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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Secondary
Primary biliary cirrohosis
Chronic: fibrosis of graft tissue and blood vessels

2. Which MHC complex to CD8 cells bind
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Howell - Jolly bodies - Target cells - thrombocytosis
MHC I
DM type 1

3. Which kind of immunity is germline encoded?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
III
Innate
S. aureus and S. pyogenes

4. Which parts of the antibody to heavy chain contribute?
Leukocyte adhesion deficiency type 1
APCs - and DR - DP and DQ
Fc
Fc and Fab

5. Defect in CD40L on helper T
Hyper IgM
SLE
2
All nucleated cells (no RBCs) A - B - C

6. Defect in LFA-1 integrin CD18 protein on phagocytes
IL-12
Prevents attachment of bacteria and viruses to mucous membranes
IL-12 def
Leukocyte adhesion deficiency type 1

7. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
I

8. Which is the most abundant immunoglobulin in the blood?
CD21
Upper limb and breast
IgG
Mesenchyme

9. Which immunoglobulin is a pentamer
IgM
MHC II 4 x 2=8
Poly/dermato myositis
B cell localization and proliferation

10. What does HOT- T- Bone stEAk stand for?
IgG - IgM GM makes classic cars
IgM and IgD
SLE - nonspecific
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

11. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
CD14
Superficial inguinal pectinate line
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

12. Which complement proteins make up the MAC
IgM
C5b -9
Help B cells make antibody - secrete IFN gamma to activate macs
2

13. Which type of hypersens rxn is serum sickness?
CD21
IL-12
III
All nucleated cells (no RBCs) A - B - C

14. Cell surface receptors on T cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
S. aureus and S. pyogenes
Fab
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

15. Which receptor on MACS to endotoxin directy stimulate?
Chronic mucocutaneaous candidiasis
Stomach
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
CD14

16. How are NK cells stimulated?
Howell - Jolly bodies - Target cells - thrombocytosis
Paracortex
IL-12 - IFN- beta. IFN- alpha
IL-12

17. What are the two signals in helper T activation?
Chronic: fibrosis of graft tissue and blood vessels
DM type 1
SLE
Signal 1 = APC - signal 2 = B7 and CD28

18. What are the 4 T's of type IV hypersense
IgG
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgM

19. anti basement membrane
MHC II 4 x 2=8
Fc and Fab
IL-4 - 5 - 10
Goodpastures

20. Antimitochondrial
Primary biliary cirrohosis
Autoimmune hepatitis
Corticomedullary junction
Chronic granulomatous disease

21. What does a deficiency in C1 esterase inhibitor lead to?
IgM and IgD
III
III
Hereditary angioedema

22. Which antibody mediates a type Hypersens rxn?
APCs - and DR - DP and DQ
Prevents attachment of bacteria and viruses to mucous membranes
IgE
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

23. Which type of hypersens rxn is delayed
Scleroderma diffuse
IV
Chronic granulomatous disease
Common variable immunodeficiency (CVID)

24. HLA- B27

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25. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
Prevents attachment of bacteria and viruses to mucous membranes
APCs - and DR - DP and DQ
Secondary

26. Which area of the lymph node englarges in an extreme immune response
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Paracortex
I
Mixed connective tissue disease

27. Where is MHC I expressed - and which HLA molecules code for it
Primary biliary cirrohosis
2
All nucleated cells (no RBCs) A - B - C
Hemochromocytosis

28. What cytokines to Th2 cells secrete?
Selective Ig def - IgA most common
CD40 and CD40L
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-4 - 5 - 10

29. anti glutamate decarboxylase
DM type 1
IgG
IL-4 - 5 - 10
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

30. X- linked recessive defect with progessive deletion of B and T cells
CD8 cells
Hyperacute : occlusion - ischemia - necrosis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Macs - dendritic cell - B cell

31. Which MHC complex to CD4 cells bind
MHC II 4 x 2=8
Chronic granulomatous disease
Regulates the humoral response
Drug induced lupus

32. Which cell mediates the type IV hypersens rxn?
Chediak Higashi
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
MS - hay fever - SLE - goodpasture's
CD8 cells

33. Which parts of the antibody to light chain contribute
Fab
RA - DM type 1
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IgG

34. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
MS - hay fever - SLE - goodpasture's
Autoimmune hepatitis
IL-2 and IFN gamma

35. Which portion of the antibody determines the isotype
CD14
Fc
Sjorgen's syndrome
Selective Ig def - IgA most common

36. HLA- DR4
Pernicious anemia (to B12 def) - hashimotos thyroiditis
RA - DM type 1
III
CD8 cells

37. What is the main function of IgA
APCs - and DR - DP and DQ
Prevents attachment of bacteria and viruses to mucous membranes
Fc
Mixed connective tissue disease

38. What embryologic tissue are lymphcytes derived from
III
Macs - dendritic cell - B cell
Chediak Higashi
Mesenchyme

39. Which cytokine inhibits Th1 cells
Drug induced lupus
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-10
Pemphigus vulgaris

40. Anticentromere
Help B cells make antibody - secrete IFN gamma to activate macs
Upper limb and breast
Other vasculitidies
Scleroderma CREST

41. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Stomach
Sjorgen's syndrome
Primary biliary cirrohosis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

42. Which type of hypersens rxn is antibody mediated?
II
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Howell - Jolly bodies - Target cells - thrombocytosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

43. What are the two signals in cytotoxic T cells activation?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgG

44. Th cells don't produce IFN gamma - no PMN response

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45. What are the two signals required for B cells class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
B cell localization and proliferation
III
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

46. Which cytokine induces Th2 cell profile in CD4 cells
Goodpastures
Il -4
Mixed connective tissue disease
Chediak Higashi

47. anti - Jo 1
Poly/dermato myositis
Major shift minor drift
Signal 1 = APC - signal 2 = B7 and CD28
Paracortex

48. Which complement protein opsonizes bacteria?
Hemochromocytosis
Other vasculitidies
C3b
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

49. What are the classic example of bacterial antigen variation and the unique mechanims
CD56
Pemphigus vulgaris
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Hyper IgE syndrome (Job's)

50. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
DM type 1
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IgM