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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. What do superantigens do?
Primary biliary cirrohosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Perforin - granzyme - granulysin
Mixed connective tissue disease

2. Cell surface receptors on B cels
SLE
MHC I
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
C5b -9

3. Defect in CD40L on helper T
Upper limb and breast
Autoimmune hepatitis
DM type 1
Hyper IgM

4. Anticentromere
DM type 1
Help B cells make antibody - secrete IFN gamma to activate macs
IgE
Scleroderma CREST

5. Antimitochondrial
IL-10
SLE - nonspecific
C5b -9
Primary biliary cirrohosis

6. Which receptor on MACS to endotoxin directy stimulate?
IFN gamma
CD21
Hyperacute : occlusion - ischemia - necrosis
CD14

7. Which type of hypersens rxn is delayed
IV
Scleroderma diffuse
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
No - peptides only can can be presented on MHC molecules

8. What does HOT- T- Bone stEAk stand for?
Hyper IgE syndrome (Job's)
APCs - and DR - DP and DQ
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Everything else - not right arm and right half of head

9. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
SCID
Fc
Ataxia telangectasia
Hereditary angioedema

10. anti glutamate decarboxylase
IL-12 def
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IL-12 - IFN- beta. IFN- alpha
DM type 1

11. Which is the most abundant immunoglobulin in the blood?
IL-12 - IFN- beta. IFN- alpha
Selective Ig def - IgA most common
Hyper IgE syndrome (Job's)
IgG

12. What are the 3 funxtions of antibodies?
Common variable immunodeficiency (CVID)
Paracortex
SLE - nonspecific
Opsonization - neutralization and complement activation

13. Which parts of the antibody to heavy chain contribute?
Common variable immunodeficiency (CVID)
C3b
Opsonization - neutralization and complement activation
Fc and Fab

14. What inhibits Th2 cells
All nucleated cells (no RBCs) A - B - C
IFN gamma
Leukocyte adhesion deficiency type 1
IgA

15. Which is the receptors for EBV?
C3b
Paracortex
CD21
Mesenchyme

16. Antihistone
Hyper IgE syndrome (Job's)
Regulates the humoral response
B cell localization and proliferation
Drug induced lupus

17. X linked recessive defect in BTK no B cell differentiation

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18. Anti ds DNA - anti Smith
Goodpastures
Hyperacute : occlusion - ischemia - necrosis
SLE
IgG

19. Deficiency in DAF
Chediak Higashi
RA - DM type 1
IgG
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

20. Which area of the lymph node englarges in an extreme immune response
Other vasculitidies
Paracortex
Fab
IFN gamma

21. What do mature B lymphos express on their surface?
IgM and IgD
RA - DM type 1
IL-12
Hyper IgM

22. What happens in the follicle of the lymph node
B cell localization and proliferation
III
Prevents attachment of bacteria and viruses to mucous membranes
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

23. What does the thoracic duct drain?
Hemochromocytosis
Prevents attachment of bacteria and viruses to mucous membranes
Everything else - not right arm and right half of head
Drug induced lupus

24. HLA- B27

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25. What interferes with viruses?
Chronic: fibrosis of graft tissue and blood vessels
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IL-12 def
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

26. Which immunoglobulin is a pentamer
IgM
II
All nucleated cells (no RBCs) A - B - C
CD14

27. T cell dysfunction
S. aureus and S. pyogenes
Right arm and right half of head
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Chronic mucocutaneaous candidiasis

28. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
Hyper IgM
Goodpastures
B cell localization and proliferation

29. which kind of immunity is characterized by receptors that undergo VDJ recombination?
No - peptides only can can be presented on MHC molecules
Pemphigus vulgaris
Adaptive
Scleroderma diffuse

30. Anti Scl 70 (DNA topo I
Drug induced lupus
Scleroderma diffuse
Fc
APCs - and DR - DP and DQ

31. What are the two signals required for B cells class switching?
IL-10
Primary biliary cirrohosis
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
CD40 and CD40L

32. Which antibodies activate the classic pathway
Upper limb and breast
MHC II 4 x 2=8
IgG
IgG - IgM GM makes classic cars

33. Which cytokine inhibits Th1 cells
Chronic granulomatous disease
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IL-12 def
IL-10

34. ANA
Ceilac disase
Secondary
IgG
SLE - nonspecific

35. thwat does the Right lymphatic duct drain?
Neisseria bacteremia
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Ataxia telangectasia
Right arm and right half of head

36. What does the Th2 response do?
Steroid - responsive nephrotic syndrome
Regulates the humoral response
IL-4 - 5 - 10
CD40 and CD40L

37. Which MHC complex to CD8 cells bind
Pemphigus vulgaris
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
MHC I
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

38. Which complement proteins make up the MAC
Selective Ig def - IgA most common
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
C5b -9
Neisseria bacteremia

39. HLA- DR4
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Paracortex
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
RA - DM type 1

40. Which cell mediates the type IV hypersens rxn?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
CD8 cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

41. What are the classic example of bacterial antigen variation and the unique mechanims
SCID
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IgM

42. What does a deficiency in C3 lead to...
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Right arm and right half of head
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Scleroderma CREST

43. Anti - IgG (RF)
Selective Ig def - IgA most common
Leukocyte adhesion deficiency type 1
Sjorgen's syndrome
RA

44. What embryologic tissue are lymphcytes derived from
Mesenchyme
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Chronic mucocutaneaous candidiasis

45. Which bacteria secrete superantigen
S. aureus and S. pyogenes
CD56
Chediak Higashi
Drug induced lupus

46. HLA- DR5
Pernicious anemia (to B12 def) - hashimotos thyroiditis
CD14
Drug induced lupus
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

47. anti - Jo 1
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Regulates the humoral response
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Poly/dermato myositis

48. Cell surface receptors on T cells
Wegeners granulomatosis
I
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
CD8 cells

49. What is the difference in antigenic variation in viruses
Trypanosomes - programmed rearrangement
Help B cells make antibody - secrete IFN gamma to activate macs
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Major shift minor drift

50. Which type of hypersens rxn is serum sickness?
DiGeorge
Superficial inguinal pectinate line
III
Neisseria bacteremia

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