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Immunology

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Which type of hypersens rxn is immune complex mediate
Scleroderma diffuse
DM type 1
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
III

2. What are the 4 T's of type IV hypersense
2
IgM and IgD
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Ceilac disase

3. Which cytokine inhibits Th1 cells
IL-10
Ataxia telangectasia
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
Prevents attachment of bacteria and viruses to mucous membranes

4. What are the 3 funxtions of antibodies?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Opsonization - neutralization and complement activation
B cell localization and proliferation
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

5. What kind of bacteria do macrophages remove from the spleen?
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Scleroderma CREST
IL-10
III

6. Which type of hypersens rxn is delayed
IL-4 - 5 - 10
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
2
IV

7. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
CD8 cells
IV
Leukocyte adhesion deficiency type 1
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant

8. Which infections require administering passive immunity?
III
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
IgG
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

9. Which antibodies activate the classic pathway
Autoimmune hepatitis
IL-2 and IFN gamma
IgG - IgM GM makes classic cars
All nucleated cells (no RBCs) A - B - C

10. Which bacteria secrete superantigen
Major shift minor drift
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Scleroderma CREST
S. aureus and S. pyogenes

11. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
III
Steroid - responsive nephrotic syndrome
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

12. Which is the receptors for EBV?
CD21
Steroid - responsive nephrotic syndrome
I
Hereditary angioedema

13. which kind of immunity is characterized by receptors that undergo VDJ recombination?
B cell localization and proliferation
Adaptive
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Hyper IgE syndrome (Job's)

14. Defect in LFA-1 integrin CD18 protein on phagocytes
IgG - IgM GM makes classic cars
Autoimmune hepatitis
DM type 1
Leukocyte adhesion deficiency type 1

15. How do NK cells kill?
C5b -9
PMNs recruited by IL-8 to clear infxns
RA - DM type 1
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

16. How many signals are required for T cell activation or B cell class switching?
Upper limb and breast
2
DM type 1
C5b -9

17. Which portion of the antibody determines the isotype
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Superficial inguinal pectinate line
Fc
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

18. anti glutamate decarboxylase
DM type 1
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Bruton's agamma
IgG

19. What do you find in the medulla of the thymus?
All nucleated cells (no RBCs) A - B - C
Mature t cells - epithelial reticular cells - Hassalls corpuscles
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
C3b

20. Which lymph node drains the anal canal below
RA - DM type 1
C3b
Superficial inguinal pectinate line
IFN gamma

21. Which cell mediates the type IV hypersens rxn?
CD8 cells
SLE
Mesenchyme
Chronic granulomatous disease

22. HLA- D2

23. anti SS A/B or anti Ro/La

24. Antihistone
IgA
Right arm and right half of head
Drug induced lupus
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

25. What interferes with viruses?
Innate
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Bruton's agamma
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

26. What cytokines to Th2 cells secrete?
Steroid - responsive nephrotic syndrome
IL-4 - 5 - 10
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

27. Which immunoglobulin is a pentamer
All nucleated cells (no RBCs) A - B - C
APCs - and DR - DP and DQ
Mixed connective tissue disease
IgM

28. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Help B cells make antibody - secrete IFN gamma to activate macs
Pemphigus vulgaris
Hereditary angioedema

29. Which type of hypersens rxn is serum sickness?
II
IL-12
III
Pemphigus vulgaris

30. What is the unique cell marker for NK cells
Graves' dz
Howell - Jolly bodies - Target cells - thrombocytosis
CD56
Leukocyte adhesion deficiency type 1

31. Cell surface receptors on B cels
Chronic: fibrosis of graft tissue and blood vessels
Howell - Jolly bodies - Target cells - thrombocytosis
Superficial inguinal pectinate line
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

32. HLA- DR3
Neisseria bacteremia
CD8 cells
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
DM type 1

33. What does the Th2 response do?
Regulates the humoral response
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Fab
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

34. Transplant rejection: preformed host antibody mediated
Hyperacute : occlusion - ischemia - necrosis
Wegeners granulomatosis
Hashimotos
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

35. Antimitochondrial
PMNs recruited by IL-8 to clear infxns
IV
Primary biliary cirrohosis
Innate

36. What inhibits Th2 cells
IL-4 - 5 - 10
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IFN gamma
SLE - nonspecific

37. What is the clinical picture for serum sickness?
SLE
Hereditary angioedema
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

38. Which antibody mediates a type Hypersens rxn?
Upper limb and breast
Corticomedullary junction
IgE
Opsonization - neutralization and complement activation

39. anti U1 RNP
Mixed connective tissue disease
IgE
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Other vasculitidies

40. p - ANCA
Signal 1 = APC - signal 2 = B7 and CD28
Other vasculitidies
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
I

41. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
APCs - and DR - DP and DQ
SLE - nonspecific
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Chronic mucocutaneaous candidiasis

42. What embryologic tissue are lymphcytes derived from
Hyper IgE syndrome (Job's)
IgE
Wegeners granulomatosis
Mesenchyme

43. How are NK cells stimulated?
SLE - nonspecific
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IL-12 - IFN- beta. IFN- alpha
Other vasculitidies

44. decreased Th1 response
CD56
Perforin - granzyme - granulysin
IL-12 def
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

45. c - ANCA
SLE
Hemochromocytosis
Wegeners granulomatosis
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

46. What is the arthus rxn?
DM type 1
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
IL-2 and IFN gamma
Poly/dermato myositis

47. Cell surface receptors on T cells
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
CD21
SLE
Graves' dz

48. thwat does the Right lymphatic duct drain?
Right arm and right half of head
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Chediak Higashi

49. anti basement membrane
Hashimotos
Scleroderma diffuse
Goodpastures
Chronic: fibrosis of graft tissue and blood vessels

50. What does the thoracic duct drain?
III
Primary biliary cirrohosis
IgG
Everything else - not right arm and right half of head