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Immunology

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Answer 50 questions in 15 minutes.
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1. What does a deficiency in C3 lead to...
Prevents attachment of bacteria and viruses to mucous membranes
SCID
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
II

2. How many signals are required for T cell activation or B cell class switching?
2
Ceilac disase
Innate
III

3. HLA- DR5
B cell localization and proliferation
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Poly/dermato myositis
CD56

4. Deficiency in DAF
MS - hay fever - SLE - goodpasture's
III
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Macs - dendritic cell - B cell

5. anti - Jo 1
IgG - IgM GM makes classic cars
Opsonization - neutralization and complement activation
Poly/dermato myositis
Hereditary angioedema

6. Which type of hypersens rxn is antibody mediated?
IL-2 and IFN gamma
MS - hay fever - SLE - goodpasture's
II
Common variable immunodeficiency (CVID)

7. Which B T cell interaction allows for immunologic memory and class switching?
Wegeners granulomatosis
Scleroderma diffuse
Ataxia telangectasia
CD40 and CD40L

8. What happens in the follicle of the lymph node
Hyperacute : occlusion - ischemia - necrosis
CD8 cells
B cell localization and proliferation
MHC II 4 x 2=8

9. How are NK cells stimulated?
Bruton's agamma
Autoimmune hepatitis
Regulates the humoral response
IL-12 - IFN- beta. IFN- alpha

10. What are the two signals required for B cells class switching?
Regulates the humoral response
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
CD56
Wegeners granulomatosis

11. Which cell mediates the type IV hypersens rxn?
CD8 cells
MHC I
MHC II 4 x 2=8
All nucleated cells (no RBCs) A - B - C

12. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Bruton's agamma
Chronic granulomatous disease
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Upper limb and breast

13. What cytokines to Th2 cells secrete?
DiGeorge
All nucleated cells (no RBCs) A - B - C
MHC I
IL-4 - 5 - 10

14. Which portion of the antibody determines the isotype
Hashimotos
IV
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Fc

15. Which bacteria secrete superantigen
Signal 1 = APC - signal 2 = B7 and CD28
Hereditary angioedema
Fc
S. aureus and S. pyogenes

16. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
RA - DM type 1
I

17. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
IgG
IgA
Fc

18. What do you find in the medulla of the thymus?
Graves' dz
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Leukocyte adhesion deficiency type 1
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

19. What does the thoracic duct drain?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
No - peptides only can can be presented on MHC molecules
Everything else - not right arm and right half of head
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

20. What are the 4 T's of type IV hypersense
IgA
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-4 - 5 - 10
CD8 cells

21. Which kind of immunity is germline encoded?
Howell - Jolly bodies - Target cells - thrombocytosis
IL-12
Innate
Bruton's agamma

22. What does the Th2 response do?
Paracortex
Steroid - responsive nephrotic syndrome
Regulates the humoral response
Signal 1 = APC - signal 2 = B7 and CD28

23. Defect in CD40L on helper T
APCs - and DR - DP and DQ
Hyper IgM
Hyper IgE syndrome (Job's)
CD14

24. Which is the receptors for EBV?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
CD21
I
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

25. Cell surface receptors on T cells
Everything else - not right arm and right half of head
Bruton's agamma
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Scleroderma CREST

26. which kind of immunity is characterized by receptors that undergo VDJ recombination?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Hereditary angioedema
Adaptive

27. antimicrosomal - antithyroglobulin
SLE
Hashimotos
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Chronic granulomatous disease

28. What are the classic example of bacterial antigen variation and the unique mechanims
IFN gamma
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MHC I

29. anti SS A/B or anti Ro/La

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30. anti glutamate decarboxylase
DM type 1
IL-12
Everything else - not right arm and right half of head
Chediak Higashi

31. Which lymph node drains the anal canal below
III
IgM and IgD
Superficial inguinal pectinate line
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

32. Which antibody mediates type II and type III hypersens rxn
SCID
II
Prevents attachment of bacteria and viruses to mucous membranes
IgG

33. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
SLE
Right arm and right half of head
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

34. Defectin in isotype switching
Selective Ig def - IgA most common
Howell - Jolly bodies - Target cells - thrombocytosis
IgA
Regulates the humoral response

35. anti basement membrane
Ceilac disase
Goodpastures
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
MHC II 4 x 2=8

36. Anti - IgG (RF)
RA
IgG
IgG - IgM GM makes classic cars
SLE

37. T cell dysfunction
Fab
Chronic mucocutaneaous candidiasis
Hyper IgE syndrome (Job's)
Major shift minor drift

38. What are the three things you find post splenectomy
Graves' dz
Howell - Jolly bodies - Target cells - thrombocytosis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Regulates the humoral response

39. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
DiGeorge
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

40. What does a deficiency in C5- C8 lead to?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
III
APCs - and DR - DP and DQ
Neisseria bacteremia

41. What are the three APCs
IL-12 - IFN- beta. IFN- alpha
Macs - dendritic cell - B cell
C3b
Hyper IgE syndrome (Job's)

42. What does clean up on Aisle 8 stand for?
No - peptides only can can be presented on MHC molecules
PMNs recruited by IL-8 to clear infxns
Chronic mucocutaneaous candidiasis
B cell localization and proliferation

43. antigliadin - antiendomysial
Ceilac disase
Corticomedullary junction
Neisseria bacteremia
IL-2 and IFN gamma

44. What is the main function of IgA
Chronic mucocutaneaous candidiasis
Prevents attachment of bacteria and viruses to mucous membranes
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

45. Which is the most abundant immunoglobulin in the blood?
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IgG
I
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

46. Which antibody (IgM or IgG) crosses the placenta?
CD56
Hyper IgE syndrome (Job's)
IgG
DiGeorge

47. antidesmoglein
Pemphigus vulgaris
Ataxia telangectasia
MS - hay fever - SLE - goodpasture's
IgE

48. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Wegeners granulomatosis
C3b
Scleroderma diffuse
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

49. decreased Th1 response
Chronic mucocutaneaous candidiasis
IL-12 def
Scleroderma CREST
Superficial inguinal pectinate line

50. What is the role of CD4 cels
Chronic: fibrosis of graft tissue and blood vessels
MS - hay fever - SLE - goodpasture's
Help B cells make antibody - secrete IFN gamma to activate macs
CD56

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