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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Defectin in isotype switching
Mesenchyme
Goodpastures
Graves' dz
Selective Ig def - IgA most common

2. transplant rejection cell mediated due to cytotoxic t cells reacting against foreign MHCs
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate
I
Drug induced lupus
Help B cells make antibody - secrete IFN gamma to activate macs

3. Which complement protein opsonizes bacteria?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
II
C3b
All nucleated cells (no RBCs) A - B - C

4. What is the clinical picture for serum sickness?
III
IL-4 - 5 - 10
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Fab

5. thwat does the Right lymphatic duct drain?
Hashimotos
DM type 1
Perforin - granzyme - granulysin
Right arm and right half of head

6. What are the cytokines involved in macrophage/lymphocyte interaction
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
CD40 and CD40L
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
IgG - IgM GM makes classic cars

7. Can lipopolysaccharide from cell envelope of of gram neg bacteria induce immunologic memory?
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome
Trypanosomes - programmed rearrangement
Mixed connective tissue disease
No - peptides only can can be presented on MHC molecules

8. What are the three things you find post splenectomy
SCID
Howell - Jolly bodies - Target cells - thrombocytosis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Hyper IgE syndrome (Job's)

9. What do superantigens do?
IgM
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
RA - DM type 1
IL-12 def

10. Which cytokines to Th1 cells secrete?
IgE
IL-2 and IFN gamma
PMNs recruited by IL-8 to clear infxns
S. aureus and S. pyogenes

11. AR - defect in microtubule fxn with decreased phagocytosis
C5b -9
Fab
Chediak Higashi
Hyper IgE syndrome (Job's)

12. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
Hereditary angioedema
Mature t cells - epithelial reticular cells - Hassalls corpuscles
Drug induced lupus

13. Which is the most abundant immunoglobulin in the blood?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgG
IgM
Chronic granulomatous disease

14. What does HOT- T- Bone stEAk stand for?
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure
Stomach
RA - DM type 1
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA

15. which areas of the body are drained by the celiac lymph node?
C3b
Stomach
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Superficial inguinal pectinate line

16. Which is the receptors for EBV?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Upper limb and breast
Wegeners granulomatosis
CD21

17. anti SS A/B or anti Ro/La

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18. ANA
SLE - nonspecific
IgG
SLE
C5b -9

19. What do you find in the medulla of the thymus?
Mature t cells - epithelial reticular cells - Hassalls corpuscles
No - peptides only can can be presented on MHC molecules
Stomach
SLE - nonspecific

20. Which type of hypersens rxn is antibody mediated?
IgG
II
Leukocyte adhesion deficiency type 1
Paracortex

21. anti basement membrane
Goodpastures
Steroid - responsive nephrotic syndrome
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

22. HLA- B8

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23. What kind of hypersens rxn in anaphylaxis
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Pernicious anemia (to B12 def) - hashimotos thyroiditis
Howell - Jolly bodies - Target cells - thrombocytosis
I

24. What are the two signals in cytotoxic T cells activation?
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Trypanosomes - programmed rearrangement
Chronic mucocutaneaous candidiasis
Signal 1 =peptide expressed on MHC I - signal 2 = Il -2

25. Where is MHC I expressed - and which HLA molecules code for it
APCs - and DR - DP and DQ
All nucleated cells (no RBCs) A - B - C
Leukocyte adhesion deficiency type 1
Right arm and right half of head

26. antimicrosomal - antithyroglobulin
Stomach
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Hashimotos
SLE

27. Which areas of the body are drained by the axillary lymph node
Chediak Higashi
Scleroderma diffuse
Upper limb and breast
Chronic mucocutaneaous candidiasis

28. Which infections require administering passive immunity?
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IL-12
Hyper IgM

29. What is the difference in antigenic variation in viruses
Primary biliary cirrohosis
III
Major shift minor drift
PAIR - psoriasis - ankylosing spondylitis - inflammatory bowel dz - reiter's syndrome

30. anti glutamate decarboxylase
III
Poly/dermato myositis
IgG
DM type 1

31. Which cytokine induces Th1 cell profile in CD4 cells
Chronic granulomatous disease
Hashimotos
IL-12
C5b -9

32. How do NK cells kill?
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Trypanosomes - programmed rearrangement
Superficial inguinal pectinate line
Steroid - responsive nephrotic syndrome

33. HLA- A3
CD3 - CD28 - helper t - CD4 - CD40L - cyto t CD8
Hemochromocytosis
Pernicious anemia (to B12 def) - hashimotos thyroiditis
III

34. What does a deficiency in C5- C8 lead to?
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
IV
Neisseria bacteremia
CD21

35. Anti - IgG (RF)
Secondary
Chediak Higashi
RA
Other vasculitidies

36. Which parts of the antibody to heavy chain contribute?
Mixed connective tissue disease
Fc and Fab
Autoimmune hepatitis
RA - DM type 1

37. transplant rejection: grafted immunocompetent T cells from donor proliferate and attack host cells
Fab
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Graft versus host: severe organ dysfunction - maculopapular rash - jaundice - hepatosplenomegaly - diarrhea often in bone marrown and liver transplant
Goodpastures

38. Which cytokine induces Th2 cell profile in CD4 cells
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Il -4
Macs - dendritic cell - B cell
Mature t cells - epithelial reticular cells - Hassalls corpuscles

39. Which type of hypersens rxn is immune complex mediate
IL-12 def
Regulates the humoral response
Fab
III

40. Th cells don't produce IFN gamma - no PMN response

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41. Defect in B cell maturation
Primary biliary cirrohosis
Stomach
Common variable immunodeficiency (CVID)
IgG

42. Which area of the lymph node englarges in an extreme immune response
Paracortex
Scleroderma diffuse
RA - DM type 1
IgG

43. Which B T cell interaction allows for immunologic memory and class switching?
CD40 and CD40L
Fc
Ataxia telangectasia
2

44. What are the two signals required for B cells class switching?
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell
Paracortex
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

45. Which parts of the antibody to light chain contribute
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Fab
III
Pemphigus vulgaris

46. Which immunoglobulin is a pentamer
Drug induced lupus
IFN gamma
APCs - and DR - DP and DQ
IgM

47. Antimitochondrial
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IL-4 - 5 - 10
III
Primary biliary cirrohosis

48. X linked recessive defect in BTK no B cell differentiation

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49. decreased Th1 response
III
Steroid - responsive nephrotic syndrome
IL-12 def
IL-4 - 5 - 10

50. antidesmoglein
Hashimotos
Howell - Jolly bodies - Target cells - thrombocytosis
Right arm and right half of head
Pemphigus vulgaris