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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which areas of the body are drained by the axillary lymph node
Macs - dendritic cell - B cell
Signal 1 = APC - signal 2 = B7 and CD28
Upper limb and breast
Prevents attachment of bacteria and viruses to mucous membranes

2. anti U1 RNP
Stomach
Trypanosomes - programmed rearrangement
Mixed connective tissue disease
MHC II 4 x 2=8

3. Defect in DNA repair enzymes
Ataxia telangectasia
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Common variable immunodeficiency (CVID)

4. HLA- DR3
DM type 1
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-12
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

5. Which cytokine induces Th2 cell profile in CD4 cells
Drug induced lupus
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Hyper IgE syndrome (Job's)
Il -4

6. Defectin in isotype switching
All nucleated cells (no RBCs) A - B - C
Selective Ig def - IgA most common
Fc and Fab
IL-12

7. Which type of hypersens rxn is immune complex mediate
Perforin - granzyme - granulysin
IL-12
Hyperacute : occlusion - ischemia - necrosis
III

8. antimicrosomal - antithyroglobulin
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Prevents attachment of bacteria and viruses to mucous membranes
Neisseria bacteremia
Hashimotos

9. Which complement proteins make up the MAC
Other vasculitidies
PMNs recruited by IL-8 to clear infxns
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
C5b -9

10. What embryologic tissue are lymphcytes derived from
Mesenchyme
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Common variable immunodeficiency (CVID)

11. Which parts of the antibody to heavy chain contribute?
Signal 1 = APC - signal 2 = B7 and CD28
All nucleated cells (no RBCs) A - B - C
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Fc and Fab

12. Which antibodies activate the classic pathway
C3b
2
III
IgG - IgM GM makes classic cars

13. Which parasites exhibit antigenic variation
Opsonization - neutralization and complement activation
SLE - nonspecific
Trypanosomes - programmed rearrangement
Paracortex

14. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
Neisseria bacteremia
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Leukocyte adhesion deficiency type 1

15. Which infections require administering passive immunity?
Hyper IgM
Hereditary angioedema
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Paracortex

16. anti basement membrane
Goodpastures
DiGeorge
III
CD21

17. What is the difference in antigenic variation in viruses
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Major shift minor drift
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Fc

18. X- linked recessive defect with progessive deletion of B and T cells
Signal 1 = APC - signal 2 = B7 and CD28
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Goodpastures
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

19. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Mixed connective tissue disease
I
IgG
IgA

20. which follicles (primary or secondary) have active germinal centers?
Secondary
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Macs - dendritic cell - B cell
III

21. antismooth muscle
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Opsonization - neutralization and complement activation
Autoimmune hepatitis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

22. Transplant rejection: preformed host antibody mediated
Primary biliary cirrohosis
Hyperacute : occlusion - ischemia - necrosis
Perforin - granzyme - granulysin
Howell - Jolly bodies - Target cells - thrombocytosis

23. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
III
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Right arm and right half of head
Corticomedullary junction

24. How do CD8 cells kill?
Signal 1 = APC - signal 2 = B7 and CD28
C3b
Fc and Fab
Perforin - granzyme - granulysin

25. transplant rejection: T cell and antibody mediated vasular damage
CD8 cells
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Chronic: fibrosis of graft tissue and blood vessels
III

26. What are the 4 T's of type IV hypersense
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Signal 1 = APC - signal 2 = B7 and CD28
C3b
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

27. What cytokines to Th2 cells secrete?
Common variable immunodeficiency (CVID)
Wegeners granulomatosis
IL-4 - 5 - 10
IgG - IgM GM makes classic cars

28. What does a deficiency in C5- C8 lead to?
Everything else - not right arm and right half of head
Hemochromocytosis
IL-12 def
Neisseria bacteremia

29. Antimitochondrial
Primary biliary cirrohosis
Chediak Higashi
IgM and IgD
Trypanosomes - programmed rearrangement

30. What is the arthus rxn?
Sjorgen's syndrome
Regulates the humoral response
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

31. What kind of hypersens rxn in anaphylaxis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
SLE
I
DM type 1

32. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Scleroderma CREST
Upper limb and breast

33. Which antibody mediates a type Hypersens rxn?
No - peptides only can can be presented on MHC molecules
SLE - nonspecific
IgE
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

34. What kind of bacteria do macrophages remove from the spleen?
CD40 and CD40L
CD14
APCs - and DR - DP and DQ
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

35. Which bacteria secrete superantigen
S. aureus and S. pyogenes
Other vasculitidies
Drug induced lupus
IgG

36. Which cytokine inhibits Th1 cells
IL-10
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

37. ANA
Superficial inguinal pectinate line
Scleroderma CREST
Pemphigus vulgaris
SLE - nonspecific

38. c - ANCA
Common variable immunodeficiency (CVID)
Stomach
Wegeners granulomatosis
CD56

39. Deficiency in DAF
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Wegeners granulomatosis
Hashimotos
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

40. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Fc and Fab
CD56
SCID
Hyper IgM

41. p - ANCA
Prevents attachment of bacteria and viruses to mucous membranes
Opsonization - neutralization and complement activation
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Other vasculitidies

42. Cell surface receptors on T cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Upper limb and breast
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Poly/dermato myositis

43. Which MHC complex to CD8 cells bind
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Scleroderma CREST
MHC I
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

44. Where is MHC II expressed and and which HLA molecules codes for it
IL-10
Chronic mucocutaneaous candidiasis
PMNs recruited by IL-8 to clear infxns
APCs - and DR - DP and DQ

45. What are the three APCs
PMNs recruited by IL-8 to clear infxns
Hyper IgM
Macs - dendritic cell - B cell
Chronic granulomatous disease

46. What is the clinical picture for serum sickness?
Macs - dendritic cell - B cell
IgM and IgD
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Mature t cells - epithelial reticular cells - Hassalls corpuscles

47. Which kind of immunity is germline encoded?
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
C3b
Innate
I

48. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
Signal 1 = APC - signal 2 = B7 and CD28
Pemphigus vulgaris
Graves' dz

49. Which receptor on MACS to endotoxin directy stimulate?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Ataxia telangectasia
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD14

50. HLA- DR5
DM type 1
Howell - Jolly bodies - Target cells - thrombocytosis
IgG
Pernicious anemia (to B12 def) - hashimotos thyroiditis