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Hemeonc
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Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is the treatment for lead poising?
B6
VWD
B12 in fatty acid pathways leads to subacute combined degeneration
Dimercaprol and EDTA 1st line of treatment - succimer for kids - it sucks to be a kid who eats lead
2. t(11;14)
Mantle cell lymphoma
8-10 days
Hemolytic or non hemolytic - and then for the hemolytiuc - intravascular hemolysis or extravascular hemolysis
Cromolyn sodium
3. What distinguishes multiple myeloma fromk Waldenstroms macroglobulinemia?
Ewing sarcoma
Hodgkin
No lytic bone lesions in WM
TRAP (tartrate resistant acid phosphatase
4. What cell is primarily involved in non Hod lymph
Acts to stabilize platelet plug
Complications of sickle cell anemia
B cells
Sheets of lymphocytes interspersed with macs
5. Aplastic crisis after parvovirus - autosplenectomy - salmonella osteomyelitis - painful crisis - renal papillary necrosis - splenic sequestration
Bone marrow - thymus - blood (80% of circulating lymphos are T)
Complications of sickle cell anemia
Hodgkin
Leukemia
6. What does hairy cell leukemia stain with
TRAP (tartrate resistant acid phosphatase
CML to AML or All
Abciximab
EBV
7. Defect in platelet to platelet adhesion - receptor - disorder - platelet count and bleeding time
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8. Bone pain plus anemia
Howell - Jolly bodies - hypo/asplenia
Lung disease - congenital heart diseaes - and high altitude
Mycosis fundgoides/Sezary syndrome
Multiple myeloma
9. Where does All spread
Plummer - vinson syndrome
CNS and testis
Fc
IgG - Warm is GREAT
10. What do auer rods stain with
Peroxidase
Ferrocheletase and ALA dehydrogenase
Porphobilinogen - delta ALA - uroporphyrin
Up - down - up
11. What signal activates MACS
IFN gama
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
AML
Inappropriate absolute with inc RBCs and EPO
12. What is the treatment to prevent a woman from forming anti Rh antibody?
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
Rhogam - Rh antigen immunoglobulin
Leukemia
Nl - up - nl
13. What is the tx for sickle cell
Hydroxyurea - bone marrow transplant
PGI2 - NO inc blood flow - dec platelet aggregation
< 1% - heparin - histamine - LTD-4 - other vasoactive amines
Adult T cell lymphoma - presents with cutaneous lesions
14. What percentage if WBCs are polys?
Abciximab
Inc large vWF multimers - inc platelet aggregation and thrombosis
40 to 75
Her next Rh+ fetus
15. How does vWD cause elevated PTT?
Radiation/drugs - viral agents - fanconi's anemia - idiopathic may follow acute hepatitis
B antigena and A antibodes
Histamine - heparin - and eosinohil chemotactic factors
VWF carries/protects factor VIII
16. Wilm's tumor - RCC - HCC - hydronephrosis
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
Polycythemia vera with inc plasma volume - inc RBCs - inc EPO
Factor V resistant to activated protein C's inhibition
17. Serum iron - transferrin - ferritin lab values for pregs - OCP use
B12 in fatty acid pathways leads to subacute combined degeneration
Nl - up - nl
Collagen - BM - activated platelets
Parvovirus
18. What is the tx for vWD
DDAVP (desmopressin) which releases stored vWF stored in endothelium
Ticlopidine/clopidogrel
Factor V Leiden
Bleeding - malnutrition/absorption - inc demand pregs
19. What does antithrombin do and What activates it?
Collagen - BM - activated platelets
Inhibits thrombin - ixa - xa - xiia - and activated by heparin
Decrease EPO
Lung disease - congenital heart diseaes - and high altitude
20. poikilocytosis
Varying shapes
Von Willebrand's disease
Reed - sternberg cells
Porphyrias
21. Is G6PD intravascular or extravascular
Multiple myeloma
Petechiae
Bernard soulier
Intravascular
22. Acanthocyte (spur cell)
Produce antibody - lots of RER and golgi
Degrades fibrin mesh and converts C3 to C3a
Liver disease - abetalipoproteinemia - acntho = spiny
No
23. What do platelets interact with to form a hemostatic plug
Porphobilinogen deaminase aka uroporphyrinogen I synthase
Incactivates II - VII - IX - X - XI - XII
Fibrinogen
Sickle cell
24. Where are 1/3 of platelets stored
Spleen
Ticlopidine/clopidogrel
Pos
Alpha thal - asian and african american
25. inc HbF on electrophoresis
Porphyrias
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
Birbeck granules
Both alpha and beta thal
26. What are the likely exposures of kids and adults for lead poisoning
Acts to stabilize platelet plug
Histamine - heparin - and eosinohil chemotactic factors
EBV
Kids= exposure to lead paint - adults = battery - ammunition factory
27. What the alpha granules contain in platelets?
Varying sizes
M3 AML (acute promyelocytic leukemia)
Porphobilinogen - delta ALA - uroporphyrin
VWF and fibrinogen
28. What happens in betal thal minor?
Gp1b - bernard - soulier - dec platelets (giant platelets not counted) - inc BT
Down - up - down
Beta chain underproduced - asymptomatic - heterozygote
Inc bleeding time - microhemorrhage: mucuous membrane bleeding - epitaxis - petechiae - purpura - possible thrombocytopenia
29. Production of mutant factor V that cannot by degraded by protein C - most common cause of inherited hypercoaguability
Defect in 4 - not compatible with life - defect in 3 - HbH disease - defect in 1/2 not associated with sig anemia
Protein C or S deficiency
Decrease EPO
Factor V Leiden
30. Who has more severe disease - HbSS or HbSC
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
HbSS
Inc large vWF multimers - inc platelet aggregation and thrombosis
VWD
31. defect in alpha globin gene - dec alpha globin synth - disease and populations?
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
Down - up - down
Produce antibody - lots of RER and golgi
Alpha thal - asian and african american
32. What causes the physiologic chloride shift and What does the chloride shift do?
Chloride bicarb antiport system - - allows transport of C02 from periph to lungs
WBC diff highest to lowest: neutrophils - lymphocytes - monocytes - eosinophils - basophils
Causes of DIC: Sepsis (gram neg) - Trauma - Obstetric complications - acute Pancreatitis - Malignancy - Nephrotic syndrome - Tranfusion
Tissue
33. Macro - ovalocyte
Porphobilinogen deaminase aka uroporphyrinogen I synthase
CD15 and CD30 pos
Megaloblastic anemia (also hypersegmented PMNs - marrow failure)
No platelet clumping
34. What does decreasing heme do to ALA synthase activity?
Inc
Inappropriate absolute with inc RBCs and EPO
EBV
VIII
35. hypersegmented PMNs - glossitis - dec folate - inc homocysteine - nl methylmalonic acid
Glanzmann's throbmasthenia
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
Folate def
AML
36. What are the etiologies of B12 def
Induces differentiation of myeloblasts
Kidney - Gi - microcytic anemai in both - kids = mental retardation and adults = headache - memory loss - demyelination
Megakaryocytes
Insufficient intake as with strict vegans - malabsorption as in crohns - pernicious anemia - diphyllobothrium
37. What converts plasminogen to plasm and What does plasmin do?
XIIa activates kallikrein - which activates plasmin (and converts HMWK to bradykinin
Diffuse Large b cell lymphoma
TPA - cleavage of fibrin mesh
90% anearobically from glucose to lactate - 10% from HMP shunt
38. What is the age group most commonly affected by multiple myeloma
Antigen - antibody
CML to AML or All
40 to 50
Tissue
39. What is the characteristic lab finding on electrophoresis
Hereditary spherocytosis - autoimmune hemolysis
Paraprotein spike - monoclonal protein
Her next Rh+ fetus
B6
40. What is the life spance of a platelet?
ADP and Ca
Her next Rh+ fetus
HbSS
8-10 days
41. Back pain - hemoglobinuria
Fe def - thal - pb poison - sideroblastic anemia
Orotic aciduria
Common a few days after oxidative stress in a pt with G6PD
Thrombotic thrombocytopenic purpura
42. Upregulated growth of leukocytes in bone marro
Adult T cell lymphoma - presents with cutaneous lesions
Lung disease - congenital heart diseaes - and high altitude
Leukemia
Inc vasodiltion - inc perm - inc pain
43. Crew cut on skull xray due to marrow supression - 8% of AA population - single amino acid replacement in beta chain at position 6 - after a DNA point mutation
Schistocytes - helmet cells
Sickle cell
AB - no antibodies
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
44. Widespread activation of clotting to a deficiency in clotting factors which causes a bleeding states
B12/folate def
Eleveated PT - PTT
DIC
Dendritic cells?
45. What is the pathogenesis of sickle cell
Dec platelet survival and inc megakaryocytes - thrombocytopenia and inc BT
Hereditary spherocytosis - autoimmune hemolysis
Deoxygenated HbS polymerizes - low O2 or dehydration precipiates sickling - anemia and veno - occlusive disease
Dec synthesis of factors 1972 - protein C/S
46. bcl -2 t(14;18) adults
Down - up - down
Bone marrow infiltration - myelofibrosis
DIC - TTP- HUS - SLE malignant HTN - prostethic heart valves - aortic stenosis
Follicular lymphoma - indolent course
47. What do they express on their surface?
Blod - tissue - MACS
MHC II and Fc receptors
Painful abdomen (also in lead poisoning) - red wine colored urine - polyneuropathy - psychological distrubances - precipated by drugs -
40 to 75
48. what proteins can be defective in HS?
Bleeding - malnutrition/absorption - inc demand pregs
Ankryin - band 4.1 or spectrin
...
All
49. adults - auer rods - inc circulating myeblasts on peripheral smear
CLL (SLL without the peripheral lymphocytosis
AML
Multiple - peripheral nodes - extranodal involvement - noncontiguous spread
M3 AML (acute promyelocytic leukemia)
50. Which enzyme converts vit k to activated vit k - and what substance inhibits this enzyme
Produce antibody - lots of RER and golgi
Inc HbA2 on electrophoresis
Epoxide reductase - warfarin inhibits
Inflammation leads to inc hepcidin causing a dec in release from iron from macs: dec serum fe - dec TIBC - inc ferritin
Sorry!:) No result found.
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