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Immunology

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What happens in the follicle of the lymph node
SLE - nonspecific
B cell localization and proliferation
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
IL-10

2. What are the two signals required for B cells class switching?
S. aureus and S. pyogenes
Sjorgen's syndrome
Corticomedullary junction
Signal 1 = IL-4 -5 -6 signal 2 = CD40 receptor on b cell binds CD40L on Th cell

3. What does a deficiency in C3 lead to...
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Severe pyogenic sinus and respiratory infections - inc suscept to type III hypersen rxn
Opsonization - neutralization and complement activation
APCs - and DR - DP and DQ

4. What are the cytokines involved in macrophage/lymphocyte interaction
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Signal 1 = APC - signal 2 = B7 and CD28
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement
Steroid - responsive nephrotic syndrome

5. p - ANCA
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho
Poly/dermato myositis
Other vasculitidies
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly

6. Which areas of the body are drained by the axillary lymph node
Upper limb and breast
RA
No - peptides only can can be presented on MHC molecules
Macs - dendritic cell - B cell

7. What is the unique cell marker for NK cells
Selective Ig def - IgA most common
Chronic: fibrosis of graft tissue and blood vessels
CD56
CD40 and CD40L

8. How many signals are required for T cell activation or B cell class switching?
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
2
Drug induced lupus
All nucleated cells (no RBCs) A - B - C

9. Which B T cell interaction allows for immunologic memory and class switching?
Fc and Fab
RA
Il -4
CD40 and CD40L

10. Which infections require administering passive immunity?
Major shift minor drift
Tetanus - Botulinum toxin - HBV or Rabies (To Be Healed Rapidly
Autoimmune hepatitis
Perforin - granzyme - granulysin

11. antismooth muscle
Other vasculitidies
IL-12 def
CD14
Autoimmune hepatitis

12. What does the thoracic duct drain?
Everything else - not right arm and right half of head
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
Opsonization - neutralization and complement activation
CD56

13. Which complement protein opsonizes bacteria?
RA - DM type 1
C3b
Hemochromocytosis
Acute: vasculitis of graft vessels and interstitial lymphcytic infiltrate

14. What are the 3 funxtions of antibodies?
Opsonization - neutralization and complement activation
Regulates the humoral response
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Leukocyte adhesion deficiency type 1

15. Which cytokine induces Th1 cell profile in CD4 cells
IL-12
CD14
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
IgE

16. Which bacteria secrete superantigen
S. aureus and S. pyogenes
DiGeorge
C5b -9
Everything else - not right arm and right half of head

17. Which parts of the antibody to light chain contribute
Fab
Hashimotos
II
Pemphigus vulgaris

18. Antimitochondrial
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Major shift minor drift
Primary biliary cirrohosis
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells

19. Which antibody mediates a type Hypersens rxn?
III
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
IgE

20. HLA- B8

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21. Which type of hypersens rxn is delayed
Hyper IgE syndrome (Job's)
IV
Help B cells make antibody - secrete IFN gamma to activate macs
Right arm and right half of head

22. transplant rejection: T cell and antibody mediated vasular damage
Chronic: fibrosis of graft tissue and blood vessels
Superficial inguinal pectinate line
DM type 1
Macs - dendritic cell - B cell

23. HLA- DR3
Uncoordinated release of IFN gamm leading to IL-1 - IL 6 and TNF alpha from MACS - via crosslinking of TCR and MHC II
IgE
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
DM type 1

24. Which immunoglobulin is a pentamer
IgM
Hashimotos
Corticomedullary junction
Leukocyte adhesion deficiency type 1

25. Which lymph node drains the anal canal below
Superficial inguinal pectinate line
CD56
Major shift minor drift
Opsonization - neutralization and complement activation

26. How are NK cells stimulated?
MS - hay fever - SLE - goodpasture's
Regulates the humoral response
IL-12 - IFN- beta. IFN- alpha
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

27. HLA- A3
Drug induced lupus
Hemochromocytosis
MHC II - B7 - CD40 - CD14 - receptors for Fc and C3b
Opsonization - neutralization and complement activation

28. Which MHC complex to CD8 cells bind
Ataxia telangectasia
MHC I
Salmonella - 2 flaggellar variants - Borrelia - relapsing fever - N. gono - pilus protein
IFN gamma from lymph activate MAC - IL-1 and TNF alpha from MAC activate lympho

29. How do NK cells kill?
DM type 1
Ig - CD19 - 20 - 21 - CD40 - MHCII - B7
Perforins and granzymes to induce apoptosis of virally infected or tumor cells
Signal 1 = APC - signal 2 = B7 and CD28

30. Defect in LFA-1 integrin CD18 protein on phagocytes
CD21
Wegeners granulomatosis
Help B cells make antibody - secrete IFN gamma to activate macs
Leukocyte adhesion deficiency type 1

31. Deficiency in DAF
Selective Ig def - IgA most common
IL-4 - 5 - 10
Common variable immunodeficiency (CVID)
Complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

32. anti SS A/B or anti Ro/La

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33. What are the three APCs
DM type 1
Macs - dendritic cell - B cell
IL-12 - IFN- beta. IFN- alpha
Prevents attachment of bacteria and viruses to mucous membranes

34. T cell dysfunction
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
IgM and IgD
Leukocyte adhesion deficiency type 1
Chronic mucocutaneaous candidiasis

35. Which antibody mediates type II and type III hypersens rxn
IL-2 and IFN gamma
IgG
Major shift minor drift
RA

36. Antihistone
SCID
Signal 1 = APC - signal 2 = B7 and CD28
Scleroderma CREST
Drug induced lupus

37. HLA- DR4
Regulates the humoral response
Drug induced lupus
RA - DM type 1
Chronic: fibrosis of graft tissue and blood vessels

38. Which antibodies activate the classic pathway
Interfereon alpha - beta gamma. Alpha/beta inhibit viral protein synthesis - gamma upregulate MHC I and II - all three activate NK cells
III
IgG - IgM GM makes classic cars
IgE

39. What does HOT- T- Bone stEAk stand for?
S. aureus and S. pyogenes
Opsonization - neutralization and complement activation
IL-1 = fever - IL-2 = T cells - IL-3 = bone marrow - IL-4 = IgE - IL-5 = IgA
Signal 1 = APC - signal 2 = B7 and CD28

40. What is the arthus rxn?
Leukocyte adhesion deficiency type 1
Macs - dendritic cell - B cell
PMNs recruited by IL-8 to clear infxns
Type III hypersens rxn after intradermal rxn with antigen - antibodies in the skin causing edema - necrosis and activation of complement

41. AR - defect in microtubule fxn with decreased phagocytosis
Corticomedullary junction
Wilskott Aldrich (TIE = thrombocytopenia - infections - eczema) high IgE and IgA - low IgM
Common variable immunodeficiency (CVID)
Chediak Higashi

42. What kind of bacteria do macrophages remove from the spleen?
Adaptive
Encapsulated - S SHiN (salmonella - S.pneumo - H. influ - N. menin
RA - DM type 1
Other vasculitidies

43. Which portion of the antibody determines the isotype
S. aureus and S. pyogenes
Fc
Hyper IgM
CD8 cells

44. Defectin in isotype switching
Graves' dz
DM type 1
Selective Ig def - IgA most common
Caused by drugs mostly - fever - urticaria - arthralgias - proteinuria - lymphadenopathy 5-10 days after exposure

45. What is the role of CD4 cels
SLE - nonspecific
IL-12
RA
Help B cells make antibody - secrete IFN gamma to activate macs

46. antidesmoglein
T- lymphos - Transplant - TB skin test - Touching (contact dermatitis)
Il -4
Pemphigus vulgaris
IL-12 - IFN- beta. IFN- alpha

47. Anticentromere
SCID
Fab
Scleroderma CREST
Leukocyte adhesion deficiency type 1

48. X linked recessive defect in BTK no B cell differentiation

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49. HLA- DR7
IL-2 and IFN gamma
IL-12 def
Steroid - responsive nephrotic syndrome
IgE

50. What inhibits Th2 cells
Hyperacute : occlusion - ischemia - necrosis
All nucleated cells (no RBCs) A - B - C
IFN gamma
IgA