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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Defect in LFA-1 integrin CD18 protein on phagocytes
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Leukocyte adhesion deficiency type 1
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

2. T cell dysfunction
Chronic mucocutaneaous candidiasis
CD8 cells
C3b
Other vasculitidies

3. Which parasites exhibit antigenic variation
DiGeorge
Trypanosomes - programmed rearrangement
Innate
Hyper IgE syndrome (Job's)

4. thwat does the Right lymphatic duct drain?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Right arm and right half of head
III
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

5. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IgG - IgM GM makes classic cars
MHC I
CD56

6. Cell surface receptors on B cels
Fc and Fab
IL-12
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Chediak Higashi

7. Which type of hypersens rxn is serum sickness?
III
Primary biliary cirrohosis
Hemochromocytosis
Adaptive

8. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Innate
Corticomedullary junction
Hyper IgM

9. Which bacteria secrete superantigen
IL-10
Chronic mucocutaneaous candidiasis
S. aureus and S. pyogenes
Selective Ig def - IgA most common

10. HLA- B27

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11. What are the two signals in helper T activation?
Neisseria bacteremia
Signal 1 = APC - signal 2 = B7 and CD28
IgM and IgD
Trypanosomes - programmed rearrangement

12. Defect in CD40L on helper T
IgG - IgM GM makes classic cars
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Hyper IgM
Steroid - responsive nephrotic syndrome

13. Transplant rejection: preformed host antibody mediated
Secondary
No - peptides only can can be presented on MHC molecules
Hyperacute : occlusion - ischemia - necrosis
Primary biliary cirrohosis

14. Which antibody (IgM or IgG) crosses the placenta?
IgG
Scleroderma CREST
Pernicious anemia (to B12 def) - hashimotos thyroiditis
SLE - nonspecific

15. transplant rejection: T cell and antibody mediated vasular damage
Graves' dz
Chronic: fibrosis of graft tissue and blood vessels
Adaptive
PMNs recruited by IL-8 to clear infxns

16. antimicrosomal - antithyroglobulin
Opsonization - neutralization and complement activation
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Hemochromocytosis
Hashimotos

17. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
Chronic granulomatous disease
DM type 1
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

18. antismooth muscle
IL-4 - 5 - 10
Adaptive
Upper limb and breast
Autoimmune hepatitis

19. HLA- A3
Innate
Hemochromocytosis
Adaptive
Corticomedullary junction

20. What do superantigens do?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
RA

21. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Secondary
Chronic granulomatous disease
No - peptides only can can be presented on MHC molecules
CD21

22. Which parts of the antibody to light chain contribute
Fab
III
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Autoimmune hepatitis

23. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Pemphigus vulgaris
Chronic granulomatous disease
CD8 cells
Innate

24. Anticentromere
Secondary
Scleroderma CREST
DM type 1
Pernicious anemia (to B12 def) - hashimotos thyroiditis

25. HLA- DR4
DM type 1
CD40 and CD40L
RA - DM type 1
Steroid - responsive nephrotic syndrome

26. Where is MHC II expressed and and which HLA molecules codes for it
Chediak Higashi
APCs - and DR - DP and DQ
Il -4
Chronic mucocutaneaous candidiasis

27. Which areas of the body are drained by the axillary lymph node
II
IL-2 and IFN gamma
S. aureus and S. pyogenes
Upper limb and breast

28. What are the 3 funxtions of antibodies?
IgG
Opsonization - neutralization and complement activation
III
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

29. What does a deficiency in C5- C8 lead to?
MHC II 4 x 2=8
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Neisseria bacteremia
III

30. Which type of hypersens rxn is immune complex mediate
Pernicious anemia (to B12 def) - hashimotos thyroiditis
III
Bruton's agamma
Corticomedullary junction

31. Which cytokines to Th1 cells secrete?
Secondary
IL-2 and IFN gamma
Everything else - not right arm and right half of head
Mesenchyme

32. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Prevents attachment of bacteria and viruses to mucous membranes
Adaptive
III
IV

33. Deficiency in DAF
Fc and Fab
Stomach
Macs - dendritic cell - B cell
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

34. What does a deficiency in C3 lead to...
Chediak Higashi
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IgM and IgD
2

35. anti U1 RNP
Major shift minor drift
Stomach
Hereditary angioedema
Mixed connective tissue disease

36. Which kind of immunity is germline encoded?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Innate
Bruton's agamma
IgG

37. AR - defect in microtubule fxn with decreased phagocytosis
SCID
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Chediak Higashi
Trypanosomes - programmed rearrangement

38. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Signal 1 = APC - signal 2 = B7 and CD28
Superficial inguinal pectinate line
Wegeners granulomatosis

39. anti - Jo 1
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-12 def
Poly/dermato myositis
Goodpastures

40. What does the Th2 response do?
CD40 and CD40L
MHC I
Regulates the humoral response
Howell - Jolly bodies - Target cells - thrombocytosis

41. Which cell mediates the type IV hypersens rxn?
2
Corticomedullary junction
CD8 cells
Chediak Higashi

42. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Wegeners granulomatosis
Il -4
Opsonization - neutralization and complement activation

43. which follicles (primary or secondary) have active germinal centers?
Secondary
IgE
Signal 1 = APC - signal 2 = B7 and CD28
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

44. Which MHC complex to CD8 cells bind
IL-10
IL-12 - IFN- beta. IFN- alpha
Regulates the humoral response
MHC I

45. What does a deficiency in C1 esterase inhibitor lead to?
CD56
Hyperacute : occlusion - ischemia - necrosis
Hereditary angioedema
Primary biliary cirrohosis

46. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
II
IgA
IL-12

47. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IL-10
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

48. Which portion of the antibody determines the isotype
Fc
Il -4
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Mesenchyme

49. Defect in DNA repair enzymes
Secondary
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IgA
Ataxia telangectasia

50. Which type of hypersens rxn is antibody mediated?
IgG
Wegeners granulomatosis
II
Major shift minor drift