Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What is the pathogenesis of sickle cell
Howell - Jolly bodies - hypo/asplenia
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Howell Jolly bodies
Idiopathic thrombocytopenia (ITP)

2. What is the Ddx for for a macrocytic anemia
Histamine - heparin - and eosinohil chemotactic factors
Rhogam - Rh antigen immunoglobulin
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF

3. What substances are released in mast cell degranulation
Hodgkin
Histamine - heparin - and eosinohil chemotactic factors
Marrow - marrow - follicles of lymph nodes - white pulp of spleen (unencapsulated lymphoid tissue)
Hb Barts - gamma4 in defect in all 4 alpha genes

4. What are the neuro sx of B12 def?
Incactivates II - VII - IX - X - XI - XII
Antigen - antibody
All < 15 - AML = median onset around 60 - CML = 30 to 60 - and CLL > 60
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia

5. What does NAACP stand for - in regards to the causes of eosinophiia?
...
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
Protein C or S deficiency
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -

6. What is the clinical picture of hemophilia A or B
Macrohemorrhage - hemarthroses - easy bruising
Histamine - heparin - and eosinohil chemotactic factors
Reed - sternberg cells
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin

7. What is the effected enzyme in acute intermittment porphyria?
Gp1b
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Von Willebrand's disease
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)

8. What is the coombs test results in AIHA?
Mantle cell - older males
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
Pos
Hereditary spherocytosis - autoimmune hemolysis

9. Deficiency in GpIb
Beta chain underproduced - asymptomatic - heterozygote
Porphyrias
Bernard soulier
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -

10. What is the activation stage of platelet plug formation?
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
TRAP (tartrate resistant acid phosphatase
AB - no antibodies

11. What do platelets interact with to form a hemostatic plug
Dec plasma volume
Fibrinogen
Paraprotein spike - monoclonal protein
Erythroblastosis fetalis - Rh or other blood antigen incompatibility

12. Drug that inhibits COX and therefore TXA2 synthesis
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Aspirin
Liver disease - abetalipoproteinemia - acntho = spiny

13. Schisotcyte - helmet cell
Malnutrition - malabsoprtion - impaired metabolism - inc requirement as in an hemolytic anemia or pregnancy
Hereditary elloptocytosis
Lead - and EtOH
DIC - TTP/HUS - traumatic hemolysis

14. Elderly - mature b cell tumor with filamentous - hairlike projections
Hairy cell leukemia
Sickle cell anemia
Hereditary spherocytosis - autoimmune hemolysis
Follicular lymphoma - indolent course

15. What does hairy cell leukemia stain with
G6PD
Extravascular
TRAP (tartrate resistant acid phosphatase
Inc RBC - dec O2 sat - inc EPO

16. Macro - ovalocyte
Lung disease - congenital heart diseaes - and high altitude
Protoporphyrin (blood)
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
ATIII def

17. Can B cells function as APCs?
M3 AML (acute promyelocytic leukemia)
Yes - via MHC II
Ankryin - band 4.1 or spectrin
Blasts > 5%

18. RBCs damagaed from passing through obstructed - narrowed vessel lumina
All < 15 - AML = median onset around 60 - CML = 30 to 60 - and CLL > 60
MAHA
Up - down - up
Hereditary spherocytosis - autoimmune hemolysis

19. What is the characteristic lab finding on electrophoresis
Histamine - heparin - and eosinohil chemotactic factors
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Paraprotein spike - monoclonal protein
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning

20. How are the nucleus and the cytoplasm characterized for lymphocytes
Sickle cell anemia
AB - no antibodies
Blod - tissue - MACS
Round densly staining nucleus with a small amount of pale cytoplasm

21. Acanthocyte (spur cell)
Liver disease - abetalipoproteinemia - acntho = spiny
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Inactivates it
DIC

22. What do labs show in ITP?
5- FU - AZT - hydroxyurea
Hereditary spherocytosis
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT

23. anti - GpIIb/IIIa antibodies leading to peripheral platelet destruction
HIV or immunosupression
IgG - Warm is GREAT
Idiopathic thrombocytopenia (ITP)
Lacunar in nodular sclerosing variant

24. What substance is Fe added to to yield heme
Low O2 in papilla; can also get microhematuria from medullary infarcts
Protoporphyrin
Malaria - Babesia
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -

25. What does bradykinin do?
Schistocytes - helmet cells
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
Inc vasodiltion - inc perm - inc pain
They bind vWF via GpIb

26. What does plasmin do?
Incactivates II - VII - IX - X - XI - XII
Blasts > 5%
Degrades fibrin mesh and converts C3 to C3a
TRAP (tartrate resistant acid phosphatase

27. What is the receptor for vWF
G6PD
Blasts > 5%
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
Gp1b

28. adults - auer rods - inc circulating myeblasts on peripheral smear
AML
PGI2 - NO inc blood flow - dec platelet aggregation
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
G6PD

29. What does the blood smear show in glanzmann's?
Leukemia
Essential thrombocytosis
No platelet clumping
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis

30. Fibrotic obliteration of bone marow with teardrop cells

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

31. Widespread activation of clotting to a deficiency in clotting factors which causes a bleeding states
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
CML
DIC

32. What is the purpose of the fibrin mesh
Low O2 in papilla; can also get microhematuria from medullary infarcts
Acts to stabilize platelet plug
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis
Heinz bodies - seen in alpha thal and G6PD

33. What is the pathogenesis of ACD?
Positive osmootic fragility test and splenectomy
CNS and testis
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Imatinib - anti bcr abl

34. inc LDH - jaundice
Cromolyn sodium
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
Anti Rh
Extravascular hemolysis

35. Oxidation of iron - denatured hemoglobin preceipitation damage to RBC membrane - formation of bite cells
Heinz bodies - seen in alpha thal and G6PD
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs

36. What activates the fibrinolytic pathway?
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
Blod - tissue - MACS
Lead - and EtOH
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin

37. Serum iron - transferrin - ferritin lab values for hemochromatosis
Ferrocheletase and ALA dehydrogenase
Both alpha and beta thal
Langerhans cell histiocytosis
Up - down - up

38. Marrow expansion - 'crew cut' on skull x ray - skeletal deformaties - and chipmunk faces
DIC - TTP/HUS - traumatic hemolysis
Blistering cutaneous photosens - most common porphyria
HbSS
Beta thal

39. What does decreasing heme do to ALA synthase activity?
20 to 40
Inc RBC - dec O2 sat - inc EPO
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
Inc

40. What is the enzyme defect in Porphyria cutanea tarda
Complications of sickle cell anemia
Macrohemorrhage - hemarthroses - easy bruising
Uroporphyrinogen decarboxylase
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -

41. What substance prevents mast cells degranulation?
Von Willebrand's disease
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
Cromolyn sodium
SLE - CLL - alpha methyldopa

42. What is hemophiliia A
Essential thrombocytosis
Mantle cell lymphoma
Low in CML
Deficiency in factor VIII

43. Bone pain plus anemia
Collagen - BM - activated platelets
Multiple myeloma
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
IgG - Warm is GREAT

44. hemolytic in a newborn - dec ATP and rigid RBCs
Off center nuclues - clock face chromatin
Pyruvate kinase def - extravascular
CLL (SLL without the peripheral lymphocytosis
Hereditary spherocytosis - autoimmune hemolysis

45. deficiency in ADAMTS13 leading to dec degradation of vWF
Blasts > 5%
Both alpha and beta thal
Decrease EPO
Thrombotic thrombocytopenic purpura

46. inc WBC count with left shift - inc leukocyte alkaline phosphatase - often due to infection
Leukemoid reaction
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Peroxidase
Heinz bodies - seen in alpha thal and G6PD

47. CD5+ - poor prognosis - t(11;14)
Aspirin
B6
Leukemia
Mantle cell - older males

48. What are the pro aggregation factors?
TXA2 - dec blood flow - inc platelet aggregation
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Positive osmootic fragility test and splenectomy
Induces differentiation of myeloblasts

49. What is the characteristic spread of Hodgkin Lymphoma
Nodular sclerosing
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Contiguous

50. What is the affected enzyme in acute intermittment porphyria
ADP and Ca
Orotic aciduria
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Porphobilinogen - delta ALA - uroporphyrin

Sorry!:) No result found.

Can you answer 50 questions in 15 minutes?

Major Subjects
Tests & Exams AP CLEP DSST GRE SAT GMAT	Certifications CISSP go to https://www.isc2.org/ PMP ITIL RHCE MCTS More...	IT Skills Android Programming Data Modeling Objective C Programming Basic Python Programming Adobe Illustrator More...	Business Skills Advertising Techniques Business Accounting Basics Business Strategy Human Resource Management Marketing Basics More...
Soft Skills Body Language People Skills Public Speaking Persuasion Job Hunting And Resumes More...	Vocabulary GRE Vocab SAT Vocab TOEFL Essential Vocab Basic English Words For All Global Words You Should Know Business English More...	Languages AP German Vocab AP Latin Vocab SAT Subject Test: French Italian Survival Norwegian Survival More...	Engineering Audio Engineering Computer Science Engineering Aerospace Engineering Chemical Engineering Structural Engineering More...
Health Sciences Basic Nursing Skills Health Science Language Fundamentals Veterinary Technology Medical Language Cardiology Clinical Surgery More...	English Grammar Fundamentals Literary And Rhetorical Vocab Elements Of Style Vocab Introduction To English Major Complete Advanced Sentences Literature Homonyms More...	Math Algebra Formulas Basic Arithmetic: Measurements Metric Conversions Geometric Properties Important Math Facts Number Sense Vocab Business Math More...	Other Major Subjects Science Economics History Law Performing-arts Cooking Logic & Reasoning Trivia

Test your basic knowledge |

Hemeonc

Sorry!:) No result found.

Can you answer 50 questions in 15 minutes?

Let me suggest you:

Browse all subjects

Browse all tests

Most popular tests

Major Subjects

Tests & Exams

Certifications

IT Skills

Business Skills

Soft Skills

Vocabulary

Languages

Engineering

Health Sciences

English

Math

Other Major Subjects

Browse all subjects

Browse all tests

Most popular tests