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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Deficiency in DAF
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
II
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

2. Which parts of the antibody to light chain contribute
III
RA
Fab
IL-12 - IFN- beta. IFN- alpha

3. Anticentromere
IgE
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Scleroderma CREST
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

4. HLA- B27

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5. thwat does the Right lymphatic duct drain?
IV
Howell - Jolly bodies - Target cells - thrombocytosis
Right arm and right half of head
Innate

6. Which areas of the body are drained by the axillary lymph node
Primary biliary cirrohosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Everything else - not right arm and right half of head
Upper limb and breast

7. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Primary biliary cirrohosis
MHC I
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgA

8. antismooth muscle
Scleroderma diffuse
Autoimmune hepatitis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgG

9. What are the three APCs
Everything else - not right arm and right half of head
Macs - dendritic cell - B cell
Bruton's agamma
Major shift minor drift

10. What inhibits Th2 cells
CD21
Leukocyte adhesion deficiency type 1
IFN gamma
Upper limb and breast

11. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
Wegeners granulomatosis
Steroid - responsive nephrotic syndrome
Howell - Jolly bodies - Target cells - thrombocytosis

12. X linked recessive defect in BTK no B cell differentiation

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13. Which area of the lymph node englarges in an extreme immune response
Poly/dermato myositis
Hemochromocytosis
Paracortex
IgA

14. Anti - IgG (RF)
MHC II 4 x 2=8
RA
Paracortex
Major shift minor drift

15. which follicles (primary or secondary) have active germinal centers?
Major shift minor drift
Secondary
Fab
Ataxia telangectasia

16. What is the unique cell marker for NK cells
CD56
Major shift minor drift
Primary biliary cirrohosis
CD8 cells

17. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IgA
Drug induced lupus

18. HLA- DR4
Major shift minor drift
RA - DM type 1
Wegeners granulomatosis
SLE

19. What are the two signals required for B cells class switching?
Steroid - responsive nephrotic syndrome
Goodpastures
SLE
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

20. Which receptor on MACS to endotoxin directy stimulate?
CD14
Everything else - not right arm and right half of head
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Fc and Fab

21. decreased Th1 response
B cell localization and proliferation
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IL-12 def
Wegeners granulomatosis

22. What is the main function of IgA
Il -4
Prevents attachment of bacteria and viruses to mucous membranes
IL-10
IL-12

23. What do superantigens do?
Corticomedullary junction
Drug induced lupus
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
CD56

24. Which type of hypersens rxn is immune complex mediate
Right arm and right half of head
III
Wegeners granulomatosis
Chronic mucocutaneaous candidiasis

25. Which type of hypersens rxn is antibody mediated?
Fab
II
Stomach
Superficial inguinal pectinate line

26. Which is the receptors for EBV?
Ceilac disase
SLE - nonspecific
APCs - and DR - DP and DQ
CD21

27. Which is the most abundant immunoglobulin in the blood?
CD14
IgG
SLE - nonspecific
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

28. Which type of hypersens rxn is the arthus rxn
III
Hyper IgM
Major shift minor drift
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

29. What kind of hypersens rxn in anaphylaxis
I
IgG - IgM GM makes classic cars
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Signal 1 = APC - signal 2 = B7 and CD28

30. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
Stomach
All nucleated cells (no RBCs) A - B - C
IgM

31. Which type of hypersens rxn is serum sickness?
III
No - peptides only can can be presented on MHC molecules
Fc and Fab
Ataxia telangectasia

32. Which antibody (IgM or IgG) crosses the placenta?
Chronic: fibrosis of graft tissue and blood vessels
IgG
Fc
Hyperacute : occlusion - ischemia - necrosis

33. What are the classic example of bacterial antigen variation and the unique mechanims
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

34. anti U1 RNP
Ataxia telangectasia
Mixed connective tissue disease
RA
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

35. What are the two signals in helper T activation?
II
Signal 1 = APC - signal 2 = B7 and CD28
Superficial inguinal pectinate line
Fab

36. Which cytokine inhibits Th1 cells
IL-10
IL-12
Leukocyte adhesion deficiency type 1
Scleroderma CREST

37. What is the arthus rxn?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Mixed connective tissue disease
Scleroderma diffuse

38. T cell dysfunction
MS - hay fever - SLE - goodpasture's
Chronic mucocutaneaous candidiasis
IL-12 - IFN- beta. IFN- alpha
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

39. Which MHC complex to CD4 cells bind
Poly/dermato myositis
MHC II 4 x 2=8
Adaptive
PMNs recruited by IL-8 to clear infxns

40. Which cell mediates the type IV hypersens rxn?
Drug induced lupus
Paracortex
CD8 cells
Poly/dermato myositis

41. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Scleroderma CREST
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
CD56

42. anti glutamate decarboxylase
DM type 1
Autoimmune hepatitis
IL-12 def
Hashimotos

43. How do NK cells kill?
Paracortex
IL-12 - IFN- beta. IFN- alpha
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

44. Which cytokines to Th1 cells secrete?
IL-2 and IFN gamma
IL-12 - IFN- beta. IFN- alpha
Scleroderma diffuse
MHC II 4 x 2=8

45. X- linked recessive defect with progessive deletion of B and T cells
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Macs - dendritic cell - B cell
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Ceilac disase

46. Which type of hypersens rxn is delayed
Selective Ig def - IgA most common
Secondary
IV
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

47. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
Drug induced lupus
PMNs recruited by IL-8 to clear infxns
Regulates the humoral response

48. What are the 4 T's of type IV hypersense
IL-2 and IFN gamma
CD40 and CD40L
Graves' dz
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

49. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
Hemochromocytosis
Fab
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

50. What does a deficiency in C5- C8 lead to?
Hereditary angioedema
IgM and IgD
Everything else - not right arm and right half of head
Neisseria bacteremia