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Immunology

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1. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
II
IL-12 def
Everything else - not right arm and right half of head

2. Which antibody mediates type II and type III hypersens rxn
IgG
DM type 1
Mesenchyme
Adaptive

3. T cell dysfunction
CD56
Chronic mucocutaneaous candidiasis
No - peptides only can can be presented on MHC molecules
Graves' dz

4. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
RA - DM type 1
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Secondary
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

5. Antimitochondrial
IgG
Other vasculitidies
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Primary biliary cirrohosis

6. What kind of hypersens rxn in anaphylaxis
IgM
Everything else - not right arm and right half of head
I
DM type 1

7. HLA- A3
Hemochromocytosis
CD8 cells
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

8. HLA- B8

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9. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgE
Chronic: fibrosis of graft tissue and blood vessels
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

10. antigliadin - antiendomysial
Ceilac disase
No - peptides only can can be presented on MHC molecules
Upper limb and breast
B cell localization and proliferation

11. Which antibodies activate the classic pathway
Opsonization - neutralization and complement activation
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IgG - IgM GM makes classic cars
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

12. What are the 3 funxtions of antibodies?
Opsonization - neutralization and complement activation
Leukocyte adhesion deficiency type 1
Paracortex
Wegeners granulomatosis

13. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
MHC II 4 x 2=8
Adaptive
CD56

14. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
RA
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Steroid - responsive nephrotic syndrome

15. anti glutamate decarboxylase
PMNs recruited by IL-8 to clear infxns
DM type 1
Innate
Secondary

16. Which kind of immunity is germline encoded?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IL-12 def
Innate

17. decreased Th1 response
IL-12 def
Hashimotos
Paracortex
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

18. X linked recessive defect in BTK no B cell differentiation

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19. What happens in the follicle of the lymph node
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
B cell localization and proliferation
Other vasculitidies
CD56

20. Which type of hypersens rxn is delayed
PMNs recruited by IL-8 to clear infxns
IV
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Howell - Jolly bodies - Target cells - thrombocytosis

21. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Common variable immunodeficiency (CVID)

22. Which type of hypersens rxn is immune complex mediate
III
DM type 1
Wegeners granulomatosis
Graves' dz

23. anti basement membrane
III
Goodpastures
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Chronic: fibrosis of graft tissue and blood vessels

24. Which cell mediates the type IV hypersens rxn?
CD8 cells
Upper limb and breast
Perforin - granzyme - granulysin
IFN gamma

25. What are the cell surface receptors on MACS
Drug induced lupus
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Perforin - granzyme - granulysin
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

26. What are the two signals in helper T activation?
Fc and Fab
MS - hay fever - SLE - goodpasture's
IL-4 - 5 - 10
Signal 1 = APC - signal 2 = B7 and CD28

27. c - ANCA
Scleroderma diffuse
CD40 and CD40L
II
Wegeners granulomatosis

28. Anticentromere
MHC I
Innate
All nucleated cells (no RBCs) A - B - C
Scleroderma CREST

29. Which type of hypersens rxn is antibody mediated?
Perforin - granzyme - granulysin
IL-12
Hyperacute : occlusion - ischemia - necrosis
II

30. HLA- DR7
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Steroid - responsive nephrotic syndrome
DiGeorge
Pemphigus vulgaris

31. Which lymph node drains the anal canal below
2
Superficial inguinal pectinate line
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Perforin - granzyme - granulysin

32. What does the thoracic duct drain?
Paracortex
Everything else - not right arm and right half of head
MHC I
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

33. Which type of hypersens rxn is serum sickness?
DM type 1
III
Signal 1 = APC - signal 2 = B7 and CD28
Fc and Fab

34. Which MHC complex to CD8 cells bind
MHC I
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Hemochromocytosis
IFN gamma

35. Which immunoglobulin is a pentamer
IgM
Paracortex
DM type 1
Chronic: fibrosis of graft tissue and blood vessels

36. Which cytokine induces Th1 cell profile in CD4 cells
DiGeorge
IL-12
IL-2 and IFN gamma
Leukocyte adhesion deficiency type 1

37. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
Chronic mucocutaneaous candidiasis
Hyperacute : occlusion - ischemia - necrosis
Selective Ig def - IgA most common

38. AR - defect in microtubule fxn with decreased phagocytosis
Graves' dz
Perforin - granzyme - granulysin
Chediak Higashi
IL-10

39. What inhibits Th2 cells
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Scleroderma diffuse
IFN gamma
IL-12

40. Anti Scl 70 (DNA topo I
RA
Macs - dendritic cell - B cell
Paracortex
Scleroderma diffuse

41. Which complement proteins make up the MAC
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Fc and Fab
Scleroderma CREST
C5b -9

42. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
MHC I
III
Pernicious anemia (to B12 def) - hashimotos thyroiditis

43. What is the main function of IgA
Hyper IgE syndrome (Job's)
Perforin - granzyme - granulysin
IL-2 and IFN gamma
Prevents attachment of bacteria and viruses to mucous membranes

44. transplant rejection: T cell and antibody mediated vasular damage
Scleroderma diffuse
Trypanosomes - programmed rearrangement
Chronic: fibrosis of graft tissue and blood vessels
C3b

45. Which parts of the antibody to heavy chain contribute?
Fc and Fab
SCID
RA
Common variable immunodeficiency (CVID)

46. What cytokines to Th2 cells secrete?
Adaptive
IL-4 - 5 - 10
All nucleated cells (no RBCs) A - B - C
SLE - nonspecific

47. What are the three APCs
Perforin - granzyme - granulysin
Macs - dendritic cell - B cell
APCs - and DR - DP and DQ
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

48. Which parts of the antibody to light chain contribute
Drug induced lupus
Fab
CD14
Scleroderma diffuse

49. antimicrosomal - antithyroglobulin
B cell localization and proliferation
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Hashimotos
All nucleated cells (no RBCs) A - B - C

50. Where do positive and negative selection occur in the thymus?
IgM and IgD
Corticomedullary junction
Autoimmune hepatitis
Trypanosomes - programmed rearrangement

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