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Test your basic knowledge |
Microbiology
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Subject
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engineering
Instructions:
Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Which bacteria don't stain well because they are too thin to be visualized
complex virus example
Catalase pos microbes - S. aureus - Nocardia - aspergillus
Treponema
M. avium intracellulare
2. What is Anti - HBeAg
ADP- R AB toxin: heat labile - stimulates adenylate cylcase - heat stable toxin stimulates guanylate cyclase - both cause watery diarrhea
Schistosoma - snail - cercariae penetrate skin of humans - praziquantrl
Antibody to HBeAg - indicates low transmissability
Palivizumab
3. Mitosis and meiosis + cytokinesis
replication for eukaryotes
penetration (AV)
Tetracycline or erythromycin
mycology
4. Tularemia - tick bite - rabbits and deer
Francisella tularenis
Generalized transduction - a packaging event
Bullet shaped capsid - long incubation period before sx onset
cell wall - function
5. How is legionella detected clinically
Pseudomonas
Serratia marcescens
Antigen in urine
Beta hemolytic
6. what bug grows on charcoal yeast extract agar buffered with cysteine
Shiga like toxin - botulinum toxin - cholera toxin - diptheria toxin - erythrogenic toxin of s. pyogenes
gram- negative stain - color
Legionella
Schistosoma - snail - cercariae penetrate skin of humans - praziquantrl
7. 70S = 30S + 50S
ribosomes (prokaryotic) - size
Candida albicans
Ring enhancing brain lesions
Vulvuvaginitis
8. What components make up the eveloped helical viral structure
Dipicolinic acid
Phenotypic missing - infectivity of type B - progeny will of second infection will have coat from virus A
Surface protein - matrix/core protein - lipid bilayer - nucleic acid and nucleocapsid protein
Chronic - cirrhosis - carcinoma - carriers
9. What OI/disease occurs in the mouth and throat of AIDS pts
Thursh - HSV - CMV - oral hairy leukoplakia from EBV
Yellow fever - dengue - st. louis encephalitis - west nile virus - HCV not
Oral thrush - tinea pedis - reactivation VZV - reactivation TB - bacterial infxns (H flu - S pneumo - Salmonella)
HBsAg - HbeAg - and IgG Anti - HBcAg
10. How do group B strep respond to bacitracin
virus example
Resistant
Rheumatic fever - acute glomerulonephritis
Streptococcus - staphylococus
11. What are possible sequelae of measles infxn
SHiN - strep pneumo - h flu - neisseria
Papilloma - polyoma - hepadnavirus
Subacute sclerosing panencephalitis is rare - and giant cell PNA in immunoCised
basic shapes of bacteria
12. cestode causing intestinal tapeworms - org - transmission - tx
Prevents phagocytosis - group A strep
cytoplasm - definition
Diarrhea in children - no toxin - adheres to apical surface - flattens villi - prevents absorption
Taenia solium - ingestion of larvae encysted in undercooked pork - praziquantel
13. 1668 - Attempted to disprove spontaneous generation
Actinomyces isreallii
three domains of microorganisms
Surface protein - lipid bilayer - capsid - nucleic acid
Francesco Redi
14. Plague - flea bite - rodents esp prarie dogs
Double zone of hemolysis
basic shapes of bacteria
Yersinia pestis
Cytoplasmic inclusions seen on giemsa stain or fluorescent antibody- stained smear
15. Intestinal flora that causes lobar pneumonia in alcoholics and diabetics when aspirated
Klebsiella
SNAP - sulfa for nocardia and actinomyces get pen
Doxycycline
A lipopolysaccharide found in the outer membrance of gram neg bacteria
16. Patient serum mixed with proteus antigen - and anti - rickettsial antibodies cross react to proteus O antigen and agglutinate
myc/myo means
Malaria - plasmodium - anopheles - blood smear - cholorquine - resistant use mefloquine and for vivax/ovale add primaquine for dormant forms
Weil Felix test
Gives rigid support - protects against osmotic pressure - sugar backbone with cross linked peptide side chains
17. Osteomyelitis in diabetics and drug addicst
Pseudomonas
Francisella tularenis
Group B strep - E. coli - listeria
Francesco Redi
18. Obligate intracellular parasites - most can infect cells of only one host species
viruses
Severe - daily cycles - parasitized RBCs occlude capillaries in the brain - kidneys and lungs
gram- negative cell wall
Aminoglycoside plus extended spectrum pen (pipercillin - ticarcillin)
19. What is the fxn and chemical composition of bacterial spore
Vanc resis enterococci and are important cause of nosocomial infection
Heat labile toxin
Ebolo/marburg - hemorrhagic fever - often fatal
Provides resistance to dehydration - heat and chemicals; keratin like coat; dipicolinic acid
20. Study of bacteria
Viridans group streptococci
Cell Theory
bacteriology
Neisseria
21. Surrounds the capsid in some viruses
Foul smelling (short chain fatty acids) - difficult to culture - produce gas in tissues (CO2 - H2)
S. aureus and S. epidermidis
ADP- R AB toxin - inactivates EF-2; causes pharyngitis and pseudomembrane in the throat (similar to pseudomonas exotoxin A)
envelope - definition
22. What kind of virus and family are HBV
DNA hepadnavirus
Gardnerella vaginalis
Malignant otitis externa
Beta hemolytic
23. What kind of exotoxin does bordetella pertussis have and What does it do
Silver stain
ADP- R AB toxin: inc cAMP by inhibiting Galpha1 - causes whooping cough - inhibits chemokine receptor - causing lymphocytosis
Aedes mosquitos with monkey or human resevoir -; high fever - black vomitus - and jaundice
virology
24. What do you see on blood agar with C. perfringens
Sterility
Epiglottitis H flu type B
CXCR4 on CD4 cells - CCR5 on CD4 and MACS - homozygous CCRF mutation confer immunity - CCR5 heterozygoes have slower course
Double zone of hemolysis
25. What neisseria is there a vaccine for
The first 3 act via ADP ribosylation causing permenately activating adenylate cyclase - while anthrax edema factor is itself an adenylate cyclase causing an inc in cAMP
Coxsackie A - hand - foot - mouth dz
Meningococci
Pox - carries own DNA dependent RNA polymerase
26. What does pertusses toxin do to Gi
Permanently disables causing whooping cough via induction of cAMP - turns the off off
Food - fingers - feces - flies
HPV - warts (1 - 2 - 6 - 11) - CIN - cervical cancer (16 - 18) vaccine available
Saprohyticus resistant - epidermidis is sensitive - NO StRES
27. Why are chlamydiae obligate intracellular
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28. What are the signs of viral hepatitis
Episodes of fever - jaundice and inc AST/ALT
MRSA - resistant to beta lactams due to altered penicillen binding protein
Cryptococcus neoformans
Gardnerella vaginialis and bacterial vaginosis
29. How do you distinguish EHEC from other kinds of E. Coli
Cough - coryza - conjunctivitis
Actinomyces
Gingivostomatitis - keratoconjunctivitis - temporal lobe encephalitis - herpes labialis - respiratory secretions - saliva
Does not ferment sorbitol
30. What organisms stain with india ink
Infectious = most of dsDNA (not pox/HBV) (+) strand ssRNA (same as mRNA); non infecitious = (-) ssRNA - dsRNA
In pregs - amnionitis - septicemia - spontaneous abortion - granulomatous infantiseptica - neonatal meningitis in neonates - immunoCised - meningitis - healthy people - mild gastroenteritis
protozoa means of locomotion (3)
Cryptococcus neoformans
31. What toxins does S. aureus secrete
Enterotoxins - TSST-1 - exfoliatin which causes scalded skin syndrome
plasmid - function
Klebsiella
S. pneumo - Influenza virus - anaerobies - H flu - GNR
32. Where doe HSV1 cells remain latent
Enterobius
Trigeminal ganglia
Rickettsia rickettsii
Mediate adherence of bacteria to cell surface;sex pilus forms attachment between 2 bacteria during conjugation - glycoprotein
33. What is the TX for candidiasis
Ten times - shorter urethrase colonized by fecal flora - obstruction - kidney surgery - catheterization - GU malformation - diabetes pregnancy
Nystatin for superficial - ampho B for systemic
Resistant to destruction by heat or chemicals - need to autoclave to kill by steaming at 121C for 15 minutes
Transcribe negative strand to positive - RNA dependent RNA polymerase
34. What kind of paralysis does tetanus toxin produce
Spastic - trismus (lockjaw and risus sardonicus)
Koch's Postulates 3
Malaria - plasmodium - anopheles - blood smear - cholorquine - resistant use mefloquine and for vivax/ovale add primaquine for dormant forms
Enteroinvasive E. coli
35. Water movement with hypotonic solution or hypertonic solution
protista kingdom
Candida and aspergillus
osmotic pressure
humans do not have
36. No metabolic activity
Coagulation cascade - DIC
CMV retinitis and esophagitis - disseminated M avium intracellulare - cryptococcal meningoencephalitis
Posterior cervical lymph nodes
dormant
37. What is the TX for leprosy and What is the toxicity of this TX
Dapsone - hemolysis and methemoglobinemia or rifampin and combination clofazimine + dapsone
Vagina
HBsAg as envelope - can coinfect or superinfect (worse prognosis)
Aerosal - from environmental water source
38. Brain abscesses in HIV pos pts with ring enhancing lesions on imaging
Toxoplasmosis
All except coxiella are via arthropod
Gram pos rods with metachromatic (blue and red) granules
S. aureus - virulence factor - binds Fc - IgG - inhibiting complement fixation and phagocytosis
39. What are the top bugs for PID and what distinguishes them
C. trachomatis - subactue - often undiagnosed - N. gono - acute with high fever; C. trachomatis is the most common STI in the US
Parvoviridae
Active hepatitis - cirrhosis and HCC
microbiology
40. fever - lymphadenopathy - skin rashes - condylomata lata - org and dz
Treponema - 2ndary syphillis
Surfers in the tropics
Pneumonia - meningitis - sepsis in babies
S. pyogenes - toxic shock - like syndrome
41. Spaghetti and meatball appearance on KOH prep - dz - organism
Prompt oral rehydration
Pseudomonas
Tinea versicolor - malassezia furfur
Malaria - plasmodium - anopheles - blood smear - cholorquine - resistant use mefloquine and for vivax/ovale add primaquine for dormant forms
42. Spirillum - vibrio - spirochete
Oral thrush - tinea pedis - reactivation VZV - reactivation TB - bacterial infxns (H flu - S pneumo - Salmonella)
spiral
Cryptococcus - CMV - toxoplasmosis (brain abscess) - JC virus (PML)
Gram pos rods with metachromatic (blue and red) granules
43. What kind of exotoxin does V. cholerae have and What does it do
staining of bacteria
N. gonorrhea - vancomycin (inhibits gram pos) polymyxin (inhibits gram neg) - nystatin (inhibits fungi)
tetanus
ADP ribosylation of G protein stimulates adenylyl cyclase - inc Cl - secretion into gut and dec Na absorption - H20 into gut lumen - voluminous rice water diarrhea
44. ulcers - lymphadenopathy - rectal strictures - org and dz
C. trachomatis (L1- L3) - lymphgranuloma venereum
California encephalitis - sandfly/Rift Valley fevers - crimean - congo hemorrhagic fever Not - hantavirus causing hemorrhagic fever pneumonia
HBsAg - HbeAg - and IgG Anti - HBcAg
Gingivostomatitis - keratoconjunctivitis - temporal lobe encephalitis - herpes labialis - respiratory secretions - saliva
45. Opportunistic infections - KS - lymphoma - orga and dz
HBsAg - anti - HBeAb - anti - HBcAb IgG
Immediately upon exposure
polyhedral shape - defintion
HIV - AIDS
46. What are the laboratory findings for H Flu
S. aureus
they are eukaryotes
Cytoplasmic inclusions seen on giemsa stain or fluorescent antibody- stained smear
Gram neg coccobacillary rods - cultured on chocolate agar with factors V and X NAD+ and hematin OR with S. aureus
47. What is the clinical picture of rheumatic fever
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48. What is the mechanism of renal failure and thrombocytopenia in HUS
S. pneumo - H. flu type b - Neisseira - SHiN - IgA protease cleaves IgA
Endothelium swells and narrows lumen - leading to mechanical hemolysis and reduced renal blood flow - damaged endothelium consumes platelets
DNA hepadnavirus
Elementary body - small dense is infectious and enters via endocytosis -; reticulate body replicates in cell by fission - seen in tissue culture
49. Cell walls contain mycolic acid
Antiphagocytic virulence factor
Teichoic acid
acid- fast organism - definition
Unimmunised kids
50. What other organism is involved in vaginosis from gardnerella
Anaerobes
Mobiluncus - an anaerobe
Cool temps - infects skin and superficial nerves - armadillos
Metabolic activity without division
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