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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which infections require administering passive immunity?
MS - hay fever - SLE - goodpasture's
Stomach
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Wegeners granulomatosis

2. antidesmoglein
Fc and Fab
Fc
Fab
Pemphigus vulgaris

3. HLA- A3
Hemochromocytosis
Graves' dz
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Major shift minor drift

4. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
Common variable immunodeficiency (CVID)
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Bruton's agamma

5. What does HOT- T- Bone stEAk stand for?
IL-12 def
Pemphigus vulgaris
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

6. What are the 3 funxtions of antibodies?
Fc
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Opsonization - neutralization and complement activation
RA - DM type 1

7. anti U1 RNP
III
Mixed connective tissue disease
IL-12 - IFN- beta. IFN- alpha
Ataxia telangectasia

8. HLA- DR5
Major shift minor drift
Pemphigus vulgaris
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

9. HLA- B8

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10. What is the clinical picture for serum sickness?
IgG - IgM GM makes classic cars
Chronic mucocutaneaous candidiasis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
II

11. What are the two signals in cytotoxic T cells activation?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Right arm and right half of head

12. What is the arthus rxn?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgM
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

13. Th cells don't produce IFN gamma - no PMN response

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14. Which cell mediates the type IV hypersens rxn?
CD8 cells
Chediak Higashi
IgA
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

15. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Hereditary angioedema
III

16. thwat does the Right lymphatic duct drain?
Right arm and right half of head
C5b -9
Major shift minor drift
Trypanosomes - programmed rearrangement

17. Which type of hypersens rxn is the arthus rxn
III
MHC I
Steroid - responsive nephrotic syndrome
Il -4

18. p - ANCA
Upper limb and breast
Other vasculitidies
CD8 cells
Primary biliary cirrohosis

19. What are the two signals required for B cells class switching?
CD14
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Poly/dermato myositis
Hyper IgE syndrome (Job's)

20. anti basement membrane
IgG
Goodpastures
PMNs recruited by IL-8 to clear infxns
Macs - dendritic cell - B cell

21. Which areas of the body are drained by the axillary lymph node
Other vasculitidies
Upper limb and breast
Regulates the humoral response
IgG

22. What do mature B lymphos express on their surface?
IgM and IgD
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
DM type 1
SCID

23. Which type of hypersens rxn is antibody mediated?
II
Signal 1 = APC - signal 2 = B7 and CD28
IgG - IgM GM makes classic cars
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

24. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
Fc and Fab
Ceilac disase
Bruton's agamma

25. which follicles (primary or secondary) have active germinal centers?
Secondary
IgE
Hyper IgE syndrome (Job's)
Leukocyte adhesion deficiency type 1

26. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Scleroderma CREST
Chronic granulomatous disease

27. Which type of hypersens rxn is serum sickness?
IgM
III
Pernicious anemia (to B12 def) - hashimotos thyroiditis
B cell localization and proliferation

28. What is the role of CD4 cels
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Trypanosomes - programmed rearrangement
Help B cells make antibody - secrete IFN gamma to activate macs
Chronic: fibrosis of graft tissue and blood vessels

29. Cell surface receptors on B cels
IgM
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
II

30. What is the unique cell marker for NK cells
Opsonization - neutralization and complement activation
Ataxia telangectasia
CD56
III

31. Which B T cell interaction allows for immunologic memory and class switching?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
CD56
Hyperacute : occlusion - ischemia - necrosis
CD40 and CD40L

32. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Hemochromocytosis
Chronic: fibrosis of graft tissue and blood vessels
Leukocyte adhesion deficiency type 1

33. What are the 4 T's of type IV hypersense
IFN gamma
Hereditary angioedema
IL-2 and IFN gamma
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

34. HLA- DR4
IFN gamma
Pernicious anemia (to B12 def) - hashimotos thyroiditis
RA - DM type 1
III

35. Deficiency in DAF
Wegeners granulomatosis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

36. Which receptor on MACS to endotoxin directy stimulate?
Neisseria bacteremia
Fc
CD14
II

37. Which area of the lymph node englarges in an extreme immune response
Ceilac disase
Paracortex
DiGeorge
Fab

38. What do superantigens do?
CD21
Signal 1 = APC - signal 2 = B7 and CD28
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
S. aureus and S. pyogenes

39. Which MHC complex to CD8 cells bind
MHC I
S. aureus and S. pyogenes
CD14
Scleroderma diffuse

40. Anti Scl 70 (DNA topo I
S. aureus and S. pyogenes
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Scleroderma diffuse
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

41. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
No - peptides only can can be presented on MHC molecules
PMNs recruited by IL-8 to clear infxns
Macs - dendritic cell - B cell

42. anti - Jo 1
No - peptides only can can be presented on MHC molecules
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Poly/dermato myositis

43. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Hereditary angioedema
Adaptive
Hyperacute : occlusion - ischemia - necrosis
IL-10

44. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Secondary
DiGeorge
B cell localization and proliferation
Fc and Fab

45. HLA- DR3
Selective Ig def - IgA most common
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
DM type 1

46. c - ANCA
Wegeners granulomatosis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Poly/dermato myositis
Signal 1 = APC - signal 2 = B7 and CD28

47. What does a deficiency in C5- C8 lead to?
CD14
Neisseria bacteremia
DiGeorge
Fab

48. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
MHC I
RA - DM type 1
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

49. What kind of hypersens rxn in anaphylaxis
I
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Hyper IgM

50. Defect in LFA-1 integrin CD18 protein on phagocytes
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Leukocyte adhesion deficiency type 1
Scleroderma CREST
Prevents attachment of bacteria and viruses to mucous membranes