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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which complement protein opsonizes bacteria?
C3b
RA - DM type 1
IL-10
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

2. thwat does the Right lymphatic duct drain?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Right arm and right half of head
Neisseria bacteremia
DM type 1

3. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Primary biliary cirrohosis
Hemochromocytosis
Chronic granulomatous disease
IgM

4. antismooth muscle
SLE
DM type 1
Autoimmune hepatitis
C3b

5. What happens in the follicle of the lymph node
B cell localization and proliferation
Howell - Jolly bodies - Target cells - thrombocytosis
Hemochromocytosis
I

6. What are the two signals required for B cells class switching?
B cell localization and proliferation
I
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Other vasculitidies

7. Which is the most abundant immunoglobulin in the blood?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgG
IgA
Help B cells make antibody - secrete IFN gamma to activate macs

8. Defect in CD40L on helper T
MS - hay fever - SLE - goodpasture's
Hyperacute : occlusion - ischemia - necrosis
IgE
Hyper IgM

9. Which type of hypersens rxn is delayed
IV
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Leukocyte adhesion deficiency type 1
CD14

10. What is the unique cell marker for NK cells
Pernicious anemia (to B12 def) - hashimotos thyroiditis
CD56
Regulates the humoral response
III

11. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
SCID
IgM and IgD
C5b -9

12. Defect in LFA-1 integrin CD18 protein on phagocytes
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Leukocyte adhesion deficiency type 1
Hereditary angioedema
Bruton's agamma

13. Which cell mediates the type IV hypersens rxn?
C5b -9
CD8 cells
III
Chronic mucocutaneaous candidiasis

14. What do mature B lymphos express on their surface?
Superficial inguinal pectinate line
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Trypanosomes - programmed rearrangement
IgM and IgD

15. c - ANCA
IgG
MHC II 4 x 2=8
Wegeners granulomatosis
Secondary

16. HLA- DR7
Scleroderma CREST
Steroid - responsive nephrotic syndrome
Goodpastures
DiGeorge

17. What is the clinical picture for serum sickness?
Regulates the humoral response
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Graves' dz

18. transplant rejection: T cell and antibody mediated vasular damage
Pemphigus vulgaris
Common variable immunodeficiency (CVID)
IgA
Chronic: fibrosis of graft tissue and blood vessels

19. Anti Scl 70 (DNA topo I
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
MS - hay fever - SLE - goodpasture's
Scleroderma diffuse
Ataxia telangectasia

20. What are the two signals in cytotoxic T cells activation?
MS - hay fever - SLE - goodpasture's
IL-4 - 5 - 10
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
SLE

21. Which infections require administering passive immunity?
MHC II 4 x 2=8
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
PMNs recruited by IL-8 to clear infxns

22. HLA- DR3
Poly/dermato myositis
Opsonization - neutralization and complement activation
DM type 1
II

23. What does HOT- T- Bone stEAk stand for?
III
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Ceilac disase
IgG

24. What are the classic example of bacterial antigen variation and the unique mechanims
Leukocyte adhesion deficiency type 1
Fc and Fab
RA - DM type 1
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

25. anti basement membrane
Goodpastures
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Howell - Jolly bodies - Target cells - thrombocytosis
Corticomedullary junction

26. What are the cytokines involved in macrophage/lymphocyte interaction
Mesenchyme
MHC I
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

27. What are the three things you find post splenectomy
Howell - Jolly bodies - Target cells - thrombocytosis
Other vasculitidies
Ataxia telangectasia
Signal 1 = APC - signal 2 = B7 and CD28

28. HLA- A3
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
DM type 1
Superficial inguinal pectinate line
Hemochromocytosis

29. Which lymph node drains the anal canal below
Chediak Higashi
Chronic: fibrosis of graft tissue and blood vessels
Hyper IgE syndrome (Job's)
Superficial inguinal pectinate line

30. anti U1 RNP
Mixed connective tissue disease
SLE - nonspecific
Mesenchyme
I

31. What are the two signals in helper T activation?
Howell - Jolly bodies - Target cells - thrombocytosis
Signal 1 = APC - signal 2 = B7 and CD28
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
S. aureus and S. pyogenes

32. How do NK cells kill?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IgM
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Howell - Jolly bodies - Target cells - thrombocytosis

33. Which parts of the antibody to heavy chain contribute?
CD8 cells
Fc and Fab
Hereditary angioedema
I

34. AR - defect in microtubule fxn with decreased phagocytosis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Chediak Higashi
Pemphigus vulgaris
Hyper IgE syndrome (Job's)

35. Which parts of the antibody to light chain contribute
I
Perforin - granzyme - granulysin
2
Fab

36. What are the three APCs
Secondary
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Macs - dendritic cell - B cell
Mixed connective tissue disease

37. What do you find in the medulla of the thymus?
CD56
Macs - dendritic cell - B cell
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

38. Which antibody (IgM or IgG) crosses the placenta?
CD40 and CD40L
IgG
No - peptides only can can be presented on MHC molecules
Mesenchyme

39. Which complement proteins make up the MAC
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IL-2 and IFN gamma
C5b -9
Regulates the humoral response

40. Defect in DNA repair enzymes
Major shift minor drift
C3b
Bruton's agamma
Ataxia telangectasia

41. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
All nucleated cells (no RBCs) A - B - C
Selective Ig def - IgA most common
C5b -9

42. which areas of the body are drained by the celiac lymph node?
DiGeorge
Il -4
Stomach
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

43. Which is the receptors for EBV?
Fc
DM type 1
CD21
Hereditary angioedema

44. What does a deficiency in C1 esterase inhibitor lead to?
Superficial inguinal pectinate line
Hyper IgE syndrome (Job's)
Hereditary angioedema
PMNs recruited by IL-8 to clear infxns

45. anti - Jo 1
Poly/dermato myositis
Pemphigus vulgaris
Neisseria bacteremia
DiGeorge

46. which follicles (primary or secondary) have active germinal centers?
Paracortex
Secondary
CD14
Innate

47. Where is MHC II expressed and and which HLA molecules codes for it
Macs - dendritic cell - B cell
B cell localization and proliferation
APCs - and DR - DP and DQ
III

48. Which cytokine inhibits Th1 cells
IL-10
Mesenchyme
CD56
Perforin - granzyme - granulysin

49. Which B T cell interaction allows for immunologic memory and class switching?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
CD40 and CD40L
IgG
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

50. Which antibody mediates type II and type III hypersens rxn
CD40 and CD40L
IgG
I
Perforin - granzyme - granulysin