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First Aid: Biochemistry Molecular

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Immotile cilia due to a dyenin arm defect. Results in male nad female inferticility (sperm immotile) - bronchiectasis - and recurrent sinusisits - associated with situs inversus






2. Inhibits 50S peptidyl transferase






3. Inhibits bacterials dihydrofolate reducatese down thymine






4. Nucleotide excision repair - Base Excision repair - Mismath repair






5. Different exons can be combined to make nique protiens in different times






6. Aminoacyl - tRNA binds to A site 2) peptidyltransferase catalyzes peptide bond formation transfers growing polypeptie to amino acid in A site 3) ribosome advances 3 nucleotides toward the 3 prime end of RNA moving peptiydyl RNA to P site






7. Microvilli - muscle contraction - cytokinesis - adhering juntions






8. Changed aaconservative - new aa is similar in chemical structure






9. H1






10. Prophas - metaphase - anaphase telophase






11. Antigout - acts on mts






12. CCA AT 3 PRIME END






13. Three amino acids necessary for purine synthesis= glutamine - aspartate and glycine






14. Methyl THYmine has a meTHYl






15. Lysine/hydroxylysine and combines to form collagen






16. Cyclin depndent kinases; consituative and inactive






17. Never go to Go divide rapidly with short G1 bone marrow - gut epithelium - skin - hair follicles






18. Anit helminth - act on microtubules






19. Tansport cellular cargo toward opposite ends of microtubule tracks






20. Specific glycosylases recognize and remove damaged bases - AP endonuclease cuts DNA at pyrimidne site - empty sugar is removed and the gap is filled and resealed






21. 1) primary transcript combines with snRNPs and other proteins to form spliceosome 2) lariat shaped intermediate is generated 3) Lariat is removed and released to precisely join 2 exons






22. Activated by GTP hydrolosis initiation factors help assembel the 40 S ribosomal subunites with the initiatior tRNA and are released whent he mRNA and the ribosomal subunit assemple with the complex






23. No proofreading function but can initiate chains. RNA poymerase II opens DNA at promoter site






24. Site where negative regulators bind






25. Phosphorylation - glycosloation - hyderoxylation






26. 2 H bonds greater GC content greater melting point






27. P53 and RB normally inhibit g1 to S progression






28. G1 - S - G2 - Mitosis






29. Introns stay In the nucleus whereas EXons EXit and are EXpressed






30. A malfunction of mismatch repair (MUt L etc..)






31. Mutation in nucleotide excision repair Dry skin with melanoma and other cancers






32. Connective tissue






33. Prevents stranges from reannealing






34. Site of dteroid synthesis and detoxification of druigs and poisons (liver hepatocytes and steroid horomore adrenal cortex)






35. Cilia - glagella - mitotic spindle - neurons - centrioles






36. Accurate base pairing is required only in the first 2 nucleotide positions of an mRNA so codons differing ht e3rd wobble psoition may code for the same tRNA/amino acid code






37. Must be both activated and inactivated for cell cycle to progress






38. RER translation of collagen alpha chains (preprocollagen) usually Gly-X-Y






39. Specific endonucleases release the oligonucleotide containing damaged bases. DNA polymerase and logase fill and resealt eh gap






40. Particular sequnece in genomre where DNA replication begins. May be single (prokaryotes) or multiple (eukaryotes)






41. Made from orogate precuror with PRPP added later






42. HS1 - HSB - H2 - H4






43. Commonly results in dramatic decrease in amount of gene transcribed






44. Trimming removal of n or c terminal propeptides from zymogens to generate mature proteinds






45. Brings together 2 ends of DNA fragments no requirement for homology






46. Splicing out of introns






47. GTP






48. Regulatory proteins that control cell cycle events; phase specific; activated CDKs






49. AD and AR- associated iwth joint dislocation - berry aneurysms - organ rupture






50. Made from IMP precursor