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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What does a deficiency in C3 lead to...
MHC II 4 x 2=8
Regulates the humoral response
Il -4
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

2. Anti ds DNA - anti Smith
SLE
SCID
Autoimmune hepatitis
III

3. Defect in CD40L on helper T
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
MS - hay fever - SLE - goodpasture's
Hyper IgM
Stomach

4. HLA- B8

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5. decreased Th1 response
CD56
IL-12 def
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Adaptive

6. Which parts of the antibody to light chain contribute
MHC II 4 x 2=8
Fab
Paracortex
CD40 and CD40L

7. antidesmoglein
MHC II 4 x 2=8
Drug induced lupus
Perforin - granzyme - granulysin
Pemphigus vulgaris

8. What does the Th2 response do?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
All nucleated cells (no RBCs) A - B - C
Regulates the humoral response
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

9. Which complement proteins make up the MAC
C5b -9
Autoimmune hepatitis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IgG

10. What kind of hypersens rxn in anaphylaxis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
I
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

11. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
IgA
DiGeorge
CD14
DM type 1

12. Anti Scl 70 (DNA topo I
MHC I
Scleroderma diffuse
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
CD40 and CD40L

13. What is the difference in antigenic variation in viruses
S. aureus and S. pyogenes
CD56
Major shift minor drift
RA

14. What kind of bacteria do macrophages remove from the spleen?
IgM and IgD
Goodpastures
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Ceilac disase

15. HLA- A3
Drug induced lupus
Hemochromocytosis
C3b
Fc and Fab

16. What is the main function of IgA
IL-10
IgM and IgD
Prevents attachment of bacteria and viruses to mucous membranes
Scleroderma CREST

17. What cytokines to Th2 cells secrete?
Drug induced lupus
Superficial inguinal pectinate line
C3b
IL-4 - 5 - 10

18. antimicrosomal - antithyroglobulin
Wegeners granulomatosis
Paracortex
Hashimotos
IL-12 def

19. What are the 4 T's of type IV hypersense
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
DiGeorge
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
I

20. Defect in B cell maturation
Common variable immunodeficiency (CVID)
SLE
MHC II 4 x 2=8
Hemochromocytosis

21. Which parts of the antibody to heavy chain contribute?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Fc and Fab
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
S. aureus and S. pyogenes

22. thwat does the Right lymphatic duct drain?
IgG
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Trypanosomes - programmed rearrangement
Right arm and right half of head

23. What does the thoracic duct drain?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Everything else - not right arm and right half of head
IL-4 - 5 - 10

24. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Stomach
Ataxia telangectasia
CD14

25. HLA- DR3
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Trypanosomes - programmed rearrangement
DM type 1
MS - hay fever - SLE - goodpasture's

26. Which cell mediates the type IV hypersens rxn?
CD8 cells
Signal 1 = APC - signal 2 = B7 and CD28
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Help B cells make antibody - secrete IFN gamma to activate macs

27. transplant rejection: T cell and antibody mediated vasular damage
Help B cells make antibody - secrete IFN gamma to activate macs
Chronic: fibrosis of graft tissue and blood vessels
S. aureus and S. pyogenes
Chediak Higashi

28. anti U1 RNP
Secondary
IL-12 - IFN- beta. IFN- alpha
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Mixed connective tissue disease

29. Which is the receptors for EBV?
Hyper IgM
CD21
Stomach
Chronic granulomatous disease

30. which follicles (primary or secondary) have active germinal centers?
C3b
Chronic granulomatous disease
Secondary
Mixed connective tissue disease

31. Defectin in isotype switching
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Selective Ig def - IgA most common
IL-4 - 5 - 10
SLE - nonspecific

32. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
All nucleated cells (no RBCs) A - B - C
Sjorgen's syndrome
CD14

33. HLA- DR5
CD56
Chronic granulomatous disease
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

34. How do CD8 cells kill?
Perforin - granzyme - granulysin
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
DM type 1
III

35. antismooth muscle
Autoimmune hepatitis
Hereditary angioedema
CD14
II

36. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
IgM and IgD
Chronic granulomatous disease
Goodpastures
Pernicious anemia (to B12 def) - hashimotos thyroiditis

37. Defect in DNA repair enzymes
IgM and IgD
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Everything else - not right arm and right half of head
Ataxia telangectasia

38. Transplant rejection: preformed host antibody mediated
B cell localization and proliferation
C5b -9
Il -4
Hyperacute : occlusion - ischemia - necrosis

39. What happens in the follicle of the lymph node
CD56
B cell localization and proliferation
Hereditary angioedema
Secondary

40. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
III
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

41. What embryologic tissue are lymphcytes derived from
Mesenchyme
Fab
C5b -9
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

42. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Trypanosomes - programmed rearrangement
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Steroid - responsive nephrotic syndrome

43. Which type of hypersens rxn is antibody mediated?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Hashimotos
II
III

44. Which cytokine inhibits Th1 cells
Scleroderma CREST
Chediak Higashi
IL-10
RA - DM type 1

45. What are the 3 funxtions of antibodies?
III
Opsonization - neutralization and complement activation
Selective Ig def - IgA most common
Other vasculitidies

46. What are the cytokines involved in macrophage/lymphocyte interaction
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Pemphigus vulgaris
Corticomedullary junction

47. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Right arm and right half of head
Chronic granulomatous disease
IL-10

48. Which antibody (IgM or IgG) crosses the placenta?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Regulates the humoral response
APCs - and DR - DP and DQ
IgG

49. What are the two signals in cytotoxic T cells activation?
Neisseria bacteremia
Hyper IgE syndrome (Job's)
III
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

50. Cell surface receptors on B cels
MHC I
Chronic mucocutaneaous candidiasis
IgE
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7