Test your basic knowledge |

Immunology

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Where do positive and negative selection occur in the thymus?
IV
Graves' dz
Hyper IgM
Corticomedullary junction

2. Where is MHC II expressed and and which HLA molecules codes for it
Help B cells make antibody - secrete IFN gamma to activate macs
Upper limb and breast
APCs - and DR - DP and DQ
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

3. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Scleroderma diffuse
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
2

4. Transplant rejection: preformed host antibody mediated
B cell localization and proliferation
Goodpastures
Hyperacute : occlusion - ischemia - necrosis
Leukocyte adhesion deficiency type 1

5. Which kind of immunity is germline encoded?
Adaptive
Mesenchyme
Innate
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

6. Th cells don't produce IFN gamma - no PMN response

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

7. Which type of hypersens rxn is serum sickness?
IL-12 def
IgM and IgD
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
III

8. What does the Th2 response do?
Regulates the humoral response
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Corticomedullary junction

9. Where is MHC I expressed - and which HLA molecules code for it
Chronic: fibrosis of graft tissue and blood vessels
All nucleated cells (no RBCs) A - B - C
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
SLE

10. antigliadin - antiendomysial
Everything else - not right arm and right half of head
CD14
CD21
Ceilac disase

11. What are the classic example of bacterial antigen variation and the unique mechanims
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Wegeners granulomatosis
Hashimotos
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

12. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
S. aureus and S. pyogenes

13. What are the cell surface receptors on MACS
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Perforin - granzyme - granulysin
Graves' dz
SLE

14. Which cell mediates the type IV hypersens rxn?
Upper limb and breast
Help B cells make antibody - secrete IFN gamma to activate macs
CD8 cells
Stomach

15. How do CD8 cells kill?
Perforin - granzyme - granulysin
Primary biliary cirrohosis
DiGeorge
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

16. which kind of immunity is characterized by receptors that undergo VDJ recombination?
DiGeorge
Perforin - granzyme - granulysin
Hyper IgM
Adaptive

17. What is the difference in antigenic variation in viruses
Macs - dendritic cell - B cell
Chronic granulomatous disease
Major shift minor drift
Secondary

18. What is the clinical picture for serum sickness?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Drug induced lupus
Regulates the humoral response
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

19. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Ataxia telangectasia
Chronic granulomatous disease

20. What is the role of CD4 cels
Hyper IgM
Il -4
Help B cells make antibody - secrete IFN gamma to activate macs
III

21. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
All nucleated cells (no RBCs) A - B - C
Fab
B cell localization and proliferation
SCID

22. Which areas of the body are drained by the axillary lymph node
Ceilac disase
Upper limb and breast
Paracortex
IL-4 - 5 - 10

23. What is the arthus rxn?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Adaptive
IgG
Leukocyte adhesion deficiency type 1

24. Deficiency in DAF
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgE
Perforin - granzyme - granulysin

25. HLA- D2

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

26. Which bacteria secrete superantigen
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Trypanosomes - programmed rearrangement
S. aureus and S. pyogenes
IgG

27. What are the three APCs
Drug induced lupus
Steroid - responsive nephrotic syndrome
Regulates the humoral response
Macs - dendritic cell - B cell

28. antismooth muscle
Autoimmune hepatitis
DM type 1
Ceilac disase
Howell - Jolly bodies - Target cells - thrombocytosis

29. Which antibody mediates a type Hypersens rxn?
Pemphigus vulgaris
IgE
Chediak Higashi
DM type 1

30. Defect in LFA-1 integrin CD18 protein on phagocytes
Mixed connective tissue disease
IgA
Leukocyte adhesion deficiency type 1
Graves' dz

31. Anti Scl 70 (DNA topo I
No - peptides only can can be presented on MHC molecules
Scleroderma diffuse
MHC I
Hyper IgE syndrome (Job's)

32. Cell surface receptors on T cells
DM type 1
Neisseria bacteremia
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Chronic: fibrosis of graft tissue and blood vessels

33. T cell dysfunction
CD21
APCs - and DR - DP and DQ
Chronic mucocutaneaous candidiasis
C5b -9

34. Which complement protein opsonizes bacteria?
C5b -9
C3b
Corticomedullary junction
Chediak Higashi

35. Which parasites exhibit antigenic variation
IL-10
Selective Ig def - IgA most common
Opsonization - neutralization and complement activation
Trypanosomes - programmed rearrangement

36. antimicrosomal - antithyroglobulin
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Poly/dermato myositis
Hashimotos
2

37. What does a deficiency in C3 lead to...
Fc and Fab
Hyper IgM
Hashimotos
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

38. decreased Th1 response
Hashimotos
IL-12 def
Goodpastures
Everything else - not right arm and right half of head

39. Anti ds DNA - anti Smith
SLE
IV
Stomach
CD40 and CD40L

40. What kind of hypersens rxn in anaphylaxis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Other vasculitidies
I
Neisseria bacteremia

41. Which MHC complex to CD8 cells bind
IFN gamma
Steroid - responsive nephrotic syndrome
MHC I
IgG

42. Defectin in isotype switching
Selective Ig def - IgA most common
Chronic granulomatous disease
Poly/dermato myositis
B cell localization and proliferation

43. HLA- DR7
Steroid - responsive nephrotic syndrome
IFN gamma
C5b -9
IgM and IgD

44. What do you find in the medulla of the thymus?
Paracortex
Hyper IgE syndrome (Job's)
Mature t cells - epithelial reticular cells - Hassalls corpuscles
No - peptides only can can be presented on MHC molecules

45. Which is the most abundant immunoglobulin in the blood?
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Upper limb and breast
IgG
Chediak Higashi

46. What interferes with viruses?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Primary biliary cirrohosis
APCs - and DR - DP and DQ
Goodpastures

47. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
IgA
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
DM type 1
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

48. Anti - IgG (RF)
DiGeorge
Drug induced lupus
RA
Signal 1 = APC - signal 2 = B7 and CD28

49. What do mature B lymphos express on their surface?
IL-12 def
Fc
APCs - and DR - DP and DQ
IgM and IgD

50. What does HOT- T- Bone stEAk stand for?
Selective Ig def - IgA most common
Major shift minor drift
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgG - IgM GM makes classic cars