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Test your basic knowledge |
First Aid: Biochemistry Molecular
Start Test
Study First
Subjects
:
health-sciences
,
first-aid
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Mutation in nucleotide excision repair Dry skin with melanoma and other cancers
Prokaryote RNA pol
transition
Xeroderma pigmentosum
Translocation
2. 1P (blocked by tetracycline)
Tumor Suppressors
origin of replication
Loading tRNA on to ribosome energy requirement
Steps in splicing
3. Negatively charged DNA loops twice around histone octamers create a nucloesome bead.
universal
Cell cycle
Alports syndrome
chromatin structure
4. Commonly results in dramatic decrease in amount of gene transcribed
The only histone not on the core
Promoter mutation
Pyrimidines
nonsense
5. Completed protein is released from ribosme through simple hydrolosis and dissociates
Steps in splicing
universal
Termination
Purines
6. ATP- AMP (2 phosphoanhydride bonds)
Plasma membrane composition
Kartageners syndrome
missense mutation
tRNA aminoacylation
7. More than 1 codon may code for the same amino acid
Single Strand DNA Repair types
Fluoroquinolones
degenerate or redundant
desmin
8. Elastase
What ties teh nucleosome together
Elastin is broken down by
Nucleotide excision repair
Step Three of RNA processing
9. Prokaryotic only. Elongates leading strand by adding deoxynucleotides to the 3prime end. Elongates laggin strand. 3 prime to 5 prime exonuclease activity
tRNA activation
Plasma membrane composition
transversion
DNA pol III
10. RER translation of collagen alpha chains (preprocollagen) usually Gly-X-Y
Collagedn synthesis where?
origin of replication
polyadenylation does/does not require a template
Digoxin (cardiac glycosides)
11. Cyclin depndent kinases; consituative and inactive
CDKs
Rough ER
Immunohistochemical stains vimentin
Aminoglycosides
12. Close to - far from or even within (in an intron) the gene whose expression it regulates
RNA polymerases in eukaryotes
Enhancers and silencer may be located_____
Clindamycin
Where do introns and exons stay
13. Particular sequnece in genomre where DNA replication begins. May be single (prokaryotes) or multiple (eukaryotes)
Proofreading function in eukaryotic RNA
nucleosid
origin of replication
Free ribosomes
14. No proofreading function but can initiate chains. RNA poymerase II opens DNA at promoter site
Nucleotide excision repair
Proofreading function in eukaryotic RNA
Cholchicine
Oubain
15. 3 H bonds
Post - translational modifications
C- G bond
mRNA start codons
trimethoprim
16. 3 sodium out for 2 potassium in (nout - kin)takes 1 atp and the machine is phosphorylated during the machine cycle
Sodium K ATPase
Digoxin (cardiac glycosides)
actin and myosin
Tetracyclines
17. Regulatory proteins that control cell cycle events; phase specific; activated CDKs
nucleosid
Ehlers Danlos
Cyclins
Immunohistochemical stains vimentin
18. Site where RNA polymerase and multiple other transciption factors bind to DNA upstream from gene locus (AT rich upstream sequence with TATA and CAAT boxes)
Labile
Rough ER
promoter
dyenin
19. Inhibits the atpase which increases intracellular sodium which increases intracellular calcium increases cardiaccontractility
DNA topoisomerases
Digoxin (cardiac glycosides)
Ehlers Danlos
tRNA
20. Has enough energy to created the peptide bond
the tRNA- amino acid bond
Introns
alpha amintin
unambiguous
21. The N to C
Protein synthesis is in which direction
Plasma membrane composition
Tropocollagen cross links between_____ to form____
Eukaroytes
22. Genetic bone disorder (brittle bone disease) type 1 colalgen - fractures (during birth) 2) Blue sclerae 3) hearing loss 4) dental imperfections 1:10000 may be confused with child abuse
Osteogenesis Imperfecta
Steps in splicing
Protein synthesis is in which direction
Methotrexate
23. You glyucosolate hte pro - alpha chain lysine resudens and form procollagen (triple helix of alpha chains)
Digoxin (cardiac glycosides)
Heterochromatin
Glycosolation
degenerate or redundant
24. Neuroglia
5FU
Functional organization of the gene
Methotrexate
GFAP
25. Epithelial cells
Base excision repair
Pyrimidines
cytokeratin
Tropocollagen cross links between_____ to form____
26. Change resulting in misreading of all nucleotides downstream - usually resulting in a truncated non functional protien
Kartageners syndrome
RNA polymerases in eukaryotes
frame shift
A- T
27. Site where negative regulators bind
Silencer
nucleotide
hydroxyurea
Cell cycle
28. Anti breast cancer - acts on mts
Paclitaxil
Nucleotide excision repair
Ribonucleotides are synthesized first and convertec to deoxyribonuclotides by
Osteogenesis Imperfecta
29. Methyl THYmine has a meTHYl
Immunohistochemical stains vimentin
Promoter mutation
Thymine has a
Alternate splicing
30. ATP
Paclitaxil
tRNA activation
Introns
Permanent cells
31. G1 - S - G2 - Mitosis
Cell cycle order
Exons
pyrimadines
Common amino acids in elastin
32. Ketone
Protein synthesis initiation
Translocation
Promoter mutation
Guanine has a
33. Microtubule polymerization defect resulting in lowered phagocytosis. results in recurrent pyogenic infections - partial albinism and peripheral neuropathy
nucleotide
alpha amintin
Chediak Higashi syndrome
CDKs
34. AUG inAUGurates protein synthesis
mRNA start codons
Fluoroquinolones
Excocytosis of collagen
Which is the most and least abundant type of RNA
35. Base + ribose
Promoter mutation
Which is the most and least abundant type of RNA
desmin
nucleosid
36. Made from orogate precuror with PRPP added later
5FU
pyrimadines
Hereditary non polyposis colorectal cancer
Sodium K ATPase
37. Trimming removal of n or c terminal propeptides from zymogens to generate mature proteinds
Smooth ER
Post - translational modifications
6MP
Hereditary non polyposis colorectal cancer
38. Substituting a pyramidine for a pyrimadine
Tumor Suppressors
DNA/RNA/Protein syntesis direction
transition
Functional organization of the gene
39. Capping on 5 prime end (7 methylguanosine) -
Step one of RNA processing
Protein synthesis is in which direction
DNA ligase
Excocytosis of collagen
40. AD and AR- associated iwth joint dislocation - berry aneurysms - organ rupture
Associations of Ehlers Danlos
nucleotide
Which end of the nucleotide has the triphosphate
polyadenylation does/does not require a template
41. Bm - kidney - ears and eyes
commaless - non - overlapping
Immunohistochemical stains vimentin
Glycosolation
Type IV collagen is an important structural component of...
42. Read froma fixed starting point as a continous sequenecs of bases
Guanine has a
promoter
Translocation
commaless - non - overlapping
43. Faulty collagen synthesis causing 1) hyperextensible skin 2) tendency to bleed 3) hypermobile joints
Silencer
Thymine has a
Hydroxylation of which amino acids are attached to Glycine to form collagen
Ehlers Danlos
44. Vimentin - desmin - cytockeratin - glial fibrillary acid proteins - neurofilaments
Tetracyclines
intermediate filaments
Alports syndrome
DNA/RNA/Protein syntesis direction
45. Each codon specifies only 1 amino acid
Labile
CDKs
unambiguous
Elastin is broken down by
46. Unattached to any membrane; site of cytosolic and organeller prtoeins
histone octamer names
Free ribosomes
GFAP
Elastase is inhibited by
47. Be So Totatally Cool Read Books (bOne - CarTWOlage - Threeticular - Type IV under the floor)
Tropocollagen cross links between_____ to form____
Protein synthesis is in which direction
Collagen
Pyrimidines
48. Change resulting in early stop codon
Glycosolation
nonsense
microtubule
single stranded binding proteinds
49. Hydroxy proline and hydroxylysine
Immunohistochemical stains vimentin
Mismatch repair
capped and tail transcript is called
Hydroxylation of which amino acids are attached to Glycine to form collagen
50. Inhibit DNA gyrase (specific prokaryotic topoisomerase)
DNA pol I
actin and myosin
DNA/RNA/Protein syntesis direction
Fluoroquinolones