Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Deficiency in GpIIb/IIIa

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

2. hypocellular bone marrown tih fatty infiltration
Common a few days after oxidative stress in a pt with G6PD
Uroporphyrin (tea colored urine)
Aplastic anemia - pancytopenia
Examples of oxidative stress

3. abnormal clone of hematopoetic stem cells are increasingly sensitive to growth factors - inc RBC - JAK2 mut
Polycythemia vera
Valine for glutamate
No antigen - both antibodies
G6PD

4. What causes the physiologic chloride shift and What does the chloride shift do?
Liver disease - abetalipoproteinemia - acntho = spiny
Dec synthesis of factors 1972 - protein C/S
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
Adult T cell lymphoma - presents with cutaneous lesions

5. What is the enzyme defect in Porphyria cutanea tarda
Von Willebrand's disease
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Malaria - Babesia
Uroporphyrinogen decarboxylase

6. What begins the extrinsic pathway?
Bone marrow infiltration - myelofibrosis
B antigena and A antibodes
They bind vWF via GpIb
Tissue factor converst the VII and VIIa

7. Basophilica stippling
Decrease EPO
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin

8. Drug that inhibits COX and therefore TXA2 synthesis
Aspirin
Round densly staining nucleus with a small amount of pale cytoplasm
Cold - seen in CLL - mycoplasma pneumoniae infections or infectious mononucleosis
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning

9. what proteins can be defective in HS?
B6
...
DIC - TTP/HUS - traumatic hemolysis
Ankryin - band 4.1 or spectrin

10. What do platelets release necessary for coagulation cascaed?
TPA - cleavage of fibrin mesh
40 to 50
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
ADP and Ca

11. Where are mast cells found
Fibrinogen bind GpIIb/IIIa and links platelts
Kids= exposure to lead paint - adults = battery - ammunition factory
Tissue
Ferrocheletase and ALA dehydrogenase

12. What finding you do you see in patients after splenectomy
Down - down - up
Beta 4
Extravascular
Howell Jolly bodies

13. Blood type B
B antigena and A antibodes
Off center nuclues - clock face chromatin
TXA2 - dec blood flow - inc platelet aggregation
8-10 days

14. Which enzyme converts vit k to activated vit k - and what substance inhibits this enzyme
Inactivates it
No antigen - both antibodies
Protoporphyrin (blood)
Epoxide reductase - warfarin inhibits

15. What are the etiologies of B12 def
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
Common a few days after oxidative stress in a pt with G6PD
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium

16. What is the mutation in HbS
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
Intravascular hemolysis
Valine for glutamate
8-10 days

17. What is the tx for aplastic anemia
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
AML

18. What is appropriate absolyte polycythemia associated with
CML
G6PD
Blod - tissue - MACS
Lung disease - congenital heart diseaes - and high altitude

19. What is the affected enzyme in lead poisoning
Ferrocheletase and ALA dehydrogenase
Inducers of primary antibody response
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
Collagen - BM - activated platelets

20. What does STOP Making New Thrombi stand for
Intrinsic - all factors except - VII - XIII
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
MHC II and Fc receptors
CLL (SLL without the peripheral lymphocytosis

21. What do you see a starry sky appearance in Burkitt
Sheets of lymphocytes interspersed with macs
Blod - tissue - MACS
B6
Direct coombs - agglutinate if RBCs are coated with Ig

22. drug that inhibits ADP induced expression of GpIIb/IIIa
Ferrocheletase and ALA dehydrogenase
All
Ticlopidine/clopidogrel
2 to 10

23. What distinguishes multiple myeloma fromk Waldenstroms macroglobulinemia?
Tissue factor converst the VII and VIIa
Glucose and heme - which inhibit ALA synthase
Pos
No lytic bone lesions in WM

24. What are the extrinsic hemolytic normocytic anemias?
DNA synth impaired - maturation of nucleus delayed relative to maturation of cytoplasm
Porphobilinogen deaminase aka uroporphyrinogen I synthase
...
Sheets of lymphocytes interspersed with macs

25. What is the clinical picture of hemophilia A or B
All
Macrohemorrhage - hemarthroses - easy bruising
Essential thrombocytosis
VWF and fibrinogen

26. What is hemophiliia A
B antigena and A antibodes
Her next Rh+ fetus
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
Deficiency in factor VIII

27. What is the characteristic finding for MAHA on peripheral smear?
Schistocytes - helmet cells
Follicular lymphoma - indolent course
Factor V Leiden
Idiopathic thrombocytopenia (ITP)

28. What is the treatment for lead poising?
Exposed collagen upon endothelial damage
Inc
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead
Lacunar in nodular sclerosing variant

29. Megakaryocytosis
No lytic bone lesions in WM
Positive osmootic fragility test and splenectomy
Essential thrombocytosis
Beta 4

30. t(11:22)
Porphyrias
VIII
Adult T cell lymphoma - presents with cutaneous lesions
Ewing sarcoma

31. What is the effect of ACE on bradykinin
Glanzmann's throbmasthenia
Spleen
Ferrocheletase and ALA dehydrogenase
Inactivates it

32. Causes of iron def?
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Myelofibrosis (marow is crying being its fibrosed'
1 to 6
Bleeding - malnutrition/absorption - inc demand pregs

33. What is the characteristic spread of Hodgkin Lymphoma
Macrohemorrhage - hemarthroses - easy bruising
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis
Porphobilinogen - delta ALA - uroporphyrin
Contiguous

34. What does ectopic EPO produce
Inappropriate absolute with inc RBCs and EPO
Nodular sclerosing
Bone marrow - thymus - blood (80% of circulating lymphos are T)
B12/folate def

35. From what cells are platelets derived from
Megakaryocytes
Hairy cell leukemia
VWD
Hereditary spherocytosis - G6PD - sickle cell

36. Who has more severe disease - HbSS or HbSC
Lacunar in nodular sclerosing variant
Up - down - up
Tissue
HbSS

37. What is the coombs test results in AIHA?
Hodgkin
Inactivates it
Pos
2 to 10

38. What causes hydrops fetalis
MAHA
Hb Barts - gamma4 in defect in all 4 alpha genes
T(9;22) bcr abl
Bite cells and Heinz bodies

39. Why can newborns with sickle cell be asymptomatic
Hb Barts - gamma4 in defect in all 4 alpha genes
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
Inc HbF and dec HbS
AML

40. Sickle cell
SLE - CLL - alpha methyldopa
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Sickle cell anemia
PENTAD: neurologic sx - renal sx - fever - thrombocytopenia - MAHA

41. What is contained within the azurophilic granules of PMNs
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
Lead - and EtOH
Lead poisoning - rRNA causes aggregration of ribosomes and basophilic stippling
Hereditary spherocytosis - autoimmune hemolysis

42. Serum iron - transferrin - ferritin lab values for hemochromatosis
MHC II and Fc receptors
Helminth infections major basic protein
Up - down - up
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease

43. inc HbF on electrophoresis
Eleveated PT - PTT
Lysine for glutamate at position 6
Both alpha and beta thal
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia

44. What does decreasing heme do to ALA synthase activity?
Sideroblastic anemia
Sickle cell
All trans retinoic acid
Inc

45. What CD molecules are on RS cells
CD15 and CD30 pos
Imatinib - anti bcr abl
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Idiopathic thrombocytopenia (ITP)

46. How are the nucleus and the cytoplasm characterized for lymphocytes
G6PD
Round densly staining nucleus with a small amount of pale cytoplasm
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
120 days

47. Acanthocyte (spur cell)
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
Liver disease - abetalipoproteinemia - acntho = spiny
Blistering cutaneous photosens - most common porphyria
Lymphoma

48. What do the platelets bind? What is the step called
Blistering cutaneous photosens - most common porphyria
They bind vWF via GpIb
A antigen and B antibodies
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia

49. What is the purpose of the fibrin mesh
Aspirin
Aplastic anemia - pancytopenia
Acts to stabilize platelet plug
IgG - Warm is GREAT

50. What is factor V leidin?

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183