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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Scleroderma CREST
Regulates the humoral response
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

2. What cytokines to Th2 cells secrete?
IL-4 - 5 - 10
I
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Poly/dermato myositis

3. which areas of the body are drained by the celiac lymph node?
Stomach
Opsonization - neutralization and complement activation
Signal 1 = APC - signal 2 = B7 and CD28
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

4. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
III
Chronic granulomatous disease
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

5. antigliadin - antiendomysial
Ceilac disase
Stomach
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
No - peptides only can can be presented on MHC molecules

6. What are the classic example of bacterial antigen variation and the unique mechanims
CD56
Hashimotos
B cell localization and proliferation
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

7. Which parasites exhibit antigenic variation
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
CD14
Trypanosomes - programmed rearrangement
IL-12

8. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
DM type 1
CD40 and CD40L
IgA
IV

9. Anti ds DNA - anti Smith
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
SLE
IL-2 and IFN gamma
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

10. Which is the receptors for EBV?
IgG
DiGeorge
CD21
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

11. What embryologic tissue are lymphcytes derived from
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Mesenchyme
Il -4
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

12. HLA- B8

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13. Which antibody (IgM or IgG) crosses the placenta?
IgG
Mixed connective tissue disease
Chediak Higashi
Everything else - not right arm and right half of head

14. Which type of hypersens rxn is serum sickness?
S. aureus and S. pyogenes
Superficial inguinal pectinate line
CD14
III

15. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hereditary angioedema
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

16. What inhibits Th2 cells
IgE
Selective Ig def - IgA most common
Goodpastures
IFN gamma

17. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Adaptive
CD56
Regulates the humoral response

18. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
Scleroderma CREST
Hyperacute : occlusion - ischemia - necrosis
Macs - dendritic cell - B cell

19. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Innate
CD8 cells
SCID
Graves' dz

20. Cell surface receptors on B cels
MHC II 4 x 2=8
CD56
Trypanosomes - programmed rearrangement
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

21. Which cell mediates the type IV hypersens rxn?
CD8 cells
APCs - and DR - DP and DQ
Mesenchyme
B cell localization and proliferation

22. What are the three APCs
IL-2 and IFN gamma
Prevents attachment of bacteria and viruses to mucous membranes
IL-12 def
Macs - dendritic cell - B cell

23. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Upper limb and breast
S. aureus and S. pyogenes

24. c - ANCA
IgG
IgG
Chronic granulomatous disease
Wegeners granulomatosis

25. What is the difference in antigenic variation in viruses
Major shift minor drift
Trypanosomes - programmed rearrangement
Fab
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

26. anti U1 RNP
Upper limb and breast
Mixed connective tissue disease
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

27. Which type of hypersens rxn is immune complex mediate
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
III
Trypanosomes - programmed rearrangement

28. anti SS A/B or anti Ro/La

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29. Cell surface receptors on T cells
I
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgG
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

30. Which parts of the antibody to light chain contribute
Selective Ig def - IgA most common
Trypanosomes - programmed rearrangement
I
Fab

31. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Trypanosomes - programmed rearrangement
IFN gamma
Poly/dermato myositis
No - peptides only can can be presented on MHC molecules

32. Which antibody mediates a type Hypersens rxn?
DM type 1
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IgE
Hashimotos

33. Antimitochondrial
Il -4
Major shift minor drift
Primary biliary cirrohosis
Steroid - responsive nephrotic syndrome

34. What are the three things you find post splenectomy
Howell - Jolly bodies - Target cells - thrombocytosis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
MS - hay fever - SLE - goodpasture's
IgG

35. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
CD56
III
IL-12 - IFN- beta. IFN- alpha
DiGeorge

36. anti basement membrane
DiGeorge
I
Goodpastures
Hashimotos

37. Which cytokines to Th1 cells secrete?
IL-2 and IFN gamma
MHC II 4 x 2=8
IgG
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

38. Which kind of immunity is germline encoded?
RA
Innate
IFN gamma
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

39. Which receptor on MACS to endotoxin directy stimulate?
RA
IL-12 def
CD14
Ceilac disase

40. What does a deficiency in C1 esterase inhibitor lead to?
IL-12 - IFN- beta. IFN- alpha
CD21
III
Hereditary angioedema

41. X linked recessive defect in BTK no B cell differentiation

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42. Th cells don't produce IFN gamma - no PMN response

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43. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
No - peptides only can can be presented on MHC molecules
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IFN gamma

44. Which bacteria secrete superantigen
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
MHC I
Sjorgen's syndrome
S. aureus and S. pyogenes

45. Defect in B cell maturation
Common variable immunodeficiency (CVID)
Goodpastures
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
I

46. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
MS - hay fever - SLE - goodpasture's
No - peptides only can can be presented on MHC molecules
SLE - nonspecific

47. Which type of hypersens rxn is delayed
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IgG
IV
IgM

48. Which antibody mediates type II and type III hypersens rxn
Leukocyte adhesion deficiency type 1
CD56
IL-4 - 5 - 10
IgG

49. What does HOT- T- Bone stEAk stand for?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IL-2 and IFN gamma
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

50. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
III
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Chronic: fibrosis of graft tissue and blood vessels
Chronic granulomatous disease