Test your basic knowledge |

Immunology

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which complement protein opsonizes bacteria?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
C3b
IL-12
Hyper IgE syndrome (Job's)

2. antismooth muscle
Common variable immunodeficiency (CVID)
Scleroderma CREST
Autoimmune hepatitis
IgE

3. Antihistone
Right arm and right half of head
CD40 and CD40L
Drug induced lupus
III

4. anti U1 RNP
Scleroderma diffuse
Fc
Mixed connective tissue disease
Stomach

5. What are the three things you find post splenectomy
B cell localization and proliferation
Autoimmune hepatitis
Drug induced lupus
Howell - Jolly bodies - Target cells - thrombocytosis

6. Which area of the lymph node englarges in an extreme immune response
Opsonization - neutralization and complement activation
Stomach
Paracortex
RA - DM type 1

7. Which type of hypersens rxn is the arthus rxn
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
III
Pemphigus vulgaris
IgG

8. Th cells don't produce IFN gamma - no PMN response

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

9. Where is MHC II expressed and and which HLA molecules codes for it
Superficial inguinal pectinate line
APCs - and DR - DP and DQ
Adaptive
Ataxia telangectasia

10. What does the thoracic duct drain?
Wegeners granulomatosis
SCID
Everything else - not right arm and right half of head
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

11. anti SS A/B or anti Ro/La

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

12. What embryologic tissue are lymphcytes derived from
Mesenchyme
Goodpastures
Sjorgen's syndrome
APCs - and DR - DP and DQ

13. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
RA
IgA
Hyperacute : occlusion - ischemia - necrosis
Mesenchyme

14. ANA
SLE - nonspecific
Hyper IgE syndrome (Job's)
I
Regulates the humoral response

15. What interferes with viruses?
Trypanosomes - programmed rearrangement
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Hashimotos
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

16. Which cytokine induces Th2 cell profile in CD4 cells
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IV
Il -4
Hyper IgE syndrome (Job's)

17. Which type of hypersens rxn is delayed
IV
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-12 def
Sjorgen's syndrome

18. How do NK cells kill?
Other vasculitidies
IL-12
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

19. Which antibody mediates type II and type III hypersens rxn
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Everything else - not right arm and right half of head
IgG
Regulates the humoral response

20. Which kind of immunity is germline encoded?
IL-12
Innate
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

21. What are the two signals in cytotoxic T cells activation?
Macs - dendritic cell - B cell
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Goodpastures

22. Defect in CD40L on helper T
Hyper IgM
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Il -4

23. antidesmoglein
Perforin - granzyme - granulysin
IgM and IgD
Hemochromocytosis
Pemphigus vulgaris

24. What is the arthus rxn?
Il -4
RA - DM type 1
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
MHC I

25. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Drug induced lupus
SCID
IgG

26. What is the difference in antigenic variation in viruses
IgM and IgD
Major shift minor drift
Perforin - granzyme - granulysin
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

27. Which parts of the antibody to light chain contribute
Hashimotos
Fab
Drug induced lupus
Hemochromocytosis

28. Defect in DNA repair enzymes
Ataxia telangectasia
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Mature t cells - epithelial reticular cells - Hassalls corpuscles
III

29. What is the main function of IgA
Paracortex
Scleroderma CREST
Prevents attachment of bacteria and viruses to mucous membranes
IL-12 def

30. What do you find in the medulla of the thymus?
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Secondary
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Hereditary angioedema

31. Which type of hypersens rxn is serum sickness?
Superficial inguinal pectinate line
IgM
IgG
III

32. HLA- B27

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

33. What are the two signals required for B cells class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IL-12 def
III
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

34. transplant rejection: T cell and antibody mediated vasular damage
Chediak Higashi
Chronic: fibrosis of graft tissue and blood vessels
Il -4
Secondary

35. Defectin in isotype switching
Bruton's agamma
Chediak Higashi
Selective Ig def - IgA most common
I

36. antigliadin - antiendomysial
Ceilac disase
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

37. Which is the receptors for EBV?
III
Hereditary angioedema
CD21
APCs - and DR - DP and DQ

38. Which infections require administering passive immunity?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Mesenchyme
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IL-12

39. HLA- A3
Perforin - granzyme - granulysin
Hemochromocytosis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Everything else - not right arm and right half of head

40. which follicles (primary or secondary) have active germinal centers?
Secondary
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Drug induced lupus
IgM and IgD

41. T cell dysfunction
CD56
Chronic mucocutaneaous candidiasis
Regulates the humoral response
Adaptive

42. Deficiency in DAF
Hyper IgM
Pemphigus vulgaris
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
PMNs recruited by IL-8 to clear infxns

43. Which complement proteins make up the MAC
Stomach
CD56
Hashimotos
C5b -9

44. Which receptor on MACS to endotoxin directy stimulate?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
CD14
Superficial inguinal pectinate line

45. What is the role of CD4 cels
S. aureus and S. pyogenes
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgA
Help B cells make antibody - secrete IFN gamma to activate macs

46. antimicrosomal - antithyroglobulin
Hashimotos
Paracortex
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
No - peptides only can can be presented on MHC molecules

47. What kind of bacteria do macrophages remove from the spleen?
Wegeners granulomatosis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
MS - hay fever - SLE - goodpasture's
Pemphigus vulgaris

48. HLA- DR5
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

49. Transplant rejection: preformed host antibody mediated
Goodpastures
Hyperacute : occlusion - ischemia - necrosis
Chronic granulomatous disease
Mature t cells - epithelial reticular cells - Hassalls corpuscles

50. Which MHC complex to CD8 cells bind
MHC I
Scleroderma diffuse
IgM
Paracortex