Test your basic knowledge |

Musculoskeletal

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What do xray show in osteopetrosis and What do potential CN abnl result from
Basal cell carcinoma - pearly papules - commonly with telangiectasias
Radial - BEST extensors - posterior arm and dorsal hand/thumb - wrist drop
Erlenmeyer flask bones that flare out - narrowed foramina
Steroids

2. anaplastic small blue cell malignant tumor - most common in boys < 15 - dz and prognosis
Fibrinoid necrosis surrounded by palisading histiocytes
McCune - Albright syndrome
Peroneal everts and dorsiflexes - foot dropPED; tibial inverts and plantarflexes - can't stand on Tip toes
Ewings sarcoma - aggressive with early mets - but responsive to chemo

3. What kind of hypersens rxn is RA - and what serum marker is present in 80% of RA pts
Erythema nodosum
Urticaria
Wheal
Type III - RF

4. What do pseudogout crystals appear like microscopically
Basophilic - rhomboid crystals - weakly birefringent
Ephelis
Flat bone (skul - facial bones - axial skeleton) woven directly formed - no cartilage - later remodeled to lamellar
Chondrosarcoma

5. Decrease marrow space in osteopetrosis leads to what?
Cellulitis - s aureus - s pyogenes
Anemia - thrombocytopenia - infection - extramedullary hematopoiesis
After a large meal or EtOH conspumption
Renal - pulm - CV - GI - 75% female

6. How is chondrosarcoma described
Compressed by cervical rib or pancoasts tumor - leads to klumpke's
Ribonucleoprotein antigents - SS- A and SS- B (Ro and La)
MCL - ACL - lateral meniscus (esp in athletes)
Expansile glistening mass within the medullary cavity

7. What test if specific for lupus but doesn't indicate prognosis
Anti Smith
Lower trunk of brachial plexus
Endochondroma
Anti ds DNA - poor prognosis

8. In longitudinal bone growth - what model is made first (and By what cell) and What is it later replaced by (and By what cells) - process name
Muslce use - nerve stim/compound muscle test
Cartilaginous by chondrocytes first - osteoclasts and osteoblasts later replace with women bone and remodel to lamellar bone - endochondrial ossification
The dermis
Recurrent branch of the median nerve

9. What are the classic fractures in pts with osteoporosis

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

10. What is the landmark for an LP
Iliac crest
Anterior interosseous nerve
False positives on syphillis test (RPR/VRDL) due to antiphospholipid antibodies - cross react with cardiolipin
Median - lateral finger and wrist flexion - dorsal palmar aspects of lateral 3.5 fingers/thenar eminence - ape hand - carpal tunnel syndrome

11. What are the layers of of the epidermis from surface to base
Spindle shaped cells with multinucleated giant cells
Recurrent branch of the medain nerve
Interossei and adductor policis
Corneum - lucidum - granulosum - spinosum - basalis

12. In skeletal and smooth muscle contraction - when Ca2+ enters the cytoplasm - What does it do
Psoriasis
Binds troponin C causing a conformational change leading to tropomyosin to move out of the way allowing for actin/myosin cycling
Osteoporosis
Subclavius

13. What kind of jxn is in the zona adherens and Where is it - What is it composed of - and what ion does it does it depend on...
Intermediate jxn - just below zona occludens - cadherins and actin filaments - cadherins are dependent on Ca2+
Osteoarthritis
4th and 5th finger
ACH esterase inhibitors - edrophonium test - improvement of sx after edro means the patient is underdosed

14. which muscle type is fast twitch and why are fibers white
Vertebral crush fractures - femoral neck fractures - distal radius (Colles') fracture
Muslce use - nerve stim/compound muscle test
Type 2 - dec mitochondria and myoglobin - inc anaerobic glycolysis
Supraspinatus - infraspinatus - teres minor - subscapularis - SItS

15. irregular raised lesion resulting from scar tissue hypertrophy - follows trauma to skin - common to african americans see in T. pertenue (yaws)
Osteoarthritis
Hands and face - ulcerative red lesion - locally invasive bur rare metastasis - associated with chronic draining sinuses and keratin pearls
Keloid
Trauma

16. What does PED and Tip stand for

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

17. Anterior hip dislocation causes injury to what nerve and What are the motor and sensory defs
Voltage sens - dihydropiridine R coupled to ryanodine recpetor - conformational change in the SR - releasing Ca2+
EtOH metabolites compete for same excretion site in kidney as uric acid - causing dec uric acid secretion and subsequent buildup
Immunoglobulins - malar rash - discoid rash - ANA - mucositis (oropharyngeal ulcers) - neurologic disorders - serositis (pleuritis - pericarditis) - hematologic disorders - arthritis - renal - photosensitivity
Obturator - thigh adduction - medial thigh

18. inflammatory disorder affective synovial joints with pannus formation in joints
Radial nerve
Rheumatoid arthritis
Teres minor
Vit D def - dec Ca - inc PTH - dec serum phos - reversible when vit D is replaced

19. Which muscle laterally rotates and adducts arm
Teres minor
Age - obesity and joint deformity
Ligand binding leads to muscle depol
In psoriasis - bleeding spots when scales are scraped off

20. hyperpigmentation associated with pregnancy or OCP
Post GI infxn or chlamydia
Melasma (chloasma)
Loss of medial lumbrical fxn; 4th and 5th digits are clawed - when try to open hand - pinky and ring finger stay clawed
Inc Ca - dec phos - inc alk phos - inc PTH - brown tumors

21. interlacing trabeculae of woven bone surrounded by osteoblasts
Osteoid osteoma
Parakeratosis
Blow to the shoulder - trauma during delivery; limb hangs by side - medially rotated - forearm is pronated
Polymyaglia rheumatica associated with temporal (giant cell) arteritis

22. What is a precursor to squamous cell carcinoma
Osteoid osteoma
Actinic keratosis
Ankylosing spondylitis - uveitis - aortic regurg and bamboo spine
Mosiac bone pattern - long bone chalk stick fractures - increased hat size or hearing loss due to auditory foramen narrowing

23. What is the Auspitz sign
In psoriasis - bleeding spots when scales are scraped off
Ligand binding leads to muscle depol
Pustule
Erythema nodosum

24. Pain and stiffness in shoulders and hips - fever malaise and weight loss - no weakness - pts over 50 - associated with HA and jaw pain
Endochondroma
Polymyaglia rheumatica associated with temporal (giant cell) arteritis
Biceps
Stevens johnson syndrome - associated with adverse drug reactions - more severe version called toxic epidermal necrolysis

25. What associations go along with sarcoidosis

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

26. deep tissue injury - crepitus from methane and CO2 production 'flesh eating bacteria' - condition and orgs
Lung
Cellulitis - s aureus - s pyogenes
Seborrheic keratosis
Necrotizing fasciitis - anaerobic bacteria or S. pyogenes

27. What do lumbricals do
Flex the MCP joints and extend both the DIP and PIP joints
Inc spinosum - dec granulosum
Dermatomyositis
Immunoglobulins - malar rash - discoid rash - ANA - mucositis (oropharyngeal ulcers) - neurologic disorders - serositis (pleuritis - pericarditis) - hematologic disorders - arthritis - renal - photosensitivity

28. malignant cartilaginous tumor in men 30 to 60 - Name and common location
Binds myosin head and releases actin filament allowing cross - bridge cycling and shortening to occur
Wheal
Wire - loop lesions in kidney with immune complex deposition - death from renal failure and infxns
Chondrosarcoma - pelvis - spine - scapula - humerus - tibia - or femur

29. Where is C7 dermatome
Cervical disk lesion
3rd finger
Vitiligo - dec number in melanocytes
Parakeratosis

30. Where is T2 dermatome
Inc alk phos - abnl bone architecture
Axilla
Elevated 1 alpha hydroxylase mediated vit D activation in epithloid macrophages
Median nerve - same fingers but not on the hand

31. What are the histo findings in an osteoclastoma
Spindle shaped cells with multinucleated giant cells
Integrin binds laminin in BM
Medially rotates and adducts arm
Axillary nerve

32. What is CREST syndrome and What antibody is it associated with
Wheal
Calcinosis - raynauds - esophageal dysmotility - sclerodactyly - telangiectasia - anti centromere antibody
Paralysis of lateral rotators
Upper trunk compression - biceps - brachialis - corachobrachialis - flexion of arm at elbow - sensory = lateraly forearm

33. What is the TX for acute gout
Musculocutaneous
Seborrheic keratosis
Pemphigus vulgaris
NSAIDs (indomethacin) colchicine

34. What does the positive anterior drawer sign test indicate
Tear of the ACL
Immunoglobulins - malar rash - discoid rash - ANA - mucositis (oropharyngeal ulcers) - neurologic disorders - serositis (pleuritis - pericarditis) - hematologic disorders - arthritis - renal - photosensitivity
Flat bone (skul - facial bones - axial skeleton) woven directly formed - no cartilage - later remodeled to lamellar
Atopic dermatitis - eczema

35. progressive symmetric proximal muscle weakness cause by CD8+ T cell induced injury to myofibers - dz - most common area of involvement and pathgnomonic histological finding
Ulnar
Polymyositis - shoulders - perifasicular inflammation
Men - needle shaped and negatively birefringent = yellow crystals under parallel light
Type 1 - inc mitochondria and myoglobin conc - inc OXPHOS leading to sustained conctraction

36. What is the tumor marker for melanoma - who is at risk - what correlates with risk of metastasis and What is the gross path
Opposition of thumb - dorsal/palmar 3.5 fingers sensory - ulnar deviation upon wrist flexion
Tear of the ACL
Axilla
S100 - associated with sunligh exposure - fair skinned at risk - depth of tumor correlates with risk of mets - dark with irregular borders

37. Achondroplasia is a failure of what process which results in which characteristic findings
Failure of longitudinal growth (endochondrial ossification) leading to short limbs - membranous is unaffected - large head
Middle bicep down - cuts lateral at cuboidal foass and runs distally to include the thumb and 2nd digit
Inc spinosum - dec granulosum
Basophilic - rhomboid crystals - weakly birefringent

38. What percent of these mutations occur sporadically and what parental feature are they associated with
Papule
Melasma (chloasma)
Torn MCL
85% - advanced paternal age - or auto dominant inheritance

39. dried exudates from a vesicle - bulla or pustule seen impetigo
Crust
Pityriasis rosea
Melasma (chloasma)
Age - obesity and joint deformity

40. What nerve is compressed by supracondylar fracture of humerus
Median nerve
Median nerve - lunate bone
Condyloma acuminatum - caused by HPV
Outer arm

41. In which form is myosin light chain active
Boutonniere - swan neck - zthumb
ACH esterase inhibitors - edrophonium test - improvement of sx after edro means the patient is underdosed
Phosphorylated
Ulnar nerve

42. What antibody is less sensitive than RF but more specific and What is the HLA association
Polyostotic fibrous dysplasia
Acanthosis nigcricans
Phosphorylated
Anti - CCP - HLA- DR4

43. Flat discloration <1cm seen in tinea versicolor
Osteogenic carcinoma
Macule
Renal - pulm - CV - GI - 75% female
Mosiac bone pattern - long bone chalk stick fractures - increased hat size or hearing loss due to auditory foramen narrowing

44. What lesions causes Erb's palsy
Melasma (chloasma)
STD presents as a monarticular - migratory arthritis with an asynmetrical pattern - affected joint is painful - red and swollen
Serum ca - phos - PTH are nl alk phos elevated
Upper trunk of brachial plexus

45. fever - bulla formation and necrosis - sloughing of skin and high mortality - syndrome and associations
Stevens johnson syndrome - associated with adverse drug reactions - more severe version called toxic epidermal necrolysis
Pityriasis rosea
Axillary - deltoid - skin over deltoid - flattened deltoid
Medially rotates and adducts arm

46. What are the systemic symptoms found in RA
Actin
Lesion to lower trunk of brachial plexus - loss of fxn of all lumbricals - forearm finger flexors - finger extensors are unopposed (radial nerve)
NC migration
Fever - fatigue - pleuritis - pericarditis

47. inc thickness of stratum corneum seen in psoriasis
Voltage sens - dihydropiridine R coupled to ryanodine recpetor - conformational change in the SR - releasing Ca2+
Myosin
Hyperkeratosis
Morning stiffness for > 30 min improving with use - symmetry - systemic sx

48. hives - intensely pruritic wheals that form after mast cell degranulation
Glucocorticoids
Urticaria
Ulnar nerve
Pagets dz - bone infarcts - radiation - familial retinoblastoma - codman's triangle or sunburst pattern from elevation of periosteum - poor prognsosis

49. what changes are seen in stratum spinosum and granulosum in psoriasis
Inc spinosum - dec granulosum
Axilla
Lung
Female between 14 and 45 - mostly black

50. chronic inflammatory disease of sacroiliac joints and spine - dz - associations
Anti Smith
Ligand binding leads to muscle depol
Corneum - lucidum - granulosum - spinosum - basalis
Ankylosing spondylitis - uveitis - aortic regurg and bamboo spine