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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. X- linked recessive defect with progessive deletion of B and T cells
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Fc
2
Hereditary angioedema

2. Which antibodies activate the classic pathway
RA - DM type 1
IL-12
IgG - IgM GM makes classic cars
RA

3. antidesmoglein
CD21
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Pemphigus vulgaris
Fab

4. How do NK cells kill?
DM type 1
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IgG
Fc and Fab

5. Th cells don't produce IFN gamma - no PMN response

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6. transplant rejection: T cell and antibody mediated vasular damage
Paracortex
Ceilac disase
C5b -9
Chronic: fibrosis of graft tissue and blood vessels

7. Which cytokine induces Th1 cell profile in CD4 cells
IV
IL-12
Steroid - responsive nephrotic syndrome
IL-2 and IFN gamma

8. which areas of the body are drained by the celiac lymph node?
II
Secondary
Stomach
Mixed connective tissue disease

9. HLA- A3
CD40 and CD40L
Hemochromocytosis
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgA

10. What happens in the follicle of the lymph node
Hereditary angioedema
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
B cell localization and proliferation
III

11. Transplant rejection: preformed host antibody mediated
I
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Hyperacute : occlusion - ischemia - necrosis
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

12. Which kind of immunity is germline encoded?
III
Ataxia telangectasia
Innate
Stomach

13. Which MHC complex to CD8 cells bind
RA
MHC I
MHC II 4 x 2=8
Stomach

14. ANA
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Primary biliary cirrohosis
SLE - nonspecific
III

15. Which areas of the body are drained by the axillary lymph node
Common variable immunodeficiency (CVID)
Hashimotos
B cell localization and proliferation
Upper limb and breast

16. Which type of hypersens rxn is the arthus rxn
SLE
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Neisseria bacteremia
III

17. Defect in DNA repair enzymes
CD14
Ataxia telangectasia
CD8 cells
Goodpastures

18. What are the cell surface receptors on MACS
MS - hay fever - SLE - goodpasture's
Hemochromocytosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Paracortex

19. Cell surface receptors on T cells
Adaptive
IL-4 - 5 - 10
Corticomedullary junction
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

20. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Hyper IgM
Regulates the humoral response
B cell localization and proliferation

21. How are NK cells stimulated?
Chronic mucocutaneaous candidiasis
Hyper IgE syndrome (Job's)
IL-12 - IFN- beta. IFN- alpha
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

22. AR - defect in microtubule fxn with decreased phagocytosis
Chediak Higashi
IL-10
SLE
Hyper IgM

23. Which type of hypersens rxn is immune complex mediate
Paracortex
III
Goodpastures
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

24. What are the three things you find post splenectomy
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IL-12 def
Howell - Jolly bodies - Target cells - thrombocytosis
IgM

25. What are the 3 funxtions of antibodies?
Major shift minor drift
Opsonization - neutralization and complement activation
Regulates the humoral response
IgA

26. What are the two signals in helper T activation?
IL-2 and IFN gamma
Signal 1 = APC - signal 2 = B7 and CD28
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
B cell localization and proliferation

27. thwat does the Right lymphatic duct drain?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Regulates the humoral response
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Right arm and right half of head

28. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
IV
IL-10
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Il -4

29. What interferes with viruses?
Macs - dendritic cell - B cell
Adaptive
IL-12 def
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

30. What kind of hypersens rxn in anaphylaxis
I
RA - DM type 1
Right arm and right half of head
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

31. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
IgA
DM type 1
IgG - IgM GM makes classic cars
C5b -9

32. Which antibody mediates type II and type III hypersens rxn
Chronic: fibrosis of graft tissue and blood vessels
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgG
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

33. Where is MHC I expressed - and which HLA molecules code for it
IL-12
Signal 1 = APC - signal 2 = B7 and CD28
All nucleated cells (no RBCs) A - B - C
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

34. What does a deficiency in C3 lead to...
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
I
Mixed connective tissue disease
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

35. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
Other vasculitidies
SCID
Drug induced lupus
Graves' dz

36. Which antibody (IgM or IgG) crosses the placenta?
Steroid - responsive nephrotic syndrome
Chronic granulomatous disease
Primary biliary cirrohosis
IgG

37. What are the 4 T's of type IV hypersense
Hyper IgM
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

38. Antimitochondrial
IL-10
Primary biliary cirrohosis
PMNs recruited by IL-8 to clear infxns
Selective Ig def - IgA most common

39. What does a deficiency in C5- C8 lead to?
CD56
Perforin - granzyme - granulysin
Neisseria bacteremia
IL-4 - 5 - 10

40. What do mature B lymphos express on their surface?
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IgM and IgD
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Signal 1 = APC - signal 2 = B7 and CD28

41. Which complement protein opsonizes bacteria?
Superficial inguinal pectinate line
Hashimotos
C3b
IgG

42. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
III
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

43. Which complement proteins make up the MAC
IL-4 - 5 - 10
Ataxia telangectasia
C5b -9
Leukocyte adhesion deficiency type 1

44. HLA- DR4
Ataxia telangectasia
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
RA - DM type 1
Paracortex

45. HLA- B8

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46. which kind of immunity is characterized by receptors that undergo VDJ recombination?
No - peptides only can can be presented on MHC molecules
Adaptive
Goodpastures
SLE - nonspecific

47. What does HOT- T- Bone stEAk stand for?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Hashimotos
Mesenchyme
III

48. What is the difference in antigenic variation in viruses
Innate
Mixed connective tissue disease
Major shift minor drift
C3b

49. What are the three APCs
Macs - dendritic cell - B cell
RA - DM type 1
Scleroderma diffuse
Howell - Jolly bodies - Target cells - thrombocytosis

50. Which is the receptors for EBV?
Ataxia telangectasia
Hyper IgE syndrome (Job's)
CD21
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly