Test your basic knowledge |

USMLE Step 1 Prep

Subjects : health-sciences, usmle-step-1

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Lucid interval
Nicotine (but it sure has a nasty withdrawal!)
Uroporphyrinogen III cosynthase
Epidural hematoma
Hematoxylin

2. What cell is under control of FSH and testosterone; secretes inhibin - MIF - and androgen - binding protein; and phagocytizes the excess cytoplasm of the spermatid?
Pernicious anemia
Hypnopompic hallucinations occur during awakening - whereas hypnagogic hallucinations occur while one is falling asleep.
Sertoli cell
Mitochondrial inheritance

3. What part of the inner ear contains the gravity receptors for changes in the position of the head?
Virchow triad - associated with the formation of a thrombus.
a - and Beta- chains are on most T cells.
Yes. It increases the rate of suicide to nearly 50 times that of the general population.
Saccule and utricle

4. Name the macrophage based on its location: x Liver macrophages
Wilson disease
Medulla blastoma
Onion skinning
Kupffer cells

5. On the venous pressure curve - What do the following waves represent? - V wave?
Antisocial personality
Anticentromere Abs
Atrial filling (venous filling) Atrial - Contraction - Venous
Primary spermatocyte

6. What level of mental retardation is characterized by x Being self - supportive with minimal guidance and able to be gainfully employed (includes 85% of the mentally retarded)?
Mild (50-70)
Gradient - time system
Major basic protein
Increased androgen secretion at puberty drives the increased GH secretion.

7. Name the antidote - Copper
D- Penicillamine
Lead
Methicillin
Cilia

8. What axis I disorder is characterized by pronoun reversal - preference for inanimate objects - obliviousness to the external environment - lack of separation anxiety - and abnormalities in language development?
5' deiodinase
Thick skin
At least 30% blast in the bone marrow
Autism. Head - banging - rocking - and self - injurious behaviors are also common in autism.

9. Curschmann spirals
Cytochrome c
Staphylococcus aureus
Gubernaculum
Bronchial asthma (whorled mucous plugs)

10. What substance do the JG cells of the kidney secrete in response to low blood pressure?
Psammoma bodies
Renin
Left anterior descending artery
Cholera toxin

11. Is the hydrophobic or hydrophilic end of the phospholipids of the cell membrane facing the aqueous environment?
Hydrophobic (water - insoluble) end faces the aqueous environment and the hydrophilic (water - soluble) end faces the interior of the cell.
Sickle cell disease
Gastric cancer
Metabolic rate and alveolar ventilation (main factor)

12. What is the term for precipitation of calcium phosphate in dying or necrotic tissue?
Dystrophic calcification
Confidence interval. It is a way of admitting estimation for the population.
2 NADPHs per acetyl CoA
Vitamin K deficiency has normal bleeding time and increased PT - and vitamin C deficiency has increased bleeding time and normal PT.

13. What vasculitis is characterized by systemic vasculitis in small to medium - size vessels (except the lung); affecting young males; 30% HBsAg - positive; P- ANCA and autoantibodies against myeloperoxidase?
Polyarteritis nodosa
Plummer - Vinson syndrome
LH
The sensory component is through the superior laryngeal nerve - and the motor limb is via the recurrent laryngeal nerve.

14. Which sedative - hypnotic is contraindicated for patients taking warfarin?
B cells; macrophages and dendritic cells are nonspecific.
Chloral hydrate
Isotonic contraction
Astrocytoma

15. What protein of the HIV virus does ELISA detect to determine whether a patient is HIV positive?
Areas 1 - 2 - and 3
Sucralfate
Borrelia recurrentis
P24

16. During What embryonic week does the intraembryonic coelom form?
Adrenarche
Third week
Graves disease
2% of population - 2 cm long - 2 feet from ileocecal valve - 2 years old - and 2% of carcinoid tumors

17. What has occurred to the renal arterioles based on the following changes in the GFR - RPF - FF - and glomerular capillary pressure? - GFR ? - RPF ? - FF normal - capillary pressure ?
Borrelia burgdorferi
Dilation of afferent arteriole
Hormone - sensitive lipase
Hormone - sensitive lipase - Which breaks down triglyceride into glycerol and free fatty acid

18. Does the heart rate determine the diastolic or systolic interval?
Dihydrofolate reductase
Medial nuclear group (limbic system)
Heart rate determines the diastolic interval - and contractility determines the systolic interval.
Variola (smallpox)

19. What is the key issue surrounding teenagers' maturation?
Formation of an identity through issues of independence and rebellion; they define who they are.
Yolk sac tumor
CN VII - IX - and X; taste and general sensation for the tongue is sent to the solitary nucleus.
Akathisia

20. Clue cells are associated with which organism that causes vaginal discharge?
Leiomyoma (fibroids)
Parallel circuit
Gardnerella vaginalis
Down syndrome

21. What is the longest and most convoluted segment of the nephron?
Surface tension; in the alveoli - it is a force that acts to collapse the lung.
PCT
alpha2- Receptors
Postductal coarctation of the aorta (adult)

22. Codman triangle on radiograph
Superior and posterior
Type I pneumocytes
Osteosarcoma
A positive AV difference indicates that a substance is extracted by the organ - and a negative difference indicates that it is produced by the organ.

23. Patients with ___________ have no Barr bodies.
Ego
Labioscrotal swelling
Subarachnoid hematoma
Turner syndrome

24. What is the region of the fallopian tube where fertilization most commonly occurs?
For the USMLE Step 1 the answer is no - but if the information would do more harm than good - withhold. This is very rare but it does occur.
Ampulla
Th2 cells
0.21; it is a fancy way of saying 21% of the air is O2.

25. What non - spore - forming gram - positive aerobic rod produces bull neck - sore throat with pseudomembranes - myocarditis - and sometimes respiratory obstructions?
Arsenic - thorotrast - and vinyl chloride
Corynebacterium diphtheriae
Transport maximum (Tm) occurs when all function carriers are saturated and therefore is an index of the number of functioning carriers.
Humerus (between the medial epicondyle and the trochlea)

26. What enzyme system is the most common form of phase II biotransformation?
Levator palpebrae superioris
Beta- Oxidation of fatty acids
A loss of afferent activity indicates a decrease in BP - and an increase in afferent activity indicates an increase in BP.
Glucuronidation

27. What HIV enzyme produces a dsDNA provirus?
Inspiratory reserve volume (IRV)
The greater the cell diameter - the greater the conduction velocity.
Muscles of the internal eye
Reverse transcriptase

28. What phase of the cell cycle are the following antineoplastic agents specific for? - Bleomycin
ACh receptor
G2 phase
Labile
Krukenberg tumor

29. Name the type of hypersensitivity reaction based on the following properties - Circulating Ab - Ag immune complexes deposited in the tissue result in neutrophil attraction and the release of lysosomal enzymes.
Type III hypersensitivity (immune complex)
The pulmonary vein - which carries oxygenated blood from the lung to the left atrium.
Lateral collateral ligament
Corticospinal tract

30. What two drugs block dopa - decarboxylase in the periphery to decrease the conversion of L- dopa to dopamine?
Left homonymous hemianopsia
Peyer's patch
Carbidopa and benserazide
impermeable to water

31. Name the RNA subtype based on the following: x Carries AA to the ribosome for protein synthesis
REM sleep occurs more often in the second half of sleep. The amount of REM sleep increases as the night goes on.
tRNA
Nephroblastoma
2 and 5HT3 receptors

32. What is the most common one? - Neurotransmitter in the brain
Processed antigenic peptides bound in the groove of the MHC molecule
Umbilical vein and ductus venosus (80%)
Breast
GABA - quantitatively

33. What hormone - produced by the granulose cell - stimulates the endometrium to enter the proliferative phase?
Middle meningeal artery
MstII; changing codon 6 (from A to T) destroys the restriction site.
Estrogen; the first 14 days of the female reproductive cycle mark the proliferative phase.
IgA nephropathy (Berger disease)

34. What is the most common one? - Tumor on sun - exposed sites
First M PITS for pharyngeal pouch derivatives
Glucose and galactose
9.3 L - 15% of body weight
Basal cell carcinoma

35. The DSM- IV- TR is scored on the basis of five axes of diagnosis. In What axis would you place x Psychosocial and environmental problems (stressors)?
Intrinsic. The extrinsic pathway is activated by the release of tissue factors.
Emphysema
Regular insulin
Axis IV

36. What cancer is particularly likely to affect English chimney sweeps?
Scrotal cancer - due to the high exposure to polycyclic aromatic hydrocarbons
Breathing high - pressure nitrogen over a long time and sudden decompression result in the bends.
LGB (think EYES)
Fitz - Hugh - Curtis syndrome

37. What is the effect of insulin on intracellular K+ stores?
Acamprosate (the number of glutamate receptors increases with chronic alcohol abuse)
Vesicle (e.g. - poison ivy)
Insulin increases intracellular K+ stores while decreasing serum K+ levels.
Flumazenil

38. Name the type of regeneration (i.e. - labile - stable - or permanent) based on the following examples - Smooth muscle
Stable
IL-4 is secreted to activate B cells. This begins the second step in the immune response - known as Activation. CD4 T cells secrete INF- alpha to activate macrophages
Alveolar macrophages
Range

39. What muscle keeps the stapes taut against the oval window?
Apneustic center (deep breathing place)
Stapedius muscle
Case fatality rate
Arthroconidia with hyphae

40. Name the most common type or cause - Chronic metal poisoning
Insulinoma
Reye syndrome
Corynebacterium diphtheriae
Lead

41. What GN is highly associated with hepatitis B and C infections?
Klinefelter syndrome
embranoproliferative glomerulonephritis (MPGN)
HBeAb
1. Iliocostalis 2. Longissimus 3. Spinalis ('I Love Science' muscles)

42. What disease is associated with the HLA- DR2 and HLA- DR3 alleles
EF- G of the 50S subunit
In the JG cells of the kidney
Systemic lupus erythematosus
Patent urachus

43. Name the Hgb - O2 binding site based on the following information: x Greatest affinity of the three remaining sites for attachment; requires PO2 levels of 26 mm Hg to remain attached
6 years old
Site 2
60%
Cyanocobalamin (B12)

44. In what stage of sleep is GH secreted?
Phase 3
Elongation factor - G and GTP
Terminal ileum
Stages 3 and 4 (NREM)

45. What are the primary neurotransmitters at the following sites? - Brainstem cells
Epidural hematoma
Neologisms. Thomas Jefferson noted - 'Necessity obliges us to neologize.' (Abnormal use of neologisms is known as neolalism.)
Serotonin
Amanita phalloides

46. What is the most common one? - Site of pancreatic cancer
Bronchial asthma (whorled mucous plugs)
1. Increased tube radius 2. Increased velocity 3. Decreased viscosity 4. Increased number of branches 5. Narrowing of an orifice
Fanconi - like syndrome
Head of the pancreas

47. What two regions of the vertebral column are considered primary curvatures?
Methionine (start) and tryptophan are the only two AAs with only one codon.
Cones (C for color and cones)
Type IV hypersensitivity reaction (delayed type because of the 48-96 hour latency)
Thoracic and sacral

48. What is the name for failure of the allantois to close - resulting in a urachal fistula or sinus?
EF-2 and GTP
Patent urachus
Yolk sac tumor
The one start codon - AUG - in eukaryotes codes for methionine and in prokaryotes formylmethionine.

49. What two Beta2- agonists are used to produce bronchodilation?
Thoracic and sacral
Metaproterenol and albuterol
Site 1
Superior

50. What nerve roots constitute the cervical plexus?
C1 through C4
Picornaviridae
Reaction formation
Subdural hematoma is a rupture of the cerebral veins where they enter the superior sagittal sinus.