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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. HLA- DR3
Mixed connective tissue disease
CD56
Corticomedullary junction
DM type 1

2. Which antibody (IgM or IgG) crosses the placenta?
Hashimotos
Mesenchyme
Pemphigus vulgaris
IgG

3. AR - defect in microtubule fxn with decreased phagocytosis
Scleroderma diffuse
Trypanosomes - programmed rearrangement
Il -4
Chediak Higashi

4. Defect in DNA repair enzymes
Mature t cells - epithelial reticular cells - Hassalls corpuscles
RA
Ataxia telangectasia
Major shift minor drift

5. What is the unique cell marker for NK cells
CD56
DM type 1
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Upper limb and breast

6. What are the three APCs
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Macs - dendritic cell - B cell
Selective Ig def - IgA most common
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

7. What is the role of CD4 cels
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
RA
Help B cells make antibody - secrete IFN gamma to activate macs
IL-2 and IFN gamma

8. transplant rejection: T cell and antibody mediated vasular damage
IV
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Chronic: fibrosis of graft tissue and blood vessels

9. anti basement membrane
RA
2
Goodpastures
Scleroderma diffuse

10. What does the Th2 response do?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Regulates the humoral response
Corticomedullary junction
III

11. Which kind of immunity is germline encoded?
IV
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Innate

12. HLA- DR4
MHC I
RA - DM type 1
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
APCs - and DR - DP and DQ

13. What does a deficiency in C3 lead to...
CD21
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
SLE - nonspecific
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

14. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Leukocyte adhesion deficiency type 1
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

15. Which type of hypersens rxn is delayed
IgG - IgM GM makes classic cars
IV
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
No - peptides only can can be presented on MHC molecules

16. Which type of hypersens rxn is immune complex mediate
III
Scleroderma CREST
Bruton's agamma
IgG

17. What do mature B lymphos express on their surface?
C5b -9
Everything else - not right arm and right half of head
S. aureus and S. pyogenes
IgM and IgD

18. Which receptor on MACS to endotoxin directy stimulate?
No - peptides only can can be presented on MHC molecules
CD14
Mature t cells - epithelial reticular cells - Hassalls corpuscles
2

19. Which type of hypersens rxn is serum sickness?
Chronic mucocutaneaous candidiasis
Right arm and right half of head
III
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

20. Transplant rejection: preformed host antibody mediated
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
SLE
Ceilac disase
Hyperacute : occlusion - ischemia - necrosis

21. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Pernicious anemia (to B12 def) - hashimotos thyroiditis
SCID
IgM and IgD
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

22. antismooth muscle
MS - hay fever - SLE - goodpasture's
Autoimmune hepatitis
Common variable immunodeficiency (CVID)
Steroid - responsive nephrotic syndrome

23. ANA
Stomach
Ceilac disase
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
SLE - nonspecific

24. antimicrosomal - antithyroglobulin
Autoimmune hepatitis
Hashimotos
MS - hay fever - SLE - goodpasture's
Pemphigus vulgaris

25. What are the 4 T's of type IV hypersense
SCID
Other vasculitidies
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hereditary angioedema

26. What are the three things you find post splenectomy
Howell - Jolly bodies - Target cells - thrombocytosis
Scleroderma CREST
Upper limb and breast
Corticomedullary junction

27. anti - Jo 1
Adaptive
Poly/dermato myositis
Wegeners granulomatosis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

28. Th cells don't produce IFN gamma - no PMN response

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29. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Regulates the humoral response
IL-10
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Chronic granulomatous disease

30. What do you find in the medulla of the thymus?
No - peptides only can can be presented on MHC molecules
Howell - Jolly bodies - Target cells - thrombocytosis
Mature t cells - epithelial reticular cells - Hassalls corpuscles
MHC I

31. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
MS - hay fever - SLE - goodpasture's
Fc and Fab
IgA
SLE - nonspecific

32. Defect in CD40L on helper T
RA
Hyper IgM
Corticomedullary junction
Upper limb and breast

33. Which cell mediates the type IV hypersens rxn?
Selective Ig def - IgA most common
C3b
CD8 cells
Fc and Fab

34. X linked recessive defect in BTK no B cell differentiation

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35. HLA- DR7
Scleroderma diffuse
CD56
No - peptides only can can be presented on MHC molecules
Steroid - responsive nephrotic syndrome

36. antidesmoglein
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Chronic: fibrosis of graft tissue and blood vessels
Fc
Pemphigus vulgaris

37. HLA- B8

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38. Which antibody mediates a type Hypersens rxn?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
C3b
Everything else - not right arm and right half of head
IgE

39. Which bacteria secrete superantigen
S. aureus and S. pyogenes
CD40 and CD40L
Superficial inguinal pectinate line
IV

40. Which cytokine induces Th2 cell profile in CD4 cells
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IgG
Il -4
Pemphigus vulgaris

41. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Chronic granulomatous disease
CD56
Adaptive
Corticomedullary junction

42. Where is MHC I expressed - and which HLA molecules code for it
IL-10
All nucleated cells (no RBCs) A - B - C
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IL-2 and IFN gamma

43. What is the difference in antigenic variation in viruses
Hyperacute : occlusion - ischemia - necrosis
Chediak Higashi
Major shift minor drift
Perforin - granzyme - granulysin

44. Which immunoglobulin is a pentamer
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgM
Poly/dermato myositis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

45. How many signals are required for T cell activation or B cell class switching?
2
SLE
DiGeorge
CD40 and CD40L

46. Antihistone
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Drug induced lupus
Regulates the humoral response
IFN gamma

47. How are NK cells stimulated?
IgE
DM type 1
IL-12 - IFN- beta. IFN- alpha
Trypanosomes - programmed rearrangement

48. Which MHC complex to CD8 cells bind
Fc
SLE - nonspecific
MHC I
IgG

49. Where do positive and negative selection occur in the thymus?
Corticomedullary junction
Selective Ig def - IgA most common
Autoimmune hepatitis
Paracortex

50. What kind of bacteria do macrophages remove from the spleen?
III
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
PMNs recruited by IL-8 to clear infxns
Help B cells make antibody - secrete IFN gamma to activate macs