Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Eosinophils are highly phagocytic For what kind of complex?
Inducers of primary antibody response
Antigen - antibody
Fibrinogen bind GpIIb/IIIa and links platelts
Complications of sickle cell anemia

2. drug that inhibits ADP induced expression of GpIIb/IIIa
Complications of sickle cell anemia
Ticlopidine/clopidogrel
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
Down - down - up

3. What causes the jaundice in extravascular hemolysis
Hereditary spherocytosis
Von Willebrand's disease
Inc UCB
Bleeding - malnutrition/absorption - inc demand pregs

4. Elliptocyte
Megakaryocytes
Multiple myeloma
Birbeck granules
Hereditary elloptocytosis

5. t(15;17)
Thrombotic thrombocytopenic purpura
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
M3 AML (acute promyelocytic leukemia)
Easy gas exchange

6. What substances are released in mast cell degranulation
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT
Histamine - heparin - and eosinohil chemotactic factors
HbSS
No

7. What vitamin is a cofactor for the first step of heme synthesis
Nl PT - elevated PTT - intrinsic pathway defect
20 to 40
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
B6

8. Which maternal antibodies cross the placenta - anti A/B or anti Rh
Dec
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Dec plasma volume
Anti Rh

9. What is the mutation in HbC
Lysine for glutamate at position 6
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
EBV
Hydroxyurea - bone marrow transplant

10. deficiency in ADAMTS13 leading to dec degradation of vWF
Orotic aciduria
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
Thrombotic thrombocytopenic purpura
Bleeding - malnutrition/absorption - inc demand pregs

11. How are the nucleus and the cytoplasm characterized for lymphocytes
Malaria - Babesia
Round densly staining nucleus with a small amount of pale cytoplasm
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
VWD

12. Oxidation of iron - denatured hemoglobin preceipitation damage to RBC membrane - formation of bite cells
Blod - tissue - MACS
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
Beta 4
Heinz bodies - seen in alpha thal and G6PD

13. Fava beans - sufla drugs - infectinos
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
Examples of oxidative stress
Induces differentiation of myeloblasts
CNS and testis

14. What percentage of WBCs are monocytes?
2 to 10
CD15 and CD30 pos
Collagen - BM - activated platelets
Bone marrow - thymus - blood (80% of circulating lymphos are T)

15. What virus is associated with Burkitt lymphoma
Blod - tissue - MACS
EBV
Langerhans cells
Pyruvate kinase def - extravascular

16. What symptoms are associated with Hodgkin lymphoma
Diffuse Large b cell lymphoma
B symptoms - fever night sweats - weight loss
Fibrinogen bind GpIIb/IIIa and links platelts
B12 in fatty acid pathways leads to subacute combined degeneration

17. adults - auer rods - inc circulating myeblasts on peripheral smear
AML
Protoporphyrin (blood)
Protoporphyrin
Blood

18. What virus can cause an aplastic crisis in pts with HS?
Up - down - nl
CML to AML or All
Parvovirus
Pyruvate kinase def - extravascular

19. universal recipient
HbSS
G6PD
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites
AB - no antibodies

20. What is the tx for vWD
Parvovirus
Marrow - marrow - follicles of lymph nodes - white pulp of spleen (unencapsulated lymphoid tissue)
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -

21. Drug that inhibits COX and therefore TXA2 synthesis
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
Splicing sites and promotor sequences
EBV
Aspirin

22. What condition can result from treating AML M3 from the release of the Auer rods
Lacunar in nodular sclerosing variant
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
DIC
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO

23. inc WBC count with left shift - inc leukocyte alkaline phosphatase - often due to infection
Hb Barts - gamma4 in defect in all 4 alpha genes
HIV or immunosupression
Ferrocheletase and ALA dehydrogenase
Leukemoid reaction

24. Schisotcyte - helmet cell
Petechiae
Bone marrow - thymus - blood (80% of circulating lymphos are T)
DIC - TTP/HUS - traumatic hemolysis
Langerhans cell histiocytosis

25. Where do you see hypersegmented polys?
Bone marrow - thymus - blood (80% of circulating lymphos are T)
All trans retinoic acid
Ankryin - band 4.1 or spectrin
B12/folate def

26. What is the pathogenesis of sickle cell
VWF carries/protects factor VIII
Antigen - antibody
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Lung disease - congenital heart diseaes - and high altitude

27. Which factor does vWF carry/protect
VIII
Inc large vWF multimers - inc platelet aggregation and thrombosis
Cromolyn sodium
Round densly staining nucleus with a small amount of pale cytoplasm

28. What do labs show in DIC?
Schistocytes - inc fibrin split products (D- dimers) - dec fibrinogen - dec factors V and VIII
Protein C or S deficiency
Fibrinogen
40 to 75

29. Production of mutant factor V that cannot by degraded by protein C - most common cause of inherited hypercoaguability
Factor V Leiden
Fc
Aplastic anemia - pancytopenia
Ticlopidine/clopidogrel

30. What are the extrinsic hemolytic normocytic anemias?
Thrombotic thrombocytopenic purpura
Factor V resistant to activated protein C's inhibition
...
Inducers of primary antibody response

31. What are the age ranges for the various leukemias
All < 15 - AML = median onset around 60 - CML = 30 to 60 - and CLL > 60
Her next Rh+ fetus
T(12;21)
Intravascular hemolysis

32. What are the pro aggregation factors?
ATIII def
Megakaryocytes
Inc serum iron - normal TIBC - inc ferratin
TXA2 - dec blood flow - inc platelet aggregation

33. Bone pain plus anemia
Inappropriate absolute with inc RBCs and EPO
Inc lymphoctes - and less RS cells
Multiple myeloma
B6

34. What level of leukocyte alkaline phosphatase is expected in CML versus leukemoid reaction
Positive osmootic fragility test and splenectomy
Essential thrombocytosis
Acts to stabilize platelet plug
Low in CML

35. What happens in betal thal minor?
Beta chain underproduced - asymptomatic - heterozygote
CML to AML or All
Factor V resistant to activated protein C's inhibition
Def in factor IX

36. Impaired synthesis of DAF leading to inc complement mediated desctruction of RBCs via the GPI ancho
Hydroxyurea - bone marrow transplant
Paroxysmal nocturnal hemoglobinuria
Sheets of lymphocytes interspersed with macs
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface

37. Teardrop cell
Rhogam - Rh antigen immunoglobulin
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Bone marrow infiltration - myelofibrosis
EBV

38. CD5+ - poor prognosis - t(11;14)
Pyruvate kinase def - extravascular
Mantle cell - older males
Blasts > 5%
Histaminase and arylsulfatase

39. What does STOP Making New Thrombi stand for
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Decrease EPO
Glanzmann's throbmasthenia

40. Blood type A
Multiple myeloma
Cromolyn sodium
A antigen and B antibodies
Fibrinogen bind GpIIb/IIIa and links platelts

41. Deficiency in GpIIb/IIIa

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

42. What do auer rods stain with
Peroxidase
VWF carries/protects factor VIII
CML to AML or All
Bone marrow - thymus - blood (80% of circulating lymphos are T)

43. Serum iron - transferrin - ferritin lab values for anemia of chronic disease
No platelet clumping
TPA - cleavage of fibrin mesh
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
Down - down - up

44. hypocellular bone marrown tih fatty infiltration
Paraprotein spike - monoclonal protein
Positive osmootic fragility test and splenectomy
Aplastic anemia - pancytopenia
Beta chain underproduced - asymptomatic - heterozygote

45. iron deficiency anemia - esophageal web - atrophic glossitis
Hairy cell leukemia
Plummer - vinson syndrome
Thrombotic thrombocytopenic purpura
Inc HbA2 on electrophoresis

46. What percentage of WBCs are eosinophils?
1 to 6
Leukemia
Liver disease - abetalipoproteinemia - acntho = spiny
Valine for glutamate

47. What are the likely exposures of kids and adults for lead poisoning
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
VWD
Valine for glutamate
Kids= exposure to lead paint - adults = battery - ammunition factory

48. What causes the physiologic chloride shift and What does the chloride shift do?
Inc vasodiltion - inc perm - inc pain
Inactivates it
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
B6 therapy (pyrodixine)

49. What portion of IgE can mast cells bind
Schistocytes - helmet cells
Fc
Prothrombin gene mutation
Dec plasma volume

50. What are some causes of warm agglutinin autoimmune hemolytic anemia?
SLE - CLL - alpha methyldopa
20 to 40
They bind vWF via GpIb
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis