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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What are the 3 funxtions of antibodies?
Poly/dermato myositis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Opsonization - neutralization and complement activation
Scleroderma CREST

2. antigliadin - antiendomysial
Innate
Ceilac disase
I
No - peptides only can can be presented on MHC molecules

3. Which kind of immunity is germline encoded?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Innate
Fc and Fab
Pemphigus vulgaris

4. Antihistone
All nucleated cells (no RBCs) A - B - C
RA
Drug induced lupus
DM type 1

5. What happens in the follicle of the lymph node
Scleroderma CREST
B cell localization and proliferation
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
DiGeorge

6. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Scleroderma CREST
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

7. What do you find in the medulla of the thymus?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Hashimotos
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
S. aureus and S. pyogenes

8. c - ANCA
Hemochromocytosis
Wegeners granulomatosis
Opsonization - neutralization and complement activation
Scleroderma diffuse

9. Which is the most abundant immunoglobulin in the blood?
CD8 cells
Superficial inguinal pectinate line
IgG
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

10. Which areas of the body are drained by the axillary lymph node
MS - hay fever - SLE - goodpasture's
Upper limb and breast
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

11. What does the Th2 response do?
IL-12
Regulates the humoral response
Adaptive
APCs - and DR - DP and DQ

12. Which antibody (IgM or IgG) crosses the placenta?
IgG
Everything else - not right arm and right half of head
SLE - nonspecific
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

13. Which parts of the antibody to heavy chain contribute?
Hashimotos
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Prevents attachment of bacteria and viruses to mucous membranes
Fc and Fab

14. HLA- DR3
Regulates the humoral response
2
RA
DM type 1

15. What are the cell surface receptors on MACS
All nucleated cells (no RBCs) A - B - C
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Major shift minor drift
Hyperacute : occlusion - ischemia - necrosis

16. What embryologic tissue are lymphcytes derived from
Common variable immunodeficiency (CVID)
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Macs - dendritic cell - B cell
Mesenchyme

17. Anticentromere
Chediak Higashi
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Scleroderma CREST
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

18. anti - Jo 1
Bruton's agamma
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Poly/dermato myositis
Scleroderma diffuse

19. Anti ds DNA - anti Smith
SLE - nonspecific
SLE
Macs - dendritic cell - B cell
Goodpastures

20. Which parasites exhibit antigenic variation
MHC II 4 x 2=8
Scleroderma diffuse
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Trypanosomes - programmed rearrangement

21. Which complement protein opsonizes bacteria?
DiGeorge
C3b
IFN gamma
MHC II 4 x 2=8

22. HLA- DR4
Il -4
Other vasculitidies
CD56
RA - DM type 1

23. What are the two signals in cytotoxic T cells activation?
IgG
Graves' dz
Hereditary angioedema
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

24. Which cytokines to Th1 cells secrete?
IL-2 and IFN gamma
Fc
IgM and IgD
Hyperacute : occlusion - ischemia - necrosis

25. Which antibodies activate the classic pathway
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG - IgM GM makes classic cars
Fc
Leukocyte adhesion deficiency type 1

26. What does a deficiency in C1 esterase inhibitor lead to?
CD40 and CD40L
Selective Ig def - IgA most common
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Hereditary angioedema

27. X linked recessive defect in BTK no B cell differentiation

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28. decreased Th1 response
IL-12 def
Leukocyte adhesion deficiency type 1
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

29. HLA- B8

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30. Antimitochondrial
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Primary biliary cirrohosis
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

31. What do mature B lymphos express on their surface?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Prevents attachment of bacteria and viruses to mucous membranes
IgM and IgD

32. T cell dysfunction
Chronic mucocutaneaous candidiasis
Superficial inguinal pectinate line
Hyper IgE syndrome (Job's)
CD56

33. What does a deficiency in C5- C8 lead to?
RA - DM type 1
Neisseria bacteremia
DM type 1
Prevents attachment of bacteria and viruses to mucous membranes

34. Where is MHC II expressed and and which HLA molecules codes for it
Superficial inguinal pectinate line
APCs - and DR - DP and DQ
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
MHC II 4 x 2=8

35. Which B T cell interaction allows for immunologic memory and class switching?
RA - DM type 1
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
CD40 and CD40L
Hyperacute : occlusion - ischemia - necrosis

36. anti basement membrane
Goodpastures
Superficial inguinal pectinate line
SCID
Selective Ig def - IgA most common

37. What do superantigens do?
CD21
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Sjorgen's syndrome
Fc

38. What cytokines to Th2 cells secrete?
SCID
IV
C3b
IL-4 - 5 - 10

39. which follicles (primary or secondary) have active germinal centers?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Prevents attachment of bacteria and viruses to mucous membranes
Secondary
SCID

40. Deficiency in DAF
2
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Sjorgen's syndrome
Ceilac disase

41. What are the three APCs
IgM
RA
PMNs recruited by IL-8 to clear infxns
Macs - dendritic cell - B cell

42. Which cytokine inhibits Th1 cells
RA - DM type 1
Stomach
IL-10
Hereditary angioedema

43. thwat does the Right lymphatic duct drain?
Right arm and right half of head
Stomach
Superficial inguinal pectinate line
Prevents attachment of bacteria and viruses to mucous membranes

44. Which type of hypersens rxn is serum sickness?
CD56
III
Fc
Primary biliary cirrohosis

45. Which complement proteins make up the MAC
PMNs recruited by IL-8 to clear infxns
Leukocyte adhesion deficiency type 1
C5b -9
Adaptive

46. What inhibits Th2 cells
Graves' dz
IFN gamma
DiGeorge
Hyper IgE syndrome (Job's)

47. Which lymph node drains the anal canal below
IgG - IgM GM makes classic cars
Hyperacute : occlusion - ischemia - necrosis
Drug induced lupus
Superficial inguinal pectinate line

48. Transplant rejection: preformed host antibody mediated
DM type 1
Hyperacute : occlusion - ischemia - necrosis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hashimotos

49. anti SS A/B or anti Ro/La

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50. Which immunoglobulin is a pentamer
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Wegeners granulomatosis
IgM
Bruton's agamma