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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Trypanosomes - programmed rearrangement
CD14
IgG
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

2. What is the main function of IgA
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Hemochromocytosis
Prevents attachment of bacteria and viruses to mucous membranes
C5b -9

3. anti - Jo 1
Poly/dermato myositis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Other vasculitidies
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

4. Defect in LFA-1 integrin CD18 protein on phagocytes
CD56
Mesenchyme
IL-2 and IFN gamma
Leukocyte adhesion deficiency type 1

5. HLA- D2

6. Which antibody mediates a type Hypersens rxn?
IgG
SCID
IgE
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

7. What cytokines to Th2 cells secrete?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IL-4 - 5 - 10
All nucleated cells (no RBCs) A - B - C
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

8. What does the Th2 response do?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Regulates the humoral response
Hyper IgM
Chronic granulomatous disease

9. What are the three things you find post splenectomy
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Everything else - not right arm and right half of head
Howell - Jolly bodies - Target cells - thrombocytosis
Autoimmune hepatitis

10. Which cytokine inhibits Th1 cells
Superficial inguinal pectinate line
MHC II 4 x 2=8
MHC I
IL-10

11. Which is the most abundant immunoglobulin in the blood?
Opsonization - neutralization and complement activation
MHC I
IgG
Trypanosomes - programmed rearrangement

12. Which parasites exhibit antigenic variation
IgE
Trypanosomes - programmed rearrangement
PMNs recruited by IL-8 to clear infxns
Bruton's agamma

13. What is the difference in antigenic variation in viruses
Scleroderma CREST
Major shift minor drift
Everything else - not right arm and right half of head
IV

14. HLA- B27

15. How many signals are required for T cell activation or B cell class switching?
Corticomedullary junction
IL-12 def
Leukocyte adhesion deficiency type 1
2

16. antigliadin - antiendomysial
Ceilac disase
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Scleroderma CREST
MHC I

17. What inhibits Th2 cells
IFN gamma
MHC I
Opsonization - neutralization and complement activation
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

18. Antihistone
MHC I
Drug induced lupus
Prevents attachment of bacteria and viruses to mucous membranes
IgM and IgD

19. ANA
SLE - nonspecific
Superficial inguinal pectinate line
Major shift minor drift
Graves' dz

20. Which infections require administering passive immunity?
Pemphigus vulgaris
IgE
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

21. What embryologic tissue are lymphcytes derived from
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IgM
IFN gamma
Mesenchyme

22. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Il -4
Regulates the humoral response
Chronic granulomatous disease
MHC I

23. Which type of hypersens rxn is the arthus rxn
Corticomedullary junction
Macs - dendritic cell - B cell
III
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

24. p - ANCA
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Drug induced lupus
Other vasculitidies
MHC II 4 x 2=8

25. What is the role of CD4 cels
No - peptides only can can be presented on MHC molecules
Signal 1 = APC - signal 2 = B7 and CD28
Help B cells make antibody - secrete IFN gamma to activate macs
CD40 and CD40L

26. Which immunoglobulin is a pentamer
RA
IgM
Drug induced lupus
Opsonization - neutralization and complement activation

27. anti U1 RNP
IgG
Fc
Mixed connective tissue disease
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

28. Which complement protein opsonizes bacteria?
Scleroderma CREST
IL-2 and IFN gamma
IgG
C3b

29. HLA- DR4
Upper limb and breast
Poly/dermato myositis
RA - DM type 1
SLE

30. Cell surface receptors on B cels
Hyper IgM
DM type 1
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

31. Which type of hypersens rxn is antibody mediated?
Scleroderma diffuse
II
DM type 1
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

32. Anti Scl 70 (DNA topo I
Scleroderma diffuse
DM type 1
Regulates the humoral response
Primary biliary cirrohosis

33. Which is the receptors for EBV?
Leukocyte adhesion deficiency type 1
IL-2 and IFN gamma
CD21
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

34. HLA- B8

35. What are the three APCs
Macs - dendritic cell - B cell
Help B cells make antibody - secrete IFN gamma to activate macs
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Perforin - granzyme - granulysin

36. Where is MHC II expressed and and which HLA molecules codes for it
Goodpastures
Opsonization - neutralization and complement activation
APCs - and DR - DP and DQ
All nucleated cells (no RBCs) A - B - C

37. What is the arthus rxn?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
2
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

38. Which type of hypersens rxn is serum sickness?
2
RA - DM type 1
III
MHC II 4 x 2=8

39. Which portion of the antibody determines the isotype
Hyper IgE syndrome (Job's)
IgG
Neisseria bacteremia
Fc

40. Which areas of the body are drained by the axillary lymph node
Other vasculitidies
Ceilac disase
DiGeorge
Upper limb and breast

41. T cell dysfunction
Chronic mucocutaneaous candidiasis
RA
MHC II 4 x 2=8
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

42. Where is MHC I expressed - and which HLA molecules code for it
III
Paracortex
All nucleated cells (no RBCs) A - B - C
IgG

43. How do NK cells kill?
IFN gamma
B cell localization and proliferation
Steroid - responsive nephrotic syndrome
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

44. What kind of bacteria do macrophages remove from the spleen?
SCID
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Hashimotos
Neisseria bacteremia

45. What are the cytokines involved in macrophage/lymphocyte interaction
Chronic: fibrosis of graft tissue and blood vessels
Help B cells make antibody - secrete IFN gamma to activate macs
Selective Ig def - IgA most common
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

46. HLA- A3
Superficial inguinal pectinate line
Howell - Jolly bodies - Target cells - thrombocytosis
Hemochromocytosis
Chronic: fibrosis of graft tissue and blood vessels

47. X linked recessive defect in BTK no B cell differentiation

48. Which bacteria secrete superantigen
APCs - and DR - DP and DQ
S. aureus and S. pyogenes
IgM
RA - DM type 1

49. decreased Th1 response
IL-12 def
Graves' dz
Other vasculitidies
Primary biliary cirrohosis

50. Anticentromere
Scleroderma CREST
Help B cells make antibody - secrete IFN gamma to activate macs
Upper limb and breast
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate