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Test your basic knowledge |
Hemeonc
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Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How does vWD cause elevated PTT?
Signs and sx of aplastic anemia
Factor V resistant to activated protein C's inhibition
Pyruvate kinase def - extravascular
VWF carries/protects factor VIII
2. anti - Ig antibody added to patients RBCs;
Polycythemia vera
Myelofibrosis (marow is crying being its fibrosed'
Direct coombs - agglutinate if RBCs are coated with Ig
CD15 and CD30 pos
3. What is the receptor for vWF
HIV or immunosupression
Gp1b
No antigen - both antibodies
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
4. What virus is associated with 50% of Hodgkin lymphoma
EBV
Cold - seen in CLL - mycoplasma pneumoniae infections or infectious mononucleosis
Blod - tissue - MACS
Multiple myeloma
5. Where are mast cells found
Anemia of chronic disease - Aplastic anemia - kidney disease
Burkitt lymphoma
Tissue
90% anearobically from glucose to lactate - 10% from HMP shunt
6. What are some causes of warm agglutinin autoimmune hemolytic anemia?
SLE - CLL - alpha methyldopa
Mantle cell lymphoma
TXA2 - dec blood flow - inc platelet aggregation
Factor V Leiden
7. Which pathway and factors are tested in the PTT test
Protoporphyrin
B12 in fatty acid pathways leads to subacute combined degeneration
Intrinsic - all factors except - VII - XIII
Down - down - up
8. Serum iron - transferrin - ferritin lab values for iron def anemia
CNS and testis
Down - up - down
Protoporphyrin (blood)
Spleen
9. drug that inhibits ADP induced expression of GpIIb/IIIa
Ticlopidine/clopidogrel
Hb Barts - gamma4 in defect in all 4 alpha genes
Gp1b
Produce antibody - lots of RER and golgi
10. What CD molecules are on RS cells
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
Lung disease - congenital heart diseaes - and high altitude
CD15 and CD30 pos
DDAVP (desmopressin) which releases stored vWF stored in endothelium
11. Wilm's tumor - RCC - HCC - hydronephrosis
5- FU - AZT - hydroxyurea
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Hodgkin
Multiple myeloma
12. What chromosomal translocation is associated with a better prognosis in All
IFN gama
Sickle cell anemia
T(12;21)
VWF and fibrinogen
13. What is the pathogenesis of TTP?
Bite cells and Heinz bodies
Inc large vWF multimers - inc platelet aggregation and thrombosis
MHC II and Fc receptors
Uroporphyrin (tea colored urine)
14. Where to T cells arise and mature - and migrate to...
Sideroblastic anemia
Bone marrow - thymus - blood (80% of circulating lymphos are T)
B12/folate def
Von Willebrand's disease
15. hypocellular bone marrown tih fatty infiltration
Aplastic anemia - pancytopenia
Her next Rh+ fetus
Splicing sites and promotor sequences
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
16. Schisotcyte - helmet cell
CD15 and CD30 pos
DIC - TTP/HUS - traumatic hemolysis
DNA synth impaired - maturation of nucleus delayed relative to maturation of cytoplasm
Low in CML
17. Deficiency in vWF
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18. Who has more severe disease - HbSS or HbSC
B6 therapy (pyrodixine)
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
HbSS
19. Plasma cell neoplasm
G6PD
Inc large vWF multimers - inc platelet aggregation and thrombosis
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Multiple myeloma
20. What does LEAD stand for in lead poisoning?
Follicular lymphoma - indolent course
DIC - TTP/HUS - traumatic hemolysis
Nl - up - nl
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
21. What is the most common nonhodgkin lymphoma
Porphyrias
Diffuse Large b cell lymphoma
Leukemoid reaction
No platelet clumping
22. What are the four levels of alpha thal?
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
Low in CML
Varying sizes
23. What does ADP do?
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Helps platelts adhere to endothelium
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
Hodgkin
24. What does STOP Making New Thrombi stand for
EBV
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
No lytic bone lesions in WM
25. Eosinophils are highly phagocytic For what kind of complex?
Antigen - antibody
Decrease EPO
ADP and Ca
VWF carries/protects factor VIII
26. What is the tx for aplastic anemia
40 to 75
PGI2 - NO inc blood flow - dec platelet aggregation
Uroporphyrin (tea colored urine)
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
27. What condition can result from treating AML M3 from the release of the Auer rods
DIC
Beta thal
Glycine and succinyl - coa
EBV
28. What are the etiologies of B12 def
Inappropriate absolute with inc RBCs and EPO
No lytic bone lesions in WM
Histaminase and arylsulfatase
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
29. What is a blast crisis
Inc serum iron - normal TIBC - inc ferratin
VWD
CML to AML or All
Dendritic cells?
30. universal recipient
AB - no antibodies
CML to AML or All
MGUS - monoclonal gammopathy of undetermined significance
Indirect coombs - agglutinate if serum anti RBC surface Ig
31. Which pathway and factorrs are tested by the PT coag test
1 to 6
Extrinsic - I - II - V - VII and X
8-10 days
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
32. Defect in proteins interacting with RBC membrane skeleton and plasma membrane
HyperCalcemia - Renal insuff - Anemia - Bone lytic lesions/Back pain
Hodgkin
Hereditary spherocytosis
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
33. What virus can cause an aplastic crisis in pts with HS?
Abciximab
B12/folate def
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Parvovirus
34. Which lymphoma is characterized by localized involvement with a single group of nodes and mediastinal lymphadenopathy
Inc vasodiltion - inc perm - inc pain
Hodgkin
Blistering cutaneous photosens - most common porphyria
G6PD
35. what proteins can be defective in HS?
Down - up - down
No lytic bone lesions in WM
Ankryin - band 4.1 or spectrin
8-10 days
36. What does ectopic EPO produce
Inappropriate absolute with inc RBCs and EPO
Aspirin
GpIIb/IIIa
Petechiae
37. What is the are the presenting symptoms of lead poisoning in kids and adults
Porphobilinogen - delta ALA - uroporphyrin
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
38. tennis rackets on EM
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT
Birbeck granules
Rhogam - Rh antigen immunoglobulin
39. bcl -2 t(14;18) adults
VWD
Folate def
Follicular lymphoma - indolent course
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
40. What substances are released in mast cell degranulation
Def in factor IX
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Histamine - heparin - and eosinohil chemotactic factors
Parvovirus
41. What is the difference of presentation of Burkitt in Africa vs the United States
PENTAD: neurologic sx - renal sx - fever - thrombocytopenia - MAHA
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
Africa = Jaw lesion - US = pelvis or abdomen
42. t(15;17)
Cromolyn sodium
M3 AML (acute promyelocytic leukemia)
B cells
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
43. What is the characteristic histologic finding in Hodgkin Lymphoma
Reed - sternberg cells
Hydroxyurea - bone marrow transplant
Low in CML
Inc RBC - dec O2 sat - inc EPO
44. What role does antithrombin play?
Inactivates it
Incactivates II - VII - IX - X - XI - XII
Hairy cell leukemia
Cromolyn sodium
45. What is the treatment for acute intermittent porphyria
Glucose and heme - which inhibit ALA synthase
Paraprotein spike - monoclonal protein
Varying sizes
Hereditary spherocytosis
46. What is the pathogenesis of ACD?
Prothrombin gene mutation
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Sickle cell anemia
Fibrinogen bind GpIIb/IIIa and links platelts
47. Drug that inhbits the GpIIb/IIIa directly
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
Abciximab
48. What reveresible things can a sideroblastic anemia
Lead - and EtOH
Prothrombin gene mutation
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
Marrow - marrow - follicles of lymph nodes - white pulp of spleen (unencapsulated lymphoid tissue)
49. Which drugs can cause macrocytic anemia?
5- FU - AZT - hydroxyurea
Bite cells and Heinz bodies
Ankryin - band 4.1 or spectrin
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
50. What begins the extrinsic pathway?
Schistocytes - helmet cells
Tissue factor converst the VII and VIIa
G6PD
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
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