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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which parts of the antibody to light chain contribute
Sjorgen's syndrome
IL-4 - 5 - 10
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Fab

2. Antihistone
Common variable immunodeficiency (CVID)
Other vasculitidies
Drug induced lupus
Chronic mucocutaneaous candidiasis

3. Which receptor on MACS to endotoxin directy stimulate?
CD14
RA - DM type 1
Goodpastures
IgM and IgD

4. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
Perforin - granzyme - granulysin
CD56
IL-12

5. Which MHC complex to CD8 cells bind
MHC I
Fc and Fab
All nucleated cells (no RBCs) A - B - C
SLE

6. ANA
CD21
SLE - nonspecific
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-12 - IFN- beta. IFN- alpha

7. anti - Jo 1
Poly/dermato myositis
RA
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

8. What kind of hypersens rxn in anaphylaxis
DiGeorge
I
IgG - IgM GM makes classic cars
Macs - dendritic cell - B cell

9. What are the cytokines involved in macrophage/lymphocyte interaction
IgG
MHC I
SLE - nonspecific
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

10. Where is MHC I expressed - and which HLA molecules code for it
IgM
All nucleated cells (no RBCs) A - B - C
Help B cells make antibody - secrete IFN gamma to activate macs
Secondary

11. Transplant rejection: preformed host antibody mediated
B cell localization and proliferation
IL-12
Hyperacute : occlusion - ischemia - necrosis
Paracortex

12. Anticentromere
MHC I
Scleroderma CREST
IFN gamma
B cell localization and proliferation

13. antigliadin - antiendomysial
Ceilac disase
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Right arm and right half of head
SCID

14. anti glutamate decarboxylase
Chronic granulomatous disease
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
DM type 1
Hashimotos

15. which follicles (primary or secondary) have active germinal centers?
Chronic granulomatous disease
Secondary
CD14
I

16. What inhibits Th2 cells
IgG
IFN gamma
No - peptides only can can be presented on MHC molecules
Upper limb and breast

17. anti SS A/B or anti Ro/La

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18. Which cell mediates the type IV hypersens rxn?
Neisseria bacteremia
IL-10
III
CD8 cells

19. What are the two signals required for B cells class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
S. aureus and S. pyogenes
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

20. What are the 3 funxtions of antibodies?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgE
Opsonization - neutralization and complement activation
CD14

21. Which antibody mediates type II and type III hypersens rxn
SLE
Autoimmune hepatitis
Paracortex
IgG

22. How many signals are required for T cell activation or B cell class switching?
Prevents attachment of bacteria and viruses to mucous membranes
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG
2

23. Which cytokines to Th1 cells secrete?
Corticomedullary junction
Selective Ig def - IgA most common
IL-2 and IFN gamma
Upper limb and breast

24. Which is the receptors for EBV?
CD21
Right arm and right half of head
IL-12 - IFN- beta. IFN- alpha
IgG - IgM GM makes classic cars

25. Which B T cell interaction allows for immunologic memory and class switching?
Scleroderma CREST
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
CD40 and CD40L
IgA

26. What cytokines to Th2 cells secrete?
Opsonization - neutralization and complement activation
Selective Ig def - IgA most common
IL-4 - 5 - 10
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

27. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
SCID
Hyperacute : occlusion - ischemia - necrosis

28. Which kind of immunity is germline encoded?
Drug induced lupus
IgE
Innate
No - peptides only can can be presented on MHC molecules

29. HLA- A3
Hemochromocytosis
MHC I
Everything else - not right arm and right half of head
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

30. Defect in DNA repair enzymes
IV
Selective Ig def - IgA most common
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Ataxia telangectasia

31. What is the role of CD4 cels
CD14
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD21
Help B cells make antibody - secrete IFN gamma to activate macs

32. HLA- D2

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33. Which parasites exhibit antigenic variation
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Trypanosomes - programmed rearrangement
Fab
CD40 and CD40L

34. What do superantigens do?
Perforin - granzyme - granulysin
Howell - Jolly bodies - Target cells - thrombocytosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IgG

35. transplant rejection: T cell and antibody mediated vasular damage
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
I
CD14
Chronic: fibrosis of graft tissue and blood vessels

36. What does the Th2 response do?
Regulates the humoral response
IL-12
IgG - IgM GM makes classic cars
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

37. HLA- DR5
RA
Macs - dendritic cell - B cell
Steroid - responsive nephrotic syndrome
Pernicious anemia (to B12 def) - hashimotos thyroiditis

38. Cell surface receptors on T cells
DM type 1
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgG
Howell - Jolly bodies - Target cells - thrombocytosis

39. Which type of hypersens rxn is immune complex mediate
MS - hay fever - SLE - goodpasture's
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
III
Selective Ig def - IgA most common

40. What do you find in the medulla of the thymus?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IgM and IgD
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Fc

41. What is the main function of IgA
Everything else - not right arm and right half of head
Mesenchyme
Sjorgen's syndrome
Prevents attachment of bacteria and viruses to mucous membranes

42. Which type of hypersens rxn is antibody mediated?
Chronic granulomatous disease
All nucleated cells (no RBCs) A - B - C
Mesenchyme
II

43. What is the arthus rxn?
Selective Ig def - IgA most common
IL-10
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Prevents attachment of bacteria and viruses to mucous membranes

44. Which cytokine inhibits Th1 cells
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IL-10
III
Neisseria bacteremia

45. Which infections require administering passive immunity?
Everything else - not right arm and right half of head
III
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Ceilac disase

46. What do mature B lymphos express on their surface?
DiGeorge
Mesenchyme
IgM and IgD
Hyperacute : occlusion - ischemia - necrosis

47. X linked recessive defect in BTK no B cell differentiation

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48. Deficiency in DAF
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Hemochromocytosis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Secondary

49. Which type of hypersens rxn is serum sickness?
All nucleated cells (no RBCs) A - B - C
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
III
Superficial inguinal pectinate line

50. decreased Th1 response
IgG
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IL-12 def
Right arm and right half of head