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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Th cells don't produce IFN gamma - no PMN response

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2. Which is the receptors for EBV?
CD21
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgG
IgM and IgD

3. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
No - peptides only can can be presented on MHC molecules
Wegeners granulomatosis

4. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
C3b
Prevents attachment of bacteria and viruses to mucous membranes
Mesenchyme

5. Which is the most abundant immunoglobulin in the blood?
CD40 and CD40L
CD8 cells
Chediak Higashi
IgG

6. Which type of hypersens rxn is delayed
MS - hay fever - SLE - goodpasture's
C3b
Primary biliary cirrohosis
IV

7. What does a deficiency in C3 lead to...
Steroid - responsive nephrotic syndrome
Sjorgen's syndrome
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Other vasculitidies

8. transplant rejection: T cell and antibody mediated vasular damage
CD56
Major shift minor drift
Chronic: fibrosis of graft tissue and blood vessels
Selective Ig def - IgA most common

9. What are the 3 funxtions of antibodies?
Perforin - granzyme - granulysin
2
Opsonization - neutralization and complement activation
Chronic: fibrosis of graft tissue and blood vessels

10. HLA- B8

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11. Defect in DNA repair enzymes
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IL-4 - 5 - 10
Ataxia telangectasia
Graves' dz

12. HLA- DR5
Hereditary angioedema
Autoimmune hepatitis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IL-2 and IFN gamma

13. What are the three things you find post splenectomy
Ataxia telangectasia
SCID
MS - hay fever - SLE - goodpasture's
Howell - Jolly bodies - Target cells - thrombocytosis

14. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
Ataxia telangectasia
Sjorgen's syndrome
Pemphigus vulgaris

15. Anti Scl 70 (DNA topo I
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Mixed connective tissue disease
All nucleated cells (no RBCs) A - B - C
Scleroderma diffuse

16. What is the main function of IgA
Prevents attachment of bacteria and viruses to mucous membranes
Regulates the humoral response
II
IgM

17. Which cytokine inhibits Th1 cells
IL-10
Other vasculitidies
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Steroid - responsive nephrotic syndrome

18. What are the 4 T's of type IV hypersense
Sjorgen's syndrome
DM type 1
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

19. Which complement protein opsonizes bacteria?
C3b
Neisseria bacteremia
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Macs - dendritic cell - B cell

20. which follicles (primary or secondary) have active germinal centers?
Secondary
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Steroid - responsive nephrotic syndrome
MHC II 4 x 2=8

21. Which cytokine induces Th1 cell profile in CD4 cells
Pemphigus vulgaris
RA - DM type 1
IL-12
IgM and IgD

22. How many signals are required for T cell activation or B cell class switching?
2
Steroid - responsive nephrotic syndrome
IgG
Chronic granulomatous disease

23. Which MHC complex to CD4 cells bind
CD56
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Pernicious anemia (to B12 def) - hashimotos thyroiditis
MHC II 4 x 2=8

24. What are the two signals in cytotoxic T cells activation?
CD14
Fc
Stomach
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

25. Which kind of immunity is germline encoded?
Hyperacute : occlusion - ischemia - necrosis
Innate
Trypanosomes - programmed rearrangement
Common variable immunodeficiency (CVID)

26. HLA- DR7
Steroid - responsive nephrotic syndrome
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
II
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

27. Where do positive and negative selection occur in the thymus?
Leukocyte adhesion deficiency type 1
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Corticomedullary junction

28. Anticentromere
Right arm and right half of head
Scleroderma CREST
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IgE

29. Defect in B cell maturation
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
SLE
IL-4 - 5 - 10
Common variable immunodeficiency (CVID)

30. decreased Th1 response
IFN gamma
IL-12 def
Hyperacute : occlusion - ischemia - necrosis
Trypanosomes - programmed rearrangement

31. What does clean up on Aisle 8 stand for?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Mesenchyme
Other vasculitidies
PMNs recruited by IL-8 to clear infxns

32. Transplant rejection: preformed host antibody mediated
Bruton's agamma
IFN gamma
Hyper IgE syndrome (Job's)
Hyperacute : occlusion - ischemia - necrosis

33. p - ANCA
Prevents attachment of bacteria and viruses to mucous membranes
IFN gamma
Other vasculitidies
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

34. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Right arm and right half of head
Adaptive
Chediak Higashi

35. Anti ds DNA - anti Smith
Common variable immunodeficiency (CVID)
DiGeorge
SLE
B cell localization and proliferation

36. How are NK cells stimulated?
Major shift minor drift
IL-2 and IFN gamma
IL-12 - IFN- beta. IFN- alpha
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

37. What kind of hypersens rxn in anaphylaxis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Autoimmune hepatitis
I
Graves' dz

38. What are the classic example of bacterial antigen variation and the unique mechanims
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Leukocyte adhesion deficiency type 1
Bruton's agamma

39. Which type of hypersens rxn is serum sickness?
IFN gamma
Mature t cells - epithelial reticular cells - Hassalls corpuscles
III
MS - hay fever - SLE - goodpasture's

40. Which type of hypersens rxn is immune complex mediate
III
DiGeorge
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Mesenchyme

41. What do superantigens do?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Major shift minor drift
Prevents attachment of bacteria and viruses to mucous membranes
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

42. T cell dysfunction
Fc
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Graves' dz
Chronic mucocutaneaous candidiasis

43. What are the two signals in helper T activation?
Signal 1 = APC - signal 2 = B7 and CD28
No - peptides only can can be presented on MHC molecules
Hyper IgM
C3b

44. Which B T cell interaction allows for immunologic memory and class switching?
Fab
CD40 and CD40L
IgG
Regulates the humoral response

45. anti U1 RNP
C5b -9
IL-4 - 5 - 10
Bruton's agamma
Mixed connective tissue disease

46. Which type of hypersens rxn is the arthus rxn
III
Ceilac disase
Right arm and right half of head
IV

47. Which area of the lymph node englarges in an extreme immune response
IL-4 - 5 - 10
Hemochromocytosis
III
Paracortex

48. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Help B cells make antibody - secrete IFN gamma to activate macs
IgA
DiGeorge
III

49. anti SS A/B or anti Ro/La

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50. What are the cell surface receptors on MACS
Drug induced lupus
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IgA
Wegeners granulomatosis