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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. anti - Jo 1
Hemochromocytosis
Poly/dermato myositis
Scleroderma CREST
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

2. Which parasites exhibit antigenic variation
IFN gamma
Trypanosomes - programmed rearrangement
SLE
Chronic granulomatous disease

3. antimicrosomal - antithyroglobulin
IgA
Help B cells make antibody - secrete IFN gamma to activate macs
Macs - dendritic cell - B cell
Hashimotos

4. What are the two signals in helper T activation?
Poly/dermato myositis
DM type 1
Signal 1 = APC - signal 2 = B7 and CD28
Other vasculitidies

5. antidesmoglein
Pemphigus vulgaris
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Common variable immunodeficiency (CVID)

6. anti basement membrane
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IgG
Goodpastures
DM type 1

7. What do you find in the medulla of the thymus?
PMNs recruited by IL-8 to clear infxns
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IL-12 def

8. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
DM type 1
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
III

9. antigliadin - antiendomysial
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
III
Regulates the humoral response
Ceilac disase

10. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Adaptive
Hereditary angioedema
S. aureus and S. pyogenes
No - peptides only can can be presented on MHC molecules

11. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Pemphigus vulgaris
IgA
Opsonization - neutralization and complement activation
PMNs recruited by IL-8 to clear infxns

12. p - ANCA
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Other vasculitidies
Fab
Hyperacute : occlusion - ischemia - necrosis

13. HLA- DR4
RA - DM type 1
Goodpastures
CD14
Hyper IgM

14. What are the two signals required for B cells class switching?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

15. Where do positive and negative selection occur in the thymus?
Hashimotos
Scleroderma diffuse
Corticomedullary junction
Mesenchyme

16. Cell surface receptors on B cels
Leukocyte adhesion deficiency type 1
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Trypanosomes - programmed rearrangement
Drug induced lupus

17. decreased Th1 response
Ataxia telangectasia
IL-12 def
I
Pemphigus vulgaris

18. What are the three things you find post splenectomy
Howell - Jolly bodies - Target cells - thrombocytosis
No - peptides only can can be presented on MHC molecules
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Right arm and right half of head

19. Anti - IgG (RF)
Selective Ig def - IgA most common
RA
CD21
SLE

20. transplant rejection: T cell and antibody mediated vasular damage
Il -4
Autoimmune hepatitis
Chronic: fibrosis of graft tissue and blood vessels
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

21. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
CD14
SCID
IL-12 - IFN- beta. IFN- alpha
Help B cells make antibody - secrete IFN gamma to activate macs

22. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Chronic granulomatous disease
DiGeorge
Trypanosomes - programmed rearrangement

23. HLA- A3
Hemochromocytosis
IV
Stomach
Major shift minor drift

24. HLA- DR7
Chronic granulomatous disease
Howell - Jolly bodies - Target cells - thrombocytosis
Steroid - responsive nephrotic syndrome
Other vasculitidies

25. What does clean up on Aisle 8 stand for?
Sjorgen's syndrome
Corticomedullary junction
Chronic granulomatous disease
PMNs recruited by IL-8 to clear infxns

26. What are the cytokines involved in macrophage/lymphocyte interaction
Scleroderma CREST
Regulates the humoral response
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

27. What kind of hypersens rxn in anaphylaxis
Ceilac disase
I
Help B cells make antibody - secrete IFN gamma to activate macs
2

28. Which complement protein opsonizes bacteria?
C3b
Opsonization - neutralization and complement activation
Goodpastures
Chronic mucocutaneaous candidiasis

29. Which type of hypersens rxn is the arthus rxn
III
PMNs recruited by IL-8 to clear infxns
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

30. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DiGeorge
Drug induced lupus
IgG
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

31. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
SCID
Signal 1 = APC - signal 2 = B7 and CD28
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

32. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
Hyper IgE syndrome (Job's)
I
B cell localization and proliferation

33. Which portion of the antibody determines the isotype
B cell localization and proliferation
Fc
Fc and Fab
Corticomedullary junction

34. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Adaptive
MHC I
SCID

35. Which parts of the antibody to heavy chain contribute?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Fc and Fab
IgG

36. How do NK cells kill?
Major shift minor drift
Goodpastures
Graves' dz
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

37. c - ANCA
IL-12 - IFN- beta. IFN- alpha
Wegeners granulomatosis
IL-4 - 5 - 10
CD56

38. Which lymph node drains the anal canal below
Steroid - responsive nephrotic syndrome
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Superficial inguinal pectinate line
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

39. Which complement proteins make up the MAC
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Stomach
Poly/dermato myositis
C5b -9

40. Which type of hypersens rxn is antibody mediated?
Secondary
II
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgG

41. What interferes with viruses?
Hyper IgM
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Drug induced lupus
IgA

42. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Primary biliary cirrohosis
Scleroderma CREST

43. Transplant rejection: preformed host antibody mediated
DM type 1
Hyperacute : occlusion - ischemia - necrosis
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

44. HLA- DR3
Hyperacute : occlusion - ischemia - necrosis
Mesenchyme
DM type 1
Poly/dermato myositis

45. What are the 4 T's of type IV hypersense
Fc and Fab
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Wegeners granulomatosis
C3b

46. Which B T cell interaction allows for immunologic memory and class switching?
Bruton's agamma
CD40 and CD40L
III
Fc

47. What does a deficiency in C5- C8 lead to?
Right arm and right half of head
Neisseria bacteremia
Fab
Hyperacute : occlusion - ischemia - necrosis

48. Which is the most abundant immunoglobulin in the blood?
Chronic mucocutaneaous candidiasis
IgG
Perforin - granzyme - granulysin
Drug induced lupus

49. What does the thoracic duct drain?
Everything else - not right arm and right half of head
CD14
Drug induced lupus
I

50. Which bacteria secrete superantigen
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
CD8 cells
Hashimotos
S. aureus and S. pyogenes