SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
Hemeonc
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How do platelet disorders present?
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
SLE - CLL - alpha methyldopa
Inappropriate absolute with inc RBCs and EPO
Histamine - heparin - and eosinohil chemotactic factors
2. What is the effect of ACE on bradykinin
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
Exposed collagen upon endothelial damage
HbSS
Inactivates it
3. What percentage of WBCs are basophils - and What is found in their basophilic granules?
Ringed sideronblasts with iron laden mitochondria
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
4. Spherocyte
Inc vasodiltion - inc perm - inc pain
HbSS
Hereditary spherocytosis - autoimmune hemolysis
Heinz bodies - seen in alpha thal and G6PD
5. What is the therapy for the M3 variant?
Down - down - up
Inc RBC - dec O2 sat - inc EPO
All trans retinoic acid
Plasma cell
6. What do you see a starry sky appearance in Burkitt
Sheets of lymphocytes interspersed with macs
...
Porphobilinogen - delta ALA - uroporphyrin
DIC - TTP/HUS - traumatic hemolysis
7. Which pathway and factorrs are tested by the PT coag test
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT
Extrinsic - I - II - V - VII and X
PGI2 - NO inc blood flow - dec platelet aggregation
Lacunar in nodular sclerosing variant
8. What are the presenting symptoms of porphyria cutanea tarda
Mantle cell lymphoma
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
Abciximab
Blistering cutaneous photosens - most common porphyria
9. When is the peak incidence for nonHod lymphoma
VWF and fibrinogen
Epoxide reductase - warfarin inhibits
20 to 40
Porphobilinogen - delta ALA - uroporphyrin
10. What are the azuraphilic granules in PMNs
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Lysosomes
Helminth infections major basic protein
11. bcl -2 t(14;18) adults
Follicular lymphoma - indolent course
Orotic aciduria
Nl PT - elevated PTT - intrinsic pathway defect
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
12. poikilocytosis
Inc serum iron - normal TIBC - inc ferratin
Varying shapes
Nl PT - elevated PTT - intrinsic pathway defect
PGI2 - NO inc blood flow - dec platelet aggregation
13. Mutation in 3' untranslated region associated with venous clots
Aplastic anemia - pancytopenia
Hereditary elloptocytosis
Extrinsic - I - II - V - VII and X
Prothrombin gene mutation
14. What are the presenting symptoms of acute intermittent porphyria
Lacunar in nodular sclerosing variant
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
Beta 4
Her next Rh+ fetus
15. What is the pathogenesis of ACD?
Aplastic anemia - pancytopenia
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Howell Jolly bodies
16. What do you see in vit K def
ATIII def
Eleveated PT - PTT
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
MAHA
17. hypersegmented PMNs - glossitis - dec B12 - inc homocysteine - inc methymalonic acid
Collagen - BM - activated platelets
Down - up - down
All < 15 - AML = median onset around 60 - CML = 30 to 60 - and CLL > 60
B12 def
18. What happens in betal thal minor?
G6PD
Beta chain underproduced - asymptomatic - heterozygote
Leukemia
Fibrinogen
19. What does decreasing heme do to ALA synthase activity?
PGI2 - NO inc blood flow - dec platelet aggregation
5- FU - AZT - hydroxyurea
Inc
VIII
20. What do auer rods stain with
TRAP (tartrate resistant acid phosphatase
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
Peroxidase
21. What do the platelets bind? What is the step called
Paroxysmal nocturnal hemoglobinuria
They bind vWF via GpIb
Anemia of chronic disease - Aplastic anemia - kidney disease
Sideroblastic anemia
22. What role does antithrombin play?
Incactivates II - VII - IX - X - XI - XII
Blistering cutaneous photosens - most common porphyria
Diffuse Large b cell lymphoma
Intravascular
23. What is contained within the azurophilic granules of PMNs
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
TPA - cleavage of fibrin mesh
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
Polycythemia vera
24. Which lymphoma is characterized by localized involvement with a single group of nodes and mediastinal lymphadenopathy
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
Hodgkin
All trans retinoic acid
No platelet clumping
25. What are the variants of the RS cells
Malnutrition - malabsoprtion - impaired metabolism - inc requirement as in an hemolytic anemia or pregnancy
Nl PT - elevated PTT - intrinsic pathway defect
Leukemia
Lacunar in nodular sclerosing variant
26. Megakaryocytosis
Essential thrombocytosis
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Cromolyn sodium
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
27. anti - Ig antibody added to patients RBCs;
EBV
Helminth infections major basic protein
Langerhans cell histiocytosis
Direct coombs - agglutinate if RBCs are coated with Ig
28. Why can newborns with sickle cell be asymptomatic
Paraprotein spike - monoclonal protein
Inc HbF and dec HbS
Epoxide reductase - warfarin inhibits
Lysine for glutamate at position 6
29. What is factor V leidin?
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
30. Where are basophils found?
Blood
Diffuse Large b cell lymphoma
B6 therapy (pyrodixine)
Plasma cell
31. abnormal clone of hematopoetic stem cells are increasingly sensitive to growth factors - inc RBC - JAK2 mut
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
MHC II and Fc receptors
Uroporphyrin (tea colored urine)
Polycythemia vera
32. What is the tx for aplastic anemia
Aplastic anemia - pancytopenia
Multiple myeloma
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
Leukemia
33. What is the enzyme defect in Porphyria cutanea tarda
Indirect coombs - agglutinate if serum anti RBC surface Ig
Tissue factor converst the VII and VIIa
Lead poisoning - rRNA causes aggregration of ribosomes and basophilic stippling
Uroporphyrinogen decarboxylase
34. Where are monocytes typically found - where do they go - and What do the differentiate into?
Extravascular hemolysis
Blod - tissue - MACS
Hairy cell leukemia
Inc lymphoctes - and less RS cells
35. What is the Ddx for for a macrocytic anemia
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
Kids= exposure to lead paint - adults = battery - ammunition factory
Protein S - cleaves and invactivates Va and VIIIa
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
36. Where do B cells arise from - mature - and migrate to...
Glanzmann's throbmasthenia - GpIIb/IIIa - nl platelets - inc BT
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
Spleen
Marrow - marrow - follicles of lymph nodes - white pulp of spleen (unencapsulated lymphoid tissue)
37. What is the ddx for aplastic anemia
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
38. Can B cells function as APCs?
Yes - via MHC II
HyperCalcemia - Renal insuff - Anemia - Bone lytic lesions/Back pain
TRAP (tartrate resistant acid phosphatase
Bone marrow infiltration - myelofibrosis
39. Serum iron - transferrin - ferritin lab values for pregs - OCP use
Nl - up - nl
Ticlopidine/clopidogrel
Sideroblastic anemia
Sheets of lymphocytes interspersed with macs
40. What is the Ddx for a normocytic - normochromic anemia?
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
CLL (SLL without the peripheral lymphocytosis
Beta thal
Extravascular
41. Crew cut on skull xray due to marrow supression - 8% of AA population - single amino acid replacement in beta chain at position 6 - after a DNA point mutation
Direct coombs - agglutinate if RBCs are coated with Ig
Imatinib - anti bcr abl
Sickle cell
Low O2 in papilla; can also get microhematuria from medullary infarcts
42. What is the are the presenting symptoms of lead poisoning in kids and adults
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Megakaryocytes
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
Alpha thal - asian and african american
43. What substance prevents mast cells degranulation?
No antigen - both antibodies
Schistocytes and inc LDH
120 days
Cromolyn sodium
44. What vitamin is a cofactor for the first step of heme synthesis
Splicing sites and promotor sequences
Thrombotic thrombocytopenic purpura
Inducers of primary antibody response
B6
45. What are the likely exposures of kids and adults for lead poisoning
2 to 10
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Inducers of primary antibody response
Kids= exposure to lead paint - adults = battery - ammunition factory
46. Teardrop cell
B6
Sideroblastic anemia
40 to 75
Bone marrow infiltration - myelofibrosis
47. Plasma cell neoplasm
Schistocytes and inc LDH
Multiple myeloma
Hereditary spherocytosis
40 to 50
48. What cell is primarily involved in non Hod lymph
Positive osmootic fragility test and splenectomy
B cells
Idiopathic thrombocytopenia (ITP)
Sickle cell
49. Where are mast cells found
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
Parvovirus
Protein S - cleaves and invactivates Va and VIIIa
Tissue
50. What is the life spance of a platelet?
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
Glycine and succinyl - coa
8-10 days
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia