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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which antibody (IgM or IgG) crosses the placenta?
APCs - and DR - DP and DQ
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
DM type 1
IgG

2. Which cytokine inhibits Th1 cells
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
CD8 cells
Everything else - not right arm and right half of head
IL-10

3. Which kind of immunity is germline encoded?
Innate
APCs - and DR - DP and DQ
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Goodpastures

4. What inhibits Th2 cells
IFN gamma
Leukocyte adhesion deficiency type 1
IL-12
IL-2 and IFN gamma

5. What kind of bacteria do macrophages remove from the spleen?
B cell localization and proliferation
Primary biliary cirrohosis
Scleroderma CREST
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

6. anti basement membrane
Goodpastures
Right arm and right half of head
III
Corticomedullary junction

7. What does the thoracic duct drain?
Signal 1 = APC - signal 2 = B7 and CD28
Selective Ig def - IgA most common
Everything else - not right arm and right half of head
Drug induced lupus

8. Which cytokines to Th1 cells secrete?
IL-2 and IFN gamma
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Right arm and right half of head
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

9. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
Chronic mucocutaneaous candidiasis
No - peptides only can can be presented on MHC molecules
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Major shift minor drift

10. What are the two signals in cytotoxic T cells activation?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
IL-2 and IFN gamma
Howell - Jolly bodies - Target cells - thrombocytosis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

11. Which bacteria secrete superantigen
IL-12
S. aureus and S. pyogenes
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Macs - dendritic cell - B cell

12. Which parts of the antibody to heavy chain contribute?
IL-2 and IFN gamma
Fc and Fab
Scleroderma CREST
Regulates the humoral response

13. What does HOT- T- Bone stEAk stand for?
IgG
Chronic granulomatous disease
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

14. Which type of hypersens rxn is the arthus rxn
III
Right arm and right half of head
Hyper IgE syndrome (Job's)
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

15. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Secondary
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
MS - hay fever - SLE - goodpasture's

16. HLA- D2

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17. Which type of hypersens rxn is immune complex mediate
Mesenchyme
III
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Pemphigus vulgaris

18. HLA- A3
Hemochromocytosis
MS - hay fever - SLE - goodpasture's
Hashimotos
PMNs recruited by IL-8 to clear infxns

19. Which MHC complex to CD8 cells bind
MHC I
Hashimotos
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

20. What is the clinical picture for serum sickness?
II
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Common variable immunodeficiency (CVID)
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

21. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Prevents attachment of bacteria and viruses to mucous membranes
Poly/dermato myositis
SCID

22. antimicrosomal - antithyroglobulin
Hyper IgM
Macs - dendritic cell - B cell
Hashimotos
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

23. ANA
SLE - nonspecific
Adaptive
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Hyper IgE syndrome (Job's)

24. HLA- DR3
Common variable immunodeficiency (CVID)
CD21
2
DM type 1

25. Which cell mediates the type IV hypersens rxn?
APCs - and DR - DP and DQ
Superficial inguinal pectinate line
Fc
CD8 cells

26. What do mature B lymphos express on their surface?
III
Bruton's agamma
IgM and IgD
SLE

27. What does clean up on Aisle 8 stand for?
Superficial inguinal pectinate line
Help B cells make antibody - secrete IFN gamma to activate macs
PMNs recruited by IL-8 to clear infxns
S. aureus and S. pyogenes

28. Which area of the lymph node englarges in an extreme immune response
Paracortex
Autoimmune hepatitis
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

29. p - ANCA
Other vasculitidies
IgG
Sjorgen's syndrome
Bruton's agamma

30. anti - Jo 1
Poly/dermato myositis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Bruton's agamma
IL-12 def

31. Which MHC complex to CD4 cells bind
Common variable immunodeficiency (CVID)
Primary biliary cirrohosis
MHC II 4 x 2=8
Mixed connective tissue disease

32. Which antibodies activate the classic pathway
IgG - IgM GM makes classic cars
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
No - peptides only can can be presented on MHC molecules
Primary biliary cirrohosis

33. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
CD21
Chronic granulomatous disease
IgA
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

34. Which receptor on MACS to endotoxin directy stimulate?
CD14
Right arm and right half of head
Hyperacute : occlusion - ischemia - necrosis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

35. Which complement proteins make up the MAC
Scleroderma CREST
Wegeners granulomatosis
C5b -9
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

36. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Fc and Fab
Hashimotos
Sjorgen's syndrome

37. Defect in B cell maturation
2
IgG - IgM GM makes classic cars
Drug induced lupus
Common variable immunodeficiency (CVID)

38. How do CD8 cells kill?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Perforin - granzyme - granulysin
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IgM and IgD

39. Which is the most abundant immunoglobulin in the blood?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
II
IgG
Bruton's agamma

40. Which antibody mediates type II and type III hypersens rxn
Stomach
Sjorgen's syndrome
IgG
Selective Ig def - IgA most common

41. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
RA - DM type 1
Hyperacute : occlusion - ischemia - necrosis
Hemochromocytosis
DiGeorge

42. How are NK cells stimulated?
Paracortex
B cell localization and proliferation
IL-12 - IFN- beta. IFN- alpha
Regulates the humoral response

43. T cell dysfunction
SLE
IgM and IgD
Chronic mucocutaneaous candidiasis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

44. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Paracortex
Ataxia telangectasia

45. What is the difference in antigenic variation in viruses
Major shift minor drift
Corticomedullary junction
IL-12 - IFN- beta. IFN- alpha
Mesenchyme

46. What kind of hypersens rxn in anaphylaxis
Poly/dermato myositis
IL-12 def
I
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

47. How do NK cells kill?
Adaptive
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Perforin - granzyme - granulysin

48. Which is the receptors for EBV?
III
CD21
RA
IL-12

49. Defect in LFA-1 integrin CD18 protein on phagocytes
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Leukocyte adhesion deficiency type 1
Graves' dz
Hereditary angioedema

50. What is the arthus rxn?
Innate
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Fc