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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-2 and IFN gamma
IgG - IgM GM makes classic cars

2. Which parts of the antibody to heavy chain contribute?
Fc and Fab
Stomach
Chediak Higashi
Chronic: fibrosis of graft tissue and blood vessels

3. What is the clinical picture for serum sickness?
Fc and Fab
Stomach
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Other vasculitidies

4. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
IgE
SLE
DiGeorge
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

5. Which antibody (IgM or IgG) crosses the placenta?
Hyper IgE syndrome (Job's)
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IgG - IgM GM makes classic cars
IgG

6. anti basement membrane
Goodpastures
Corticomedullary junction
Adaptive
IgM

7. Which complement proteins make up the MAC
C5b -9
Hyperacute : occlusion - ischemia - necrosis
SLE
Superficial inguinal pectinate line

8. What does the Th2 response do?
Fc and Fab
IgM and IgD
Hyperacute : occlusion - ischemia - necrosis
Regulates the humoral response

9. Which kind of immunity is germline encoded?
Innate
No - peptides only can can be presented on MHC molecules
CD21
IL-12

10. HLA- DR5
Graves' dz
Trypanosomes - programmed rearrangement
IL-12
Pernicious anemia (to B12 def) - hashimotos thyroiditis

11. HLA- B27

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12. What kind of hypersens rxn in anaphylaxis
I
Steroid - responsive nephrotic syndrome
Hereditary angioedema
Chronic mucocutaneaous candidiasis

13. What does a deficiency in C1 esterase inhibitor lead to?
Bruton's agamma
Corticomedullary junction
Hereditary angioedema
Paracortex

14. What is the unique cell marker for NK cells
IL-2 and IFN gamma
CD56
Ceilac disase
Macs - dendritic cell - B cell

15. antismooth muscle
III
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
S. aureus and S. pyogenes
Autoimmune hepatitis

16. AR - defect in microtubule fxn with decreased phagocytosis
Secondary
Chediak Higashi
Opsonization - neutralization and complement activation
Adaptive

17. What is the main function of IgA
Chediak Higashi
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Prevents attachment of bacteria and viruses to mucous membranes
Regulates the humoral response

18. anti glutamate decarboxylase
Mesenchyme
DM type 1
Neisseria bacteremia
IL-10

19. ANA
IgM
SLE - nonspecific
Upper limb and breast
Graves' dz

20. Which B T cell interaction allows for immunologic memory and class switching?
Drug induced lupus
CD40 and CD40L
Prevents attachment of bacteria and viruses to mucous membranes
CD14

21. Which MHC complex to CD8 cells bind
Prevents attachment of bacteria and viruses to mucous membranes
MHC I
IgE
Everything else - not right arm and right half of head

22. How do NK cells kill?
Neisseria bacteremia
Everything else - not right arm and right half of head
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
2

23. Defectin in isotype switching
Fab
Selective Ig def - IgA most common
Macs - dendritic cell - B cell
Mixed connective tissue disease

24. How many signals are required for T cell activation or B cell class switching?
2
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Il -4
Poly/dermato myositis

25. Antimitochondrial
Primary biliary cirrohosis
All nucleated cells (no RBCs) A - B - C
SLE - nonspecific
CD14

26. Cell surface receptors on B cels
CD21
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

27. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Superficial inguinal pectinate line
Fc
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

28. What happens in the follicle of the lymph node
All nucleated cells (no RBCs) A - B - C
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
B cell localization and proliferation

29. Which infections require administering passive immunity?
IL-12 def
Macs - dendritic cell - B cell
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
I

30. How do CD8 cells kill?
IV
C3b
Adaptive
Perforin - granzyme - granulysin

31. thwat does the Right lymphatic duct drain?
Selective Ig def - IgA most common
Leukocyte adhesion deficiency type 1
Right arm and right half of head
CD40 and CD40L

32. What are the two signals in helper T activation?
Goodpastures
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Signal 1 = APC - signal 2 = B7 and CD28
B cell localization and proliferation

33. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
CD40 and CD40L
PMNs recruited by IL-8 to clear infxns
Hereditary angioedema

34. Which type of hypersens rxn is the arthus rxn
Il -4
APCs - and DR - DP and DQ
III
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

35. HLA- D2

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36. What is the arthus rxn?
Scleroderma diffuse
Secondary
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Superficial inguinal pectinate line

37. Which receptor on MACS to endotoxin directy stimulate?
CD14
Corticomedullary junction
IgG
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

38. Which parts of the antibody to light chain contribute
Bruton's agamma
Fab
Superficial inguinal pectinate line
Autoimmune hepatitis

39. What inhibits Th2 cells
IFN gamma
Selective Ig def - IgA most common
SLE
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

40. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Chronic granulomatous disease
Regulates the humoral response
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Macs - dendritic cell - B cell

41. Which area of the lymph node englarges in an extreme immune response
Paracortex
IV
Opsonization - neutralization and complement activation
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

42. HLA- A3
Drug induced lupus
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
DiGeorge
Hemochromocytosis

43. What are the classic example of bacterial antigen variation and the unique mechanims
Fc and Fab
Drug induced lupus
Everything else - not right arm and right half of head
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

44. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
IgG
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Goodpastures
No - peptides only can can be presented on MHC molecules

45. Deficiency in DAF
Common variable immunodeficiency (CVID)
No - peptides only can can be presented on MHC molecules
Chronic granulomatous disease
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

46. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
RA
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IgG

47. What kind of bacteria do macrophages remove from the spleen?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Sjorgen's syndrome
Primary biliary cirrohosis

48. c - ANCA
Wegeners granulomatosis
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Upper limb and breast
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

49. X linked recessive defect in BTK no B cell differentiation

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50. What are the 4 T's of type IV hypersense
PMNs recruited by IL-8 to clear infxns
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-12
Innate