Immunology

Instructions:

• Answer 50 questions in 15 minutes.
• If you are not ready to take this test, you can study here.
• Match each statement with the correct term.
• Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Th cells don't produce IFN gamma - no PMN response

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2. Which cell mediates the type IV hypersens rxn?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Graves' dz
CD8 cells
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein


3. HLA- B8

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4. How do CD8 cells kill?
All nucleated cells (no RBCs) A - B - C
IgA
Perforin - granzyme - granulysin
IL-2 and IFN gamma


5. Cell surface receptors on T cells
Wegeners granulomatosis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Common variable immunodeficiency (CVID)
Steroid - responsive nephrotic syndrome


6. What cytokines to Th2 cells secrete?
2
IL-4 - 5 - 10
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Graves' dz


7. What happens in the follicle of the lymph node
B cell localization and proliferation
Paracortex
Common variable immunodeficiency (CVID)
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant


8. Which MHC complex to CD8 cells bind
IgE
SCID
Hereditary angioedema
MHC I


9. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Selective Ig def - IgA most common
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgM and IgD


10. p - ANCA
Graves' dz
Scleroderma diffuse
Other vasculitidies
IgM


11. Anti - IgG (RF)
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-12
Chronic: fibrosis of graft tissue and blood vessels
RA


12. Which antibodies activate the classic pathway
CD40 and CD40L
Fab
IgA
IgG - IgM GM makes classic cars


13. Transplant rejection: preformed host antibody mediated
No - peptides only can can be presented on MHC molecules
IgA
Hyperacute : occlusion - ischemia - necrosis
Opsonization - neutralization and complement activation


14. antismooth muscle
Autoimmune hepatitis
CD40 and CD40L
Prevents attachment of bacteria and viruses to mucous membranes
Steroid - responsive nephrotic syndrome


15. anti U1 RNP
Fab
C5b -9
Mixed connective tissue disease
Stomach


16. How are NK cells stimulated?
All nucleated cells (no RBCs) A - B - C
Neisseria bacteremia
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-12 - IFN- beta. IFN- alpha


17. decreased Th1 response
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Poly/dermato myositis
IL-12 def
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure


18. anti glutamate decarboxylase
IgG
Upper limb and breast
DM type 1
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II


19. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Fc
DiGeorge
Innate
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant


20. anti SS A/B or anti Ro/La

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21. Which areas of the body are drained by the axillary lymph node
Scleroderma CREST
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Upper limb and breast
Graves' dz


22. Defectin in isotype switching
Superficial inguinal pectinate line
Ataxia telangectasia
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Selective Ig def - IgA most common


23. What are the cell surface receptors on MACS
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IL-10


24. Which complement proteins make up the MAC
Hyperacute : occlusion - ischemia - necrosis
Mesenchyme
C5b -9
DiGeorge


25. Which B T cell interaction allows for immunologic memory and class switching?
IgG
IL-12 def
CD40 and CD40L
II


26. What does the thoracic duct drain?
Everything else - not right arm and right half of head
Chronic granulomatous disease
Corticomedullary junction
CD40 and CD40L


27. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
Chronic granulomatous disease
IgA
Perforin - granzyme - granulysin


28. Antimitochondrial
IL-12 - IFN- beta. IFN- alpha
IFN gamma
Primary biliary cirrohosis
PMNs recruited by IL-8 to clear infxns


29. What kind of hypersens rxn in anaphylaxis
Hemochromocytosis
Chronic mucocutaneaous candidiasis
Chronic granulomatous disease
I


30. What does a deficiency in C1 esterase inhibitor lead to?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Chronic mucocutaneaous candidiasis
DM type 1
Hereditary angioedema


31. Which bacteria secrete superantigen
Major shift minor drift
C3b
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
S. aureus and S. pyogenes


32. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
Hyper IgE syndrome (Job's)
Chronic: fibrosis of graft tissue and blood vessels
C3b


33. Which antibody (IgM or IgG) crosses the placenta?
C5b -9
Common variable immunodeficiency (CVID)
Adaptive
IgG


34. antigliadin - antiendomysial
CD8 cells
Ceilac disase
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
MHC I


35. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Perforin - granzyme - granulysin
C5b -9
Hashimotos
No - peptides only can can be presented on MHC molecules


36. HLA- B27

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37. Which kind of immunity is germline encoded?
Il -4
Chediak Higashi
MHC II 4 x 2=8
Innate


38. c - ANCA
Chronic mucocutaneaous candidiasis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
PMNs recruited by IL-8 to clear infxns
Wegeners granulomatosis


39. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
IL-4 - 5 - 10
S. aureus and S. pyogenes
CD8 cells


40. HLA- D2

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41. Antihistone
III
III
DM type 1
Drug induced lupus


42. Deficiency in DAF
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgM
III
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2


43. Defect in CD40L on helper T
Hyper IgM
Fc and Fab
Major shift minor drift
IgM


44. Which cytokine induces Th2 cell profile in CD4 cells
C3b
Ceilac disase
Il -4
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate


45. What is the unique cell marker for NK cells
Paracortex
CD56
Major shift minor drift
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho


46. Which immunoglobulin is a pentamer
IgM
Adaptive
2
IV


47. What are the 4 T's of type IV hypersense
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
MS - hay fever - SLE - goodpasture's
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Hyperacute : occlusion - ischemia - necrosis


48. transplant rejection: T cell and antibody mediated vasular damage
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Chronic: fibrosis of graft tissue and blood vessels
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Mesenchyme


49. Which receptor on MACS to endotoxin directy stimulate?
Howell - Jolly bodies - Target cells - thrombocytosis
CD14
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
II


50. What are the two signals in cytotoxic T cells activation?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Prevents attachment of bacteria and viruses to mucous membranes
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II