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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. HLA- D2

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2. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Signal 1 = APC - signal 2 = B7 and CD28
MHC I

3. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Bruton's agamma
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
DiGeorge
III

4. Which MHC complex to CD8 cells bind
IV
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Signal 1 = APC - signal 2 = B7 and CD28
MHC I

5. Which antibody mediates a type Hypersens rxn?
Fc
Chronic granulomatous disease
Mixed connective tissue disease
IgE

6. What is the unique cell marker for NK cells
CD56
Fab
IL-12 def
Mature t cells - epithelial reticular cells - Hassalls corpuscles

7. How do NK cells kill?
Hyper IgM
III
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Hashimotos

8. What are the 3 funxtions of antibodies?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Opsonization - neutralization and complement activation
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Hyper IgE syndrome (Job's)

9. Which parasites exhibit antigenic variation
Trypanosomes - programmed rearrangement
Adaptive
IV
Ataxia telangectasia

10. Defectin in isotype switching
III
Il -4
SLE - nonspecific
Selective Ig def - IgA most common

11. What do superantigens do?
S. aureus and S. pyogenes
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-12
IgG

12. What is the arthus rxn?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Hyperacute : occlusion - ischemia - necrosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

13. HLA- A3
Selective Ig def - IgA most common
Hemochromocytosis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
RA - DM type 1

14. p - ANCA
Innate
Other vasculitidies
I
CD21

15. Which cytokines to Th1 cells secrete?
Regulates the humoral response
III
Mesenchyme
IL-2 and IFN gamma

16. Which lymph node drains the anal canal below
Il -4
Hashimotos
Superficial inguinal pectinate line
III

17. Cell surface receptors on B cels
IL-12
CD40 and CD40L
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Hyperacute : occlusion - ischemia - necrosis

18. What is the role of CD4 cels
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
CD56
Help B cells make antibody - secrete IFN gamma to activate macs
No - peptides only can can be presented on MHC molecules

19. Which cell mediates the type IV hypersens rxn?
IgM
Howell - Jolly bodies - Target cells - thrombocytosis
Help B cells make antibody - secrete IFN gamma to activate macs
CD8 cells

20. What are the two signals in cytotoxic T cells activation?
Hereditary angioedema
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Hyperacute : occlusion - ischemia - necrosis

21. Which type of hypersens rxn is immune complex mediate
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
III
Mature t cells - epithelial reticular cells - Hassalls corpuscles
All nucleated cells (no RBCs) A - B - C

22. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Corticomedullary junction

23. Which is the most abundant immunoglobulin in the blood?
Primary biliary cirrohosis
IgG
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
SLE - nonspecific

24. What does clean up on Aisle 8 stand for?
III
PMNs recruited by IL-8 to clear infxns
Innate
Other vasculitidies

25. decreased Th1 response
MHC I
C5b -9
I
IL-12 def

26. X linked recessive defect in BTK no B cell differentiation

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27. Which is the receptors for EBV?
All nucleated cells (no RBCs) A - B - C
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
CD21
DM type 1

28. HLA- DR5
IgG
IgG
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

29. X- linked recessive defect with progessive deletion of B and T cells
Right arm and right half of head
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

30. Which infections require administering passive immunity?
II
Mesenchyme
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgG

31. thwat does the Right lymphatic duct drain?
Fc
Mesenchyme
Right arm and right half of head
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

32. Transplant rejection: preformed host antibody mediated
Mixed connective tissue disease
Hyperacute : occlusion - ischemia - necrosis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Perforin - granzyme - granulysin

33. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Autoimmune hepatitis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Graves' dz

34. What interferes with viruses?
Stomach
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
SLE
IgA

35. What does a deficiency in C1 esterase inhibitor lead to?
III
Hereditary angioedema
Autoimmune hepatitis
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

36. What does a deficiency in C5- C8 lead to?
Major shift minor drift
No - peptides only can can be presented on MHC molecules
Ataxia telangectasia
Neisseria bacteremia

37. Defect in LFA-1 integrin CD18 protein on phagocytes
B cell localization and proliferation
Primary biliary cirrohosis
Secondary
Leukocyte adhesion deficiency type 1

38. antimicrosomal - antithyroglobulin
I
Hashimotos
SCID
Superficial inguinal pectinate line

39. Anticentromere
Hyper IgE syndrome (Job's)
Mixed connective tissue disease
Scleroderma CREST
SLE

40. Which type of hypersens rxn is antibody mediated?
II
IL-4 - 5 - 10
IgM and IgD
CD56

41. How do CD8 cells kill?
Perforin - granzyme - granulysin
PMNs recruited by IL-8 to clear infxns
Upper limb and breast
Chronic mucocutaneaous candidiasis

42. T cell dysfunction
Chronic mucocutaneaous candidiasis
Hashimotos
IgG
Pemphigus vulgaris

43. Which areas of the body are drained by the axillary lymph node
MHC I
Perforin - granzyme - granulysin
Upper limb and breast
Howell - Jolly bodies - Target cells - thrombocytosis

44. Deficiency in DAF
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Help B cells make antibody - secrete IFN gamma to activate macs
Trypanosomes - programmed rearrangement

45. HLA- DR3
Other vasculitidies
Neisseria bacteremia
DM type 1
Chronic granulomatous disease

46. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
SLE - nonspecific
Chronic granulomatous disease
Wegeners granulomatosis

47. What is the main function of IgA
Corticomedullary junction
Prevents attachment of bacteria and viruses to mucous membranes
RA
Poly/dermato myositis

48. antismooth muscle
Autoimmune hepatitis
CD56
MHC I
CD40 and CD40L

49. Th cells don't produce IFN gamma - no PMN response

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50. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Bruton's agamma
Common variable immunodeficiency (CVID)