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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Anti - IgG (RF)
DM type 1
RA
Secondary
Right arm and right half of head

2. Which is the receptors for EBV?
CD21
Scleroderma CREST
Superficial inguinal pectinate line
CD40 and CD40L

3. Anticentromere
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Drug induced lupus
Scleroderma CREST
IL-12 - IFN- beta. IFN- alpha

4. Which portion of the antibody determines the isotype
Il -4
Fc
IgM
IV

5. HLA- DR5
Hereditary angioedema
Everything else - not right arm and right half of head
DiGeorge
Pernicious anemia (to B12 def) - hashimotos thyroiditis

6. Deficiency in DAF
MHC II 4 x 2=8
IgE
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Chediak Higashi

7. Which antibody (IgM or IgG) crosses the placenta?
Regulates the humoral response
PMNs recruited by IL-8 to clear infxns
IgG
Selective Ig def - IgA most common

8. Th cells don't produce IFN gamma - no PMN response

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9. Anti Scl 70 (DNA topo I
Common variable immunodeficiency (CVID)
Scleroderma CREST
III
Scleroderma diffuse

10. Which kind of immunity is germline encoded?
DM type 1
Innate
2
IV

11. What does clean up on Aisle 8 stand for?
II
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
PMNs recruited by IL-8 to clear infxns

12. Which complement protein opsonizes bacteria?
Pemphigus vulgaris
C3b
Mixed connective tissue disease
Corticomedullary junction

13. What does the thoracic duct drain?
Everything else - not right arm and right half of head
Corticomedullary junction
Fab
Wegeners granulomatosis

14. Which immunoglobulin is a pentamer
2
II
RA
IgM

15. What do you find in the medulla of the thymus?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Trypanosomes - programmed rearrangement
Hereditary angioedema
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

16. anti glutamate decarboxylase
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Hereditary angioedema
Right arm and right half of head
DM type 1

17. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Wegeners granulomatosis
Right arm and right half of head

18. What are the two signals in helper T activation?
C5b -9
Other vasculitidies
S. aureus and S. pyogenes
Signal 1 = APC - signal 2 = B7 and CD28

19. Defect in DNA repair enzymes
Fab
Pemphigus vulgaris
CD40 and CD40L
Ataxia telangectasia

20. Which parts of the antibody to light chain contribute
IgG
Fab
C3b
IV

21. HLA- B8

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22. What interferes with viruses?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
SCID
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

23. What are the cytokines involved in macrophage/lymphocyte interaction
Bruton's agamma
C5b -9
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

24. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Steroid - responsive nephrotic syndrome

25. What is the role of CD4 cels
Corticomedullary junction
Help B cells make antibody - secrete IFN gamma to activate macs
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Hemochromocytosis

26. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
DM type 1
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

27. anti basement membrane
Goodpastures
IL-12 - IFN- beta. IFN- alpha
Upper limb and breast
Hemochromocytosis

28. HLA- D2

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29. Anti ds DNA - anti Smith
RA
Macs - dendritic cell - B cell
Drug induced lupus
SLE

30. Which type of hypersens rxn is the arthus rxn
IL-4 - 5 - 10
DiGeorge
SCID
III

31. Which complement proteins make up the MAC
II
Hashimotos
C5b -9
CD8 cells

32. What are the 4 T's of type IV hypersense
Selective Ig def - IgA most common
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Everything else - not right arm and right half of head
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

33. What is the difference in antigenic variation in viruses
Major shift minor drift
Primary biliary cirrohosis
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD56

34. anti - Jo 1
Poly/dermato myositis
C5b -9
Adaptive
Neisseria bacteremia

35. Which type of hypersens rxn is delayed
Selective Ig def - IgA most common
Macs - dendritic cell - B cell
IV
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

36. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
Pemphigus vulgaris
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
C3b

37. What does the Th2 response do?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Regulates the humoral response
Macs - dendritic cell - B cell
Mixed connective tissue disease

38. What are the two signals required for B cells class switching?
RA - DM type 1
Hyperacute : occlusion - ischemia - necrosis
CD40 and CD40L
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

39. What is the main function of IgA
IgM
Mesenchyme
Prevents attachment of bacteria and viruses to mucous membranes
Paracortex

40. Defect in CD40L on helper T
Primary biliary cirrohosis
Chediak Higashi
Hyper IgM
Graves' dz

41. How do NK cells kill?
III
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Prevents attachment of bacteria and viruses to mucous membranes
Regulates the humoral response

42. Which cytokine inhibits Th1 cells
IgG
IL-12
Prevents attachment of bacteria and viruses to mucous membranes
IL-10

43. Antihistone
Ceilac disase
C5b -9
Mixed connective tissue disease
Drug induced lupus

44. Antimitochondrial
Primary biliary cirrohosis
Common variable immunodeficiency (CVID)
Wegeners granulomatosis
III

45. Cell surface receptors on B cels
CD56
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Chronic: fibrosis of graft tissue and blood vessels
SLE

46. What are the two signals in cytotoxic T cells activation?
MHC II 4 x 2=8
IL-12 - IFN- beta. IFN- alpha
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Secondary

47. transplant rejection: T cell and antibody mediated vasular damage
CD56
Trypanosomes - programmed rearrangement
Chediak Higashi
Chronic: fibrosis of graft tissue and blood vessels

48. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
SLE
No - peptides only can can be presented on MHC molecules

49. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
Pemphigus vulgaris
Macs - dendritic cell - B cell
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

50. which kind of immunity is characterized by receptors that undergo VDJ recombination?
CD8 cells
C5b -9
Adaptive
APCs - and DR - DP and DQ