Test your basic knowledge |

Immunology

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Signal 1 = APC - signal 2 = B7 and CD28
IgG - IgM GM makes classic cars
Stomach

2. X linked recessive defect in BTK no B cell differentiation

3. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
Help B cells make antibody - secrete IFN gamma to activate macs
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
DM type 1

4. antigliadin - antiendomysial
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Ceilac disase
S. aureus and S. pyogenes
Autoimmune hepatitis

5. What are the two signals required for B cells class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IV
RA - DM type 1
IgG

6. decreased Th1 response
Chronic: fibrosis of graft tissue and blood vessels
IL-12 def
CD14
Major shift minor drift

7. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
SLE
No - peptides only can can be presented on MHC molecules
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Common variable immunodeficiency (CVID)

8. Antimitochondrial
Chronic: fibrosis of graft tissue and blood vessels
Primary biliary cirrohosis
SLE - nonspecific
Other vasculitidies

9. anti glutamate decarboxylase
Scleroderma diffuse
DM type 1
Drug induced lupus
MHC II 4 x 2=8

10. What kind of bacteria do macrophages remove from the spleen?
Innate
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Fab
Paracortex

11. What is the clinical picture for serum sickness?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
III
Regulates the humoral response
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

12. Where is MHC I expressed - and which HLA molecules code for it
III
All nucleated cells (no RBCs) A - B - C
DiGeorge
Common variable immunodeficiency (CVID)

13. Which portion of the antibody determines the isotype
Scleroderma CREST
Other vasculitidies
Fc
Adaptive

14. What is the arthus rxn?
Poly/dermato myositis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-12 - IFN- beta. IFN- alpha

15. Which complement protein opsonizes bacteria?
Drug induced lupus
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Signal 1 = APC - signal 2 = B7 and CD28
C3b

16. Anti Scl 70 (DNA topo I
Chediak Higashi
Scleroderma diffuse
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Bruton's agamma

17. Where is MHC II expressed and and which HLA molecules codes for it
Mixed connective tissue disease
SCID
IFN gamma
APCs - and DR - DP and DQ

18. Anti ds DNA - anti Smith
C5b -9
Right arm and right half of head
SLE
Primary biliary cirrohosis

19. Which antibody (IgM or IgG) crosses the placenta?
IgG
IgE
SCID
Chronic: fibrosis of graft tissue and blood vessels

20. anti - Jo 1
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Hyper IgE syndrome (Job's)
Poly/dermato myositis
II

21. Which type of hypersens rxn is the arthus rxn
Poly/dermato myositis
III
Fab
Signal 1 = APC - signal 2 = B7 and CD28

22. Which MHC complex to CD4 cells bind
Howell - Jolly bodies - Target cells - thrombocytosis
MHC II 4 x 2=8
MS - hay fever - SLE - goodpasture's
III

23. What are the cytokines involved in macrophage/lymphocyte interaction
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Major shift minor drift
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

24. How are NK cells stimulated?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-12 - IFN- beta. IFN- alpha
Adaptive
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

25. Anticentromere
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Chronic granulomatous disease
DM type 1
Scleroderma CREST

26. Th cells don't produce IFN gamma - no PMN response

27. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Wegeners granulomatosis
Poly/dermato myositis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

28. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgG
MS - hay fever - SLE - goodpasture's
2

29. thwat does the Right lymphatic duct drain?
Right arm and right half of head
III
Ceilac disase
III

30. HLA- DR5
Hashimotos
Corticomedullary junction
Goodpastures
Pernicious anemia (to B12 def) - hashimotos thyroiditis

31. Deficiency in DAF
2
Hereditary angioedema
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Drug induced lupus

32. c - ANCA
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Wegeners granulomatosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Help B cells make antibody - secrete IFN gamma to activate macs

33. Defectin in isotype switching
Selective Ig def - IgA most common
III
Leukocyte adhesion deficiency type 1
Wegeners granulomatosis

34. Which type of hypersens rxn is antibody mediated?
II
Poly/dermato myositis
IgG - IgM GM makes classic cars
Chronic mucocutaneaous candidiasis

35. Defect in CD40L on helper T
Hyper IgM
Autoimmune hepatitis
Drug induced lupus
IL-12 - IFN- beta. IFN- alpha

36. Which antibody mediates type II and type III hypersens rxn
DM type 1
Chronic: fibrosis of graft tissue and blood vessels
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IgG

37. What are the 4 T's of type IV hypersense
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

38. Anti - IgG (RF)
RA
Perforin - granzyme - granulysin
IgG - IgM GM makes classic cars
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

39. What are the three APCs
Macs - dendritic cell - B cell
IL-12 def
Help B cells make antibody - secrete IFN gamma to activate macs
Right arm and right half of head

40. Defect in LFA-1 integrin CD18 protein on phagocytes
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
III
Leukocyte adhesion deficiency type 1
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

41. Which parasites exhibit antigenic variation
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Trypanosomes - programmed rearrangement
IgE
Autoimmune hepatitis

42. What is the role of CD4 cels
Ataxia telangectasia
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Help B cells make antibody - secrete IFN gamma to activate macs
IgE

43. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Ceilac disase
Everything else - not right arm and right half of head
Leukocyte adhesion deficiency type 1

44. HLA- B27

45. Which is the most abundant immunoglobulin in the blood?
Selective Ig def - IgA most common
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgG
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

46. Which areas of the body are drained by the axillary lymph node
S. aureus and S. pyogenes
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Upper limb and breast
RA - DM type 1

47. HLA- A3
Mixed connective tissue disease
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
B cell localization and proliferation
Hemochromocytosis

48. What is the unique cell marker for NK cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Autoimmune hepatitis
CD21
CD56

49. HLA- DR4
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Graves' dz
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
RA - DM type 1

50. What does a deficiency in C1 esterase inhibitor lead to?
Primary biliary cirrohosis
Upper limb and breast
Poly/dermato myositis
Hereditary angioedema