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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Anti Scl 70 (DNA topo I
Sjorgen's syndrome
Scleroderma diffuse
Hashimotos
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

2. T cell dysfunction
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Ataxia telangectasia
Chronic mucocutaneaous candidiasis

3. What does a deficiency in C5- C8 lead to?
IL-12 - IFN- beta. IFN- alpha
Neisseria bacteremia
Pemphigus vulgaris
B cell localization and proliferation

4. What are the three things you find post splenectomy
Howell - Jolly bodies - Target cells - thrombocytosis
IgG - IgM GM makes classic cars
SLE - nonspecific
Stomach

5. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Prevents attachment of bacteria and viruses to mucous membranes
No - peptides only can can be presented on MHC molecules

6. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Other vasculitidies
Fc
B cell localization and proliferation

7. Defect in DNA repair enzymes
Trypanosomes - programmed rearrangement
IgG
Ataxia telangectasia
IgG

8. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
DiGeorge
IgA
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

9. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Other vasculitidies
2

10. Which type of hypersens rxn is antibody mediated?
IL-10
II
Fc
IgG

11. Which is the most abundant immunoglobulin in the blood?
SLE - nonspecific
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Autoimmune hepatitis
IgG

12. HLA- DR4
RA - DM type 1
IV
Prevents attachment of bacteria and viruses to mucous membranes
IL-12 - IFN- beta. IFN- alpha

13. anti glutamate decarboxylase
CD14
Right arm and right half of head
DM type 1
MHC II 4 x 2=8

14. transplant rejection: T cell and antibody mediated vasular damage
MS - hay fever - SLE - goodpasture's
Chronic: fibrosis of graft tissue and blood vessels
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

15. p - ANCA
Wegeners granulomatosis
SLE - nonspecific
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Other vasculitidies

16. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
CD40 and CD40L
Regulates the humoral response
Scleroderma CREST

17. What are the two signals required for B cells class switching?
B cell localization and proliferation
IL-12
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Opsonization - neutralization and complement activation

18. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hemochromocytosis
Mixed connective tissue disease
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

19. What interferes with viruses?
SLE - nonspecific
No - peptides only can can be presented on MHC molecules
Chronic granulomatous disease
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

20. anti - Jo 1
MHC II 4 x 2=8
Poly/dermato myositis
Corticomedullary junction
Chronic mucocutaneaous candidiasis

21. Which parasites exhibit antigenic variation
Hemochromocytosis
Trypanosomes - programmed rearrangement
SLE
Hashimotos

22. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
CD14
Mixed connective tissue disease
SCID
Fab

23. Deficiency in DAF
Goodpastures
Mesenchyme
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

24. Which type of hypersens rxn is immune complex mediate
2
Fc and Fab
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
III

25. decreased Th1 response
Innate
IL-12 def
Selective Ig def - IgA most common
IL-2 and IFN gamma

26. antidesmoglein
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Pemphigus vulgaris
IgG - IgM GM makes classic cars
SCID

27. AR - defect in microtubule fxn with decreased phagocytosis
Neisseria bacteremia
Chediak Higashi
I
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

28. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Signal 1 = APC - signal 2 = B7 and CD28
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Howell - Jolly bodies - Target cells - thrombocytosis

29. What are the two signals in helper T activation?
Stomach
Goodpastures
Signal 1 = APC - signal 2 = B7 and CD28
Prevents attachment of bacteria and viruses to mucous membranes

30. Defect in B cell maturation
Hyperacute : occlusion - ischemia - necrosis
III
Drug induced lupus
Common variable immunodeficiency (CVID)

31. HLA- B8

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32. anti U1 RNP
Mesenchyme
Howell - Jolly bodies - Target cells - thrombocytosis
IgM
Mixed connective tissue disease

33. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Chronic granulomatous disease
Adaptive
Howell - Jolly bodies - Target cells - thrombocytosis
Ataxia telangectasia

34. Anti ds DNA - anti Smith
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
SLE
Chronic: fibrosis of graft tissue and blood vessels
III

35. What are the cytokines involved in macrophage/lymphocyte interaction
I
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
B cell localization and proliferation

36. How do CD8 cells kill?
Trypanosomes - programmed rearrangement
Perforin - granzyme - granulysin
Graves' dz
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

37. HLA- A3
IL-2 and IFN gamma
Autoimmune hepatitis
Hemochromocytosis
MHC II 4 x 2=8

38. which follicles (primary or secondary) have active germinal centers?
Secondary
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Adaptive
APCs - and DR - DP and DQ

39. What does a deficiency in C1 esterase inhibitor lead to?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Chronic mucocutaneaous candidiasis
Hereditary angioedema
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

40. What are the 4 T's of type IV hypersense
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Innate
Scleroderma diffuse
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

41. Which parts of the antibody to light chain contribute
Steroid - responsive nephrotic syndrome
Fab
Regulates the humoral response
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

42. Which cytokine inhibits Th1 cells
Il -4
IL-10
Primary biliary cirrohosis
Major shift minor drift

43. What is the arthus rxn?
MS - hay fever - SLE - goodpasture's
Chronic granulomatous disease
DM type 1
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

44. Which complement proteins make up the MAC
B cell localization and proliferation
IL-12 def
C5b -9
Macs - dendritic cell - B cell

45. Which bacteria secrete superantigen
MHC I
Ceilac disase
Ataxia telangectasia
S. aureus and S. pyogenes

46. anti basement membrane
Goodpastures
Innate
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Upper limb and breast

47. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
MS - hay fever - SLE - goodpasture's
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Leukocyte adhesion deficiency type 1

48. What kind of bacteria do macrophages remove from the spleen?
Selective Ig def - IgA most common
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

49. What do you find in the medulla of the thymus?
Everything else - not right arm and right half of head
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Hyper IgM
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

50. What inhibits Th2 cells
IFN gamma
Everything else - not right arm and right half of head
APCs - and DR - DP and DQ
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8