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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. c - ANCA
Hemochromocytosis
Wegeners granulomatosis
I
Opsonization - neutralization and complement activation

2. Anticentromere
Wegeners granulomatosis
DM type 1
Scleroderma CREST
Adaptive

3. What are the two signals in helper T activation?
I
IgG - IgM GM makes classic cars
Signal 1 = APC - signal 2 = B7 and CD28
IgM

4. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
IgG
Trypanosomes - programmed rearrangement
IL-12 - IFN- beta. IFN- alpha

5. Where do positive and negative selection occur in the thymus?
Corticomedullary junction
IgM
IgG
RA - DM type 1

6. HLA- A3
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
MHC I
III
Hemochromocytosis

7. Cell surface receptors on T cells
Scleroderma diffuse
Stomach
IL-2 and IFN gamma
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

8. How do CD8 cells kill?
IFN gamma
Perforin - granzyme - granulysin
SLE
DM type 1

9. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
Mixed connective tissue disease
Paracortex
RA

10. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
DM type 1
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Chediak Higashi

11. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
No - peptides only can can be presented on MHC molecules
IFN gamma
CD14

12. What inhibits Th2 cells
IFN gamma
Sjorgen's syndrome
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

13. T cell dysfunction
CD21
Common variable immunodeficiency (CVID)
Chronic mucocutaneaous candidiasis
B cell localization and proliferation

14. Which antibodies activate the classic pathway
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
All nucleated cells (no RBCs) A - B - C
IgG - IgM GM makes classic cars
Perforin - granzyme - granulysin

15. What are the three things you find post splenectomy
B cell localization and proliferation
Howell - Jolly bodies - Target cells - thrombocytosis
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Scleroderma CREST

16. antimicrosomal - antithyroglobulin
Upper limb and breast
Help B cells make antibody - secrete IFN gamma to activate macs
Hashimotos
SCID

17. What do you find in the medulla of the thymus?
SLE - nonspecific
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Upper limb and breast
Leukocyte adhesion deficiency type 1

18. Defect in LFA-1 integrin CD18 protein on phagocytes
IgA
Leukocyte adhesion deficiency type 1
CD14
Secondary

19. What does HOT- T- Bone stEAk stand for?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Graves' dz
CD56
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

20. HLA- B27

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21. Which antibody mediates type II and type III hypersens rxn
Paracortex
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Everything else - not right arm and right half of head
IgG

22. Th cells don't produce IFN gamma - no PMN response

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23. What are the classic example of bacterial antigen variation and the unique mechanims
Mixed connective tissue disease
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
SLE
DiGeorge

24. HLA- D2

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25. What are the three APCs
Macs - dendritic cell - B cell
Drug induced lupus
SLE - nonspecific
IgE

26. Defect in CD40L on helper T
Selective Ig def - IgA most common
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IL-4 - 5 - 10
Hyper IgM

27. What is the role of CD4 cels
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IV
IgG - IgM GM makes classic cars
Help B cells make antibody - secrete IFN gamma to activate macs

28. X linked recessive defect in BTK no B cell differentiation

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29. What is the clinical picture for serum sickness?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Fc
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

30. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Chediak Higashi
III
Sjorgen's syndrome

31. Which type of hypersens rxn is immune complex mediate
RA - DM type 1
Other vasculitidies
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
III

32. Which complement proteins make up the MAC
DM type 1
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
C5b -9
Mesenchyme

33. HLA- DR5
Opsonization - neutralization and complement activation
Chronic mucocutaneaous candidiasis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Stomach

34. Which areas of the body are drained by the axillary lymph node
Trypanosomes - programmed rearrangement
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Hyper IgE syndrome (Job's)
Upper limb and breast

35. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
RA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Chronic granulomatous disease
Ataxia telangectasia

36. Anti ds DNA - anti Smith
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
SLE

37. How do NK cells kill?
Signal 1 = APC - signal 2 = B7 and CD28
Autoimmune hepatitis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

38. What is the difference in antigenic variation in viruses
IV
Fc and Fab
Major shift minor drift
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

39. What does a deficiency in C5- C8 lead to?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Corticomedullary junction
Neisseria bacteremia
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

40. Defect in DNA repair enzymes
Ataxia telangectasia
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
B cell localization and proliferation
Opsonization - neutralization and complement activation

41. What does a deficiency in C3 lead to...
S. aureus and S. pyogenes
Everything else - not right arm and right half of head
Hyper IgE syndrome (Job's)
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

42. Which complement protein opsonizes bacteria?
Wegeners granulomatosis
I
C3b
Mature t cells - epithelial reticular cells - Hassalls corpuscles

43. antigliadin - antiendomysial
III
Ceilac disase
Superficial inguinal pectinate line
RA

44. HLA- DR4
Bruton's agamma
RA - DM type 1
C3b
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

45. What cytokines to Th2 cells secrete?
Chronic: fibrosis of graft tissue and blood vessels
IL-4 - 5 - 10
Prevents attachment of bacteria and viruses to mucous membranes
Fc and Fab

46. transplant rejection: T cell and antibody mediated vasular damage
Bruton's agamma
IL-12
Chronic: fibrosis of graft tissue and blood vessels
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

47. Transplant rejection: preformed host antibody mediated
IL-2 and IFN gamma
Other vasculitidies
Hyperacute : occlusion - ischemia - necrosis
Ceilac disase

48. Where is MHC II expressed and and which HLA molecules codes for it
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Mature t cells - epithelial reticular cells - Hassalls corpuscles
APCs - and DR - DP and DQ
Hyper IgM

49. Which antibody mediates a type Hypersens rxn?
Hyper IgM
IgE
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IL-12 def

50. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
IgE
No - peptides only can can be presented on MHC molecules
Pernicious anemia (to B12 def) - hashimotos thyroiditis