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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which cytokine induces Th2 cell profile in CD4 cells
RA
2
Il -4
B cell localization and proliferation

2. Which parasites exhibit antigenic variation
Everything else - not right arm and right half of head
IL-12 - IFN- beta. IFN- alpha
Trypanosomes - programmed rearrangement
Hyper IgE syndrome (Job's)

3. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
All nucleated cells (no RBCs) A - B - C
No - peptides only can can be presented on MHC molecules
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

4. HLA- DR5
DiGeorge
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Mesenchyme
Chronic mucocutaneaous candidiasis

5. anti basement membrane
Goodpastures
Corticomedullary junction
III
Wegeners granulomatosis

6. What inhibits Th2 cells
Drug induced lupus
Autoimmune hepatitis
Common variable immunodeficiency (CVID)
IFN gamma

7. antidesmoglein
Trypanosomes - programmed rearrangement
Mesenchyme
Pemphigus vulgaris
Everything else - not right arm and right half of head

8. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-12 - IFN- beta. IFN- alpha
SLE
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

9. Which parts of the antibody to light chain contribute
Fab
IL-12 - IFN- beta. IFN- alpha
C5b -9
Ataxia telangectasia

10. Anti ds DNA - anti Smith
SLE
IL-4 - 5 - 10
B cell localization and proliferation
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

11. Which is the receptors for EBV?
C5b -9
II
CD21
Upper limb and breast

12. HLA- B8

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13. Which areas of the body are drained by the axillary lymph node
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Upper limb and breast
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgE

14. Defect in LFA-1 integrin CD18 protein on phagocytes
Other vasculitidies
III
PMNs recruited by IL-8 to clear infxns
Leukocyte adhesion deficiency type 1

15. HLA- DR3
IL-2 and IFN gamma
DM type 1
2
Bruton's agamma

16. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
Hereditary angioedema
Selective Ig def - IgA most common
III

17. Which cytokine inhibits Th1 cells
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgE
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IL-10

18. antimicrosomal - antithyroglobulin
Hashimotos
Other vasculitidies
IgA
Steroid - responsive nephrotic syndrome

19. What are the two signals in helper T activation?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD8 cells
Hyper IgM
Signal 1 = APC - signal 2 = B7 and CD28

20. Which area of the lymph node englarges in an extreme immune response
Paracortex
III
IgG - IgM GM makes classic cars
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

21. Antimitochondrial
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Chronic granulomatous disease
Scleroderma diffuse
Primary biliary cirrohosis

22. Anti - IgG (RF)
IgM and IgD
Major shift minor drift
RA
CD21

23. What does the Th2 response do?
Regulates the humoral response
SLE - nonspecific
Goodpastures
Perforin - granzyme - granulysin

24. What does a deficiency in C3 lead to...
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
CD21
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

25. What does a deficiency in C5- C8 lead to?
Innate
Neisseria bacteremia
CD14
Goodpastures

26. Cell surface receptors on T cells
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
DiGeorge
I

27. Which type of hypersens rxn is the arthus rxn
III
Ceilac disase
PMNs recruited by IL-8 to clear infxns
IL-12 def

28. anti SS A/B or anti Ro/La

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29. Which antibody mediates a type Hypersens rxn?
Opsonization - neutralization and complement activation
Drug induced lupus
SLE - nonspecific
IgE

30. which kind of immunity is characterized by receptors that undergo VDJ recombination?
IL-4 - 5 - 10
Adaptive
Leukocyte adhesion deficiency type 1
Major shift minor drift

31. Which immunoglobulin is a pentamer
Selective Ig def - IgA most common
IgM
CD56
Regulates the humoral response

32. What interferes with viruses?
Paracortex
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
DM type 1

33. Which type of hypersens rxn is delayed
C5b -9
IL-4 - 5 - 10
IV
Hyper IgE syndrome (Job's)

34. What does a deficiency in C1 esterase inhibitor lead to?
IL-12
Superficial inguinal pectinate line
Hereditary angioedema
Prevents attachment of bacteria and viruses to mucous membranes

35. Th cells don't produce IFN gamma - no PMN response

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36. antismooth muscle
APCs - and DR - DP and DQ
Chediak Higashi
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Autoimmune hepatitis

37. Which B T cell interaction allows for immunologic memory and class switching?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Neisseria bacteremia
CD40 and CD40L
IgE

38. which follicles (primary or secondary) have active germinal centers?
Chediak Higashi
Upper limb and breast
Trypanosomes - programmed rearrangement
Secondary

39. What is the clinical picture for serum sickness?
PMNs recruited by IL-8 to clear infxns
Paracortex
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
APCs - and DR - DP and DQ

40. Which parts of the antibody to heavy chain contribute?
Ceilac disase
Opsonization - neutralization and complement activation
Primary biliary cirrohosis
Fc and Fab

41. Which receptor on MACS to endotoxin directy stimulate?
Chronic mucocutaneaous candidiasis
Steroid - responsive nephrotic syndrome
Scleroderma CREST
CD14

42. Which MHC complex to CD8 cells bind
Chronic granulomatous disease
IgM and IgD
Hyperacute : occlusion - ischemia - necrosis
MHC I

43. Where do positive and negative selection occur in the thymus?
Corticomedullary junction
IL-2 and IFN gamma
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
CD40 and CD40L

44. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
RA
Innate

45. Cell surface receptors on B cels
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

46. Which portion of the antibody determines the isotype
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hyperacute : occlusion - ischemia - necrosis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Fc

47. What do you find in the medulla of the thymus?
IgG
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Help B cells make antibody - secrete IFN gamma to activate macs
Opsonization - neutralization and complement activation

48. X- linked recessive defect with progessive deletion of B and T cells
RA - DM type 1
Scleroderma diffuse
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
CD8 cells

49. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
II
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
SLE

50. What does clean up on Aisle 8 stand for?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
C5b -9
PMNs recruited by IL-8 to clear infxns
Upper limb and breast