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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What is the difference in antigenic variation in viruses
Selective Ig def - IgA most common
Everything else - not right arm and right half of head
Fc and Fab
Major shift minor drift

2. transplant rejection: T cell and antibody mediated vasular damage
Other vasculitidies
IgM
Chronic: fibrosis of graft tissue and blood vessels
Graves' dz

3. Which MHC complex to CD8 cells bind
Hyper IgE syndrome (Job's)
CD56
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
MHC I

4. Which type of hypersens rxn is the arthus rxn
Fc
C3b
RA - DM type 1
III

5. AR - defect in microtubule fxn with decreased phagocytosis
IL-12 - IFN- beta. IFN- alpha
Chediak Higashi
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

6. Which parts of the antibody to heavy chain contribute?
MHC I
Fc and Fab
RA - DM type 1
2

7. What are the classic example of bacterial antigen variation and the unique mechanims
Major shift minor drift
Selective Ig def - IgA most common
Opsonization - neutralization and complement activation
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

8. anti U1 RNP
Mixed connective tissue disease
SLE
CD21
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

9. HLA- D2

10. Which areas of the body are drained by the axillary lymph node
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Goodpastures
Upper limb and breast
Innate

11. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
RA - DM type 1
SCID
Goodpastures

12. Which antibodies activate the classic pathway
Hereditary angioedema
IgG - IgM GM makes classic cars
SCID
Chronic mucocutaneaous candidiasis

13. thwat does the Right lymphatic duct drain?
Opsonization - neutralization and complement activation
Drug induced lupus
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Right arm and right half of head

14. Which antibody (IgM or IgG) crosses the placenta?
Hashimotos
B cell localization and proliferation
IgG
Paracortex

15. What does a deficiency in C5- C8 lead to?
II
Neisseria bacteremia
SLE
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

16. which kind of immunity is characterized by receptors that undergo VDJ recombination?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Adaptive
Hereditary angioedema
IL-12 - IFN- beta. IFN- alpha

17. What are the two signals required for B cells class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
IL-12 - IFN- beta. IFN- alpha
2
RA

18. antigliadin - antiendomysial
Ceilac disase
RA - DM type 1
Hereditary angioedema
IgG

19. What are the three things you find post splenectomy
Help B cells make antibody - secrete IFN gamma to activate macs
Howell - Jolly bodies - Target cells - thrombocytosis
MS - hay fever - SLE - goodpasture's
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

20. antismooth muscle
MHC II 4 x 2=8
CD40 and CD40L
Autoimmune hepatitis
Chronic: fibrosis of graft tissue and blood vessels

21. Antihistone
Secondary
Right arm and right half of head
Drug induced lupus
Hereditary angioedema

22. Where do positive and negative selection occur in the thymus?
Chronic granulomatous disease
Corticomedullary junction
II
C5b -9

23. What interferes with viruses?
Chediak Higashi
Everything else - not right arm and right half of head
IgG - IgM GM makes classic cars
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

24. How do NK cells kill?
DiGeorge
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Goodpastures

25. Which immunoglobulin is a pentamer
Chronic mucocutaneaous candidiasis
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Ceilac disase
IgM

26. HLA- A3
Hemochromocytosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
No - peptides only can can be presented on MHC molecules

27. anti - Jo 1
DM type 1
Poly/dermato myositis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-12 - IFN- beta. IFN- alpha

28. anti basement membrane
CD21
Hereditary angioedema
Signal 1 = APC - signal 2 = B7 and CD28
Goodpastures

29. decreased Th1 response
II
IL-12 def
IV
III

30. HLA- B8

31. Which type of hypersens rxn is immune complex mediate
III
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Hemochromocytosis
IgA

32. X- linked recessive defect with progessive deletion of B and T cells
CD14
Hyper IgE syndrome (Job's)
DM type 1
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

33. Anti - IgG (RF)
RA
Common variable immunodeficiency (CVID)
CD14
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

34. What kind of bacteria do macrophages remove from the spleen?
Chronic mucocutaneaous candidiasis
III
Right arm and right half of head
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

35. How many signals are required for T cell activation or B cell class switching?
2
IL-4 - 5 - 10
Mixed connective tissue disease
APCs - and DR - DP and DQ

36. Which cytokine induces Th1 cell profile in CD4 cells
MS - hay fever - SLE - goodpasture's
Opsonization - neutralization and complement activation
Chronic mucocutaneaous candidiasis
IL-12

37. Deficiency in DAF
Prevents attachment of bacteria and viruses to mucous membranes
Macs - dendritic cell - B cell
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
CD21

38. Which is the most abundant immunoglobulin in the blood?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IgG
Common variable immunodeficiency (CVID)
Fab

39. Which area of the lymph node englarges in an extreme immune response
IgA
Ataxia telangectasia
Leukocyte adhesion deficiency type 1
Paracortex

40. Anti Scl 70 (DNA topo I
Corticomedullary junction
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgG - IgM GM makes classic cars
Scleroderma diffuse

41. Which parts of the antibody to light chain contribute
Mixed connective tissue disease
Fab
Secondary
Paracortex

42. Defect in B cell maturation
Common variable immunodeficiency (CVID)
Scleroderma CREST
Primary biliary cirrohosis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

43. Which complement proteins make up the MAC
Poly/dermato myositis
IgG - IgM GM makes classic cars
C5b -9
Chronic granulomatous disease

44. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
CD21
Chronic granulomatous disease
Steroid - responsive nephrotic syndrome
IL-12 - IFN- beta. IFN- alpha

45. Which type of hypersens rxn is antibody mediated?
Hyper IgE syndrome (Job's)
II
Poly/dermato myositis
DM type 1

46. HLA- DR5
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Graves' dz
Scleroderma diffuse

47. Which antibody mediates a type Hypersens rxn?
CD14
IL-4 - 5 - 10
IgE
Wegeners granulomatosis

48. What do you find in the medulla of the thymus?
Il -4
Bruton's agamma
Fc and Fab
Mature t cells - epithelial reticular cells - Hassalls corpuscles

49. Which receptor on MACS to endotoxin directy stimulate?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Mesenchyme
IgM and IgD
CD14

50. Cell surface receptors on T cells
Autoimmune hepatitis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
IL-10