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Immunology

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Answer 50 questions in 15 minutes.
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1. What are the classic example of bacterial antigen variation and the unique mechanims
Goodpastures
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

2. What are the three APCs
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Macs - dendritic cell - B cell
CD56
Mixed connective tissue disease

3. Which areas of the body are drained by the axillary lymph node
Macs - dendritic cell - B cell
Upper limb and breast
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

4. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Sjorgen's syndrome
Steroid - responsive nephrotic syndrome
IL-2 and IFN gamma

5. Which type of hypersens rxn is the arthus rxn
III
SLE
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Hemochromocytosis

6. What are the two signals in helper T activation?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgG
Signal 1 = APC - signal 2 = B7 and CD28
Leukocyte adhesion deficiency type 1

7. Which B T cell interaction allows for immunologic memory and class switching?
Poly/dermato myositis
Steroid - responsive nephrotic syndrome
C3b
CD40 and CD40L

8. Which parts of the antibody to light chain contribute
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Secondary
Fab
MS - hay fever - SLE - goodpasture's

9. Which complement protein opsonizes bacteria?
CD40 and CD40L
C3b
IgG
2

10. anti glutamate decarboxylase
Neisseria bacteremia
Upper limb and breast
Drug induced lupus
DM type 1

11. Which kind of immunity is germline encoded?
Innate
Scleroderma diffuse
IgM
Ataxia telangectasia

12. What kind of hypersens rxn in anaphylaxis
I
Right arm and right half of head
DM type 1
Hashimotos

13. Antihistone
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Il -4
Drug induced lupus
Autoimmune hepatitis

14. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Other vasculitidies
CD40 and CD40L
Ataxia telangectasia

15. Which is the receptors for EBV?
Scleroderma diffuse
CD21
MHC II 4 x 2=8
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

16. ANA
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Adaptive
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
SLE - nonspecific

17. HLA- D2

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18. Which lymph node drains the anal canal below
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Superficial inguinal pectinate line
IgG - IgM GM makes classic cars
DM type 1

19. Which infections require administering passive immunity?
Ceilac disase
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Scleroderma diffuse
Chronic mucocutaneaous candidiasis

20. AR - defect in microtubule fxn with decreased phagocytosis
RA - DM type 1
Chediak Higashi
IL-10
SLE - nonspecific

21. anti basement membrane
IFN gamma
Goodpastures
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

22. HLA- B27

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23. HLA- A3
Fab
IgM
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Hemochromocytosis

24. Where do positive and negative selection occur in the thymus?
IL-12 def
Chronic mucocutaneaous candidiasis
Trypanosomes - programmed rearrangement
Corticomedullary junction

25. Which parts of the antibody to heavy chain contribute?
Fc and Fab
DM type 1
Scleroderma diffuse
IL-2 and IFN gamma

26. What kind of bacteria do macrophages remove from the spleen?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
CD8 cells
IgE

27. What are the cell surface receptors on MACS
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Autoimmune hepatitis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
DM type 1

28. Which parasites exhibit antigenic variation
Chediak Higashi
Trypanosomes - programmed rearrangement
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

29. Which antibodies activate the classic pathway
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG
IgG - IgM GM makes classic cars
Adaptive

30. What does clean up on Aisle 8 stand for?
Scleroderma diffuse
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IgE
PMNs recruited by IL-8 to clear infxns

31. transplant rejection: T cell and antibody mediated vasular damage
IV
Goodpastures
Fc and Fab
Chronic: fibrosis of graft tissue and blood vessels

32. HLA- DR7
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Pemphigus vulgaris
II
Steroid - responsive nephrotic syndrome

33. What do you find in the medulla of the thymus?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Paracortex
Prevents attachment of bacteria and viruses to mucous membranes

34. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
2
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgM
CD21

35. Which cell mediates the type IV hypersens rxn?
CD40 and CD40L
Chronic mucocutaneaous candidiasis
CD8 cells
MS - hay fever - SLE - goodpasture's

36. HLA- B8

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37. Defectin in isotype switching
I
IgG
Paracortex
Selective Ig def - IgA most common

38. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Major shift minor drift
B cell localization and proliferation
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
No - peptides only can can be presented on MHC molecules

39. Anti - IgG (RF)
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Paracortex
IgA
RA

40. How do NK cells kill?
Wegeners granulomatosis
C3b
RA - DM type 1
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

41. Th cells don't produce IFN gamma - no PMN response

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42. Which antibody (IgM or IgG) crosses the placenta?
Fc
IgG
DiGeorge
No - peptides only can can be presented on MHC molecules

43. What does a deficiency in C5- C8 lead to?
IL-12
IL-2 and IFN gamma
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Neisseria bacteremia

44. Defect in LFA-1 integrin CD18 protein on phagocytes
DM type 1
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Leukocyte adhesion deficiency type 1
Fc

45. What does HOT- T- Bone stEAk stand for?
Chediak Higashi
DM type 1
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Ceilac disase

46. What are the 3 funxtions of antibodies?
Bruton's agamma
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Opsonization - neutralization and complement activation

47. antidesmoglein
Pemphigus vulgaris
Everything else - not right arm and right half of head
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Secondary

48. Which cytokines to Th1 cells secrete?
Trypanosomes - programmed rearrangement
IL-2 and IFN gamma
II
Other vasculitidies

49. Anti Scl 70 (DNA topo I
DM type 1
Primary biliary cirrohosis
IL-2 and IFN gamma
Scleroderma diffuse

50. What happens in the follicle of the lymph node
Mixed connective tissue disease
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
B cell localization and proliferation
Pemphigus vulgaris

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