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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which MHC complex to CD8 cells bind
MHC I
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Drug induced lupus
Stomach

2. Cell surface receptors on T cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgM and IgD
CD8 cells

3. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Mixed connective tissue disease
DM type 1
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgA

4. What is the unique cell marker for NK cells
Chronic mucocutaneaous candidiasis
C3b
CD56
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

5. Where do positive and negative selection occur in the thymus?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Corticomedullary junction
Hyper IgM
Secondary

6. Deficiency in DAF
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Fc
IgA
Scleroderma diffuse

7. What happens in the follicle of the lymph node
B cell localization and proliferation
Paracortex
Mesenchyme
Other vasculitidies

8. Which portion of the antibody determines the isotype
Fc
DM type 1
Signal 1 = APC - signal 2 = B7 and CD28
Macs - dendritic cell - B cell

9. Which antibody mediates a type Hypersens rxn?
I
All nucleated cells (no RBCs) A - B - C
IgE
Macs - dendritic cell - B cell

10. anti basement membrane
APCs - and DR - DP and DQ
IL-12 - IFN- beta. IFN- alpha
Goodpastures
Adaptive

11. HLA- D2

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12. HLA- B8

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13. Anti - IgG (RF)
Primary biliary cirrohosis
Il -4
CD14
RA

14. Defect in B cell maturation
Common variable immunodeficiency (CVID)
III
Hemochromocytosis
Goodpastures

15. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Ceilac disase
Hashimotos
Adaptive

16. antigliadin - antiendomysial
All nucleated cells (no RBCs) A - B - C
IL-4 - 5 - 10
Ceilac disase
Opsonization - neutralization and complement activation

17. antidesmoglein
All nucleated cells (no RBCs) A - B - C
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Pemphigus vulgaris
Hyper IgE syndrome (Job's)

18. X- linked recessive defect with progessive deletion of B and T cells
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

19. Which type of hypersens rxn is delayed
Leukocyte adhesion deficiency type 1
IgG - IgM GM makes classic cars
Paracortex
IV

20. HLA- B27

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21. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IV
Hemochromocytosis
SLE - nonspecific

22. ANA
SLE - nonspecific
Opsonization - neutralization and complement activation
IL-4 - 5 - 10
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

23. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Mesenchyme
IgE
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

24. antismooth muscle
Secondary
Hyperacute : occlusion - ischemia - necrosis
Autoimmune hepatitis
Neisseria bacteremia

25. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
I
Mixed connective tissue disease

26. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Superficial inguinal pectinate line
Right arm and right half of head
CD40 and CD40L
SCID

27. HLA- DR3
CD21
Signal 1 = APC - signal 2 = B7 and CD28
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
DM type 1

28. X linked recessive defect in BTK no B cell differentiation

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29. transplant rejection: T cell and antibody mediated vasular damage
Fab
Pemphigus vulgaris
Chronic: fibrosis of graft tissue and blood vessels
CD14

30. How many signals are required for T cell activation or B cell class switching?
Wegeners granulomatosis
2
PMNs recruited by IL-8 to clear infxns
IgG

31. Which type of hypersens rxn is the arthus rxn
Major shift minor drift
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
III

32. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
I
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Chronic mucocutaneaous candidiasis

33. Which type of hypersens rxn is immune complex mediate
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
All nucleated cells (no RBCs) A - B - C
III
IgG

34. Which bacteria secrete superantigen
Hemochromocytosis
S. aureus and S. pyogenes
III
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

35. Which parasites exhibit antigenic variation
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Trypanosomes - programmed rearrangement
Graves' dz
III

36. Which complement proteins make up the MAC
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
C5b -9
APCs - and DR - DP and DQ
Steroid - responsive nephrotic syndrome

37. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
C3b
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Chronic granulomatous disease
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

38. Which parts of the antibody to light chain contribute
IV
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Fab
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

39. What embryologic tissue are lymphcytes derived from
Drug induced lupus
Mesenchyme
Superficial inguinal pectinate line
Fab

40. What is the arthus rxn?
Paracortex
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Selective Ig def - IgA most common
CD56

41. Which cytokine inhibits Th1 cells
Help B cells make antibody - secrete IFN gamma to activate macs
Adaptive
IL-10
IgM

42. Which infections require administering passive immunity?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
SLE - nonspecific
IgG - IgM GM makes classic cars

43. antimicrosomal - antithyroglobulin
II
I
Hashimotos
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

44. What are the two signals in helper T activation?
Primary biliary cirrohosis
IL-10
Signal 1 = APC - signal 2 = B7 and CD28
Scleroderma diffuse

45. anti U1 RNP
Mixed connective tissue disease
Howell - Jolly bodies - Target cells - thrombocytosis
CD14
Upper limb and breast

46. Which type of hypersens rxn is antibody mediated?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgM
IV
II

47. anti - Jo 1
Poly/dermato myositis
I
IFN gamma
No - peptides only can can be presented on MHC molecules

48. What are the classic example of bacterial antigen variation and the unique mechanims
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-10
Right arm and right half of head
SLE - nonspecific

49. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Prevents attachment of bacteria and viruses to mucous membranes
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

50. What is the clinical picture for serum sickness?
Bruton's agamma
IgG
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Trypanosomes - programmed rearrangement