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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. which follicles (primary or secondary) have active germinal centers?
Secondary
Hyper IgM
Right arm and right half of head
Drug induced lupus

2. Which lymph node drains the anal canal below
Fc
Scleroderma CREST
Paracortex
Superficial inguinal pectinate line

3. What are the 3 funxtions of antibodies?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
DM type 1
Opsonization - neutralization and complement activation
II

4. What are the 4 T's of type IV hypersense
Il -4
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IV
Primary biliary cirrohosis

5. Cell surface receptors on T cells
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Sjorgen's syndrome
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-4 - 5 - 10

6. What does the Th2 response do?
Regulates the humoral response
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Hyper IgM
Upper limb and breast

7. What are the cell surface receptors on MACS
Selective Ig def - IgA most common
Wegeners granulomatosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
CD56

8. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
SLE
Upper limb and breast
C5b -9

9. Which MHC complex to CD4 cells bind
Secondary
C3b
Steroid - responsive nephrotic syndrome
MHC II 4 x 2=8

10. Where do positive and negative selection occur in the thymus?
Ataxia telangectasia
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Corticomedullary junction
PMNs recruited by IL-8 to clear infxns

11. How do NK cells kill?
I
IgG - IgM GM makes classic cars
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
CD40 and CD40L

12. What does a deficiency in C1 esterase inhibitor lead to?
Prevents attachment of bacteria and viruses to mucous membranes
Superficial inguinal pectinate line
All nucleated cells (no RBCs) A - B - C
Hereditary angioedema

13. HLA- DR3
Chronic granulomatous disease
Major shift minor drift
DM type 1
MHC II 4 x 2=8

14. Which infections require administering passive immunity?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Perforin - granzyme - granulysin
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

15. Defectin in isotype switching
Selective Ig def - IgA most common
Scleroderma diffuse
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IV

16. Which type of hypersens rxn is delayed
IgM and IgD
IV
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
DM type 1

17. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
III
No - peptides only can can be presented on MHC molecules
Superficial inguinal pectinate line
MHC I

18. HLA- B8

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19. What are the two signals required for B cells class switching?
Ataxia telangectasia
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
CD40 and CD40L
PMNs recruited by IL-8 to clear infxns

20. Antimitochondrial
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Superficial inguinal pectinate line
Primary biliary cirrohosis
Goodpastures

21. What is the arthus rxn?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
CD21
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Graves' dz

22. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
SCID
Hashimotos
IgG

23. What is the main function of IgA
Primary biliary cirrohosis
Il -4
Prevents attachment of bacteria and viruses to mucous membranes
Goodpastures

24. antimicrosomal - antithyroglobulin
Hashimotos
Help B cells make antibody - secrete IFN gamma to activate macs
IL-4 - 5 - 10
CD40 and CD40L

25. Which is the most abundant immunoglobulin in the blood?
IgG
Leukocyte adhesion deficiency type 1
Fab
Steroid - responsive nephrotic syndrome

26. Which parts of the antibody to light chain contribute
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Fab
Graves' dz
DiGeorge

27. Which parts of the antibody to heavy chain contribute?
RA - DM type 1
Fc and Fab
CD56
IL-12 def

28. What is the clinical picture for serum sickness?
Signal 1 = APC - signal 2 = B7 and CD28
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

29. What interferes with viruses?
Upper limb and breast
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Bruton's agamma

30. Which cell mediates the type IV hypersens rxn?
CD8 cells
Pemphigus vulgaris
Bruton's agamma
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

31. which areas of the body are drained by the celiac lymph node?
IL-12 def
III
Stomach
Prevents attachment of bacteria and viruses to mucous membranes

32. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
Upper limb and breast
SLE - nonspecific
Howell - Jolly bodies - Target cells - thrombocytosis

33. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
Signal 1 = APC - signal 2 = B7 and CD28
Drug induced lupus
Right arm and right half of head

34. transplant rejection: T cell and antibody mediated vasular damage
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Other vasculitidies
Chronic: fibrosis of graft tissue and blood vessels
B cell localization and proliferation

35. Defect in LFA-1 integrin CD18 protein on phagocytes
SLE
PMNs recruited by IL-8 to clear infxns
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Leukocyte adhesion deficiency type 1

36. Which cytokines to Th1 cells secrete?
Ceilac disase
IL-2 and IFN gamma
RA
IgE

37. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
Goodpastures
Prevents attachment of bacteria and viruses to mucous membranes
Help B cells make antibody - secrete IFN gamma to activate macs

38. HLA- B27

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39. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Hereditary angioedema
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Wegeners granulomatosis

40. Which is the receptors for EBV?
Other vasculitidies
Autoimmune hepatitis
CD21
Fc and Fab

41. What cytokines to Th2 cells secrete?
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
CD21
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-4 - 5 - 10

42. What is the unique cell marker for NK cells
Scleroderma CREST
Bruton's agamma
CD56
RA

43. Which antibody mediates a type Hypersens rxn?
Upper limb and breast
IFN gamma
IgE
SLE - nonspecific

44. Which portion of the antibody determines the isotype
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-12 - IFN- beta. IFN- alpha
Fc
Fc and Fab

45. Deficiency in DAF
Adaptive
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
All nucleated cells (no RBCs) A - B - C
IFN gamma

46. What inhibits Th2 cells
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
B cell localization and proliferation
Wegeners granulomatosis
IFN gamma

47. thwat does the Right lymphatic duct drain?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Right arm and right half of head
C3b
Pemphigus vulgaris

48. Which bacteria secrete superantigen
CD56
Hyper IgM
S. aureus and S. pyogenes
Adaptive

49. HLA- DR4
S. aureus and S. pyogenes
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Secondary
RA - DM type 1

50. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
MHC II 4 x 2=8
SLE - nonspecific
Superficial inguinal pectinate line