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Immunology

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1. Which antibody mediates a type Hypersens rxn?
IgE
Fab
Goodpastures
IL-4 - 5 - 10

2. How are NK cells stimulated?
IL-12 - IFN- beta. IFN- alpha
I
CD40 and CD40L
RA

3. antigliadin - antiendomysial
Il -4
Ceilac disase
Other vasculitidies
Corticomedullary junction

4. Which MHC complex to CD4 cells bind
Everything else - not right arm and right half of head
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
MHC II 4 x 2=8

5. Antimitochondrial
Drug induced lupus
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IV
Primary biliary cirrohosis

6. What do superantigens do?
IgG
Upper limb and breast
Hyperacute : occlusion - ischemia - necrosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

7. Which type of hypersens rxn is serum sickness?
Ceilac disase
III
Howell - Jolly bodies - Target cells - thrombocytosis
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II

8. c - ANCA
Ataxia telangectasia
Wegeners granulomatosis
Mixed connective tissue disease
Innate

9. Anti ds DNA - anti Smith
SLE
Everything else - not right arm and right half of head
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Autoimmune hepatitis

10. Antihistone
Leukocyte adhesion deficiency type 1
SLE
Howell - Jolly bodies - Target cells - thrombocytosis
Drug induced lupus

11. Th cells don't produce IFN gamma - no PMN response

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12. Cell surface receptors on B cels
IgM
DM type 1
Corticomedullary junction
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7

13. Defect in DNA repair enzymes
All nucleated cells (no RBCs) A - B - C
Selective Ig def - IgA most common
IgE
Ataxia telangectasia

14. HLA- B27

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15. Where is MHC I expressed - and which HLA molecules code for it
Help B cells make antibody - secrete IFN gamma to activate macs
Paracortex
III
All nucleated cells (no RBCs) A - B - C

16. HLA- A3
All nucleated cells (no RBCs) A - B - C
Hemochromocytosis
Wegeners granulomatosis
IFN gamma

17. Which immunoglobulin is a pentamer
No - peptides only can can be presented on MHC molecules
IgM
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Hyper IgM

18. How do CD8 cells kill?
Perforin - granzyme - granulysin
Scleroderma CREST
Mixed connective tissue disease
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

19. What are the cytokines involved in macrophage/lymphocyte interaction
IL-12
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
SCID

20. What interferes with viruses?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
III
Autoimmune hepatitis
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

21. What does the thoracic duct drain?
Chediak Higashi
Pemphigus vulgaris
Everything else - not right arm and right half of head
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

22. What is the clinical picture for serum sickness?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Primary biliary cirrohosis
RA
IL-4 - 5 - 10

23. What inhibits Th2 cells
IFN gamma
IL-10
Poly/dermato myositis
Pernicious anemia (to B12 def) - hashimotos thyroiditis

24. Which lymph node drains the anal canal below
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Superficial inguinal pectinate line
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

25. What are the 3 funxtions of antibodies?
Hyper IgE syndrome (Job's)
Opsonization - neutralization and complement activation
C5b -9
Il -4

26. antismooth muscle
Paracortex
Autoimmune hepatitis
Chediak Higashi
IgG

27. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
Chediak Higashi
Other vasculitidies

28. HLA- B8

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29. Anti - IgG (RF)
RA
I
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Poly/dermato myositis

30. Which type of hypersens rxn is immune complex mediate
III
RA - DM type 1
Chronic granulomatous disease
S. aureus and S. pyogenes

31. What does a deficiency in C1 esterase inhibitor lead to?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
MHC I
Hashimotos
Hereditary angioedema

32. anti U1 RNP
Il -4
Neisseria bacteremia
Mixed connective tissue disease
MHC I

33. Which bacteria secrete superantigen
CD8 cells
S. aureus and S. pyogenes
Chediak Higashi
Chronic: fibrosis of graft tissue and blood vessels

34. T cell dysfunction
Ataxia telangectasia
Sjorgen's syndrome
IL-10
Chronic mucocutaneaous candidiasis

35. Which parts of the antibody to heavy chain contribute?
Drug induced lupus
IL-12 - IFN- beta. IFN- alpha
Fc and Fab
Autoimmune hepatitis

36. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
CD14
Mixed connective tissue disease
IgE

37. What is the difference in antigenic variation in viruses
MS - hay fever - SLE - goodpasture's
Major shift minor drift
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Drug induced lupus

38. What does clean up on Aisle 8 stand for?
PMNs recruited by IL-8 to clear infxns
IL-10
No - peptides only can can be presented on MHC molecules
S. aureus and S. pyogenes

39. What are the two signals in cytotoxic T cells activation?
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2
Hyper IgE syndrome (Job's)
CD21
C5b -9

40. anti glutamate decarboxylase
Corticomedullary junction
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
C3b
DM type 1

41. p - ANCA
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Other vasculitidies
Upper limb and breast
Mixed connective tissue disease

42. How do NK cells kill?
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
B cell localization and proliferation
Sjorgen's syndrome
Perforins and granzymes to induce apoptosis of virally infected or tumor cells

43. Which MHC complex to CD8 cells bind
MHC I
Sjorgen's syndrome
Hereditary angioedema
Perforin - granzyme - granulysin

44. Lack of NADPH oxidase - decreased in ROS - absetn respiratory burst in PMNs
III
Fab
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Chronic granulomatous disease

45. anti - Jo 1
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Poly/dermato myositis
IFN gamma
Leukocyte adhesion deficiency type 1

46. Which immunoglobulin is found in breast milk - tears - saliva - and mucous
APCs - and DR - DP and DQ
IgA
DiGeorge
Trypanosomes - programmed rearrangement

47. which areas of the body are drained by the celiac lymph node?
I
Stomach
IgA
Everything else - not right arm and right half of head

48. antimicrosomal - antithyroglobulin
Other vasculitidies
Stomach
Hashimotos
Trypanosomes - programmed rearrangement

49. Which kind of immunity is germline encoded?
Innate
Howell - Jolly bodies - Target cells - thrombocytosis
RA
CD21

50. What is the role of CD4 cels
Help B cells make antibody - secrete IFN gamma to activate macs
MS - hay fever - SLE - goodpasture's
IL-2 and IFN gamma
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b

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Immunology

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