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Immunology

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Answer 50 questions in 15 minutes.
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1. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
II
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Everything else - not right arm and right half of head

2. What embryologic tissue are lymphcytes derived from
Mesenchyme
Everything else - not right arm and right half of head
Chronic mucocutaneaous candidiasis
DM type 1

3. What kind of bacteria do macrophages remove from the spleen?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Superficial inguinal pectinate line
IFN gamma

4. How are NK cells stimulated?
CD14
Wegeners granulomatosis
Trypanosomes - programmed rearrangement
IL-12 - IFN- beta. IFN- alpha

5. What do mature B lymphos express on their surface?
Sjorgen's syndrome
IgM and IgD
IL-10
SLE - nonspecific

6. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IL-2 and IFN gamma
Hyper IgE syndrome (Job's)
Superficial inguinal pectinate line

7. Which cytokines to Th1 cells secrete?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
S. aureus and S. pyogenes
IL-2 and IFN gamma

8. Where do positive and negative selection occur in the thymus?
DiGeorge
Major shift minor drift
Goodpastures
Corticomedullary junction

9. What are the 3 funxtions of antibodies?
SLE - nonspecific
Opsonization - neutralization and complement activation
IL-12 def
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

10. What are the 4 T's of type IV hypersense
CD8 cells
Ceilac disase
Stomach
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

11. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Mesenchyme
Scleroderma diffuse
Common variable immunodeficiency (CVID)

12. Which complement protein opsonizes bacteria?
C3b
MHC II 4 x 2=8
Hyperacute : occlusion - ischemia - necrosis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

13. Which type of hypersens rxn is antibody mediated?
III
II
SCID
Ataxia telangectasia

14. X linked recessive defect in BTK no B cell differentiation

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15. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
IgG
CD8 cells
DiGeorge
Drug induced lupus

16. thwat does the Right lymphatic duct drain?
IgE
Opsonization - neutralization and complement activation
Hashimotos
Right arm and right half of head

17. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
SCID
IFN gamma
Regulates the humoral response
Leukocyte adhesion deficiency type 1

18. Which receptor on MACS to endotoxin directy stimulate?
Adaptive
CD14
Trypanosomes - programmed rearrangement
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

19. What are the three APCs
Macs - dendritic cell - B cell
RA
MHC I
Stomach

20. antigliadin - antiendomysial
C5b -9
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
MHC I
Ceilac disase

21. Cell surface receptors on T cells
Mixed connective tissue disease
C5b -9
2
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

22. anti - Jo 1
Prevents attachment of bacteria and viruses to mucous membranes
Poly/dermato myositis
IgM
Il -4

23. What is the unique cell marker for NK cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
CD56

24. What do you find in the medulla of the thymus?
Signal 1 = APC - signal 2 = B7 and CD28
Hashimotos
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Primary biliary cirrohosis

25. What does the Th2 response do?
Hereditary angioedema
Ataxia telangectasia
Paracortex
Regulates the humoral response

26. HLA- DR4
IgG - IgM GM makes classic cars
RA - DM type 1
Hyperacute : occlusion - ischemia - necrosis
MHC I

27. Defect in B cell maturation
Hyper IgE syndrome (Job's)
IgA
IL-4 - 5 - 10
Common variable immunodeficiency (CVID)

28. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
MHC II 4 x 2=8
Leukocyte adhesion deficiency type 1
Chronic granulomatous disease
Superficial inguinal pectinate line

29. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
SCID
IL-10
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

30. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
IgM and IgD
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
B cell localization and proliferation
RA - DM type 1

31. What does the thoracic duct drain?
Ceilac disase
Everything else - not right arm and right half of head
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Poly/dermato myositis

32. Cell surface receptors on B cels
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Secondary
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Chediak Higashi

33. antidesmoglein
Poly/dermato myositis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Other vasculitidies
Pemphigus vulgaris

34. Anti - IgG (RF)
Opsonization - neutralization and complement activation
RA
Chediak Higashi
Paracortex

35. anti SS A/B or anti Ro/La

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36. What is the role of CD4 cels
SLE - nonspecific
III
Help B cells make antibody - secrete IFN gamma to activate macs
IgG

37. Which cytokine inhibits Th1 cells
Stomach
Opsonization - neutralization and complement activation
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IL-10

38. Th cells don't produce IFN gamma - no PMN response

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39. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Everything else - not right arm and right half of head
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MHC II 4 x 2=8

40. Antihistone
Ataxia telangectasia
IL-12
Sjorgen's syndrome
Drug induced lupus

41. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Chronic mucocutaneaous candidiasis
DM type 1

42. What cytokines to Th2 cells secrete?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-10
Mixed connective tissue disease
IL-4 - 5 - 10

43. Where is MHC II expressed and and which HLA molecules codes for it
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
APCs - and DR - DP and DQ
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Trypanosomes - programmed rearrangement

44. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
DM type 1
Perforin - granzyme - granulysin
Scleroderma diffuse

45. Anti Scl 70 (DNA topo I
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgE
Scleroderma diffuse

46. Deficiency in DAF
III
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Hashimotos
IgG - IgM GM makes classic cars

47. p - ANCA
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgG
Other vasculitidies
2

48. Which complement proteins make up the MAC
Macs - dendritic cell - B cell
C5b -9
CD40 and CD40L
SLE

49. Defect in CD40L on helper T
IV
Hyper IgM
DM type 1
IgE

50. anti glutamate decarboxylase
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Chronic mucocutaneaous candidiasis
DM type 1
IgG

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