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Microbiology 2

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Answer 50 questions in 15 minutes.
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1. HIV - Meningitis; India ink stain reveals narrow - based budding
Lysogeny
Erythromycin
Cryptococcus neoformans
Togavirus

2. Tx for Leishmania donovani
Loa Loa
Sodium stibogluconate
Picornavirus
Invasive aspergillosis

3. Hepevirus
Toxocara canis
Amphotericin B
No envelope - SS + linear - Icosahedral
Cleaves host cell rRNA (inactivates 60S ribosome); enhances cytokine release - causing HUS.

4. Retroviruses
Picornavirus
Schistosoma
Rubella
Enveloped - SS + - Icosahedral

5. Inflammation of muscle (larvae encyst in muscle)
Diethylcarbamazine
Paramyxovirus
Babesia
Trichinella spiralis

6. Tx for Onchocerca volvulus
Retrovirus
Cleaves host cell rRNA (inactivates 60S ribosome); enhances cytokine release - causing HUS.
Mycobacterium avium - intracellulare
Ivermectin

7. RSV
Giardia lamblia
Naegleria fowleri
JC virus (PML) results in demyelination
Paramyxovirus

8. Echovirus
Fluconazole or ketoconazole
Trichinella spiralis
Arenavirus - spread by mice
Picornavirus

9. HIV - Non - hodgkin's lymphoma (large cell type); often on oropharynx (Waldeyer's ring)
EBV
Lysogeny
Clostridium difficile - gas gangrene - double zone of hemolysis on blood agar
Mycobacterium avium - intracellulare

10. 'Soap bubble' lesion in brain
Colonic epithelial cell necrosis and stimulation of fibrin deposition
Praziquantel
Cleaves host cell rRNA (inactivates 60S ribosome); enhances cytokine release - causing HUS.
Cryptococcus neoformans

11. Ebola/Marburg hemorrhagic fever
Praziquantel
Doxycycline - ceftriaxone
Aminoglycoside plus extended spectrum penicillin (piperacillin - ticarcillin)
Filovirus

12. Tx for neurocystercercosis
Bunyavirus - hemorrhagic fever - pneumonia
bendazoles
Bunyavirus
Rubella

13. Rickettsia transmitted by aerosol; no rash - no vector - neg Weil - Felix
Enveloped - SS - - circular - 3 segments - helical
Praziquantel
Coxiella burnetti
Rubeola

14. Rotavirus
Arenavirus - spread by mice
Group A beta - hemolytic strep (S. pyogenes) sensitive. Group B (S. agalactiae) resistant.
Pathognomonic for measles or live attenuated vaccine
Reovirus

15. Tx for Wuchereria bancrofti
Diethylcarbamazine
Rifampin
Entamoeba histolytica
Mucor or Rhizopus spp.

16. HIV - Hairy leukoplakia; often on lateral tongue
EBV
Babesia
Picornavirus
Toxoplasma gondii

17. Filoviruses
Enveloped - SS - - linear - Helical
Enveloped - SS - - circular - 3 segments - helical
Flavivirus
Group A beta - hemolytic strep (S. pyogenes) sensitive. Group B (S. agalactiae) resistant.

18. dsRNA segmented virus
Paragonimus westermani
P. vivax/ovale
Reovirus
Paramyxovirus

19. Transmitted by female blackflies; causes hyperpigmented skin. Can have allergic reaction to microfilaria
Bartonella henselae (bacillary angiomatosis)
C. Difficile
Mucor or Rhizopus spp.
Onchocerca volvulus

20. Fungal infection with rhinocerebral - frontal lobe abscesses
Congenital Toxoplasma gondii
Mucor or Rhizopus spp.
Onchocerca volvulus
Diethylcarbamazine

21. M protein
Group A streptococcus. Helps prevent phagocytosis.
Picornavirus
Babesia
Trypanosoma (T. gambiense - T. rhodiesiense); African sleeping sickness

22. HIV - Pneumonia CD4<200
Pneumocystis jiroveci
Pathognomonic for measles or live attenuated vaccine
S. pneumoniae sensitive - S. viridans resistant
EBV

23. Organisms causing rash on palms and soles
Coxackie A - syphilis - Rocky Mountain spotted fever
Taenid solium
Entamoeba histolytica
Colonic epithelial cell necrosis and stimulation of fibrin deposition

24. Hantavirus
S. aureus. Binds Fc region of Ig. Prevents opsonization and phagocytosis.
Babesia
Bunyavirus - hemorrhagic fever - pneumonia
Enterobius vermicularis

25. C. tetani exotoxin: Plasmid - lysogeny - bacterial chromosome?
Mucor or Rhizopus spp.
Colonic epithelial cell necrosis and stimulation of fibrin deposition
Plasmid
Trypanosoma (T. gambiense - T. rhodiesiense); African sleeping sickness

26. Tx for Taenid solium
Praziquantel
Enterobius vermicularis
Cleaves IgA. S. pneumoniae - H. influenzae type B - Neisseria (SHiN) in order to colonize respiratory mucosa.
T. pertenue

27. Tx for Babesia
Flavivirus
Quinine - clindamycin
Lysogeny
Nonenveloped - SS + - Icosahedral

28. Mucicarmine
Stains cryptococcus neoformans red
Babesia
Coxiella burnetti
Pseudomonas - inactivates EF-2

29. Western equine encephalitis
Nifurtimox
Lysogeny
Pathognomonic for measles or live attenuated vaccine
Togavirus

30. Bunyaviruses
JC virus (PML) results in demyelination
T. pertenue
Palivizumab
Enveloped - SS - - circular - 3 segments - helical

31. Paramyxoviruses
Diethylcarbamazine
Enveloped - SS - - linear - nonsegmented - Helical
Flavivirus
Enveloped - SS - - circular - helical

32. HCV
No envelope - SS + linear - Icosahedral
Diethylcarbamazine
Trypansoma cruzi. Chagas dz - S. America
Flavivirus

33. Shiga toxin
Cryptococcus neoformans
Cleaves host cell rRNA (inactivates 60S ribosome); enhances cytokine release - causing HUS.
Mycoplasma pneumonia
Paramyxoviruses

34. Generalized lymphadenopathy particularly postauricular and occipital
T. pertenue
Ivermectin
Rubella
Enveloped - SS+ - linear - icosahedral

35. Treatment for local infection by systemic mycoses
Fluconazole or ketoconazole
Cryptosporidium spp.
Rubeola
Ceftriaxone

36. Reovirus
Doxycycline - ceftriaxone
Paramyxovirus
Enterobius vermicularis
No envelope

37. Colorado tick fever
Group A streptococcus. Helps prevent phagocytosis.
Reovirus
Rubeola
Trichinella spiralis

38. Tx for Trichomonas vaginalis
Metronidazole
Group A streptococcus. Helps prevent phagocytosis.
Picornavirus
Mucor or Rhizopus spp.

39. Rash spreads from head to toe
Sodium stibogluconate
Picornavirus
Rubeola
No envelope - SS + linear - Icosahedral

40. Kala - azar: spiking fevers - hepatosplenomegaly - pancytopenia
Naegleria fowleri
Leishmania donovani
Praziquantel
Rubella

41. Echovirus
Clonorchis sinensis
Schistosoma mansoni
S. pneumoniae sensitive - S. viridans resistant
Most common cause of aseptic meningitis

42. Eaton's agar
Toxoplasma gondii
Toxocara canis
Mycoplasma pneumonia
Enveloped - SS+ - linear - icosahedral

43. Tx of Schistosoma
Praziquantel
Amphotericin B
Arenavirus
Stains cryptococcus neoformans red

44. Lassa fever encephalitis
Wuchereria bancrofti
Clonorchis sinensis
Arenavirus - spread by mice
Pseudomonas - inactivates EF-2

45. Diphtheria toxin: Plasmid - lysogeny - bacterial chromosome?
JC virus (PML) results in demyelination
Paramyxoviruses
Lysogeny
Calicivirus

46. Triad of chorioretinitis - hydrocephalus - intracranial calcifications
Enveloped - SS - - circular - 2 segments - helical
Doxycycline - ceftriaxone
Congenital Toxoplasma gondii
Coxiella burnetti

47. Severe congenital infection
Congenital rubella
Rubeola
Rubella
P. falciparum

48. Crimean - Congo hemorrhagic fever
Taenid solium
Mucor or Rhizopus spp.
Bunyavirus
Amphotericin B

49. Fever then rash
HHV-6 (Roseola)
Mycoplasma pneumonia
Diethylcarbamazine
Cleaves host cell rRNA (inactivates 60S ribosome); enhances cytokine release - causing HUS.

50. HIV - Chronic watery diarrhea; acid - fast cysts seen in stool
Topical miconazole - selenium sulfide
Enveloped - SS - - linear - Helical
Paramyxovirus
Cryptosporidium spp.

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Microbiology 2

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