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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which MHC complex to CD8 cells bind
IgA
DiGeorge
DM type 1
MHC I

2. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Perforin - granzyme - granulysin
Hyper IgE syndrome (Job's)
DM type 1

3. Which B T cell interaction allows for immunologic memory and class switching?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
CD40 and CD40L
SLE - nonspecific
Primary biliary cirrohosis

4. What are the 4 T's of type IV hypersense
Upper limb and breast
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgG
Hyperacute : occlusion - ischemia - necrosis

5. X- linked recessive defect with progessive deletion of B and T cells
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Adaptive
IgG - IgM GM makes classic cars

6. X linked recessive defect in BTK no B cell differentiation

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7. What is the unique cell marker for NK cells
CD56
III
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Autoimmune hepatitis

8. HLA- DR4
RA - DM type 1
S. aureus and S. pyogenes
Fc and Fab
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

9. What kind of bacteria do macrophages remove from the spleen?
IgG
S. aureus and S. pyogenes
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

10. How are NK cells stimulated?
IgE
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IL-12 - IFN- beta. IFN- alpha
RA - DM type 1

11. What does a deficiency in C5- C8 lead to?
MHC II 4 x 2=8
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IL-4 - 5 - 10
Neisseria bacteremia

12. p - ANCA
IgM and IgD
Selective Ig def - IgA most common
Other vasculitidies
Sjorgen's syndrome

13. What is the clinical picture for serum sickness?
Other vasculitidies
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Trypanosomes - programmed rearrangement
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

14. anti - Jo 1
IL-12 - IFN- beta. IFN- alpha
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Howell - Jolly bodies - Target cells - thrombocytosis
Poly/dermato myositis

15. Which type of hypersens rxn is the arthus rxn
S. aureus and S. pyogenes
Major shift minor drift
III
II

16. Which cell mediates the type IV hypersens rxn?
Trypanosomes - programmed rearrangement
All nucleated cells (no RBCs) A - B - C
CD8 cells
Chediak Higashi

17. HLA- B27

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18. antigliadin - antiendomysial
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Adaptive
IL-4 - 5 - 10
Ceilac disase

19. What are the two signals in cytotoxic T cells activation?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Steroid - responsive nephrotic syndrome
PMNs recruited by IL-8 to clear infxns
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

20. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
Ataxia telangectasia
Goodpastures
Poly/dermato myositis

21. HLA- DR3
Graves' dz
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Macs - dendritic cell - B cell
DM type 1

22. Anticentromere
Scleroderma CREST
CD8 cells
Stomach
MHC I

23. ANA
SLE - nonspecific
S. aureus and S. pyogenes
2
MS - hay fever - SLE - goodpasture's

24. What does the Th2 response do?
DiGeorge
C3b
Hashimotos
Regulates the humoral response

25. What is the arthus rxn?
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IgE
IL-10
CD14

26. What are the 3 funxtions of antibodies?
Il -4
Opsonization - neutralization and complement activation
Autoimmune hepatitis
DM type 1

27. What are the two signals required for B cells class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IgG
Macs - dendritic cell - B cell

28. Anti ds DNA - anti Smith
Trypanosomes - programmed rearrangement
SLE
All nucleated cells (no RBCs) A - B - C
Major shift minor drift

29. What does a deficiency in C1 esterase inhibitor lead to?
C3b
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Hereditary angioedema
PMNs recruited by IL-8 to clear infxns

30. Defectin in isotype switching
Il -4
MHC II 4 x 2=8
RA
Selective Ig def - IgA most common

31. Anti Scl 70 (DNA topo I
IFN gamma
Scleroderma diffuse
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Chronic granulomatous disease

32. anti U1 RNP
Sjorgen's syndrome
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Mixed connective tissue disease
MS - hay fever - SLE - goodpasture's

33. anti SS A/B or anti Ro/La

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34. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Fc
PMNs recruited by IL-8 to clear infxns
RA - DM type 1
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

35. anti glutamate decarboxylase
CD14
IgE
Fc and Fab
DM type 1

36. Which antibody mediates a type Hypersens rxn?
IgE
Howell - Jolly bodies - Target cells - thrombocytosis
B cell localization and proliferation
IgM

37. What is the difference in antigenic variation in viruses
Major shift minor drift
Scleroderma diffuse
CD56
CD21

38. Which MHC complex to CD4 cells bind
IL-4 - 5 - 10
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
2
MHC II 4 x 2=8

39. Which type of hypersens rxn is immune complex mediate
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
III
Il -4
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

40. HLA- D2

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41. What kind of hypersens rxn in anaphylaxis
Paracortex
I
IgA
Upper limb and breast

42. What are the three things you find post splenectomy
Hyper IgM
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Howell - Jolly bodies - Target cells - thrombocytosis
IL-12 def

43. Which type of hypersens rxn is delayed
IV
IgM and IgD
Hashimotos
Wegeners granulomatosis

44. What happens in the follicle of the lymph node
Paracortex
Opsonization - neutralization and complement activation
B cell localization and proliferation
Signal 1 = APC - signal 2 = B7 and CD28

45. HLA- A3
Hemochromocytosis
Bruton's agamma
Stomach
Adaptive

46. anti basement membrane
Paracortex
Macs - dendritic cell - B cell
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Goodpastures

47. Which areas of the body are drained by the axillary lymph node
Opsonization - neutralization and complement activation
Upper limb and breast
DiGeorge
Corticomedullary junction

48. HLA- DR7
Steroid - responsive nephrotic syndrome
CD8 cells
No - peptides only can can be presented on MHC molecules
Bruton's agamma

49. Which kind of immunity is germline encoded?
Fab
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Innate
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

50. What are the classic example of bacterial antigen variation and the unique mechanims
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Paracortex
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure