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Immunology

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Answer 50 questions in 15 minutes.
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1. What are the three APCs
Macs - dendritic cell - B cell
Other vasculitidies
IL-2 and IFN gamma
Hereditary angioedema

2. antidesmoglein
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Chediak Higashi
Pemphigus vulgaris

3. AR - defect in microtubule fxn with decreased phagocytosis
Secondary
Fc
Wegeners granulomatosis
Chediak Higashi

4. Which cytokines to Th1 cells secrete?
Primary biliary cirrohosis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IL-2 and IFN gamma
Sjorgen's syndrome

5. Which portion of the antibody determines the isotype
Stomach
Fc
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgG

6. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
IgM and IgD
IgE
All nucleated cells (no RBCs) A - B - C
No - peptides only can can be presented on MHC molecules

7. Where is MHC I expressed - and which HLA molecules code for it
All nucleated cells (no RBCs) A - B - C
III
IL-12 def
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

8. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
MS - hay fever - SLE - goodpasture's
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Upper limb and breast
Wegeners granulomatosis

9. HLA- D2

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10. X- linked recessive defect with progessive deletion of B and T cells
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
APCs - and DR - DP and DQ
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Innate

11. What embryologic tissue are lymphcytes derived from
Right arm and right half of head
Mesenchyme
Corticomedullary junction
Hashimotos

12. Which lymph node drains the anal canal below
RA - DM type 1
Macs - dendritic cell - B cell
Chediak Higashi
Superficial inguinal pectinate line

13. p - ANCA
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Upper limb and breast
All nucleated cells (no RBCs) A - B - C
Other vasculitidies

14. Which complement proteins make up the MAC
IL-12 def
Innate
Major shift minor drift
C5b -9

15. What is the arthus rxn?
III
Neisseria bacteremia
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
DM type 1

16. Transplant rejection: preformed host antibody mediated
C3b
Hyperacute : occlusion - ischemia - necrosis
Adaptive
Regulates the humoral response

17. anti U1 RNP
DM type 1
Mixed connective tissue disease
2
Stomach

18. thwat does the Right lymphatic duct drain?
Graves' dz
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Right arm and right half of head
IgG

19. antimicrosomal - antithyroglobulin
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Prevents attachment of bacteria and viruses to mucous membranes
IgG - IgM GM makes classic cars
Hashimotos

20. HLA- DR3
Hyper IgE syndrome (Job's)
DM type 1
Opsonization - neutralization and complement activation
Neisseria bacteremia

21. Which immunoglobulin is a pentamer
CD21
IgM
Superficial inguinal pectinate line
B cell localization and proliferation

22. What is the main function of IgA
SLE
Prevents attachment of bacteria and viruses to mucous membranes
Corticomedullary junction
Common variable immunodeficiency (CVID)

23. What interferes with viruses?
Steroid - responsive nephrotic syndrome
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
SCID
C5b -9

24. How do NK cells kill?
Selective Ig def - IgA most common
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
III
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

25. Defect in B cell maturation
Common variable immunodeficiency (CVID)
Chronic granulomatous disease
Mixed connective tissue disease
Poly/dermato myositis

26. Cell surface receptors on T cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
B cell localization and proliferation
CD8 cells
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

27. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Neisseria bacteremia
DiGeorge
Fc

28. What does a deficiency in C5- C8 lead to?
Goodpastures
Hashimotos
Scleroderma CREST
Neisseria bacteremia

29. What are the cytokines involved in macrophage/lymphocyte interaction
SLE
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
III
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

30. What is the difference in antigenic variation in viruses
Major shift minor drift
Primary biliary cirrohosis
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
CD56

31. How many signals are required for T cell activation or B cell class switching?
IL-12 def
2
Right arm and right half of head
Pernicious anemia (to B12 def) - hashimotos thyroiditis

32. anti SS A/B or anti Ro/La

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33. Defect in DNA repair enzymes
Ataxia telangectasia
IL-10
Drug induced lupus
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

34. What kind of hypersens rxn in anaphylaxis
I
C5b -9
IgM
Bruton's agamma

35. What are the two signals in helper T activation?
Ceilac disase
SLE
Wegeners granulomatosis
Signal 1 = APC - signal 2 = B7 and CD28

36. How are NK cells stimulated?
Secondary
SLE
Howell - Jolly bodies - Target cells - thrombocytosis
IL-12 - IFN- beta. IFN- alpha

37. Which is the receptors for EBV?
Howell - Jolly bodies - Target cells - thrombocytosis
CD21
Upper limb and breast
Everything else - not right arm and right half of head

38. Which bacteria secrete superantigen
Pemphigus vulgaris
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IFN gamma
S. aureus and S. pyogenes

39. c - ANCA
Il -4
Bruton's agamma
Wegeners granulomatosis
IL-12 - IFN- beta. IFN- alpha

40. T cell dysfunction
IgG
Chronic mucocutaneaous candidiasis
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Everything else - not right arm and right half of head

41. ANA
SLE - nonspecific
Sjorgen's syndrome
Macs - dendritic cell - B cell
Selective Ig def - IgA most common

42. HLA- B8

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43. antigliadin - antiendomysial
Prevents attachment of bacteria and viruses to mucous membranes
Ceilac disase
Hashimotos
IgG

44. What does the thoracic duct drain?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Hyper IgE syndrome (Job's)
Hyper IgM
Everything else - not right arm and right half of head

45. Which antibodies activate the classic pathway
DM type 1
IgG - IgM GM makes classic cars
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
Trypanosomes - programmed rearrangement

46. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Sjorgen's syndrome
IFN gamma
IgG

47. What is the unique cell marker for NK cells
Signal 1 = APC - signal 2 = B7 and CD28
Right arm and right half of head
CD56
IgG

48. Which cell mediates the type IV hypersens rxn?
Help B cells make antibody - secrete IFN gamma to activate macs
CD8 cells
Everything else - not right arm and right half of head
Steroid - responsive nephrotic syndrome

49. What does a deficiency in C3 lead to...
DiGeorge
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Il -4
IgE

50. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
III
Trypanosomes - programmed rearrangement
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

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Immunology

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