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Test your basic knowledge |
Immunology
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antimitochondrial
SLE
Primary biliary cirrohosis
Ataxia telangectasia
Fc and Fab
2. What cytokines to Th2 cells secrete?
IL-4 - 5 - 10
IgG
Hyper IgE syndrome (Job's)
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
3. What kind of hypersens rxn in anaphylaxis
I
Hyperacute : occlusion - ischemia - necrosis
Paracortex
CD56
4. Which antibodies activate the classic pathway
III
Paracortex
IL-4 - 5 - 10
IgG - IgM GM makes classic cars
5. What do mature B lymphos express on their surface?
IgM and IgD
Upper limb and breast
Pemphigus vulgaris
Mesenchyme
6. What is the role of CD4 cels
CD56
Adaptive
Primary biliary cirrohosis
Help B cells make antibody - secrete IFN gamma to activate macs
7. Anticentromere
IL-12 def
Scleroderma CREST
2
II
8. X linked recessive defect in BTK no B cell differentiation
9. What does a deficiency in C1 esterase inhibitor lead to?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
SLE - nonspecific
Hereditary angioedema
Hyper IgM
10. How do NK cells kill?
IgG
Goodpastures
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Pemphigus vulgaris
11. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Neisseria bacteremia
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
CD14
Mature t cells - epithelial reticular cells - Hassalls corpuscles
12. Which areas of the body are drained by the axillary lymph node
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Ataxia telangectasia
Upper limb and breast
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
13. What does the thoracic duct drain?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Upper limb and breast
Scleroderma diffuse
Everything else - not right arm and right half of head
14. What does clean up on Aisle 8 stand for?
Primary biliary cirrohosis
PMNs recruited by IL-8 to clear infxns
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
CD21
15. Which lymph node drains the anal canal below
Autoimmune hepatitis
Secondary
Superficial inguinal pectinate line
DiGeorge
16. X- linked recessive defect with progessive deletion of B and T cells
Ceilac disase
IFN gamma
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IV
17. antismooth muscle
CD8 cells
Autoimmune hepatitis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Corticomedullary junction
18. What interferes with viruses?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IV
DiGeorge
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
19. What embryologic tissue are lymphcytes derived from
Mesenchyme
Opsonization - neutralization and complement activation
Upper limb and breast
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
20. What are the three APCs
Macs - dendritic cell - B cell
Help B cells make antibody - secrete IFN gamma to activate macs
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
21. Defect in LFA-1 integrin CD18 protein on phagocytes
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Leukocyte adhesion deficiency type 1
Hyper IgM
22. Which receptor on MACS to endotoxin directy stimulate?
Il -4
C3b
CD14
Ceilac disase
23. Which parts of the antibody to heavy chain contribute?
CD56
IL-10
Fc and Fab
IgG
24. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Pemphigus vulgaris
Scleroderma CREST
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
25. Which B T cell interaction allows for immunologic memory and class switching?
Chronic mucocutaneaous candidiasis
Ataxia telangectasia
IgM
CD40 and CD40L
26. What does the Th2 response do?
IgG
Regulates the humoral response
Adaptive
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
27. transplant rejection: T cell and antibody mediated vasular damage
SLE - nonspecific
CD40 and CD40L
Chronic: fibrosis of graft tissue and blood vessels
IgG
28. Which cell mediates the type IV hypersens rxn?
CD21
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
CD8 cells
Graves' dz
29. Which type of hypersens rxn is immune complex mediate
III
Everything else - not right arm and right half of head
MS - hay fever - SLE - goodpasture's
MHC I
30. What do superantigens do?
CD56
III
Goodpastures
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
31. Antihistone
III
Regulates the humoral response
Drug induced lupus
MHC I
32. How many signals are required for T cell activation or B cell class switching?
Fab
IgE
2
Pernicious anemia (to B12 def) - hashimotos thyroiditis
33. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
Macs - dendritic cell - B cell
IgG - IgM GM makes classic cars
IFN gamma
34. What are the two signals required for B cells class switching?
Hashimotos
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
RA - DM type 1
Sjorgen's syndrome
35. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Fc and Fab
IgG
36. c - ANCA
IgG
Chediak Higashi
DiGeorge
Wegeners granulomatosis
37. Transplant rejection: preformed host antibody mediated
Prevents attachment of bacteria and viruses to mucous membranes
Hyperacute : occlusion - ischemia - necrosis
B cell localization and proliferation
Other vasculitidies
38. HLA- DR5
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IL-12 def
Pernicious anemia (to B12 def) - hashimotos thyroiditis
PMNs recruited by IL-8 to clear infxns
39. Which cytokines to Th1 cells secrete?
IL-12 - IFN- beta. IFN- alpha
Help B cells make antibody - secrete IFN gamma to activate macs
IgM
IL-2 and IFN gamma
40. anti SS A/B or anti Ro/La
41. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Scleroderma CREST
Prevents attachment of bacteria and viruses to mucous membranes
Innate
42. How do CD8 cells kill?
Autoimmune hepatitis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IgG
Perforin - granzyme - granulysin
43. HLA- D2
44. Which portion of the antibody determines the isotype
Fc
IgG
Hyper IgM
IL-12 def
45. AR - defect in microtubule fxn with decreased phagocytosis
C3b
Innate
Chediak Higashi
Steroid - responsive nephrotic syndrome
46. HLA- DR4
C5b -9
RA - DM type 1
IgG
Pemphigus vulgaris
47. Cell surface receptors on T cells
Prevents attachment of bacteria and viruses to mucous membranes
Scleroderma CREST
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IV
48. Defect in B cell maturation
Hashimotos
Common variable immunodeficiency (CVID)
Stomach
Hyper IgM
49. What are the two signals in cytotoxic T cells activation?
Perforin - granzyme - granulysin
Fc
Other vasculitidies
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
50. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Everything else - not right arm and right half of head
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Wegeners granulomatosis