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First Aid: Biochemistry Molecular

Subjects : health-sciences, first-aid

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Create a nick in the helix to relieve supercoils created during replication
DNA topoisomerases
Post - translational modifications
dyenin
Axonemal dyenin

2. ATP- AMP (2 phosphoanhydride bonds)
Mismatch repair
Where do introns and exons stay
tRNA aminoacylation
Excocytosis of collagen

3. H1
Mismatch repair
What does the hydroxylation of proline and lysine require
The only histone not on the core
alpha amintin

4. Neurons
Initial transcript without processing is known as
Kartageners syndrome
Alports syndrome
Neurofilaments

5. Particular sequnece in genomre where DNA replication begins. May be single (prokaryotes) or multiple (eukaryotes)
Functional organization of the gene
Guanine has a
DNA/RNA/Protein syntesis direction
origin of replication

6. Prophas - metaphase - anaphase telophase
Tumor Suppressors
Covalent alterations
transversion
Order of mitosis

7. Cilia - glagella - mitotic spindle - neurons - centrioles
Griseofulvin
Pyrimidines
microtubule
Neurofilaments

8. Even 40S 60S =80S
Which end of the nucleotide has the triphosphate
Eukaroytes
Neurofilaments
tRNA

9. Elastase
Elastase is inhibited by
Elastin is broken down by
A- T
Alternate splicing

10. No proofreading function but can initiate chains. RNA poymerase II opens DNA at promoter site
Silencer
Cell cycle
Proofreading function in eukaryotic RNA
methionine is only encoded by

11. Intervening noncoding segments of DNA
Chediak Higashi syndrome
Fluoroquinolones
Introns
Prokaryotes

12. Responsible for the accuracy of amino acid selection
Aminoacylt - tRNA synthetase
Higher the cholesterol or long saturated fatty acid content
Type IV collagen is an important structural component of...
aminoacyl - tRNA synthetase and binding of charged tRNA to the codon

13. CUT 1 ring Cut the Py
universal
Post - translational modifications
Silencer
Pyrimidines

14. Antigout - acts on mts
Nucleotide excision repair
Introns
Cholchicine
tRNA Structure

15. Anit helminth - act on microtubules
Vincristine/Vinblastine
Termination
Digoxin (cardiac glycosides)
Mebendazole/thiabendazole

16. In the nucleus after transcitpion and only processed RNA is transporte out of the nucleus
Enhancers and silencer may be located_____
Cell cycle order
commaless - non - overlapping
RNA processing in eukaryotes occurs

17. Makes an RNA primer on which DNA polymerase II can initiate replication
Primase
Clindamycin
Which is the most and least abundant type of RNA
Proofreading function in eukaryotic RNA

18. Unwinds DNA template at replication fork
DNA ligase
Outside the cell what processing must be done in procolalgen
missense mutation
helicase

19. Prokaryotic only. Degrades RNA primer and fills in the gap with DNA (5 prime to 3 prime exonuclease)
DNA pol I
mRNA start codons
Base excision repair
Step one of RNA processing

20. 1) primary transcript combines with snRNPs and other proteins to form spliceosome 2) lariat shaped intermediate is generated 3) Lariat is removed and released to precisely join 2 exons
In eukaryotes the starting amino acid is...
Steps in splicing
Prokaryote RNA pol
Termination

21. Stretch of DNA that alters gene expression by binding transcription factors
Eukaroytes
Which is the most and least abundant type of RNA
DNA pol I
Enhancer

22. Microvilli - muscle contraction - cytokinesis - adhering juntions
Elastin
Aminoacylt - tRNA synthetase
actin and myosin
Ehlers Danlos

23. Splicing out of introns
tRNA Structure
Step Three of RNA processing
promoter
Exons

24. A site - incoming aminoacyl tRNA - Psite accomodates growing Peptide - E site holds EmplytRNA as it exits
promoter
Going APE
capped and tail transcript is called
Free ribosomes

25. Blocks denovo purine synthesis
Cyclins
Methotrexate
6MP
Introns

26. Activated by GTP hydrolosis initiation factors help assembel the 40 S ribosomal subunites with the initiatior tRNA and are released whent he mRNA and the ribosomal subunit assemple with the complex
Promoter mutation
Protein synthesis initiation
tRNA aminoacylation
kinesin

27. Neuroglia
Type IV collagen is an important structural component of...
GFAP
Purines
Methotrexate

28. Changed aaconservative - new aa is similar in chemical structure
Prokaryote RNA pol
Covalent alterations
Aminoglycosides
missense mutation

29. Neurons - skeletal - and cardiac muscle - RBCs
Which end of the tRNA is the amino acid bound to?
Paclitaxil
Example of permanent cells
Total energy expenditure requirement for translocation

30. P53 and RB normally inhibit g1 to S progression
frame shift
transition
Tumor Suppressors
In eukaryotes the starting amino acid is...

31. Close to - far from or even within (in an intron) the gene whose expression it regulates
Alports syndrome
cytokeratin
Enhancers and silencer may be located_____
DNA pol I

32. (A - G) 2 rings Pure As Gold
Purines
Which end of the tRNA is the amino acid bound to?
Neurofilaments
Stable (quiescent)

33. Three amino acids necessary for purine synthesis= glutamine - aspartate and glycine
Functional organization of the gene
Gag on pure gold
DNA pol III
Example of permanent cells

34. Base + ribose
Associations of Ehlers Danlos
Methotrexate
Elastin
nucleosid

35. Enter G1 from G0 when stimulated Hepatocytes/lymphocytes
Hereditary non polyposis colorectal cancer
Stable (quiescent)
nucleosid
Promoter mutation

36. Inhbits RNA pol II (found in death cap mushrooms)
Osteogenesis Imperfecta
Elongation
alpha amintin
Paclitaxil

37. Remain in G0 regenerate from stem cells
microtubule
Termination
Which is the most and least abundant type of RNA
Permanent cells

38. You glyucosolate hte pro - alpha chain lysine resudens and form procollagen (triple helix of alpha chains)
Example of permanent cells
Glycosolation
Hereditary non polyposis colorectal cancer
nucleosid

39. Bind 30S subunit preventing attachment of aminoacyl - tRNA
Gag on pure gold
step two of RNA processing
DNA pol III
Tetracyclines

40. Specific glycosylases recognize and remove damaged bases - AP endonuclease cuts DNA at pyrimidne site - empty sugar is removed and the gap is filled and resealed
Base excision repair
In eukaryotes the starting amino acid is...
aminoacyl - tRNA synthetase and binding of charged tRNA to the codon
Deamination of cytosine makes

41. Faulty collagen synthesis causing 1) hyperextensible skin 2) tendency to bleed 3) hypermobile joints
Cell cycle
The only histone not on the core
Chloramphenicol
Ehlers Danlos

42. Type III
Molecular motor protiesn
Alports syndrome
What type of collagen is most affected in Ehlers Danlos
Non homologous end joining

43. Inhibit DNA gyrase (specific prokaryotic topoisomerase)
Collagedn synthesis where?
Sodium K ATPase
missense mutation
Fluoroquinolones

44. Different exons can be combined to make nique protiens in different times
What does the hydroxylation of proline and lysine require
Alternate splicing
Proofreading function in eukaryotic RNA
Proteosomal degradation

45. Non homologous end joining
Silencer
Prokaryote RNA pol
Double Strand DNA repair
Guanine has a

46. Site of dteroid synthesis and detoxification of druigs and poisons (liver hepatocytes and steroid horomore adrenal cortex)
Paclitaxil
Kartageners syndrome
Pyrimidines
Smooth ER

47. Checkpoints control transition between phases of cell cycle. regulated by cyclins - CDKs and tumor suppressors. Mitosis (shortest phse)
Cell cycle
Methotrexate
Which is the most and least abundant type of RNA
Which end of a growing DNA strand is the target

48. Made from IMP precursor
Rough ER
purines
In eukaryotes the starting amino acid is...
What does the hydroxylation of proline and lysine require

49. Prevents stranges from reannealing
Excocytosis of collagen
Initial transcript without processing is known as
single stranded binding proteinds
Plasma membrane composition

50. Made from orogate precuror with PRPP added later
pyrimadines
Digoxin (cardiac glycosides)
Pyrimidines
histone octamer names