Test your basic knowledge |

Immunology

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. antimicrosomal - antithyroglobulin
Chronic: fibrosis of graft tissue and blood vessels
IgA
Hashimotos
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

2. What does the Th2 response do?
Regulates the humoral response
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Macs - dendritic cell - B cell
S. aureus and S. pyogenes

3. Which complement protein opsonizes bacteria?
S. aureus and S. pyogenes
Scleroderma diffuse
C3b
Howell - Jolly bodies - Target cells - thrombocytosis

4. Where is MHC I expressed - and which HLA molecules code for it
Common variable immunodeficiency (CVID)
All nucleated cells (no RBCs) A - B - C
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IL-2 and IFN gamma

5. X linked recessive defect in BTK no B cell differentiation

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

6. What is the role of CD4 cels
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
CD40 and CD40L
IL-2 and IFN gamma
Help B cells make antibody - secrete IFN gamma to activate macs

7. anti SS A/B or anti Ro/La

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

8. What happens in the follicle of the lymph node
Neisseria bacteremia
IgG
I
B cell localization and proliferation

9. Which antibody mediates type II and type III hypersens rxn
Opsonization - neutralization and complement activation
IgG
CD21
Graves' dz

10. Anti ds DNA - anti Smith
SLE
Bruton's agamma
IgG
IgA

11. What is the unique cell marker for NK cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
All nucleated cells (no RBCs) A - B - C
Macs - dendritic cell - B cell
CD56

12. p - ANCA
Perforin - granzyme - granulysin
CD21
Other vasculitidies
II

13. Which type of hypersens rxn is delayed
2
IV
MHC II 4 x 2=8
Stomach

14. How do NK cells kill?
RA
III
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

15. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
No - peptides only can can be presented on MHC molecules
IgG - IgM GM makes classic cars
IL-12 - IFN- beta. IFN- alpha

16. Which is the receptors for EBV?
IgM and IgD
CD21
Everything else - not right arm and right half of head
I

17. Which MHC complex to CD4 cells bind
MHC II 4 x 2=8
IL-12
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Ataxia telangectasia

18. What is the clinical picture for serum sickness?
Primary biliary cirrohosis
Chronic: fibrosis of graft tissue and blood vessels
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Bruton's agamma

19. What embryologic tissue are lymphcytes derived from
IV
SLE
CD40 and CD40L
Mesenchyme

20. HLA- DR5
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Regulates the humoral response

21. decreased Th1 response
IL-12 def
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Pernicious anemia (to B12 def) - hashimotos thyroiditis

22. What kind of bacteria do macrophages remove from the spleen?
Hashimotos
IV
Scleroderma CREST
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

23. HLA- DR4
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
RA - DM type 1
Regulates the humoral response

24. anti - Jo 1
IgG
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Fc
Poly/dermato myositis

25. Which areas of the body are drained by the axillary lymph node
Scleroderma diffuse
Ceilac disase
IL-4 - 5 - 10
Upper limb and breast

26. Which MHC complex to CD8 cells bind
Major shift minor drift
Il -4
MHC I
I

27. Which antibody mediates a type Hypersens rxn?
III
IgE
III
DiGeorge

28. Which parasites exhibit antigenic variation
Superficial inguinal pectinate line
Trypanosomes - programmed rearrangement
Hyperacute : occlusion - ischemia - necrosis
Macs - dendritic cell - B cell

29. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Neisseria bacteremia
IL-12 def
IgM
IgA

30. antidesmoglein
Il -4
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Pemphigus vulgaris
DM type 1

31. antismooth muscle
RA
Pemphigus vulgaris
Signal 1 = APC - signal 2 = B7 and CD28
Autoimmune hepatitis

32. Which cytokine induces Th1 cell profile in CD4 cells
2
CD40 and CD40L
IgM and IgD
IL-12

33. HLA- DR7
Autoimmune hepatitis
Primary biliary cirrohosis
Corticomedullary junction
Steroid - responsive nephrotic syndrome

34. What are the three things you find post splenectomy
Howell - Jolly bodies - Target cells - thrombocytosis
IgG
DM type 1
Hyper IgE syndrome (Job's)

35. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
RA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Hyper IgM

36. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
RA - DM type 1
IL-12

37. Which B T cell interaction allows for immunologic memory and class switching?
Upper limb and breast
III
CD40 and CD40L
Scleroderma CREST

38. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Bruton's agamma
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Adaptive

39. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Ataxia telangectasia
SCID
S. aureus and S. pyogenes
Upper limb and breast

40. Which type of hypersens rxn is the arthus rxn
APCs - and DR - DP and DQ
III
DM type 1
Pernicious anemia (to B12 def) - hashimotos thyroiditis

41. AR - defect in microtubule fxn with decreased phagocytosis
C3b
Trypanosomes - programmed rearrangement
Fab
Chediak Higashi

42. Which cytokine inhibits Th1 cells
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-10
Il -4

43. Transplant rejection: preformed host antibody mediated
IL-12 - IFN- beta. IFN- alpha
II
Hyperacute : occlusion - ischemia - necrosis
Drug induced lupus

44. Which bacteria secrete superantigen
Selective Ig def - IgA most common
I
S. aureus and S. pyogenes
Mesenchyme

45. Which antibodies activate the classic pathway
Hashimotos
IgG - IgM GM makes classic cars
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Adaptive

46. HLA- B8

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

47. What are the 3 funxtions of antibodies?
Fab
Opsonization - neutralization and complement activation
Ceilac disase
IgG

48. Antimitochondrial
B cell localization and proliferation
IL-2 and IFN gamma
Primary biliary cirrohosis
IgG

49. What are the three APCs
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Macs - dendritic cell - B cell
IgG
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

50. Anti - IgG (RF)
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
RA
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Bruton's agamma