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Test your basic knowledge |
Immunology
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Study First
Subject
:
health-sciences
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Defect in B cell maturation
Common variable immunodeficiency (CVID)
IL-4 - 5 - 10
Hereditary angioedema
Scleroderma diffuse
2. What are the two signals in cytotoxic T cells activation?
Chronic: fibrosis of graft tissue and blood vessels
Hereditary angioedema
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Trypanosomes - programmed rearrangement
3. Which is the receptors for EBV?
CD21
Hyperacute : occlusion - ischemia - necrosis
IL-12 def
IL-12 - IFN- beta. IFN- alpha
4. Where is MHC II expressed and and which HLA molecules codes for it
SCID
IFN gamma
APCs - and DR - DP and DQ
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
5. Which cytokines to Th1 cells secrete?
III
IL-2 and IFN gamma
I
APCs - and DR - DP and DQ
6. How many signals are required for T cell activation or B cell class switching?
PMNs recruited by IL-8 to clear infxns
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Major shift minor drift
2
7. Defect in LFA-1 integrin CD18 protein on phagocytes
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Leukocyte adhesion deficiency type 1
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Wegeners granulomatosis
8. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
Right arm and right half of head
Howell - Jolly bodies - Target cells - thrombocytosis
Signal 1 = APC - signal 2 = B7 and CD28
9. What does a deficiency in C3 lead to...
Selective Ig def - IgA most common
C5b -9
Paracortex
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
10. What inhibits Th2 cells
2
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG
IFN gamma
11. What are the cell surface receptors on MACS
IgG - IgM GM makes classic cars
RA - DM type 1
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Bruton's agamma
12. HLA- D2
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13. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
Goodpastures
Prevents attachment of bacteria and viruses to mucous membranes
Right arm and right half of head
14. What are the 3 funxtions of antibodies?
SCID
Opsonization - neutralization and complement activation
Ceilac disase
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
15. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
DiGeorge
IgM and IgD
IgA
IgG
16. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
CD21
Innate
Fc
SCID
17. What are the three things you find post splenectomy
Howell - Jolly bodies - Target cells - thrombocytosis
III
Pernicious anemia (to B12 def) - hashimotos thyroiditis
DiGeorge
18. What are the classic example of bacterial antigen variation and the unique mechanims
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
CD40 and CD40L
B cell localization and proliferation
IgG - IgM GM makes classic cars
19. antigliadin - antiendomysial
CD14
Pemphigus vulgaris
Ceilac disase
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
20. antimicrosomal - antithyroglobulin
Hashimotos
Other vasculitidies
C5b -9
All nucleated cells (no RBCs) A - B - C
21. Which cell mediates the type IV hypersens rxn?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Right arm and right half of head
II
CD8 cells
22. Which portion of the antibody determines the isotype
III
Mixed connective tissue disease
Fc
Opsonization - neutralization and complement activation
23. Which parts of the antibody to heavy chain contribute?
RA - DM type 1
Selective Ig def - IgA most common
Macs - dendritic cell - B cell
Fc and Fab
24. Anti Scl 70 (DNA topo I
Autoimmune hepatitis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Scleroderma diffuse
Chronic granulomatous disease
25. Which antibody mediates a type Hypersens rxn?
IgE
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IFN gamma
26. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Stomach
27. Antihistone
Autoimmune hepatitis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Scleroderma CREST
Drug induced lupus
28. anti SS A/B or anti Ro/La
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29. Which lymph node drains the anal canal below
III
Superficial inguinal pectinate line
Fc
Opsonization - neutralization and complement activation
30. What is the unique cell marker for NK cells
Common variable immunodeficiency (CVID)
Ataxia telangectasia
CD56
RA
31. What are the two signals in helper T activation?
MS - hay fever - SLE - goodpasture's
Signal 1 = APC - signal 2 = B7 and CD28
Wegeners granulomatosis
DM type 1
32. What are the 4 T's of type IV hypersense
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Chronic mucocutaneaous candidiasis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
33. Defectin in isotype switching
Secondary
Selective Ig def - IgA most common
IgA
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
34. Which type of hypersens rxn is serum sickness?
III
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
DM type 1
Upper limb and breast
35. Which area of the lymph node englarges in an extreme immune response
Chronic: fibrosis of graft tissue and blood vessels
Goodpastures
Paracortex
APCs - and DR - DP and DQ
36. Anti - IgG (RF)
Opsonization - neutralization and complement activation
RA
Secondary
Il -4
37. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Ataxia telangectasia
DiGeorge
Signal 1 = APC - signal 2 = B7 and CD28
Pemphigus vulgaris
38. What does the Th2 response do?
Hashimotos
Bruton's agamma
Regulates the humoral response
IL-12
39. Deficiency in DAF
Primary biliary cirrohosis
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
40. Antimitochondrial
Help B cells make antibody - secrete IFN gamma to activate macs
Primary biliary cirrohosis
APCs - and DR - DP and DQ
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
41. Which antibody mediates type II and type III hypersens rxn
IL-12
Corticomedullary junction
IL-2 and IFN gamma
IgG
42. Which type of hypersens rxn is antibody mediated?
2
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Perforin - granzyme - granulysin
II
43. Where do positive and negative selection occur in the thymus?
IL-12 def
Hemochromocytosis
Corticomedullary junction
MS - hay fever - SLE - goodpasture's
44. Defect in DNA repair enzymes
Fc and Fab
Ataxia telangectasia
IgM
Howell - Jolly bodies - Target cells - thrombocytosis
45. What kind of hypersens rxn in anaphylaxis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Chediak Higashi
I
2
46. antidesmoglein
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
S. aureus and S. pyogenes
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Pemphigus vulgaris
47. T cell dysfunction
Goodpastures
Bruton's agamma
Upper limb and breast
Chronic mucocutaneaous candidiasis
48. decreased Th1 response
Primary biliary cirrohosis
IL-12 def
Fc
IL-12
49. Cell surface receptors on B cels
IgM
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IgG
Hyperacute : occlusion - ischemia - necrosis
50. Which kind of immunity is germline encoded?
Innate
Hyper IgM
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
III
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