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Test your basic knowledge |
Hemeonc
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the therapy for CML (philly chrom)
CNS and testis
All < 15 - AML = median onset around 60 - CML = 30 to 60 - and CLL > 60
Valine for glutamate
Imatinib - anti bcr abl
2. What is appropriate absolute polycythemia
2 to 10
Glucose and heme - which inhibit ALA synthase
Inc RBC - dec O2 sat - inc EPO
Bernard soulier
3. What is the pathogenesis of TTP?
PGI2 - NO inc blood flow - dec platelet aggregation
Inc large vWF multimers - inc platelet aggregation and thrombosis
Inactivates it
Dec synthesis of factors 1972 - protein C/S
4. What are the age ranges for the various leukemias
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
All < 15 - AML = median onset around 60 - CML = 30 to 60 - and CLL > 60
Sideroblastic anemia
5. Elderly - mature b cell tumor with filamentous - hairlike projections
Hereditary elloptocytosis
Lacunar in nodular sclerosing variant
Hairy cell leukemia
Reed - sternberg cells
6. What are the four levels of alpha thal?
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
Idiopathic thrombocytopenia (ITP)
Lead poisoning - rRNA causes aggregration of ribosomes and basophilic stippling
Mantle cell - older males
7. What are dendritic cells called in the skin?
Protoporphyrin (blood)
Langerhans cells
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
Bleeding - malnutrition/absorption - inc demand pregs
8. adults - auer rods - inc circulating myeblasts on peripheral smear
AML
Incactivates II - VII - IX - X - XI - XII
Malaria - Babesia
EBV
9. Conditions of defective heme synthesis leading to accumulation of heme precurors
Porphyrias
Birbeck granules
Ewing sarcoma
Degrades fibrin mesh and converts C3 to C3a
10. What is makes a leukemia acute
Direct coombs - agglutinate if RBCs are coated with Ig
Blasts > 5%
ADP and Ca
Fibrinogen
11. Where does All spread
Inc large vWF multimers - inc platelet aggregation and thrombosis
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
CNS and testis
M3 AML (acute promyelocytic leukemia)
12. When is the peak incidence for nonHod lymphoma
Gp1b
Common a few days after oxidative stress in a pt with G6PD
Blistering cutaneous photosens - most common porphyria
20 to 40
13. What is the are the presenting symptoms of lead poisoning in kids and adults
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
Follicular lymphoma - indolent course
Tissue
Glanzmann's throbmasthenia - GpIIb/IIIa - nl platelets - inc BT
14. inc HbF on electrophoresis
Both alpha and beta thal
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Down - down - up
Direct coombs - agglutinate if RBCs are coated with Ig
15. What do you see in peripheral smear in a pt with G6PD?
Bite cells and Heinz bodies
PGI2 - NO inc blood flow - dec platelet aggregation
Hb Barts - gamma4 in defect in all 4 alpha genes
40 to 50
16. What is relative polycythemia
Dec plasma volume
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
Idiopathic thrombocytopenia (ITP)
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
17. What is the affected enzyme in lead poisoning
Factor V resistant to activated protein C's inhibition
TXA2 - dec blood flow - inc platelet aggregation
Reed - sternberg cells
Ferrocheletase and ALA dehydrogenase
18. What substance is Fe added to to yield heme
Inappropriate absolute with inc RBCs and EPO
Protoporphyrin
Follicular lymphoma - indolent course
All trans retinoic acid
19. Blood type B
Dendritic cells?
B antigena and A antibodes
Hereditary elloptocytosis
Aspirin
20. What is the age group most commonly affected by multiple myeloma
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
Africa = Jaw lesion - US = pelvis or abdomen
Petechiae
40 to 50
21. Which pathway and factors are tested in the PTT test
Intrinsic - all factors except - VII - XIII
CNS and testis
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
Down - down - up
22. Basophilic nuclear remnants fonud in RBCs
Howell - Jolly bodies - hypo/asplenia
90% anearobically from glucose to lactate - 10% from HMP shunt
Megakaryocytes
Produce antibody - lots of RER and golgi
23. What is the age breakdown for hodgkins
Polycythemia vera
Bimodal - men>women - except for nodular sclerosing type
Dec
SLE - CLL - alpha methyldopa
24. What causes renal papillary necrosis in sickle cell
Low O2 in papilla; can also get microhematuria from medullary infarcts
Langerhans cells
A antigen and B antibodies
Inc lymphoctes - and less RS cells
25. hypersegmented PMNs - glossitis - dec folate - inc homocysteine - nl methylmalonic acid
Tissue
Incactivates II - VII - IX - X - XI - XII
Lysine for glutamate at position 6
Folate def
26. fatigue - malaise - pallor - purpura - mucosal bleeding - petechiae - infection
Sickle cell anemia
Inc UCB
Signs and sx of aplastic anemia
Folate def
27. Which enzyme converts vit k to activated vit k - and what substance inhibits this enzyme
Up - down - up
Epoxide reductase - warfarin inhibits
Blod - tissue - MACS
B6 therapy (pyrodixine)
28. What do auer rods stain with
Mantle cell lymphoma
Peroxidase
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
Thrombotic thrombocytopenic purpura
29. Target cell
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30. Upregulated growth of leukocytes in bone marro
T(12;21)
Hereditary spherocytosis - G6PD - sickle cell
Produce antibody - lots of RER and golgi
Leukemia
31. What is the pathogenesis of ACD?
Malaria - Babesia
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
T(9;22) bcr abl
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
32. What happens in beta thal major?
VWD
Protoporphyrin (blood)
Beta chain underproduced - asymptomatic - heterozygote
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis
33. What is the receptor for vWF
Gp1b
Liver disease - abetalipoproteinemia - acntho = spiny
DIC
Heinz bodies - seen in alpha thal and G6PD
34. Eosinophils are highly phagocytic For what kind of complex?
Antigen - antibody
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Down - down - up
Glycine and succinyl - coa
35. Which infections can cause MAHA?
Malaria - Babesia
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
Varying sizes
Hb Barts - gamma4 in defect in all 4 alpha genes
36. normal RBCs added to patient's serum
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
Hereditary spherocytosis
Bleeding - malnutrition/absorption - inc demand pregs
Indirect coombs - agglutinate if serum anti RBC surface Ig
37. X linked defect in delta aminolevulinic acid synthase gene causes a defect in hemesynthesis
Protein S - cleaves and invactivates Va and VIIIa
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
Inappropriate absolute with inc RBCs and EPO
Sideroblastic anemia
38. What activates the intrinsic pathway?
Blasts > 5%
IFN gama
Inc vasodiltion - inc perm - inc pain
Collagen - BM - activated platelets
39. What are the extrinsic hemolytic normocytic anemias?
Langerhans cell histiocytosis
Lymphoma
...
B6 therapy (pyrodixine)
40. Causes of iron def?
Bleeding - malnutrition/absorption - inc demand pregs
VWD
M3 AML (acute promyelocytic leukemia)
Idiopathic thrombocytopenia (ITP)
41. Basophilica stippling
Off center nuclues - clock face chromatin
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Mantle cell lymphoma
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
42. What converts plasminogen to plasm and What does plasmin do?
TPA - cleavage of fibrin mesh
Polycythemia vera
Factor V resistant to activated protein C's inhibition
Hb Barts - gamma4 in defect in all 4 alpha genes
43. What the alpha granules contain in platelets?
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
VWF and fibrinogen
CLL (SLL without the peripheral lymphocytosis
Beta thal
44. What are the variants of the RS cells
DIC - TTP/HUS - traumatic hemolysis
Off center nuclues - clock face chromatin
Lacunar in nodular sclerosing variant
Cold - seen in CLL - mycoplasma pneumoniae infections or infectious mononucleosis
45. What is the pattern of involvement and spread for nonHod lympho
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
Ankryin - band 4.1 or spectrin
Sideroblastic anemia
46. Is G6PD intravascular or extravascular
Intravascular
DDAVP (desmopressin) which releases stored vWF stored in endothelium
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
Factor V resistant to activated protein C's inhibition
47. What do you see on peripheral smear with sideroblastic anemia
Folate def
Liver disease - abetalipoproteinemia - acntho = spiny
Ringed sideronblasts with iron laden mitochondria
Von Willebrand's disease
48. What is the ddx for aplastic anemia
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49. deficiency in ADAMTS13 leading to dec degradation of vWF
Thrombotic thrombocytopenic purpura
TRAP (tartrate resistant acid phosphatase
Factor V resistant to activated protein C's inhibition
Produce antibody - lots of RER and golgi
50. What does ectopic EPO produce
Alpha thal - asian and african american
Abciximab
Varying sizes
Inappropriate absolute with inc RBCs and EPO