SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
Hemeonc
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. anti - GpIIb/IIIa antibodies leading to peripheral platelet destruction
B6 therapy (pyrodixine)
Down - up - down
Histaminase and arylsulfatase
Idiopathic thrombocytopenia (ITP)
2. What are the pro aggregation factors?
Malnutrition - malabsoprtion - impaired metabolism - inc requirement as in an hemolytic anemia or pregnancy
Factor V Leiden
Common a few days after oxidative stress in a pt with G6PD
TXA2 - dec blood flow - inc platelet aggregation
3. What is makes a leukemia acute
No platelet clumping
Blasts > 5%
Pyruvate kinase def - extravascular
Blod - tissue - MACS
4. Where are 1/3 of platelets stored
Spleen
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
ADP and Ca
Inc lymphoctes - and less RS cells
5. What is the pathogenesis of TTP?
Inc large vWF multimers - inc platelet aggregation and thrombosis
Factor V Leiden
Aspirin
MGUS - monoclonal gammopathy of undetermined significance
6. Where to T cells arise and mature - and migrate to...
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Down - down - up
Extrinsic - I - II - V - VII and X
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
7. Basophilica stippling
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Direct coombs - agglutinate if RBCs are coated with Ig
Produce antibody - lots of RER and golgi
8. What virus can cause an aplastic crisis in pts with HS?
Parvovirus
Blistering cutaneous photosens - most common porphyria
Langerhans cells
HyperCalcemia - Renal insuff - Anemia - Bone lytic lesions/Back pain
9. universal donor
No antigen - both antibodies
Beta thal
Bernard soulier
Easy gas exchange
10. What substance is Fe added to to yield heme
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
Factor V Leiden
Protoporphyrin
11. Which immunoglobulin is involved in warm agglutination?
IgG - Warm is GREAT
They bind vWF via GpIb
Hb Barts - gamma4 in defect in all 4 alpha genes
Bimodal - men>women - except for nodular sclerosing type
12. What do labs show in DIC?
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead
Schistocytes - inc fibrin split products (D- dimers) - dec fibrinogen - dec factors V and VIII
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
Inc
13. What is the life span of a normal RBC
120 days
Dec
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
Hydroxyurea - bone marrow transplant
14. What is contained within the azurophilic granules of PMNs
Essential thrombocytosis
DIC
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
HyperCalcemia - Renal insuff - Anemia - Bone lytic lesions/Back pain
15. Which cell is neoplastic in multiple myeloma
Plasma cell
Protoporphyrin
VIII
IgG - Warm is GREAT
16. What does NAACP stand for - in regards to the causes of eosinophiia?
Porphyrias
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
Myelofibrosis (marow is crying being its fibrosed'
IFN gama
17. How is beta thal minor dx
Dec synthesis of factors 1972 - protein C/S
Rhogam - Rh antigen immunoglobulin
Inc HbA2 on electrophoresis
2 to 10
18. What the alpha granules contain in platelets?
VWF and fibrinogen
MHC II and Fc receptors
Hereditary spherocytosis - autoimmune hemolysis
ATIII def
19. Which infections can cause MAHA?
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
Malaria - Babesia
All trans retinoic acid
Burkitt lymphoma
20. Aplastic crisis after parvovirus - autosplenectomy - salmonella osteomyelitis - painful crisis - renal papillary necrosis - splenic sequestration
Hairy cell leukemia
Lacunar in nodular sclerosing variant
Hydroxyurea - bone marrow transplant
Complications of sickle cell anemia
21. Elderly - mature b cell tumor with filamentous - hairlike projections
Hairy cell leukemia
Extrinsic - I - II - V - VII and X
Protoporphyrin
DIC
22. lymphoid neoplasms with widespread involvement of bone marrow - tumor cells usually foind in peripheral blood
G6PD
Leukemia
Mantle cell - older males
Inducers of primary antibody response
23. What do platelets release necessary for coagulation cascaed?
Peroxidase
ADP and Ca
Birbeck granules
B antigena and A antibodes
24. Sickle cell
DNA synth impaired - maturation of nucleus delayed relative to maturation of cytoplasm
Leukemoid reaction
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Sickle cell anemia
25. What is the effected enzyme in acute intermittment porphyria?
...
Ticlopidine/clopidogrel
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Uroporphyrinogen decarboxylase
26. Tdt+ - CAllA+ - kids in the marrow - adolescent males with mediastinal mass
Down - down - up
Tissue
Mycosis fundgoides/Sezary syndrome
All
27. What indicated a good prognosis in Hodgkin lymphoma?
Burkitt lymphoma
ADP and Ca
EBV
Inc lymphoctes - and less RS cells
28. What are the azuraphilic granules in PMNs
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
Lysosomes
AB - no antibodies
Hydroxyurea - bone marrow transplant
29. What chromosomal translocation is associated with a better prognosis in All
Contiguous
Beta 4
T(12;21)
Spleen
30. What substance prevents mast cells degranulation?
Inc UCB
Up - down - up
Mantle cell - older males
Cromolyn sodium
31. mother's antibodies attack fetal RBCs
PGI2 - NO inc blood flow - dec platelet aggregation
Dendritic cells?
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
Malaria - Babesia
32. What is the purpose of the fibrin mesh
Acts to stabilize platelet plug
Thrombotic thrombocytopenic purpura
DIC - TTP/HUS - traumatic hemolysis
Hereditary elloptocytosis
33. What finding you do you see in patients after splenectomy
Howell Jolly bodies
G6PD
Porphyrias
Off center nuclues - clock face chromatin
34. What is the receptor for vWF
B symptoms - fever night sweats - weight loss
Lung disease - congenital heart diseaes - and high altitude
Inc HbA2 on electrophoresis
Gp1b
35. What is the philadelphia chromosome
TXA2 - dec blood flow - inc platelet aggregation
Multiple myeloma
T(9;22) bcr abl
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
36. What is the most common hodgkin lymphoma
Positive osmootic fragility test and splenectomy
Inc HbF and dec HbS
Nodular sclerosing
TRAP (tartrate resistant acid phosphatase
37. Serum iron - transferrin - ferritin lab values for hemochromatosis
Factor V resistant to activated protein C's inhibition
Yes - via MHC II
Up - down - up
Hb Barts - gamma4 in defect in all 4 alpha genes
38. CD5+ - poor prognosis - t(11;14)
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
Mantle cell - older males
VWD
Bone marrow - thymus - blood (80% of circulating lymphos are T)
39. Ddx for microcytic anemia
Lung disease - congenital heart diseaes - and high altitude
Low O2 in papilla; can also get microhematuria from medullary infarcts
Gp1b
Fe def - thal - pb poison - sideroblastic anemia
40. What vitamin is a cofactor for the first step of heme synthesis
Blasts > 5%
B6
Dec plasma volume
Bite cells and Heinz bodies
41. What do the iron studies show in sideroblastic anemia
DIC - TTP/HUS - traumatic hemolysis
Off center nuclues - clock face chromatin
Inc serum iron - normal TIBC - inc ferratin
ATIII def
42. Deficiency in GpIb
Bernard soulier
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Liver disease - abetalipoproteinemia - acntho = spiny
Dec synthesis of factors 1972 - protein C/S
43. t(11;14)
Mantle cell lymphoma
Leukemoid reaction
Adult T cell lymphoma - presents with cutaneous lesions
Dendritic cells?
44. What do the platelets bind? What is the step called
Bite cells and Heinz bodies
They bind vWF via GpIb
Ticlopidine/clopidogrel
Positive osmootic fragility test and splenectomy
45. What happens in betal thal minor?
Splicing sites and promotor sequences
Beta chain underproduced - asymptomatic - heterozygote
IgG - Warm is GREAT
GpIIb/IIIa
46. Bite cell
G6PD
No
Glycine and succinyl - coa
Folate def
47. What does the blood smear show in glanzmann's?
Blasts > 5%
Intravascular
Ankryin - band 4.1 or spectrin
No platelet clumping
48. Eosinophils are highly phagocytic For what kind of complex?
Antigen - antibody
Schistocytes - helmet cells
Bone marrow - thymus - blood (80% of circulating lymphos are T)
120 days
49. How does vWD cause elevated PTT?
Megakaryocytes
VWF carries/protects factor VIII
Langerhans cells
Helps platelts adhere to endothelium
50. What are the etiologies of B12 def
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
Polycythemia vera
G6PD
Degrades fibrin mesh and converts C3 to C3a
Sorry!:) No result found.
Can you answer 50 questions in 15 minutes?
Let me suggest you:
Browse all subjects
Browse all tests
Most popular tests
Major Subjects
Tests & Exams
AP
CLEP
DSST
GRE
SAT
GMAT
Certifications
CISSP go to https://www.isc2.org/
PMP
ITIL
RHCE
MCTS
More...
IT Skills
Android Programming
Data Modeling
Objective C Programming
Basic Python Programming
Adobe Illustrator
More...
Business Skills
Advertising Techniques
Business Accounting Basics
Business Strategy
Human Resource Management
Marketing Basics
More...
Soft Skills
Body Language
People Skills
Public Speaking
Persuasion
Job Hunting And Resumes
More...
Vocabulary
GRE Vocab
SAT Vocab
TOEFL Essential Vocab
Basic English Words For All
Global Words You Should Know
Business English
More...
Languages
AP German Vocab
AP Latin Vocab
SAT Subject Test: French
Italian Survival
Norwegian Survival
More...
Engineering
Audio Engineering
Computer Science Engineering
Aerospace Engineering
Chemical Engineering
Structural Engineering
More...
Health Sciences
Basic Nursing Skills
Health Science Language Fundamentals
Veterinary Technology Medical Language
Cardiology
Clinical Surgery
More...
English
Grammar Fundamentals
Literary And Rhetorical Vocab
Elements Of Style Vocab
Introduction To English Major
Complete Advanced Sentences
Literature
Homonyms
More...
Math
Algebra Formulas
Basic Arithmetic: Measurements
Metric Conversions
Geometric Properties
Important Math Facts
Number Sense Vocab
Business Math
More...
Other Major Subjects
Science
Economics
History
Law
Performing-arts
Cooking
Logic & Reasoning
Trivia
Browse all subjects
Browse all tests
Most popular tests