Immunology

Instructions:

• Answer 50 questions in 15 minutes.
• If you are not ready to take this test, you can study here.
• Match each statement with the correct term.
• Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. AR - defect in microtubule fxn with decreased phagocytosis
DiGeorge
Chediak Higashi
IgM
Scleroderma diffuse


2. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Sjorgen's syndrome
Ataxia telangectasia
Opsonization - neutralization and complement activation


3. What inhibits Th2 cells
IgG - IgM GM makes classic cars
APCs - and DR - DP and DQ
I
IFN gamma


4. HLA- D2

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5. which areas of the body are drained by the celiac lymph node?
IL-4 - 5 - 10
Stomach
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Regulates the humoral response


6. Defect in CD40L on helper T
S. aureus and S. pyogenes
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Fc
Hyper IgM


7. What does a deficiency in C5- C8 lead to?
IgG - IgM GM makes classic cars
III
Neisseria bacteremia
Mesenchyme


8. Th cells don't produce IFN gamma - no PMN response

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9. What is the role of CD4 cels
Innate
Help B cells make antibody - secrete IFN gamma to activate macs
Chediak Higashi
DiGeorge


10. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
IgM and IgD
Fc
Adaptive
Chronic granulomatous disease


11. Which cytokine induces Th2 cell profile in CD4 cells
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Il -4
Corticomedullary junction
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b


12. antidesmoglein
RA - DM type 1
Pemphigus vulgaris
Autoimmune hepatitis
Drug induced lupus


13. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgA
No - peptides only can can be presented on MHC molecules
Upper limb and breast


14. HLA- B27

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15. What are the two signals in cytotoxic T cells activation?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Corticomedullary junction


16. Which immunoglobulin is a pentamer
IgM
Bruton's agamma
CD21
IL-12


17. What are the classic example of bacterial antigen variation and the unique mechanims
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
RA - DM type 1
Superficial inguinal pectinate line


18. Antihistone
Drug induced lupus
IL-12
III
RA - DM type 1


19. What is the difference in antigenic variation in viruses
Hemochromocytosis
SCID
Major shift minor drift
Hashimotos


20. Which B T cell interaction allows for immunologic memory and class switching?
MHC I
CD40 and CD40L
Secondary
I


21. X linked recessive defect in BTK no B cell differentiation

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22. Which antibody (IgM or IgG) crosses the placenta?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
MHC II 4 x 2=8
IgG
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin


23. antigliadin - antiendomysial
Ceilac disase
Selective Ig def - IgA most common
SLE - nonspecific
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly


24. Anti - IgG (RF)
RA
Superficial inguinal pectinate line
II
DM type 1


25. Cell surface receptors on B cels
IgA
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Goodpastures


26. T cell dysfunction
Chronic mucocutaneaous candidiasis
DM type 1
Major shift minor drift
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure


27. Which lymph node drains the anal canal below
Superficial inguinal pectinate line
IgG
Il -4
II


28. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Major shift minor drift
2


29. What is the main function of IgA
Macs - dendritic cell - B cell
Prevents attachment of bacteria and viruses to mucous membranes
IgM and IgD
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome


30. Which receptor on MACS to endotoxin directy stimulate?
CD14
MHC II 4 x 2=8
Innate
Ataxia telangectasia


31. Which MHC complex to CD8 cells bind
Hyper IgM
MHC I
SLE - nonspecific
Stomach


32. Which MHC complex to CD4 cells bind
Common variable immunodeficiency (CVID)
IL-12 def
Chediak Higashi
MHC II 4 x 2=8


33. which follicles (primary or secondary) have active germinal centers?
Secondary
Poly/dermato myositis
DiGeorge
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria


34. Which type of hypersens rxn is delayed
IL-12 def
IV
Sjorgen's syndrome
Pernicious anemia (to B12 def) - hashimotos thyroiditis


35. Defect in DNA repair enzymes
Mesenchyme
IgG
Ataxia telangectasia
Howell - Jolly bodies - Target cells - thrombocytosis


36. Which type of hypersens rxn is the arthus rxn
Hyper IgE syndrome (Job's)
III
MHC I
Common variable immunodeficiency (CVID)


37. What are the three things you find post splenectomy
Hashimotos
Howell - Jolly bodies - Target cells - thrombocytosis
IgM and IgD
Goodpastures


38. Which area of the lymph node englarges in an extreme immune response
Hashimotos
Paracortex
Graves' dz
Neisseria bacteremia


39. Which cytokines to Th1 cells secrete?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-2 and IFN gamma
APCs - and DR - DP and DQ
C3b


40. How do CD8 cells kill?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Perforin - granzyme - granulysin
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IL-12 def


41. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Prevents attachment of bacteria and viruses to mucous membranes
Adaptive
Wegeners granulomatosis


42. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
SCID
Major shift minor drift
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant


43. p - ANCA
Chronic: fibrosis of graft tissue and blood vessels
Everything else - not right arm and right half of head
Hereditary angioedema
Other vasculitidies


44. What does a deficiency in C3 lead to...
Paracortex
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
I
Secondary


45. What are the cell surface receptors on MACS
Bruton's agamma
I
IgG
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b


46. What is the unique cell marker for NK cells
SCID
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
CD56
Chediak Higashi


47. What is the clinical picture for serum sickness?
Paracortex
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
MHC II 4 x 2=8


48. HLA- B8

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49. which kind of immunity is characterized by receptors that undergo VDJ recombination?
MS - hay fever - SLE - goodpasture's
Ceilac disase
Adaptive
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria


50. What embryologic tissue are lymphcytes derived from
Help B cells make antibody - secrete IFN gamma to activate macs
Mesenchyme
Macs - dendritic cell - B cell
Chediak Higashi