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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. HLA- A3
Il -4
Common variable immunodeficiency (CVID)
Trypanosomes - programmed rearrangement
Hemochromocytosis

2. Defect in B cell maturation
Common variable immunodeficiency (CVID)
Hyperacute : occlusion - ischemia - necrosis
Scleroderma diffuse
Other vasculitidies

3. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Mesenchyme
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

4. anti basement membrane
Wegeners granulomatosis
IgG
Goodpastures
IgE

5. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Corticomedullary junction
Adaptive
CD21
IgE

6. Anticentromere
IL-2 and IFN gamma
Adaptive
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Scleroderma CREST

7. thwat does the Right lymphatic duct drain?
Mesenchyme
Right arm and right half of head
DM type 1
All nucleated cells (no RBCs) A - B - C

8. antigliadin - antiendomysial
CD40 and CD40L
Ceilac disase
No - peptides only can can be presented on MHC molecules
Corticomedullary junction

9. Which antibodies activate the classic pathway
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-10
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgG - IgM GM makes classic cars

10. What do you find in the medulla of the thymus?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
S. aureus and S. pyogenes
Mature t cells - epithelial reticular cells - Hassalls corpuscles
MHC II 4 x 2=8

11. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

12. Transplant rejection: preformed host antibody mediated
IL-12
RA - DM type 1
Fc and Fab
Hyperacute : occlusion - ischemia - necrosis

13. What do mature B lymphos express on their surface?
Regulates the humoral response
IL-12 - IFN- beta. IFN- alpha
IgM and IgD
IgG

14. Antimitochondrial
Right arm and right half of head
Ceilac disase
Primary biliary cirrohosis
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

15. Where do positive and negative selection occur in the thymus?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Neisseria bacteremia
RA - DM type 1
Corticomedullary junction

16. Antihistone
C3b
Hyperacute : occlusion - ischemia - necrosis
Drug induced lupus
IL-12 def

17. Which receptor on MACS to endotoxin directy stimulate?
Mixed connective tissue disease
Pernicious anemia (to B12 def) - hashimotos thyroiditis
CD14
Primary biliary cirrohosis

18. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Macs - dendritic cell - B cell
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
SCID
Hemochromocytosis

19. p - ANCA
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Other vasculitidies
Pemphigus vulgaris
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

20. Which type of hypersens rxn is antibody mediated?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
II
IV
DM type 1

21. Defectin in isotype switching
Fab
Hashimotos
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Selective Ig def - IgA most common

22. HLA- B27

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23. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
SLE
All nucleated cells (no RBCs) A - B - C
IL-2 and IFN gamma

24. Which parts of the antibody to heavy chain contribute?
Right arm and right half of head
Fc and Fab
Goodpastures
C3b

25. How many signals are required for T cell activation or B cell class switching?
2
DM type 1
Adaptive
Macs - dendritic cell - B cell

26. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Corticomedullary junction
SLE - nonspecific
DM type 1

27. anti - Jo 1
Poly/dermato myositis
Hereditary angioedema
Corticomedullary junction
Il -4

28. Which area of the lymph node englarges in an extreme immune response
Paracortex
III
IFN gamma
Signal 1 = APC - signal 2 = B7 and CD28

29. X linked recessive defect in BTK no B cell differentiation

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30. What are the two signals in helper T activation?
Drug induced lupus
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Signal 1 = APC - signal 2 = B7 and CD28
IgG

31. What is the role of CD4 cels
Neisseria bacteremia
Bruton's agamma
Help B cells make antibody - secrete IFN gamma to activate macs
RA - DM type 1

32. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
SCID
Selective Ig def - IgA most common
Stomach

33. ANA
Ataxia telangectasia
SLE - nonspecific
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Other vasculitidies

34. antismooth muscle
Neisseria bacteremia
Stomach
Autoimmune hepatitis
Regulates the humoral response

35. What does HOT- T- Bone stEAk stand for?
Innate
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Macs - dendritic cell - B cell
Goodpastures

36. What is the main function of IgA
IL-2 and IFN gamma
Fab
Prevents attachment of bacteria and viruses to mucous membranes
DiGeorge

37. How are NK cells stimulated?
DM type 1
Fc
Drug induced lupus
IL-12 - IFN- beta. IFN- alpha

38. Which type of hypersens rxn is the arthus rxn
IgG
IgM
Pemphigus vulgaris
III

39. anti U1 RNP
Mixed connective tissue disease
RA - DM type 1
Graves' dz
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

40. What cytokines to Th2 cells secrete?
IL-4 - 5 - 10
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Chronic mucocutaneaous candidiasis
Paracortex

41. Which cytokine induces Th1 cell profile in CD4 cells
Leukocyte adhesion deficiency type 1
IL-12
RA
Ataxia telangectasia

42. Which kind of immunity is germline encoded?
Innate
Prevents attachment of bacteria and viruses to mucous membranes
IL-12 def
RA

43. Anti - IgG (RF)
RA
Primary biliary cirrohosis
Autoimmune hepatitis
Scleroderma diffuse

44. anti glutamate decarboxylase
SCID
Il -4
DM type 1
Hereditary angioedema

45. Which immunoglobulin is a pentamer
Corticomedullary junction
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
SLE
IgM

46. which areas of the body are drained by the celiac lymph node?
IgG - IgM GM makes classic cars
Stomach
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IL-10

47. What does the thoracic duct drain?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
RA - DM type 1
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Everything else - not right arm and right half of head

48. What is the difference in antigenic variation in viruses
No - peptides only can can be presented on MHC molecules
Major shift minor drift
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Hereditary angioedema

49. Where is MHC II expressed and and which HLA molecules codes for it
Signal 1 = APC - signal 2 = B7 and CD28
APCs - and DR - DP and DQ
DM type 1
IFN gamma

50. What are the classic example of bacterial antigen variation and the unique mechanims
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgM and IgD
Paracortex