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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What are the two signals required for B cells class switching?
SLE - nonspecific
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
B cell localization and proliferation
Perforin - granzyme - granulysin

2. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
SLE
III
Howell - Jolly bodies - Target cells - thrombocytosis

3. transplant rejection: T cell and antibody mediated vasular damage
C3b
Chronic: fibrosis of graft tissue and blood vessels
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Other vasculitidies

4. What is the difference in antigenic variation in viruses
Corticomedullary junction
Major shift minor drift
Superficial inguinal pectinate line
IgM and IgD

5. Which immunoglobulin is a pentamer
SLE
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
CD21
IgM

6. c - ANCA
Autoimmune hepatitis
Wegeners granulomatosis
Leukocyte adhesion deficiency type 1
Signal 1 = APC - signal 2 = B7 and CD28

7. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
2
CD8 cells
Chronic granulomatous disease
IgM and IgD

8. Where do positive and negative selection occur in the thymus?
Hereditary angioedema
Corticomedullary junction
CD21
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

9. What is the clinical picture for serum sickness?
Sjorgen's syndrome
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Fab
Hemochromocytosis

10. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgG
All nucleated cells (no RBCs) A - B - C
IgA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

11. What does a deficiency in C5- C8 lead to?
Chronic: fibrosis of graft tissue and blood vessels
Neisseria bacteremia
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hyper IgM

12. Which cell mediates the type IV hypersens rxn?
CD8 cells
IgG - IgM GM makes classic cars
IV
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

13. What inhibits Th2 cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Poly/dermato myositis
RA
IFN gamma

14. What is the main function of IgA
Fab
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Prevents attachment of bacteria and viruses to mucous membranes
Hashimotos

15. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
Sjorgen's syndrome
Stomach
III

16. which areas of the body are drained by the celiac lymph node?
Right arm and right half of head
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Stomach
Il -4

17. antidesmoglein
Pemphigus vulgaris
Chronic mucocutaneaous candidiasis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

18. What interferes with viruses?
Leukocyte adhesion deficiency type 1
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

19. What is the unique cell marker for NK cells
IL-12 def
Fc
Hemochromocytosis
CD56

20. Which antibody (IgM or IgG) crosses the placenta?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgG
CD40 and CD40L
Chronic granulomatous disease

21. ANA
IL-12 def
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
SLE - nonspecific
Graves' dz

22. Defect in CD40L on helper T
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Prevents attachment of bacteria and viruses to mucous membranes
Ceilac disase
Hyper IgM

23. Which type of hypersens rxn is antibody mediated?
II
IL-4 - 5 - 10
Mature t cells - epithelial reticular cells - Hassalls corpuscles
CD56

24. What are the three APCs
DM type 1
Pemphigus vulgaris
Bruton's agamma
Macs - dendritic cell - B cell

25. Defect in B cell maturation
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Common variable immunodeficiency (CVID)
IL-2 and IFN gamma
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

26. Which is the receptors for EBV?
Paracortex
IgE
Mature t cells - epithelial reticular cells - Hassalls corpuscles
CD21

27. What kind of hypersens rxn in anaphylaxis
Hyperacute : occlusion - ischemia - necrosis
IgM
I
Pernicious anemia (to B12 def) - hashimotos thyroiditis

28. Transplant rejection: preformed host antibody mediated
Superficial inguinal pectinate line
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Hyperacute : occlusion - ischemia - necrosis
Signal 1 = APC - signal 2 = B7 and CD28

29. What embryologic tissue are lymphcytes derived from
Mesenchyme
IgE
Macs - dendritic cell - B cell
II

30. What do superantigens do?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
SCID
Pernicious anemia (to B12 def) - hashimotos thyroiditis

31. Which MHC complex to CD8 cells bind
PMNs recruited by IL-8 to clear infxns
III
MHC I
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

32. What do mature B lymphos express on their surface?
IgM and IgD
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MS - hay fever - SLE - goodpasture's
No - peptides only can can be presented on MHC molecules

33. Anticentromere
Corticomedullary junction
Opsonization - neutralization and complement activation
III
Scleroderma CREST

34. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Other vasculitidies
CD56

35. Which antibody mediates a type Hypersens rxn?
Leukocyte adhesion deficiency type 1
IgE
III
Other vasculitidies

36. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
IL-12 def
DiGeorge
IL-10
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

37. HLA- DR3
Stomach
DM type 1
Regulates the humoral response
2

38. Which type of hypersens rxn is immune complex mediate
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
CD21
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
III

39. Which is the most abundant immunoglobulin in the blood?
RA
IgG
All nucleated cells (no RBCs) A - B - C
Ceilac disase

40. p - ANCA
Hemochromocytosis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Other vasculitidies
Ceilac disase

41. What does a deficiency in C1 esterase inhibitor lead to?
Scleroderma CREST
Hereditary angioedema
Trypanosomes - programmed rearrangement
Regulates the humoral response

42. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
MS - hay fever - SLE - goodpasture's
II
Macs - dendritic cell - B cell

43. Which complement proteins make up the MAC
Help B cells make antibody - secrete IFN gamma to activate macs
C5b -9
Common variable immunodeficiency (CVID)
CD40 and CD40L

44. thwat does the Right lymphatic duct drain?
IgG - IgM GM makes classic cars
Secondary
Right arm and right half of head
Ataxia telangectasia

45. How many signals are required for T cell activation or B cell class switching?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Fc and Fab
CD56
2

46. AR - defect in microtubule fxn with decreased phagocytosis
Major shift minor drift
IgM
Chediak Higashi
DM type 1

47. Where is MHC I expressed - and which HLA molecules code for it
CD21
No - peptides only can can be presented on MHC molecules
CD56
All nucleated cells (no RBCs) A - B - C

48. How do NK cells kill?
Ataxia telangectasia
Wegeners granulomatosis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Everything else - not right arm and right half of head

49. HLA- A3
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Fc and Fab
Sjorgen's syndrome
Hemochromocytosis

50. antismooth muscle
PMNs recruited by IL-8 to clear infxns
Fc and Fab
Autoimmune hepatitis
Superficial inguinal pectinate line