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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which complement protein opsonizes bacteria?
DM type 1
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Corticomedullary junction
C3b

2. Which parts of the antibody to heavy chain contribute?
Fc and Fab
Wegeners granulomatosis
2
IgM and IgD

3. What are the three things you find post splenectomy
Chediak Higashi
IL-12
Fc
Howell - Jolly bodies - Target cells - thrombocytosis

4. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
MS - hay fever - SLE - goodpasture's
Adaptive
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IgA

5. Defect in CD40L on helper T
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Hyper IgM
Chronic mucocutaneaous candidiasis
IgG

6. What is the difference in antigenic variation in viruses
II
Major shift minor drift
IgE
Chronic mucocutaneaous candidiasis

7. Which type of hypersens rxn is serum sickness?
S. aureus and S. pyogenes
III
Regulates the humoral response
IgG

8. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Innate
C5b -9
Selective Ig def - IgA most common

9. What are the 3 funxtions of antibodies?
Primary biliary cirrohosis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Opsonization - neutralization and complement activation
MHC I

10. Which kind of immunity is germline encoded?
Innate
Sjorgen's syndrome
Scleroderma diffuse
Graves' dz

11. decreased Th1 response
IgG
Adaptive
Hyper IgM
IL-12 def

12. What embryologic tissue are lymphcytes derived from
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Mesenchyme
IL-4 - 5 - 10

13. Which type of hypersens rxn is antibody mediated?
II
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Fab
Fc

14. antigliadin - antiendomysial
Ceilac disase
Neisseria bacteremia
Hereditary angioedema
Corticomedullary junction

15. What is the arthus rxn?
Major shift minor drift
CD40 and CD40L
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Drug induced lupus

16. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
IV
Scleroderma diffuse
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Paracortex

17. thwat does the Right lymphatic duct drain?
Macs - dendritic cell - B cell
Right arm and right half of head
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
MS - hay fever - SLE - goodpasture's

18. Antimitochondrial
Major shift minor drift
Adaptive
Primary biliary cirrohosis
Help B cells make antibody - secrete IFN gamma to activate macs

19. What are the cytokines involved in macrophage/lymphocyte interaction
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Ceilac disase
Macs - dendritic cell - B cell
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

20. What does the Th2 response do?
IL-12 def
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Regulates the humoral response
SCID

21. anti glutamate decarboxylase
DM type 1
Ceilac disase
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

22. anti basement membrane
Common variable immunodeficiency (CVID)
IgM
Goodpastures
Fc

23. What are the two signals required for B cells class switching?
Upper limb and breast
PMNs recruited by IL-8 to clear infxns
Chediak Higashi
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

24. Which immunoglobulin is a pentamer
IgM
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Chronic: fibrosis of graft tissue and blood vessels
Hyperacute : occlusion - ischemia - necrosis

25. X- linked recessive defect with progessive deletion of B and T cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgE
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Major shift minor drift

26. Which area of the lymph node englarges in an extreme immune response
Regulates the humoral response
Drug induced lupus
IL-4 - 5 - 10
Paracortex

27. Which is the receptors for EBV?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
CD21
DiGeorge
Stomach

28. Anti - IgG (RF)
APCs - and DR - DP and DQ
RA
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
III

29. Transplant rejection: preformed host antibody mediated
Everything else - not right arm and right half of head
Hyperacute : occlusion - ischemia - necrosis
Perforin - granzyme - granulysin
Ceilac disase

30. p - ANCA
Other vasculitidies
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Graves' dz
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

31. HLA- DR3
Right arm and right half of head
DM type 1
Wegeners granulomatosis
Common variable immunodeficiency (CVID)

32. HLA- A3
Signal 1 = APC - signal 2 = B7 and CD28
Corticomedullary junction
Hemochromocytosis
MS - hay fever - SLE - goodpasture's

33. HLA- D2

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34. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
CD8 cells
DiGeorge
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Everything else - not right arm and right half of head

35. Which bacteria secrete superantigen
S. aureus and S. pyogenes
Scleroderma diffuse
MHC I
PMNs recruited by IL-8 to clear infxns

36. Defect in DNA repair enzymes
Goodpastures
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
CD21
Ataxia telangectasia

37. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
MHC II 4 x 2=8
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Pernicious anemia (to B12 def) - hashimotos thyroiditis

38. anti - Jo 1
Poly/dermato myositis
III
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

39. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Hereditary angioedema
DiGeorge
DM type 1
IL-4 - 5 - 10

40. What do superantigens do?
S. aureus and S. pyogenes
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Chronic: fibrosis of graft tissue and blood vessels
IgG

41. AR - defect in microtubule fxn with decreased phagocytosis
Pemphigus vulgaris
Help B cells make antibody - secrete IFN gamma to activate macs
IgG
Chediak Higashi

42. which areas of the body are drained by the celiac lymph node?
Chediak Higashi
Il -4
Stomach
MHC II 4 x 2=8

43. Which cytokine induces Th1 cell profile in CD4 cells
C5b -9
Common variable immunodeficiency (CVID)
IL-12
Hyperacute : occlusion - ischemia - necrosis

44. Defectin in isotype switching
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-2 and IFN gamma
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Selective Ig def - IgA most common

45. antismooth muscle
PMNs recruited by IL-8 to clear infxns
IgG
Autoimmune hepatitis
Hereditary angioedema

46. ANA
Other vasculitidies
Hashimotos
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
SLE - nonspecific

47. What is the role of CD4 cels
III
Perforin - granzyme - granulysin
IL-10
Help B cells make antibody - secrete IFN gamma to activate macs

48. What does a deficiency in C1 esterase inhibitor lead to?
Chronic mucocutaneaous candidiasis
Leukocyte adhesion deficiency type 1
Hereditary angioedema
C5b -9

49. Which MHC complex to CD4 cells bind
Corticomedullary junction
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
MHC II 4 x 2=8
Chronic granulomatous disease

50. Which is the most abundant immunoglobulin in the blood?
Secondary
Superficial inguinal pectinate line
IgG
Fc and Fab