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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which MHC complex to CD8 cells bind
Selective Ig def - IgA most common
Graves' dz
MHC I
IL-2 and IFN gamma

2. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
Macs - dendritic cell - B cell
IgM and IgD
Ceilac disase

3. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
IV
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Mature t cells - epithelial reticular cells - Hassalls corpuscles

4. HLA- B27

5. What does a deficiency in C1 esterase inhibitor lead to?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IgM
Hereditary angioedema
Corticomedullary junction

6. Which parts of the antibody to heavy chain contribute?
Fc and Fab
Mesenchyme
II
Perforin - granzyme - granulysin

7. Which parasites exhibit antigenic variation
Corticomedullary junction
Trypanosomes - programmed rearrangement
SCID
IL-12

8. Where is MHC II expressed and and which HLA molecules codes for it
IL-10
APCs - and DR - DP and DQ
Fc and Fab
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

9. HLA- DR7
IgA
Steroid - responsive nephrotic syndrome
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Chronic: fibrosis of graft tissue and blood vessels

10. Which immunoglobulin is a pentamer
CD8 cells
Common variable immunodeficiency (CVID)
Poly/dermato myositis
IgM

11. HLA- D2

12. Defect in DNA repair enzymes
Common variable immunodeficiency (CVID)
CD14
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Ataxia telangectasia

13. What happens in the follicle of the lymph node
PMNs recruited by IL-8 to clear infxns
Ceilac disase
B cell localization and proliferation
Prevents attachment of bacteria and viruses to mucous membranes

14. What is the main function of IgA
PMNs recruited by IL-8 to clear infxns
Chediak Higashi
Prevents attachment of bacteria and viruses to mucous membranes
B cell localization and proliferation

15. What embryologic tissue are lymphcytes derived from
Mesenchyme
Hyperacute : occlusion - ischemia - necrosis
Chronic mucocutaneaous candidiasis
Neisseria bacteremia

16. Cell surface receptors on T cells
Mesenchyme
Steroid - responsive nephrotic syndrome
Autoimmune hepatitis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

17. What is the arthus rxn?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Trypanosomes - programmed rearrangement
Steroid - responsive nephrotic syndrome

18. Antimitochondrial
SLE - nonspecific
Right arm and right half of head
Primary biliary cirrohosis
Il -4

19. Which type of hypersens rxn is serum sickness?
IgM and IgD
DiGeorge
III
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

20. anti glutamate decarboxylase
DM type 1
Pemphigus vulgaris
Mixed connective tissue disease
Chronic: fibrosis of graft tissue and blood vessels

21. Which infections require administering passive immunity?
MS - hay fever - SLE - goodpasture's
IL-12
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Adaptive

22. Defect in B cell maturation
Common variable immunodeficiency (CVID)
IgM and IgD
Chronic mucocutaneaous candidiasis
Pemphigus vulgaris

23. What do you find in the medulla of the thymus?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgG
IgA
IL-12 - IFN- beta. IFN- alpha

24. Which antibody mediates a type Hypersens rxn?
Superficial inguinal pectinate line
Selective Ig def - IgA most common
Goodpastures
IgE

25. Anti ds DNA - anti Smith
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
C5b -9
Innate
SLE

26. Which areas of the body are drained by the axillary lymph node
I
Ataxia telangectasia
Trypanosomes - programmed rearrangement
Upper limb and breast

27. Which cell mediates the type IV hypersens rxn?
IgG
CD8 cells
MHC II 4 x 2=8
SLE - nonspecific

28. antidesmoglein
Pemphigus vulgaris
APCs - and DR - DP and DQ
C5b -9
Selective Ig def - IgA most common

29. Transplant rejection: preformed host antibody mediated
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Hyperacute : occlusion - ischemia - necrosis
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IL-4 - 5 - 10

30. HLA- DR5
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Fc and Fab
IgM
CD14

31. What are the two signals in helper T activation?
Fc and Fab
Signal 1 = APC - signal 2 = B7 and CD28
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Common variable immunodeficiency (CVID)

32. Which B T cell interaction allows for immunologic memory and class switching?
DiGeorge
Bruton's agamma
CD40 and CD40L
MHC I

33. antimicrosomal - antithyroglobulin
SLE
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hashimotos
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

34. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Goodpastures
DiGeorge
No - peptides only can can be presented on MHC molecules
Prevents attachment of bacteria and viruses to mucous membranes

35. What is the unique cell marker for NK cells
IL-12 - IFN- beta. IFN- alpha
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Drug induced lupus
CD56

36. Which antibody (IgM or IgG) crosses the placenta?
C3b
III
Primary biliary cirrohosis
IgG

37. decreased Th1 response
Upper limb and breast
Hyper IgE syndrome (Job's)
IL-12 def
Help B cells make antibody - secrete IFN gamma to activate macs

38. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
CD14
Fab
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

39. p - ANCA
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Other vasculitidies
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IL-12 - IFN- beta. IFN- alpha

40. Which MHC complex to CD4 cells bind
IgM and IgD
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
MHC II 4 x 2=8
Superficial inguinal pectinate line

41. What does HOT- T- Bone stEAk stand for?
C3b
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Hyper IgM

42. Which parts of the antibody to light chain contribute
Fab
IL-12 - IFN- beta. IFN- alpha
CD8 cells
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

43. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
RA - DM type 1
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
CD8 cells

44. c - ANCA
MS - hay fever - SLE - goodpasture's
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Wegeners granulomatosis

45. Which antibody mediates type II and type III hypersens rxn
Right arm and right half of head
CD14
IgG
IgE

46. What are the 4 T's of type IV hypersense
Stomach
Upper limb and breast
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
SLE - nonspecific

47. Which type of hypersens rxn is the arthus rxn
PMNs recruited by IL-8 to clear infxns
Bruton's agamma
III
Fab

48. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Regulates the humoral response
Macs - dendritic cell - B cell
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

49. HLA- DR4
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Major shift minor drift
RA - DM type 1
Other vasculitidies

50. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Adaptive
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Chediak Higashi