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Reproductive

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. What are causes of female pseudoHerm
Congenital adrenal hyperplasia - exogenous administration of steroids
Testosterone
Smooth muscle
Haploid - 2N - 23 sister chromatids

2. What causes preeclampsia
Placental ischemia due to impaired vasodltn of spiral arteries resulting in increased vasc tone
Proliferation
Brenner tumor
Granulosa cell tumor

3. is fibroadenoma a precursor to breast cancer
Lobular carcinoma - sclerosing adenosis
Yolk sac - endodermal sinus - tumor
No
Dysgerminoma

4. large cells in epidermis with clear halo
Paget cell
Asia - Africa - S. America - HPV - lack of circumcision
The ampulla - occurs within 1 day of ovulation
Fibroadenoma - phyllodes tumor

5. Multiple papular lesions on the penis - affects younger age group - usually does not become invasive
IV mag sulfate - diazepam
Bowenoid papulosis - carcinoma in situ of the penis
Low progesterone
Stimulation of secretion - but blocks its action at the breast

6. common cause of recurrent miscarriage in the 1st week
Male pseudoHerm
2 months
Low progesterone
1000 times

7. endometrium within the myometrium
GnRH from hypoTh - LH and FSH from ant pituitary
Left gonadal vein - left renal vein - IVC
Adenomyosis
Estradiol

8. Uterin fundus to labia majora
Left
Decreasing progesterone
Follicular phase varies - luteal phase is 14
Round ligament of uterus

9. How many days after fertilization does implantation occur?
Placenta previa
Relaxation
6
Mucinous cystadenocarcinoma

10. Which androgen is responsible for the closing of the epiphyseal plate
DRE - hard nodule and biopsy
Whorled pattern of smooth muscle bundles
Testosterone
Paget cell

11. Connects ovary to lateral uterus
1000 times
Peripheral conversion of androgens
Prior c section - multiparity
Ligament of the ovary

12. What is the most common gynecologic malignancy
Congenital adrenal hyperplasia - exogenous administration of steroids
Diploid - 4N - 46 sister chromatids
Complete
Endometrial carcinoma

13. How many functional sperm does 1 germ cell creat?
DHT - testosterone - androstenedione
In the 6th decade of life
Production of a thick cervical mucus
4

14. Is fertility compromised in double Y males?
Tunica vaginalis lesions
No
Whorled pattern of smooth muscle bundles
Yolk sac - endodermal sinus - tumor

15. What percentage of testicular tumors are germ cell
Seminiferous tubules - epididymis - vas deferens - ejaculatory ducts - nothing - urethra - penis
Chromosomal abnormalities
Leydig cell tumor
95%

16. What does progesterone do to gonadotropins
Post menopausal
Androgen insensitivity syndrome - 46 XY
Decrease
Inhibition LH and FSH

17. decreased synthesis of gonadotropin in the ant pit - anosmia - lack of secondary sex characteristics
Chromosomal abnormalities
Hyperestrogenism
Kallman
Increase (and LH)

18. What is a true hermaphrodite
CIN 1 - 2 - 3
Both ovary and testicular tissue present - ambiguous genitals - rare 46 XX - 47XXY
Round ligament of uterus
Brenner tumor

19. When does the secondary oocyte complete meosis II

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20. 50% of ovarian tumors - malignant and frequently bilateral
Serous cystadenocarcinoma
Visceral - somatic nerves in pudendal
Unopposed estrogen - obesity - diabetes - HTN - nulliparity - late menopause
Cervix

21. Breast path - disease that occurs at the nipple

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22. Which androgen is responsible for libido
Testosterone
Good - late metastasis
Maintenance
Uterus

23. What serum markers are associated with embyronal carcinoma
Inc AFP and hCG
Posterior lobe peripheral zone
Follicular phase varies - luteal phase is 14
Leydig cell tumor

24. What is the genetic material in the secondary oocyte?
Haploid - 2N - 23 sister chromatids
Right gonadal vein - IVC
Spermatogonia (germ cells)
Defective androgen receptor

25. dx with decreased testosterone and decreased LH
Broad ligament
Serous cystadenocarcinoma
Fertilization 'an egg met a sperm'
Hypogondadotropic hypogonadism

26. What is the lymphatic drainage the ovaries/testis
Call exner bodies
Lateral invasion can block ureters causing renal failure
Weight loss - OCP - gonadotropin analogs - clomiphene - sprinolactone - surgery
Para - aortic lymph nodes

27. What is the right venous drainage of the ovary/testis
Right gonadal vein - IVC
Aortic bicuspid valve
Cirrhosis - testicular tumor - puberty - old age - klinefelter's syndrome - drugs
Left gonadal vein - left renal vein - IVC

28. What metastasis is most common with prostatic adenocarcinoma
Inhibit cGMP breakdown
Osteoblastic in bone
Delivery of fetus
Testosterone secreting tumor - exogenous steroids

29. what metabolic disorder is assocaited with PCOS
Insulin resistance
5 alpha reductase - inhibited by finesteride
Primary hypogonadism
Prior c section - inflammation - placenta previa

30. breast path - diseases of the stroma
Fibroadenoma - phyllodes tumor
Abacterial
Metaphase
Adenomyosis

31. What is the treatment for preeclampsia
Delivery of fetus
2 months
Corpus luteum - placenta - adrenal cortex - testes
Inflammatory

32. androblastoma from sex cord stroma
Serous cystadenocarcinoma
69 xxy
Sertoli cell tumor
Slight increase - 1.5 to 2

33. What are the treatments for PCOS
46 xx
Sprinolactone - digitalis - cimetidine - alchohol - ketoconazole
Weight loss - OCP - gonadotropin analogs - clomiphene - sprinolactone - surgery
Theca cell - desmolase - androstenedione

34. What is the most common cause of breast lumps from age 25 to menopause
4
Sertoli cells - and adipose tissue via aromatase
Choriocarcinoma
Fibrocystic disease

35. Red velvety plaques - usually involving the glans - similar to Bowen's
Increase (and LH)
Post menopausal bleeding
Erythroplasia of Queyrat - carcinoma in situ of penis
Invasive lobular

36. What does estrogen stimulate in the endometrium
Proliferation
Estradiol and possible growth promoting effects of DHT
Choriocarcinoma
Choriocarcinoma

37. What is the clinical manifestation of PCOS
Golgi
Enlarged bilateral cystic ovaries - amenorrhea - infertility - obesity - and hirsutism
Haploid - N - 23 single chromatids
20 to 40

38. What is DHT responsible for in late development
Milk letdown - uterine contractions?
Kallman
Prostate growth - balding - and sebaceous gland activity
Para - aortic lymph nodes

39. What are the 3 androgens
Testosterone - DHT - androstenedione
Low back pain with increased serum alk phos
Mucinous cystadenoma
Testosterone

40. increases in which hormone are associated with BPH
Severe bleeding iron def anemia - miscarriage
Periurethral lobes - lateral and middle
Estradiol and possible growth promoting effects of DHT
Dilation and curettage and methotrexate

41. What is a complication of cryptorchidism and why does it occur
Dysuria - frequency - urgency - low back pain
Lack of spermatogenesis due to inc temp of testis inside body and associated risk of germ cell tumors
Estradiol
Inhibition LH and FSH

42. histological subtype of fibrocystic with inc number of epithelial cell lauers in terminal duct lobule - women over 30
Proliferation
Granulosa cell tumor
Embryonal carcinoma
Epithelial hyperplasia

43. Which system and nerve allow for erection in the male?
The semiT and the blood vessels
Bowen's dz - carcinoma in situ of the penis
Smoking - HTN - cocaine
PANS - pelvic nerve

44. in males - are mature teratomas malignant? What is the case for females
Tight junctions between sertoli cells
Differentiation of penis - scrotum and prostate
Malignant in males not in females
Induces and maintains lactation - decreases reproductive function

45. HTN - proteinuria and edema
Post menopausal bleeding
The anterior pituitary and hypothalamus
Spermatocele
Preeclampsia

46. What does FSH do
Klinefelter's - XXY
Hydrocele
Stimulates sertoli cells to produce ABP and inhibin
Prior c section - inflammation - placenta previa

47. when do primary oocytes begin meiosis I
Increase in size in pregs - decrease in size meno - estrogen sens
Ectopic preg
Bowenoid papulosis - carcinoma in situ of the penis
During fetal life

48. What changes in the aorta are common in Turner's?
Aortic bicuspid valve
Endometrial carcinoma
Prostate growth - balding - and sebaceous gland activity
Preductal coarctication

49. What is the flaggelum derived from
One of the centrioles
Small infiltrating glands with prominent nucleoli
Increase in size in pregs - decrease in size meno - estrogen sens
Stimulate glandular secretions - and spiral artery development

50. What is the lymphatic drainage of the distal 1/3 of the vagina/scrotum/vulva
Suspensory ligament of ovaries
DIC
Metaphase
Superficial inguinal lymph nodes