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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. anti SS A/B or anti Ro/La

2. HLA- B8

3. Which type of hypersens rxn is serum sickness?
Scleroderma diffuse
III
Wegeners granulomatosis
Superficial inguinal pectinate line

4. Antimitochondrial
RA
Primary biliary cirrohosis
IgM and IgD
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

5. What are the cell surface receptors on MACS
Il -4
RA - DM type 1
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

6. Deficiency in DAF
Help B cells make antibody - secrete IFN gamma to activate macs
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
C5b -9
IgG

7. Which antibody mediates type II and type III hypersens rxn
Hyperacute : occlusion - ischemia - necrosis
MHC II 4 x 2=8
IgG
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

8. Th cells don't produce IFN gamma - no PMN response

9. What are the two signals required for B cells class switching?
S. aureus and S. pyogenes
CD8 cells
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Sjorgen's syndrome

10. What are the 3 funxtions of antibodies?
IgG
DM type 1
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Opsonization - neutralization and complement activation

11. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
IL-12
Major shift minor drift
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

12. Which is the most abundant immunoglobulin in the blood?
IFN gamma
SCID
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgG

13. Which lymph node drains the anal canal below
IgG
Selective Ig def - IgA most common
Hemochromocytosis
Superficial inguinal pectinate line

14. What is the role of CD4 cels
Scleroderma diffuse
Hemochromocytosis
No - peptides only can can be presented on MHC molecules
Help B cells make antibody - secrete IFN gamma to activate macs

15. Which portion of the antibody determines the isotype
Fc
Hyperacute : occlusion - ischemia - necrosis
IgG - IgM GM makes classic cars
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

16. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Right arm and right half of head
Mesenchyme
Corticomedullary junction

17. What does a deficiency in C3 lead to...
SCID
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Steroid - responsive nephrotic syndrome
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

18. Which areas of the body are drained by the axillary lymph node
SCID
Adaptive
Upper limb and breast
SLE

19. What are the classic example of bacterial antigen variation and the unique mechanims
Drug induced lupus
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Selective Ig def - IgA most common

20. HLA- DR4
CD8 cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
RA - DM type 1
Goodpastures

21. Which antibody mediates a type Hypersens rxn?
IgE
Leukocyte adhesion deficiency type 1
SLE
Hashimotos

22. What do mature B lymphos express on their surface?
Perforin - granzyme - granulysin
III
IgM and IgD
Hashimotos

23. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Common variable immunodeficiency (CVID)
Drug induced lupus

24. Cell surface receptors on T cells
Fc
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
SLE
Mesenchyme

25. Anti ds DNA - anti Smith
Chronic: fibrosis of graft tissue and blood vessels
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
SLE
CD40 and CD40L

26. anti - Jo 1
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Poly/dermato myositis
IgG
Goodpastures

27. Defect in LFA-1 integrin CD18 protein on phagocytes
Graves' dz
Pemphigus vulgaris
Scleroderma CREST
Leukocyte adhesion deficiency type 1

28. What is the difference in antigenic variation in viruses
Selective Ig def - IgA most common
Major shift minor drift
Primary biliary cirrohosis
MS - hay fever - SLE - goodpasture's

29. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
CD40 and CD40L
IgM and IgD
S. aureus and S. pyogenes

30. antismooth muscle
MHC II 4 x 2=8
CD14
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Autoimmune hepatitis

31. Which cytokine inhibits Th1 cells
IL-10
MHC I
Hashimotos
Scleroderma CREST

32. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
CD8 cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IL-12
DiGeorge

33. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Bruton's agamma
2
Adaptive
Pemphigus vulgaris

34. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Other vasculitidies
SLE - nonspecific
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

35. HLA- DR5
Hemochromocytosis
IL-12 - IFN- beta. IFN- alpha
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgM

36. transplant rejection: T cell and antibody mediated vasular damage
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Chronic: fibrosis of graft tissue and blood vessels
IgM
CD56

37. What does the thoracic duct drain?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Hashimotos
Everything else - not right arm and right half of head
DiGeorge

38. Defect in CD40L on helper T
SLE
Hyper IgM
IV
IgG - IgM GM makes classic cars

39. which areas of the body are drained by the celiac lymph node?
CD40 and CD40L
Stomach
Signal 1 = APC - signal 2 = B7 and CD28
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

40. Which complement proteins make up the MAC
IL-12 - IFN- beta. IFN- alpha
Help B cells make antibody - secrete IFN gamma to activate macs
C5b -9
APCs - and DR - DP and DQ

41. T cell dysfunction
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
No - peptides only can can be presented on MHC molecules
Chronic mucocutaneaous candidiasis
IgG - IgM GM makes classic cars

42. decreased Th1 response
IL-12 def
IgM and IgD
IgG
Chediak Higashi

43. Which bacteria secrete superantigen
S. aureus and S. pyogenes
Chronic granulomatous disease
Help B cells make antibody - secrete IFN gamma to activate macs
Other vasculitidies

44. Which infections require administering passive immunity?
Goodpastures
Wegeners granulomatosis
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Corticomedullary junction

45. What inhibits Th2 cells
Howell - Jolly bodies - Target cells - thrombocytosis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IgG - IgM GM makes classic cars
IFN gamma

46. Transplant rejection: preformed host antibody mediated
Hyperacute : occlusion - ischemia - necrosis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Chronic granulomatous disease
Primary biliary cirrohosis

47. which follicles (primary or secondary) have active germinal centers?
CD8 cells
C5b -9
IL-12 def
Secondary

48. Defectin in isotype switching
Sjorgen's syndrome
Selective Ig def - IgA most common
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Fc and Fab

49. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
CD8 cells
SCID
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

50. X linked recessive defect in BTK no B cell differentiation