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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. anti U1 RNP
Common variable immunodeficiency (CVID)
Mixed connective tissue disease
Il -4
Chronic mucocutaneaous candidiasis

2. Which lymph node drains the anal canal below
DM type 1
Superficial inguinal pectinate line
Paracortex
Fc

3. What are the two signals in helper T activation?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IL-10
RA - DM type 1
Signal 1 = APC - signal 2 = B7 and CD28

4. Antihistone
Drug induced lupus
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Autoimmune hepatitis
CD40 and CD40L

5. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
CD8 cells
Mesenchyme
Selective Ig def - IgA most common

6. Which parasites exhibit antigenic variation
Chediak Higashi
Trypanosomes - programmed rearrangement
CD56
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

7. decreased Th1 response
IL-12 def
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Drug induced lupus
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

8. How do NK cells kill?
Wegeners granulomatosis
Major shift minor drift
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

9. HLA- DR3
MS - hay fever - SLE - goodpasture's
Fc
Adaptive
DM type 1

10. HLA- B8

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11. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
Hereditary angioedema
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

12. Which portion of the antibody determines the isotype
IFN gamma
DM type 1
Fc
Innate

13. X- linked recessive defect with progessive deletion of B and T cells
Poly/dermato myositis
Common variable immunodeficiency (CVID)
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Mesenchyme

14. Which type of hypersens rxn is serum sickness?
IgG - IgM GM makes classic cars
Mixed connective tissue disease
III
Chronic: fibrosis of graft tissue and blood vessels

15. How many signals are required for T cell activation or B cell class switching?
Major shift minor drift
C3b
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
2

16. Defect in DNA repair enzymes
Prevents attachment of bacteria and viruses to mucous membranes
Ataxia telangectasia
Scleroderma CREST
IV

17. What are the 3 funxtions of antibodies?
DM type 1
IL-10
MS - hay fever - SLE - goodpasture's
Opsonization - neutralization and complement activation

18. Which type of hypersens rxn is immune complex mediate
Secondary
III
Hyperacute : occlusion - ischemia - necrosis
Sjorgen's syndrome

19. HLA- DR5
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Pernicious anemia (to B12 def) - hashimotos thyroiditis
III
Bruton's agamma

20. Which area of the lymph node englarges in an extreme immune response
Chediak Higashi
RA
B cell localization and proliferation
Paracortex

21. Anti - IgG (RF)
Scleroderma diffuse
Primary biliary cirrohosis
RA
CD56

22. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Leukocyte adhesion deficiency type 1
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

23. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
B cell localization and proliferation
Scleroderma CREST
SCID
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

24. Anti Scl 70 (DNA topo I
Scleroderma diffuse
APCs - and DR - DP and DQ
III
Pernicious anemia (to B12 def) - hashimotos thyroiditis

25. X linked recessive defect in BTK no B cell differentiation

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26. anti glutamate decarboxylase
MS - hay fever - SLE - goodpasture's
DM type 1
IgG
Neisseria bacteremia

27. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Help B cells make antibody - secrete IFN gamma to activate macs
MHC I
Pernicious anemia (to B12 def) - hashimotos thyroiditis
No - peptides only can can be presented on MHC molecules

28. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
Mixed connective tissue disease
DM type 1
IL-12 def

29. Which antibodies activate the classic pathway
C3b
III
IgG - IgM GM makes classic cars
Help B cells make antibody - secrete IFN gamma to activate macs

30. What does a deficiency in C3 lead to...
Help B cells make antibody - secrete IFN gamma to activate macs
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Scleroderma diffuse
Chronic: fibrosis of graft tissue and blood vessels

31. Which is the receptors for EBV?
CD21
Ceilac disase
Chediak Higashi
Paracortex

32. antidesmoglein
Il -4
II
Pemphigus vulgaris
Signal 1 = APC - signal 2 = B7 and CD28

33. HLA- D2

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34. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Steroid - responsive nephrotic syndrome
III
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

35. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Ceilac disase
CD40 and CD40L
Innate

36. What kind of hypersens rxn in anaphylaxis
Signal 1 = APC - signal 2 = B7 and CD28
I
IL-10
Stomach

37. antimicrosomal - antithyroglobulin
Hyper IgM
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
CD40 and CD40L
Hashimotos

38. Which cytokine inhibits Th1 cells
C3b
IL-10
Innate
II

39. What are the cell surface receptors on MACS
Innate
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
APCs - and DR - DP and DQ
Chronic: fibrosis of graft tissue and blood vessels

40. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

41. What are the two signals required for B cells class switching?
Selective Ig def - IgA most common
MS - hay fever - SLE - goodpasture's
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Trypanosomes - programmed rearrangement

42. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

43. HLA- A3
I
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Hemochromocytosis
DiGeorge

44. What do mature B lymphos express on their surface?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG
IgM and IgD

45. Which is the most abundant immunoglobulin in the blood?
Poly/dermato myositis
DM type 1
IgG
Macs - dendritic cell - B cell

46. Anti ds DNA - anti Smith
Fc
Sjorgen's syndrome
Corticomedullary junction
SLE

47. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Innate
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

48. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IgM
Help B cells make antibody - secrete IFN gamma to activate macs
Pernicious anemia (to B12 def) - hashimotos thyroiditis

49. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IL-12 def
Chronic granulomatous disease

50. anti SS A/B or anti Ro/La

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