryonic week sees the formation of the notochord and the neural tube?
Dilation of afferent arteriole
Al - Anon
Ipsilateral loss below the level of the lesion
Third week

23. Describe the organism based on the following information: x Beta - Hemolytic Streptococcus; positive cAMP test; hydrolyzes hippurate
Lesch - Nyhan syndrome
Streptococcus agalactiae
Conduction aphasia
Sickle cell anemia - Caisson disease - chronic steroid use - and Gaucher disease

24. What cell in bone is a part of the mononuclear phagocytic system?
Osteoclasts
Transient hypogammaglobinemia of infancy; it usually resolves by age 16 to 30 months.
Thiabendazole
No - you never refuse to treat a patient simply because he or she can't pay. You are a patient advocate.

25. What chromosome is mutant in patients with cystic fibrosis?
Kawasaki disease
Patients with cystic fibrosis have a mutation in the chloride channel protein in the CFTR gene on chromosome 7.
Schedule dependent; antineoplastic agents that work on nonproliferating cells are dose dependent
IgD; IgM is also correct.

26. What is the most common one? - Tumor of the female genital tract
nef and tat genes
Metabolic rate and alveolar ventilation (main factor)
Bacillus anthracis
Leiomyoma (fibroids)

27. What is the major stimulus for cell division in chondroblasts?
Gastrinoma
The granule cell. Its neurotransmitter is glutamic acid - Which is also the principal neurotransmitter of the visual pathways.
Chromosome 5 - 21
IGF-1

28. What enzyme is deficient in the following glycogen storage disease? - von Gierke's disease
Glucose -6- phosphatase
Y - W-135 - and C and A capsular polysaccharides
Rochalimaea quintana (now called Bartonella quintana)
Breast cancer

29. What abdominal muscle runs horizontally - contributes to the posterior rectus sheath - and contributes to form the conjoint tendon?
CSF
Transverse abdominis
Round and ovarian ligaments
Dependent

30. What attaches the cusps of the valves to the papillary muscles in the heart?
Chordae tendineae
Osteoblast (Remember - blasts make - clasts take)
Peutz - Jeghers syndrome
Membranous septal defects are interventricular; a persistent patent ovale results in an interatrial septal defect.

31. What is the FiO2 of room air?
Lithium
Thyroid gland
0.21; it is a fancy way of saying 21% of the air is O2.
Salmonella typhi

32. Which region of the variable domain comprises the Ag - binding site of the Ab?
Translation
Hypervariable region (three per light chain; three per heavy chain)
Vitamin K
IgG

33. What are the three signs of morphine overdose?
NADPH oxidase
1. The lesser omentum (consisting of the hepatoduodenal and hepatogastric ligaments) 2. Falciform ligament 3. Coronary ligament of the liver 4. Triangular ligament of the liver Liver is ventral; all other ligaments are dorsal mesentery derivatives.
Positive predictive value
Pinpoint pupils - decreased respiratory rate - and coma

34. When referring to a series circuit - what happens to resistance when a resistor is added?
1. Cytotrophoblast 2. Syncytiotrophoblast 3. Extraembryonic mesoderm
Fructose -1 - 6- bisphosphatase
Resistance increases as resistors are added to the circuit.
Alzheimer's (dementia of Alzheimer's type - DAT). (Remember - Alzheimer's constitutes 65% of dementias seen in patients 65 years old.)

35. If the P value is less than or equal to .05 - What do you do to the null hypothesis?
Phase III. It is considered the definitive test.
Reject it
14 L - 33% of body weight
Haemophilus ducreyi

36. Name the compartment of the lower extremity and the nerve based on its movements - Flex the hip and extend the knee
Anterior compartment of the thigh - femoral nerve
Membrane conductance (think conductance = channels open)
Ventilation of an unperfused lung segment is highly suspicious for pulmonary embolism.
Somatization

37. Name the macrophages by location: x Kidney
Mesangial macrophages
Macule (e.g. - a freckle)
Escherichia coli
Alkaline phosphatase

38. What forms of fatty acids are absorbed from the small intestine mucosa by simple diffusion?
Arch of the aorta
Premature ejaculation
There would be a Fab' region; thus - it would still be able to participate in precipitation and agglutination.
Short - chain fatty acids

39. What two glycolytic enzymes catalyze the substrate - level phosphorylations?
Healing by secondary intention
Chromosome 5q21
The vermis
3- Phosphoglycerate kinase and pyruvate kinase; this produces two ATPs per enzyme (total four ATPs)

40. What respiratory center in the rostral pons has an inhibitory affect on the apneustic center?
Treacher Collins syndrome
Lesch - Nyhan syndrome
Paget disease (osteitis deformans)
Pneumotaxic center (short - fast breaths)

41. What is the label given to an individual whose IQ is x 80 to 89
Papillary carcinoma of the thyroid
1. Dilation of the afferent arteriole 2. Constriction of the efferent arteriole 3. Inhibition of reabsorption of sodium and water in the collecting ducts
Confounding bias
Low average

42. What law states that an enlarged - palpable gallbladder is more likely due to cancer than stone obstruction?

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

43. How are drugs that are excreted via the biliary system resorbed by the GI tract?
Enterohepatic cycling
Integument (skin and its derivatives)
Sleepwalking is associated with stage 4 and occurs most often in the first third of sleep.
Coccidioides immitis

44. What CN is associated with the x Sixth pharyngeal arch?
Microglia (Microglia and mesoderm both begin with M)
CN X
The hallmarks of LMN lesion injury are absent or decreased reflexes - muscle fasciculations - decreased muscle tone - and muscle atrophy What two areas of the skin do flaccid paralysis). Don't forget - LMN lesions are ipsilateral at the level of the
Adjustment disorder. It is a diagnosis of exclusion (used if no other choice).

45. What do UMNs innervate?
100% - with about 20% remaining positive after 1 year
They innervate LMNs.
LH has no effect on the production of adrenal androgens; ACTH stimulates adrenal androgen production.
Areas 44 and 45

46. Name the compartment of the mediastinum associated with the following thoracic structures: Left common carotid artery
Superior
Obese patients
Herpes I
It increases REM and total sleep time.

47. What are the five hormones produced by Sertoli cells?
Primary hypercortisolism
1. Inhibin 2. Estradiol (E2) 3. Androgen - binding protein 4. Meiosis inhibiting factor (in fetal tissue) 5. Antim
3- Phosphoglycerate kinase and pyruvate kinase; this produces two ATPs per enzyme (total four ATPs)
Seminoma

48. If a virus has positive sense RNA - can it be used as mRNA or is a template needed?
In the supraoptic nuclei of the hypothalamus; it is stored in the posterior pituitary gland.
Breast
Pseudomembranous colitis
Positive sense RNA can be used as mRNA. Negative sense RNA cannot be used as mRNA; it requires special RNA- dependent RNA polymerases.

49. What disorder of aldosterone secretion is characterized by x Decreased total body sodium - ECF volume - plasma volume - BP - and pH; increased potassium - renin - and AT II activity; no edema?

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

50. Blue - domed cysts
Anterior spinal artery
IgG
Fibrocystic change of the breast
Escherichia coli