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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Deficiency in DAF
Scleroderma diffuse
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgG - IgM GM makes classic cars
CD14

2. anti basement membrane
Mesenchyme
Stomach
Goodpastures
IgG

3. Which cytokine inhibits Th1 cells
IL-10
Poly/dermato myositis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Major shift minor drift

4. Which receptor on MACS to endotoxin directy stimulate?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
CD14
Common variable immunodeficiency (CVID)
Pernicious anemia (to B12 def) - hashimotos thyroiditis

5. What embryologic tissue are lymphcytes derived from
Graves' dz
Mesenchyme
Right arm and right half of head
Hyper IgM

6. Defect in DNA repair enzymes
MHC I
B cell localization and proliferation
Ataxia telangectasia
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

7. What are the classic example of bacterial antigen variation and the unique mechanims
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
S. aureus and S. pyogenes
CD8 cells
RA

8. antigliadin - antiendomysial
Hyperacute : occlusion - ischemia - necrosis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Ceilac disase
DiGeorge

9. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Autoimmune hepatitis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgE
SCID

10. Which type of hypersens rxn is antibody mediated?
C3b
II
Howell - Jolly bodies - Target cells - thrombocytosis
Paracortex

11. What do mature B lymphos express on their surface?
Help B cells make antibody - secrete IFN gamma to activate macs
IgM and IgD
Chronic: fibrosis of graft tissue and blood vessels
CD21

12. HLA- DR7
Innate
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Steroid - responsive nephrotic syndrome
C3b

13. Antimitochondrial
S. aureus and S. pyogenes
Goodpastures
Primary biliary cirrohosis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

14. Which is the receptors for EBV?
CD21
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
III
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

15. HLA- D2

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16. T cell dysfunction
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Il -4
Chronic mucocutaneaous candidiasis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

17. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
Everything else - not right arm and right half of head
Opsonization - neutralization and complement activation
Innate

18. Which type of hypersens rxn is immune complex mediate
All nucleated cells (no RBCs) A - B - C
III
Chediak Higashi
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

19. Which cytokine induces Th1 cell profile in CD4 cells
Corticomedullary junction
MS - hay fever - SLE - goodpasture's
IL-12
IgM

20. thwat does the Right lymphatic duct drain?
Right arm and right half of head
DiGeorge
I
C5b -9

21. Which lymph node drains the anal canal below
IgM and IgD
IgG
Superficial inguinal pectinate line
DM type 1

22. What is the difference in antigenic variation in viruses
Major shift minor drift
S. aureus and S. pyogenes
Hyper IgM
III

23. Transplant rejection: preformed host antibody mediated
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Leukocyte adhesion deficiency type 1
IL-4 - 5 - 10
Hyperacute : occlusion - ischemia - necrosis

24. Which antibody mediates type II and type III hypersens rxn
Right arm and right half of head
Hyper IgM
IgG
Fab

25. What is the unique cell marker for NK cells
III
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Major shift minor drift
CD56

26. anti - Jo 1
PMNs recruited by IL-8 to clear infxns
DM type 1
Poly/dermato myositis
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

27. What are the 4 T's of type IV hypersense
RA - DM type 1
Fab
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Chronic granulomatous disease

28. What does the thoracic duct drain?
Everything else - not right arm and right half of head
CD14
IgM and IgD
Pernicious anemia (to B12 def) - hashimotos thyroiditis

29. anti glutamate decarboxylase
DM type 1
Right arm and right half of head
Hyper IgM
Fc

30. Which cell mediates the type IV hypersens rxn?
CD8 cells
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Adaptive
Autoimmune hepatitis

31. X linked recessive defect in BTK no B cell differentiation

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32. What are the two signals required for B cells class switching?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Help B cells make antibody - secrete IFN gamma to activate macs
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

33. Antihistone
Corticomedullary junction
Steroid - responsive nephrotic syndrome
RA
Drug induced lupus

34. p - ANCA
RA - DM type 1
Other vasculitidies
Steroid - responsive nephrotic syndrome
No - peptides only can can be presented on MHC molecules

35. ANA
Graves' dz
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
SLE - nonspecific
CD21

36. Where do positive and negative selection occur in the thymus?
Opsonization - neutralization and complement activation
Corticomedullary junction
Drug induced lupus
CD14

37. How do CD8 cells kill?
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
III
Perforin - granzyme - granulysin
CD8 cells

38. HLA- DR3
IgE
Il -4
DM type 1
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

39. Defect in CD40L on helper T
Graves' dz
CD40 and CD40L
Poly/dermato myositis
Hyper IgM

40. What does a deficiency in C5- C8 lead to?
Poly/dermato myositis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Innate
Neisseria bacteremia

41. What are the three APCs
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Howell - Jolly bodies - Target cells - thrombocytosis
Leukocyte adhesion deficiency type 1
Macs - dendritic cell - B cell

42. Which cytokines to Th1 cells secrete?
IL-2 and IFN gamma
Hashimotos
Ataxia telangectasia
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

43. HLA- DR4
RA - DM type 1
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
All nucleated cells (no RBCs) A - B - C
DM type 1

44. antimicrosomal - antithyroglobulin
Mesenchyme
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hashimotos
IgM and IgD

45. HLA- B8

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46. c - ANCA
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Neisseria bacteremia
Wegeners granulomatosis
Chediak Higashi

47. Which complement protein opsonizes bacteria?
Hashimotos
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
C3b
CD8 cells

48. Anticentromere
Sjorgen's syndrome
Scleroderma CREST
IL-4 - 5 - 10
Stomach

49. Which type of hypersens rxn is delayed
Wegeners granulomatosis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IV
Opsonization - neutralization and complement activation

50. What kind of hypersens rxn in anaphylaxis
Scleroderma CREST
I
Chronic mucocutaneaous candidiasis
Hyper IgM