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Biochemistry

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  • Answer 50 questions in 15 minutes.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. 90% of ADPKD cases are due to a mutation In what gene






2. What are the two transgenic strategies in mice






3. How do fluoroquinolones work






4. Which anticancer drugs work on microtubules






5. What is the trinucleotide repeat in fragile X






6. What is pseudohypertrophy in the calf a result of - and What are the cardiac manifestations






7. CF - is AR deletion In what gene On what chromosome resulting in a deletion inf what?






8. What is the function and name of vit B6






9. What tissues have only aldose reductase






10. What causes patau's syndrome and What is it






11. What apolipoprotiens are on VLDL






12. What collagen type is most frequently affected in ehlers danlos and What are common complications






13. What are the products for glycolysis






14. What are the 3 AR forms of homocystinuria






15. How does OTC def present






16. What does apoB100 do






17. Which direction does kinesin go






18. What converts tyrosine to DOPA






19. Which type of chromatin is less condensed - transcriptionally active - sterically accesible






20. What enzyme converts phenylalanine to tyrosin






21. How does insulin inhibit glycogenolysis






22. What are pyrimidines made from






23. Milder form of type I with nl blood lactate levels - dz and enzyme

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24. What does lactase deficiency cause






25. What is made fir rNucleotides or deoxyrNucleotides and what enzyme is necessary to convert one to the next






26. What does Citrate Is Krebs starting substrate for making oxaloacetate






27. What is the defect in I- hyperchylomicronemia






28. What trinucleotide repeat in Huntingtons and what chromosome is it found on...






29. depression - progressive dementia - choreiform movements - caudate atrophy and dec levels of GABA and ACH in the brain






30. How is ammonium transported from muscle to the liver for urea cycle






31. Fluorescent DNA or RNA probe binds to specific gene of interest - used for specific localization of genes and direct visualization of anomalies - like microdeletions - at molecular level






32. What converts DOPA to dopamine






33. How is orotic aciduria inherited






34. Which part of the DNA binds RNA polymerase and multiple other TFs upstream from gene locus






35. Why is G6PD def more common among patients of african decent






36. What is the amino acid precursor for catecholamines






37. Type I bone






38. What is the RDE of glycogenolysis






39. What does amino acid catabolsim results in the formation of what?






40. nucleotide repeat for fragile x






41. What is the activated carrier for aldehyddes






42. What defects characterize DiGeorge syndrome






43. congenital microdeletion of long arm of chromosoe 7 with findings of elfin facies - mental retardation - hypercalcemia - well developed verbal skills - extreme friendliness with strangers - cardiovascular problems






44. What enzyme results in classic galactosemia and What is the clinical






45. What is the RDE of the urea cycle






46. What is the prevalence of an X- linked recessive disease in males and in females






47. What enzyme becomes essential in PKU






48. What are ketone bodies made from - where are they metabolized and how are they excreted






49. cardiomegaly - systemic findings leading to early death - dz and enzyme

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50. What tissue samples are used for karyotyping







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