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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. How do CD8 cells kill?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Trypanosomes - programmed rearrangement
Perforin - granzyme - granulysin
Hyper IgM

2. T cell dysfunction
Chronic mucocutaneaous candidiasis
APCs - and DR - DP and DQ
Goodpastures
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

3. which areas of the body are drained by the celiac lymph node?
Stomach
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
C5b -9
II

4. What does a deficiency in C3 lead to...
Scleroderma CREST
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

5. What do superantigens do?
Secondary
RA - DM type 1
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Sjorgen's syndrome

6. Which infections require administering passive immunity?
Opsonization - neutralization and complement activation
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
DM type 1

7. Where do positive and negative selection occur in the thymus?
Mesenchyme
MHC II 4 x 2=8
III
Corticomedullary junction

8. What kind of hypersens rxn in anaphylaxis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-10
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
I

9. transplant rejection: T cell and antibody mediated vasular damage
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Chronic: fibrosis of graft tissue and blood vessels
Graves' dz
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

10. What do mature B lymphos express on their surface?
Major shift minor drift
IgM and IgD
Fc and Fab
Ceilac disase

11. Which parasites exhibit antigenic variation
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
I
Trypanosomes - programmed rearrangement
Other vasculitidies

12. What happens in the follicle of the lymph node
B cell localization and proliferation
Hereditary angioedema
Prevents attachment of bacteria and viruses to mucous membranes
MHC II 4 x 2=8

13. What do you find in the medulla of the thymus?
Scleroderma CREST
Common variable immunodeficiency (CVID)
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgA

14. HLA- B8

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15. anti SS A/B or anti Ro/La

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16. Which type of hypersens rxn is antibody mediated?
Common variable immunodeficiency (CVID)
Scleroderma diffuse
Bruton's agamma
II

17. What does the thoracic duct drain?
Il -4
IV
Everything else - not right arm and right half of head
Fc

18. Transplant rejection: preformed host antibody mediated
APCs - and DR - DP and DQ
Hyperacute : occlusion - ischemia - necrosis
Signal 1 = APC - signal 2 = B7 and CD28
Common variable immunodeficiency (CVID)

19. Which areas of the body are drained by the axillary lymph node
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Upper limb and breast
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Steroid - responsive nephrotic syndrome

20. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
RA - DM type 1
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Chronic granulomatous disease

21. Which is the receptors for EBV?
Fc
Right arm and right half of head
CD21
APCs - and DR - DP and DQ

22. What is the clinical picture for serum sickness?
IL-2 and IFN gamma
I
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Other vasculitidies

23. HLA- DR5
Primary biliary cirrohosis
Poly/dermato myositis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
No - peptides only can can be presented on MHC molecules

24. Which type of hypersens rxn is delayed
No - peptides only can can be presented on MHC molecules
IV
Mixed connective tissue disease
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

25. HLA- B27

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26. Where is MHC II expressed and and which HLA molecules codes for it
Graves' dz
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
APCs - and DR - DP and DQ

27. What kind of bacteria do macrophages remove from the spleen?
Drug induced lupus
No - peptides only can can be presented on MHC molecules
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgG

28. Antimitochondrial
Chronic mucocutaneaous candidiasis
Trypanosomes - programmed rearrangement
Paracortex
Primary biliary cirrohosis

29. thwat does the Right lymphatic duct drain?
Hereditary angioedema
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Right arm and right half of head
IL-12

30. What are the classic example of bacterial antigen variation and the unique mechanims
SCID
Adaptive
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

31. Th cells don't produce IFN gamma - no PMN response

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32. Which portion of the antibody determines the isotype
Il -4
Major shift minor drift
Fc
Corticomedullary junction

33. What are the 3 funxtions of antibodies?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
III
Opsonization - neutralization and complement activation
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

34. Which cell mediates the type IV hypersens rxn?
Neisseria bacteremia
CD8 cells
Scleroderma diffuse
DM type 1

35. Defectin in isotype switching
DM type 1
C3b
IgA
Selective Ig def - IgA most common

36. Which complement protein opsonizes bacteria?
Chronic mucocutaneaous candidiasis
I
C3b
RA

37. What is the unique cell marker for NK cells
CD14
CD56
IL-12 def
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

38. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Corticomedullary junction
III
Selective Ig def - IgA most common

39. Cell surface receptors on B cels
Scleroderma diffuse
IL-12
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Fab

40. What are the two signals in helper T activation?
Secondary
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Signal 1 = APC - signal 2 = B7 and CD28
Hyper IgM

41. How do NK cells kill?
C3b
Wegeners granulomatosis
RA
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

42. Antihistone
III
Drug induced lupus
IFN gamma
Help B cells make antibody - secrete IFN gamma to activate macs

43. Which parts of the antibody to light chain contribute
CD56
Fab
MHC I
Macs - dendritic cell - B cell

44. Where is MHC I expressed - and which HLA molecules code for it
Goodpastures
Hashimotos
Other vasculitidies
All nucleated cells (no RBCs) A - B - C

45. Which immunoglobulin is a pentamer
I
IgM
CD14
Upper limb and breast

46. anti U1 RNP
Howell - Jolly bodies - Target cells - thrombocytosis
Il -4
DiGeorge
Mixed connective tissue disease

47. What are the three APCs
Stomach
DM type 1
III
Macs - dendritic cell - B cell

48. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
IgG
IgG
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

49. Which cytokine induces Th2 cell profile in CD4 cells
Mixed connective tissue disease
Il -4
IgG - IgM GM makes classic cars
Hyper IgM

50. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgG
Innate
SCID