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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What embryologic tissue are lymphcytes derived from
Hyper IgM
IL-12 - IFN- beta. IFN- alpha
Mesenchyme
SLE - nonspecific

2. What do you find in the medulla of the thymus?
Prevents attachment of bacteria and viruses to mucous membranes
Hemochromocytosis
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Innate

3. HLA- DR4
SLE
Chronic: fibrosis of graft tissue and blood vessels
RA - DM type 1
Scleroderma CREST

4. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Common variable immunodeficiency (CVID)
IgM and IgD
Hyper IgE syndrome (Job's)

5. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgG - IgM GM makes classic cars
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

6. Which type of hypersens rxn is immune complex mediate
SLE
Steroid - responsive nephrotic syndrome
IgM and IgD
III

7. Where do positive and negative selection occur in the thymus?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Pemphigus vulgaris
Corticomedullary junction
Other vasculitidies

8. What is the clinical picture for serum sickness?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Major shift minor drift
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Mature t cells - epithelial reticular cells - Hassalls corpuscles

9. What do superantigens do?
Hemochromocytosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Neisseria bacteremia
Pernicious anemia (to B12 def) - hashimotos thyroiditis

10. Anticentromere
I
Scleroderma CREST
Drug induced lupus
Adaptive

11. decreased Th1 response
IgA
IL-12 def
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Superficial inguinal pectinate line

12. HLA- DR5
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IL-4 - 5 - 10
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Neisseria bacteremia

13. Defect in DNA repair enzymes
Hyper IgM
IFN gamma
Ataxia telangectasia
I

14. Cell surface receptors on B cels
CD14
MHC I
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Opsonization - neutralization and complement activation

15. Which is the receptors for EBV?
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
CD21
IL-10

16. Which kind of immunity is germline encoded?
Mesenchyme
DM type 1
Innate
Hyper IgM

17. What inhibits Th2 cells
Perforin - granzyme - granulysin
IL-12 - IFN- beta. IFN- alpha
IFN gamma
IL-10

18. Cell surface receptors on T cells
I
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
CD14

19. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Help B cells make antibody - secrete IFN gamma to activate macs
Bruton's agamma
DM type 1

20. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Prevents attachment of bacteria and viruses to mucous membranes
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgA

21. Deficiency in DAF
IL-12 def
APCs - and DR - DP and DQ
Wegeners granulomatosis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

22. What kind of bacteria do macrophages remove from the spleen?
Common variable immunodeficiency (CVID)
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
III
Drug induced lupus

23. Antihistone
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Drug induced lupus
Hereditary angioedema
Macs - dendritic cell - B cell

24. What is the role of CD4 cels
Graves' dz
Help B cells make antibody - secrete IFN gamma to activate macs
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IgG

25. Which areas of the body are drained by the axillary lymph node
IgG
Innate
Upper limb and breast
Drug induced lupus

26. HLA- B8

27. transplant rejection: T cell and antibody mediated vasular damage
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Chronic: fibrosis of graft tissue and blood vessels
CD56
CD40 and CD40L

28. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Right arm and right half of head
IV
I

29. Which type of hypersens rxn is antibody mediated?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
APCs - and DR - DP and DQ
II
I

30. Which cell mediates the type IV hypersens rxn?
CD8 cells
Innate
Chediak Higashi
Bruton's agamma

31. anti glutamate decarboxylase
Mesenchyme
IgA
DM type 1
Upper limb and breast

32. What do mature B lymphos express on their surface?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Chronic mucocutaneaous candidiasis
IgM and IgD
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

33. Which cytokine induces Th1 cell profile in CD4 cells
Hyperacute : occlusion - ischemia - necrosis
IL-12
I
Mixed connective tissue disease

34. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
Chronic: fibrosis of graft tissue and blood vessels
Hereditary angioedema
Everything else - not right arm and right half of head

35. What are the 3 funxtions of antibodies?
Adaptive
Sjorgen's syndrome
CD21
Opsonization - neutralization and complement activation

36. What are the cell surface receptors on MACS
Signal 1 = APC - signal 2 = B7 and CD28
Right arm and right half of head
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Sjorgen's syndrome

37. antidesmoglein
III
Help B cells make antibody - secrete IFN gamma to activate macs
Pemphigus vulgaris
IgG

38. How do CD8 cells kill?
Hashimotos
IFN gamma
Wegeners granulomatosis
Perforin - granzyme - granulysin

39. HLA- DR7
Steroid - responsive nephrotic syndrome
Paracortex
Trypanosomes - programmed rearrangement
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

40. AR - defect in microtubule fxn with decreased phagocytosis
IgG
Selective Ig def - IgA most common
Chediak Higashi
II

41. Where is MHC II expressed and and which HLA molecules codes for it
Scleroderma CREST
Paracortex
APCs - and DR - DP and DQ
Hyper IgE syndrome (Job's)

42. What is the difference in antigenic variation in viruses
Major shift minor drift
IL-12 def
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

43. Which MHC complex to CD4 cells bind
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Macs - dendritic cell - B cell
Secondary
MHC II 4 x 2=8

44. What happens in the follicle of the lymph node
Chronic mucocutaneaous candidiasis
Chronic granulomatous disease
S. aureus and S. pyogenes
B cell localization and proliferation

45. anti SS A/B or anti Ro/La

46. What kind of hypersens rxn in anaphylaxis
B cell localization and proliferation
I
Paracortex
C5b -9

47. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Superficial inguinal pectinate line
Opsonization - neutralization and complement activation
C5b -9

48. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Adaptive
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

49. Which parts of the antibody to heavy chain contribute?
IgA
Major shift minor drift
Fc and Fab
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

50. HLA- DR3
Drug induced lupus
APCs - and DR - DP and DQ
DM type 1
Help B cells make antibody - secrete IFN gamma to activate macs