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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What does the Th2 response do?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Selective Ig def - IgA most common
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Regulates the humoral response

2. Which complement proteins make up the MAC
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Signal 1 = APC - signal 2 = B7 and CD28
IFN gamma
C5b -9

3. Which type of hypersens rxn is serum sickness?
Right arm and right half of head
III
IgM
IgG - IgM GM makes classic cars

4. Cell surface receptors on T cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IV
Mesenchyme

5. HLA- DR7
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Steroid - responsive nephrotic syndrome
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Macs - dendritic cell - B cell

6. Where is MHC II expressed and and which HLA molecules codes for it
CD56
APCs - and DR - DP and DQ
Drug induced lupus
Hyper IgE syndrome (Job's)

7. Which complement protein opsonizes bacteria?
C3b
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Bruton's agamma
Chronic: fibrosis of graft tissue and blood vessels

8. antidesmoglein
Ceilac disase
Other vasculitidies
Pemphigus vulgaris
Hyperacute : occlusion - ischemia - necrosis

9. What do mature B lymphos express on their surface?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IgM and IgD
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Bruton's agamma

10. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Common variable immunodeficiency (CVID)
IL-10
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

11. What do you find in the medulla of the thymus?
Mesenchyme
Hyperacute : occlusion - ischemia - necrosis
Opsonization - neutralization and complement activation
Mature t cells - epithelial reticular cells - Hassalls corpuscles

12. Where is MHC I expressed - and which HLA molecules code for it
SLE
All nucleated cells (no RBCs) A - B - C
Corticomedullary junction
Scleroderma diffuse

13. antigliadin - antiendomysial
Right arm and right half of head
Major shift minor drift
Ceilac disase
Common variable immunodeficiency (CVID)

14. ANA
SLE - nonspecific
III
C5b -9
Wegeners granulomatosis

15. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Common variable immunodeficiency (CVID)
Chronic granulomatous disease
B cell localization and proliferation

16. X- linked recessive defect with progessive deletion of B and T cells
CD8 cells
MHC II 4 x 2=8
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
MHC I

17. Which antibody mediates type II and type III hypersens rxn
IgG
Hashimotos
Chronic granulomatous disease
MHC I

18. Which infections require administering passive immunity?
Other vasculitidies
IL-12
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Howell - Jolly bodies - Target cells - thrombocytosis

19. Anti - IgG (RF)
IL-4 - 5 - 10
MHC I
Macs - dendritic cell - B cell
RA

20. What are the classic example of bacterial antigen variation and the unique mechanims
Upper limb and breast
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Chronic granulomatous disease
Hemochromocytosis

21. What does a deficiency in C3 lead to...
IL-12 - IFN- beta. IFN- alpha
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IgM and IgD
IgG - IgM GM makes classic cars

22. How do NK cells kill?
Mixed connective tissue disease
Primary biliary cirrohosis
IgA
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

23. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Stomach
Superficial inguinal pectinate line
Hyper IgE syndrome (Job's)
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

24. HLA- DR4
CD14
Poly/dermato myositis
RA - DM type 1
Bruton's agamma

25. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Chronic mucocutaneaous candidiasis
CD8 cells

26. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DM type 1
Hyper IgM
DiGeorge
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

27. which follicles (primary or secondary) have active germinal centers?
III
Primary biliary cirrohosis
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Secondary

28. What inhibits Th2 cells
IFN gamma
APCs - and DR - DP and DQ
Sjorgen's syndrome
Prevents attachment of bacteria and viruses to mucous membranes

29. What is the main function of IgA
IL-10
Prevents attachment of bacteria and viruses to mucous membranes
Perforin - granzyme - granulysin
C5b -9

30. anti - Jo 1
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Chronic: fibrosis of graft tissue and blood vessels
Poly/dermato myositis
III

31. Which receptor on MACS to endotoxin directy stimulate?
Innate
IL-10
CD14
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

32. Which antibody mediates a type Hypersens rxn?
Right arm and right half of head
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgE
IgG - IgM GM makes classic cars

33. Deficiency in DAF
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgM and IgD
Chronic: fibrosis of graft tissue and blood vessels
Wegeners granulomatosis

34. anti SS A/B or anti Ro/La

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35. Which antibody (IgM or IgG) crosses the placenta?
Scleroderma diffuse
IL-12 def
IgG
Il -4

36. antismooth muscle
Autoimmune hepatitis
Fc
IgE
Sjorgen's syndrome

37. HLA- DR5
IgG
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Secondary
MHC II 4 x 2=8

38. Which immunoglobulin is a pentamer
Hyper IgM
IgM
IgG
C3b

39. Th cells don't produce IFN gamma - no PMN response

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40. What does a deficiency in C5- C8 lead to?
Neisseria bacteremia
Major shift minor drift
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
MHC II 4 x 2=8

41. Which parts of the antibody to light chain contribute
IL-12
Other vasculitidies
Mesenchyme
Fab

42. What does HOT- T- Bone stEAk stand for?
Opsonization - neutralization and complement activation
Right arm and right half of head
RA - DM type 1
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

43. Which is the most abundant immunoglobulin in the blood?
Hashimotos
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Hereditary angioedema
IgG

44. HLA- B8

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45. Which B T cell interaction allows for immunologic memory and class switching?
Fc and Fab
CD40 and CD40L
B cell localization and proliferation
IL-12 def

46. Defect in DNA repair enzymes
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Secondary
Ataxia telangectasia
Hemochromocytosis

47. Which kind of immunity is germline encoded?
Mixed connective tissue disease
IL-4 - 5 - 10
Innate
Chronic mucocutaneaous candidiasis

48. Transplant rejection: preformed host antibody mediated
Fc and Fab
Chronic: fibrosis of graft tissue and blood vessels
Graves' dz
Hyperacute : occlusion - ischemia - necrosis

49. decreased Th1 response
Everything else - not right arm and right half of head
IL-12 def
CD56
SLE

50. Which parasites exhibit antigenic variation
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Hyperacute : occlusion - ischemia - necrosis
IgE
Trypanosomes - programmed rearrangement