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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. How do CD8 cells kill?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgG
DM type 1
Perforin - granzyme - granulysin

2. Which cell mediates the type IV hypersens rxn?
CD8 cells
Stomach
Drug induced lupus
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

3. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgE
Hereditary angioedema
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

4. HLA- DR3
Right arm and right half of head
Selective Ig def - IgA most common
CD21
DM type 1

5. Which type of hypersens rxn is antibody mediated?
II
Selective Ig def - IgA most common
Goodpastures
IL-10

6. What does a deficiency in C3 lead to...
DM type 1
Chronic: fibrosis of graft tissue and blood vessels
Scleroderma CREST
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

7. Which B T cell interaction allows for immunologic memory and class switching?
B cell localization and proliferation
IL-12
IgG
CD40 and CD40L

8. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hyper IgE syndrome (Job's)
PMNs recruited by IL-8 to clear infxns

9. What does a deficiency in C1 esterase inhibitor lead to?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Right arm and right half of head
CD40 and CD40L
Hereditary angioedema

10. Which type of hypersens rxn is delayed
CD14
Pemphigus vulgaris
Opsonization - neutralization and complement activation
IV

11. which areas of the body are drained by the celiac lymph node?
CD8 cells
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Stomach
IL-12 - IFN- beta. IFN- alpha

12. c - ANCA
MHC II 4 x 2=8
Superficial inguinal pectinate line
IL-12 - IFN- beta. IFN- alpha
Wegeners granulomatosis

13. p - ANCA
IgG
IL-12 def
Other vasculitidies
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

14. HLA- B27

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15. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Goodpastures
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Neisseria bacteremia

16. Which complement proteins make up the MAC
III
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Hyper IgM
C5b -9

17. Which antibodies activate the classic pathway
Hereditary angioedema
Everything else - not right arm and right half of head
Poly/dermato myositis
IgG - IgM GM makes classic cars

18. anti glutamate decarboxylase
CD40 and CD40L
IL-12
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
DM type 1

19. Which MHC complex to CD8 cells bind
IgM and IgD
Leukocyte adhesion deficiency type 1
MHC I
Adaptive

20. How are NK cells stimulated?
Hemochromocytosis
IL-12 - IFN- beta. IFN- alpha
Prevents attachment of bacteria and viruses to mucous membranes
DiGeorge

21. Which parasites exhibit antigenic variation
IgM and IgD
Signal 1 = APC - signal 2 = B7 and CD28
Graves' dz
Trypanosomes - programmed rearrangement

22. Which cytokines to Th1 cells secrete?
IgM
Poly/dermato myositis
IL-2 and IFN gamma
RA

23. What are the classic example of bacterial antigen variation and the unique mechanims
Major shift minor drift
CD21
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

24. What is the unique cell marker for NK cells
IgM and IgD
Perforin - granzyme - granulysin
III
CD56

25. Which type of hypersens rxn is the arthus rxn
Upper limb and breast
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
III
Bruton's agamma

26. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Mesenchyme
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

27. What is the arthus rxn?
IgE
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
MHC I
IL-10

28. What are the cell surface receptors on MACS
IgG - IgM GM makes classic cars
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Chronic granulomatous disease
Mixed connective tissue disease

29. Which cytokine induces Th1 cell profile in CD4 cells
Chediak Higashi
B cell localization and proliferation
Prevents attachment of bacteria and viruses to mucous membranes
IL-12

30. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Everything else - not right arm and right half of head
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

31. X linked recessive defect in BTK no B cell differentiation

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32. What are the three things you find post splenectomy
Paracortex
Howell - Jolly bodies - Target cells - thrombocytosis
CD56
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

33. What inhibits Th2 cells
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Corticomedullary junction
MHC I
IFN gamma

34. Defect in B cell maturation
No - peptides only can can be presented on MHC molecules
Common variable immunodeficiency (CVID)
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Steroid - responsive nephrotic syndrome

35. ANA
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Graves' dz
SLE - nonspecific

36. Which cytokine inhibits Th1 cells
III
IL-10
S. aureus and S. pyogenes
Signal 1 = APC - signal 2 = B7 and CD28

37. What is the main function of IgA
SLE
Prevents attachment of bacteria and viruses to mucous membranes
Primary biliary cirrohosis
Chronic granulomatous disease

38. Which infections require administering passive immunity?
IL-12
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

39. What are the three APCs
Macs - dendritic cell - B cell
C5b -9
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Fc and Fab

40. transplant rejection: T cell and antibody mediated vasular damage
IgG
Chronic: fibrosis of graft tissue and blood vessels
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Mixed connective tissue disease

41. antidesmoglein
Help B cells make antibody - secrete IFN gamma to activate macs
Pemphigus vulgaris
CD40 and CD40L
PMNs recruited by IL-8 to clear infxns

42. anti SS A/B or anti Ro/La

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43. Which bacteria secrete superantigen
CD40 and CD40L
Fc and Fab
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
S. aureus and S. pyogenes

44. Which is the receptors for EBV?
B cell localization and proliferation
CD21
Signal 1 = APC - signal 2 = B7 and CD28
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

45. anti - Jo 1
Poly/dermato myositis
Steroid - responsive nephrotic syndrome
Wegeners granulomatosis
Howell - Jolly bodies - Target cells - thrombocytosis

46. Which portion of the antibody determines the isotype
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Innate
Fab
Fc

47. antigliadin - antiendomysial
Ceilac disase
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Pernicious anemia (to B12 def) - hashimotos thyroiditis

48. Which antibody mediates type II and type III hypersens rxn
C3b
IgG
I
Il -4

49. Antimitochondrial
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-12
Primary biliary cirrohosis
II

50. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
MHC I
Primary biliary cirrohosis
Hyper IgE syndrome (Job's)