Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Causes of iron def?
Bleeding - malnutrition/absorption - inc demand pregs
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Lacunar in nodular sclerosing variant
Varying shapes

2. Who are the professional APCs?
Tissue factor converst the VII and VIIa
Dendritic cells?
Langerhans cells
Pos

3. Adults present with cutaneous patches/nodules - indolent CD4+
Paraprotein spike - monoclonal protein
Her next Rh+ fetus
Mycosis fundgoides/Sezary syndrome
Bernard soulier

4. Which drugs can cause macrocytic anemia?
5- FU - AZT - hydroxyurea
Nl - up - nl
Positive osmootic fragility test and splenectomy
Anti Rh

5. what proteins can be defective in HS?
5- FU - AZT - hydroxyurea
Liver disease - abetalipoproteinemia - acntho = spiny
Ringed sideronblasts with iron laden mitochondria
Ankryin - band 4.1 or spectrin

6. What is the effect of ACE on bradykinin
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
Pyruvate kinase def - extravascular
Deficiency in factor VIII
Inactivates it

7. What does plasmin do?
Degrades fibrin mesh and converts C3 to C3a
Up - down - up
Rhogam - Rh antigen immunoglobulin
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia

8. Blood type A
Petechiae
ATIII def
Porphyrias
A antigen and B antibodies

9. What does increasing heme do to ALA synthase activity
Dec
CLL (SLL without the peripheral lymphocytosis
Both alpha and beta thal
Varying sizes

10. Conditions of defective heme synthesis leading to accumulation of heme precurors
Inc lymphoctes - and less RS cells
Birbeck granules
Porphyrias
Folate def

11. Bone pain plus anemia
Multiple myeloma
Ankryin - band 4.1 or spectrin
Lead poisoning - rRNA causes aggregration of ribosomes and basophilic stippling
Down - up - down

12. inc HbF on electrophoresis
All
Both alpha and beta thal
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
Myelofibrosis (marow is crying being its fibrosed'

13. What is monoclonal expansion without symptoms associated with multiple myeloma?
Multiple myeloma
MGUS - monoclonal gammopathy of undetermined significance
Varying sizes
Tissue

14. Plasma cell neoplasm
Fibrinogen bind GpIIb/IIIa and links platelts
Multiple myeloma
Nodular sclerosing
MAHA

15. What indicated a good prognosis in Hodgkin lymphoma?
HyperCalcemia - Renal insuff - Anemia - Bone lytic lesions/Back pain
Leukemia
Hereditary spherocytosis - G6PD - sickle cell
Inc lymphoctes - and less RS cells

16. Which immunoglobulin is involved in warm agglutination?
Epoxide reductase - warfarin inhibits
Bone marrow - thymus - blood (80% of circulating lymphos are T)
B12/folate def
IgG - Warm is GREAT

17. Intrinsic pathway coagulation defect and defect in platelet plug formation - most common inherited bleeding disorder - AD
Easy gas exchange
Paroxysmal nocturnal hemoglobinuria
VWD
Gp1b

18. hemolytic in a newborn - dec ATP and rigid RBCs
Pyruvate kinase def - extravascular
Nl - up - nl
Malaria - Babesia
No

19. What is the mutation in HbC
Lysine for glutamate at position 6
Varying sizes
Yes - via MHC II
CD15 and CD30 pos

20. Deficiency in vWF

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

21. What do the iron studies show in sideroblastic anemia
Dec synthesis of factors 1972 - protein C/S
Produce antibody - lots of RER and golgi
VWF and fibrinogen
Inc serum iron - normal TIBC - inc ferratin

22. What is their role?
Signs and sx of aplastic anemia
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
Howell Jolly bodies
Inducers of primary antibody response

23. Where are 1/3 of platelets stored
Prothrombin gene mutation
Factor V resistant to activated protein C's inhibition
8-10 days
Spleen

24. What is the pathogenesis of aplastic anemia with kidney disease
Porphyrias
Decrease EPO
Hodgkin
20 to 40

25. What does the blood smear show in glanzmann's?
Ewing sarcoma
Diffuse Large b cell lymphoma
DIC
No platelet clumping

26. What does hairy cell leukemia stain with
Myelofibrosis (marow is crying being its fibrosed'
Valine for glutamate
Yes - via MHC II
TRAP (tartrate resistant acid phosphatase

27. Elderly - mature b cell tumor with filamentous - hairlike projections
Fe def - thal - pb poison - sideroblastic anemia
Ankryin - band 4.1 or spectrin
Hairy cell leukemia
Von Willebrand's disease

28. Serum iron - transferrin - ferritin lab values for lead poisoning anemia
Abciximab
Up - down - nl
Protein S - cleaves and invactivates Va and VIIIa
TRAP (tartrate resistant acid phosphatase

29. Basophilica stippling
B12 def
TRAP (tartrate resistant acid phosphatase
Mantle cell - older males
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning

30. What role does antithrombin play?
T(9;22) bcr abl
Ringed sideronblasts with iron laden mitochondria
TRAP (tartrate resistant acid phosphatase
Incactivates II - VII - IX - X - XI - XII

31. What is the Ddx for a normocytic - normochromic anemia?
Up - down - nl
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
Bite cells and Heinz bodies
Round densly staining nucleus with a small amount of pale cytoplasm

32. defect in alpha globin gene - dec alpha globin synth - disease and populations?
Inactivates it
Dec plasma volume
Alpha thal - asian and african american
Lacunar in nodular sclerosing variant

33. What do labs show in DIC?
Heinz bodies - seen in alpha thal and G6PD
Histaminase and arylsulfatase
Schistocytes - inc fibrin split products (D- dimers) - dec fibrinogen - dec factors V and VIII
Burkitt lymphoma

34. drug that inhibits ADP induced expression of GpIIb/IIIa
20 to 40
Ticlopidine/clopidogrel
Uroporphyrin (tea colored urine)
Reed - sternberg cells

35. What is the treatment for acute intermittent porphyria
Glucose and heme - which inhibit ALA synthase
Plummer - vinson syndrome
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
Off center nuclues - clock face chromatin

36. Acanthocyte (spur cell)
Produce antibody - lots of RER and golgi
Abciximab
Spleen
Liver disease - abetalipoproteinemia - acntho = spiny

37. What do you see in vit K def
20 to 40
5- FU - AZT - hydroxyurea
Eleveated PT - PTT
Porphobilinogen deaminase aka uroporphyrinogen I synthase

38. Teardrop cell
Anemia of chronic disease - Aplastic anemia - kidney disease
Bone marrow infiltration - myelofibrosis
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
VIII

39. Aplastic crisis after parvovirus - autosplenectomy - salmonella osteomyelitis - painful crisis - renal papillary necrosis - splenic sequestration
Complications of sickle cell anemia
GpIIb/IIIa
Multiple myeloma
EBV

40. When do you see MAHA?
Multiple myeloma
Histamine - heparin - and eosinohil chemotactic factors
Inactivates it
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis

41. Bite cell
G6PD
20 to 40
Malnutrition - malabsoprtion - impaired metabolism - inc requirement as in an hemolytic anemia or pregnancy
Lysosomes

42. Is HS extravascular or intravascular?
Extravascular
Lysine for glutamate at position 6
Ringed sideronblasts with iron laden mitochondria
Both alpha and beta thal

43. Which lymphoma is characterized by localized involvement with a single group of nodes and mediastinal lymphadenopathy
They bind vWF via GpIb
Hodgkin
Inappropriate absolute with inc RBCs and EPO
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium

44. Where are basophils found?
SLE - CLL - alpha methyldopa
Blood
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
Inc

45. What substances are released in mast cell degranulation
Protein S - cleaves and invactivates Va and VIIIa
Histamine - heparin - and eosinohil chemotactic factors
Langerhans cell histiocytosis
ATIII def

46. Serum iron - transferrin - ferritin lab values for pregs - OCP use
Malaria - Babesia
Nl PT - elevated PTT - intrinsic pathway defect
Nl - up - nl
Lymphoma

47. What CD molecules are on RS cells
CD15 and CD30 pos
Howell Jolly bodies
No platelet clumping
Round densly staining nucleus with a small amount of pale cytoplasm

48. Basophilic nuclear remnants fonud in RBCs
Howell - Jolly bodies - hypo/asplenia
Alpha thal - asian and african american
Aspirin
Lysosomes

49. What does CRAB stand for in multiple myeloma
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
HyperCalcemia - Renal insuff - Anemia - Bone lytic lesions/Back pain
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
Polycythemia vera

50. Crew cut on skull xray due to marrow supression - 8% of AA population - single amino acid replacement in beta chain at position 6 - after a DNA point mutation
Sickle cell
Mycosis fundgoides/Sezary syndrome
Birbeck granules
Porphobilinogen - delta ALA - uroporphyrin