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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. X linked recessive defect in BTK no B cell differentiation

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2. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Hyper IgM
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
DiGeorge
IL-4 - 5 - 10

3. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Mixed connective tissue disease
III
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Prevents attachment of bacteria and viruses to mucous membranes

4. How do CD8 cells kill?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Perforin - granzyme - granulysin
Pernicious anemia (to B12 def) - hashimotos thyroiditis
No - peptides only can can be presented on MHC molecules

5. Which antibody mediates type II and type III hypersens rxn
Hemochromocytosis
Hereditary angioedema
IgG
Paracortex

6. What does a deficiency in C3 lead to...
Everything else - not right arm and right half of head
Howell - Jolly bodies - Target cells - thrombocytosis
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IgA

7. What is the difference in antigenic variation in viruses
Major shift minor drift
Mixed connective tissue disease
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Stomach

8. Cell surface receptors on T cells
DM type 1
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Steroid - responsive nephrotic syndrome
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

9. What are the cytokines involved in macrophage/lymphocyte interaction
Hashimotos
IL-12 def
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

10. Which complement protein opsonizes bacteria?
IgA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Hyper IgM
C3b

11. Which lymph node drains the anal canal below
Scleroderma CREST
Superficial inguinal pectinate line
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

12. which areas of the body are drained by the celiac lymph node?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Neisseria bacteremia
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Stomach

13. AR - defect in microtubule fxn with decreased phagocytosis
IgG
Chediak Higashi
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Hyperacute : occlusion - ischemia - necrosis

14. p - ANCA
Other vasculitidies
B cell localization and proliferation
Hyper IgE syndrome (Job's)
CD21

15. What are the three APCs
All nucleated cells (no RBCs) A - B - C
Common variable immunodeficiency (CVID)
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Macs - dendritic cell - B cell

16. Anticentromere
Scleroderma diffuse
CD14
Drug induced lupus
Scleroderma CREST

17. Where do positive and negative selection occur in the thymus?
Corticomedullary junction
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-2 and IFN gamma
SLE - nonspecific

18. What does a deficiency in C5- C8 lead to?
Other vasculitidies
Neisseria bacteremia
IL-12
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

19. HLA- DR3
DM type 1
Hyperacute : occlusion - ischemia - necrosis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Sjorgen's syndrome

20. What is the main function of IgA
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
C3b
Prevents attachment of bacteria and viruses to mucous membranes

21. Which portion of the antibody determines the isotype
IgE
Fc
Everything else - not right arm and right half of head
Right arm and right half of head

22. Antimitochondrial
Primary biliary cirrohosis
Stomach
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
CD8 cells

23. What are the classic example of bacterial antigen variation and the unique mechanims
APCs - and DR - DP and DQ
Hashimotos
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Fc

24. thwat does the Right lymphatic duct drain?
MHC II 4 x 2=8
Right arm and right half of head
II
RA - DM type 1

25. anti SS A/B or anti Ro/La

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26. What is the arthus rxn?
IgG
IL-12 - IFN- beta. IFN- alpha
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
MHC I

27. What happens in the follicle of the lymph node
B cell localization and proliferation
Neisseria bacteremia
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

28. Which antibodies activate the classic pathway
CD8 cells
Upper limb and breast
Paracortex
IgG - IgM GM makes classic cars

29. What are the 4 T's of type IV hypersense
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IgG - IgM GM makes classic cars
Selective Ig def - IgA most common
CD21

30. c - ANCA
III
Wegeners granulomatosis
CD56
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

31. Which bacteria secrete superantigen
S. aureus and S. pyogenes
Signal 1 = APC - signal 2 = B7 and CD28
III
Right arm and right half of head

32. What is the unique cell marker for NK cells
CD56
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
C3b
DM type 1

33. What are the three things you find post splenectomy
C5b -9
IL-10
Steroid - responsive nephrotic syndrome
Howell - Jolly bodies - Target cells - thrombocytosis

34. What does the Th2 response do?
Paracortex
II
Regulates the humoral response
Trypanosomes - programmed rearrangement

35. Which receptor on MACS to endotoxin directy stimulate?
CD14
Mesenchyme
IgG
IgG - IgM GM makes classic cars

36. transplant rejection: T cell and antibody mediated vasular damage
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Hashimotos
Everything else - not right arm and right half of head
Chronic: fibrosis of graft tissue and blood vessels

37. Antihistone
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IgA
Drug induced lupus
IgG

38. What are the two signals required for B cells class switching?
DiGeorge
Fab
Chronic: fibrosis of graft tissue and blood vessels
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

39. What does HOT- T- Bone stEAk stand for?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Sjorgen's syndrome
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
MS - hay fever - SLE - goodpasture's

40. What are the cell surface receptors on MACS
DM type 1
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
DM type 1
Chediak Higashi

41. which follicles (primary or secondary) have active germinal centers?
IL-12 def
Secondary
Scleroderma diffuse
Graves' dz

42. anti glutamate decarboxylase
Adaptive
DM type 1
IL-4 - 5 - 10
IgA

43. What do mature B lymphos express on their surface?
Paracortex
SLE
IgM and IgD
Secondary

44. Which cytokines to Th1 cells secrete?
IgG
IL-2 and IFN gamma
Poly/dermato myositis
Right arm and right half of head

45. Transplant rejection: preformed host antibody mediated
Innate
Pemphigus vulgaris
Corticomedullary junction
Hyperacute : occlusion - ischemia - necrosis

46. What cytokines to Th2 cells secrete?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
DiGeorge
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-4 - 5 - 10

47. Anti Scl 70 (DNA topo I
Scleroderma diffuse
SLE
Mesenchyme
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

48. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
DM type 1
S. aureus and S. pyogenes
Regulates the humoral response
Chronic granulomatous disease

49. What do superantigens do?
Drug induced lupus
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgG

50. Which is the receptors for EBV?
Neisseria bacteremia
CD21
IgA
Upper limb and breast