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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Stomach
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
MHC I
IgG - IgM GM makes classic cars

2. Defect in LFA-1 integrin CD18 protein on phagocytes
Prevents attachment of bacteria and viruses to mucous membranes
IL-12 def
Sjorgen's syndrome
Leukocyte adhesion deficiency type 1

3. What kind of bacteria do macrophages remove from the spleen?
Chronic: fibrosis of graft tissue and blood vessels
Graves' dz
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

4. Which complement proteins make up the MAC
Bruton's agamma
Hemochromocytosis
C5b -9
Chronic granulomatous disease

5. Which complement protein opsonizes bacteria?
Help B cells make antibody - secrete IFN gamma to activate macs
Drug induced lupus
C3b
Adaptive

6. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Chediak Higashi

7. What are the classic example of bacterial antigen variation and the unique mechanims
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
S. aureus and S. pyogenes
Right arm and right half of head

8. HLA- B8

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9. Which parts of the antibody to light chain contribute
IFN gamma
C3b
S. aureus and S. pyogenes
Fab

10. What are the cytokines involved in macrophage/lymphocyte interaction
Goodpastures
DM type 1
Adaptive
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

11. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Scleroderma CREST
IL-12 - IFN- beta. IFN- alpha
III
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

12. What is the difference in antigenic variation in viruses
Major shift minor drift
IgG - IgM GM makes classic cars
Mixed connective tissue disease
2

13. Which cytokine induces Th1 cell profile in CD4 cells
Adaptive
Chronic mucocutaneaous candidiasis
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-12

14. Which MHC complex to CD8 cells bind
MHC I
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Poly/dermato myositis
Adaptive

15. What kind of hypersens rxn in anaphylaxis
III
III
Sjorgen's syndrome
I

16. What are the three things you find post splenectomy
IL-12 def
Hemochromocytosis
PMNs recruited by IL-8 to clear infxns
Howell - Jolly bodies - Target cells - thrombocytosis

17. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Secondary
Hemochromocytosis
Drug induced lupus

18. What are the 4 T's of type IV hypersense
APCs - and DR - DP and DQ
SCID
CD8 cells
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

19. antidesmoglein
MHC I
Pemphigus vulgaris
Scleroderma diffuse
SLE

20. Which cell mediates the type IV hypersens rxn?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
CD8 cells
RA - DM type 1

21. What are the two signals required for B cells class switching?
IgG
Perforin - granzyme - granulysin
Bruton's agamma
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

22. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Major shift minor drift
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-2 and IFN gamma
Chronic granulomatous disease

23. What does the Th2 response do?
Hyper IgM
IL-2 and IFN gamma
Upper limb and breast
Regulates the humoral response

24. Anticentromere
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Scleroderma CREST
Primary biliary cirrohosis
IgG

25. anti SS A/B or anti Ro/La

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26. How do NK cells kill?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Opsonization - neutralization and complement activation
Fc
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

27. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgE
Corticomedullary junction
IgA
Fc

28. decreased Th1 response
Fab
IgG
C3b
IL-12 def

29. Antimitochondrial
MS - hay fever - SLE - goodpasture's
II
Goodpastures
Primary biliary cirrohosis

30. anti basement membrane
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IFN gamma
Goodpastures
Help B cells make antibody - secrete IFN gamma to activate macs

31. What inhibits Th2 cells
Fab
Chronic: fibrosis of graft tissue and blood vessels
IFN gamma
IL-2 and IFN gamma

32. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
Autoimmune hepatitis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Hyperacute : occlusion - ischemia - necrosis

33. Which is the most abundant immunoglobulin in the blood?
Hereditary angioedema
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IgG
Hyper IgM

34. What happens in the follicle of the lymph node
C5b -9
All nucleated cells (no RBCs) A - B - C
Pernicious anemia (to B12 def) - hashimotos thyroiditis
B cell localization and proliferation

35. anti glutamate decarboxylase
Graves' dz
DM type 1
Stomach
Hemochromocytosis

36. HLA- A3
Hemochromocytosis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Chediak Higashi
Scleroderma diffuse

37. Which bacteria secrete superantigen
DiGeorge
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
S. aureus and S. pyogenes
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

38. antismooth muscle
Hereditary angioedema
Ceilac disase
II
Autoimmune hepatitis

39. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Fab
DM type 1
Neisseria bacteremia
Adaptive

40. Which B T cell interaction allows for immunologic memory and class switching?
IgG
No - peptides only can can be presented on MHC molecules
Steroid - responsive nephrotic syndrome
CD40 and CD40L

41. What is the unique cell marker for NK cells
Innate
CD56
Fc
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

42. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
Adaptive
C5b -9
Fc and Fab

43. ANA
SLE - nonspecific
Adaptive
Fab
IL-4 - 5 - 10

44. Anti ds DNA - anti Smith
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
SLE
II
DM type 1

45. Defect in CD40L on helper T
Hyper IgM
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Upper limb and breast
Primary biliary cirrohosis

46. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Adaptive
IgG - IgM GM makes classic cars
I

47. What does clean up on Aisle 8 stand for?
MHC I
Stomach
C5b -9
PMNs recruited by IL-8 to clear infxns

48. Which type of hypersens rxn is antibody mediated?
II
Perforin - granzyme - granulysin
Secondary
Hyper IgM

49. Defect in B cell maturation
Common variable immunodeficiency (CVID)
Upper limb and breast
IL-2 and IFN gamma
Neisseria bacteremia

50. HLA- DR4
RA - DM type 1
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IgG
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome