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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
CD8 cells
IL-10
RA

2. Which type of hypersens rxn is the arthus rxn
Hereditary angioedema
III
SCID
All nucleated cells (no RBCs) A - B - C

3. HLA- B27

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4. Anti ds DNA - anti Smith
SLE
Selective Ig def - IgA most common
IgM
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

5. anti - Jo 1
Perforin - granzyme - granulysin
Poly/dermato myositis
I
Mature t cells - epithelial reticular cells - Hassalls corpuscles

6. What does HOT- T- Bone stEAk stand for?
CD21
Common variable immunodeficiency (CVID)
IL-4 - 5 - 10
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

7. p - ANCA
SLE - nonspecific
Other vasculitidies
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Opsonization - neutralization and complement activation

8. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Other vasculitidies
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgA
Steroid - responsive nephrotic syndrome

9. transplant rejection: T cell and antibody mediated vasular damage
Mesenchyme
Chronic: fibrosis of graft tissue and blood vessels
IgM and IgD
SLE

10. Defect in B cell maturation
Chronic: fibrosis of graft tissue and blood vessels
Hashimotos
Everything else - not right arm and right half of head
Common variable immunodeficiency (CVID)

11. What are the two signals in cytotoxic T cells activation?
Fc and Fab
DM type 1
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

12. decreased Th1 response
Selective Ig def - IgA most common
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IL-12 def
Right arm and right half of head

13. anti SS A/B or anti Ro/La

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14. Which antibody (IgM or IgG) crosses the placenta?
Poly/dermato myositis
IgG
Signal 1 = APC - signal 2 = B7 and CD28
Other vasculitidies

15. Cell surface receptors on B cels
MS - hay fever - SLE - goodpasture's
Innate
MHC I
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

16. What are the three APCs
Upper limb and breast
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Macs - dendritic cell - B cell
III

17. What does the Th2 response do?
Regulates the humoral response
Paracortex
Trypanosomes - programmed rearrangement
Mesenchyme

18. What is the difference in antigenic variation in viruses
Major shift minor drift
Mixed connective tissue disease
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
II

19. HLA- A3
Hemochromocytosis
IgG - IgM GM makes classic cars
Stomach
CD14

20. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
III
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Hyperacute : occlusion - ischemia - necrosis

21. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Chediak Higashi
SLE - nonspecific
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

22. Defectin in isotype switching
IgA
CD8 cells
Selective Ig def - IgA most common
Fc and Fab

23. What does the thoracic duct drain?
MHC II 4 x 2=8
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Hereditary angioedema
Everything else - not right arm and right half of head

24. Antimitochondrial
Paracortex
Primary biliary cirrohosis
Secondary
Hyper IgM

25. Which infections require administering passive immunity?
Hyper IgE syndrome (Job's)
No - peptides only can can be presented on MHC molecules
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

26. What is the unique cell marker for NK cells
CD56
Chronic: fibrosis of graft tissue and blood vessels
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
RA - DM type 1

27. Which cytokine induces Th1 cell profile in CD4 cells
Superficial inguinal pectinate line
Regulates the humoral response
CD14
IL-12

28. What do mature B lymphos express on their surface?
IgG
DM type 1
IgM and IgD
Regulates the humoral response

29. Where do positive and negative selection occur in the thymus?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Corticomedullary junction
IL-2 and IFN gamma
Help B cells make antibody - secrete IFN gamma to activate macs

30. Which type of hypersens rxn is antibody mediated?
II
IgG
Opsonization - neutralization and complement activation
Signal 1 = APC - signal 2 = B7 and CD28

31. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
Fab
Autoimmune hepatitis
Everything else - not right arm and right half of head

32. Which lymph node drains the anal canal below
Superficial inguinal pectinate line
Macs - dendritic cell - B cell
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Mixed connective tissue disease

33. antimicrosomal - antithyroglobulin
Hashimotos
Wegeners granulomatosis
IV
Mature t cells - epithelial reticular cells - Hassalls corpuscles

34. X linked recessive defect in BTK no B cell differentiation

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35. Defect in DNA repair enzymes
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Ataxia telangectasia
Corticomedullary junction

36. anti glutamate decarboxylase
Hereditary angioedema
DM type 1
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Pemphigus vulgaris

37. What does a deficiency in C3 lead to...
IgE
Ceilac disase
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Selective Ig def - IgA most common

38. Which is the most abundant immunoglobulin in the blood?
Other vasculitidies
CD21
Neisseria bacteremia
IgG

39. antismooth muscle
Prevents attachment of bacteria and viruses to mucous membranes
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Howell - Jolly bodies - Target cells - thrombocytosis
Autoimmune hepatitis

40. X- linked recessive defect with progessive deletion of B and T cells
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Hereditary angioedema
Secondary

41. which areas of the body are drained by the celiac lymph node?
C3b
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Stomach
Fc

42. What are the two signals required for B cells class switching?
Poly/dermato myositis
IgG - IgM GM makes classic cars
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IgE

43. What cytokines to Th2 cells secrete?
CD8 cells
Ceilac disase
IL-4 - 5 - 10
IL-12

44. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Wegeners granulomatosis
SLE
No - peptides only can can be presented on MHC molecules
IgG

45. thwat does the Right lymphatic duct drain?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Hyper IgM
Right arm and right half of head
Everything else - not right arm and right half of head

46. which follicles (primary or secondary) have active germinal centers?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Secondary
DM type 1

47. Anticentromere
Scleroderma CREST
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Graves' dz
Goodpastures

48. Which cytokine inhibits Th1 cells
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Prevents attachment of bacteria and viruses to mucous membranes
IL-10
S. aureus and S. pyogenes

49. anti basement membrane
Other vasculitidies
Goodpastures
Bruton's agamma
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

50. Which type of hypersens rxn is serum sickness?
III
Leukocyte adhesion deficiency type 1
CD8 cells
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II