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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. anti SS A/B or anti Ro/La

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2. Which kind of immunity is germline encoded?
Innate
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
II

3. Which cytokine inhibits Th1 cells
Pemphigus vulgaris
DM type 1
IL-10
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

4. What do superantigens do?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Scleroderma diffuse
Hereditary angioedema

5. What do mature B lymphos express on their surface?
Graves' dz
RA
Innate
IgM and IgD

6. What does a deficiency in C3 lead to...
IgG
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Everything else - not right arm and right half of head
IL-12 def

7. transplant rejection: T cell and antibody mediated vasular damage
RA
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
III
Chronic: fibrosis of graft tissue and blood vessels

8. What are the two signals in helper T activation?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Signal 1 = APC - signal 2 = B7 and CD28
Hereditary angioedema
Wegeners granulomatosis

9. What are the 4 T's of type IV hypersense
Fab
CD8 cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

10. Defect in DNA repair enzymes
Paracortex
Ataxia telangectasia
IgG
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

11. Transplant rejection: preformed host antibody mediated
Il -4
Prevents attachment of bacteria and viruses to mucous membranes
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Hyperacute : occlusion - ischemia - necrosis

12. antigliadin - antiendomysial
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Right arm and right half of head
Ceilac disase
Signal 1 = APC - signal 2 = B7 and CD28

13. Which lymph node drains the anal canal below
Chronic mucocutaneaous candidiasis
DM type 1
Superficial inguinal pectinate line
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

14. What is the main function of IgA
Autoimmune hepatitis
Upper limb and breast
Mixed connective tissue disease
Prevents attachment of bacteria and viruses to mucous membranes

15. antidesmoglein
Chediak Higashi
Pemphigus vulgaris
Regulates the humoral response
Opsonization - neutralization and complement activation

16. anti glutamate decarboxylase
IgG
DiGeorge
DM type 1
II

17. X linked recessive defect in BTK no B cell differentiation

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18. What are the three APCs
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Macs - dendritic cell - B cell
Primary biliary cirrohosis

19. Anti - IgG (RF)
Scleroderma CREST
Signal 1 = APC - signal 2 = B7 and CD28
Leukocyte adhesion deficiency type 1
RA

20. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgA
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

21. Which parts of the antibody to light chain contribute
IL-4 - 5 - 10
Corticomedullary junction
Fab
Hyper IgM

22. Which is the most abundant immunoglobulin in the blood?
III
IgG
IgE
Upper limb and breast

23. What are the three things you find post splenectomy
Adaptive
Fc and Fab
Opsonization - neutralization and complement activation
Howell - Jolly bodies - Target cells - thrombocytosis

24. Which complement proteins make up the MAC
C5b -9
IgA
Howell - Jolly bodies - Target cells - thrombocytosis
Superficial inguinal pectinate line

25. Defect in B cell maturation
IgG
IL-12 - IFN- beta. IFN- alpha
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Common variable immunodeficiency (CVID)

26. Which complement protein opsonizes bacteria?
C3b
Hemochromocytosis
Right arm and right half of head
IgG

27. Which cytokine induces Th1 cell profile in CD4 cells
Fc
Opsonization - neutralization and complement activation
IgM
IL-12

28. How are NK cells stimulated?
C3b
Sjorgen's syndrome
IL-12 - IFN- beta. IFN- alpha
Trypanosomes - programmed rearrangement

29. How do CD8 cells kill?
III
SLE - nonspecific
IgM
Perforin - granzyme - granulysin

30. HLA- B8

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31. anti basement membrane
Goodpastures
2
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Right arm and right half of head

32. Which area of the lymph node englarges in an extreme immune response
DiGeorge
C3b
Paracortex
IL-12

33. Which antibodies activate the classic pathway
Chronic granulomatous disease
Scleroderma diffuse
IgG - IgM GM makes classic cars
Perforin - granzyme - granulysin

34. Which is the receptors for EBV?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
CD21
C5b -9
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

35. What are the 3 funxtions of antibodies?
Mesenchyme
No - peptides only can can be presented on MHC molecules
Chediak Higashi
Opsonization - neutralization and complement activation

36. What kind of hypersens rxn in anaphylaxis
SCID
Ataxia telangectasia
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
I

37. What does a deficiency in C5- C8 lead to?
Il -4
Neisseria bacteremia
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Everything else - not right arm and right half of head

38. What does clean up on Aisle 8 stand for?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Upper limb and breast
PMNs recruited by IL-8 to clear infxns
Perforin - granzyme - granulysin

39. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
DiGeorge
Bruton's agamma
SCID
DM type 1

40. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
MS - hay fever - SLE - goodpasture's
Autoimmune hepatitis

41. What does a deficiency in C1 esterase inhibitor lead to?
Hereditary angioedema
IgM and IgD
DM type 1
IgG

42. Which type of hypersens rxn is the arthus rxn
Chronic granulomatous disease
III
Fc
SLE

43. Antihistone
DM type 1
Drug induced lupus
Upper limb and breast
C3b

44. Deficiency in DAF
Ceilac disase
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
DM type 1
Scleroderma diffuse

45. What are the classic example of bacterial antigen variation and the unique mechanims
Stomach
Steroid - responsive nephrotic syndrome
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

46. c - ANCA
Right arm and right half of head
Wegeners granulomatosis
Hemochromocytosis
IgA

47. Th cells don't produce IFN gamma - no PMN response

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48. Which parts of the antibody to heavy chain contribute?
Hyper IgM
Fc and Fab
MS - hay fever - SLE - goodpasture's
MHC II 4 x 2=8

49. What is the difference in antigenic variation in viruses
Drug induced lupus
Major shift minor drift
Sjorgen's syndrome
Il -4

50. Defect in LFA-1 integrin CD18 protein on phagocytes
Steroid - responsive nephrotic syndrome
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Leukocyte adhesion deficiency type 1
Opsonization - neutralization and complement activation