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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Th cells don't produce IFN gamma - no PMN response

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2. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
IL-4 - 5 - 10
Sjorgen's syndrome
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

3. which follicles (primary or secondary) have active germinal centers?
IgG
Secondary
DM type 1
Opsonization - neutralization and complement activation

4. What inhibits Th2 cells
Leukocyte adhesion deficiency type 1
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IFN gamma
Hyper IgM

5. Which MHC complex to CD4 cells bind
MHC II 4 x 2=8
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Upper limb and breast
Autoimmune hepatitis

6. Antihistone
IgM and IgD
IgG - IgM GM makes classic cars
Howell - Jolly bodies - Target cells - thrombocytosis
Drug induced lupus

7. Which type of hypersens rxn is immune complex mediate
Chronic granulomatous disease
Fab
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
III

8. Where do positive and negative selection occur in the thymus?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Corticomedullary junction
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
RA

9. What embryologic tissue are lymphcytes derived from
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Mesenchyme
DM type 1
Neisseria bacteremia

10. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Help B cells make antibody - secrete IFN gamma to activate macs
Paracortex
Opsonization - neutralization and complement activation

11. p - ANCA
Other vasculitidies
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Fc and Fab
Fc

12. AR - defect in microtubule fxn with decreased phagocytosis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-4 - 5 - 10
Chediak Higashi
IL-2 and IFN gamma

13. Which cytokine inhibits Th1 cells
Upper limb and breast
Everything else - not right arm and right half of head
IL-10
Mature t cells - epithelial reticular cells - Hassalls corpuscles

14. Which parts of the antibody to light chain contribute
Ceilac disase
Ataxia telangectasia
CD40 and CD40L
Fab

15. What are the 4 T's of type IV hypersense
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Steroid - responsive nephrotic syndrome
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Other vasculitidies

16. What are the three APCs
Macs - dendritic cell - B cell
IgG
Help B cells make antibody - secrete IFN gamma to activate macs
C3b

17. HLA- DR7
Ataxia telangectasia
Autoimmune hepatitis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Steroid - responsive nephrotic syndrome

18. decreased Th1 response
Neisseria bacteremia
IL-12 def
Opsonization - neutralization and complement activation
IgG

19. antidesmoglein
MS - hay fever - SLE - goodpasture's
Goodpastures
Pemphigus vulgaris
CD8 cells

20. Which is the receptors for EBV?
Upper limb and breast
CD8 cells
CD21
Mature t cells - epithelial reticular cells - Hassalls corpuscles

21. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Chronic granulomatous disease
Opsonization - neutralization and complement activation
CD14

22. Which antibody (IgM or IgG) crosses the placenta?
Pemphigus vulgaris
IgG
Wegeners granulomatosis
IL-4 - 5 - 10

23. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Hemochromocytosis
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

24. What do superantigens do?
Innate
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Scleroderma diffuse
Upper limb and breast

25. What does a deficiency in C1 esterase inhibitor lead to?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IFN gamma
Help B cells make antibody - secrete IFN gamma to activate macs
Hereditary angioedema

26. Cell surface receptors on T cells
Chronic granulomatous disease
Autoimmune hepatitis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
MHC II 4 x 2=8

27. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
III
Opsonization - neutralization and complement activation
Bruton's agamma

28. Which areas of the body are drained by the axillary lymph node
Hemochromocytosis
Upper limb and breast
Chediak Higashi
III

29. Which immunoglobulin is a pentamer
Trypanosomes - programmed rearrangement
Perforin - granzyme - granulysin
IgM
Poly/dermato myositis

30. HLA- DR5
Pernicious anemia (to B12 def) - hashimotos thyroiditis
CD14
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IgM and IgD

31. Which cytokine induces Th1 cell profile in CD4 cells
Right arm and right half of head
III
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IL-12

32. How do CD8 cells kill?
Perforin - granzyme - granulysin
MS - hay fever - SLE - goodpasture's
C3b
Leukocyte adhesion deficiency type 1

33. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
MHC I
Mesenchyme
III

34. Where is MHC II expressed and and which HLA molecules codes for it
Poly/dermato myositis
MS - hay fever - SLE - goodpasture's
APCs - and DR - DP and DQ
RA

35. HLA- DR3
Hyperacute : occlusion - ischemia - necrosis
DM type 1
RA
Il -4

36. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
IL-12 - IFN- beta. IFN- alpha
Primary biliary cirrohosis
IL-2 and IFN gamma

37. Deficiency in DAF
II
Other vasculitidies
Regulates the humoral response
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

38. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
MS - hay fever - SLE - goodpasture's
Sjorgen's syndrome
Superficial inguinal pectinate line

39. Which antibody mediates a type Hypersens rxn?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Innate
IgG - IgM GM makes classic cars
IgE

40. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
IgG
Perforin - granzyme - granulysin
IL-12 - IFN- beta. IFN- alpha

41. What are the three things you find post splenectomy
IL-4 - 5 - 10
Howell - Jolly bodies - Target cells - thrombocytosis
IgG
IV

42. Antimitochondrial
IV
Primary biliary cirrohosis
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Bruton's agamma

43. which areas of the body are drained by the celiac lymph node?
Stomach
Corticomedullary junction
IL-10
Secondary

44. Anti - IgG (RF)
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgG
Fc
RA

45. anti basement membrane
Goodpastures
IgM
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Chronic: fibrosis of graft tissue and blood vessels

46. Which cytokine induces Th2 cell profile in CD4 cells
Scleroderma diffuse
Chronic mucocutaneaous candidiasis
Il -4
All nucleated cells (no RBCs) A - B - C

47. Transplant rejection: preformed host antibody mediated
Hyperacute : occlusion - ischemia - necrosis
MS - hay fever - SLE - goodpasture's
Chediak Higashi
Adaptive

48. Which is the most abundant immunoglobulin in the blood?
CD40 and CD40L
Corticomedullary junction
IgG
C5b -9

49. What are the classic example of bacterial antigen variation and the unique mechanims
Other vasculitidies
IL-12 def
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

50. Which parts of the antibody to heavy chain contribute?
All nucleated cells (no RBCs) A - B - C
Secondary
RA - DM type 1
Fc and Fab