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First Aid Basics

Subjects : health-sciences, first-aid

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. PTH- related peptide - TGF- beta - TNF - IL-1
paraneoplastic effects of SqC lung carcinoma - renal cell carcinoma and breast carcinoma.
L- myc gene
Neoplasm associated with tuberous sclerosis (facial angiofibroma - seizures - mental retardation)
malignant epithelial tumor

2. Restoration of normal structure - granulation tissue (vascularized + fibrosis) - abscess (fibrosis + pus) - fistula or scarring (collagen).
arsenic target
Resolution of inflammation
Neoplasm associated with actinic keratosis
Primary tumors that met to bone

3. Malignant lymphoma
Napthalene (aniline) dyes target
erb - B2 gene
paraneoplastic effects of leukemias and lymphomas
immunodeficiency states

4. Lung - liver - intestine or following reperfusion.
Red (hemorrhagic) infarcts
granulomatous disease
bone malignant tumor
Leading cause of death in the US

5. Breast cancer 13q tumor suppressor (DNA repair protein)
malignant mesenchyme tumor (general)
BRAC2 gene
extrinsic apoptosis
alpha - fetoprotein

6. Tumor marker: Screen for prostate carcinoma. Can also be elevated in BPH and prostatitis.
PSA
acanthosis nigricans (hyperpig and epidermal thickening)
Alk - phos
Leukocyte extravasation: tight binding

7. MEN type II and III tyrosine kinase (oncogene)
ret gene
Neoplasm associated with chronic atrophic gastritis - pernicious anemia - postsurgical gastric remants
APC gene
Primary tumors that met to liver

8. Gastric adenocacinoma
Alkylating agents target
smooth muscle benign tumor
causes of increased ESR
Neoplasm associated with chronic atrophic gastritis - pernicious anemia - postsurgical gastric remants

9. Esophageal adenocarcinoma

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10. AA
Free radical eliminators
secondary amyloidosis (reactive systemic)
beta - hCG
acanthosis nigricans (hyperpig and epidermal thickening)

11. Hyperplasia - metaplasia - dysplasia
Neoplasm associated with actinic keratosis
Resolution of inflammation
blood vessels benign tumor
Reversible - plasias

12. Larynx (SqCC) - lung (SqCC and SCC) - kidney (renal cell carcinoma) - bladder (transitional cell carcinoma)
cigarette smoke target
Colon and rectal cancer incidence
WT1 gene
benign epithelial tumor

13. Neurofibromatosis type 2 22q tumor suppressor (key type 2=22)
malignant mesenchyme tumor (general)
NF2 gene
iron poisoning
cirrosis (alcohol - hepB or C)

14. Leiomyoma
breast cancer incidence/mortality
paraneoplastic effects of thymoma - small cell lung carcinoma
BRAC2 gene
smooth muscle benign tumor

15. Adenocarcinoma - papillary carcinoma
bone benign tumor
extrinsic apoptosis
Neoplasm associated with actinic keratosis
malignant epithelial tumor

16. Colonic adenocarcinoma
ulcerative colitis
Second - leading cause of death in the US
p53 gene
Resolution of inflammation

17. All - AML
Neoplasm associated with Down Syndrome
ulcerative colitis
radiation exposure
Chronic inflammatory mediators

18. Anaplasia - neoplasia - desmoplasia (fibrous tissue formation in response to neoplasm)
Primary tumors that met to brain
Irreversible - plasias
WT1 gene
paraneoplastic effects of leukemias and lymphomas

19. Membrane lipid peroxidation - protein modification and DNA breakage.
bone malignant tumor
Free radical cell damage
fat benign tumor
erb - B2 gene

20. Vascular: E and P- selectin Leukocyte: Sialyl Lewis
nitrosamines (smoked foods) target
Leukocyte extravasation: rolling
Primary tumors that met to brain
primary amyloidosis

21. Lung (mesothelioma and bronchogenic carcinoma)
radiation exposure
asbestos target
vinyl chloride target
immunodeficiency states

22. Neuroblastoma transcription factor (oncogene)
DCC gene
Free radical cell damage
N- myc gene
blood cell malignant tumors

23. Melanoma 9p tumor suppressor
Paget's bone disease
vinyl chloride target
acanthosis nigricans (hyperpig and epidermal thickening)
p16 gene

24. Bladder (transitional cell carcinoma)
Napthalene (aniline) dyes target
Neoplasm associated with tuberous sclerosis (facial angiofibroma - seizures - mental retardation)
malignant epithelial tumor
Leading cause of death in the US

25. Mature teratoma in women
nitrosamines (smoked foods) target
TRAP
Prostatic acid phosphatase
benign >1 cell type tumor

26. Enzymatic degradation and protein denaturation due to exogenous injury. Inflammatory process where intracellular components extravasate.
vinyl chloride target
BRAC2 gene
AIDS
Necrosis

27. Wilms' tumor 11p tumor suppressor
benign >1 cell type tumor
WT1 gene
breast cancer incidence/mortality
prostate cancer incidence/mortality

28. Tumor marker: (Normal in fetus). Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis.
alpha - fetoprotein
N- myc gene
blood vessels benign tumor
Second - leading cause of death in the US

29. Follicular and undifferentiated lymphomas anti - apoptotic molecule (oncogene)
L- myc gene
bcl -2 gene
Pale infarcts
Barrett's esophagus (chronic GI reflux)

30. During embryogenesis - hormone induction and atrophy. Increased mitochondrial permeability and cytochrome c release. Increase Bax (pro - apoptotic) - decreased Bcl -2 (anti - apopotic).
lung cancer incidence/mortality
causes of decreased ESR
Second - leading cause of death in the US
intrinsic apoptosis

31. Most human cancers - specifically Li - Fraumeni syndrome 17p tumor suppressor (blocks G1 to S phase progression)
Primary tumors that met to bone
Necrosis
paraneoplastic effects of small cell lung carcinoma and intracranial neoplasms
p53 gene

32. Liposarcoma
malignant epithelial tumor
Reversible - plasias
Autoimmune (Hashimoto's - myasthenia gravis)
fat malignant tumor

33. Solid tissues with single blood supply. Heart - kidney and spleen.
Pale infarcts
ras gene
nitrosamines (smoked foods) target
causes of decreased ESR

34. TB - fungal infections - syphilis - leprosy - cat scratch fever - sarcoid - Crohn's - Berylliosis.
aflatoxin target
Acute inflammatory mediators
granulomatous disease
bone malignant tumor

35. Pancreatic cancer (Deleted in Pancreatic Cancer) 18q tumor suppressor
DPC gene
paraneoplastic effects of small cell lung carcinoma
abl gene
TRAP

36. Colon>stomach>pancreas>breast>lung (liver and lung are the most common places for mets)
Leukocyte extravasation: tight binding
Irreversible - plasias
Primary tumors that met to liver
causes of increased ESR

37. Liver (centrilobular necrosis - fatty change)
CCl4 target
Rb gene
Irreversible - plasias
N- myc gene

38. Lung - breast - skin (melanoma) - kidney (renal cell carcinoma) - GI.50% brain tumors are from mets
granulomatous disease
lung cancer incidence/mortality
Neoplasm associated with Down Syndrome
Primary tumors that met to brain

39. Hemangioma
paraneoplastic effects of SqC lung carcinoma - renal cell carcinoma and breast carcinoma.
Primary tumors that met to liver
dysplastic nevus
blood vessels benign tumor

40. Mature teratoma in men or malignant teratoma in M/F
malignant >1 cell type tumor
causes of decreased ESR
DPC gene
aflatoxin target

41. Neurofibromatosis type 1 17q tumor suppressor
Chronic inflammatory mediators
CEA
blood vessels benign tumor
NF1 gene

42. Infections - inflammation - cancer - pregnancy - SLE
extrinsic apoptosis
causes of increased ESR
Napthalene (aniline) dyes target
blood vessels benign tumor

43. PECAM-1
Where you see Psammoma bodies
malignant epithelial tumor
Leukocyte extravasation: diapedesis
skeletal muscle benign tumor

44. Lymphoma

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45. AL
breast cancer incidence/mortality
primary amyloidosis
fat malignant tumor
WT1 gene

46. Colon cancer (Deleted in Colon Cancer) 18q tumor suppressor
breast cancer incidence/mortality
CA-125
DCC gene
p53 gene

47. Ligand - receptor interactions. Release of perforin and granzyme B.
malignant epithelial tumor
asbestos target
bcl -2 gene
extrinsic apoptosis

48. Esophagus - stomach
PSA
nitrosamines (smoked foods) target
Neoplasm associated with chronic atrophic gastritis - pernicious anemia - postsurgical gastric remants
Primary tumors that met to brain

49. Antibodies to presynaptic Ca2+ channels at NM junction
radiation exposure
Pale infarcts
paraneoplastic effects of thymoma - small cell lung carcinoma
acanthosis nigricans (hyperpig and epidermal thickening)

50. Papillary (thyroid) - Serous (ovary) - Meningioma - Mesothelioma
Neoplasm associated with actinic keratosis
Where you see Psammoma bodies
intrinsic apoptosis
vinyl chloride target

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First Aid Basics

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