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Test your basic knowledge |
Immunology
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the 3 funxtions of antibodies?
Opsonization - neutralization and complement activation
Chronic granulomatous disease
DM type 1
SCID
2. Which cytokine inhibits Th1 cells
MHC I
DM type 1
IL-10
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
3. Which MHC complex to CD8 cells bind
2
Adaptive
Primary biliary cirrohosis
MHC I
4. What do mature B lymphos express on their surface?
I
IgM and IgD
Hereditary angioedema
Corticomedullary junction
5. which follicles (primary or secondary) have active germinal centers?
IgG - IgM GM makes classic cars
II
Wegeners granulomatosis
Secondary
6. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
CD40 and CD40L
Hyper IgE syndrome (Job's)
SLE - nonspecific
7. HLA- A3
III
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Howell - Jolly bodies - Target cells - thrombocytosis
Hemochromocytosis
8. anti SS A/B or anti Ro/La
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9. Cell surface receptors on T cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Opsonization - neutralization and complement activation
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
10. What is the unique cell marker for NK cells
PMNs recruited by IL-8 to clear infxns
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Scleroderma CREST
CD56
11. HLA- DR5
Sjorgen's syndrome
Graves' dz
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
12. Which cytokine induces Th2 cell profile in CD4 cells
Adaptive
SLE - nonspecific
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Il -4
13. Which type of hypersens rxn is serum sickness?
IgM
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
III
SCID
14. anti - Jo 1
Poly/dermato myositis
Trypanosomes - programmed rearrangement
DiGeorge
Opsonization - neutralization and complement activation
15. What does a deficiency in C3 lead to...
SCID
MS - hay fever - SLE - goodpasture's
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IgG
16. AR - defect in microtubule fxn with decreased phagocytosis
IgE
MS - hay fever - SLE - goodpasture's
II
Chediak Higashi
17. Which type of hypersens rxn is immune complex mediate
MS - hay fever - SLE - goodpasture's
III
IL-12 def
MHC I
18. Th cells don't produce IFN gamma - no PMN response
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19. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
RA
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Mesenchyme
20. Defect in DNA repair enzymes
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Ataxia telangectasia
III
Chronic granulomatous disease
21. Defect in CD40L on helper T
Hyper IgM
Signal 1 = APC - signal 2 = B7 and CD28
Major shift minor drift
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
22. What do you find in the medulla of the thymus?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Secondary
IV
23. Which complement proteins make up the MAC
C5b -9
IL-4 - 5 - 10
Drug induced lupus
Signal 1 = APC - signal 2 = B7 and CD28
24. Which cytokines to Th1 cells secrete?
CD56
IL-2 and IFN gamma
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Fab
25. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
No - peptides only can can be presented on MHC molecules
Hemochromocytosis
Il -4
26. How many signals are required for T cell activation or B cell class switching?
RA - DM type 1
2
Goodpastures
Bruton's agamma
27. Which immunoglobulin is a pentamer
Trypanosomes - programmed rearrangement
IgM
Macs - dendritic cell - B cell
Chediak Higashi
28. antigliadin - antiendomysial
Fab
Ceilac disase
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
CD8 cells
29. HLA- D2
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30. What is the difference in antigenic variation in viruses
S. aureus and S. pyogenes
Il -4
Major shift minor drift
Scleroderma diffuse
31. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
APCs - and DR - DP and DQ
DiGeorge
Drug induced lupus
Chediak Higashi
32. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
33. Which is the receptors for EBV?
CD21
Chronic: fibrosis of graft tissue and blood vessels
Upper limb and breast
IL-4 - 5 - 10
34. What does clean up on Aisle 8 stand for?
CD21
PMNs recruited by IL-8 to clear infxns
Adaptive
Steroid - responsive nephrotic syndrome
35. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Superficial inguinal pectinate line
IgA
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Everything else - not right arm and right half of head
36. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Hyper IgE syndrome (Job's)
Poly/dermato myositis
Hyper IgM
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
37. What are the 4 T's of type IV hypersense
Hashimotos
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
SLE - nonspecific
Innate
38. Cell surface receptors on B cels
SCID
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
III
I
39. Which type of hypersens rxn is delayed
SLE
Hashimotos
Steroid - responsive nephrotic syndrome
IV
40. antismooth muscle
Chediak Higashi
Goodpastures
Autoimmune hepatitis
IgA
41. Anti ds DNA - anti Smith
SLE
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Scleroderma CREST
DM type 1
42. Where is MHC I expressed - and which HLA molecules code for it
Trypanosomes - programmed rearrangement
Hyperacute : occlusion - ischemia - necrosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
All nucleated cells (no RBCs) A - B - C
43. What kind of bacteria do macrophages remove from the spleen?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
SCID
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
III
44. Which B T cell interaction allows for immunologic memory and class switching?
Superficial inguinal pectinate line
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Help B cells make antibody - secrete IFN gamma to activate macs
CD40 and CD40L
45. Which bacteria secrete superantigen
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Primary biliary cirrohosis
S. aureus and S. pyogenes
46. antidesmoglein
Everything else - not right arm and right half of head
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Pemphigus vulgaris
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
47. What interferes with viruses?
Prevents attachment of bacteria and viruses to mucous membranes
I
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Goodpastures
48. What are the cell surface receptors on MACS
Steroid - responsive nephrotic syndrome
II
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Signal 1 = APC - signal 2 = B7 and CD28
49. Which parts of the antibody to heavy chain contribute?
RA - DM type 1
IL-4 - 5 - 10
Fc and Fab
Fc
50. T cell dysfunction
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Chronic mucocutaneaous candidiasis
IL-2 and IFN gamma
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn