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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. What are the cytokines involved in macrophage/lymphocyte interaction
IgE
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Common variable immunodeficiency (CVID)
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

2. Which type of hypersens rxn is immune complex mediate
III
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

3. Where do positive and negative selection occur in the thymus?
IgG - IgM GM makes classic cars
RA - DM type 1
Corticomedullary junction
IgM and IgD

4. antimicrosomal - antithyroglobulin
Paracortex
Fab
Leukocyte adhesion deficiency type 1
Hashimotos

5. HLA- A3
Right arm and right half of head
Hemochromocytosis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
SLE

6. antigliadin - antiendomysial
Wegeners granulomatosis
Superficial inguinal pectinate line
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Ceilac disase

7. Defectin in isotype switching
Paracortex
Selective Ig def - IgA most common
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Fc

8. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
B cell localization and proliferation
SCID
Scleroderma diffuse

9. Anti ds DNA - anti Smith
SLE
Hyper IgM
Wegeners granulomatosis
Secondary

10. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IgG - IgM GM makes classic cars
Superficial inguinal pectinate line

11. Defect in DNA repair enzymes
Innate
IgG
Scleroderma diffuse
Ataxia telangectasia

12. Which portion of the antibody determines the isotype
Fc
IFN gamma
IL-12
C5b -9

13. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Hyper IgM
Drug induced lupus

14. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
Ceilac disase
Perforin - granzyme - granulysin
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

15. Which cytokine induces Th1 cell profile in CD4 cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Chronic granulomatous disease
IL-12

16. anti basement membrane
MHC II 4 x 2=8
Il -4
Goodpastures
Chronic granulomatous disease

17. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
IL-4 - 5 - 10
Signal 1 = APC - signal 2 = B7 and CD28
Autoimmune hepatitis

18. What does the Th2 response do?
Regulates the humoral response
C5b -9
Chediak Higashi
PMNs recruited by IL-8 to clear infxns

19. What are the classic example of bacterial antigen variation and the unique mechanims
RA
Chronic: fibrosis of graft tissue and blood vessels
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-12

20. Which antibody mediates type II and type III hypersens rxn
Chronic mucocutaneaous candidiasis
IgG
SCID
Opsonization - neutralization and complement activation

21. Which areas of the body are drained by the axillary lymph node
IgG
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Upper limb and breast
IL-2 and IFN gamma

22. Which cytokines to Th1 cells secrete?
CD21
Graves' dz
IL-4 - 5 - 10
IL-2 and IFN gamma

23. What interferes with viruses?
III
IL-4 - 5 - 10
Innate
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

24. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Leukocyte adhesion deficiency type 1
SLE
C5b -9
No - peptides only can can be presented on MHC molecules

25. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
DM type 1

26. Which is the most abundant immunoglobulin in the blood?
I
IgG
Ataxia telangectasia
RA

27. HLA- DR5
Adaptive
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
III
Pernicious anemia (to B12 def) - hashimotos thyroiditis

28. Anti - IgG (RF)
RA
IgG - IgM GM makes classic cars
Common variable immunodeficiency (CVID)
IL-2 and IFN gamma

29. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Paracortex
SCID

30. How do CD8 cells kill?
All nucleated cells (no RBCs) A - B - C
Perforin - granzyme - granulysin
2
C5b -9

31. c - ANCA
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Wegeners granulomatosis
Il -4
IL-4 - 5 - 10

32. Which antibody mediates a type Hypersens rxn?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IgE
Adaptive

33. Which parts of the antibody to heavy chain contribute?
Fc and Fab
Hyper IgE syndrome (Job's)
CD40 and CD40L
Opsonization - neutralization and complement activation

34. Which type of hypersens rxn is serum sickness?
III
IL-12
Fab
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

35. HLA- D2

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36. What are the three APCs
Steroid - responsive nephrotic syndrome
IgM and IgD
Macs - dendritic cell - B cell
Superficial inguinal pectinate line

37. ANA
Wegeners granulomatosis
Sjorgen's syndrome
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
SLE - nonspecific

38. p - ANCA
Hyper IgM
IL-12 - IFN- beta. IFN- alpha
Poly/dermato myositis
Other vasculitidies

39. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
SLE
Goodpastures
Adaptive

40. anti SS A/B or anti Ro/La

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41. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
IL-4 - 5 - 10
Poly/dermato myositis
Macs - dendritic cell - B cell

42. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Macs - dendritic cell - B cell
Major shift minor drift
2

43. anti glutamate decarboxylase
Drug induced lupus
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
DM type 1
Hashimotos

44. AR - defect in microtubule fxn with decreased phagocytosis
Secondary
Chediak Higashi
Hemochromocytosis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

45. Antimitochondrial
C5b -9
RA - DM type 1
Primary biliary cirrohosis
Superficial inguinal pectinate line

46. Which complement protein opsonizes bacteria?
IV
Bruton's agamma
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
C3b

47. thwat does the Right lymphatic duct drain?
Chediak Higashi
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Right arm and right half of head
CD40 and CD40L

48. What is the arthus rxn?
CD56
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IgM

49. What is the difference in antigenic variation in viruses
Scleroderma CREST
III
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Major shift minor drift

50. Which parasites exhibit antigenic variation
DiGeorge
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Trypanosomes - programmed rearrangement
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8