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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. antimicrosomal - antithyroglobulin
Hyperacute : occlusion - ischemia - necrosis
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hashimotos
CD21

2. Which cytokines to Th1 cells secrete?
III
IL-2 and IFN gamma
Selective Ig def - IgA most common
IL-4 - 5 - 10

3. What cytokines to Th2 cells secrete?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-4 - 5 - 10
Help B cells make antibody - secrete IFN gamma to activate macs
Il -4

4. HLA- B8

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5. Where do positive and negative selection occur in the thymus?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
IgE
Corticomedullary junction
CD8 cells

6. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
CD8 cells
No - peptides only can can be presented on MHC molecules
Hereditary angioedema
Steroid - responsive nephrotic syndrome

7. Which type of hypersens rxn is serum sickness?
IgM and IgD
III
Howell - Jolly bodies - Target cells - thrombocytosis
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn

8. Cell surface receptors on B cels
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Steroid - responsive nephrotic syndrome
Il -4
Scleroderma CREST

9. What does clean up on Aisle 8 stand for?
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Hyper IgM
PMNs recruited by IL-8 to clear infxns
Secondary

10. HLA- DR5
IL-12 def
Pernicious anemia (to B12 def) - hashimotos thyroiditis
IgM
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

11. decreased Th1 response
III
IL-12 def
Howell - Jolly bodies - Target cells - thrombocytosis
IL-12

12. c - ANCA
All nucleated cells (no RBCs) A - B - C
Wegeners granulomatosis
Steroid - responsive nephrotic syndrome
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein

13. Anti - IgG (RF)
IgM
RA
DM type 1
All nucleated cells (no RBCs) A - B - C

14. Which immunoglobulin is a pentamer
DM type 1
Fc and Fab
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IgM

15. Defectin in isotype switching
Selective Ig def - IgA most common
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Superficial inguinal pectinate line
IL-12 - IFN- beta. IFN- alpha

16. X- linked recessive defect with progessive deletion of B and T cells
Opsonization - neutralization and complement activation
All nucleated cells (no RBCs) A - B - C
Paracortex
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

17. HLA- DR7
Steroid - responsive nephrotic syndrome
RA
Mixed connective tissue disease
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

18. What does HOT- T- Bone stEAk stand for?
Ataxia telangectasia
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
C3b
Perforin - granzyme - granulysin

19. What do superantigens do?
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Hemochromocytosis
C5b -9
IgG

20. How are NK cells stimulated?
SLE
IgG
IL-12 - IFN- beta. IFN- alpha
Right arm and right half of head

21. Anticentromere
Scleroderma CREST
Mature t cells - epithelial reticular cells - Hassalls corpuscles
IgE
IL-12 def

22. What kind of bacteria do macrophages remove from the spleen?
Chronic mucocutaneaous candidiasis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Perforin - granzyme - granulysin
III

23. Which antibody mediates type II and type III hypersens rxn
C3b
IgG
Innate
Poly/dermato myositis

24. What are the 4 T's of type IV hypersense
Hemochromocytosis
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Ceilac disase

25. Deficiency in DAF
Corticomedullary junction
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
IgG - IgM GM makes classic cars

26. X linked recessive defect in BTK no B cell differentiation

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27. What are the three APCs
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Macs - dendritic cell - B cell
Stomach

28. What does a deficiency in C1 esterase inhibitor lead to?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
III
Drug induced lupus
Hereditary angioedema

29. What is the difference in antigenic variation in viruses
Steroid - responsive nephrotic syndrome
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Major shift minor drift
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM

30. What does a deficiency in C5- C8 lead to?
Leukocyte adhesion deficiency type 1
Upper limb and breast
All nucleated cells (no RBCs) A - B - C
Neisseria bacteremia

31. What embryologic tissue are lymphcytes derived from
Mesenchyme
MHC I
C5b -9
IgE

32. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
Chronic mucocutaneaous candidiasis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
I

33. How do NK cells kill?
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Il -4
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Superficial inguinal pectinate line

34. Which bacteria secrete superantigen
S. aureus and S. pyogenes
IgA
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
MHC II 4 x 2=8

35. Antimitochondrial
Primary biliary cirrohosis
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
IFN gamma
CD56

36. Defect in CD40L on helper T
Perforin - granzyme - granulysin
III
Leukocyte adhesion deficiency type 1
Hyper IgM

37. anti - Jo 1
Fc
Prevents attachment of bacteria and viruses to mucous membranes
Poly/dermato myositis
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

38. Where is MHC II expressed and and which HLA molecules codes for it
APCs - and DR - DP and DQ
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
RA
CD14

39. Which kind of immunity is germline encoded?
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
DM type 1
Innate

40. What are the two signals in helper T activation?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
C5b -9
Signal 1 = APC - signal 2 = B7 and CD28
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

41. What is the role of CD4 cels
Right arm and right half of head
Help B cells make antibody - secrete IFN gamma to activate macs
Other vasculitidies
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8

42. Which complement proteins make up the MAC
C5b -9
DiGeorge
Help B cells make antibody - secrete IFN gamma to activate macs
Hemochromocytosis

43. Anti Scl 70 (DNA topo I
Scleroderma diffuse
Chronic: fibrosis of graft tissue and blood vessels
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
RA - DM type 1

44. 22q11 deletion - failure of 3rd and 4th pharyngeal arches
Paracortex
DiGeorge
Hashimotos
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

45. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
Bruton's agamma
Poly/dermato myositis
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin

46. What happens in the follicle of the lymph node
Goodpastures
C5b -9
B cell localization and proliferation
IgE

47. Th cells don't produce IFN gamma - no PMN response

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48. Which MHC complex to CD4 cells bind
B cell localization and proliferation
MHC II 4 x 2=8
Wegeners granulomatosis
Hereditary angioedema

49. Which MHC complex to CD8 cells bind
MHC I
Wegeners granulomatosis
Macs - dendritic cell - B cell
DM type 1

50. What does the thoracic duct drain?
Secondary
Everything else - not right arm and right half of head
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
RA