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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which cytokines to Th1 cells secrete?
Stomach
2
IL-2 and IFN gamma
IFN gamma

2. X- linked recessive defect with progessive deletion of B and T cells
Wegeners granulomatosis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
S. aureus and S. pyogenes
Hyperacute : occlusion - ischemia - necrosis

3. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
MS - hay fever - SLE - goodpasture's
Goodpastures
RA - DM type 1

4. Which type of hypersens rxn is antibody mediated?
II
Hereditary angioedema
IgM
Right arm and right half of head

5. What is the unique cell marker for NK cells
Fc
CD56
Adaptive
Scleroderma diffuse

6. Which infections require administering passive immunity?
I
Opsonization - neutralization and complement activation
B cell localization and proliferation
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

7. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
Hashimotos
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Regulates the humoral response

8. Which parts of the antibody to light chain contribute
Chronic: fibrosis of graft tissue and blood vessels
Fab
Graves' dz
Scleroderma diffuse

9. which areas of the body are drained by the celiac lymph node?
Stomach
Bruton's agamma
IL-12 def
Scleroderma CREST

10. Which type of hypersens rxn is delayed
Signal 1 = APC - signal 2 = B7 and CD28
IV
III
RA

11. What is the difference in antigenic variation in viruses
Help B cells make antibody - secrete IFN gamma to activate macs
Bruton's agamma
Major shift minor drift
CD40 and CD40L

12. Defectin in isotype switching
Hashimotos
Selective Ig def - IgA most common
Mesenchyme
Poly/dermato myositis

13. What embryologic tissue are lymphcytes derived from
SLE
Mesenchyme
I
All nucleated cells (no RBCs) A - B - C

14. Defect in B cell maturation
Howell - Jolly bodies - Target cells - thrombocytosis
IgG
Common variable immunodeficiency (CVID)
IgG

15. What do mature B lymphos express on their surface?
IgM and IgD
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Fc

16. Defect in DNA repair enzymes
RA
Everything else - not right arm and right half of head
Ataxia telangectasia
Paracortex

17. Defect in CD40L on helper T
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IgA
Hyper IgM
I

18. antimicrosomal - antithyroglobulin
IL-4 - 5 - 10
PMNs recruited by IL-8 to clear infxns
Fab
Hashimotos

19. What happens in the follicle of the lymph node
B cell localization and proliferation
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Drug induced lupus

20. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Leukocyte adhesion deficiency type 1
Hyper IgM
Ceilac disase

21. What cytokines to Th2 cells secrete?
IL-4 - 5 - 10
Chronic granulomatous disease
IL-12 - IFN- beta. IFN- alpha
Hereditary angioedema

22. Deficiency in DAF
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Selective Ig def - IgA most common
IgE
SLE - nonspecific

23. which follicles (primary or secondary) have active germinal centers?
Sjorgen's syndrome
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Secondary
Howell - Jolly bodies - Target cells - thrombocytosis

24. Which complement proteins make up the MAC
C5b -9
MHC I
Steroid - responsive nephrotic syndrome
SCID

25. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
SCID
Hyper IgM
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

26. What does the thoracic duct drain?
Everything else - not right arm and right half of head
Fc
Secondary
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

27. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Hemochromocytosis
DiGeorge
DM type 1
CD8 cells

28. Anti Scl 70 (DNA topo I
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Secondary
Scleroderma diffuse

29. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
Pemphigus vulgaris
IL-2 and IFN gamma
Hyper IgE syndrome (Job's)

30. Which type of hypersens rxn is immune complex mediate
Wegeners granulomatosis
Upper limb and breast
IL-10
III

31. Which immunoglobulin is a pentamer
Hashimotos
IgM
RA - DM type 1
CD40 and CD40L

32. What inhibits Th2 cells
Scleroderma diffuse
IFN gamma
Ataxia telangectasia
Bruton's agamma

33. Antimitochondrial
Primary biliary cirrohosis
SCID
IL-12 def
Selective Ig def - IgA most common

34. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
Perforin - granzyme - granulysin
Hashimotos
Poly/dermato myositis

35. What is the clinical picture for serum sickness?
IgM
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Upper limb and breast
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

36. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Chediak Higashi
Fc and Fab
Pemphigus vulgaris

37. Which type of hypersens rxn is the arthus rxn
III
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IV
RA - DM type 1

38. anti basement membrane
I
Goodpastures
IgG
SLE

39. Which cell mediates the type IV hypersens rxn?
CD8 cells
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Corticomedullary junction
S. aureus and S. pyogenes

40. Transplant rejection: preformed host antibody mediated
Hyperacute : occlusion - ischemia - necrosis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
2
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

41. Which MHC complex to CD8 cells bind
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
MHC I
Regulates the humoral response
Ceilac disase

42. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
SLE - nonspecific
IgA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
CD21

43. Which cytokine induces Th1 cell profile in CD4 cells
Autoimmune hepatitis
Signal 1 = APC - signal 2 = B7 and CD28
CD8 cells
IL-12

44. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
IL-12
Everything else - not right arm and right half of head
Hereditary angioedema

45. Which portion of the antibody determines the isotype
Other vasculitidies
Fc
III
Howell - Jolly bodies - Target cells - thrombocytosis

46. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Signal 1 = APC - signal 2 = B7 and CD28
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

47. What do you find in the medulla of the thymus?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Pemphigus vulgaris

48. How are NK cells stimulated?
IgA
IL-12 - IFN- beta. IFN- alpha
Pernicious anemia (to B12 def) - hashimotos thyroiditis
II

49. Which B T cell interaction allows for immunologic memory and class switching?
Ceilac disase
IgG
Il -4
CD40 and CD40L

50. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
MHC II 4 x 2=8
Sjorgen's syndrome
Neisseria bacteremia