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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Anticentromere
IgM and IgD
Chronic: fibrosis of graft tissue and blood vessels
Selective Ig def - IgA most common
Scleroderma CREST

2. Which antibody mediates a type Hypersens rxn?
Mesenchyme
IgG
Primary biliary cirrohosis
IgE

3. HLA- B27

4. antimicrosomal - antithyroglobulin
Chronic mucocutaneaous candidiasis
Innate
Hashimotos
IgG

5. What are the classic example of bacterial antigen variation and the unique mechanims
Fc and Fab
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
CD56
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

6. antidesmoglein
Hyper IgE syndrome (Job's)
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Leukocyte adhesion deficiency type 1
Pemphigus vulgaris

7. HLA- DR4
DiGeorge
RA - DM type 1
Regulates the humoral response
Secondary

8. anti U1 RNP
IgG
Mixed connective tissue disease
Fc and Fab
All nucleated cells (no RBCs) A - B - C

9. What kind of bacteria do macrophages remove from the spleen?
Neisseria bacteremia
Hyper IgM
Common variable immunodeficiency (CVID)
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

10. What do you find in the medulla of the thymus?
Macs - dendritic cell - B cell
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Howell - Jolly bodies - Target cells - thrombocytosis

11. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
IFN gamma
SCID
Neisseria bacteremia
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

12. p - ANCA
Other vasculitidies
DM type 1
Paracortex
RA

13. thwat does the Right lymphatic duct drain?
RA - DM type 1
III
IL-2 and IFN gamma
Right arm and right half of head

14. Which is the most abundant immunoglobulin in the blood?
Other vasculitidies
IV
IgG
Major shift minor drift

15. Which antibodies activate the classic pathway
IL-2 and IFN gamma
IgG - IgM GM makes classic cars
Wegeners granulomatosis
Help B cells make antibody - secrete IFN gamma to activate macs

16. How do CD8 cells kill?
SCID
Fc
Perforin - granzyme - granulysin
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

17. T cell dysfunction
Chronic mucocutaneaous candidiasis
Hyper IgE syndrome (Job's)
Help B cells make antibody - secrete IFN gamma to activate macs
CD8 cells

18. What does the thoracic duct drain?
Everything else - not right arm and right half of head
No - peptides only can can be presented on MHC molecules
Regulates the humoral response
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

19. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

20. How are NK cells stimulated?
Trypanosomes - programmed rearrangement
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-12 - IFN- beta. IFN- alpha
Chediak Higashi

21. What are the two signals required for B cells class switching?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Signal 1 = APC - signal 2 = B7 and CD28
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Macs - dendritic cell - B cell

22. What does HOT- T- Bone stEAk stand for?
Poly/dermato myositis
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IgE

23. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Regulates the humoral response
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

24. What are the 4 T's of type IV hypersense
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgE
C3b
Chronic: fibrosis of graft tissue and blood vessels

25. Which portion of the antibody determines the isotype
Fc
MHC I
Corticomedullary junction
IL-2 and IFN gamma

26. Which type of hypersens rxn is serum sickness?
CD40 and CD40L
C5b -9
III
IL-12 - IFN- beta. IFN- alpha

27. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
Perforin - granzyme - granulysin
S. aureus and S. pyogenes
Hyper IgM

28. Which kind of immunity is germline encoded?
Regulates the humoral response
IgG - IgM GM makes classic cars
Innate
C5b -9

29. What inhibits Th2 cells
I
IFN gamma
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-10

30. What are the three APCs
Macs - dendritic cell - B cell
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Ataxia telangectasia
Sjorgen's syndrome

31. Antimitochondrial
Hyperacute : occlusion - ischemia - necrosis
SLE
Perforin - granzyme - granulysin
Primary biliary cirrohosis

32. Which antibody (IgM or IgG) crosses the placenta?
Scleroderma CREST
Stomach
IgG
Secondary

33. What are the cell surface receptors on MACS
Graves' dz
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
III
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

34. ANA
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
SLE - nonspecific
MHC II 4 x 2=8
Hyper IgE syndrome (Job's)

35. Which cytokine induces Th1 cell profile in CD4 cells
Prevents attachment of bacteria and viruses to mucous membranes
Sjorgen's syndrome
Ceilac disase
IL-12

36. Which cell mediates the type IV hypersens rxn?
CD8 cells
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
DM type 1
SLE

37. What do mature B lymphos express on their surface?
All nucleated cells (no RBCs) A - B - C
Upper limb and breast
CD40 and CD40L
IgM and IgD

38. X linked recessive defect in BTK no B cell differentiation

39. Defect in CD40L on helper T
Paracortex
Hyper IgM
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
C5b -9

40. HLA- DR7
IgE
Corticomedullary junction
Steroid - responsive nephrotic syndrome
IgG

41. What kind of hypersens rxn in anaphylaxis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
I
IL-4 - 5 - 10

42. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Other vasculitidies
B cell localization and proliferation
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

43. Defect in LFA-1 integrin CD18 protein on phagocytes
Leukocyte adhesion deficiency type 1
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
PMNs recruited by IL-8 to clear infxns
Pemphigus vulgaris

44. What are the three things you find post splenectomy
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Ataxia telangectasia
Howell - Jolly bodies - Target cells - thrombocytosis

45. Which parts of the antibody to heavy chain contribute?
Macs - dendritic cell - B cell
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Fc and Fab
Signal 1 = APC - signal 2 = B7 and CD28

46. Which MHC complex to CD8 cells bind
IV
Poly/dermato myositis
MHC I
CD8 cells

47. Antihistone
Drug induced lupus
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Il -4
MS - hay fever - SLE - goodpasture's

48. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
IgG
Regulates the humoral response
DiGeorge
Steroid - responsive nephrotic syndrome

49. c - ANCA
DM type 1
Wegeners granulomatosis
Fc
IFN gamma

50. What happens in the follicle of the lymph node
RA
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
B cell localization and proliferation
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant