SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
Hemeonc
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. How does the therapy for M3 vairant work?
Essential thrombocytosis
AB - no antibodies
Induces differentiation of myeloblasts
Porphobilinogen deaminase aka uroporphyrinogen I synthase
2. Which infections can cause MAHA?
Inducers of primary antibody response
Sideroblastic anemia
Kids= exposure to lead paint - adults = battery - ammunition factory
Malaria - Babesia
3. What are the pro aggregation factors?
Blistering cutaneous photosens - most common porphyria
TXA2 - dec blood flow - inc platelet aggregation
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
B6 therapy (pyrodixine)
4. What is the age breakdown for hodgkins
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
Protoporphyrin
Bimodal - men>women - except for nodular sclerosing type
Uroporphyrinogen decarboxylase
5. Which immunoglobulin is involved in warm agglutination?
Induces differentiation of myeloblasts
Glanzmann's throbmasthenia
Reed - sternberg cells
IgG - Warm is GREAT
6. hypocellular bone marrown tih fatty infiltration
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
40 to 50
Aplastic anemia - pancytopenia
7. Where are monocytes typically found - where do they go - and What do the differentiate into?
MAHA
Valine for glutamate
Blod - tissue - MACS
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead
8. Blood type A
Gp1b
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Histamine - heparin - and eosinohil chemotactic factors
A antigen and B antibodies
9. dec haptoglobin - inc LDH - hemoglobin in urine (paroxysmal nocturnal hemoglobinuria - mechanical destruction as in aortic stenosis or a prosthetic valve
Paraprotein spike - monoclonal protein
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Follicular lymphoma - indolent course
Intravascular hemolysis
10. What are some classic examples of extravascular hemolysis
Splicing sites and promotor sequences
Hereditary spherocytosis - G6PD - sickle cell
Imatinib - anti bcr abl
Bleeding - malnutrition/absorption - inc demand pregs
11. What do eosinophils defend against and What do they use to do it?
Helminth infections major basic protein
Dec synthesis of factors 1972 - protein C/S
Gp1b
Leukemoid reaction
12. Production of mutant factor V that cannot by degraded by protein C - most common cause of inherited hypercoaguability
Down - down - up
Factor V Leiden
Follicular lymphoma - indolent course
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
13. X linked - dec glutathione inc RBC susceptibility to oxidative stress
Protoporphyrin (blood)
IFN gama
Lysosomes
G6PD
14. Where does All spread
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
CNS and testis
Protoporphyrin
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
15. Defect in proteins interacting with RBC membrane skeleton and plasma membrane
Hereditary spherocytosis
CML to AML or All
Langerhans cells
Reed - sternberg cells
16. Serum iron - transferrin - ferritin lab values for pregs - OCP use
Diffuse Large b cell lymphoma
Birbeck granules
Lung disease - congenital heart diseaes - and high altitude
Nl - up - nl
17. What finding you do you see in patients after splenectomy
Complications of sickle cell anemia
All trans retinoic acid
Diffuse Large b cell lymphoma
Howell Jolly bodies
18. What is the effected enzyme in acute intermittment porphyria?
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Follicular lymphoma - indolent course
Histaminase and arylsulfatase
Bernard soulier
19. What are the azuraphilic granules in PMNs
Glanzmann's throbmasthenia
Pos
Inappropriate absolute with inc RBCs and EPO
Lysosomes
20. Elderly - mature b cell tumor with filamentous - hairlike projections
Pos
Inc lymphoctes - and less RS cells
Inducers of primary antibody response
Hairy cell leukemia
21. deficiency in ADAMTS13 leading to dec degradation of vWF
Helps platelts adhere to endothelium
Thrombotic thrombocytopenic purpura
Off center nuclues - clock face chromatin
Peroxidase
22. What are some causes of warm agglutinin autoimmune hemolytic anemia?
Both alpha and beta thal
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
B12/folate def
SLE - CLL - alpha methyldopa
23. What is the defect in beta thal?
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
Contiguous
AML
Splicing sites and promotor sequences
24. What does LEAD stand for in lead poisoning?
T(12;21)
Pyruvate kinase def - extravascular
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT
25. Where are mast cells found
B12/folate def
Degrades fibrin mesh and converts C3 to C3a
Down - down - up
Tissue
26. normal RBCs added to patient's serum
Induces differentiation of myeloblasts
Blasts > 5%
Indirect coombs - agglutinate if serum anti RBC surface Ig
TPA - cleavage of fibrin mesh
27. What is the clinical picture of hemophilia A or B
Dec plasma volume
ADP and Ca
120 days
Macrohemorrhage - hemarthroses - easy bruising
28. Widespread activation of clotting to a deficiency in clotting factors which causes a bleeding states
Ferrocheletase and ALA dehydrogenase
DIC
B12/folate def
Inappropriate absolute with inc RBCs and EPO
29. After an injury - What does vWF bind to begin platelet plug formation?
Exposed collagen upon endothelial damage
EBV
Acts to stabilize platelet plug
Kids= exposure to lead paint - adults = battery - ammunition factory
30. What the alpha granules contain in platelets?
Malnutrition - malabsoprtion - impaired metabolism - inc requirement as in an hemolytic anemia or pregnancy
VWF and fibrinogen
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
Parvovirus
31. What is the tx for sickle cell
Mantle cell - older males
Hydroxyurea - bone marrow transplant
Birbeck granules
Aspirin
32. Spherocyte
Hereditary spherocytosis - autoimmune hemolysis
Collagen - BM - activated platelets
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
33. mother's antibodies attack fetal RBCs
Multiple myeloma
Easy gas exchange
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
34. What is the coombs test results in AIHA?
Pos
40 to 75
Yes - via MHC II
Bimodal - men>women - except for nodular sclerosing type
35. Which enzyme converts vit k to activated vit k - and what substance inhibits this enzyme
Bone marrow - thymus - blood (80% of circulating lymphos are T)
ADP and Ca
Epoxide reductase - warfarin inhibits
Inc serum iron - normal TIBC - inc ferratin
36. Fibrotic obliteration of bone marow with teardrop cells
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
37. Intrinsic pathway coagulation defect and defect in platelet plug formation - most common inherited bleeding disorder - AD
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
Degrades fibrin mesh and converts C3 to C3a
Prothrombin gene mutation
VWD
38. Acanthocyte (spur cell)
Hairy cell leukemia
EBV
Liver disease - abetalipoproteinemia - acntho = spiny
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
39. Where do you see hypersegmented polys?
Macrohemorrhage - hemarthroses - easy bruising
B12/folate def
Incactivates II - VII - IX - X - XI - XII
90% anearobically from glucose to lactate - 10% from HMP shunt
40. Back pain - hemoglobinuria
Indirect coombs - agglutinate if serum anti RBC surface Ig
Common a few days after oxidative stress in a pt with G6PD
B cells
AB - no antibodies
41. Defect in platelet to platelet adhesion - receptor - disorder - platelet count and bleeding time
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
42. bcl -2 t(14;18) adults
Decrease EPO
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
Leukemia
Follicular lymphoma - indolent course
43. What is the pattern of involvement and spread for nonHod lympho
40 to 50
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
B antigena and A antibodes
Def in factor IX
44. What do labs show in ITP?
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
All trans retinoic acid
Hereditary spherocytosis - G6PD - sickle cell
45. What does Vit K deficiency cause?
Dec synthesis of factors 1972 - protein C/S
Sideroblastic anemia
B antigena and A antibodes
Complications of sickle cell anemia
46. Schisotcyte - helmet cell
Def in factor IX
DIC - TTP/HUS - traumatic hemolysis
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
T(9;22) bcr abl
47. What do platelets release necessary for coagulation cascaed?
Leukemia
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
ADP and Ca
Valine for glutamate
48. What is the characteristic spread of Hodgkin Lymphoma
Ticlopidine/clopidogrel
B6
Contiguous
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
49. What are the age ranges for the various leukemias
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Bleeding - malnutrition/absorption - inc demand pregs
All < 15 - AML = median onset around 60 - CML = 30 to 60 - and CLL > 60
Anemia of chronic disease - Aplastic anemia - kidney disease
50. Which lymphoma is characterized by localized involvement with a single group of nodes and mediastinal lymphadenopathy
Essential thrombocytosis
Blod - tissue - MACS
Hodgkin
No lytic bone lesions in WM