Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What are some causes of cold agglutinin anemia
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Cold - seen in CLL - mycoplasma pneumoniae infections or infectious mononucleosis
Anti Rh
Dec plasma volume

2. What does antithrombin do and What activates it?
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
All trans retinoic acid
Prothrombin gene mutation

3. What percentage of WBCs are eosinophils?
Schistocytes and inc LDH
Peroxidase
Schistocytes - inc fibrin split products (D- dimers) - dec fibrinogen - dec factors V and VIII
1 to 6

4. From what cells are platelets derived from
Schistocytes - inc fibrin split products (D- dimers) - dec fibrinogen - dec factors V and VIII
Blistering cutaneous photosens - most common porphyria
DIC
Megakaryocytes

5. Deficiency in vWF

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

6. What does decreasing heme do to ALA synthase activity?
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
Inc
Howell Jolly bodies
Spleen

7. Which infections can cause MAHA?
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Complications of sickle cell anemia
Malaria - Babesia
Down - up - down

8. What is the difference of presentation of Burkitt in Africa vs the United States
Fc
Orotic aciduria
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead
Africa = Jaw lesion - US = pelvis or abdomen

9. What do you see in vit K def
Eleveated PT - PTT
Intravascular hemolysis
Glanzmann's throbmasthenia - GpIIb/IIIa - nl platelets - inc BT
Bone marrow - thymus - blood (80% of circulating lymphos are T)

10. Which immunoglobulin is involved in warm agglutination?
All
Histamine - heparin - and eosinohil chemotactic factors
DIC
IgG - Warm is GREAT

11. Where are mast cells found
Tissue
Mycosis fundgoides/Sezary syndrome
Hereditary spherocytosis - G6PD - sickle cell
Protein S - cleaves and invactivates Va and VIIIa

12. What is the general pathology of a macrocytic anemia?
DNA synth impaired - maturation of nucleus delayed relative to maturation of cytoplasm
Decrease EPO
VWF and fibrinogen
B cells

13. inhibition of ferrochelatase and ALA dehydrogenase leading to dec heme synthesis - also inhibition of rRNA degradation
Varying sizes
Inc lymphoctes - and less RS cells
CLL (SLL without the peripheral lymphocytosis
Lead poisoning - rRNA causes aggregration of ribosomes and basophilic stippling

14. What percentage of WBCs are basophils - and What is found in their basophilic granules?
CML to AML or All
Protoporphyrin
Plasma cell
< 1% - heparin - histamine - LTD-4 - other vasoactive amines

15. What reveresible things can a sideroblastic anemia
Epoxide reductase - warfarin inhibits
Lacunar in nodular sclerosing variant
Lead - and EtOH
Bite cells and Heinz bodies

16. What state is commonly associated with nonHod lymphoma
HIV or immunosupression
Ringed sideronblasts with iron laden mitochondria
TXA2 - dec blood flow - inc platelet aggregation
Inc UCB

17. What is the accumulated substance in lead poisoning
ADP and Ca
Protoporphyrin (blood)
Orotic aciduria
G6PD

18. Serum iron - transferrin - ferritin lab values for pregs - OCP use
Rhogam - Rh antigen immunoglobulin
Dec
Nl - up - nl
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis

19. What virus is associated with Burkitt lymphoma
Myelofibrosis (marow is crying being its fibrosed'
EBV
Exposed collagen upon endothelial damage
Nodular sclerosing

20. What does the blood smear show in glanzmann's?
Lead - and EtOH
No platelet clumping
Round densly staining nucleus with a small amount of pale cytoplasm
Macrohemorrhage - hemarthroses - easy bruising

21. What is monoclonal expansion without symptoms associated with multiple myeloma?
B12 def
MGUS - monoclonal gammopathy of undetermined significance
T(9;22) bcr abl
AML

22. What is the tx for vWD
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Birbeck granules
Down - down - up
Gp1b

23. What do labs show in DIC?
Sideroblastic anemia
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Myelofibrosis (marow is crying being its fibrosed'
Schistocytes - inc fibrin split products (D- dimers) - dec fibrinogen - dec factors V and VIII

24. Serum iron - transferrin - ferritin lab values for anemia of chronic disease
They bind vWF via GpIb
120 days
Malnutrition - malabsoprtion - impaired metabolism - inc requirement as in an hemolytic anemia or pregnancy
Down - down - up

25. inc WBC count with left shift - inc leukocyte alkaline phosphatase - often due to infection
Leukemoid reaction
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
CML to AML or All

26. tennis rackets on EM
Marrow - marrow - follicles of lymph nodes - white pulp of spleen (unencapsulated lymphoid tissue)
VWF carries/protects factor VIII
Birbeck granules
TPA - cleavage of fibrin mesh

27. What is the treatment for acute intermittent porphyria
Glucose and heme - which inhibit ALA synthase
GpIIb/IIIa
Complications of sickle cell anemia
Folate def

28. What is the ddx for aplastic anemia

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

29. What indicated a good prognosis in Hodgkin lymphoma?
CLL (SLL without the peripheral lymphocytosis
Inc lymphoctes - and less RS cells
T(12;21)
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin

30. What distinguishes multiple myeloma fromk Waldenstroms macroglobulinemia?
Ringed sideronblasts with iron laden mitochondria
No lytic bone lesions in WM
DIC
DDAVP (desmopressin) which releases stored vWF stored in endothelium

31. What is the life spance of a platelet?
Diffuse Large b cell lymphoma
Common a few days after oxidative stress in a pt with G6PD
Nl PT - elevated PTT - intrinsic pathway defect
8-10 days

32. Where are 1/3 of platelets stored
Inappropriate absolute with inc RBCs and EPO
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
Spleen
Hereditary elloptocytosis

33. RBCs damagaed from passing through obstructed - narrowed vessel lumina
Intrinsic - all factors except - VII - XIII
EBV
MAHA
Inc serum iron - normal TIBC - inc ferratin

34. anti - Ig antibody added to patients RBCs;
EBV
Mycosis fundgoides/Sezary syndrome
Plummer - vinson syndrome
Direct coombs - agglutinate if RBCs are coated with Ig

35. Elderly - mature b cell tumor with filamentous - hairlike projections
Blasts > 5%
Hairy cell leukemia
CML
Orotic aciduria

36. What is the pattern of involvement and spread for nonHod lympho
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
Sideroblastic anemia
Macrohemorrhage - hemarthroses - easy bruising
DIC - TTP/HUS - traumatic hemolysis

37. What symptoms are associated with Hodgkin lymphoma
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
B symptoms - fever night sweats - weight loss
Glycine and succinyl - coa
Complications of sickle cell anemia

38. t(11:22)
Ewing sarcoma
Inc vasodiltion - inc perm - inc pain
Extravascular
Sickle cell

39. What do platelets interact with to form a hemostatic plug
Hereditary spherocytosis - autoimmune hemolysis
Fibrinogen
Lysosomes
Porphyrias

40. What the alpha granules contain in platelets?
Multiple myeloma
Lymphoma
MGUS - monoclonal gammopathy of undetermined significance
VWF and fibrinogen

41. Where are basophils found?
Blood
Anti Rh
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT
Myelofibrosis (marow is crying being its fibrosed'

42. How do platelet disorders present?
Induces differentiation of myeloblasts
Complications of sickle cell anemia
Sickle cell
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia

43. What substance is Fe added to to yield heme
Protoporphyrin
B symptoms - fever night sweats - weight loss
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Mantle cell lymphoma

44. lymphoid neoplasms with widespread involvement of bone marrow - tumor cells usually foind in peripheral blood
Inc HbF and dec HbS
Inc HbA2 on electrophoresis
Leukemia
Polycythemia vera

45. What is the affected enzyme in acute intermittment porphyria
TPA - cleavage of fibrin mesh
Porphobilinogen - delta ALA - uroporphyrin
Essential thrombocytosis
G6PD

46. What is the are the presenting symptoms of lead poisoning in kids and adults
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
...
Mantle cell - older males
PGI2 - NO inc blood flow - dec platelet aggregation

47. Blood type A
ADP and Ca
A antigen and B antibodies
Bone marrow infiltration - myelofibrosis
Produce antibody - lots of RER and golgi

48. What are the anti aggregation factors?
PGI2 - NO inc blood flow - dec platelet aggregation
Deficiency in factor VIII
EBV
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread

49. What is hemophiliia A
VWF and fibrinogen
Deficiency in factor VIII
Plummer - vinson syndrome
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT

50. Which substrates begin the heme synthesis pathway
Tissue factor converst the VII and VIIa
Porphyrias
Inc HbA2 on electrophoresis
Glycine and succinyl - coa