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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. thwat does the Right lymphatic duct drain?
S. aureus and S. pyogenes
Right arm and right half of head
IL-12
IL-2 and IFN gamma

2. X- linked recessive defect with progessive deletion of B and T cells
Corticomedullary junction
Scleroderma diffuse
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Pemphigus vulgaris

3. Anticentromere
All nucleated cells (no RBCs) A - B - C
III
Scleroderma CREST
Goodpastures

4. Which antibody mediates type II and type III hypersens rxn
CD40 and CD40L
IgG
IgM and IgD
Howell - Jolly bodies - Target cells - thrombocytosis

5. What are the two signals required for B cells class switching?
DM type 1
CD56
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Chronic mucocutaneaous candidiasis

6. What do mature B lymphos express on their surface?
IgM and IgD
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Graves' dz
SCID

7. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Pernicious anemia (to B12 def) - hashimotos thyroiditis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

8. Which complement proteins make up the MAC
Sjorgen's syndrome
C5b -9
C3b
Innate

9. which areas of the body are drained by the celiac lymph node?
IL-12 def
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Wegeners granulomatosis
Stomach

10. What is the main function of IgA
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Prevents attachment of bacteria and viruses to mucous membranes
Sjorgen's syndrome
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

11. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Chronic granulomatous disease
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IgM and IgD
Fc and Fab

12. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Other vasculitidies
CD40 and CD40L
Primary biliary cirrohosis
IgA

13. Which receptor on MACS to endotoxin directy stimulate?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
No - peptides only can can be presented on MHC molecules
CD14
IL-12 - IFN- beta. IFN- alpha

14. anti basement membrane
Paracortex
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Goodpastures
PMNs recruited by IL-8 to clear infxns

15. Anti - IgG (RF)
Perforin - granzyme - granulysin
Sjorgen's syndrome
Primary biliary cirrohosis
RA

16. What is the clinical picture for serum sickness?
CD40 and CD40L
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Signal 1 = APC - signal 2 = B7 and CD28

17. Th cells don't produce IFN gamma - no PMN response

18. Which infections require administering passive immunity?
IV
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Leukocyte adhesion deficiency type 1
Right arm and right half of head

19. antidesmoglein
Hyper IgE syndrome (Job's)
Pemphigus vulgaris
Stomach
III

20. antigliadin - antiendomysial
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Scleroderma CREST
Graves' dz
Ceilac disase

21. What are the two signals in cytotoxic T cells activation?
Wegeners granulomatosis
III
All nucleated cells (no RBCs) A - B - C
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

22. T cell dysfunction
Chronic mucocutaneaous candidiasis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Hyper IgE syndrome (Job's)
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

23. Which areas of the body are drained by the axillary lymph node
Fc and Fab
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
MHC II 4 x 2=8
Upper limb and breast

24. Defect in B cell maturation
Common variable immunodeficiency (CVID)
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
C5b -9
Secondary

25. Antimitochondrial
Perforin - granzyme - granulysin
IFN gamma
Pemphigus vulgaris
Primary biliary cirrohosis

26. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
III
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

27. Antihistone
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Drug induced lupus
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
B cell localization and proliferation

28. Which immunoglobulin is a pentamer
IgG - IgM GM makes classic cars
Mixed connective tissue disease
IgM
Howell - Jolly bodies - Target cells - thrombocytosis

29. How are NK cells stimulated?
Hemochromocytosis
PMNs recruited by IL-8 to clear infxns
IL-12 - IFN- beta. IFN- alpha
SCID

30. Which parts of the antibody to heavy chain contribute?
Fc and Fab
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

31. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Superficial inguinal pectinate line
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Chediak Higashi

32. Which antibodies activate the classic pathway
Chronic mucocutaneaous candidiasis
Regulates the humoral response
IgM and IgD
IgG - IgM GM makes classic cars

33. HLA- DR7
Steroid - responsive nephrotic syndrome
DM type 1
Perforin - granzyme - granulysin
Pernicious anemia (to B12 def) - hashimotos thyroiditis

34. Which area of the lymph node englarges in an extreme immune response
Paracortex
IL-10
Fab
Chronic: fibrosis of graft tissue and blood vessels

35. Which kind of immunity is germline encoded?
APCs - and DR - DP and DQ
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Hereditary angioedema
Innate

36. Which MHC complex to CD4 cells bind
C5b -9
MHC II 4 x 2=8
SCID
Pernicious anemia (to B12 def) - hashimotos thyroiditis

37. which follicles (primary or secondary) have active germinal centers?
C5b -9
Ataxia telangectasia
Drug induced lupus
Secondary

38. Which type of hypersens rxn is antibody mediated?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
DiGeorge
II
APCs - and DR - DP and DQ

39. What are the 3 funxtions of antibodies?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
MHC I
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Opsonization - neutralization and complement activation

40. Which cell mediates the type IV hypersens rxn?
CD8 cells
Upper limb and breast
Signal 1 = APC - signal 2 = B7 and CD28
Neisseria bacteremia

41. HLA- DR4
IgA
RA - DM type 1
Trypanosomes - programmed rearrangement
APCs - and DR - DP and DQ

42. HLA- DR3
Corticomedullary junction
DM type 1
Wegeners granulomatosis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

43. What does a deficiency in C5- C8 lead to?
Hyperacute : occlusion - ischemia - necrosis
Howell - Jolly bodies - Target cells - thrombocytosis
Neisseria bacteremia
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

44. What happens in the follicle of the lymph node
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Scleroderma diffuse
Corticomedullary junction
B cell localization and proliferation

45. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Autoimmune hepatitis
Hashimotos
Adaptive
RA - DM type 1

46. Which type of hypersens rxn is the arthus rxn
Regulates the humoral response
III
Help B cells make antibody - secrete IFN gamma to activate macs
IgM

47. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Macs - dendritic cell - B cell
Help B cells make antibody - secrete IFN gamma to activate macs
Pernicious anemia (to B12 def) - hashimotos thyroiditis

48. What does clean up on Aisle 8 stand for?
Pemphigus vulgaris
CD21
Common variable immunodeficiency (CVID)
PMNs recruited by IL-8 to clear infxns

49. Where do positive and negative selection occur in the thymus?
Neisseria bacteremia
Drug induced lupus
Corticomedullary junction
Macs - dendritic cell - B cell

50. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
IV
IgE
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant