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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What does clean up on Aisle 8 stand for?
MHC I
IL-12
PMNs recruited by IL-8 to clear infxns
DiGeorge

2. Which type of hypersens rxn is serum sickness?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
III
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

3. Which immunoglobulin is a pentamer
IgM
IL-2 and IFN gamma
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
RA - DM type 1

4. Anticentromere
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Scleroderma CREST
Secondary
Chronic granulomatous disease

5. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Right arm and right half of head
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

6. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
Chronic: fibrosis of graft tissue and blood vessels
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Innate

7. HLA- DR5
Chronic: fibrosis of graft tissue and blood vessels
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Superficial inguinal pectinate line
Poly/dermato myositis

8. HLA- A3
Graves' dz
Leukocyte adhesion deficiency type 1
PMNs recruited by IL-8 to clear infxns
Hemochromocytosis

9. What is the unique cell marker for NK cells
CD56
Stomach
Chronic granulomatous disease
Wegeners granulomatosis

10. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Autoimmune hepatitis
DM type 1
Chronic granulomatous disease
Howell - Jolly bodies - Target cells - thrombocytosis

11. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
C5b -9
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Stomach

12. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Major shift minor drift
DiGeorge
PMNs recruited by IL-8 to clear infxns

13. Which antibody mediates a type Hypersens rxn?
Fc
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Hyperacute : occlusion - ischemia - necrosis
IgE

14. Which receptor on MACS to endotoxin directy stimulate?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Mesenchyme
CD14
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

15. anti - Jo 1
Hashimotos
Poly/dermato myositis
Howell - Jolly bodies - Target cells - thrombocytosis
C3b

16. How do NK cells kill?
IL-12 def
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Il -4
Neisseria bacteremia

17. HLA- D2

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18. Which cytokine inhibits Th1 cells
Hyper IgE syndrome (Job's)
CD40 and CD40L
DM type 1
IL-10

19. How do CD8 cells kill?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Perforin - granzyme - granulysin
Chronic granulomatous disease
IgG

20. decreased Th1 response
IL-12 def
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Major shift minor drift
Mixed connective tissue disease

21. What does the Th2 response do?
Hyper IgM
IgA
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Regulates the humoral response

22. Which bacteria secrete superantigen
IL-10
IV
S. aureus and S. pyogenes
Macs - dendritic cell - B cell

23. What inhibits Th2 cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IFN gamma
RA - DM type 1
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

24. What is the role of CD4 cels
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
C5b -9
Help B cells make antibody - secrete IFN gamma to activate macs
CD21

25. Which antibodies activate the classic pathway
Adaptive
Mesenchyme
IgA
IgG - IgM GM makes classic cars

26. which follicles (primary or secondary) have active germinal centers?
IgM and IgD
IL-12 - IFN- beta. IFN- alpha
Secondary
Fc and Fab

27. anti glutamate decarboxylase
IgM and IgD
DM type 1
Ataxia telangectasia
Right arm and right half of head

28. Anti - IgG (RF)
Hyper IgM
IFN gamma
RA
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

29. anti SS A/B or anti Ro/La

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30. HLA- DR7
Ataxia telangectasia
Poly/dermato myositis
Steroid - responsive nephrotic syndrome
Prevents attachment of bacteria and viruses to mucous membranes

31. Which complement proteins make up the MAC
Goodpastures
I
IL-10
C5b -9

32. X- linked recessive defect with progessive deletion of B and T cells
S. aureus and S. pyogenes
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Mature t cells - epithelial reticular cells - Hassalls corpuscles
RA

33. Cell surface receptors on T cells
Neisseria bacteremia
Drug induced lupus
CD40 and CD40L
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

34. Anti ds DNA - anti Smith
SLE
IL-12 def
Chronic granulomatous disease
2

35. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
Regulates the humoral response
DM type 1
IgG

36. Which type of hypersens rxn is delayed
No - peptides only can can be presented on MHC molecules
CD14
Fab
IV

37. Which type of hypersens rxn is the arthus rxn
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
III
Perforin - granzyme - granulysin
B cell localization and proliferation

38. What does a deficiency in C1 esterase inhibitor lead to?
Scleroderma CREST
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Hereditary angioedema
Hyper IgM

39. HLA- DR3
C5b -9
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
DM type 1
Corticomedullary junction

40. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
Autoimmune hepatitis
Primary biliary cirrohosis
S. aureus and S. pyogenes

41. What kind of hypersens rxn in anaphylaxis
B cell localization and proliferation
I
Hyperacute : occlusion - ischemia - necrosis
Major shift minor drift

42. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Howell - Jolly bodies - Target cells - thrombocytosis
Hemochromocytosis

43. Where is MHC I expressed - and which HLA molecules code for it
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
All nucleated cells (no RBCs) A - B - C
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

44. Defect in DNA repair enzymes
IL-2 and IFN gamma
Ataxia telangectasia
Sjorgen's syndrome
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

45. What are the three APCs
MHC I
Macs - dendritic cell - B cell
Secondary
DM type 1

46. What are the two signals in helper T activation?
IgG - IgM GM makes classic cars
Signal 1 = APC - signal 2 = B7 and CD28
PMNs recruited by IL-8 to clear infxns
IgG

47. Defectin in isotype switching
Scleroderma CREST
Selective Ig def - IgA most common
2
Bruton's agamma

48. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Right arm and right half of head
Hyper IgM
IgE

49. which kind of immunity is characterized by receptors that undergo VDJ recombination?
II
IgM
Adaptive
Fc and Fab

50. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Hashimotos
IgM and IgD
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA