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Immunology

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Answer 50 questions in 15 minutes.
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1. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Ataxia telangectasia
Pemphigus vulgaris

2. What are the three APCs
IL-10
Macs - dendritic cell - B cell
MS - hay fever - SLE - goodpasture's
Help B cells make antibody - secrete IFN gamma to activate macs

3. Anti ds DNA - anti Smith
Il -4
IL-4 - 5 - 10
MHC II 4 x 2=8
SLE

4. What does a deficiency in C5- C8 lead to?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Neisseria bacteremia
Trypanosomes - programmed rearrangement
Major shift minor drift

5. Cell surface receptors on B cels
CD40 and CD40L
Bruton's agamma
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
MHC II 4 x 2=8

6. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Wegeners granulomatosis
Chronic granulomatous disease
CD56
Goodpastures

7. Where is MHC I expressed - and which HLA molecules code for it
Trypanosomes - programmed rearrangement
Ceilac disase
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
All nucleated cells (no RBCs) A - B - C

8. What kind of hypersens rxn in anaphylaxis
Mixed connective tissue disease
CD14
Right arm and right half of head
I

9. What does HOT- T- Bone stEAk stand for?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Goodpastures
IL-12
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

10. What does the Th2 response do?
Fc
DiGeorge
Regulates the humoral response
Trypanosomes - programmed rearrangement

11. What does a deficiency in C1 esterase inhibitor lead to?
MHC I
CD14
Hereditary angioedema
Steroid - responsive nephrotic syndrome

12. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
Hyperacute : occlusion - ischemia - necrosis
CD8 cells
C3b

13. Which MHC complex to CD4 cells bind
Chronic: fibrosis of graft tissue and blood vessels
Hyperacute : occlusion - ischemia - necrosis
S. aureus and S. pyogenes
MHC II 4 x 2=8

14. What do mature B lymphos express on their surface?
IgM and IgD
IgG - IgM GM makes classic cars
Primary biliary cirrohosis
Superficial inguinal pectinate line

15. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
Scleroderma diffuse
Everything else - not right arm and right half of head
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

16. Where is MHC II expressed and and which HLA molecules codes for it
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
I
APCs - and DR - DP and DQ
IgA

17. which areas of the body are drained by the celiac lymph node?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Drug induced lupus
Neisseria bacteremia
Stomach

18. Anticentromere
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Chediak Higashi
Sjorgen's syndrome
Scleroderma CREST

19. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Macs - dendritic cell - B cell
Selective Ig def - IgA most common
Drug induced lupus

20. What does clean up on Aisle 8 stand for?
Corticomedullary junction
Scleroderma diffuse
PMNs recruited by IL-8 to clear infxns
CD14

21. What cytokines to Th2 cells secrete?
Chronic granulomatous disease
IL-4 - 5 - 10
Major shift minor drift
No - peptides only can can be presented on MHC molecules

22. HLA- B8

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23. anti basement membrane
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Goodpastures
Fc and Fab
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

24. How do CD8 cells kill?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Perforin - granzyme - granulysin
IL-12 def
Signal 1 = APC - signal 2 = B7 and CD28

25. antigliadin - antiendomysial
Chronic mucocutaneaous candidiasis
IL-12 - IFN- beta. IFN- alpha
Major shift minor drift
Ceilac disase

26. Th cells don't produce IFN gamma - no PMN response

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27. What is the unique cell marker for NK cells
Paracortex
Selective Ig def - IgA most common
CD56
MHC I

28. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Hereditary angioedema
Macs - dendritic cell - B cell
MHC I

29. Which antibody mediates type II and type III hypersens rxn
Scleroderma CREST
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IgG
Mixed connective tissue disease

30. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Hyperacute : occlusion - ischemia - necrosis

31. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Stomach
Steroid - responsive nephrotic syndrome
IL-12 - IFN- beta. IFN- alpha

32. ANA
SLE - nonspecific
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Perforin - granzyme - granulysin
Mixed connective tissue disease

33. Which type of hypersens rxn is delayed
Stomach
IV
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgM and IgD

34. antidesmoglein
Scleroderma diffuse
Pemphigus vulgaris
Right arm and right half of head
Macs - dendritic cell - B cell

35. Which parts of the antibody to heavy chain contribute?
Fc and Fab
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
C5b -9
IgG

36. Which complement protein opsonizes bacteria?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Stomach
C3b
SCID

37. Which is the receptors for EBV?
Fc and Fab
CD21
IFN gamma
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

38. antismooth muscle
Hereditary angioedema
Secondary
MS - hay fever - SLE - goodpasture's
Autoimmune hepatitis

39. Antimitochondrial
MS - hay fever - SLE - goodpasture's
Primary biliary cirrohosis
Innate
IL-2 and IFN gamma

40. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Il -4
Chronic granulomatous disease
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
DiGeorge

41. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
I
Ataxia telangectasia
Steroid - responsive nephrotic syndrome

42. Which infections require administering passive immunity?
Il -4
Wegeners granulomatosis
No - peptides only can can be presented on MHC molecules
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

43. Cell surface receptors on T cells
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Mesenchyme
MHC II 4 x 2=8
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

44. HLA- DR5
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Macs - dendritic cell - B cell
Leukocyte adhesion deficiency type 1

45. Which type of hypersens rxn is the arthus rxn
Right arm and right half of head
Fc and Fab
Mature t cells - epithelial reticular cells - Hassalls corpuscles
III

46. Which is the most abundant immunoglobulin in the blood?
IgG
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
SLE
DiGeorge

47. Which cytokines to Th1 cells secrete?
Opsonization - neutralization and complement activation
All nucleated cells (no RBCs) A - B - C
IgM
IL-2 and IFN gamma

48. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
IL-4 - 5 - 10
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
CD56

49. HLA- DR7
Wegeners granulomatosis
Other vasculitidies
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Steroid - responsive nephrotic syndrome

50. Antihistone
Chronic mucocutaneaous candidiasis
SLE
Fc
Drug induced lupus

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