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First Aid: Biochemistry Molecular

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Prokaryotic only. Elongates leading strand by adding deoxynucleotides to the 3prime end. Elongates laggin strand. 3 prime to 5 prime exonuclease activity






2. Retrograde to microtubules






3. Checkpoints control transition between phases of cell cycle. regulated by cyclins - CDKs and tumor suppressors. Mitosis (shortest phse)






4. Bm - kidney - ears and eyes






5. Neurons






6. Neuroglia






7. Cilia - glagella - mitotic spindle - neurons - centrioles






8. Inhibits thymidylate synthase down thymine






9. 1 RNA polymerase (multisubunite complex) makes all 3 kinds of RNA






10. Introns stay In the nucleus whereas EXons EXit and are EXpressed






11. ATP






12. Completed protein is released from ribosme through simple hydrolosis and dissociates






13. H1






14. Attachment of ubiquitin to defective proteinds to tag them for breakdown






15. 3 sodium out for 2 potassium in (nout - kin)takes 1 atp and the machine is phosphorylated during the machine cycle






16. Genetic code is conserved throughout evolution






17. P53 and RB normally inhibit g1 to S progression






18. Connective tissue






19. Cylindrical structure composed of helical array of plymerized dimers of alpha and beta tubulin - flagella - cilia - mitotic spindle - grows slowly collapses quickly






20. Change resulting in early stop codon






21. Inhibit formation of the initation complex and cause misreading of mRNA






22. ATP ase that links peripheral 9 doublets and causes bending of cilium by differential sliding of doublets






23. Phosphorylation - glycosloation - hyderoxylation






24. Makes an RNA primer on which DNA polymerase II can initiate replication






25. Microvilli - muscle contraction - cytokinesis - adhering juntions






26. Type III






27. More than 1 codon may code for the same amino acid






28. Anti cancer - act on microtubules






29. Methionine - which may be removed before translation is completed






30. Inhibits bacterials dihydrofolate reducatese down thymine






31. Genetic bone disorder (brittle bone disease) type 1 colalgen - fractures (during birth) 2) Blue sclerae 3) hearing loss 4) dental imperfections 1:10000 may be confused with child abuse






32. Antigout - acts on mts






33. Aminoacyl - tRNA binds to A site 2) peptidyltransferase catalyzes peptide bond formation transfers growing polypeptie to amino acid in A site 3) ribosome advances 3 nucleotides toward the 3 prime end of RNA moving peptiydyl RNA to P site






34. Each codon specifies only 1 amino acid






35. Stretch of DNA that alters gene expression by binding transcription factors






36. Muscle






37. Y shaped region along DNA template where leading and lagging strands are syntehsized






38. Site where negative regulators bind






39. Neurons - skeletal - and cardiac muscle - RBCs






40. 75-90 nucleotides - 2ary structure cloverleaf form anticodon end is opposite 3 prime aminoacyl end






41. No proofreading function but can initiate chains. RNA poymerase II opens DNA at promoter site






42. 2 H bonds greater GC content greater melting point






43. Site where RNA polymerase and multiple other transciption factors bind to DNA upstream from gene locus (AT rich upstream sequence with TATA and CAAT boxes)






44. Unmethylated - newly synthesized string is recognized - mismatched nucleotides are removed and the gap is filled and resealed






45. Site of dteroid synthesis and detoxification of druigs and poisons (liver hepatocytes and steroid horomore adrenal cortex)






46. The N to C






47. Specific endonucleases release the oligonucleotide containing damaged bases. DNA polymerase and logase fill and resealt eh gap






48. Cyclin depndent kinases; consituative and inactive






49. You glyucosolate hte pro - alpha chain lysine resudens and form procollagen (triple helix of alpha chains)






50. Ketone