Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. hypersegmented PMNs - glossitis - dec folate - inc homocysteine - nl methylmalonic acid
Alpha thal - asian and african american
Ankryin - band 4.1 or spectrin
B6 therapy (pyrodixine)
Folate def

2. What are the presenting symptoms of acute intermittent porphyria
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
Imatinib - anti bcr abl
SLE - CLL - alpha methyldopa
Thrombotic thrombocytopenic purpura

3. Deficiency in vWF

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

4. What does plasmin do?
No lytic bone lesions in WM
Anti Rh
Degrades fibrin mesh and converts C3 to C3a
Fibrinogen bind GpIIb/IIIa and links platelts

5. What are the four levels of alpha thal?
Plummer - vinson syndrome
Lead - and EtOH
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
Bite cells and Heinz bodies

6. inc WBC count with left shift - inc leukocyte alkaline phosphatase - often due to infection
Indirect coombs - agglutinate if serum anti RBC surface Ig
No
Bernard soulier
Leukemoid reaction

7. What finding you do you see in patients after splenectomy
EBV
Hairy cell leukemia
Howell Jolly bodies
...

8. What does ADP do?
Helps platelts adhere to endothelium
Inducers of primary antibody response
Howell Jolly bodies
Easy gas exchange

9. What activates the fibrinolytic pathway?
Histaminase and arylsulfatase
Off center nuclues - clock face chromatin
Intravascular
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin

10. What are the etiologies of B12 def
Ticlopidine/clopidogrel
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
They bind vWF via GpIb
Blasts > 5%

11. Blood type A
DIC - TTP/HUS - traumatic hemolysis
Blod - tissue - MACS
Rhogam - Rh antigen immunoglobulin
A antigen and B antibodies

12. Marrow expansion - 'crew cut' on skull x ray - skeletal deformaties - and chipmunk faces
Beta thal
Indirect coombs - agglutinate if serum anti RBC surface Ig
B12 in fatty acid pathways leads to subacute combined degeneration
20 to 40

13. What is the accumulated substance in lead poisoning
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Extravascular hemolysis
Protoporphyrin (blood)
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT

14. What causes renal papillary necrosis in sickle cell
Sideroblastic anemia
Low O2 in papilla; can also get microhematuria from medullary infarcts
EBV
Peroxidase

15. What percentage of WBCs are monocytes?
Gp1b
Up - down - nl
B12/folate def
2 to 10

16. What portion of IgE can mast cells bind
EBV
Anemia of chronic disease - Aplastic anemia - kidney disease
Rhogam - Rh antigen immunoglobulin
Fc

17. What activates the intrinsic pathway?
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Collagen - BM - activated platelets
Varying shapes
Fc

18. What is the receptor for fibrinogen?
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Her next Rh+ fetus
GpIIb/IIIa

19. Bite cell
Howell Jolly bodies
Valine for glutamate
G6PD
...

20. Mutation in 3' untranslated region associated with venous clots
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Pyruvate kinase def - extravascular
Prothrombin gene mutation
Anti Rh

21. What begins the extrinsic pathway?
Malaria - Babesia
Tissue factor converst the VII and VIIa
Burkitt lymphoma
Bite cells and Heinz bodies

22. can be asymptomatic - often in older adults - peripheral blood lymphcytosis with smudge cells and warm antibody autoimmune hemolytic anemia
Exposed collagen upon endothelial damage
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
ATIII def
CLL (SLL without the peripheral lymphocytosis

23. Blood type B
All trans retinoic acid
B antigena and A antibodes
20 to 40
Inhibits thrombin - ixa - xa - xiia - and activated by heparin

24. anisocytosis
No platelet clumping
Burkitt lymphoma
Varying sizes
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning

25. What does ectopic EPO produce
Liver disease - abetalipoproteinemia - acntho = spiny
Inappropriate absolute with inc RBCs and EPO
Lead poisoning - rRNA causes aggregration of ribosomes and basophilic stippling
Glanzmann's throbmasthenia - GpIIb/IIIa - nl platelets - inc BT

26. What does antithrombin do and What activates it?
Inc HbA2 on electrophoresis
Signs and sx of aplastic anemia
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Yes - via MHC II

27. What is their role?
Inc HbA2 on electrophoresis
Inducers of primary antibody response
Lysine for glutamate at position 6
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin

28. Defect in platelet to platelet adhesion - receptor - disorder - platelet count and bleeding time

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

29. What is the affected enzyme in lead poisoning
Sickle cell anemia
Inc serum iron - normal TIBC - inc ferratin
Hairy cell leukemia
Ferrocheletase and ALA dehydrogenase

30. Which pathway and factors are tested in the PTT test
CD15 and CD30 pos
Sheets of lymphocytes interspersed with macs
Intrinsic - all factors except - VII - XIII
Aplastic anemia - pancytopenia

31. What do platelets release necessary for coagulation cascaed?
Petechiae
B12 in fatty acid pathways leads to subacute combined degeneration
ADP and Ca
Beta 4

32. What are the labs and tx for HS?
Marrow - marrow - follicles of lymph nodes - white pulp of spleen (unencapsulated lymphoid tissue)
Varying shapes
Dendritic cells?
Positive osmootic fragility test and splenectomy

33. In a Rh - mother who has developed anti Rh antibodies - who is at risk of hemolytic disease?
G6PD
Langerhans cell histiocytosis
HIV or immunosupression
Her next Rh+ fetus

34. What do the dense granules contain in platelets
Varying sizes
Deficiency in factor VIII
ADP and Ca
Birbeck granules

35. Serum iron - transferrin - ferritin lab values for lead poisoning anemia
EBV
TRAP (tartrate resistant acid phosphatase
Up - down - nl
VWF carries/protects factor VIII

36. What is contained within the azurophilic granules of PMNs
Low O2 in papilla; can also get microhematuria from medullary infarcts
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
CNS and testis
PENTAD: neurologic sx - renal sx - fever - thrombocytopenia - MAHA

37. What do platelets interact with to form a hemostatic plug
Ringed sideronblasts with iron laden mitochondria
Hereditary elloptocytosis
Uroporphyrinogen decarboxylase
Fibrinogen

38. What is the clinical picture of hemophilia A or B
Macrohemorrhage - hemarthroses - easy bruising
Leukemia
Histamine - heparin - and eosinohil chemotactic factors
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread

39. What is the characteristic histologic finding in Hodgkin Lymphoma
All
G6PD
Mantle cell lymphoma
Reed - sternberg cells

40. What is the characteristic finding for MAHA on peripheral smear?
Howell - Jolly bodies - hypo/asplenia
Schistocytes - helmet cells
Sideroblastic anemia
M3 AML (acute promyelocytic leukemia)

41. What percentage if WBCs are polys?
GpIIb/IIIa
40 to 75
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
Decrease EPO

42. Elliptocyte
Collagen - BM - activated platelets
Hereditary elloptocytosis
No platelet clumping
Histamine - heparin - and eosinohil chemotactic factors

43. tennis rackets on EM
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
Birbeck granules
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
No

44. Deficiency in GpIIb/IIIa

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

45. What do you see in vit K def
Eleveated PT - PTT
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
Histamine - heparin - and eosinohil chemotactic factors

46. What does the large SA:volume ratio in RBCs help facilitate?
Easy gas exchange
Megakaryocytes
40 to 75
Down - up - down

47. Wilm's tumor - RCC - HCC - hydronephrosis
Langerhans cell histiocytosis
B12 def
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO

48. Ddx for microcytic anemia
120 days
Examples of oxidative stress
Fe def - thal - pb poison - sideroblastic anemia
Hereditary spherocytosis - G6PD - sickle cell

49. What is the tx for aplastic anemia
G6PD
Folate def
Intravascular hemolysis
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF

50. What are the main associations with multiple myeloma?
Nodular sclerosing
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
Lysosomes
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)