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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Cell surface receptors on B cels
DM type 1
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Selective Ig def - IgA most common
Hyper IgM

2. Which MHC complex to CD4 cells bind
MHC II 4 x 2=8
DM type 1
Bruton's agamma
IL-12 def

3. What inhibits Th2 cells
Other vasculitidies
IgM
IFN gamma
Pernicious anemia (to B12 def) - hashimotos thyroiditis

4. Which receptor on MACS to endotoxin directy stimulate?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgG - IgM GM makes classic cars
CD14
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

5. What does a deficiency in C3 lead to...
III
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgM and IgD

6. HLA- B27

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7. Transplant rejection: preformed host antibody mediated
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Major shift minor drift
Hyperacute : occlusion - ischemia - necrosis
IgE

8. Which cell mediates the type IV hypersens rxn?
IL-10
Poly/dermato myositis
CD8 cells
IL-12 - IFN- beta. IFN- alpha

9. What are the two signals required for B cells class switching?
Perforin - granzyme - granulysin
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

10. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Scleroderma diffuse
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
SLE
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

11. Defect in DNA repair enzymes
All nucleated cells (no RBCs) A - B - C
Ataxia telangectasia
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MHC I

12. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IgA
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

13. which follicles (primary or secondary) have active germinal centers?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Secondary
Howell - Jolly bodies - Target cells - thrombocytosis

14. decreased Th1 response
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IFN gamma
IL-12 def
Everything else - not right arm and right half of head

15. What does the Th2 response do?
Chronic mucocutaneaous candidiasis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Regulates the humoral response
SCID

16. Cell surface receptors on T cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Il -4
IgG
CD40 and CD40L

17. antigliadin - antiendomysial
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Ceilac disase
Macs - dendritic cell - B cell
Other vasculitidies

18. HLA- DR3
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
DM type 1
Chronic: fibrosis of graft tissue and blood vessels

19. Which complement protein opsonizes bacteria?
C3b
Opsonization - neutralization and complement activation
IgG
IgM and IgD

20. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Chediak Higashi
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
No - peptides only can can be presented on MHC molecules
Fc

21. How do NK cells kill?
II
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IgE

22. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
IV
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

23. What does a deficiency in C1 esterase inhibitor lead to?
Steroid - responsive nephrotic syndrome
IgM
Hereditary angioedema
Pernicious anemia (to B12 def) - hashimotos thyroiditis

24. Anti - IgG (RF)
RA
Poly/dermato myositis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
SLE

25. How are NK cells stimulated?
II
IL-12 - IFN- beta. IFN- alpha
Il -4
PMNs recruited by IL-8 to clear infxns

26. Defect in LFA-1 integrin CD18 protein on phagocytes
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Leukocyte adhesion deficiency type 1
C5b -9
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

27. What is the difference in antigenic variation in viruses
III
IgG
Major shift minor drift
CD14

28. transplant rejection: T cell and antibody mediated vasular damage
IFN gamma
Chronic: fibrosis of graft tissue and blood vessels
Superficial inguinal pectinate line
I

29. Which portion of the antibody determines the isotype
Fc
APCs - and DR - DP and DQ
SLE - nonspecific
II

30. What interferes with viruses?
Graves' dz
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Macs - dendritic cell - B cell
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

31. X linked recessive defect in BTK no B cell differentiation

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32. Which type of hypersens rxn is serum sickness?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
III
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Ataxia telangectasia

33. Which areas of the body are drained by the axillary lymph node
C3b
Common variable immunodeficiency (CVID)
Upper limb and breast
SCID

34. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Paracortex
IgG
SCID
Ceilac disase

35. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Corticomedullary junction
B cell localization and proliferation

36. Which type of hypersens rxn is immune complex mediate
IV
Innate
III
Chronic mucocutaneaous candidiasis

37. What are the classic example of bacterial antigen variation and the unique mechanims
Graves' dz
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
RA

38. Antimitochondrial
Mixed connective tissue disease
Ceilac disase
I
Primary biliary cirrohosis

39. Which type of hypersens rxn is the arthus rxn
III
Major shift minor drift
Signal 1 = APC - signal 2 = B7 and CD28
Help B cells make antibody - secrete IFN gamma to activate macs

40. What cytokines to Th2 cells secrete?
Howell - Jolly bodies - Target cells - thrombocytosis
IL-4 - 5 - 10
CD56
IgE

41. antidesmoglein
Pemphigus vulgaris
DM type 1
Fc and Fab
Neisseria bacteremia

42. Which antibodies activate the classic pathway
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IgG - IgM GM makes classic cars
CD8 cells
Mature t cells - epithelial reticular cells - Hassalls corpuscles

43. anti SS A/B or anti Ro/La

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44. What do superantigens do?
IL-12 def
Neisseria bacteremia
Other vasculitidies
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

45. Which cytokines to Th1 cells secrete?
Fc and Fab
Selective Ig def - IgA most common
Il -4
IL-2 and IFN gamma

46. What happens in the follicle of the lymph node
B cell localization and proliferation
IgE
Other vasculitidies
Chronic mucocutaneaous candidiasis

47. What embryologic tissue are lymphcytes derived from
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Chronic granulomatous disease
Mesenchyme
Mixed connective tissue disease

48. c - ANCA
Wegeners granulomatosis
Primary biliary cirrohosis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IgG

49. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Mixed connective tissue disease
Primary biliary cirrohosis
DiGeorge
Neisseria bacteremia

50. Which is the most abundant immunoglobulin in the blood?
IgG
All nucleated cells (no RBCs) A - B - C
2
Wegeners granulomatosis