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Test your basic knowledge |
First Aid: Biochemistry Molecular
Start Test
Study First
Subjects
:
health-sciences
,
first-aid
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Inhibits thymidylate synthase down thymine
Neurofilaments
5FU
Associations of Ehlers Danlos
Elastin
2. Inhibits the atpase which increases intracellular sodium which increases intracellular calcium increases cardiaccontractility
Hydroxylation of which amino acids are attached to Glycine to form collagen
Digoxin (cardiac glycosides)
Primase
Xeroderma pigmentosum
3. Neuroglia
Cholchicine
single stranded binding proteinds
Elastin
GFAP
4. A malfunction of mismatch repair (MUt L etc..)
Purines
helicase
Hereditary non polyposis colorectal cancer
missense mutation
5. Immotile cilia due to a dyenin arm defect. Results in male nad female inferticility (sperm immotile) - bronchiectasis - and recurrent sinusisits - associated with situs inversus
Proteosomal degradation
Kartageners syndrome
Enhancer
step two of RNA processing
6. Less condensed - transciptionally active=eu truly transcobed
Ehlers Danlos
Chloramphenicol
Euchromatin
Tumor Suppressors
7. Intervening noncoding segments of DNA
cytokeratin
Introns
the tRNA- amino acid bond
Euchromatin
8. The 3 prime hydroxyl of the nascent chain is the target
Purines
aminoacyl - tRNA synthetase and binding of charged tRNA to the codon
Tumor Suppressors
Which end of a growing DNA strand is the target
9. Methionine - which may be removed before translation is completed
Outside the cell what processing must be done in procolalgen
Proteosomal degradation
desmin
In eukaryotes the starting amino acid is...
10. Site where negative regulators bind
Non homologous end joining
Heterochromatin
Silencer
Translocation
11. RER translation of collagen alpha chains (preprocollagen) usually Gly-X-Y
Collagedn synthesis where?
Elastin is broken down by
pyrimadines
Macrolides
12. Unwinds DNA template at replication fork
helicase
Protein synthesis is in which direction
Mebendazole/thiabendazole
Post - translational modifications
13. 1) primary transcript combines with snRNPs and other proteins to form spliceosome 2) lariat shaped intermediate is generated 3) Lariat is removed and released to precisely join 2 exons
Enhancers and silencer may be located_____
Steps in splicing
Type IV collagen is an important structural component of...
Nucleotide excision repair
14. Microtubule polymerization defect resulting in lowered phagocytosis. results in recurrent pyogenic infections - partial albinism and peripheral neuropathy
Exons
actin and myosin
Tropocollagen cross links between_____ to form____
Chediak Higashi syndrome
15. Activated by GTP hydrolosis initiation factors help assembel the 40 S ribosomal subunites with the initiatior tRNA and are released whent he mRNA and the ribosomal subunit assemple with the complex
Tetracyclines
Smooth ER
Protein synthesis initiation
single stranded binding proteinds
16. UGA - UAG - UAA
Cilia structure
Euchromatin
mRNA stop codons
Free ribosomes
17. Responsible for the accuracy of amino acid selection
Collagen
Mismatch repair
tRNA aminoacylation
aminoacyl - tRNA synthetase and binding of charged tRNA to the codon
18. Type III
What type of collagen is most affected in Ehlers Danlos
step two of RNA processing
Proteosomal degradation
tRNA gripping and going places
19. Bind 30S subunit preventing attachment of aminoacyl - tRNA
DNA ligase
the tRNA- amino acid bond
Labile
Tetracyclines
20. Non homologous end joining
Double Strand DNA repair
Proteosomal degradation
Translocation
capped and tail transcript is called
21. Particular sequnece in genomre where DNA replication begins. May be single (prokaryotes) or multiple (eukaryotes)
chromatin structure
origin of replication
Which is the most and least abundant type of RNA
step two of RNA processing
22. Even 40S 60S =80S
Eukaroytes
Elastin
Primase
Hereditary non polyposis colorectal cancer
23. Condensed - transciptionally inactive HC- Highly condensed
Heterochromatin
polyadenylation does/does not require a template
purines
Double Strand DNA repair
24. RNA polymerase I makes rRNA - RNA pol II makes mRNA - RNA pol III makes tRNA
Promoter mutation
Oubain
RNA polymerases in eukaryotes
Osteogenesis Imperfecta
25. A site - incoming aminoacyl tRNA - Psite accomodates growing Peptide - E site holds EmplytRNA as it exits
Going APE
Ribonucleotides are synthesized first and convertec to deoxyribonuclotides by
DNA ligase
degenerate or redundant
26. Prokaryotic only. Elongates leading strand by adding deoxynucleotides to the 3prime end. Elongates laggin strand. 3 prime to 5 prime exonuclease activity
Step one of RNA processing
Which end of a growing DNA strand is the target
DNA pol III
What does the hydroxylation of proline and lysine require
27. Changed aaconservative - new aa is similar in chemical structure
DNA pol III
missense mutation
Tetracyclines
the tRNA- amino acid bond
28. Change resulting in early stop codon
Cyclin - CDK
Glycosolation
nonsense
aminoacyl - tRNA synthetase and binding of charged tRNA to the codon
29. In the nucleus after transcitpion and only processed RNA is transporte out of the nucleus
RNA processing in eukaryotes occurs
Nucleotide excision repair
Non homologous end joining
RNA polymerases in eukaryotes
30. Inhibit formation of the initation complex and cause misreading of mRNA
purines
Aminoglycosides
Plasma membrane composition
Purines
31. Promoter - enhancer - promoter - TATA- transcription initiation site - coding region (including exons and introns) and then the AATAAA
Tetracyclines
Clindamycin
Functional organization of the gene
frame shift
32. Commonly results in dramatic decrease in amount of gene transcribed
Promoter mutation
Osteogenesis Imperfecta
cytokeratin
C- G bond
33. Genetic bone disorder (brittle bone disease) type 1 colalgen - fractures (during birth) 2) Blue sclerae 3) hearing loss 4) dental imperfections 1:10000 may be confused with child abuse
The only histone not on the core
Osteogenesis Imperfecta
Collagedn synthesis where?
Termination
34. G1 - S - G2 - Mitosis
Immunohistochemical stains vimentin
dyenin
CDKs
Cell cycle order
35. The 3 prime end
Digoxin (cardiac glycosides)
Loading tRNA on to ribosome energy requirement
Promoter mutation
Which end of the tRNA is the amino acid bound to?
36. Same aa often base change in 3rd position of codon
Loading tRNA on to ribosome energy requirement
Immunohistochemical stains vimentin
silent mutation
DNA ligase
37. Prevents stranges from reannealing
transversion
Vincristine/Vinblastine
Paclitaxil
single stranded binding proteinds
38. H1 string
Osteogenesis Imperfecta
What ties teh nucleosome together
Prokaryote RNA pol
DNA topoisomerases
39. Must be both activated and inactivated for cell cycle to progress
trimethoprim
Cyclin - CDK
Heterochromatin
Griseofulvin
40. Be So Totatally Cool Read Books (bOne - CarTWOlage - Threeticular - Type IV under the floor)
Loading tRNA on to ribosome energy requirement
Collagen
Higher the cholesterol or long saturated fatty acid content
transversion
41. The N to C
Termination
desmin
RNA polymerases in eukaryotes
Protein synthesis is in which direction
42. Unmethylated - newly synthesized string is recognized - mismatched nucleotides are removed and the gap is filled and resealed
What type of collagen is most affected in Ehlers Danlos
Ribonucleotides are synthesized first and convertec to deoxyribonuclotides by
Mismatch repair
kinesin
43. Cleave terminal regions of procollagen to transform into insoluable tropocolagen
Nucleotide excision repair
Enhancer
DNA topoisomerases
Outside the cell what processing must be done in procolalgen
44. 1P blocked by chloramphenicaol and macrolide
Translocation
Covalent alterations
hydroxyurea
Gag on pure gold
45. Regulatory proteins that control cell cycle events; phase specific; activated CDKs
Initial transcript without processing is known as
Cyclins
6MP
Introns
46. 1P (blocked by tetracycline)
Translocation
Loading tRNA on to ribosome energy requirement
commaless - non - overlapping
Collagen
47. Prokaryotic only. Degrades RNA primer and fills in the gap with DNA (5 prime to 3 prime exonuclease)
tRNA activation
Tumor Suppressors
DNA pol I
Smooth ER
48. 9+2 arrangement of microtubules -
pyrimadines
cytokeratin
Cilia structure
Cell cycle
49. Phosphorylation - glycosloation - hyderoxylation
Hydroxylation of which amino acids are attached to Glycine to form collagen
capped and tail transcript is called
Permanent cells
Covalent alterations
50. Specific endonucleases release the oligonucleotide containing damaged bases. DNA polymerase and logase fill and resealt eh gap
tRNA gripping and going places
Clindamycin
RNA polymerases in eukaryotes
Nucleotide excision repair