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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What are the three APCs
Scleroderma CREST
Opsonization - neutralization and complement activation
Macs - dendritic cell - B cell
C3b

2. HLA- D2

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3. What do mature B lymphos express on their surface?
IgM and IgD
APCs - and DR - DP and DQ
B cell localization and proliferation
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

4. HLA- A3
Regulates the humoral response
Hemochromocytosis
Mixed connective tissue disease
B cell localization and proliferation

5. Deficiency in DAF
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IL-10
IgA
CD56

6. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
II
Paracortex
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

7. Which type of hypersens rxn is antibody mediated?
Neisseria bacteremia
Everything else - not right arm and right half of head
II
Hereditary angioedema

8. What is the main function of IgA
Chronic mucocutaneaous candidiasis
Prevents attachment of bacteria and viruses to mucous membranes
DM type 1
Opsonization - neutralization and complement activation

9. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
Mixed connective tissue disease
Mesenchyme
IgM and IgD

10. Anti - IgG (RF)
Poly/dermato myositis
RA
Hereditary angioedema
Howell - Jolly bodies - Target cells - thrombocytosis

11. Which MHC complex to CD4 cells bind
Major shift minor drift
IL-12 - IFN- beta. IFN- alpha
MHC II 4 x 2=8
IL-12

12. HLA- B27

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13. antidesmoglein
Howell - Jolly bodies - Target cells - thrombocytosis
Pemphigus vulgaris
S. aureus and S. pyogenes
Other vasculitidies

14. Which cytokine induces Th2 cell profile in CD4 cells
Superficial inguinal pectinate line
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Ataxia telangectasia
Il -4

15. What are the 3 funxtions of antibodies?
Opsonization - neutralization and complement activation
IgG
B cell localization and proliferation
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

16. HLA- DR4
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
RA - DM type 1
Macs - dendritic cell - B cell
IgG

17. What does clean up on Aisle 8 stand for?
Macs - dendritic cell - B cell
Steroid - responsive nephrotic syndrome
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
PMNs recruited by IL-8 to clear infxns

18. X- linked recessive defect with progessive deletion of B and T cells
Trypanosomes - programmed rearrangement
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Chronic granulomatous disease

19. What does a deficiency in C5- C8 lead to?
Secondary
IgM
Neisseria bacteremia
SLE

20. What are the cell surface receptors on MACS
III
Macs - dendritic cell - B cell
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

21. Anti Scl 70 (DNA topo I
Scleroderma diffuse
IV
Howell - Jolly bodies - Target cells - thrombocytosis
Wegeners granulomatosis

22. anti glutamate decarboxylase
Hereditary angioedema
DM type 1
MHC I
Paracortex

23. Which kind of immunity is germline encoded?
Neisseria bacteremia
B cell localization and proliferation
Innate
Upper limb and breast

24. c - ANCA
Wegeners granulomatosis
Mature t cells - epithelial reticular cells - Hassalls corpuscles
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

25. Which parasites exhibit antigenic variation
B cell localization and proliferation
Fab
Trypanosomes - programmed rearrangement
Major shift minor drift

26. What do superantigens do?
Chediak Higashi
IgG
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
III

27. anti U1 RNP
Trypanosomes - programmed rearrangement
Mixed connective tissue disease
Primary biliary cirrohosis
Prevents attachment of bacteria and viruses to mucous membranes

28. Which cytokine inhibits Th1 cells
Primary biliary cirrohosis
IL-10
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Il -4

29. What do you find in the medulla of the thymus?
CD21
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Chediak Higashi
SLE

30. antigliadin - antiendomysial
Ceilac disase
2
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Hyper IgE syndrome (Job's)

31. Which antibody mediates a type Hypersens rxn?
Major shift minor drift
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IgE

32. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Hereditary angioedema
IgG - IgM GM makes classic cars
Graves' dz

33. AR - defect in microtubule fxn with decreased phagocytosis
Stomach
Chediak Higashi
SLE - nonspecific
RA

34. What inhibits Th2 cells
Fc
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Signal 1 = APC - signal 2 = B7 and CD28
IFN gamma

35. Which MHC complex to CD8 cells bind
III
IL-2 and IFN gamma
DM type 1
MHC I

36. What cytokines to Th2 cells secrete?
APCs - and DR - DP and DQ
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IL-4 - 5 - 10
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

37. What are the 4 T's of type IV hypersense
RA - DM type 1
Selective Ig def - IgA most common
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
APCs - and DR - DP and DQ

38. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
Innate
III
No - peptides only can can be presented on MHC molecules

39. What does the thoracic duct drain?
Everything else - not right arm and right half of head
Hyperacute : occlusion - ischemia - necrosis
Perforin - granzyme - granulysin
Scleroderma diffuse

40. Defect in DNA repair enzymes
Prevents attachment of bacteria and viruses to mucous membranes
Graves' dz
Secondary
Ataxia telangectasia

41. Which lymph node drains the anal canal below
Superficial inguinal pectinate line
Upper limb and breast
IgA
MHC I

42. which follicles (primary or secondary) have active germinal centers?
Hyper IgM
Innate
Secondary
IL-12

43. Which type of hypersens rxn is serum sickness?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Chediak Higashi
III
Sjorgen's syndrome

44. Where do positive and negative selection occur in the thymus?
Hashimotos
Corticomedullary junction
SLE - nonspecific
IgM and IgD

45. What does a deficiency in C1 esterase inhibitor lead to?
Secondary
Major shift minor drift
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Hereditary angioedema

46. X linked recessive defect in BTK no B cell differentiation

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47. What does the Th2 response do?
Regulates the humoral response
IL-4 - 5 - 10
Mixed connective tissue disease
Corticomedullary junction

48. p - ANCA
All nucleated cells (no RBCs) A - B - C
Other vasculitidies
Superficial inguinal pectinate line
Innate

49. Which antibody (IgM or IgG) crosses the placenta?
IgG
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Mesenchyme
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

50. Cell surface receptors on T cells
Macs - dendritic cell - B cell
Mesenchyme
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Poly/dermato myositis