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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. which follicles (primary or secondary) have active germinal centers?
Secondary
Prevents attachment of bacteria and viruses to mucous membranes
CD14
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

2. Which parts of the antibody to heavy chain contribute?
Hyperacute : occlusion - ischemia - necrosis
Poly/dermato myositis
Hyper IgE syndrome (Job's)
Fc and Fab

3. Which cytokine induces Th1 cell profile in CD4 cells
Trypanosomes - programmed rearrangement
IgG
IL-10
IL-12

4. HLA- DR4
Ceilac disase
IL-12
RA - DM type 1
RA

5. HLA- DR7
CD14
Scleroderma CREST
Adaptive
Steroid - responsive nephrotic syndrome

6. Which type of hypersens rxn is delayed
IV
IL-4 - 5 - 10
CD40 and CD40L
IL-2 and IFN gamma

7. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Macs - dendritic cell - B cell
Regulates the humoral response

8. Which infections require administering passive immunity?
Signal 1 = APC - signal 2 = B7 and CD28
Hashimotos
Major shift minor drift
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

9. Which type of hypersens rxn is antibody mediated?
Pernicious anemia (to B12 def) - hashimotos thyroiditis
B cell localization and proliferation
II
2

10. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
DM type 1
IL-12
I
DiGeorge

11. Which is the receptors for EBV?
IL-12 - IFN- beta. IFN- alpha
III
CD21
Major shift minor drift

12. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Mixed connective tissue disease
Neisseria bacteremia

13. Which antibodies activate the classic pathway
CD40 and CD40L
Corticomedullary junction
IgG - IgM GM makes classic cars
B cell localization and proliferation

14. Defect in CD40L on helper T
IL-10
Graves' dz
DM type 1
Hyper IgM

15. Deficiency in DAF
Hyperacute : occlusion - ischemia - necrosis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Neisseria bacteremia
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

16. What is the difference in antigenic variation in viruses
Major shift minor drift
Paracortex
III
IgM and IgD

17. Which MHC complex to CD8 cells bind
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
MHC I
Chronic mucocutaneaous candidiasis

18. Which MHC complex to CD4 cells bind
Ataxia telangectasia
SLE - nonspecific
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
MHC II 4 x 2=8

19. What are the three APCs
Macs - dendritic cell - B cell
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
B cell localization and proliferation
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

20. What does the Th2 response do?
Selective Ig def - IgA most common
Fc and Fab
MS - hay fever - SLE - goodpasture's
Regulates the humoral response

21. Which immunoglobulin is a pentamer
IgM
Scleroderma CREST
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

22. antimicrosomal - antithyroglobulin
Chronic mucocutaneaous candidiasis
MHC I
Hashimotos
Hyper IgE syndrome (Job's)

23. decreased Th1 response
IL-12 def
CD8 cells
Macs - dendritic cell - B cell
IL-12

24. HLA- DR5
Scleroderma CREST
Autoimmune hepatitis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
DM type 1

25. What do mature B lymphos express on their surface?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgM and IgD
Major shift minor drift
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

26. What are the two signals in cytotoxic T cells activation?
RA
RA - DM type 1
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Pemphigus vulgaris

27. What is the arthus rxn?
Macs - dendritic cell - B cell
DM type 1
Ataxia telangectasia
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

28. What kind of hypersens rxn in anaphylaxis
I
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
S. aureus and S. pyogenes

29. What cytokines to Th2 cells secrete?
Hyper IgE syndrome (Job's)
MS - hay fever - SLE - goodpasture's
CD21
IL-4 - 5 - 10

30. How do CD8 cells kill?
Scleroderma diffuse
Upper limb and breast
Perforin - granzyme - granulysin
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

31. c - ANCA
Perforin - granzyme - granulysin
Help B cells make antibody - secrete IFN gamma to activate macs
Stomach
Wegeners granulomatosis

32. What does the thoracic duct drain?
Everything else - not right arm and right half of head
CD40 and CD40L
Superficial inguinal pectinate line
DM type 1

33. antismooth muscle
Autoimmune hepatitis
SCID
Neisseria bacteremia
MHC II 4 x 2=8

34. Which parts of the antibody to light chain contribute
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
III
Fab
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)

35. What are the two signals required for B cells class switching?
Regulates the humoral response
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
CD56
Chronic granulomatous disease

36. HLA- DR3
IFN gamma
CD14
Hyper IgE syndrome (Job's)
DM type 1

37. X- linked recessive defect with progessive deletion of B and T cells
IL-12 - IFN- beta. IFN- alpha
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Pemphigus vulgaris
Macs - dendritic cell - B cell

38. Which type of hypersens rxn is serum sickness?
III
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
MHC II 4 x 2=8
No - peptides only can can be presented on MHC molecules

39. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Drug induced lupus
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

40. Anti - IgG (RF)
All nucleated cells (no RBCs) A - B - C
RA
IgM
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

41. Antihistone
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Help B cells make antibody - secrete IFN gamma to activate macs
No - peptides only can can be presented on MHC molecules
Drug induced lupus

42. Defect in DNA repair enzymes
Pemphigus vulgaris
IL-2 and IFN gamma
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Ataxia telangectasia

43. Defectin in isotype switching
2
IL-10
Selective Ig def - IgA most common
Regulates the humoral response

44. What happens in the follicle of the lymph node
B cell localization and proliferation
Chronic mucocutaneaous candidiasis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hyper IgE syndrome (Job's)

45. thwat does the Right lymphatic duct drain?
Howell - Jolly bodies - Target cells - thrombocytosis
Right arm and right half of head
Paracortex
IL-2 and IFN gamma

46. T cell dysfunction
RA - DM type 1
Wegeners granulomatosis
Chronic mucocutaneaous candidiasis
Hemochromocytosis

47. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD8 cells
Selective Ig def - IgA most common

48. Where is MHC I expressed - and which HLA molecules code for it
C5b -9
Adaptive
DM type 1
All nucleated cells (no RBCs) A - B - C

49. anti - Jo 1
IL-10
Poly/dermato myositis
Hyperacute : occlusion - ischemia - necrosis
Bruton's agamma

50. Where is MHC II expressed and and which HLA molecules codes for it
IgM and IgD
APCs - and DR - DP and DQ
Prevents attachment of bacteria and viruses to mucous membranes
Mature t cells - epithelial reticular cells - Hassalls corpuscles