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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. antigliadin - antiendomysial
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Ceilac disase
IL-2 and IFN gamma
S. aureus and S. pyogenes

2. Which type of hypersens rxn is immune complex mediate
DiGeorge
III
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
C3b

3. Anti ds DNA - anti Smith
CD21
SLE
RA
Stomach

4. Th cells don't produce IFN gamma - no PMN response

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5. Defect in LFA-1 integrin CD18 protein on phagocytes
Major shift minor drift
Leukocyte adhesion deficiency type 1
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD56

6. What kind of hypersens rxn in anaphylaxis
I
Hyper IgE syndrome (Job's)
Sjorgen's syndrome
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

7. What are the two signals in helper T activation?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Innate
Signal 1 = APC - signal 2 = B7 and CD28
Selective Ig def - IgA most common

8. anti basement membrane
Goodpastures
Superficial inguinal pectinate line
Secondary
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

9. Anti - IgG (RF)
RA
Drug induced lupus
Signal 1 = APC - signal 2 = B7 and CD28
IgG

10. antismooth muscle
Chronic: fibrosis of graft tissue and blood vessels
Right arm and right half of head
Hashimotos
Autoimmune hepatitis

11. anti glutamate decarboxylase
DM type 1
PMNs recruited by IL-8 to clear infxns
II
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

12. What do you find in the medulla of the thymus?
DM type 1
Mature t cells - epithelial reticular cells - Hassalls corpuscles
DiGeorge
Fab

13. What are the two signals in cytotoxic T cells activation?
SLE
No - peptides only can can be presented on MHC molecules
II
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

14. HLA- DR5
Leukocyte adhesion deficiency type 1
SLE
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Pernicious anemia (to B12 def) - hashimotos thyroiditis

15. What is the difference in antigenic variation in viruses
Hashimotos
Secondary
CD21
Major shift minor drift

16. What is the role of CD4 cels
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Help B cells make antibody - secrete IFN gamma to activate macs
All nucleated cells (no RBCs) A - B - C
Adaptive

17. Which antibodies activate the classic pathway
Superficial inguinal pectinate line
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Major shift minor drift
IgG - IgM GM makes classic cars

18. antimicrosomal - antithyroglobulin
CD8 cells
Pemphigus vulgaris
Hashimotos
Fab

19. Which infections require administering passive immunity?
Selective Ig def - IgA most common
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Regulates the humoral response
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

20. anti U1 RNP
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Wegeners granulomatosis
Mixed connective tissue disease
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

21. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hereditary angioedema
II

22. Defectin in isotype switching
Selective Ig def - IgA most common
Ataxia telangectasia
Poly/dermato myositis
IgM and IgD

23. Which antibody mediates a type Hypersens rxn?
Other vasculitidies
CD14
IgE
IL-2 and IFN gamma

24. Which antibody (IgM or IgG) crosses the placenta?
Ceilac disase
IgG
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
RA

25. Which is the receptors for EBV?
No - peptides only can can be presented on MHC molecules
CD21
MHC I
Major shift minor drift

26. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Primary biliary cirrohosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Corticomedullary junction
Adaptive

27. anti SS A/B or anti Ro/La

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28. Defect in B cell maturation
IL-4 - 5 - 10
Prevents attachment of bacteria and viruses to mucous membranes
MHC I
Common variable immunodeficiency (CVID)

29. Deficiency in DAF
IFN gamma
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Fc and Fab
C3b

30. Anticentromere
Chronic: fibrosis of graft tissue and blood vessels
Scleroderma CREST
SCID
Mesenchyme

31. c - ANCA
Wegeners granulomatosis
IL-12 def
IFN gamma
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

32. What are the classic example of bacterial antigen variation and the unique mechanims
IgE
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
B cell localization and proliferation
C3b

33. Which MHC complex to CD8 cells bind
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Scleroderma diffuse
2
MHC I

34. What does the Th2 response do?
Chediak Higashi
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Regulates the humoral response
Hyper IgE syndrome (Job's)

35. What are the three things you find post splenectomy
IL-4 - 5 - 10
Hashimotos
Howell - Jolly bodies - Target cells - thrombocytosis
Prevents attachment of bacteria and viruses to mucous membranes

36. What are the 3 funxtions of antibodies?
Opsonization - neutralization and complement activation
II
DM type 1
IL-12

37. Which parts of the antibody to light chain contribute
Superficial inguinal pectinate line
Fab
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Selective Ig def - IgA most common

38. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
APCs - and DR - DP and DQ
IL-12 def
MHC I

39. anti - Jo 1
Poly/dermato myositis
MHC I
Mixed connective tissue disease
Paracortex

40. HLA- B8

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41. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Scleroderma CREST
Sjorgen's syndrome
IV

42. Which cytokine induces Th1 cell profile in CD4 cells
MHC II 4 x 2=8
CD8 cells
DM type 1
IL-12

43. T cell dysfunction
Chronic mucocutaneaous candidiasis
Upper limb and breast
IgG - IgM GM makes classic cars
Selective Ig def - IgA most common

44. thwat does the Right lymphatic duct drain?
MS - hay fever - SLE - goodpasture's
Regulates the humoral response
I
Right arm and right half of head

45. Which antibody mediates type II and type III hypersens rxn
IgG
Goodpastures
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

46. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
IL-2 and IFN gamma
Scleroderma diffuse
III

47. HLA- B27

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48. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Signal 1 = APC - signal 2 = B7 and CD28
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgG - IgM GM makes classic cars

49. Which bacteria secrete superantigen
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IgM and IgD
Poly/dermato myositis
S. aureus and S. pyogenes

50. What are the two signals required for B cells class switching?
Scleroderma diffuse
Chediak Higashi
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Hemochromocytosis