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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. anti glutamate decarboxylase
Fab
Pernicious anemia (to B12 def) - hashimotos thyroiditis
DM type 1
C3b

2. AR - defect in microtubule fxn with decreased phagocytosis
Ataxia telangectasia
Signal 1 = APC - signal 2 = B7 and CD28
Chediak Higashi
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

3. What are the two signals in helper T activation?
III
Signal 1 = APC - signal 2 = B7 and CD28
Fab
IgG

4. Which areas of the body are drained by the axillary lymph node
Everything else - not right arm and right half of head
Fc
Upper limb and breast
No - peptides only can can be presented on MHC molecules

5. Antimitochondrial
Howell - Jolly bodies - Target cells - thrombocytosis
Primary biliary cirrohosis
Chediak Higashi
Bruton's agamma

6. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
Perforin - granzyme - granulysin
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Everything else - not right arm and right half of head

7. antismooth muscle
Autoimmune hepatitis
Macs - dendritic cell - B cell
MHC I
Sjorgen's syndrome

8. p - ANCA
Other vasculitidies
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
2
SLE - nonspecific

9. What are the cell surface receptors on MACS
Trypanosomes - programmed rearrangement
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Steroid - responsive nephrotic syndrome
IgA

10. What are the 3 funxtions of antibodies?
Opsonization - neutralization and complement activation
C3b
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Superficial inguinal pectinate line

11. What do you find in the medulla of the thymus?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Opsonization - neutralization and complement activation
Mature t cells - epithelial reticular cells - Hassalls corpuscles

12. Where do positive and negative selection occur in the thymus?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Corticomedullary junction
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Autoimmune hepatitis

13. Which bacteria secrete superantigen
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
S. aureus and S. pyogenes
APCs - and DR - DP and DQ
IgM

14. which areas of the body are drained by the celiac lymph node?
III
CD8 cells
RA
Stomach

15. Which cell mediates the type IV hypersens rxn?
CD8 cells
MHC II 4 x 2=8
Mixed connective tissue disease
IL-4 - 5 - 10

16. What embryologic tissue are lymphcytes derived from
Stomach
Mesenchyme
Scleroderma diffuse
Opsonization - neutralization and complement activation

17. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
IL-2 and IFN gamma
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Selective Ig def - IgA most common

18. What are the two signals in cytotoxic T cells activation?
SLE
Il -4
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

19. Which type of hypersens rxn is delayed
Mesenchyme
Primary biliary cirrohosis
IV
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

20. What are the three things you find post splenectomy
III
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Howell - Jolly bodies - Target cells - thrombocytosis
Adaptive

21. HLA- B8

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22. Which kind of immunity is germline encoded?
DiGeorge
Innate
Chronic mucocutaneaous candidiasis
I

23. Anti ds DNA - anti Smith
IL-12 - IFN- beta. IFN- alpha
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
SLE
SCID

24. Which type of hypersens rxn is the arthus rxn
IgG - IgM GM makes classic cars
III
IgM
MHC II 4 x 2=8

25. What do mature B lymphos express on their surface?
DiGeorge
Regulates the humoral response
IgM and IgD
Chronic mucocutaneaous candidiasis

26. Which B T cell interaction allows for immunologic memory and class switching?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
CD40 and CD40L
Ataxia telangectasia
Stomach

27. Which antibody mediates a type Hypersens rxn?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Hyper IgE syndrome (Job's)
IgE

28. Cell surface receptors on T cells
Howell - Jolly bodies - Target cells - thrombocytosis
CD8 cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
C5b -9

29. which follicles (primary or secondary) have active germinal centers?
Secondary
Signal 1 = APC - signal 2 = B7 and CD28
B cell localization and proliferation
MHC II 4 x 2=8

30. Which MHC complex to CD4 cells bind
MHC II 4 x 2=8
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Macs - dendritic cell - B cell
Leukocyte adhesion deficiency type 1

31. How are NK cells stimulated?
Superficial inguinal pectinate line
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Regulates the humoral response
IL-12 - IFN- beta. IFN- alpha

32. anti basement membrane
Mesenchyme
Poly/dermato myositis
Goodpastures
MHC I

33. What is the unique cell marker for NK cells
All nucleated cells (no RBCs) A - B - C
RA - DM type 1
CD56
IV

34. antigliadin - antiendomysial
Ceilac disase
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Pernicious anemia (to B12 def) - hashimotos thyroiditis
CD8 cells

35. Which cytokine induces Th1 cell profile in CD4 cells
Primary biliary cirrohosis
Hemochromocytosis
IL-12
Ceilac disase

36. What are the three APCs
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Macs - dendritic cell - B cell
Autoimmune hepatitis

37. Defect in CD40L on helper T
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Hyper IgM

38. anti - Jo 1
Poly/dermato myositis
SLE - nonspecific
Hemochromocytosis
Chronic: fibrosis of graft tissue and blood vessels

39. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
SCID
Macs - dendritic cell - B cell
IL-12
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

40. Deficiency in DAF
No - peptides only can can be presented on MHC molecules
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
B cell localization and proliferation
Goodpastures

41. Which type of hypersens rxn is immune complex mediate
Chronic: fibrosis of graft tissue and blood vessels
III
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Stomach

42. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
MS - hay fever - SLE - goodpasture's
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Primary biliary cirrohosis
IgM and IgD

43. How do NK cells kill?
Wegeners granulomatosis
Other vasculitidies
CD8 cells
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

44. HLA- DR3
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
DM type 1
IgM and IgD
SCID

45. T cell dysfunction
Mesenchyme
IgG - IgM GM makes classic cars
Ceilac disase
Chronic mucocutaneaous candidiasis

46. Which antibody mediates type II and type III hypersens rxn
III
IgG
Paracortex
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

47. Which receptor on MACS to endotoxin directy stimulate?
IgG
Major shift minor drift
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
CD14

48. Which immunoglobulin is a pentamer
Chronic: fibrosis of graft tissue and blood vessels
PMNs recruited by IL-8 to clear infxns
Autoimmune hepatitis
IgM

49. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
IL-12 def
IgG
Signal 1 = APC - signal 2 = B7 and CD28

50. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
Adaptive
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
DM type 1