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Test your basic knowledge |
Chemistry Certification
Start Test
Study First
Subject
:
certifications
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The osmolality of a urine or serum specimen is measured by a change in the...
freezing point
lithium
4.5
bone
2. The most widely used support medium for electrophoretic separation of lipoproteins is...
primary hyperparathyroidism
B12 deficiency
agarose
alpha 2 beta
3. A serum sample for acid phosphatase determination is best prepared for room temperature storage by...
enzyme immunoassay
adding an acid stabilizer
valine leucine isoleucine
check serum for hemolysis
4. An automated CK assay gives a reading that is above the limits of linearity. A dilution of the serum sample is made by adding 1 mL of serum to 9 mL of water. The instrument now rew 350 U/L. The correct report on the undiluted serum should be...
measures one ion more than others
standard
3500
glucose
5. Oligoclonal bands are present on electrophoresis of concentrated CSF and also on concurrently tested serum of the same patient. The proper interpretation is...
HPLC analysis of porpobilinogen on 24hr urine
nondiagnostic for MS
apoenzyme
intestinal malabsorption
6. Gel filtration chromatography is used to separate...
ammonia
cmpds based on molecular weight and size
pH pCO2 pO2
measures one ion more than others
7. If a drug has a half-life of 7 hours - how many doses given at 7-hour intervals does it usually take to achieve a steady state or plateau level?
5
B12 deficiency
valine leucine isoleucine
SD over mean
8. A patient in her 33rd week of pregnancy is hospitalized with toxemia. Her doctor would like to deliver the baby early because the toxemia is becoming more severe. The baby's best chance of delivery without respiratory distress due to lung immaturity
enzyme immunoassay
measurement of absorbance at 450
2Na + glucose over 20 + BUN over 3
L/S ratio > 3.5
9. This method employs a highly specific antibody to thyroxine
fall in pH - rise in pCO2
exchange of amino and keto groups
T4 by RIA
no decrease in serum growth hormone after 90 minutes
10. A chemiluminescent EIA...
cmpds based on molecular weight and size
porphobilinigen SCREEN
is quantitated by the amount of light produced
nondiagnostic for MS
11. A 2-year-old child with a decreased serum T4 is described as being somewhat dwarfed - stocky - overweight - and having coarse features. Of the following - the most informative additional laboratory test would be the serum...
D
TSH
2-log(T)
exposure to CO
12. A spectrophotometer is being considered for purchase by a small laboratory. This specification reflects the spectral purity of the instrument
growth - third trimester of pregnancy
Tay-sachs
band width
patient noncompliance
13. Assay of transketolase activity in blood is used to detect deficiency of...
dirty applicators
chloride
thiamine
purulent
14. The direction in which albumin migrates (ie - toward anode or cathode) during electrophoretic separation of serum proteins - at pH 8.6 - is determined by...
ionization of carboxyl groups (yielding a net negative charge)
growth - third trimester of pregnancy
creatine kinase
GGT
15. Serum anion gap is increased in patients with...
carbohydrate hyperalimentation
lactic acidosis
specificity
parathyroid
16. Blood received in the laboratory for blood gas analysis must meet these requirements
no ice clots bubbles
binding capacity of thyroxine-binding globulin
boderline results test should be repeated
100 nmol
17. A 25-year-old man became nauseated and vomited 90 minutes after receiving a standard 75-g carbohydrate dose for an oral glucose tolerance test. The best course of action is...
draw blood for glucose and discontinue test
ammonia
B12 deficiency
endosmosis
18. A patient had the following serum results: Na+ 140 mEq/L K+ 4.0 mEq/L Glucose 95 mg/dL BUN 10 mg/dL Which osmolality is consistent with these results?
bicarbonate buffer
pH pCO2 pO2
270
parathyroid
19. This is a glycolytic enzyme that catalyzes the cleavage of fructose-1 - 6-diphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate
5 tri 15 cholesterol 50 protein
increase in total circulating T4
urobilin
aldolase
20. In the immunoinhibition phase of the CK-MB procedure...
carbohydrate hyperalimentation
Calcium - phosphorus
Solute moves half the distance of the solvent front
M subunit is inactivated
21. This condition does decrease activity of glucuronyl transferase result in increased unconjugated bilirubin and kernicterus in neonates
electric current
crigler
measurement of absorbance at 450
thyroxine binding globulin
22. Patients with Cushing's syndrome exhibit...
triglycerides
serum cortisol > 15
urinary free cortisol
oxalacetate to malate
23. Total iron-binding capacity measures the serum iron transporting capacity of...
M subunit is inactivated
<45
thiamine
transferrin
24. The osmolal gap is defined as measured Osm/kg minus the calculated Osm/kg. The average osmolal gap is near...
<45
0
measurement of absorbance at 450
alkaline picrate
25. Serum from a patient with metastatic carcinoma of the prostate was separated from the clot and stored at room temperature. The following results were obtained: Patient Reference Range Calcium: 10.8 mg/dL 8.8-10.3 mg/dL LD:420 U/L 50-150 U/L Acid phos
M subunit is inactivated
ALP with fresh draw
Solute moves half the distance of the solvent front
65
26. A 45-year-old woman complains of fatigue - heat intolerance - and hair loss. Serum thyroxine and 125I-T3 resin uptake are abnormally low. What test would confirm that this is a pituitary deficiency?
urinary free cortisol
TSH
parathyroid
D
27. In the liver - bilirubin is converted to...
correct for variations in light intensity
2-log(T)
ionic charge
bilirubindiglucuronide
28. The enzyme that exists chiefly in skeletal muscle - heart - and brain; is grossly elevated in active muscular dystrophy; and rises early in myocardial infarction is...
acute hepatitis
thymolpthalein monophosphate
creatine kinase
ratio of distance moved by solvent to distance moved by compound
29. The most heat labile fraction of alkaline phosphatase is obtained from...
bone
LDH
trig
metabolic acidosis
30. Specimens for blood gas determination should be drawn into a syringe containing...
amytriptyline 104
heparin
creatinine
potassium dichromate in SA
31. The formula for calculating the amount of moles of a chemical?
CO2
g/MW
hepatobiliary (obstruction?)
specimen exposure to light
32. Kernicterus is an abnormal accumulation of bilirubin in...
brain
corticosterone
increased O2 decreased HCO3
iron hemochromatosis
33. Most most likely to be ordered in addition to serum calcium to determine the cause of tetany?
Mg
testosterone
attaching them to protein molecules
parathyroid hormone
34. Alkaline phosphatase Slight increase - Aminotransferase Marked increase - Aspartate aminotransferase Marked increase - Alanine gamma-glutamyl transferase Slight increase
metabolic acidosis
can be used for absorbtion - partition - ion exchange - and gel permeation chromatography
B12 deficiency
acute hepatitis
35. Upon completion of a run of cholesterol tests - the technician recognizes that the controls are not within the two standard deviations confidence range. What is the appropriate course of action
run a new set of controls
iron deficiency anemia
Temperature is a function of the number of particles in solution
can be separated into distinct phenotypes
36. In developing the reference for a new EIA for CEA - the range for the normal population was broader than that published by the vendor. Controls are acceptable with a narrow coefficient of variation. This may be explained by...
attaching them to protein molecules
inclusion of smokers and nonsmokers in the study population
Tangier
purulent
37. A new method is being evaluated. A recovery experiment is performed with the following results: 0.9 mL serum sample + 0.1 mL H20 = 89 mEq/L 0.9 mL serum sample + 0.1 mL analyte std. @ 800 mEq/L = 161 mEq/L The percent recovery of the added analyt
high co2 and hco3
90%
100nmol
maintain colloidal osmotic pressure
38. Creatinine clearance is used to estimate the...
didymium filter
MI
run a new set of controls
GFR
39. Estrogen and progesterone receptor assays are useful in assessing prognosis in...?
breast cancer
hyperthyroidism
270
20:1
40. In electrophoresis of serum proteins - arifacts at the application point are most frequently caused by...
dirty applicators
ammonia
one micromole/minute
a small concentration of APO-B containing lipoproteins after precipitation
41. An automated method for measuring chloride that generates silver ions in the reaction is...
methadone
1 micromole per minute
coulometry
bicarbonate carbonic acid
42. The Porter-Silber method (phenylhydrazine in alcohol and sulfuric acid) involves which part of the steroid molecule?
dihydroxyacetone side chain
didymium filter
corticosterone
21-hydroxylase deficiency
43. A common cause of a falsely increased LD1 fraction of lactic dehydrogenase is...
5
hemolysis
lead
conjugated hyperbilirubinemia - hepatocellular obstruction
44. The following data were obtained from a cellulose acetate protein electrophoresis scan: Albumin area 75 units Gamma globulin area 30 units Total area 180 units Total protein 6.5 g/dL The gamma globulin content in g/dL is...
parathyroid
prostate
1.1
freezing point
45. Before unconjugated bilirubin can react with Ehrlich's diazo reagent - this must be added
crigler
methyl alcohol
Prolactin
maintain colloidal osmotic pressure
46. Diagnostic specificity is defined as the percentage of individuals...
bone
WITHOUT a disease with a negative test
tissue and serum levels need to reach equilibrium
Hb S
47. The most consistent analytical error involved in the routine determination of HDLcholesterol is caused by...
boderline results test should be repeated
the fetus is at risk for respiratory distress
a small concentration of APO-B containing lipoproteins after precipitation
pituitary
48. Upon development of a thin layer chromatogram for the drug analysis - all drug spots (including the standards) had migrated with the solvent front. The most probable cause for this would be...
incorrect aqueous to nonaqueous mixture
BUN 80
SD over mean
1 mol/kg
49. The measurement of light scattered by particles in the sample is the principle of...
nephelometry
chylomicrons
ratio of distance moved by solvent to distance moved by compound
can be separated into distinct phenotypes
50. The extent to which measurements agree with or approach the true value of the quantity being measured is referred to as...
accuracy
1.1
hemolysis
1 micromole per minute