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Test your basic knowledge |
First Aid: Biochemistry Molecular
Start Test
Study First
Subjects
:
health-sciences
,
first-aid
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Faulty collagen synthesis causing 1) hyperextensible skin 2) tendency to bleed 3) hypermobile joints
Cell cycle
Promoter mutation
Enhancer
Ehlers Danlos
2. G1 - S - G2 - Mitosis
DNA pol I
Cell cycle order
DNA topoisomerases
Elastase is inhibited by
3. Site where RNA polymerase and multiple other transciption factors bind to DNA upstream from gene locus (AT rich upstream sequence with TATA and CAAT boxes)
Paclitaxil
Cyclins
promoter
hydroxyurea
4. Cleave terminal regions of procollagen to transform into insoluable tropocolagen
the tRNA- amino acid bond
Elastase is inhibited by
Outside the cell what processing must be done in procolalgen
Initial transcript without processing is known as
5. Ribonucleotide reductase
commaless - non - overlapping
tRNA activation
Ribonucleotides are synthesized first and convertec to deoxyribonuclotides by
A- T
6. Antifungal - act on microtubules
Cyclins
Which is the most and least abundant type of RNA
Griseofulvin
DNA pol III
7. 4 high enrgy bonds
tRNA aminoacylation
Total energy expenditure requirement for translocation
Deamination of cytosine makes
Xeroderma pigmentosum
8. Cylindrical structure composed of helical array of plymerized dimers of alpha and beta tubulin - flagella - cilia - mitotic spindle - grows slowly collapses quickly
Initial transcript without processing is known as
microtubule
Common amino acids in elastin
Alternate splicing
9. Y shaped region along DNA template where leading and lagging strands are syntehsized
DNA ligase
Higher the cholesterol or long saturated fatty acid content
Replication fork
Permanent cells
10. Condensed - transciptionally inactive HC- Highly condensed
Oubain
Outside the cell what processing must be done in procolalgen
mRNA start codons
Heterochromatin
11. Prophas - metaphase - anaphase telophase
Order of mitosis
Common amino acids in elastin
Step Three of RNA processing
Axonemal dyenin
12. Does not
DNA ligase
Higher the cholesterol or long saturated fatty acid content
polyadenylation does/does not require a template
Going APE
13. Specific endonucleases release the oligonucleotide containing damaged bases. DNA polymerase and logase fill and resealt eh gap
commaless - non - overlapping
nucleosid
Nucleotide excision repair
Prokaryote RNA pol
14. 1P (blocked by tetracycline)
Heterochromatin
Loading tRNA on to ribosome energy requirement
transition
Protein synthesis initiation
15. Create a nick in the helix to relieve supercoils created during replication
DNA topoisomerases
Step one of RNA processing
CDKs
Hydroxylation of which amino acids are attached to Glycine to form collagen
16. DNA And RNA synthesized in the 5-3 direction
AUG codes For what in prokaryotes
Elastin is broken down by
DNA/RNA/Protein syntesis direction
What does the hydroxylation of proline and lysine require
17. One codon AUG
methionine is only encoded by
Base excision repair
Cyclin - CDK
Heterochromatin
18. Capping on 5 prime end (7 methylguanosine) -
hydroxyurea
Step one of RNA processing
Exons
Elastin
19. Base + ribose
tRNA aminoacylation
Aminoacylt - tRNA synthetase
nucleosid
Silencer
20. Mutation in nucleotide excision repair Dry skin with melanoma and other cancers
frame shift
Xeroderma pigmentosum
Chediak Higashi syndrome
mRNA start codons
21. Anti breast cancer - acts on mts
Paclitaxil
Step one of RNA processing
DNA/RNA/Protein syntesis direction
Gag on pure gold
22. Inhibit DNA gyrase (specific prokaryotic topoisomerase)
Chediak Higashi syndrome
tRNA aminoacylation
Methotrexate
Fluoroquinolones
23. Asymmetric fluid bilayer - contains - cholesterol - phospholipids - sphingoplipids - glycolipids - and protiends
Elastin is broken down by
Plasma membrane composition
Introns
kinesin
24. Base+ribose+phosphate linked by a phosphodiester bond
nucleotide
pyrimadines
Translocation
Guanine has a
25. Prevents stranges from reannealing
Promoter mutation
Proofreading function in eukaryotic RNA
single stranded binding proteinds
intermediate filaments
26. AUG inAUGurates protein synthesis
mRNA start codons
Mebendazole/thiabendazole
Associations of Ehlers Danlos
actin and myosin
27. Tansport cellular cargo toward opposite ends of microtubule tracks
Enhancers and silencer may be located_____
Protein synthesis initiation
kinesin
Molecular motor protiesn
28. Particular sequnece in genomre where DNA replication begins. May be single (prokaryotes) or multiple (eukaryotes)
helicase
Elongation
Methotrexate
origin of replication
29. Type III
What type of collagen is most affected in Ehlers Danlos
Base excision repair
Enhancer
Cyclin - CDK
30. UGA - UAG - UAA
Elastin is broken down by
methionine is only encoded by
mRNA stop codons
AUG codes For what in prokaryotes
31. Commonly results in dramatic decrease in amount of gene transcribed
kinesin
Promoter mutation
actin and myosin
Molecular motor protiesn
32. Same aa often base change in 3rd position of codon
Collagen
Chediak Higashi syndrome
DNA ligase
silent mutation
33. Ketone
chromatin structure
Which end of the tRNA is the amino acid bound to?
Guanine has a
Aminoacylt - tRNA synthetase
34. 75-90 nucleotides - 2ary structure cloverleaf form anticodon end is opposite 3 prime aminoacyl end
Steps in splicing
aminoacyl - tRNA synthetase and binding of charged tRNA to the codon
tRNA Structure
Higher the cholesterol or long saturated fatty acid content
35. Codes for formyl methionine (f - Met)
AUG codes For what in prokaryotes
Promoter mutation
6MP
Alports syndrome
36. Connective tissue
Immunohistochemical stains vimentin
Cholchicine
Replication fork
Step Three of RNA processing
37. Regulatory proteins that control cell cycle events; phase specific; activated CDKs
degenerate or redundant
Cyclins
GFAP
Order of mitosis
38. Genetic bone disorder (brittle bone disease) type 1 colalgen - fractures (during birth) 2) Blue sclerae 3) hearing loss 4) dental imperfections 1:10000 may be confused with child abuse
Purines
Which end of the tRNA is the amino acid bound to?
Osteogenesis Imperfecta
In eukaryotes the starting amino acid is...
39. Made from orogate precuror with PRPP added later
RNA processing in eukaryotes occurs
pyrimadines
Excocytosis of collagen
RNA polymerases in eukaryotes
40. Microtubule polymerization defect resulting in lowered phagocytosis. results in recurrent pyogenic infections - partial albinism and peripheral neuropathy
Protein synthesis initiation
Translocation
helicase
Chediak Higashi syndrome
41. Activated by GTP hydrolosis initiation factors help assembel the 40 S ribosomal subunites with the initiatior tRNA and are released whent he mRNA and the ribosomal subunit assemple with the complex
Protein synthesis initiation
Termination
DNA ligase
DNA/RNA/Protein syntesis direction
42. Phosphorylation - glycosloation - hyderoxylation
Covalent alterations
mRNA stop codons
Double Strand DNA repair
RNA processing in eukaryotes occurs
43. Change resulting in early stop codon
Ribonucleotides are synthesized first and convertec to deoxyribonuclotides by
Ehlers Danlos
Euchromatin
nonsense
44. Has enough energy to created the peptide bond
tRNA aminoacylation
the tRNA- amino acid bond
aminoacyl - tRNA synthetase and binding of charged tRNA to the codon
Kartageners syndrome
45. Checkpoints control transition between phases of cell cycle. regulated by cyclins - CDKs and tumor suppressors. Mitosis (shortest phse)
Elongation
What type of collagen is most affected in Ehlers Danlos
GFAP
Cell cycle
46. Neurons - skeletal - and cardiac muscle - RBCs
cytokeratin
Example of permanent cells
Step Three of RNA processing
the tRNA- amino acid bond
47. Remain in G0 regenerate from stem cells
Replication fork
Aminoacylt - tRNA synthetase
Permanent cells
DNA ligase
48. HS1 - HSB - H2 - H4
histone octamer names
microtubule
Replication fork
DNA pol III
49. Neuroglia
Elastin
GFAP
Where do introns and exons stay
microtubule
50. Trimming removal of n or c terminal propeptides from zymogens to generate mature proteinds
Post - translational modifications
mRNA is syntehsized in which direction?
Clindamycin
Exons