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Test your basic knowledge |
Hemeonc
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. X linked - dec glutathione inc RBC susceptibility to oxidative stress
Fc
Exposed collagen upon endothelial damage
Africa = Jaw lesion - US = pelvis or abdomen
G6PD
2. What is the characteristic lab finding on electrophoresis
Paraprotein spike - monoclonal protein
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Inc suscept to infxn - primary amyloidosis - punched out lytic bone lesions - M spike - Ig light chains in urine - Rouleaud formations (stacked RBCs)
Hereditary spherocytosis - autoimmune hemolysis
3. Target cell
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4. t(11:22)
B12 in fatty acid pathways leads to subacute combined degeneration
VWF carries/protects factor VIII
Ewing sarcoma
Inappropriate absolute with inc RBCs and EPO
5. What substance is Fe added to to yield heme
Protoporphyrin
Ticlopidine/clopidogrel
Mantle cell - older males
Helps platelts adhere to endothelium
6. What is the affected enzyme in acute intermittment porphyria
Hairy cell leukemia
Produce antibody - lots of RER and golgi
Porphobilinogen - delta ALA - uroporphyrin
Porphobilinogen deaminase aka uroporphyrinogen I synthase
7. discrete tumor masses arising from lymph nodes
Lymphoma
Beta chain underproduced - asymptomatic - heterozygote
B6 therapy (pyrodixine)
Complications of sickle cell anemia
8. What is the therapy for CML (philly chrom)
Ringed sideronblasts with iron laden mitochondria
Antigen - antibody
Imatinib - anti bcr abl
T(9;22) bcr abl
9. Ddx for microcytic anemia
AB - no antibodies
Fe def - thal - pb poison - sideroblastic anemia
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Varying sizes
10. When do you see MAHA?
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
PENTAD: neurologic sx - renal sx - fever - thrombocytopenia - MAHA
Down - up - down
11. What is the therapy for the M3 variant?
5- FU - AZT - hydroxyurea
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
Hodgkin
All trans retinoic acid
12. hypersegmented PMNs - glossitis - dec folate - inc homocysteine - nl methylmalonic acid
Splicing sites and promotor sequences
Folate def
40 to 50
B12 in fatty acid pathways leads to subacute combined degeneration
13. What happens in betal thal minor?
Paraprotein spike - monoclonal protein
Splicing sites and promotor sequences
Beta chain underproduced - asymptomatic - heterozygote
Lead - and EtOH
14. What do platelets release necessary for coagulation cascaed?
ADP and Ca
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Signs and sx of aplastic anemia
Porphobilinogen - delta ALA - uroporphyrin
15. What virus is associated with Burkitt lymphoma
EBV
VWF and fibrinogen
B6 therapy (pyrodixine)
Sideroblastic anemia
16. What are some causes of cold agglutinin anemia
VWF and fibrinogen
Cold - seen in CLL - mycoplasma pneumoniae infections or infectious mononucleosis
Acts to stabilize platelet plug
B12/folate def
17. Deficiency in GpIIb/IIIa
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18. inc LDH - jaundice
Extravascular hemolysis
HyperCalcemia - Renal insuff - Anemia - Bone lytic lesions/Back pain
Myelofibrosis (marow is crying being its fibrosed'
Fe def - thal - pb poison - sideroblastic anemia
19. What does ectopic EPO produce
Aspirin
Inappropriate absolute with inc RBCs and EPO
Varying shapes
Bite cells and Heinz bodies
20. Macro - ovalocyte
1 to 6
CLL (SLL without the peripheral lymphocytosis
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
Adult T cell lymphoma - presents with cutaneous lesions
21. drug that inhibits ADP induced expression of GpIIb/IIIa
Protoporphyrin
Lead lines on gingivae and epiphyses of long bones on xray - Encephalopathy and Erythrocyte basophilic stippling - Abdominal colic and Anemia - Drops - wrist and foot drop -
Ticlopidine/clopidogrel
1 to 6
22. Plasma cell neoplasm
Glanzmann's throbmasthenia
Both alpha and beta thal
Anemia of chronic disease - Aplastic anemia - kidney disease
Multiple myeloma
23. mother's antibodies attack fetal RBCs
Up - down - nl
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
Bernard soulier
Erythroblastosis fetalis - Rh or other blood antigen incompatibility
24. What symptoms are associated with Hodgkin lymphoma
Inappropriate absolute with inc RBCs and EPO
Abciximab
B symptoms - fever night sweats - weight loss
Pyruvate kinase def - extravascular
25. What is the tx for vWD
Antigen - antibody
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Folate/B12 - nonmegaoblastic anemias - liver dz - EtOH (non folate/B12) reticulocytosis - metabolic disorder - drugs
G6PD
26. What percentage of WBCs are eosinophils?
Tissue
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
1 to 6
Inc vasodiltion - inc perm - inc pain
27. Ringed sideroblasts
Sideroblastic anemia
Birbeck granules
Ewing sarcoma
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
28. What substance prevents mast cells degranulation?
AML
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
Leukemoid reaction
Cromolyn sodium
29. Which enzyme converts vit k to activated vit k - and what substance inhibits this enzyme
Direct coombs - agglutinate if RBCs are coated with Ig
Sheets of lymphocytes interspersed with macs
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
Epoxide reductase - warfarin inhibits
30. HTLV-1
Collagen - BM - activated platelets
Hodgkin
Inappropriate absolute with inc RBCs and EPO
Adult T cell lymphoma - presents with cutaneous lesions
31. Does CML have a JAK2 mut
No
B symptoms - fever night sweats - weight loss
Sickle cell anemia
Langerhans cells
32. philadelphia chromosome - blood looks like marrow
Schistocytes - helmet cells
Varying shapes
HbC disease - Asplenia - Liver disease - thalassemia - 'HALT the hunter said to his target'
CML
33. What is the mutation in HbC
Lysine for glutamate at position 6
Alpha thal - asian and african american
Inc serum iron - normal TIBC - inc ferratin
VWD
34. What do the labs show for TTP?
MGUS - monoclonal gammopathy of undetermined significance
AB - no antibodies
Schistocytes and inc LDH
Peripheral neuropathy - posterior columns (vibration/proprioception) - lateral corticospinal (spasticity) - dementia
35. What is the Ddx for nonhemolytic normocytic anemia
...
TAIL - thalassemias - anemia of chronic disease - iron def - lead poisoning
Bimodal - men>women - except for nodular sclerosing type
Anemia of chronic disease - Aplastic anemia - kidney disease
36. Which lymphoma is characterized by localized involvement with a single group of nodes and mediastinal lymphadenopathy
DIC - TTP/HUS - traumatic hemolysis
Parvovirus
Hodgkin
All
37. Conditions of defective heme synthesis leading to accumulation of heme precurors
1 to 6
Schistocytes and inc LDH
Burkitt lymphoma
Porphyrias
38. inc HbF on electrophoresis
Prothrombin gene mutation
Blistering cutaneous photosens - most common porphyria
Glycine and succinyl - coa
Both alpha and beta thal
39. What is contained within the azurophilic granules of PMNs
Collagen - BM - activated platelets
Hydrolytic enzymes - lysozyme - myeloperoxidase - lactoferrin
Degrades fibrin mesh and converts C3 to C3a
Petechiae
40. What does ADP do?
Helps platelts adhere to endothelium
Yes - via MHC II
Burkitt lymphoma
Hereditary spherocytosis
41. poikilocytosis
Abciximab
Easy gas exchange
Hereditary spherocytosis
Varying shapes
42. What does plasmin do?
Degrades fibrin mesh and converts C3 to C3a
Langerhans cell histiocytosis
CNS and testis
Sickle cell
43. What are the etiologies of folate def
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
Malnutrition - malabsoprtion - impaired metabolism - inc requirement as in an hemolytic anemia or pregnancy
Macrohemorrhage - hemarthroses - easy bruising
Imatinib - anti bcr abl
44. What is the coombs test results in AIHA?
Fc
DIC
Pos
Down - up - down
45. dec haptoglobin - inc LDH - hemoglobin in urine (paroxysmal nocturnal hemoglobinuria - mechanical destruction as in aortic stenosis or a prosthetic valve
Essential thrombocytosis
Gp1b
VWF carries/protects factor VIII
Intravascular hemolysis
46. What portion of IgE can mast cells bind
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
Ringed sideronblasts with iron laden mitochondria
Fc
Sheets of lymphocytes interspersed with macs
47. Why can newborns with sickle cell be asymptomatic
Indirect coombs - agglutinate if serum anti RBC surface Ig
Sheets of lymphocytes interspersed with macs
Inc HbF and dec HbS
Inc HbA2 on electrophoresis
48. universal donor
No antigen - both antibodies
Epoxide reductase - warfarin inhibits
ADP binding to receptors causes upregulation of GpIIb/IIIa expression at platelet surface
5- FU - AZT - hydroxyurea
49. What do the iron studies show in sideroblastic anemia
Inc serum iron - normal TIBC - inc ferratin
Epoxide reductase - warfarin inhibits
B symptoms - fever night sweats - weight loss
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
50. What do auer rods stain with
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Yes - via MHC II
Blood
Peroxidase