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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What do you find in the medulla of the thymus?
Fab
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
DM type 1

2. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
Common variable immunodeficiency (CVID)
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

3. Which areas of the body are drained by the axillary lymph node
Selective Ig def - IgA most common
III
Upper limb and breast
Trypanosomes - programmed rearrangement

4. What is the difference in antigenic variation in viruses
Major shift minor drift
IgG
MS - hay fever - SLE - goodpasture's
Chronic mucocutaneaous candidiasis

5. Which complement protein opsonizes bacteria?
C3b
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Chediak Higashi
Upper limb and breast

6. Defectin in isotype switching
Upper limb and breast
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Selective Ig def - IgA most common
Leukocyte adhesion deficiency type 1

7. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Pemphigus vulgaris
IgG
Fc
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

8. How are NK cells stimulated?
Steroid - responsive nephrotic syndrome
IL-12 - IFN- beta. IFN- alpha
RA - DM type 1
MS - hay fever - SLE - goodpasture's

9. anti glutamate decarboxylase
Fc
Everything else - not right arm and right half of head
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
DM type 1

10. antidesmoglein
Graves' dz
Pemphigus vulgaris
2
Drug induced lupus

11. ANA
Scleroderma CREST
Neisseria bacteremia
Superficial inguinal pectinate line
SLE - nonspecific

12. HLA- A3
Hemochromocytosis
Ataxia telangectasia
Perforin - granzyme - granulysin
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

13. What are the 3 funxtions of antibodies?
Scleroderma CREST
Opsonization - neutralization and complement activation
III
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

14. Anti ds DNA - anti Smith
DiGeorge
Ataxia telangectasia
SLE
Sjorgen's syndrome

15. Which MHC complex to CD8 cells bind
MHC I
MHC II 4 x 2=8
APCs - and DR - DP and DQ
Steroid - responsive nephrotic syndrome

16. What are the classic example of bacterial antigen variation and the unique mechanims
IgA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
C5b -9

17. What does HOT- T- Bone stEAk stand for?
Poly/dermato myositis
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Upper limb and breast
Right arm and right half of head

18. Which complement proteins make up the MAC
C5b -9
Ataxia telangectasia
Stomach
SLE

19. What embryologic tissue are lymphcytes derived from
Fc and Fab
Mesenchyme
Neisseria bacteremia
Goodpastures

20. HLA- DR3
DM type 1
Opsonization - neutralization and complement activation
IgG
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

21. Which bacteria secrete superantigen
III
IL-2 and IFN gamma
III
S. aureus and S. pyogenes

22. Where is MHC II expressed and and which HLA molecules codes for it
CD14
APCs - and DR - DP and DQ
Hereditary angioedema
Scleroderma diffuse

23. Th cells don't produce IFN gamma - no PMN response

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24. What inhibits Th2 cells
Poly/dermato myositis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Innate
IFN gamma

25. Defect in B cell maturation
RA
Common variable immunodeficiency (CVID)
Fc and Fab
Chediak Higashi

26. X- linked recessive defect with progessive deletion of B and T cells
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IgA
Hyperacute : occlusion - ischemia - necrosis

27. Which cytokine induces Th2 cell profile in CD4 cells
Chronic: fibrosis of graft tissue and blood vessels
Il -4
MS - hay fever - SLE - goodpasture's
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

28. Which infections require administering passive immunity?
CD8 cells
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
CD40 and CD40L

29. How many signals are required for T cell activation or B cell class switching?
Prevents attachment of bacteria and viruses to mucous membranes
2
Pemphigus vulgaris
Howell - Jolly bodies - Target cells - thrombocytosis

30. What do superantigens do?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
II
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Ataxia telangectasia

31. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
C3b
Chronic mucocutaneaous candidiasis
Chronic granulomatous disease

32. Which is the most abundant immunoglobulin in the blood?
Mixed connective tissue disease
Major shift minor drift
IgG
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

33. What are the cell surface receptors on MACS
Howell - Jolly bodies - Target cells - thrombocytosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Mesenchyme
Trypanosomes - programmed rearrangement

34. What does the Th2 response do?
MHC I
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Regulates the humoral response
DM type 1

35. What interferes with viruses?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
II
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

36. antigliadin - antiendomysial
Ceilac disase
Right arm and right half of head
DiGeorge
Chediak Higashi

37. AR - defect in microtubule fxn with decreased phagocytosis
Primary biliary cirrohosis
Secondary
Chediak Higashi
All nucleated cells (no RBCs) A - B - C

38. antismooth muscle
Fab
IL-12
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Autoimmune hepatitis

39. What kind of bacteria do macrophages remove from the spleen?
Stomach
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Trypanosomes - programmed rearrangement

40. What is the arthus rxn?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IL-12 - IFN- beta. IFN- alpha
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

41. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
SLE - nonspecific
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

42. Anti - IgG (RF)
IFN gamma
Corticomedullary junction
Sjorgen's syndrome
RA

43. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
DM type 1
Hyper IgE syndrome (Job's)
Macs - dendritic cell - B cell

44. Antihistone
Drug induced lupus
III
CD21
Hyper IgE syndrome (Job's)

45. Transplant rejection: preformed host antibody mediated
DM type 1
Secondary
Hyperacute : occlusion - ischemia - necrosis
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

46. Which antibody (IgM or IgG) crosses the placenta?
Pemphigus vulgaris
IgG
MHC I
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

47. Defect in LFA-1 integrin CD18 protein on phagocytes
Fc
IL-2 and IFN gamma
DM type 1
Leukocyte adhesion deficiency type 1

48. HLA- DR5
CD14
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Superficial inguinal pectinate line
IgE

49. Which cell mediates the type IV hypersens rxn?
CD8 cells
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Help B cells make antibody - secrete IFN gamma to activate macs

50. Defect in CD40L on helper T
Everything else - not right arm and right half of head
IgM
III
Hyper IgM