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Immunology

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Answer 50 questions in 15 minutes.
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1. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Chronic: fibrosis of graft tissue and blood vessels
Hyperacute : occlusion - ischemia - necrosis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Ceilac disase

2. What is the unique cell marker for NK cells
Ceilac disase
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
III
CD56

3. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
SLE - nonspecific
III
Ceilac disase

4. Which parts of the antibody to heavy chain contribute?
Mixed connective tissue disease
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
RA - DM type 1
Fc and Fab

5. How many signals are required for T cell activation or B cell class switching?
Ceilac disase
All nucleated cells (no RBCs) A - B - C
2
SLE - nonspecific

6. HLA- A3
Hemochromocytosis
CD21
Superficial inguinal pectinate line
DM type 1

7. Which immunoglobulin is a pentamer
Hemochromocytosis
III
Opsonization - neutralization and complement activation
IgM

8. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
IgG
IL-12
Hyperacute : occlusion - ischemia - necrosis

9. HLA- DR7
Neisseria bacteremia
Steroid - responsive nephrotic syndrome
Poly/dermato myositis
S. aureus and S. pyogenes

10. HLA- B27

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11. What is the role of CD4 cels
I
Help B cells make antibody - secrete IFN gamma to activate macs
Trypanosomes - programmed rearrangement
IgG

12. Where do positive and negative selection occur in the thymus?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Corticomedullary junction
Superficial inguinal pectinate line
RA - DM type 1

13. Anti ds DNA - anti Smith
Help B cells make antibody - secrete IFN gamma to activate macs
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
SLE
Primary biliary cirrohosis

14. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
Upper limb and breast
Help B cells make antibody - secrete IFN gamma to activate macs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

15. What does the thoracic duct drain?
Fc
Everything else - not right arm and right half of head
Hyper IgM
Paracortex

16. What is the main function of IgA
Sjorgen's syndrome
Prevents attachment of bacteria and viruses to mucous membranes
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Major shift minor drift

17. decreased Th1 response
IL-12 def
IL-12
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
CD40 and CD40L

18. HLA- B8

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19. anti glutamate decarboxylase
Hashimotos
DM type 1
Sjorgen's syndrome
IgA

20. Which complement proteins make up the MAC
CD8 cells
Pernicious anemia (to B12 def) - hashimotos thyroiditis
C5b -9
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

21. What cytokines to Th2 cells secrete?
IL-4 - 5 - 10
Other vasculitidies
Bruton's agamma
IL-12

22. which areas of the body are drained by the celiac lymph node?
Bruton's agamma
Stomach
Scleroderma CREST
RA

23. How are NK cells stimulated?
Autoimmune hepatitis
IL-12 - IFN- beta. IFN- alpha
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IgM

24. Which type of hypersens rxn is serum sickness?
RA - DM type 1
I
III
CD21

25. Which kind of immunity is germline encoded?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Hyper IgM
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Innate

26. Which portion of the antibody determines the isotype
Paracortex
SLE
IL-12 - IFN- beta. IFN- alpha
Fc

27. Which type of hypersens rxn is immune complex mediate
III
IL-10
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG

28. Which is the most abundant immunoglobulin in the blood?
Poly/dermato myositis
Hyper IgM
S. aureus and S. pyogenes
IgG

29. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-2 and IFN gamma
IgE
Upper limb and breast

30. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Mesenchyme
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

31. Which antibody mediates a type Hypersens rxn?
Goodpastures
IgE
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
2

32. What does a deficiency in C1 esterase inhibitor lead to?
Selective Ig def - IgA most common
Macs - dendritic cell - B cell
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Hereditary angioedema

33. c - ANCA
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Wegeners granulomatosis
Steroid - responsive nephrotic syndrome
Common variable immunodeficiency (CVID)

34. Cell surface receptors on T cells
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
C5b -9
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

35. Cell surface receptors on B cels
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Drug induced lupus
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Chronic mucocutaneaous candidiasis

36. Antihistone
Everything else - not right arm and right half of head
Drug induced lupus
Perforin - granzyme - granulysin
Common variable immunodeficiency (CVID)

37. Which B T cell interaction allows for immunologic memory and class switching?
RA
CD40 and CD40L
Chronic granulomatous disease
Perforin - granzyme - granulysin

38. What do you find in the medulla of the thymus?
CD8 cells
Paracortex
Macs - dendritic cell - B cell
Mature t cells - epithelial reticular cells - Hassalls corpuscles

39. thwat does the Right lymphatic duct drain?
Corticomedullary junction
Signal 1 = APC - signal 2 = B7 and CD28
IL-2 and IFN gamma
Right arm and right half of head

40. What kind of hypersens rxn in anaphylaxis
Howell - Jolly bodies - Target cells - thrombocytosis
Hyperacute : occlusion - ischemia - necrosis
CD21
I

41. HLA- DR3
PMNs recruited by IL-8 to clear infxns
Mesenchyme
IL-12 - IFN- beta. IFN- alpha
DM type 1

42. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IgE
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Regulates the humoral response

43. anti - Jo 1
Corticomedullary junction
Poly/dermato myositis
Selective Ig def - IgA most common
Trypanosomes - programmed rearrangement

44. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Ceilac disase
Chronic granulomatous disease
Drug induced lupus
MHC II 4 x 2=8

45. What happens in the follicle of the lymph node
Sjorgen's syndrome
Chronic mucocutaneaous candidiasis
Hemochromocytosis
B cell localization and proliferation

46. antimicrosomal - antithyroglobulin
IgG
Chronic: fibrosis of graft tissue and blood vessels
S. aureus and S. pyogenes
Hashimotos

47. What are the three things you find post splenectomy
Major shift minor drift
Howell - Jolly bodies - Target cells - thrombocytosis
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Chronic: fibrosis of graft tissue and blood vessels

48. Which parts of the antibody to light chain contribute
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Fab
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Innate

49. What are the three APCs
Upper limb and breast
Adaptive
Macs - dendritic cell - B cell
Signal 1 = APC - signal 2 = B7 and CD28

50. What are the cytokines involved in macrophage/lymphocyte interaction
B cell localization and proliferation
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IgE
Superficial inguinal pectinate line

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