Test your basic knowledge |

Immunology

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which area of the lymph node englarges in an extreme immune response
SLE
Chronic granulomatous disease
Paracortex
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

2. antidesmoglein
C5b -9
Upper limb and breast
Pemphigus vulgaris
Signal 1 = APC - signal 2 = B7 and CD28

3. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Adaptive
Goodpastures

4. Which cytokine inhibits Th1 cells
Fc and Fab
Neisseria bacteremia
CD8 cells
IL-10

5. anti glutamate decarboxylase
I
Common variable immunodeficiency (CVID)
DM type 1
Graves' dz

6. anti - Jo 1
MHC II 4 x 2=8
Hemochromocytosis
Secondary
Poly/dermato myositis

7. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
CD56
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Help B cells make antibody - secrete IFN gamma to activate macs

8. How many signals are required for T cell activation or B cell class switching?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Major shift minor drift
Ataxia telangectasia
2

9. Defect in CD40L on helper T
Hyper IgM
Upper limb and breast
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
I

10. Which bacteria secrete superantigen
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
S. aureus and S. pyogenes
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

11. c - ANCA
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Il -4
Secondary
Wegeners granulomatosis

12. Which complement proteins make up the MAC
CD56
C5b -9
IL-12
RA

13. Which kind of immunity is germline encoded?
Howell - Jolly bodies - Target cells - thrombocytosis
Innate
Right arm and right half of head
All nucleated cells (no RBCs) A - B - C

14. Cell surface receptors on T cells
Fab
B cell localization and proliferation
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Macs - dendritic cell - B cell

15. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Fc and Fab
Goodpastures
Regulates the humoral response

16. Which cytokine induces Th2 cell profile in CD4 cells
Common variable immunodeficiency (CVID)
IgG
Goodpastures
Il -4

17. Which antibody mediates a type Hypersens rxn?
Hyperacute : occlusion - ischemia - necrosis
Primary biliary cirrohosis
IgE
Il -4

18. Defect in B cell maturation
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Common variable immunodeficiency (CVID)
Macs - dendritic cell - B cell
Scleroderma diffuse

19. T cell dysfunction
Chronic mucocutaneaous candidiasis
Bruton's agamma
Hemochromocytosis
IL-2 and IFN gamma

20. HLA- B8

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

21. thwat does the Right lymphatic duct drain?
Right arm and right half of head
IgG
Other vasculitidies
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

22. Which complement protein opsonizes bacteria?
Hyper IgE syndrome (Job's)
Leukocyte adhesion deficiency type 1
C3b
Neisseria bacteremia

23. Anticentromere
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-12
Scleroderma CREST
Stomach

24. Which MHC complex to CD8 cells bind
Fab
Mature t cells - epithelial reticular cells - Hassalls corpuscles
MHC I
2

25. Where is MHC II expressed and and which HLA molecules codes for it
Leukocyte adhesion deficiency type 1
APCs - and DR - DP and DQ
IgG - IgM GM makes classic cars
II

26. Which antibody mediates type II and type III hypersens rxn
APCs - and DR - DP and DQ
III
IgG
Primary biliary cirrohosis

27. What is the clinical picture for serum sickness?
Other vasculitidies
Major shift minor drift
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
RA

28. ANA
IL-12 def
Stomach
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
SLE - nonspecific

29. p - ANCA
DM type 1
B cell localization and proliferation
Other vasculitidies
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

30. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
2
SLE - nonspecific
DiGeorge
Secondary

31. What is the arthus rxn?
Wegeners granulomatosis
Selective Ig def - IgA most common
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-10

32. Which type of hypersens rxn is the arthus rxn
Selective Ig def - IgA most common
III
IV
Common variable immunodeficiency (CVID)

33. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
MHC II 4 x 2=8
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

34. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgG
IgA
IgG
III

35. X- linked recessive defect with progessive deletion of B and T cells
II
APCs - and DR - DP and DQ
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
CD56

36. HLA- D2

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

37. Which antibodies activate the classic pathway
Stomach
C3b
CD8 cells
IgG - IgM GM makes classic cars

38. What is the unique cell marker for NK cells
MS - hay fever - SLE - goodpasture's
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
CD56
RA - DM type 1

39. Deficiency in DAF
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Other vasculitidies
IV
Superficial inguinal pectinate line

40. Anti ds DNA - anti Smith
Graves' dz
APCs - and DR - DP and DQ
SLE
Ceilac disase

41. Th cells don't produce IFN gamma - no PMN response

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

42. Which areas of the body are drained by the axillary lymph node
DM type 1
DM type 1
Scleroderma diffuse
Upper limb and breast

43. Anti - IgG (RF)
RA
Chronic mucocutaneaous candidiasis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

44. What does HOT- T- Bone stEAk stand for?
Chronic mucocutaneaous candidiasis
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
I
2

45. What interferes with viruses?
IgM and IgD
Scleroderma CREST
IL-12
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

46. What embryologic tissue are lymphcytes derived from
All nucleated cells (no RBCs) A - B - C
Wegeners granulomatosis
Mesenchyme
Chronic granulomatous disease

47. Which receptor on MACS to endotoxin directy stimulate?
CD21
Right arm and right half of head
IL-10
CD14

48. HLA- DR4
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
RA - DM type 1
Corticomedullary junction
Hashimotos

49. Transplant rejection: preformed host antibody mediated
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Hyperacute : occlusion - ischemia - necrosis
IL-10
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

50. antimicrosomal - antithyroglobulin
Hashimotos
Right arm and right half of head
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Hereditary angioedema