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First Aid: Biochemistry Molecular

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. ATP- AMP (2 phosphoanhydride bonds)






2. Microtubule polymerization defect resulting in lowered phagocytosis. results in recurrent pyogenic infections - partial albinism and peripheral neuropathy






3. Does not






4. HS1 - HSB - H2 - H4






5. Particular sequnece in genomre where DNA replication begins. May be single (prokaryotes) or multiple (eukaryotes)






6. Attachment of ubiquitin to defective proteinds to tag them for breakdown






7. Inhibit formation of the initation complex and cause misreading of mRNA






8. Neurons






9. Antifungal - act on microtubules






10. In the nucleus after transcitpion and only processed RNA is transporte out of the nucleus






11. Blocks denovo purine synthesis






12. Vimentin - desmin - cytockeratin - glial fibrillary acid proteins - neurofilaments






13. Prokaryotic only. Degrades RNA primer and fills in the gap with DNA (5 prime to 3 prime exonuclease)






14. Alpha 1 antitrypisn






15. Connective tissue






16. Neurons - skeletal - and cardiac muscle - RBCs






17. Checkpoints control transition between phases of cell cycle. regulated by cyclins - CDKs and tumor suppressors. Mitosis (shortest phse)






18. Inhibits the atpase which increases intracellular sodium which increases intracellular calcium increases cardiaccontractility






19. Anti cancer - act on microtubules






20. Y shaped region along DNA template where leading and lagging strands are syntehsized






21. Cilia - glagella - mitotic spindle - neurons - centrioles






22. Change resulting in early stop codon






23. One codon AUG






24. The 5prime end (energy for the bond)






25. Site where RNA polymerase and multiple other transciption factors bind to DNA upstream from gene locus (AT rich upstream sequence with TATA and CAAT boxes)






26. Inhibits 50S peptidyl transferase






27. Each codon specifies only 1 amino acid






28. Genetic bone disorder (brittle bone disease) type 1 colalgen - fractures (during birth) 2) Blue sclerae 3) hearing loss 4) dental imperfections 1:10000 may be confused with child abuse






29. Negatively charged DNA loops twice around histone octamers create a nucloesome bead.






30. Inhibits by binding to the potassium side






31. 1) primary transcript combines with snRNPs and other proteins to form spliceosome 2) lariat shaped intermediate is generated 3) Lariat is removed and released to precisely join 2 exons






32. Base + ribose






33. Hydroxy proline and hydroxylysine






34. Methyl THYmine has a meTHYl






35. Stretch of DNA that alters gene expression by binding transcription factors






36. Tansport cellular cargo toward opposite ends of microtubule tracks






37. Base+ribose+phosphate linked by a phosphodiester bond






38. 1 RNA polymerase (multisubunite complex) makes all 3 kinds of RNA






39. Ketone






40. DNA And RNA synthesized in the 5-3 direction






41. Codes for formyl methionine (f - Met)






42. Three amino acids necessary for purine synthesis= glutamine - aspartate and glycine






43. Even 40S 60S =80S






44. Uracil






45. 3 sodium out for 2 potassium in (nout - kin)takes 1 atp and the machine is phosphorylated during the machine cycle






46. Cylindrical structure composed of helical array of plymerized dimers of alpha and beta tubulin - flagella - cilia - mitotic spindle - grows slowly collapses quickly






47. The 3 prime end






48. No proofreading function but can initiate chains. RNA poymerase II opens DNA at promoter site






49. Site of secretory protiens (mucus secreting goblet cells and antibody secreting cells)






50. 9+2 arrangement of microtubules -