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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. ANA
Goodpastures
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Hyper IgE syndrome (Job's)
SLE - nonspecific

2. anti U1 RNP
Mixed connective tissue disease
IL-12
Hyperacute : occlusion - ischemia - necrosis
Common variable immunodeficiency (CVID)

3. Antihistone
Drug induced lupus
Paracortex
Hyper IgM
C3b

4. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Hyper IgE syndrome (Job's)
IgG - IgM GM makes classic cars
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

5. Which cytokine inhibits Th1 cells
Hemochromocytosis
IL-10
Chronic mucocutaneaous candidiasis
Fc and Fab

6. Which type of hypersens rxn is the arthus rxn
IgG
III
CD56
SCID

7. What are the two signals required for B cells class switching?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IgG
No - peptides only can can be presented on MHC molecules

8. Which antibodies activate the classic pathway
IL-12 def
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IL-2 and IFN gamma
IgG - IgM GM makes classic cars

9. What do mature B lymphos express on their surface?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Steroid - responsive nephrotic syndrome
Chronic granulomatous disease
IgM and IgD

10. which kind of immunity is characterized by receptors that undergo VDJ recombination?
No - peptides only can can be presented on MHC molecules
Adaptive
B cell localization and proliferation
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

11. X- linked recessive defect with progessive deletion of B and T cells
Drug induced lupus
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Mixed connective tissue disease
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

12. Which type of hypersens rxn is immune complex mediate
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
I
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
III

13. Defect in B cell maturation
Common variable immunodeficiency (CVID)
Hyper IgE syndrome (Job's)
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Primary biliary cirrohosis

14. Cell surface receptors on T cells
IL-12 - IFN- beta. IFN- alpha
Upper limb and breast
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Regulates the humoral response

15. Which cytokine induces Th1 cell profile in CD4 cells
Secondary
IgG
IL-4 - 5 - 10
IL-12

16. anti SS A/B or anti Ro/La

17. Which complement protein opsonizes bacteria?
C3b
IL-12
SLE
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

18. What are the cell surface receptors on MACS
IgG
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Howell - Jolly bodies - Target cells - thrombocytosis
Trypanosomes - programmed rearrangement

19. Which antibody (IgM or IgG) crosses the placenta?
MHC II 4 x 2=8
IgG
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

20. HLA- B27

21. HLA- DR5
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Il -4
Macs - dendritic cell - B cell
Pernicious anemia (to B12 def) - hashimotos thyroiditis

22. What does a deficiency in C1 esterase inhibitor lead to?
IgM
Poly/dermato myositis
Hereditary angioedema
Hyper IgE syndrome (Job's)

23. T cell dysfunction
Neisseria bacteremia
Major shift minor drift
S. aureus and S. pyogenes
Chronic mucocutaneaous candidiasis

24. What do superantigens do?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Corticomedullary junction
CD8 cells
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

25. Th cells don't produce IFN gamma - no PMN response

26. How do CD8 cells kill?
Perforin - granzyme - granulysin
IgA
Superficial inguinal pectinate line
Poly/dermato myositis

27. HLA- DR7
IgE
Fc
Steroid - responsive nephrotic syndrome
CD56

28. anti glutamate decarboxylase
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
DM type 1
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Poly/dermato myositis

29. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
All nucleated cells (no RBCs) A - B - C
CD40 and CD40L
Macs - dendritic cell - B cell
IgA

30. Which MHC complex to CD4 cells bind
Ataxia telangectasia
Chronic granulomatous disease
MHC II 4 x 2=8
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

31. Which type of hypersens rxn is antibody mediated?
II
Superficial inguinal pectinate line
IgM and IgD
Pernicious anemia (to B12 def) - hashimotos thyroiditis

32. Deficiency in DAF
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Ataxia telangectasia

33. HLA- D2

34. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IFN gamma
SLE

35. What are the 4 T's of type IV hypersense
Right arm and right half of head
IL-4 - 5 - 10
Pemphigus vulgaris
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

36. What are the cytokines involved in macrophage/lymphocyte interaction
IV
C5b -9
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
2

37. What embryologic tissue are lymphcytes derived from
Superficial inguinal pectinate line
III
Poly/dermato myositis
Mesenchyme

38. Transplant rejection: preformed host antibody mediated
Macs - dendritic cell - B cell
DM type 1
Hyperacute : occlusion - ischemia - necrosis
II

39. antidesmoglein
II
Pemphigus vulgaris
Sjorgen's syndrome
Scleroderma diffuse

40. Which antibody mediates type II and type III hypersens rxn
Chronic granulomatous disease
IL-2 and IFN gamma
III
IgG

41. p - ANCA
2
Other vasculitidies
Chronic: fibrosis of graft tissue and blood vessels
III

42. X linked recessive defect in BTK no B cell differentiation

43. Which parts of the antibody to heavy chain contribute?
III
CD21
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Fc and Fab

44. What does the Th2 response do?
Regulates the humoral response
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
III
Right arm and right half of head

45. Which complement proteins make up the MAC
Drug induced lupus
C5b -9
CD21
Pernicious anemia (to B12 def) - hashimotos thyroiditis

46. What cytokines to Th2 cells secrete?
Scleroderma diffuse
Major shift minor drift
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IL-4 - 5 - 10

47. Which antibody mediates a type Hypersens rxn?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IgE
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

48. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Wegeners granulomatosis
Paracortex
Everything else - not right arm and right half of head

49. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
SCID
Other vasculitidies
Paracortex

50. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
CD8 cells
Scleroderma diffuse
No - peptides only can can be presented on MHC molecules
Hereditary angioedema