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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What are the cytokines involved in macrophage/lymphocyte interaction
Hemochromocytosis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Upper limb and breast
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

2. Antihistone
Prevents attachment of bacteria and viruses to mucous membranes
Drug induced lupus
Neisseria bacteremia
Macs - dendritic cell - B cell

3. What does a deficiency in C5- C8 lead to?
III
Primary biliary cirrohosis
Mesenchyme
Neisseria bacteremia

4. Transplant rejection: preformed host antibody mediated
Hereditary angioedema
Hyperacute : occlusion - ischemia - necrosis
Chronic: fibrosis of graft tissue and blood vessels
IgM and IgD

5. What is the role of CD4 cels
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Help B cells make antibody - secrete IFN gamma to activate macs
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Pemphigus vulgaris

6. How are NK cells stimulated?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IL-12 - IFN- beta. IFN- alpha
IgE
Pemphigus vulgaris

7. Defect in B cell maturation
Common variable immunodeficiency (CVID)
IL-12 def
PMNs recruited by IL-8 to clear infxns
Hyper IgE syndrome (Job's)

8. Defect in CD40L on helper T
SCID
Hyper IgM
Major shift minor drift
Howell - Jolly bodies - Target cells - thrombocytosis

9. Anticentromere
Mixed connective tissue disease
Autoimmune hepatitis
IL-2 and IFN gamma
Scleroderma CREST

10. What do superantigens do?
IV
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Mature t cells - epithelial reticular cells - Hassalls corpuscles

11. What is the unique cell marker for NK cells
Pemphigus vulgaris
CD56
IgG
Prevents attachment of bacteria and viruses to mucous membranes

12. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgA
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Mature t cells - epithelial reticular cells - Hassalls corpuscles

13. antismooth muscle
CD21
Corticomedullary junction
Right arm and right half of head
Autoimmune hepatitis

14. What do you find in the medulla of the thymus?
Steroid - responsive nephrotic syndrome
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Drug induced lupus
Fc and Fab

15. antimicrosomal - antithyroglobulin
S. aureus and S. pyogenes
III
Hashimotos
Graves' dz

16. What do mature B lymphos express on their surface?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
SCID
IgM and IgD
III

17. Antimitochondrial
DM type 1
Il -4
Macs - dendritic cell - B cell
Primary biliary cirrohosis

18. What inhibits Th2 cells
Superficial inguinal pectinate line
Pemphigus vulgaris
Hyperacute : occlusion - ischemia - necrosis
IFN gamma

19. What is the clinical picture for serum sickness?
Howell - Jolly bodies - Target cells - thrombocytosis
Regulates the humoral response
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Trypanosomes - programmed rearrangement

20. Which cytokine inhibits Th1 cells
Fc and Fab
CD40 and CD40L
IL-10
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

21. Which parasites exhibit antigenic variation
Superficial inguinal pectinate line
Trypanosomes - programmed rearrangement
B cell localization and proliferation
IL-10

22. What are the three APCs
APCs - and DR - DP and DQ
Macs - dendritic cell - B cell
Ceilac disase
Drug induced lupus

23. How many signals are required for T cell activation or B cell class switching?
III
Mesenchyme
2
Steroid - responsive nephrotic syndrome

24. antigliadin - antiendomysial
Hyperacute : occlusion - ischemia - necrosis
Steroid - responsive nephrotic syndrome
Ceilac disase
Hyper IgE syndrome (Job's)

25. What happens in the follicle of the lymph node
Opsonization - neutralization and complement activation
B cell localization and proliferation
Secondary
Steroid - responsive nephrotic syndrome

26. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
PMNs recruited by IL-8 to clear infxns
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgA
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

27. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
CD21
Drug induced lupus
IFN gamma
SCID

28. Which complement protein opsonizes bacteria?
Right arm and right half of head
MHC I
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
C3b

29. What is the arthus rxn?
Fc and Fab
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Signal 1 = APC - signal 2 = B7 and CD28
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

30. anti U1 RNP
Mixed connective tissue disease
Scleroderma diffuse
Scleroderma CREST
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

31. What does HOT- T- Bone stEAk stand for?
Mesenchyme
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Right arm and right half of head
IgG

32. Which type of hypersens rxn is antibody mediated?
II
III
All nucleated cells (no RBCs) A - B - C
Chronic mucocutaneaous candidiasis

33. What are the three things you find post splenectomy
C5b -9
Regulates the humoral response
Poly/dermato myositis
Howell - Jolly bodies - Target cells - thrombocytosis

34. What are the cell surface receptors on MACS
Right arm and right half of head
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Hereditary angioedema
MHC I

35. HLA- DR4
RA - DM type 1
CD40 and CD40L
IL-12
IgA

36. Deficiency in DAF
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Poly/dermato myositis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Superficial inguinal pectinate line

37. thwat does the Right lymphatic duct drain?
IgG
Hemochromocytosis
Corticomedullary junction
Right arm and right half of head

38. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
PMNs recruited by IL-8 to clear infxns
Superficial inguinal pectinate line
Il -4

39. Which type of hypersens rxn is delayed
Stomach
IV
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
I

40. What interferes with viruses?
Mixed connective tissue disease
SLE - nonspecific
SLE
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

41. Which area of the lymph node englarges in an extreme immune response
Mixed connective tissue disease
C5b -9
CD21
Paracortex

42. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
C3b
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Regulates the humoral response

43. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Il -4
Upper limb and breast

44. Which receptor on MACS to endotoxin directy stimulate?
CD14
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgG - IgM GM makes classic cars
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

45. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
IL-2 and IFN gamma
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Scleroderma diffuse
DiGeorge

46. Which MHC complex to CD8 cells bind
DiGeorge
MHC I
III
Common variable immunodeficiency (CVID)

47. Which type of hypersens rxn is serum sickness?
III
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Help B cells make antibody - secrete IFN gamma to activate macs
Chronic mucocutaneaous candidiasis

48. Which antibodies activate the classic pathway
Mixed connective tissue disease
S. aureus and S. pyogenes
Steroid - responsive nephrotic syndrome
IgG - IgM GM makes classic cars

49. antidesmoglein
Pemphigus vulgaris
PMNs recruited by IL-8 to clear infxns
Hyper IgE syndrome (Job's)
Fab

50. What are the two signals in helper T activation?
C3b
Signal 1 = APC - signal 2 = B7 and CD28
Regulates the humoral response
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn