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First Aid Basics

Subjects : health-sciences, first-aid

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Retinoblastoma - osteosarcoma 13q tumor suppressor (blocks G1 to S phase progression)
Rb gene
malignant epithelial tumor
prostate cancer incidence/mortality
blood vessels malignant tumor

2. PECAM-1
WT1 gene
Alk - phos
Leukocyte extravasation: diapedesis
secondary amyloidosis (reactive systemic)

3. Tumor marker: pancreatic adenocarcinoma
Autoimmune (Hashimoto's - myasthenia gravis)
CA-19-9
aflatoxin target
p16 gene

4. Colon carcinoma GTPase (oncogene)
malignant epithelial tumor
beta - hCG
ras gene
Chronic inflammatory mediators

5. Colorectal cancer (assoc with FAP) 5q tumor suppressor
Alk - phos
fat benign tumor
p16 gene
APC gene

6. Lung (mesothelioma and bronchogenic carcinoma)
asbestos target
c - kit gene
abl gene
acanthosis nigricans (hyperpig and epidermal thickening)

7. Bacterial products (CLIK):C5a - LTB4 - IL-8 - Kallikrein
Alk - phos
Leukocyte extravasation: migration
BRCA1 gene
bcl -2 gene

8. Tumor marker: Screen for prostate carcinoma. Can also be elevated in BPH and prostatitis.
NF2 gene
PSA
malignant >1 cell type tumor
Leukocyte extravasation: migration

9. Lung tumor transcription factor (oncogene)
L- myc gene
paraneoplastic effects of small cell lung carcinoma and intracranial neoplasms
p53 gene
Leukocyte extravasation: rolling

10. Rhabdomyosarcoma
aflatoxin target
acanthosis nigricans (hyperpig and epidermal thickening)
skeletal muscle malignant tumor
intrinsic apoptosis

11. Anaplasia - neoplasia - desmoplasia (fibrous tissue formation in response to neoplasm)
Irreversible - plasias
L- myc gene
Neoplasm associated with xeroderma pigmentosum (albinism)
Neoplasm associated with Down Syndrome

12. Colonic adenocarcinoma
ulcerative colitis
benign >1 cell type tumor
Leukocyte extravasation: rolling
Neoplasm associated with xeroderma pigmentosum (albinism)

13. Enzymes: catalase - superoxide dismutase - glutathione peroxidase.Vitamins: ACE Spontaneous decay
Red (hemorrhagic) infarcts
Free radical eliminators
intrinsic apoptosis
paraneoplastic effects of renal cell carcinoma - hemangioblastoma

14. Melanoma - basal cell carcinoma - and especially squamous cell carcinomas of the skin.
Neoplasm associated with xeroderma pigmentosum (albinism)
vinyl chloride target
Chronic inflammatory mediators
L- myc gene

15. Aggressive malignant lymphomas (non - Hodgkin's) and Kaposi's sarcoma
AIDS
asbestos target
Neoplasm associated with actinic keratosis
c - kit gene

16. Lung - liver - intestine or following reperfusion.
blood vessels malignant tumor
smooth muscle benign tumor
Red (hemorrhagic) infarcts
paraneoplastic effects of small cell lung carcinoma

17. Burkitt's lymphoma transcription factor (oncogene)
cigarette smoke target
skeletal muscle benign tumor
c - myc gene
extrinsic apoptosis

18. Neurofibromatosis type 1 17q tumor suppressor
asbestos target
NF1 gene
Where you see Psammoma bodies
malignant epithelial tumor

19. Osteoma
CCl4 target
cigarette smoke target
bone benign tumor
PSA

20. Mature teratoma in men or malignant teratoma in M/F
c - myc gene
paraneoplastic effects of small cell lung carcinoma and intracranial neoplasms
Autoimmune (Hashimoto's - myasthenia gravis)
malignant >1 cell type tumor

21. Neutrophils (eos in the gut) - plus other granular leukocytes and antibodies.
AIDS
Acute inflammatory mediators
DPC gene
APC gene

22. Cancer
Plummer - Vinson syndrome (atrophic glossitis - esophageal webs - anemia)
Second - leading cause of death in the US
extrinsic apoptosis
paraneoplastic effects of small cell lung carcinoma and intracranial neoplasms

23. 32%/13% male
S-100
c - kit gene
prostate cancer incidence/mortality
paraneoplastic effects of SqC lung carcinoma - renal cell carcinoma and breast carcinoma.

24. ACTH or ACTH- like peptide
paraneoplastic effects of small cell lung carcinoma and intracranial neoplasms
paraneoplastic effects of small cell lung carcinoma
Leukocyte extravasation: tight binding
p16 gene

25. Squamous cell carcinoma of the esophagus
Plummer - Vinson syndrome (atrophic glossitis - esophageal webs - anemia)
c - myc gene
p16 gene
nitrosamines (smoked foods) target

26. Membrane lipid peroxidation - protein modification and DNA breakage.
Free radical cell damage
iron poisoning
aflatoxin target
cirrosis (alcohol - hepB or C)

27. Colon cancer (Deleted in Colon Cancer) 18q tumor suppressor
paraneoplastic effects of small cell lung carcinoma and intracranial neoplasms
DCC gene
CA-19-9
aflatoxin target

28. Liver (angiosarcoma)
abl gene
DCC gene
vinyl chloride target
Second - leading cause of death in the US

29. Squamous cell carcinoma of skin
Autoimmune (Hashimoto's - myasthenia gravis)
Napthalene (aniline) dyes target
Neoplasm associated with actinic keratosis
Bombesin

30. Hyperuricemia (excess NA turnover)
paraneoplastic effects of leukemias and lymphomas
Where you see Psammoma bodies
dysplastic nevus
fat malignant tumor

31. Prostate (blastic) - thyroid - testes - breast (lytic and blastic) - lung (lytic) - kidney (breast and prostate are most common)
erb - B2 gene
Primary tumors that met to bone
TRAP
Plummer - Vinson syndrome (atrophic glossitis - esophageal webs - anemia)

32. Macrophages and lymphocytes. Persistant destruction and repair.
PSA
Chronic inflammatory mediators
nitrosamines (smoked foods) target
fat benign tumor

33. Sickle cell (altered shape) - polycythemia (too many) - CHF (unknown)
abl gene
NF1 gene
paraneoplastic effects of small cell lung carcinoma
causes of decreased ESR

34. Breast cancer 13q tumor suppressor (DNA repair protein)
Where you see Psammoma bodies
Second - leading cause of death in the US
cirrosis (alcohol - hepB or C)
BRAC2 gene

35. Leiomyosarcoma
Reversible - plasias
Leukocyte extravasation: diapedesis
smooth muscle malignant tumor
Paget's bone disease

36. Heart disease
BRCA1 gene
Leading cause of death in the US
Resolution of inflammation
Necrosis

37. Bladder (transitional cell carcinoma)
Napthalene (aniline) dyes target
S-100
benign epithelial tumor
Free radical cell damage

38. Secondary osteosarcoma and fibrosarcoma

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39. Tumor marker: thyroid medullary carcinoma
ret gene
Neoplasm associated with chronic atrophic gastritis - pernicious anemia - postsurgical gastric remants
calcitonin
primary amyloidosis

40. Liver (centrilobular necrosis - fatty change)
CCl4 target
Bombesin
Leukocyte extravasation: tight binding
Where you see Psammoma bodies

41. All - AML
Neoplasm associated with Down Syndrome
Second - leading cause of death in the US
DPC gene
Irreversible - plasias

42. Angiosarcoma
Leukocyte extravasation: migration
bone malignant tumor
Leukocyte extravasation: diapedesis
blood vessels malignant tumor

43. GIST cytokine receptor (oncogene)
ulcerative colitis
granulomatous disease
c - kit gene
Second - leading cause of death in the US

44. Adenoma - papilloma
benign epithelial tumor
Acute inflammatory mediators
L- myc gene
prostate cancer incidence/mortality

45. Hyperplasia - metaplasia - dysplasia
fat malignant tumor
c - myc gene
Reversible - plasias
ras gene

46. Pancreatic cancer (Deleted in Pancreatic Cancer) 18q tumor suppressor
DPC gene
Napthalene (aniline) dyes target
CA-125
erb - B2 gene

47. Colon>stomach>pancreas>breast>lung (liver and lung are the most common places for mets)
Primary tumors that met to liver
ras gene
ret gene
BRAC2 gene

48. Papillary (thyroid) - Serous (ovary) - Meningioma - Mesothelioma
alpha - fetoprotein
skeletal muscle benign tumor
paraneoplastic effects of SqC lung carcinoma - renal cell carcinoma and breast carcinoma.
Where you see Psammoma bodies

49. Follicular and undifferentiated lymphomas anti - apoptotic molecule (oncogene)
paraneoplastic effects of SqC lung carcinoma - renal cell carcinoma and breast carcinoma.
TRAP
Free radical cell damage
bcl -2 gene

50. Neuroblastoma transcription factor (oncogene)
Alkylating agents target
malignant mesenchyme tumor (general)
N- myc gene
intrinsic apoptosis

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First Aid Basics

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