Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What do plasma cells do
VWD
Produce antibody - lots of RER and golgi
EBV
Factor V Leiden

2. What is the are the presenting symptoms of lead poisoning in kids and adults
120 days
Hereditary spherocytosis - G6PD - sickle cell
Glanzmann's throbmasthenia - GpIIb/IIIa - nl platelets - inc BT
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination

3. Ddx for microcytic anemia
Fe def - thal - pb poison - sideroblastic anemia
HbSS
Sideroblastic anemia
Inc large vWF multimers - inc platelet aggregation and thrombosis

4. What virus can cause an aplastic crisis in pts with HS?
Parvovirus
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
VIII
Inappropriate absolute with inc RBCs and EPO

5. universal recipient
AB - no antibodies
AML
CLL (SLL without the peripheral lymphocytosis
Myelofibrosis (marow is crying being its fibrosed'

6. Which enzyme converts vit k to activated vit k - and what substance inhibits this enzyme
Epoxide reductase - warfarin inhibits
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
Signs and sx of aplastic anemia
Glycine and succinyl - coa

7. What reveresible things can a sideroblastic anemia
Varying sizes
Lead - and EtOH
Lymphoma
Lysine for glutamate at position 6

8. Tdt+ - CAllA+ - kids in the marrow - adolescent males with mediastinal mass
120 days
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis
Hydroxyurea - bone marrow transplant
All

9. What is the characteristic spread of Hodgkin Lymphoma
Blasts > 5%
Contiguous
Intravascular
Porphobilinogen deaminase aka uroporphyrinogen I synthase

10. What activates the fibrinolytic pathway?
PGI2 - NO inc blood flow - dec platelet aggregation
Megakaryocytes
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin

11. What does increasing heme do to ALA synthase activity
Inc lymphoctes - and less RS cells
Decrease EPO
Dec
Intravascular

12. Where are basophils found?
Polycythemia vera
Blood
B antigena and A antibodes
B cells

13. What is the effect of ACE on bradykinin
Acts to stabilize platelet plug
Inactivates it
Dec
Tissue factor converst the VII and VIIa

14. Where to T cells arise and mature - and migrate to...
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
SLE - CLL - alpha methyldopa
B12 in fatty acid pathways leads to subacute combined degeneration

15. Who are the professional APCs?
CML to AML or All
Glanzmann's throbmasthenia
Dendritic cells?
Dec

16. What is the therapy for the M3 variant?
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
All trans retinoic acid
Protein S - cleaves and invactivates Va and VIIIa
Bone marrow - thymus - blood (80% of circulating lymphos are T)

17. What is HbH
Beta 4
Complications of sickle cell anemia
Howell Jolly bodies
Positive osmootic fragility test and splenectomy

18. What is the characteristic lab finding on electrophoresis
Factor V resistant to activated protein C's inhibition
Inactivates it
B12/folate def
Paraprotein spike - monoclonal protein

19. What is the Ddx for for a macrocytic anemia
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
Helminth infections major basic protein
All trans retinoic acid
Mantle cell - older males

20. What activates the intrinsic pathway?
Beta thal
TXA2 - dec blood flow - inc platelet aggregation
Collagen - BM - activated platelets
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia

21. Where do you see hypersegmented polys?
Dendritic cells?
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
B12/folate def
Sheets of lymphocytes interspersed with macs

22. How are plasma cells characterized?
Tissue
PENTAD: neurologic sx - renal sx - fever - thrombocytopenia - MAHA
Helps platelts adhere to endothelium
Off center nuclues - clock face chromatin

23. What is hemophiliia A
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Schistocytes - inc fibrin split products (D- dimers) - dec fibrinogen - dec factors V and VIII
Lacunar in nodular sclerosing variant
Deficiency in factor VIII

24. What do you see on peripheral smear with sideroblastic anemia
Ringed sideronblasts with iron laden mitochondria
Contiguous
20 to 40
Down - up - down

25. What are the neuro sx of B12 def?
Easy gas exchange
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
120 days
Low O2 in papilla; can also get microhematuria from medullary infarcts

26. dec haptoglobin - inc LDH - hemoglobin in urine (paroxysmal nocturnal hemoglobinuria - mechanical destruction as in aortic stenosis or a prosthetic valve
All
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
Intravascular hemolysis
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia

27. Marrow expansion - 'crew cut' on skull x ray - skeletal deformaties - and chipmunk faces
Beta thal
Leukemia
Hodgkin
Imatinib - anti bcr abl

28. Drug that inhbits the GpIIb/IIIa directly
Abciximab
Rhogam - Rh antigen immunoglobulin
Idiopathic thrombocytopenia (ITP)
Schistocytes and inc LDH

29. Target cell

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

30. What CD molecules are on RS cells
CD15 and CD30 pos
DDAVP (desmopressin) which releases stored vWF stored in endothelium
All
Thrombotic thrombocytopenic purpura

31. What chromosomal translocation is associated with a better prognosis in All
T(12;21)
Pos
Low in CML
Lacunar in nodular sclerosing variant

32. What happens in betal thal minor?
Extrinsic - I - II - V - VII and X
Beta chain underproduced - asymptomatic - heterozygote
Fibrinogen bind GpIIb/IIIa and links platelts
Protoporphyrin (blood)

33. What virus is associated with Burkitt lymphoma
Sideroblastic anemia
EBV
Beta thal
Sickle cell

34. What is monoclonal expansion without symptoms associated with multiple myeloma?
Round densly staining nucleus with a small amount of pale cytoplasm
MGUS - monoclonal gammopathy of undetermined significance
DNA synth impaired - maturation of nucleus delayed relative to maturation of cytoplasm
G6PD

35. Serum iron - transferrin - ferritin lab values for anemia of chronic disease
Down - down - up
Extravascular
Porphobilinogen - delta ALA - uroporphyrin
G6PD

36. What is the pathogenesis of TTP?
Inc large vWF multimers - inc platelet aggregation and thrombosis
Uroporphyrinogen decarboxylase
GpIIb/IIIa
Cromolyn sodium

37. What is the characteristic histologic finding in Hodgkin Lymphoma
Reed - sternberg cells
Hydroxyurea - bone marrow transplant
Blood
5- FU - AZT - hydroxyurea

38. Deficiency in vWF

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

39. Serum iron - transferrin - ferritin lab values for lead poisoning anemia
Cold - seen in CLL - mycoplasma pneumoniae infections or infectious mononucleosis
Examples of oxidative stress
Up - down - nl
Tissue

40. Bite cell
G6PD
Polycythemia vera
Birbeck granules
PGI2 - NO inc blood flow - dec platelet aggregation

41. What substance accumulates in porphyria cutanea
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Reed - sternberg cells
Uroporphyrin (tea colored urine)
Inc HbF and dec HbS

42. What is the treatment for lead poising?
CD15 and CD30 pos
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead
Inappropriate absolute with inc RBCs and EPO
G6PD

43. What are the labs and tx for HS?
Aplastic anemia - pancytopenia
Cromolyn sodium
Sickle cell anemia
Positive osmootic fragility test and splenectomy

44. Blood type B
Intravascular
Glucose and heme - which inhibit ALA synthase
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
B antigena and A antibodes

45. What is the characteristic finding for MAHA on peripheral smear?
Multiple myeloma
Schistocytes - helmet cells
Spleen
VWF carries/protects factor VIII

46. Wilm's tumor - RCC - HCC - hydronephrosis
No lytic bone lesions in WM
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Fibrinogen bind GpIIb/IIIa and links platelts
Inappropriate absolute with inc RBCs and EPO

47. Basophilica stippling
Parvovirus
Bimodal - men>women - except for nodular sclerosing type
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Prothrombin gene mutation

48. Elderly - mature b cell tumor with filamentous - hairlike projections
IgG - Warm is GREAT
Hairy cell leukemia
1 to 6
Inc RBC - dec O2 sat - inc EPO

49. What do auer rods stain with
Peroxidase
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
Abciximab
Cromolyn sodium

50. What does 'Neutrophils Like Making Everything Better' stand for?
Down - down - up
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
Contiguous