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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which antibody (IgM or IgG) crosses the placenta?
Adaptive
IL-2 and IFN gamma
IgG
CD8 cells

2. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
SLE
Autoimmune hepatitis
PMNs recruited by IL-8 to clear infxns

3. ANA
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
SLE - nonspecific
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IL-12

4. Which type of hypersens rxn is delayed
SCID
Hereditary angioedema
IV
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

5. What inhibits Th2 cells
III
S. aureus and S. pyogenes
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IFN gamma

6. anti glutamate decarboxylase
DM type 1
IgM and IgD
Neisseria bacteremia
IgE

7. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
III
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Ceilac disase

8. Which receptor on MACS to endotoxin directy stimulate?
CD14
Trypanosomes - programmed rearrangement
SLE - nonspecific
Mature t cells - epithelial reticular cells - Hassalls corpuscles

9. X- linked recessive defect with progessive deletion of B and T cells
IL-12 def
CD40 and CD40L
Macs - dendritic cell - B cell
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

10. Defect in B cell maturation
IgM
Signal 1 = APC - signal 2 = B7 and CD28
SLE - nonspecific
Common variable immunodeficiency (CVID)

11. What are the 4 T's of type IV hypersense
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
RA - DM type 1
Scleroderma diffuse
Hyperacute : occlusion - ischemia - necrosis

12. which follicles (primary or secondary) have active germinal centers?
SLE
Trypanosomes - programmed rearrangement
Secondary
Wegeners granulomatosis

13. Which antibodies activate the classic pathway
Mesenchyme
IL-12 def
IgG - IgM GM makes classic cars
C5b -9

14. anti basement membrane
Ataxia telangectasia
Help B cells make antibody - secrete IFN gamma to activate macs
Goodpastures
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

15. What does the Th2 response do?
Regulates the humoral response
IgG
Neisseria bacteremia
Chronic: fibrosis of graft tissue and blood vessels

16. Which bacteria secrete superantigen
Mature t cells - epithelial reticular cells - Hassalls corpuscles
SLE - nonspecific
IgA
S. aureus and S. pyogenes

17. thwat does the Right lymphatic duct drain?
Mixed connective tissue disease
IgG - IgM GM makes classic cars
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Right arm and right half of head

18. What is the arthus rxn?
Mesenchyme
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Innate
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

19. Anti - IgG (RF)
RA
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

20. What does clean up on Aisle 8 stand for?
DM type 1
PMNs recruited by IL-8 to clear infxns
II
CD21

21. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Neisseria bacteremia
Adaptive

22. HLA- B27

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23. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
Fc
SLE
Secondary

24. Which parts of the antibody to heavy chain contribute?
Scleroderma CREST
Fc and Fab
Other vasculitidies
Ataxia telangectasia

25. Defect in DNA repair enzymes
IL-12 def
2
IV
Ataxia telangectasia

26. Where is MHC I expressed - and which HLA molecules code for it
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
All nucleated cells (no RBCs) A - B - C
Superficial inguinal pectinate line
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

27. antismooth muscle
Common variable immunodeficiency (CVID)
Fc
Autoimmune hepatitis
CD8 cells

28. Which cell mediates the type IV hypersens rxn?
Hyper IgM
CD8 cells
III
Scleroderma CREST

29. Which antibody mediates type II and type III hypersens rxn
IgG
Innate
III
Help B cells make antibody - secrete IFN gamma to activate macs

30. What are the classic example of bacterial antigen variation and the unique mechanims
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-12
Hereditary angioedema

31. HLA- DR3
Signal 1 = APC - signal 2 = B7 and CD28
SCID
Mature t cells - epithelial reticular cells - Hassalls corpuscles
DM type 1

32. What kind of hypersens rxn in anaphylaxis
Chediak Higashi
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
I
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

33. Which MHC complex to CD4 cells bind
PMNs recruited by IL-8 to clear infxns
Graves' dz
IL-12
MHC II 4 x 2=8

34. Transplant rejection: preformed host antibody mediated
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Hyperacute : occlusion - ischemia - necrosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
SCID

35. What cytokines to Th2 cells secrete?
Common variable immunodeficiency (CVID)
IL-4 - 5 - 10
Drug induced lupus
II

36. Which antibody mediates a type Hypersens rxn?
Opsonization - neutralization and complement activation
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
II
IgE

37. Where is MHC II expressed and and which HLA molecules codes for it
Other vasculitidies
II
IgG
APCs - and DR - DP and DQ

38. Th cells don't produce IFN gamma - no PMN response

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39. Defectin in isotype switching
MHC I
Selective Ig def - IgA most common
Mature t cells - epithelial reticular cells - Hassalls corpuscles
2

40. T cell dysfunction
Trypanosomes - programmed rearrangement
Mesenchyme
Chronic mucocutaneaous candidiasis
IL-12 def

41. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
S. aureus and S. pyogenes
Ataxia telangectasia
Autoimmune hepatitis

42. What are the cytokines involved in macrophage/lymphocyte interaction
Neisseria bacteremia
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

43. anti U1 RNP
No - peptides only can can be presented on MHC molecules
Selective Ig def - IgA most common
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Mixed connective tissue disease

44. Which MHC complex to CD8 cells bind
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Common variable immunodeficiency (CVID)
Everything else - not right arm and right half of head
MHC I

45. Which cytokine induces Th1 cell profile in CD4 cells
Secondary
Upper limb and breast
IL-12
IgE

46. Deficiency in DAF
Chronic granulomatous disease
APCs - and DR - DP and DQ
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Paracortex

47. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
Signal 1 = APC - signal 2 = B7 and CD28
Opsonization - neutralization and complement activation
SLE

48. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Ataxia telangectasia
Bruton's agamma

49. Which area of the lymph node englarges in an extreme immune response
No - peptides only can can be presented on MHC molecules
IL-12 def
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Paracortex

50. decreased Th1 response
RA
MHC I
Opsonization - neutralization and complement activation
IL-12 def