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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Where is MHC II expressed and and which HLA molecules codes for it
Scleroderma CREST
B cell localization and proliferation
APCs - and DR - DP and DQ
IgG

2. anti - Jo 1
Poly/dermato myositis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IL-2 and IFN gamma

3. Which type of hypersens rxn is immune complex mediate
Regulates the humoral response
III
CD40 and CD40L
MHC I

4. Which area of the lymph node englarges in an extreme immune response
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
CD8 cells
Chronic: fibrosis of graft tissue and blood vessels
Paracortex

5. anti basement membrane
CD40 and CD40L
Perforin - granzyme - granulysin
Goodpastures
Fc

6. Defectin in isotype switching
Selective Ig def - IgA most common
Everything else - not right arm and right half of head
Hyper IgE syndrome (Job's)
III

7. What does a deficiency in C3 lead to...
S. aureus and S. pyogenes
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Chediak Higashi
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

8. HLA- D2

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9. X- linked recessive defect with progessive deletion of B and T cells
C5b -9
Upper limb and breast
Chronic: fibrosis of graft tissue and blood vessels
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

10. What is the main function of IgA
DiGeorge
Prevents attachment of bacteria and viruses to mucous membranes
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

11. Which antibodies activate the classic pathway
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Adaptive
IFN gamma
IgG - IgM GM makes classic cars

12. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
No - peptides only can can be presented on MHC molecules
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Selective Ig def - IgA most common
IgG

13. What cytokines to Th2 cells secrete?
Fc and Fab
IgG
Hereditary angioedema
IL-4 - 5 - 10

14. HLA- DR5
Hashimotos
Pernicious anemia (to B12 def) - hashimotos thyroiditis
APCs - and DR - DP and DQ
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

15. Antihistone
Other vasculitidies
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Drug induced lupus
Common variable immunodeficiency (CVID)

16. What do mature B lymphos express on their surface?
Hyper IgE syndrome (Job's)
Hyper IgM
IgM and IgD
Upper limb and breast

17. T cell dysfunction
Chronic mucocutaneaous candidiasis
C3b
Corticomedullary junction
Il -4

18. Which parts of the antibody to light chain contribute
SLE - nonspecific
Fab
MS - hay fever - SLE - goodpasture's
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

19. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
All nucleated cells (no RBCs) A - B - C
Chronic mucocutaneaous candidiasis
Opsonization - neutralization and complement activation

20. What is the role of CD4 cels
Poly/dermato myositis
Wegeners granulomatosis
Help B cells make antibody - secrete IFN gamma to activate macs
IgG

21. What embryologic tissue are lymphcytes derived from
Hemochromocytosis
RA - DM type 1
MS - hay fever - SLE - goodpasture's
Mesenchyme

22. Which portion of the antibody determines the isotype
IL-4 - 5 - 10
Fc
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Primary biliary cirrohosis

23. Which cell mediates the type IV hypersens rxn?
Neisseria bacteremia
Stomach
CD8 cells
IL-2 and IFN gamma

24. HLA- B27

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25. Anti - IgG (RF)
Fc and Fab
RA
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Hyperacute : occlusion - ischemia - necrosis

26. What does the Th2 response do?
IgM
Stomach
Opsonization - neutralization and complement activation
Regulates the humoral response

27. Which type of hypersens rxn is the arthus rxn
Primary biliary cirrohosis
III
IgE
Mature t cells - epithelial reticular cells - Hassalls corpuscles

28. What are the cell surface receptors on MACS
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Superficial inguinal pectinate line
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

29. Cell surface receptors on T cells
All nucleated cells (no RBCs) A - B - C
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
III
MHC I

30. Which antibody mediates type II and type III hypersens rxn
Fc and Fab
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgG

31. Which cytokine induces Th1 cell profile in CD4 cells
Ceilac disase
Primary biliary cirrohosis
IL-12
III

32. HLA- DR4
CD8 cells
Regulates the humoral response
SCID
RA - DM type 1

33. Which MHC complex to CD4 cells bind
MHC II 4 x 2=8
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
CD14

34. What does the thoracic duct drain?
2
Everything else - not right arm and right half of head
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Major shift minor drift

35. Anti Scl 70 (DNA topo I
Scleroderma diffuse
IgG
RA
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

36. which areas of the body are drained by the celiac lymph node?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Stomach
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
S. aureus and S. pyogenes

37. Which areas of the body are drained by the axillary lymph node
Regulates the humoral response
C3b
No - peptides only can can be presented on MHC molecules
Upper limb and breast

38. Which parasites exhibit antigenic variation
Fab
Scleroderma diffuse
Trypanosomes - programmed rearrangement
IgE

39. What are the two signals in cytotoxic T cells activation?
APCs - and DR - DP and DQ
Adaptive
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Mature t cells - epithelial reticular cells - Hassalls corpuscles

40. Which antibody mediates a type Hypersens rxn?
Innate
IgE
Hashimotos
Adaptive

41. Th cells don't produce IFN gamma - no PMN response

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42. What does a deficiency in C5- C8 lead to?
No - peptides only can can be presented on MHC molecules
Selective Ig def - IgA most common
Neisseria bacteremia
CD56

43. What is the arthus rxn?
IgM and IgD
Prevents attachment of bacteria and viruses to mucous membranes
2
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

44. anti glutamate decarboxylase
MHC I
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
DM type 1
Poly/dermato myositis

45. Which receptor on MACS to endotoxin directy stimulate?
Fab
Scleroderma CREST
I
CD14

46. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Scleroderma CREST
Stomach
Autoimmune hepatitis

47. Defect in B cell maturation
Adaptive
C3b
Innate
Common variable immunodeficiency (CVID)

48. Which infections require administering passive immunity?
Pemphigus vulgaris
Fc
Howell - Jolly bodies - Target cells - thrombocytosis
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

49. ANA
SLE - nonspecific
Scleroderma diffuse
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Selective Ig def - IgA most common

50. Transplant rejection: preformed host antibody mediated
Hyperacute : occlusion - ischemia - necrosis
Il -4
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Hereditary angioedema