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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What kind of hypersens rxn in anaphylaxis
I
Poly/dermato myositis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Common variable immunodeficiency (CVID)

2. How do NK cells kill?
CD56
Hyperacute : occlusion - ischemia - necrosis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
No - peptides only can can be presented on MHC molecules

3. Which MHC complex to CD4 cells bind
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
MS - hay fever - SLE - goodpasture's
MHC II 4 x 2=8
Stomach

4. HLA- DR4
RA - DM type 1
IL-12 - IFN- beta. IFN- alpha
IgM and IgD
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

5. Which receptor on MACS to endotoxin directy stimulate?
Upper limb and breast
Chronic granulomatous disease
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
CD14

6. Which cytokine inhibits Th1 cells
IL-10
SLE
Hyper IgM
Hashimotos

7. p - ANCA
APCs - and DR - DP and DQ
Pemphigus vulgaris
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Other vasculitidies

8. What are the classic example of bacterial antigen variation and the unique mechanims
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Scleroderma CREST
IgM
Help B cells make antibody - secrete IFN gamma to activate macs

9. Defect in B cell maturation
Sjorgen's syndrome
All nucleated cells (no RBCs) A - B - C
Common variable immunodeficiency (CVID)
III

10. X linked recessive defect in BTK no B cell differentiation

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11. T cell dysfunction
Regulates the humoral response
Hereditary angioedema
Wegeners granulomatosis
Chronic mucocutaneaous candidiasis

12. What cytokines to Th2 cells secrete?
Mesenchyme
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Prevents attachment of bacteria and viruses to mucous membranes
IL-4 - 5 - 10

13. Which lymph node drains the anal canal below
IL-12
Superficial inguinal pectinate line
IgG
Signal 1 = APC - signal 2 = B7 and CD28

14. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
SCID
B cell localization and proliferation
Secondary
Primary biliary cirrohosis

15. Which bacteria secrete superantigen
Scleroderma CREST
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
S. aureus and S. pyogenes
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

16. HLA- DR5
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Chronic granulomatous disease
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Ceilac disase

17. Which type of hypersens rxn is antibody mediated?
Graves' dz
DiGeorge
II
Everything else - not right arm and right half of head

18. which kind of immunity is characterized by receptors that undergo VDJ recombination?
MHC I
DM type 1
Adaptive
IL-12 - IFN- beta. IFN- alpha

19. What are the two signals required for B cells class switching?
SLE
Stomach
Sjorgen's syndrome
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

20. Which immunoglobulin is a pentamer
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Neisseria bacteremia
IgM
Right arm and right half of head

21. anti SS A/B or anti Ro/La

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22. What does the thoracic duct drain?
Perforin - granzyme - granulysin
Everything else - not right arm and right half of head
IgG
Help B cells make antibody - secrete IFN gamma to activate macs

23. What are the two signals in cytotoxic T cells activation?
IgM and IgD
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Right arm and right half of head

24. Deficiency in DAF
Chronic: fibrosis of graft tissue and blood vessels
Sjorgen's syndrome
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
2

25. antimicrosomal - antithyroglobulin
IL-12
Macs - dendritic cell - B cell
Hashimotos
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

26. Antihistone
Bruton's agamma
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Drug induced lupus

27. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Corticomedullary junction

28. What is the difference in antigenic variation in viruses
Selective Ig def - IgA most common
Mesenchyme
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Major shift minor drift

29. Defect in CD40L on helper T
CD8 cells
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Signal 1 = APC - signal 2 = B7 and CD28
Hyper IgM

30. What does the Th2 response do?
Regulates the humoral response
Hashimotos
DM type 1
IL-2 and IFN gamma

31. What kind of bacteria do macrophages remove from the spleen?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
CD56
Other vasculitidies

32. decreased Th1 response
IL-12 def
DiGeorge
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Pernicious anemia (to B12 def) - hashimotos thyroiditis

33. Defect in LFA-1 integrin CD18 protein on phagocytes
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
SLE
Leukocyte adhesion deficiency type 1
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

34. Which complement protein opsonizes bacteria?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
C3b
IL-12 def
IgA

35. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Bruton's agamma
RA
Perforin - granzyme - granulysin

36. What are the three things you find post splenectomy
RA - DM type 1
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Howell - Jolly bodies - Target cells - thrombocytosis
Goodpastures

37. HLA- B27

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38. Which cytokines to Th1 cells secrete?
IL-2 and IFN gamma
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Il -4
CD40 and CD40L

39. which follicles (primary or secondary) have active germinal centers?
Secondary
Innate
IgG - IgM GM makes classic cars
Other vasculitidies

40. Which cell mediates the type IV hypersens rxn?
All nucleated cells (no RBCs) A - B - C
CD8 cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
SLE - nonspecific

41. Which type of hypersens rxn is delayed
IgG
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
IV

42. What is the unique cell marker for NK cells
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
2
Regulates the humoral response
CD56

43. ANA
C3b
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
III
SLE - nonspecific

44. HLA- A3
Hemochromocytosis
Adaptive
Primary biliary cirrohosis
2

45. Which complement proteins make up the MAC
C5b -9
Fc and Fab
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Secondary

46. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
IL-12 - IFN- beta. IFN- alpha
CD21
RA

47. Defect in DNA repair enzymes
Primary biliary cirrohosis
Ataxia telangectasia
IV
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

48. Which type of hypersens rxn is serum sickness?
Primary biliary cirrohosis
Drug induced lupus
III
Chediak Higashi

49. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Fab
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IV
IgG

50. Which antibody (IgM or IgG) crosses the placenta?
Primary biliary cirrohosis
IgG
Bruton's agamma
CD8 cells