Test your basic knowledge |

Hemeonc

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Intrinsic pathway coagulation defect and defect in platelet plug formation - most common inherited bleeding disorder - AD
Signs and sx of aplastic anemia
Extravascular
Tissue factor converst the VII and VIIa
VWD

2. What is the Ddx for a normocytic - normochromic anemia?
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
Hairy cell leukemia
Indirect coombs - agglutinate if serum anti RBC surface Ig
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis

3. What substance accumulates in porphyria cutanea
Histaminase and arylsulfatase
Uroporphyrin (tea colored urine)
Glycine and succinyl - coa
Anti Rh

4. Inherited deficiency of antithrombin; reduced inc in PTT after administration of heparin
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
ATIII def
Glanzmann's throbmasthenia
PENTAD: neurologic sx - renal sx - fever - thrombocytopenia - MAHA

5. What are some causes of warm agglutinin autoimmune hemolytic anemia?
Dec plasma volume
AML
Nl PT - elevated PTT - intrinsic pathway defect
SLE - CLL - alpha methyldopa

6. Aplastic crisis after parvovirus - autosplenectomy - salmonella osteomyelitis - painful crisis - renal papillary necrosis - splenic sequestration
Complications of sickle cell anemia
Leukemia
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Lymphoma

7. What is the presenting scenario for TTP?
MGUS - monoclonal gammopathy of undetermined significance
PENTAD: neurologic sx - renal sx - fever - thrombocytopenia - MAHA
T(12;21)
Fibrinogen

8. What happens in beta thal major?
Aplastic anemia - pancytopenia
MAHA
B cells
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis

9. What do auer rods stain with
CML
Peroxidase
Lung disease - congenital heart diseaes - and high altitude
Porphobilinogen deaminase aka uroporphyrinogen I synthase

10. RBCs damagaed from passing through obstructed - narrowed vessel lumina
MAHA
20 to 40
Blod - tissue - MACS
Positive osmootic fragility test and splenectomy

11. tennis rackets on EM
Peroxidase
Burkitt lymphoma
Lymphoma
Birbeck granules

12. Megakaryocytosis
B antigena and A antibodes
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
40 to 50
Essential thrombocytosis

13. What percentage of WBCs are basophils - and What is found in their basophilic granules?
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Fc
Pos
Lysosomes

14. What is the age group most commonly affected by multiple myeloma
Parvovirus
Allogenic bone marrow transplant - RBC/platelet transfusion - C- GSF - or GM- CSF
40 to 50
Inc vasodiltion - inc perm - inc pain

15. Defect in platelet to platelet adhesion - receptor - disorder - platelet count and bleeding time

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

16. Macro - ovalocyte
Collagen - BM - activated platelets
Myelofibrosis (marow is crying being its fibrosed'
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Neoplastic - asthma - allergic processes - collagen vacsular disease - parasites

17. Spherocyte
Langerhans cell histiocytosis
No antigen - both antibodies
Hereditary spherocytosis - autoimmune hemolysis
Histaminase and arylsulfatase

18. What does STOP Making New Thrombi stand for
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
DNA synth impaired - maturation of nucleus delayed relative to maturation of cytoplasm
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion

19. What virus is associated with 50% of Hodgkin lymphoma
DIC
EBV
Inc UCB
Porphyrias

20. What is HbH
Beta 4
Thrombotic thrombocytopenic purpura
Blood
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis

21. Where does All spread
Indirect coombs - agglutinate if serum anti RBC surface Ig
Orotic aciduria
Hydroxyurea - bone marrow transplant
CNS and testis

22. t(15;17)
M3 AML (acute promyelocytic leukemia)
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
Tissue
Lacunar in nodular sclerosing variant

23. What are the etiologies of B12 def
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead
Examples of oxidative stress
Complications of sickle cell anemia

24. Oxidation of iron - denatured hemoglobin preceipitation damage to RBC membrane - formation of bite cells
TPA - cleavage of fibrin mesh
Africa = Jaw lesion - US = pelvis or abdomen
Ankryin - band 4.1 or spectrin
Heinz bodies - seen in alpha thal and G6PD

25. anisocytosis
VWF carries/protects factor VIII
Varying sizes
B cells
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin

26. What distinguishes multiple myeloma fromk Waldenstroms macroglobulinemia?
AB - no antibodies
No lytic bone lesions in WM
Hb Barts - gamma4 in defect in all 4 alpha genes
Bleeding - malnutrition/absorption - inc demand pregs

27. S-100 and CD1a with birbeck granules
Langerhans cell histiocytosis
Cold - seen in CLL - mycoplasma pneumoniae infections or infectious mononucleosis
Megakaryocytes
DDAVP (desmopressin) which releases stored vWF stored in endothelium

28. What is the therapy for CML (philly chrom)
Imatinib - anti bcr abl
B cells
Mycosis fundgoides/Sezary syndrome
Cromolyn sodium

29. Back pain - hemoglobinuria
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Inc
Cromolyn sodium
Common a few days after oxidative stress in a pt with G6PD

30. Schisotcyte - helmet cell
Intrinsic - all factors except - VII - XIII
Langerhans cells
DIC - TTP/HUS - traumatic hemolysis
Up - down - up

31. What is the main source of energy in RBCs
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
Parvovirus
90% anearobically from glucose to lactate - 10% from HMP shunt
Essential thrombocytosis

32. Drug that inhbits the GpIIb/IIIa directly
Abciximab
Ankryin - band 4.1 or spectrin
CML
Protoporphyrin

33. What does ectopic EPO produce
Hereditary spherocytosis - G6PD - sickle cell
Degrades fibrin mesh and converts C3 to C3a
Protein C or S deficiency
Inappropriate absolute with inc RBCs and EPO

34. Which immunoglobulin is involved in warm agglutination?
Factor V resistant to activated protein C's inhibition
Antigen - antibody
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
IgG - Warm is GREAT

35. Impaired synthesis of DAF leading to inc complement mediated desctruction of RBCs via the GPI ancho
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Mantle cell lymphoma
Paroxysmal nocturnal hemoglobinuria
Down - down - up

36. What does antithrombin do and What activates it?
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Protoporphyrin
Dec
Spleen

37. discrete tumor masses arising from lymph nodes
Sideroblastic anemia
Birbeck granules
Uroporphyrin (tea colored urine)
Lymphoma

38. inc LDH - jaundice
AB - no antibodies
Extravascular hemolysis
Sideroblastic anemia
Multiple myeloma

39. normal RBCs added to patient's serum
Bleeding - malnutrition/absorption - inc demand pregs
Mantle cell lymphoma
Indirect coombs - agglutinate if serum anti RBC surface Ig
Malaria - Babesia

40. What is their role?
EBV
Heinz bodies - seen in alpha thal and G6PD
Inducers of primary antibody response
90% anearobically from glucose to lactate - 10% from HMP shunt

41. What does ADP do?
Varying sizes
Helps platelts adhere to endothelium
40 to 50
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead

42. Blood type B
Petechiae
Lysine for glutamate at position 6
B antigena and A antibodes
Incactivates II - VII - IX - X - XI - XII

43. What happens in betal thal minor?
Indirect coombs - agglutinate if serum anti RBC surface Ig
Beta chain underproduced - asymptomatic - heterozygote
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis
B6 therapy (pyrodixine)

44. What is the are the presenting symptoms of lead poisoning in kids and adults
Inc
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
ATIII def
Inc RBC - dec O2 sat - inc EPO

45. hypocellular bone marrown tih fatty infiltration
DNA synth impaired - maturation of nucleus delayed relative to maturation of cytoplasm
Aplastic anemia - pancytopenia
Beta chain absent - homozgote - severe anemia requiring blood transfusion - secondary hemochromatosis
ADP and Ca

46. What is the ddx for aplastic anemia

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

47. What substance is Fe added to to yield heme
Splicing sites and promotor sequences
Beta chain underproduced - asymptomatic - heterozygote
Beta 4
Protoporphyrin

48. What are the pro aggregation factors?
Protoporphyrin
Varying shapes
B12/folate def
TXA2 - dec blood flow - inc platelet aggregation

49. Target cell

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

50. What role does antithrombin play?
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
Aplastic anemia - pancytopenia
Inappropriate absolute with inc RBCs and EPO
Incactivates II - VII - IX - X - XI - XII