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Immunology

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1. What is the clinical picture for serum sickness?
III
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
DM type 1
Leukocyte adhesion deficiency type 1

2. Where is MHC I expressed - and which HLA molecules code for it
Graves' dz
IgA
All nucleated cells (no RBCs) A - B - C
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

3. Which cytokines to Th1 cells secrete?
DM type 1
Chronic mucocutaneaous candidiasis
IL-2 and IFN gamma
CD56

4. Which is the receptors for EBV?
CD21
Steroid - responsive nephrotic syndrome
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

5. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
Superficial inguinal pectinate line
Fab
Perforin - granzyme - granulysin

6. Where do positive and negative selection occur in the thymus?
Hashimotos
Corticomedullary junction
PMNs recruited by IL-8 to clear infxns
Pernicious anemia (to B12 def) - hashimotos thyroiditis

7. HLA- DR5
Pernicious anemia (to B12 def) - hashimotos thyroiditis
C5b -9
Primary biliary cirrohosis
IgM and IgD

8. Which type of hypersens rxn is delayed
Steroid - responsive nephrotic syndrome
IV
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

9. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Chronic granulomatous disease
Hashimotos
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

10. What happens in the follicle of the lymph node
Leukocyte adhesion deficiency type 1
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
B cell localization and proliferation

11. anti - Jo 1
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgM and IgD
RA - DM type 1
Poly/dermato myositis

12. X- linked recessive defect with progessive deletion of B and T cells
SLE - nonspecific
Autoimmune hepatitis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IgG - IgM GM makes classic cars

13. Defect in B cell maturation
Common variable immunodeficiency (CVID)
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
2
Ataxia telangectasia

14. Where is MHC II expressed and and which HLA molecules codes for it
CD8 cells
APCs - and DR - DP and DQ
I
Hereditary angioedema

15. What inhibits Th2 cells
C3b
IFN gamma
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Fc

16. T cell dysfunction
Trypanosomes - programmed rearrangement
Chronic mucocutaneaous candidiasis
Pemphigus vulgaris
Leukocyte adhesion deficiency type 1

17. AR - defect in microtubule fxn with decreased phagocytosis
No - peptides only can can be presented on MHC molecules
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Chediak Higashi
Fc

18. anti basement membrane
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
III
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Goodpastures

19. transplant rejection: T cell and antibody mediated vasular damage
Goodpastures
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Chronic: fibrosis of graft tissue and blood vessels
IL-12 - IFN- beta. IFN- alpha

20. Which type of hypersens rxn is serum sickness?
CD40 and CD40L
All nucleated cells (no RBCs) A - B - C
IL-4 - 5 - 10
III

21. How do NK cells kill?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Drug induced lupus
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

22. How do CD8 cells kill?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Innate
Perforin - granzyme - granulysin
All nucleated cells (no RBCs) A - B - C

23. Which MHC complex to CD8 cells bind
MHC I
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
SLE
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

24. What interferes with viruses?
CD14
Hyperacute : occlusion - ischemia - necrosis
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Primary biliary cirrohosis

25. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
II
Help B cells make antibody - secrete IFN gamma to activate macs
SCID
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

26. What is the unique cell marker for NK cells
Everything else - not right arm and right half of head
CD56
Common variable immunodeficiency (CVID)
SCID

27. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
III
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
DM type 1

28. which follicles (primary or secondary) have active germinal centers?
Secondary
CD14
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Paracortex

29. Which parts of the antibody to light chain contribute
Fab
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
CD40 and CD40L
Common variable immunodeficiency (CVID)

30. Which type of hypersens rxn is antibody mediated?
Drug induced lupus
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Major shift minor drift
II

31. ANA
SLE - nonspecific
Stomach
Selective Ig def - IgA most common
IL-2 and IFN gamma

32. HLA- DR4
Adaptive
RA - DM type 1
Prevents attachment of bacteria and viruses to mucous membranes
Wegeners granulomatosis

33. Which complement proteins make up the MAC
No - peptides only can can be presented on MHC molecules
Pemphigus vulgaris
C5b -9
IFN gamma

34. Which bacteria secrete superantigen
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IgG - IgM GM makes classic cars
CD21
S. aureus and S. pyogenes

35. What do you find in the medulla of the thymus?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgG - IgM GM makes classic cars
SLE - nonspecific

36. Which antibody mediates type II and type III hypersens rxn
III
IgG
IgE
IL-2 and IFN gamma

37. What are the cell surface receptors on MACS
Pernicious anemia (to B12 def) - hashimotos thyroiditis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Mesenchyme
Steroid - responsive nephrotic syndrome

38. What kind of hypersens rxn in anaphylaxis
CD56
Hereditary angioedema
I
Mixed connective tissue disease

39. What is the difference in antigenic variation in viruses
Major shift minor drift
Superficial inguinal pectinate line
Regulates the humoral response
Perforin - granzyme - granulysin

40. Anticentromere
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Other vasculitidies
SLE - nonspecific
Scleroderma CREST

41. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
I
Hyper IgM
No - peptides only can can be presented on MHC molecules
CD14

42. What is the role of CD4 cels
CD40 and CD40L
Scleroderma diffuse
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Help B cells make antibody - secrete IFN gamma to activate macs

43. Which MHC complex to CD4 cells bind
IL-10
IgM
Hyper IgM
MHC II 4 x 2=8

44. Which areas of the body are drained by the axillary lymph node
Secondary
Hemochromocytosis
Upper limb and breast
Innate

45. Which cytokine induces Th1 cell profile in CD4 cells
Ceilac disase
III
IL-12
CD56

46. Anti ds DNA - anti Smith
III
SLE
MHC I
Bruton's agamma

47. anti glutamate decarboxylase
DM type 1
Scleroderma diffuse
RA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

48. antigliadin - antiendomysial
Ceilac disase
CD40 and CD40L
Upper limb and breast
Wegeners granulomatosis

49. Which cytokine inhibits Th1 cells
Steroid - responsive nephrotic syndrome
Signal 1 = APC - signal 2 = B7 and CD28
Poly/dermato myositis
IL-10

50. Which receptor on MACS to endotoxin directy stimulate?
CD14
Superficial inguinal pectinate line
Chediak Higashi
Hyperacute : occlusion - ischemia - necrosis

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