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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Corticomedullary junction
RA - DM type 1
C5b -9

2. which areas of the body are drained by the celiac lymph node?
S. aureus and S. pyogenes
Superficial inguinal pectinate line
Mixed connective tissue disease
Stomach

3. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Chronic granulomatous disease
IgA
Superficial inguinal pectinate line
No - peptides only can can be presented on MHC molecules

4. Anti Scl 70 (DNA topo I
Graves' dz
Sjorgen's syndrome
IgM and IgD
Scleroderma diffuse

5. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-12 def
Pernicious anemia (to B12 def) - hashimotos thyroiditis
CD21

6. Cell surface receptors on T cells
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
APCs - and DR - DP and DQ
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

7. Which lymph node drains the anal canal below
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgG - IgM GM makes classic cars
Superficial inguinal pectinate line
No - peptides only can can be presented on MHC molecules

8. What happens in the follicle of the lymph node
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
B cell localization and proliferation
Goodpastures

9. What do superantigens do?
IgG - IgM GM makes classic cars
PMNs recruited by IL-8 to clear infxns
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

10. Defect in LFA-1 integrin CD18 protein on phagocytes
CD14
Leukocyte adhesion deficiency type 1
Chronic mucocutaneaous candidiasis
No - peptides only can can be presented on MHC molecules

11. What are the three APCs
Everything else - not right arm and right half of head
Macs - dendritic cell - B cell
C3b
IL-2 and IFN gamma

12. ANA
SLE - nonspecific
RA
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Common variable immunodeficiency (CVID)

13. Where do positive and negative selection occur in the thymus?
Hashimotos
IgM
Corticomedullary junction
Fc

14. Which complement protein opsonizes bacteria?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Ataxia telangectasia
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
C3b

15. X linked recessive defect in BTK no B cell differentiation

16. What are the two signals required for B cells class switching?
Hemochromocytosis
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Ceilac disase

17. antidesmoglein
Primary biliary cirrohosis
Hereditary angioedema
Fab
Pemphigus vulgaris

18. Anti - IgG (RF)
Help B cells make antibody - secrete IFN gamma to activate macs
S. aureus and S. pyogenes
Scleroderma diffuse
RA

19. What does the thoracic duct drain?
Il -4
IgG
Poly/dermato myositis
Everything else - not right arm and right half of head

20. Where is MHC I expressed - and which HLA molecules code for it
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IL-12
Common variable immunodeficiency (CVID)
All nucleated cells (no RBCs) A - B - C

21. Which cytokines to Th1 cells secrete?
Scleroderma diffuse
IL-2 and IFN gamma
Hyperacute : occlusion - ischemia - necrosis
IgG

22. T cell dysfunction
Chronic mucocutaneaous candidiasis
IL-12 def
RA
SLE

23. What is the clinical picture for serum sickness?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Major shift minor drift
Hereditary angioedema

24. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
MHC II 4 x 2=8
Bruton's agamma
DiGeorge

25. Deficiency in DAF
CD40 and CD40L
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Leukocyte adhesion deficiency type 1

26. Which MHC complex to CD4 cells bind
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
MHC II 4 x 2=8
Sjorgen's syndrome

27. Which antibody mediates a type Hypersens rxn?
IgE
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Fc
CD56

28. What is the arthus rxn?
IL-12
IL-10
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Regulates the humoral response

29. Defectin in isotype switching
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IV
Selective Ig def - IgA most common
C5b -9

30. thwat does the Right lymphatic duct drain?
2
Help B cells make antibody - secrete IFN gamma to activate macs
Right arm and right half of head
Scleroderma diffuse

31. Which type of hypersens rxn is the arthus rxn
SLE
2
III
IgM

32. Anticentromere
Scleroderma CREST
Common variable immunodeficiency (CVID)
IFN gamma
Hashimotos

33. anti glutamate decarboxylase
IgM
Stomach
Pemphigus vulgaris
DM type 1

34. Where is MHC II expressed and and which HLA molecules codes for it
CD56
Mixed connective tissue disease
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
APCs - and DR - DP and DQ

35. What does HOT- T- Bone stEAk stand for?
IV
Prevents attachment of bacteria and viruses to mucous membranes
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
CD21

36. Which portion of the antibody determines the isotype
Innate
Trypanosomes - programmed rearrangement
Fc
Fc and Fab

37. Defect in CD40L on helper T
IgM
IL-10
Wegeners granulomatosis
Hyper IgM

38. Which infections require administering passive immunity?
Everything else - not right arm and right half of head
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgG
Help B cells make antibody - secrete IFN gamma to activate macs

39. What interferes with viruses?
Fab
Graves' dz
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

40. anti U1 RNP
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Poly/dermato myositis
IgG - IgM GM makes classic cars
Mixed connective tissue disease

41. Which area of the lymph node englarges in an extreme immune response
Paracortex
Hemochromocytosis
IL-12 def
Opsonization - neutralization and complement activation

42. Which parasites exhibit antigenic variation
IL-12
Corticomedullary junction
I
Trypanosomes - programmed rearrangement

43. Cell surface receptors on B cels
Regulates the humoral response
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
III
Right arm and right half of head

44. Which complement proteins make up the MAC
Scleroderma diffuse
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Signal 1 = APC - signal 2 = B7 and CD28
C5b -9

45. Which antibodies activate the classic pathway
Hyper IgM
Poly/dermato myositis
IgG - IgM GM makes classic cars
Paracortex

46. Antimitochondrial
RA
Primary biliary cirrohosis
S. aureus and S. pyogenes
Mature t cells - epithelial reticular cells - Hassalls corpuscles

47. Which type of hypersens rxn is serum sickness?
Scleroderma diffuse
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Trypanosomes - programmed rearrangement
III

48. Defect in B cell maturation
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Common variable immunodeficiency (CVID)
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Graves' dz

49. HLA- DR3
Everything else - not right arm and right half of head
S. aureus and S. pyogenes
DM type 1
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

50. What inhibits Th2 cells
I
MHC I
IFN gamma
Mesenchyme