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Immunology

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Answer 50 questions in 15 minutes.
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1. What kind of hypersens rxn in anaphylaxis
Sjorgen's syndrome
Hyper IgE syndrome (Job's)
I
II

2. Where is MHC I expressed - and which HLA molecules code for it
IgG
IgG - IgM GM makes classic cars
All nucleated cells (no RBCs) A - B - C
Mature t cells - epithelial reticular cells - Hassalls corpuscles

3. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
RA - DM type 1

4. thwat does the Right lymphatic duct drain?
Ataxia telangectasia
Il -4
Right arm and right half of head
Sjorgen's syndrome

5. anti - Jo 1
Corticomedullary junction
SLE
Poly/dermato myositis
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

6. Which is the receptors for EBV?
Major shift minor drift
CD21
C5b -9
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

7. anti basement membrane
Goodpastures
III
Sjorgen's syndrome
Upper limb and breast

8. Anti Scl 70 (DNA topo I
Fc
Scleroderma diffuse
Pemphigus vulgaris
Chronic: fibrosis of graft tissue and blood vessels

9. Which type of hypersens rxn is delayed
IV
IgM and IgD
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
RA - DM type 1

10. Which B T cell interaction allows for immunologic memory and class switching?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD40 and CD40L
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

11. Defect in B cell maturation
Chronic: fibrosis of graft tissue and blood vessels
Common variable immunodeficiency (CVID)
Il -4
CD8 cells

12. which follicles (primary or secondary) have active germinal centers?
Howell - Jolly bodies - Target cells - thrombocytosis
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Secondary

13. Which parasites exhibit antigenic variation
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IV
Trypanosomes - programmed rearrangement
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

14. HLA- B8

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15. What interferes with viruses?
IL-12 def
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

16. How do CD8 cells kill?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IgG
Ceilac disase
Perforin - granzyme - granulysin

17. Which type of hypersens rxn is the arthus rxn
Bruton's agamma
Chronic granulomatous disease
III
Scleroderma diffuse

18. Which MHC complex to CD4 cells bind
S. aureus and S. pyogenes
II
MHC II 4 x 2=8
Leukocyte adhesion deficiency type 1

19. Which portion of the antibody determines the isotype
Fc
Right arm and right half of head
Help B cells make antibody - secrete IFN gamma to activate macs
IgE

20. What do you find in the medulla of the thymus?
Everything else - not right arm and right half of head
CD14
Mature t cells - epithelial reticular cells - Hassalls corpuscles
CD8 cells

21. Which lymph node drains the anal canal below
CD40 and CD40L
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Primary biliary cirrohosis
Superficial inguinal pectinate line

22. What are the cell surface receptors on MACS
Corticomedullary junction
Prevents attachment of bacteria and viruses to mucous membranes
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Hyper IgM

23. p - ANCA
Right arm and right half of head
Other vasculitidies
C5b -9
Ataxia telangectasia

24. What is the main function of IgA
Autoimmune hepatitis
Right arm and right half of head
Everything else - not right arm and right half of head
Prevents attachment of bacteria and viruses to mucous membranes

25. antismooth muscle
Autoimmune hepatitis
III
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Leukocyte adhesion deficiency type 1

26. Transplant rejection: preformed host antibody mediated
IL-12
Hyperacute : occlusion - ischemia - necrosis
Trypanosomes - programmed rearrangement
IgM and IgD

27. Which antibody (IgM or IgG) crosses the placenta?
Hereditary angioedema
CD14
IgG
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

28. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
Leukocyte adhesion deficiency type 1
No - peptides only can can be presented on MHC molecules
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

29. What happens in the follicle of the lymph node
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Drug induced lupus
Steroid - responsive nephrotic syndrome
B cell localization and proliferation

30. Which bacteria secrete superantigen
Chediak Higashi
Opsonization - neutralization and complement activation
Mesenchyme
S. aureus and S. pyogenes

31. anti glutamate decarboxylase
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
DM type 1
Hyper IgE syndrome (Job's)
Help B cells make antibody - secrete IFN gamma to activate macs

32. Which cytokines to Th1 cells secrete?
Everything else - not right arm and right half of head
RA
IL-2 and IFN gamma
Other vasculitidies

33. AR - defect in microtubule fxn with decreased phagocytosis
III
IgG
Chediak Higashi
SCID

34. X linked recessive defect in BTK no B cell differentiation

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35. What is the arthus rxn?
Prevents attachment of bacteria and viruses to mucous membranes
Scleroderma diffuse
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

36. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
CD56
Hyper IgM
Steroid - responsive nephrotic syndrome

37. What does clean up on Aisle 8 stand for?
Mesenchyme
CD40 and CD40L
PMNs recruited by IL-8 to clear infxns
Fc and Fab

38. HLA- A3
IL-12 - IFN- beta. IFN- alpha
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Hemochromocytosis
Signal 1 = APC - signal 2 = B7 and CD28

39. What do mature B lymphos express on their surface?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Perforin - granzyme - granulysin
IgM and IgD

40. What are the 4 T's of type IV hypersense
Hyper IgE syndrome (Job's)
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IL-10
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

41. Which type of hypersens rxn is immune complex mediate
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Everything else - not right arm and right half of head
III
Perforin - granzyme - granulysin

42. Which areas of the body are drained by the axillary lymph node
Poly/dermato myositis
Upper limb and breast
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-12

43. Which immunoglobulin is a pentamer
IgM
Il -4
MHC I
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

44. What are the three things you find post splenectomy
Ceilac disase
Howell - Jolly bodies - Target cells - thrombocytosis
Upper limb and breast
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

45. What is the clinical picture for serum sickness?
No - peptides only can can be presented on MHC molecules
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Bruton's agamma
Pernicious anemia (to B12 def) - hashimotos thyroiditis

46. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Everything else - not right arm and right half of head
MHC II 4 x 2=8
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

47. T cell dysfunction
Upper limb and breast
Chronic mucocutaneaous candidiasis
Help B cells make antibody - secrete IFN gamma to activate macs
Mixed connective tissue disease

48. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
III
MHC I
Selective Ig def - IgA most common

49. Where do positive and negative selection occur in the thymus?
APCs - and DR - DP and DQ
Ataxia telangectasia
Corticomedullary junction
IL-12 def

50. HLA- DR5
IL-2 and IFN gamma
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Il -4
Chronic: fibrosis of graft tissue and blood vessels

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