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Test your basic knowledge |
Immunology
Start Test
Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the three things you find post splenectomy
IgM
IgG
Howell - Jolly bodies - Target cells - thrombocytosis
IgM and IgD
2. Which B T cell interaction allows for immunologic memory and class switching?
Selective Ig def - IgA most common
CD40 and CD40L
Steroid - responsive nephrotic syndrome
S. aureus and S. pyogenes
3. anti U1 RNP
PMNs recruited by IL-8 to clear infxns
Paracortex
SLE - nonspecific
Mixed connective tissue disease
4. decreased Th1 response
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IL-12 def
Macs - dendritic cell - B cell
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
5. c - ANCA
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Mesenchyme
Chronic mucocutaneaous candidiasis
Wegeners granulomatosis
6. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
CD14
Hyperacute : occlusion - ischemia - necrosis
Il -4
SCID
7. which follicles (primary or secondary) have active germinal centers?
Secondary
Hyperacute : occlusion - ischemia - necrosis
Hyper IgM
Prevents attachment of bacteria and viruses to mucous membranes
8. What are the 4 T's of type IV hypersense
Macs - dendritic cell - B cell
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Autoimmune hepatitis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
9. Transplant rejection: preformed host antibody mediated
Hyperacute : occlusion - ischemia - necrosis
Fc and Fab
IL-4 - 5 - 10
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
10. What inhibits Th2 cells
IFN gamma
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Prevents attachment of bacteria and viruses to mucous membranes
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
11. Which antibodies activate the classic pathway
SCID
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgG - IgM GM makes classic cars
RA - DM type 1
12. What are the classic example of bacterial antigen variation and the unique mechanims
Mixed connective tissue disease
Goodpastures
Adaptive
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
13. Anti ds DNA - anti Smith
Mature t cells - epithelial reticular cells - Hassalls corpuscles
C3b
Chronic: fibrosis of graft tissue and blood vessels
SLE
14. Defect in DNA repair enzymes
Ataxia telangectasia
SCID
Primary biliary cirrohosis
Ceilac disase
15. Which cytokine induces Th2 cell profile in CD4 cells
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Il -4
IgM
I
16. How do NK cells kill?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Opsonization - neutralization and complement activation
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
17. transplant rejection: T cell and antibody mediated vasular damage
Macs - dendritic cell - B cell
Mesenchyme
Chronic: fibrosis of graft tissue and blood vessels
Chediak Higashi
18. Defect in LFA-1 integrin CD18 protein on phagocytes
MHC I
Leukocyte adhesion deficiency type 1
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
19. Which antibody mediates type II and type III hypersens rxn
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgG
Pernicious anemia (to B12 def) - hashimotos thyroiditis
MHC I
20. Where is MHC I expressed - and which HLA molecules code for it
Fc and Fab
DiGeorge
Scleroderma CREST
All nucleated cells (no RBCs) A - B - C
21. Which antibody (IgM or IgG) crosses the placenta?
Poly/dermato myositis
IgG
Corticomedullary junction
Everything else - not right arm and right half of head
22. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
Primary biliary cirrohosis
DiGeorge
C5b -9
23. How many signals are required for T cell activation or B cell class switching?
2
IgG - IgM GM makes classic cars
CD56
Chronic: fibrosis of graft tissue and blood vessels
24. Th cells don't produce IFN gamma - no PMN response
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25. Where is MHC II expressed and and which HLA molecules codes for it
Sjorgen's syndrome
Stomach
Other vasculitidies
APCs - and DR - DP and DQ
26. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
Primary biliary cirrohosis
IgG
Chediak Higashi
27. Which cytokine induces Th1 cell profile in CD4 cells
Chronic mucocutaneaous candidiasis
Adaptive
III
IL-12
28. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Regulates the humoral response
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
S. aureus and S. pyogenes
29. What interferes with viruses?
Fc and Fab
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
SCID
IgG
30. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
DiGeorge
III
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
31. Which receptor on MACS to endotoxin directy stimulate?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
CD8 cells
CD14
Adaptive
32. Which type of hypersens rxn is serum sickness?
SLE
CD8 cells
Fc
III
33. Which complement proteins make up the MAC
C5b -9
IL-12 - IFN- beta. IFN- alpha
Common variable immunodeficiency (CVID)
III
34. What kind of bacteria do macrophages remove from the spleen?
Chronic: fibrosis of graft tissue and blood vessels
Fc
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
CD40 and CD40L
35. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
B cell localization and proliferation
IL-2 and IFN gamma
Stomach
36. Which parts of the antibody to heavy chain contribute?
Steroid - responsive nephrotic syndrome
Fc and Fab
SLE
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
37. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
Help B cells make antibody - secrete IFN gamma to activate macs
Innate
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
38. What is the unique cell marker for NK cells
Regulates the humoral response
CD56
IgG - IgM GM makes classic cars
Poly/dermato myositis
39. What does the Th2 response do?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Regulates the humoral response
IL-12 - IFN- beta. IFN- alpha
40. X- linked recessive defect with progessive deletion of B and T cells
2
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Pernicious anemia (to B12 def) - hashimotos thyroiditis
B cell localization and proliferation
41. Which complement protein opsonizes bacteria?
C3b
I
S. aureus and S. pyogenes
Scleroderma diffuse
42. Defectin in isotype switching
Fc and Fab
Neisseria bacteremia
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Selective Ig def - IgA most common
43. Cell surface receptors on B cels
III
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Ceilac disase
44. What kind of hypersens rxn in anaphylaxis
IgG
IgM and IgD
I
Hashimotos
45. What is the clinical picture for serum sickness?
Hyper IgE syndrome (Job's)
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
46. Which MHC complex to CD8 cells bind
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IL-2 and IFN gamma
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
MHC I
47. What happens in the follicle of the lymph node
B cell localization and proliferation
CD14
IL-4 - 5 - 10
Fc
48. Where do positive and negative selection occur in the thymus?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Corticomedullary junction
Sjorgen's syndrome
MHC II 4 x 2=8
49. Which antibody mediates a type Hypersens rxn?
DiGeorge
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Right arm and right half of head
IgE
50. What embryologic tissue are lymphcytes derived from
APCs - and DR - DP and DQ
Mesenchyme
IL-12
All nucleated cells (no RBCs) A - B - C