Test your basic knowledge |

Immunology

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which immunoglobulin is a pentamer
RA
CD14
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgM

2. Which antibodies activate the classic pathway
Hyper IgE syndrome (Job's)
Graves' dz
IgG - IgM GM makes classic cars
Scleroderma diffuse

3. What is the unique cell marker for NK cells
Major shift minor drift
CD56
IFN gamma
Drug induced lupus

4. Anti Scl 70 (DNA topo I
Scleroderma diffuse
DM type 1
III
Everything else - not right arm and right half of head

5. transplant rejection: T cell and antibody mediated vasular damage
Prevents attachment of bacteria and viruses to mucous membranes
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hemochromocytosis
Chronic: fibrosis of graft tissue and blood vessels

6. Th cells don't produce IFN gamma - no PMN response

7. T cell dysfunction
Chronic mucocutaneaous candidiasis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Perforin - granzyme - granulysin
Il -4

8. Defect in CD40L on helper T
IL-12 def
IL-2 and IFN gamma
Hyper IgM
Upper limb and breast

9. Which antibody mediates type II and type III hypersens rxn
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Major shift minor drift
Adaptive
IgG

10. What happens in the follicle of the lymph node
C3b
Fc
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
B cell localization and proliferation

11. How are NK cells stimulated?
Mixed connective tissue disease
IgE
IL-12 - IFN- beta. IFN- alpha
Upper limb and breast

12. HLA- DR5
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Hyper IgE syndrome (Job's)
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

13. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Bruton's agamma
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IV

14. What are the three APCs
IL-10
MS - hay fever - SLE - goodpasture's
Macs - dendritic cell - B cell
II

15. What kind of hypersens rxn in anaphylaxis
IgM
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
I
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

16. Which MHC complex to CD8 cells bind
IgG
Upper limb and breast
MHC I
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

17. Which parts of the antibody to light chain contribute
Fc and Fab
Fab
Bruton's agamma
DiGeorge

18. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
C5b -9
SCID
Scleroderma diffuse
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

19. What is the main function of IgA
IFN gamma
Prevents attachment of bacteria and viruses to mucous membranes
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Mixed connective tissue disease

20. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgM and IgD
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

21. What do you find in the medulla of the thymus?
IgG
Autoimmune hepatitis
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Chronic: fibrosis of graft tissue and blood vessels

22. X linked recessive defect in BTK no B cell differentiation

23. Which is the most abundant immunoglobulin in the blood?
IgG
PMNs recruited by IL-8 to clear infxns
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Other vasculitidies

24. c - ANCA
Opsonization - neutralization and complement activation
Wegeners granulomatosis
Hemochromocytosis
III

25. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
III
Chronic mucocutaneaous candidiasis
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

26. What is the arthus rxn?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-2 and IFN gamma
Secondary
Mesenchyme

27. Which type of hypersens rxn is immune complex mediate
Drug induced lupus
DM type 1
III
Paracortex

28. Which cytokine inhibits Th1 cells
IL-10
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Leukocyte adhesion deficiency type 1
Major shift minor drift

29. anti U1 RNP
IgE
Mesenchyme
Mixed connective tissue disease
Upper limb and breast

30. HLA- A3
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Paracortex
Hemochromocytosis
Adaptive

31. What are the cell surface receptors on MACS
Neisseria bacteremia
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Goodpastures
Drug induced lupus

32. antidesmoglein
Scleroderma CREST
Pemphigus vulgaris
IL-4 - 5 - 10
Mixed connective tissue disease

33. HLA- DR3
DM type 1
IgM
Mesenchyme
IgG - IgM GM makes classic cars

34. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
IgE
Mesenchyme
Opsonization - neutralization and complement activation

35. What does a deficiency in C5- C8 lead to?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgG - IgM GM makes classic cars
Neisseria bacteremia
Pernicious anemia (to B12 def) - hashimotos thyroiditis

36. What interferes with viruses?
No - peptides only can can be presented on MHC molecules
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Chediak Higashi

37. HLA- D2

38. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
Fc
Corticomedullary junction
Bruton's agamma

39. What are the two signals in cytotoxic T cells activation?
Major shift minor drift
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Mesenchyme
Wegeners granulomatosis

40. What embryologic tissue are lymphcytes derived from
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Drug induced lupus
Mesenchyme
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

41. Which parasites exhibit antigenic variation
Howell - Jolly bodies - Target cells - thrombocytosis
Trypanosomes - programmed rearrangement
Paracortex
SLE - nonspecific

42. What are the cytokines involved in macrophage/lymphocyte interaction
CD40 and CD40L
Stomach
Hyper IgE syndrome (Job's)
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

43. Which bacteria secrete superantigen
S. aureus and S. pyogenes
DM type 1
C3b
SLE - nonspecific

44. Which parts of the antibody to heavy chain contribute?
CD8 cells
CD40 and CD40L
IFN gamma
Fc and Fab

45. Which complement protein opsonizes bacteria?
CD40 and CD40L
Common variable immunodeficiency (CVID)
C3b
CD56

46. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Mesenchyme
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Signal 1 = APC - signal 2 = B7 and CD28
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

47. What is the difference in antigenic variation in viruses
IL-12
Common variable immunodeficiency (CVID)
Major shift minor drift
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

48. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
No - peptides only can can be presented on MHC molecules
C5b -9
APCs - and DR - DP and DQ

49. HLA- DR4
Hereditary angioedema
Bruton's agamma
RA - DM type 1
Corticomedullary junction

50. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
Pemphigus vulgaris
Chediak Higashi
Opsonization - neutralization and complement activation