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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Major shift minor drift
CD14
IgG

2. What do superantigens do?
SLE
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Primary biliary cirrohosis

3. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
Neisseria bacteremia
DiGeorge
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

4. Which immunoglobulin is a pentamer
Hereditary angioedema
III
Superficial inguinal pectinate line
IgM

5. AR - defect in microtubule fxn with decreased phagocytosis
IL-12 - IFN- beta. IFN- alpha
Chediak Higashi
Mesenchyme
Fc

6. anti glutamate decarboxylase
Hereditary angioedema
Superficial inguinal pectinate line
IgA
DM type 1

7. What are the three APCs
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Signal 1 = APC - signal 2 = B7 and CD28
Macs - dendritic cell - B cell
Chronic: fibrosis of graft tissue and blood vessels

8. Which cell mediates the type IV hypersens rxn?
SLE - nonspecific
Prevents attachment of bacteria and viruses to mucous membranes
CD8 cells
IgG

9. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
Common variable immunodeficiency (CVID)
Mesenchyme
Chronic: fibrosis of graft tissue and blood vessels

10. thwat does the Right lymphatic duct drain?
Other vasculitidies
Drug induced lupus
Chronic mucocutaneaous candidiasis
Right arm and right half of head

11. antidesmoglein
DM type 1
Sjorgen's syndrome
CD21
Pemphigus vulgaris

12. Which type of hypersens rxn is serum sickness?
Chediak Higashi
Stomach
CD56
III

13. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
Regulates the humoral response
Bruton's agamma
I

14. Anti Scl 70 (DNA topo I
Hyper IgM
PMNs recruited by IL-8 to clear infxns
Chronic: fibrosis of graft tissue and blood vessels
Scleroderma diffuse

15. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IgG - IgM GM makes classic cars
IgG
RA

16. Which antibody mediates a type Hypersens rxn?
III
IgE
Pemphigus vulgaris
Ceilac disase

17. anti basement membrane
Other vasculitidies
All nucleated cells (no RBCs) A - B - C
Goodpastures
MHC I

18. What cytokines to Th2 cells secrete?
Hashimotos
Right arm and right half of head
Ceilac disase
IL-4 - 5 - 10

19. What are the cell surface receptors on MACS
Fc
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Regulates the humoral response
Il -4

20. HLA- DR5
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Regulates the humoral response
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Chediak Higashi

21. X linked recessive defect in BTK no B cell differentiation

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22. Cell surface receptors on B cels
Mixed connective tissue disease
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IFN gamma
Goodpastures

23. What is the clinical picture for serum sickness?
Chediak Higashi
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Signal 1 = APC - signal 2 = B7 and CD28
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

24. HLA- DR4
Stomach
Hemochromocytosis
RA - DM type 1
MHC I

25. What is the role of CD4 cels
Scleroderma CREST
All nucleated cells (no RBCs) A - B - C
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Help B cells make antibody - secrete IFN gamma to activate macs

26. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
IL-12 - IFN- beta. IFN- alpha
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
SCID
Stomach

27. Antihistone
Fc and Fab
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IV
Drug induced lupus

28. p - ANCA
DM type 1
Primary biliary cirrohosis
Other vasculitidies
B cell localization and proliferation

29. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Everything else - not right arm and right half of head
RA
Pemphigus vulgaris

30. antigliadin - antiendomysial
IgM
Ceilac disase
Poly/dermato myositis
IL-12 def

31. anti - Jo 1
CD56
Fc and Fab
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Poly/dermato myositis

32. Which type of hypersens rxn is immune complex mediate
Ceilac disase
Drug induced lupus
CD40 and CD40L
III

33. Which B T cell interaction allows for immunologic memory and class switching?
Hemochromocytosis
CD40 and CD40L
All nucleated cells (no RBCs) A - B - C
Steroid - responsive nephrotic syndrome

34. HLA- DR7
Neisseria bacteremia
Steroid - responsive nephrotic syndrome
C5b -9
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

35. Deficiency in DAF
IgG
Neisseria bacteremia
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

36. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
Primary biliary cirrohosis
IgG
Goodpastures

37. Defect in CD40L on helper T
Hyper IgM
Chronic mucocutaneaous candidiasis
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Steroid - responsive nephrotic syndrome

38. Which bacteria secrete superantigen
SLE
IL-4 - 5 - 10
S. aureus and S. pyogenes
Superficial inguinal pectinate line

39. c - ANCA
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Perforin - granzyme - granulysin
IL-12
Wegeners granulomatosis

40. Which cytokine induces Th2 cell profile in CD4 cells
Chediak Higashi
Il -4
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Sjorgen's syndrome

41. which areas of the body are drained by the celiac lymph node?
CD21
Stomach
Regulates the humoral response
Other vasculitidies

42. Antimitochondrial
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Howell - Jolly bodies - Target cells - thrombocytosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Primary biliary cirrohosis

43. Which receptor on MACS to endotoxin directy stimulate?
Major shift minor drift
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Common variable immunodeficiency (CVID)
CD14

44. How do CD8 cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Perforin - granzyme - granulysin
Sjorgen's syndrome
C3b

45. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Fc and Fab
Chediak Higashi
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

46. What are the 3 funxtions of antibodies?
Bruton's agamma
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Ceilac disase
Opsonization - neutralization and complement activation

47. Which is the receptors for EBV?
CD21
2
IgA
Pernicious anemia (to B12 def) - hashimotos thyroiditis

48. ANA
IL-12 - IFN- beta. IFN- alpha
Poly/dermato myositis
Right arm and right half of head
SLE - nonspecific

49. Where do positive and negative selection occur in the thymus?
Mixed connective tissue disease
Corticomedullary junction
IgG
RA - DM type 1

50. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IL-4 - 5 - 10
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn