Test your basic knowledge |

Musculoskeletal

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What do pseudogout crystals appear like microscopically
Axillary - deltoid - skin over deltoid - flattened deltoid
Anti Smith
Erythema nodosum
Basophilic - rhomboid crystals - weakly birefringent

2. Reduction of primarily trabecular (spongy) bone mass despite nl bone mineralization lab values
Osteoporosis
S. aureus - streptococcus
Integrin binds laminin in BM
Upper trunk compression - biceps - brachialis - corachobrachialis - flexion of arm at elbow - sensory = lateraly forearm

3. What is CREST syndrome and What antibody is it associated with
Actinic keratosis - risk proportional to epithelial dysplasia
Inc spinosum - dec granulosum
Calcinosis - raynauds - esophageal dysmotility - sclerodactyly - telangiectasia - anti centromere antibody
Scleroderma

4. What is the Sicca syndrome
Verrucae vulgaris
Inc spinosum - dec granulosum
Dry eyes - dry mouth - nasal and vaginal dryness - chronic bronchitis - reflux esophagitis and No arthritis
Interossei and adductor policis

5. What kind of injury can cause damage to the inferior gluteal nerve and What can it cause

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

6. What does MLCK do in smooth muscle contraction
Nl - thickened dense bones
NSAIDs (indomethacin) colchicine
Phosphorylates myosin light chain which leads to cross bridge formation
Conjunctivitis and anterior uveitis - urethritis and arthritis

7. What do xray show in osteopetrosis and What do potential CN abnl result from
S100 - associated with sunligh exposure - fair skinned at risk - depth of tumor correlates with risk of mets - dark with irregular borders
Vitiligo - dec number in melanocytes
Erlenmeyer flask bones that flare out - narrowed foramina
Ligand binding leads to muscle depol

8. fever - bulla formation and necrosis - sloughing of skin and high mortality - syndrome and associations
Immunoglobulins - malar rash - discoid rash - ANA - mucositis (oropharyngeal ulcers) - neurologic disorders - serositis (pleuritis - pericarditis) - hematologic disorders - arthritis - renal - photosensitivity
Stevens johnson syndrome - associated with adverse drug reactions - more severe version called toxic epidermal necrolysis
Biceps
Actin

9. Where is osteosarcoma found in the bone
SERMs - calcitonin - bisphosphates or pulsatile PTH for severe cases
Median nerve
Ribonucleoprotein antigents - SS- A and SS- B (Ro and La)
Metaphysis of long bones - distal femur

10. What antibodies is diffuse scleroderma associated with
Gout
Anti Scl70 - anti DNA topoisomerase I antibody
Paralysis of lateral rotators
MCP - PIP - no DIP

11. Through what pathway does NO work and What is the downstream effect
GC and cGMP and inhibition of MLCK
Erlenmeyer flask bones that flare out - narrowed foramina
Seborrheic keratosis
Hands and face - ulcerative red lesion - locally invasive bur rare metastasis - associated with chronic draining sinuses and keratin pearls

12. Thenar eminence - nerve and muscles
85% - advanced paternal age - or auto dominant inheritance
Pustule
Restrictive lung disease - bilateral hilar lymphadenopathy - erythema nodosum - Bell's palsy
Median - opponens pollicis - abductors pollicis brevis - flexor pollicis brevis

13. What are the characteristic bone findings in paget's disease
B27 - no RF - males
Dysplastic nevus
Mosiac bone pattern - long bone chalk stick fractures - increased hat size or hearing loss due to auditory foramen narrowing
Morning stiffness for > 30 min improving with use - symmetry - systemic sx

14. potentially fatal autoimmune disorder with IgG antibody against desmosomes
Pseudogout
Osteogenic carcinoma
Abduct the fingers
Pemphigus vulgaris

15. What causes ape hand
Defective mineralization/calcification of osteoid - osteomalacia in adults and ricketts in kids
Basal cell carcinoma - pearly papules - commonly with telangiectasias
Proximal median nerve lesion - loss of opponens pollicis muscle fxn leading to unopposoble thumb
Lesioned by midshaft fracture of humerus

16. What are the classic fractures in pts with osteoporosis

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

17. How is diffuse scleroderma characterized
Widespread skin involvment - rapid progression - early visceral involvement
After a large meal or EtOH conspumption
Expansile glistening mass within the medullary cavity
Dysplastic nevus

18. Other than N. gono - what organisms can cause infectious - septic arthritis
Staph scalded skin syndrome
Anterior interosseous nerve
Fever - fatigue - pleuritis - pericarditis
S. aureus - streptococcus

19. What lesion causes claw hand and What are the muscles involved
Posterior cord
Urticaria
Steroids
Ulnar nerve - intrinsic muscles of hand

20. epi of SLE
Anti - CCP - HLA- DR4
Defective mineralization/calcification of osteoid - osteomalacia in adults and ricketts in kids
Female between 14 and 45 - mostly black
Schaumann (calcium and protein inclusions inside Langhans giant cells) and asteroid bodies

21. What supplies innervation to the thenar muscles
Medial aspect
Recurrent branch of the median nerve
Ulnar nerve
Lichen planus

22. What nerve become injured in the incorrect use of a crutch
Scleroderma
Anti Scl70 - anti DNA topoisomerase I antibody
Radial nerve becomes compressed in axilla
Posterior hip dislocation - can't jump - climb stairs or rise from seated positions

23. larger osteoid osteoma found in vertebral column
Osteoblastoma
Adduct the fingers
Wheal
Vit D def - dec Ca - inc PTH - dec serum phos - reversible when vit D is replaced

24. What are the lab findings in osteopetrosis
Torn MCL
Median - lateral finger and wrist flexion - dorsal palmar aspects of lateral 3.5 fingers/thenar eminence - ape hand - carpal tunnel syndrome
Nl - thickened dense bones
Hairy leukoplakia - HIV population - EBV mediated

25. What variant of squamous cells carcinoma of the skin grows rapidly and regresses spontaneously
Upper trunk compression - biceps - brachialis - corachobrachialis - flexion of arm at elbow - sensory = lateraly forearm
Lesion to lower trunk of brachial plexus - loss of fxn of all lumbricals - forearm finger flexors - finger extensors are unopposed (radial nerve)
Conjunctivitis and anterior uveitis - urethritis and arthritis
Keratoacanthoma

26. What kind of jxn is in the zona adherens and Where is it - What is it composed of - and what ion does it does it depend on...
Basal cell carcinoma - pearly papules - commonly with telangiectasias
Subclavius
Intermediate jxn - just below zona occludens - cadherins and actin filaments - cadherins are dependent on Ca2+
Superior glut - thigh abduction - pos trendelenburg - hip drops when standing on the opposite foot (standing on the side of the lesion)

27. What test if specific for lupus but doesn't indicate prognosis
Radial - BEST extensors - posterior arm and dorsal hand/thumb - wrist drop
Anti Smith
Torn MCL
Vertebral crush fractures - femoral neck fractures - distal radius (Colles') fracture

28. What is the landmark for an LP
Iliac crest
Loss of medial lumbrical fxn; 4th and 5th digits are clawed - when try to open hand - pinky and ring finger stay clawed
Erythema multiforme - can be macules - papules vesicles - target lesions -
Voltage sens - dihydropiridine R coupled to ryanodine recpetor - conformational change in the SR - releasing Ca2+

29. What is the classic presentation of osteoarthritis
Acanthosis nigcricans
MCL - ACL - lateral meniscus (esp in athletes)
Pain in weight bearing joints at the end of the day and improving with rest
Thymoma

30. What is the classic traid of sjogrens syndrome
Xeropthalmia - xerostomia - arthritis
Calcinosis - raynauds - esophageal dysmotility - sclerodactyly - telangiectasia - anti centromere antibody
McCune - Albright syndrome
Anti - CCP - HLA- DR4

31. What kind of hypersens rxn is RA - and what serum marker is present in 80% of RA pts
Serum ca - phos - alk phos are NL
4th and 5th finger
Loss of medial lumbrical fxn; 4th and 5th digits are clawed - when try to open hand - pinky and ring finger stay clawed
Type III - RF

32. What causes compression of the C7 nerve root
Calcinosis - raynauds - esophageal dysmotility - sclerodactyly - telangiectasia - anti centromere antibody
3rd finger
Cervical disk lesion
Xeropthalmia - xerostomia - arthritis

33. What syndrome of the NMJ is a paraneoplastic syndrome and What are the antibodies directed against
Boutonniere - swan neck - zthumb
EtOH metabolites compete for same excretion site in kidney as uric acid - causing dec uric acid secretion and subsequent buildup
Lamber eaton - presynaptic Ca channels - dec ACH release leading to proximal muscle weakness
Myasthenia gravis - autoAb against ACH receptors causing ptosis - diplopia - general weakness -

34. What do the lumbrical muscles do
Osteoarthritis
S100 - associated with sunligh exposure - fair skinned at risk - depth of tumor correlates with risk of mets - dark with irregular borders
Urticaria
Flex at the MCP

35. What antibody is less sensitive than RF but more specific and What is the HLA association
Inc alk phos - abnl bone architecture
Anti - CCP - HLA- DR4
Ulnar
Parotid enlargement - inc risk of B cell lymphoma - dental caries

36. MG is associated with what neoplasm
Thymoma
Abduct the fingers
Sudden appearance of multiple sebhorrheic keratosis lesions indicating underlying lesions - GI or lymphoid
Lamber eaton - presynaptic Ca channels - dec ACH release leading to proximal muscle weakness

37. Who does osteoporosis type 2 effect
Median - lateral finger and wrist flexion - dorsal palmar aspects of lateral 3.5 fingers/thenar eminence - ape hand - carpal tunnel syndrome
Men and women > 70 - senile osteporosis
Intraepidermal bullae involving the skin and oral mucosa
Ulnar nerve - adduction of thumb - extension of 4th and 5th fingers (lumbricals)

38. What is below the epidermis
Type III - RF
Dorsal side of lateral hand - most of lateral surface of the thumb - no digits
Ribonucleoprotein antigents - SS- A and SS- B (Ro and La)
The dermis

39. What development failure can results in albinism
NC migration
Muslce use - nerve stim/compound muscle test
False positives on syphillis test (RPR/VRDL) due to antiphospholipid antibodies - cross react with cardiolipin
Keratoacanthoma

40. chronic inflammatory disease of sacroiliac joints and spine - dz - associations
Ligand binding leads to muscle depol
Ankylosing spondylitis - uveitis - aortic regurg and bamboo spine
Palisading
Anti - histone

41. What molecule maintatins integrity of basement membrane and What does it bind
Chondrosarcoma - pelvis - spine - scapula - humerus - tibia - or femur
Crohns and ulcerative colitis
Anti - histone
Integrin binds laminin in BM

42. In a fracture of the midshaft of the humerus - or extended compression of axilla - nerve - motor - sensory - sign
Metaphysis of long bones - distal femur
The dermis
Biceps
Radial - BEST extensors - posterior arm and dorsal hand/thumb - wrist drop

43. Which type of muscle fiber is hypertrophied during weight training
4th and 5th finger
Type 2
Middle bicep down - cuts lateral at cuboidal foass and runs distally to include the thumb and 2nd digit
Serum ca - phos - alk phos are NL

44. What are the potential causes of gout

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

45. Where is C6 dermatome
Anti - CCP - HLA- DR4
Middle bicep down - cuts lateral at cuboidal foass and runs distally to include the thumb and 2nd digit
Boutonniere - swan neck - zthumb
Radial nerve becomes compressed in axilla

46. Where is T1 dermatome
Medial forearm and arm to just under the axilla
Dec Ca - dec phos - nl alk phos - inc PTH - soft bones
Supraspinatus - abducts the arm before the deltoid
Cervical disk lesion

47. Damage to what 3 structures is common for the unhappy triad
Erlenmeyer flask bones that flare out - narrowed foramina
SERMs - calcitonin - bisphosphates or pulsatile PTH for severe cases
Obturator - thigh adduction - medial thigh
MCL - ACL - lateral meniscus (esp in athletes)

48. Which muscle laterally rotates and adducts arm
Teres minor
Mesenchymal stem cells in periosteum
3rd finger
Asymmetric - swollen - red - painful joint - often MTP (podagra) - tophus formation on external ear - olecranon bursa - achilles tendon

49. What is the primary screening test for lupus
Posterior cord
2/3 of the way from the umbilicus to the anterior superior iliac spine - appendix
ANA - sensitive but not specific
Torn MCL

50. knee trauma - nerve - motor and sensory def
Gout
SERMs - calcitonin - bisphosphates or pulsatile PTH for severe cases
Tibial - foot inversioon and plantarflexion; toe flexion - sole of foot is sensory
Chondrosarcoma