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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which complement protein opsonizes bacteria?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
C3b
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hyper IgE syndrome (Job's)

2. What does the thoracic duct drain?
Everything else - not right arm and right half of head
CD8 cells
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Hereditary angioedema

3. Defect in CD40L on helper T
CD14
Perforin - granzyme - granulysin
CD56
Hyper IgM

4. Which antibody mediates a type Hypersens rxn?
Prevents attachment of bacteria and viruses to mucous membranes
Scleroderma diffuse
CD56
IgE

5. What is the clinical picture for serum sickness?
Ataxia telangectasia
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
SLE
II

6. What are the three APCs
Macs - dendritic cell - B cell
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
III
Neisseria bacteremia

7. Deficiency in DAF
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Superficial inguinal pectinate line

8. What kind of hypersens rxn in anaphylaxis
I
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Everything else - not right arm and right half of head
Regulates the humoral response

9. What do you find in the medulla of the thymus?
Ceilac disase
III
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

10. Defect in LFA-1 integrin CD18 protein on phagocytes
DM type 1
I
Fab
Leukocyte adhesion deficiency type 1

11. Which B T cell interaction allows for immunologic memory and class switching?
MS - hay fever - SLE - goodpasture's
CD40 and CD40L
SCID
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

12. What does a deficiency in C1 esterase inhibitor lead to?
IgG - IgM GM makes classic cars
IFN gamma
Prevents attachment of bacteria and viruses to mucous membranes
Hereditary angioedema

13. Which cytokine inhibits Th1 cells
II
IL-10
Secondary
CD8 cells

14. What is the difference in antigenic variation in viruses
Major shift minor drift
Howell - Jolly bodies - Target cells - thrombocytosis
Right arm and right half of head
IgM

15. Which cell mediates the type IV hypersens rxn?
Help B cells make antibody - secrete IFN gamma to activate macs
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-4 - 5 - 10
CD8 cells

16. Which is the most abundant immunoglobulin in the blood?
Howell - Jolly bodies - Target cells - thrombocytosis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
MHC I
IgG

17. Which cytokine induces Th2 cell profile in CD4 cells
Common variable immunodeficiency (CVID)
IgG - IgM GM makes classic cars
Chronic mucocutaneaous candidiasis
Il -4

18. Which type of hypersens rxn is the arthus rxn
III
Ceilac disase
CD56
Regulates the humoral response

19. antigliadin - antiendomysial
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-2 and IFN gamma
Ceilac disase
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

20. X- linked recessive defect with progessive deletion of B and T cells
Perforin - granzyme - granulysin
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Graves' dz
All nucleated cells (no RBCs) A - B - C

21. What happens in the follicle of the lymph node
CD40 and CD40L
Hyper IgM
B cell localization and proliferation
C5b -9

22. What cytokines to Th2 cells secrete?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IL-4 - 5 - 10
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

23. Th cells don't produce IFN gamma - no PMN response

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24. Antihistone
S. aureus and S. pyogenes
Hyper IgE syndrome (Job's)
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Drug induced lupus

25. Where is MHC I expressed - and which HLA molecules code for it
Chronic mucocutaneaous candidiasis
All nucleated cells (no RBCs) A - B - C
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Fc

26. What do mature B lymphos express on their surface?
Trypanosomes - programmed rearrangement
Sjorgen's syndrome
Hyper IgE syndrome (Job's)
IgM and IgD

27. Which MHC complex to CD8 cells bind
MHC I
2
Stomach
C5b -9

28. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
Opsonization - neutralization and complement activation
Perforin - granzyme - granulysin
Superficial inguinal pectinate line

29. HLA- DR7
Steroid - responsive nephrotic syndrome
Innate
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Neisseria bacteremia

30. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Innate
Opsonization - neutralization and complement activation
2

31. How are NK cells stimulated?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IgE
IL-12 - IFN- beta. IFN- alpha
Il -4

32. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
III
IgA
CD8 cells
DM type 1

33. What do superantigens do?
III
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Chronic granulomatous disease
DM type 1

34. How do CD8 cells kill?
Mixed connective tissue disease
Fc
APCs - and DR - DP and DQ
Perforin - granzyme - granulysin

35. What does a deficiency in C3 lead to...
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
MS - hay fever - SLE - goodpasture's

36. Which areas of the body are drained by the axillary lymph node
Mature t cells - epithelial reticular cells - Hassalls corpuscles
I
Upper limb and breast
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

37. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
IgA
Hereditary angioedema
III

38. antimicrosomal - antithyroglobulin
Hashimotos
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Chronic granulomatous disease

39. Which type of hypersens rxn is immune complex mediate
III
Hyper IgE syndrome (Job's)
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Poly/dermato myositis

40. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
SLE
III
Mixed connective tissue disease

41. Antimitochondrial
Primary biliary cirrohosis
APCs - and DR - DP and DQ
RA - DM type 1
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

42. HLA- B8

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43. What does HOT- T- Bone stEAk stand for?
SLE - nonspecific
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Primary biliary cirrohosis
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

44. Defectin in isotype switching
Selective Ig def - IgA most common
Hemochromocytosis
CD14
Opsonization - neutralization and complement activation

45. Anticentromere
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Chronic: fibrosis of graft tissue and blood vessels
Scleroderma CREST
Sjorgen's syndrome

46. Which parts of the antibody to light chain contribute
Fab
Goodpastures
Opsonization - neutralization and complement activation
Hyper IgE syndrome (Job's)

47. How do NK cells kill?
Stomach
IgM
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Sjorgen's syndrome

48. Anti ds DNA - anti Smith
SLE
I
IgA
DM type 1

49. What are the 4 T's of type IV hypersense
C5b -9
CD8 cells
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-12 def

50. Which kind of immunity is germline encoded?
SCID
Stomach
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Innate