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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Ceilac disase
Fc

2. Which type of hypersens rxn is serum sickness?
Sjorgen's syndrome
Bruton's agamma
III
Chronic: fibrosis of graft tissue and blood vessels

3. What interferes with viruses?
Howell - Jolly bodies - Target cells - thrombocytosis
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Pernicious anemia (to B12 def) - hashimotos thyroiditis

4. anti SS A/B or anti Ro/La

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5. Transplant rejection: preformed host antibody mediated
Hyperacute : occlusion - ischemia - necrosis
C3b
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
C5b -9

6. Which type of hypersens rxn is delayed
IV
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Everything else - not right arm and right half of head
Regulates the humoral response

7. Which lymph node drains the anal canal below
Superficial inguinal pectinate line
Major shift minor drift
Fc and Fab
Bruton's agamma

8. Which antibody (IgM or IgG) crosses the placenta?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Corticomedullary junction
CD40 and CD40L
IgG

9. Defect in CD40L on helper T
Hyper IgM
Goodpastures
Opsonization - neutralization and complement activation
Wegeners granulomatosis

10. Which complement protein opsonizes bacteria?
C3b
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Graves' dz
Goodpastures

11. Which MHC complex to CD8 cells bind
No - peptides only can can be presented on MHC molecules
II
MHC I
Sjorgen's syndrome

12. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Corticomedullary junction
Chronic mucocutaneaous candidiasis
Superficial inguinal pectinate line

13. Which MHC complex to CD4 cells bind
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
MHC II 4 x 2=8
IgG
Mesenchyme

14. transplant rejection: T cell and antibody mediated vasular damage
Fab
Chronic: fibrosis of graft tissue and blood vessels
Hereditary angioedema
Hyper IgE syndrome (Job's)

15. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Adaptive
Hereditary angioedema
Upper limb and breast

16. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Chronic: fibrosis of graft tissue and blood vessels
Drug induced lupus
SCID

17. What are the three things you find post splenectomy
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Right arm and right half of head
Howell - Jolly bodies - Target cells - thrombocytosis
II

18. antidesmoglein
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgA
Major shift minor drift
Pemphigus vulgaris

19. Which immunoglobulin is a pentamer
Il -4
IgM
MHC II 4 x 2=8
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

20. Antihistone
Macs - dendritic cell - B cell
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Howell - Jolly bodies - Target cells - thrombocytosis
Drug induced lupus

21. Which complement proteins make up the MAC
C5b -9
Primary biliary cirrohosis
Adaptive
DM type 1

22. anti basement membrane
Goodpastures
MHC I
IgA
Fab

23. What is the clinical picture for serum sickness?
CD40 and CD40L
Right arm and right half of head
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

24. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IL-4 - 5 - 10
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgA

25. p - ANCA
Other vasculitidies
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Steroid - responsive nephrotic syndrome
Prevents attachment of bacteria and viruses to mucous membranes

26. Anti - IgG (RF)
Major shift minor drift
RA
Graves' dz
Mature t cells - epithelial reticular cells - Hassalls corpuscles

27. Defect in LFA-1 integrin CD18 protein on phagocytes
Fc
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Il -4
Leukocyte adhesion deficiency type 1

28. Defect in B cell maturation
Goodpastures
PMNs recruited by IL-8 to clear infxns
Chediak Higashi
Common variable immunodeficiency (CVID)

29. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
No - peptides only can can be presented on MHC molecules
IgM
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

30. What are the cytokines involved in macrophage/lymphocyte interaction
IgE
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Sjorgen's syndrome

31. Which cytokines to Th1 cells secrete?
Ceilac disase
IL-2 and IFN gamma
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Stomach

32. What does clean up on Aisle 8 stand for?
C3b
Regulates the humoral response
PMNs recruited by IL-8 to clear infxns
CD56

33. HLA- B8

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34. Where is MHC I expressed - and which HLA molecules code for it
Hyper IgE syndrome (Job's)
IgA
All nucleated cells (no RBCs) A - B - C
Goodpastures

35. What are the three APCs
Macs - dendritic cell - B cell
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Opsonization - neutralization and complement activation
Innate

36. which areas of the body are drained by the celiac lymph node?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG
Steroid - responsive nephrotic syndrome
Stomach

37. What are the two signals in cytotoxic T cells activation?
CD21
Sjorgen's syndrome
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

38. Deficiency in DAF
IgM
IgA
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgG

39. Defect in DNA repair enzymes
Ataxia telangectasia
MHC I
Pernicious anemia (to B12 def) - hashimotos thyroiditis
DM type 1

40. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
Corticomedullary junction
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Major shift minor drift

41. What is the arthus rxn?
Hemochromocytosis
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

42. antismooth muscle
Autoimmune hepatitis
IL-4 - 5 - 10
Bruton's agamma
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

43. anti U1 RNP
RA
Mixed connective tissue disease
Stomach
IL-12 - IFN- beta. IFN- alpha

44. antimicrosomal - antithyroglobulin
Hashimotos
Secondary
Autoimmune hepatitis
Opsonization - neutralization and complement activation

45. What kind of hypersens rxn in anaphylaxis
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Mixed connective tissue disease
I
III

46. How many signals are required for T cell activation or B cell class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
2
IgG - IgM GM makes classic cars
Ceilac disase

47. What do you find in the medulla of the thymus?
IgG
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IFN gamma
III

48. Which is the receptors for EBV?
Corticomedullary junction
CD21
SLE - nonspecific
IL-10

49. What cytokines to Th2 cells secrete?
Goodpastures
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
DM type 1
IL-4 - 5 - 10

50. Where do positive and negative selection occur in the thymus?
IgG
IgG
Corticomedullary junction
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM