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First Aid: Biochemistry Molecular

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Three amino acids necessary for purine synthesis= glutamine - aspartate and glycine






2. Muscle






3. 2 H bonds greater GC content greater melting point






4. Accurate base pairing is required only in the first 2 nucleotide positions of an mRNA so codons differing ht e3rd wobble psoition may code for the same tRNA/amino acid code






5. Different exons can be combined to make nique protiens in different times






6. Condensed - transciptionally inactive HC- Highly condensed






7. Asymmetric fluid bilayer - contains - cholesterol - phospholipids - sphingoplipids - glycolipids - and protiends






8. Poly adenylation






9. Alpha 1 antitrypisn






10. Even 40S 60S =80S






11. Type III






12. Attachment of ubiquitin to defective proteinds to tag them for breakdown






13. P53 and RB normally inhibit g1 to S progression






14. Neurons - skeletal - and cardiac muscle - RBCs






15. Enter G1 from G0 when stimulated Hepatocytes/lymphocytes






16. Lysine/hydroxylysine and combines to form collagen






17. Remain in G0 regenerate from stem cells






18. Close to - far from or even within (in an intron) the gene whose expression it regulates






19. Inhibit formation of the initation complex and cause misreading of mRNA






20. Promoter - enhancer - promoter - TATA- transcription initiation site - coding region (including exons and introns) and then the AATAAA






21. Makes an RNA primer on which DNA polymerase II can initiate replication






22. Ribonucleotide reductase






23. Hn RNA






24. Bind 30S subunit preventing attachment of aminoacyl - tRNA






25. RNA polymerase I makes rRNA - RNA pol II makes mRNA - RNA pol III makes tRNA






26. Binds 50S blocking translocation






27. Never go to Go divide rapidly with short G1 bone marrow - gut epithelium - skin - hair follicles






28. Specific endonucleases release the oligonucleotide containing damaged bases. DNA polymerase and logase fill and resealt eh gap






29. Non homologous end joining






30. Capping on 5 prime end (7 methylguanosine) -






31. Brings together 2 ends of DNA fragments no requirement for homology






32. Neurons






33. Specific glycosylases recognize and remove damaged bases - AP endonuclease cuts DNA at pyrimidne site - empty sugar is removed and the gap is filled and resealed






34. Read froma fixed starting point as a continous sequenecs of bases






35. Blocks denovo purine synthesis






36. Microtubule polymerization defect resulting in lowered phagocytosis. results in recurrent pyogenic infections - partial albinism and peripheral neuropathy






37. More than 1 codon may code for the same amino acid






38. The 3 prime hydroxyl of the nascent chain is the target






39. Tansport cellular cargo toward opposite ends of microtubule tracks






40. Faulty collagen synthesis causing 1) hyperextensible skin 2) tendency to bleed 3) hypermobile joints






41. Stretch of DNA that alters gene expression by binding transcription factors






42. 9+2 arrangement of microtubules -






43. Antifungal - act on microtubules






44. Prevents stranges from reannealing






45. Inhibit DNA gyrase (specific prokaryotic topoisomerase)






46. Substituting a pyramidine for a pyrimadine






47. HS1 - HSB - H2 - H4






48. Genetic code is conserved throughout evolution






49. RER translation of collagen alpha chains (preprocollagen) usually Gly-X-Y






50. Same aa often base change in 3rd position of codon






Can you answer 50 questions in 15 minutes?



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