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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What is the unique cell marker for NK cells
CD56
B cell localization and proliferation
Signal 1 = APC - signal 2 = B7 and CD28
Other vasculitidies

2. Which kind of immunity is germline encoded?
Innate
III
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IgG

3. antismooth muscle
Hyperacute : occlusion - ischemia - necrosis
Regulates the humoral response
Autoimmune hepatitis
B cell localization and proliferation

4. Which cytokine induces Th1 cell profile in CD4 cells
Hyperacute : occlusion - ischemia - necrosis
IL-12
Bruton's agamma
Chediak Higashi

5. Which cell mediates the type IV hypersens rxn?
C3b
IgA
Chronic granulomatous disease
CD8 cells

6. decreased Th1 response
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Chronic mucocutaneaous candidiasis
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IL-12 def

7. How many signals are required for T cell activation or B cell class switching?
Right arm and right half of head
Neisseria bacteremia
MHC II 4 x 2=8
2

8. Which antibody mediates a type Hypersens rxn?
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IgE
CD21
Poly/dermato myositis

9. Which complement proteins make up the MAC
Ataxia telangectasia
2
II
C5b -9

10. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
DiGeorge
Steroid - responsive nephrotic syndrome
IL-2 and IFN gamma

11. X linked IL-2 receptor defect - adenosine deaminase deficiency - failure to synthesize MHC II
IgG
Hyper IgM
SCID
Graves' dz

12. Anti ds DNA - anti Smith
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
SLE
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

13. HLA- DR3
Hereditary angioedema
Ataxia telangectasia
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
DM type 1

14. Cell surface receptors on B cels
SLE - nonspecific
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Innate
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

15. What are the cell surface receptors on MACS
Drug induced lupus
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

16. Which antibodies activate the classic pathway
IL-10
CD8 cells
IgG - IgM GM makes classic cars
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

17. Which type of hypersens rxn is delayed
IV
RA - DM type 1
II
Innate

18. What are the 3 funxtions of antibodies?
Opsonization - neutralization and complement activation
MS - hay fever - SLE - goodpasture's
Signal 1 = APC - signal 2 = B7 and CD28
Primary biliary cirrohosis

19. antidesmoglein
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
I
CD8 cells
Pemphigus vulgaris

20. What are the cytokines involved in macrophage/lymphocyte interaction
Howell - Jolly bodies - Target cells - thrombocytosis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
RA

21. HLA- B27

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22. Defect in B cell maturation
Common variable immunodeficiency (CVID)
IgG
IL-12
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

23. Which cytokine induces Th2 cell profile in CD4 cells
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-12 - IFN- beta. IFN- alpha
Il -4
Hyperacute : occlusion - ischemia - necrosis

24. Which cytokines to Th1 cells secrete?
IL-2 and IFN gamma
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Chronic granulomatous disease
IL-12 - IFN- beta. IFN- alpha

25. What are the two signals in cytotoxic T cells activation?
IL-12 def
Adaptive
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Secondary

26. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
Hemochromocytosis
Stomach
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Chronic granulomatous disease

27. Which area of the lymph node englarges in an extreme immune response
SCID
Paracortex
Pemphigus vulgaris
Ceilac disase

28. c - ANCA
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Wegeners granulomatosis
APCs - and DR - DP and DQ

29. anti SS A/B or anti Ro/La

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30. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
Right arm and right half of head
IL-12 - IFN- beta. IFN- alpha
2
IgA

31. What are the classic example of bacterial antigen variation and the unique mechanims
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IgM
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgG

32. which follicles (primary or secondary) have active germinal centers?
Paracortex
IL-10
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Secondary

33. What do you find in the medulla of the thymus?
Trypanosomes - programmed rearrangement
Howell - Jolly bodies - Target cells - thrombocytosis
2
Mature t cells - epithelial reticular cells - Hassalls corpuscles

34. What are the 4 T's of type IV hypersense
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
IL-4 - 5 - 10
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
II

35. HLA- DR7
Sjorgen's syndrome
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Steroid - responsive nephrotic syndrome
IgG

36. Anti - IgG (RF)
RA
Perforin - granzyme - granulysin
Chronic: fibrosis of graft tissue and blood vessels
Scleroderma diffuse

37. Which cytokine inhibits Th1 cells
Mesenchyme
IL-10
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
IL-2 and IFN gamma

38. Which complement protein opsonizes bacteria?
Howell - Jolly bodies - Target cells - thrombocytosis
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Hyperacute : occlusion - ischemia - necrosis
C3b

39. Antihistone
MHC I
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Drug induced lupus
SCID

40. What embryologic tissue are lymphcytes derived from
Mesenchyme
IL-12 - IFN- beta. IFN- alpha
S. aureus and S. pyogenes
Pernicious anemia (to B12 def) - hashimotos thyroiditis

41. Which type of hypersens rxn is the arthus rxn
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Mature t cells - epithelial reticular cells - Hassalls corpuscles
III
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

42. What is the clinical picture for serum sickness?
Everything else - not right arm and right half of head
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Upper limb and breast
Signal 1 = APC - signal 2 = B7 and CD28

43. which areas of the body are drained by the celiac lymph node?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
No - peptides only can can be presented on MHC molecules
Stomach
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

44. How do NK cells kill?
Il -4
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Signal 1 = APC - signal 2 = B7 and CD28

45. What does HOT- T- Bone stEAk stand for?
Upper limb and breast
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Hyper IgM

46. Which type of hypersens rxn is immune complex mediate
B cell localization and proliferation
Ceilac disase
III
I

47. Where do positive and negative selection occur in the thymus?
III
Everything else - not right arm and right half of head
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Corticomedullary junction

48. What does clean up on Aisle 8 stand for?
IV
Adaptive
IgG - IgM GM makes classic cars
PMNs recruited by IL-8 to clear infxns

49. AR - defect in microtubule fxn with decreased phagocytosis
Prevents attachment of bacteria and viruses to mucous membranes
MHC II 4 x 2=8
Chediak Higashi
IgM

50. ANA
SLE - nonspecific
Sjorgen's syndrome
Poly/dermato myositis
Graves' dz