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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. antimicrosomal - antithyroglobulin
Hashimotos
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Mixed connective tissue disease

2. HLA- DR5
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Neisseria bacteremia
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Pemphigus vulgaris

3. Defectin in isotype switching
Scleroderma CREST
Selective Ig def - IgA most common
APCs - and DR - DP and DQ
IFN gamma

4. Anticentromere
Il -4
Scleroderma CREST
Ataxia telangectasia
Poly/dermato myositis

5. What is the main function of IgA
Major shift minor drift
Right arm and right half of head
Prevents attachment of bacteria and viruses to mucous membranes
IV

6. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
No - peptides only can can be presented on MHC molecules
APCs - and DR - DP and DQ
IL-12 def
IgA

7. Anti ds DNA - anti Smith
Pemphigus vulgaris
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
SLE

8. Which cytokine induces Th2 cell profile in CD4 cells
Il -4
Hereditary angioedema
CD40 and CD40L
CD21

9. What kind of bacteria do macrophages remove from the spleen?
DM type 1
Mature t cells - epithelial reticular cells - Hassalls corpuscles
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

10. What interferes with viruses?
Common variable immunodeficiency (CVID)
B cell localization and proliferation
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Everything else - not right arm and right half of head

11. Anti - IgG (RF)
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hyper IgM
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
RA

12. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
APCs - and DR - DP and DQ
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IgM and IgD
Signal 1 = APC - signal 2 = B7 and CD28

13. What do superantigens do?
IgG
Other vasculitidies
DiGeorge
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

14. How are NK cells stimulated?
APCs - and DR - DP and DQ
All nucleated cells (no RBCs) A - B - C
IL-12 - IFN- beta. IFN- alpha
Steroid - responsive nephrotic syndrome

15. What embryologic tissue are lymphcytes derived from
Hemochromocytosis
Mesenchyme
Paracortex
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

16. Which receptor on MACS to endotoxin directy stimulate?
Ataxia telangectasia
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Stomach
CD14

17. Which antibody mediates type II and type III hypersens rxn
Il -4
IgG
CD14
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

18. Which kind of immunity is germline encoded?
IL-12
Innate
Prevents attachment of bacteria and viruses to mucous membranes
Everything else - not right arm and right half of head

19. What is the arthus rxn?
Il -4
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Wegeners granulomatosis
Innate

20. Which parts of the antibody to heavy chain contribute?
IgG - IgM GM makes classic cars
IL-10
Fc and Fab
IgG

21. Which cell mediates the type IV hypersens rxn?
Sjorgen's syndrome
CD8 cells
Other vasculitidies
Paracortex

22. How do CD8 cells kill?
Stomach
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Perforin - granzyme - granulysin
Ataxia telangectasia

23. Defect in B cell maturation
All nucleated cells (no RBCs) A - B - C
Common variable immunodeficiency (CVID)
RA - DM type 1
Paracortex

24. What is the difference in antigenic variation in viruses
Major shift minor drift
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Neisseria bacteremia
S. aureus and S. pyogenes

25. Which type of hypersens rxn is delayed
IL-10
Hereditary angioedema
IV
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

26. What does the thoracic duct drain?
Secondary
Everything else - not right arm and right half of head
Goodpastures
DM type 1

27. anti - Jo 1
Fc and Fab
Prevents attachment of bacteria and viruses to mucous membranes
Poly/dermato myositis
Ceilac disase

28. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Regulates the humoral response
Mixed connective tissue disease

29. What does a deficiency in C1 esterase inhibitor lead to?
Sjorgen's syndrome
Prevents attachment of bacteria and viruses to mucous membranes
RA
Hereditary angioedema

30. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
SCID
Fc
C3b
IL-4 - 5 - 10

31. Which type of hypersens rxn is serum sickness?
C3b
III
Graves' dz
Fab

32. What happens in the follicle of the lymph node
IgG
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
B cell localization and proliferation
S. aureus and S. pyogenes

33. decreased Th1 response
IL-12 def
IgG
Adaptive
Leukocyte adhesion deficiency type 1

34. Which type of hypersens rxn is immune complex mediate
Regulates the humoral response
RA - DM type 1
Graves' dz
III

35. thwat does the Right lymphatic duct drain?
Chronic: fibrosis of graft tissue and blood vessels
Macs - dendritic cell - B cell
Right arm and right half of head
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

36. What do mature B lymphos express on their surface?
RA
Secondary
IgM and IgD
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

37. anti glutamate decarboxylase
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
DM type 1
Hemochromocytosis
Everything else - not right arm and right half of head

38. What cytokines to Th2 cells secrete?
Prevents attachment of bacteria and viruses to mucous membranes
DM type 1
IL-4 - 5 - 10
Chediak Higashi

39. antismooth muscle
DiGeorge
Trypanosomes - programmed rearrangement
Autoimmune hepatitis
Corticomedullary junction

40. anti basement membrane
Goodpastures
B cell localization and proliferation
Wegeners granulomatosis
Major shift minor drift

41. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Il -4
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

42. What are the two signals required for B cells class switching?
IL-12 - IFN- beta. IFN- alpha
Bruton's agamma
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

43. Which parts of the antibody to light chain contribute
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Hyper IgE syndrome (Job's)
Fab
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

44. HLA- B27

45. Which MHC complex to CD8 cells bind
MHC I
Prevents attachment of bacteria and viruses to mucous membranes
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Chronic: fibrosis of graft tissue and blood vessels

46. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Adaptive
Macs - dendritic cell - B cell

47. What does a deficiency in C5- C8 lead to?
RA
Hyper IgE syndrome (Job's)
Neisseria bacteremia
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

48. What are the classic example of bacterial antigen variation and the unique mechanims
MHC I
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
I
Drug induced lupus

49. X linked recessive defect in BTK no B cell differentiation

50. AR - defect in microtubule fxn with decreased phagocytosis
Graves' dz
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Chediak Higashi
Primary biliary cirrohosis