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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which antibodies activate the classic pathway
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgG - IgM GM makes classic cars
APCs - and DR - DP and DQ
All nucleated cells (no RBCs) A - B - C

2. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
IgG
RA
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

3. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
RA
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
SCID
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

4. antismooth muscle
IgE
CD40 and CD40L
Autoimmune hepatitis
III

5. Which complement proteins make up the MAC
C5b -9
Bruton's agamma
Chronic mucocutaneaous candidiasis
Upper limb and breast

6. What inhibits Th2 cells
Neisseria bacteremia
Fc and Fab
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IFN gamma

7. Which MHC complex to CD4 cells bind
Hashimotos
Mesenchyme
Right arm and right half of head
MHC II 4 x 2=8

8. Which infections require administering passive immunity?
Ceilac disase
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Drug induced lupus

9. Which is the receptors for EBV?
Hyper IgE syndrome (Job's)
CD21
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Fc and Fab

10. anti U1 RNP
Drug induced lupus
Mixed connective tissue disease
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Chediak Higashi

11. HLA- DR3
C5b -9
DM type 1
Goodpastures
Wegeners granulomatosis

12. Which antibody (IgM or IgG) crosses the placenta?
SLE
IgG
SLE - nonspecific
Signal 1 = APC - signal 2 = B7 and CD28

13. which follicles (primary or secondary) have active germinal centers?
Innate
Secondary
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Stomach

14. Which cell mediates the type IV hypersens rxn?
Stomach
Sjorgen's syndrome
Chronic: fibrosis of graft tissue and blood vessels
CD8 cells

15. anti SS A/B or anti Ro/La

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16. HLA- B27

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17. antimicrosomal - antithyroglobulin
Graves' dz
Hashimotos
IL-4 - 5 - 10
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

18. anti basement membrane
DM type 1
Goodpastures
RA
IgM and IgD

19. HLA- B8

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20. Anticentromere
Chronic granulomatous disease
DM type 1
MHC II 4 x 2=8
Scleroderma CREST

21. HLA- A3
Hemochromocytosis
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
DM type 1
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

22. Which parasites exhibit antigenic variation
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Chronic: fibrosis of graft tissue and blood vessels
Trypanosomes - programmed rearrangement
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

23. Which immunoglobulin is a pentamer
Fab
Goodpastures
Chronic granulomatous disease
IgM

24. HLA- DR7
Steroid - responsive nephrotic syndrome
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Innate
CD8 cells

25. X- linked recessive defect with progessive deletion of B and T cells
III
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
MS - hay fever - SLE - goodpasture's
Perforin - granzyme - granulysin

26. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
2
SLE - nonspecific
DM type 1
Chronic granulomatous disease

27. What kind of bacteria do macrophages remove from the spleen?
IgM
Corticomedullary junction
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Perforin - granzyme - granulysin

28. ANA
Pemphigus vulgaris
CD14
Ataxia telangectasia
SLE - nonspecific

29. How many signals are required for T cell activation or B cell class switching?
2
CD14
Primary biliary cirrohosis
All nucleated cells (no RBCs) A - B - C

30. What interferes with viruses?
IgA
Prevents attachment of bacteria and viruses to mucous membranes
Goodpastures
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

31. Antimitochondrial
Chronic mucocutaneaous candidiasis
Primary biliary cirrohosis
CD21
Mature t cells - epithelial reticular cells - Hassalls corpuscles

32. Defectin in isotype switching
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Selective Ig def - IgA most common
2

33. Which type of hypersens rxn is the arthus rxn
Hyperacute : occlusion - ischemia - necrosis
CD56
Chediak Higashi
III

34. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Stomach
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
DM type 1

35. What are the classic example of bacterial antigen variation and the unique mechanims
Hemochromocytosis
C3b
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Leukocyte adhesion deficiency type 1

36. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Corticomedullary junction
I
IL-12

37. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Hyper IgE syndrome (Job's)
No - peptides only can can be presented on MHC molecules
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Chronic: fibrosis of graft tissue and blood vessels

38. p - ANCA
Bruton's agamma
Other vasculitidies
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IL-12 - IFN- beta. IFN- alpha

39. HLA- D2

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40. What are the cytokines involved in macrophage/lymphocyte interaction
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Trypanosomes - programmed rearrangement
Major shift minor drift
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

41. Anti - IgG (RF)
CD21
APCs - and DR - DP and DQ
IL-12
RA

42. Which is the most abundant immunoglobulin in the blood?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Right arm and right half of head
RA
IgG

43. transplant rejection: T cell and antibody mediated vasular damage
Scleroderma CREST
Chronic: fibrosis of graft tissue and blood vessels
Wegeners granulomatosis
MHC II 4 x 2=8

44. HLA- DR5
Hereditary angioedema
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Pemphigus vulgaris

45. Which cytokine induces Th1 cell profile in CD4 cells
PMNs recruited by IL-8 to clear infxns
Stomach
IgM
IL-12

46. What does the thoracic duct drain?
Secondary
CD8 cells
Everything else - not right arm and right half of head
Prevents attachment of bacteria and viruses to mucous membranes

47. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Hereditary angioedema
Wegeners granulomatosis
Ceilac disase

48. What do superantigens do?
Selective Ig def - IgA most common
IL-4 - 5 - 10
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
RA

49. What does the Th2 response do?
Regulates the humoral response
Chronic granulomatous disease
MHC II 4 x 2=8
Signal 1 = APC - signal 2 = B7 and CD28

50. How do CD8 cells kill?
CD40 and CD40L
Scleroderma CREST
Perforin - granzyme - granulysin
Mixed connective tissue disease