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Immunology

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Answer 50 questions in 15 minutes.
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1. What is the arthus rxn?
Adaptive
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Macs - dendritic cell - B cell
Graves' dz

2. What cytokines to Th2 cells secrete?
Scleroderma diffuse
IL-4 - 5 - 10
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

3. X- linked recessive defect with progessive deletion of B and T cells
Pemphigus vulgaris
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Common variable immunodeficiency (CVID)
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

4. Which MHC complex to CD4 cells bind
Hyper IgE syndrome (Job's)
2
MHC II 4 x 2=8
IgE

5. Which antibody (IgM or IgG) crosses the placenta?
IgE
Right arm and right half of head
Corticomedullary junction
IgG

6. Which complement proteins make up the MAC
IgE
C5b -9
Upper limb and breast
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

7. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
C5b -9
Hereditary angioedema
IV

8. Cell surface receptors on T cells
Superficial inguinal pectinate line
Fc and Fab
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Prevents attachment of bacteria and viruses to mucous membranes

9. Which is the most abundant immunoglobulin in the blood?
IL-10
Fc
IgG
IL-4 - 5 - 10

10. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Stomach
Il -4
Trypanosomes - programmed rearrangement

11. What does the thoracic duct drain?
III
Hemochromocytosis
Pemphigus vulgaris
Everything else - not right arm and right half of head

12. Which parts of the antibody to heavy chain contribute?
SLE - nonspecific
IL-2 and IFN gamma
Fc and Fab
Howell - Jolly bodies - Target cells - thrombocytosis

13. anti U1 RNP
Graves' dz
Mixed connective tissue disease
All nucleated cells (no RBCs) A - B - C
Poly/dermato myositis

14. decreased Th1 response
IL-12 def
Signal 1 = APC - signal 2 = B7 and CD28
Perforin - granzyme - granulysin
Ataxia telangectasia

15. What does clean up on Aisle 8 stand for?
CD8 cells
IL-4 - 5 - 10
PMNs recruited by IL-8 to clear infxns
Chronic: fibrosis of graft tissue and blood vessels

16. What does a deficiency in C3 lead to...
CD21
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Scleroderma CREST
MHC II 4 x 2=8

17. HLA- DR3
DM type 1
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MHC II 4 x 2=8
Wegeners granulomatosis

18. Cell surface receptors on B cels
Autoimmune hepatitis
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Other vasculitidies
Sjorgen's syndrome

19. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
IV
DiGeorge
IgG
SCID

20. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
II
CD8 cells
Scleroderma diffuse

21. What kind of hypersens rxn in anaphylaxis
RA
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
I
Other vasculitidies

22. Defect in B cell maturation
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Poly/dermato myositis
Common variable immunodeficiency (CVID)
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

23. What does a deficiency in C5- C8 lead to?
Howell - Jolly bodies - Target cells - thrombocytosis
Neisseria bacteremia
Mesenchyme
APCs - and DR - DP and DQ

24. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgM
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Everything else - not right arm and right half of head

25. Which area of the lymph node englarges in an extreme immune response
Paracortex
Common variable immunodeficiency (CVID)
RA
III

26. How do CD8 cells kill?
Perforin - granzyme - granulysin
IgE
III
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

27. Which cytokine induces Th1 cell profile in CD4 cells
Opsonization - neutralization and complement activation
IL-12
Bruton's agamma
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

28. What inhibits Th2 cells
IFN gamma
SLE
Scleroderma CREST
Other vasculitidies

29. What are the classic example of bacterial antigen variation and the unique mechanims
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

30. HLA- B27

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31. Defect in LFA-1 integrin CD18 protein on phagocytes
Sjorgen's syndrome
Leukocyte adhesion deficiency type 1
Bruton's agamma
RA - DM type 1

32. What are the 3 funxtions of antibodies?
Upper limb and breast
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Opsonization - neutralization and complement activation
IgA

33. Which antibodies activate the classic pathway
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
CD8 cells
IgG - IgM GM makes classic cars
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

34. How many signals are required for T cell activation or B cell class switching?
IV
IL-4 - 5 - 10
2
Chronic mucocutaneaous candidiasis

35. Transplant rejection: preformed host antibody mediated
PMNs recruited by IL-8 to clear infxns
III
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Hyperacute : occlusion - ischemia - necrosis

36. Which type of hypersens rxn is serum sickness?
III
Hyper IgE syndrome (Job's)
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

37. Which immunoglobulin is a pentamer
C5b -9
IgM
Hyperacute : occlusion - ischemia - necrosis
Pernicious anemia (to B12 def) - hashimotos thyroiditis

38. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
IFN gamma
Help B cells make antibody - secrete IFN gamma to activate macs
Chronic granulomatous disease

39. What are the two signals in cytotoxic T cells activation?
IgE
Scleroderma CREST
Hyperacute : occlusion - ischemia - necrosis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

40. T cell dysfunction
Upper limb and breast
Paracortex
RA - DM type 1
Chronic mucocutaneaous candidiasis

41. anti basement membrane
DM type 1
Goodpastures
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
RA

42. Which type of hypersens rxn is immune complex mediate
III
Macs - dendritic cell - B cell
SLE
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

43. What is the unique cell marker for NK cells
CD56
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-12
II

44. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
PMNs recruited by IL-8 to clear infxns
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Steroid - responsive nephrotic syndrome
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

45. Which type of hypersens rxn is antibody mediated?
Primary biliary cirrohosis
PMNs recruited by IL-8 to clear infxns
Selective Ig def - IgA most common
II

46. What is the clinical picture for serum sickness?
Everything else - not right arm and right half of head
IgM
PMNs recruited by IL-8 to clear infxns
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

47. What are the cytokines involved in macrophage/lymphocyte interaction
Pemphigus vulgaris
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Hemochromocytosis

48. antimicrosomal - antithyroglobulin
Hashimotos
Hyper IgE syndrome (Job's)
Neisseria bacteremia
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

49. Anti Scl 70 (DNA topo I
Scleroderma diffuse
SLE
Leukocyte adhesion deficiency type 1
Chronic granulomatous disease

50. anti - Jo 1
Poly/dermato myositis
Chediak Higashi
No - peptides only can can be presented on MHC molecules
Scleroderma diffuse

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