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Reproductive

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. What is the risk for carcinoma among patients with intraductal papilloma
Slight increase - 1.5 to 2
55-65
Inc size and tenderness with inc estrogen
Post menopausal

2. What does FSH do
Develop both male and female internal genitalia and male external genitalia
Oligomenorrhea
Stimulates sertoli cells to produce ABP and inhibin
In the 6th decade of life

3. What is the treatment for hydatidiform mole
Dilation and curettage and methotrexate
1000 times
Hemolysis - elevated liver enzymes - low platelets
Suckling - inc oxytocin - prolactin

4. Is fertility compromised in double Y males?
Follicular phase varies - luteal phase is 14
Tubular carcinoma
4
No

5. when do primary oocytes begin meiosis I
Mittelschmerz syndrome
Choriocarcinoma
Klinefelter's - XXY
During fetal life

6. breast path - diseases of the major duct
Fibrcystic change - ductal cancer
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility
Sertoli cell tumor
Relaxation

7. 2 sperm + empty egg
Development of genitalia and breast - growth of follicle - hormonal interactions with HPG accesss - and inc transport proteins like SHBG inc HDL and dec LDL
Cerebral hemorrhage and ARDS
Immature
Complete

8. hyperandrogenism due to deranged steroid synthesis by theca cells - inc LH leading to anovulation
PCOS
The ampulla - occurs within 1 day of ovulation
Fat necrosis
Distention and hypertrophy of bladder - hydronephrosis - UTIs - not premalignant

9. When is follicular growth the fastest?
GnRH from hypoTh - LH and FSH from ant pituitary
2nd week of proliferative phase
Lobular carcinoma - sclerosing adenosis
Testosterone - DHT - androstenedione

10. Endometriosis is characterized By what clinical picture?
Theca cell - desmolase - androstenedione
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility
Call exner bodies
Osteoblastic in bone

11. When does the secondary oocyte complete meosis II

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12. What does progesterone do to smooth muscle in the uterus
S aureus
Fibroadenoma
2 months
Relaxation

13. How long does it take for sperm to fully develop
Primary hypogonadism
Suspensory ligament of ovaries
2 months
Abruptio placentae

14. vaginal carcinoma affecting girls < 4 spindle shaped tumors cells that are desmin positive
Fibrosis
Placental insufficiency - bilateral renal agenesis - posterior urethral valves - potter's syndrome
Placenta acreta
Sarcoma botryoides - a rhabdomyosarcoma variant

15. What is the source of estrogen after menopause
Menometrorrhagia
The ampulla - occurs within 1 day of ovulation
Peripheral conversion of androgens
Corpus luteum cyst

16. defect in androgen receptor resulting in normal appearing female - rudimentry vagina - no uterus or uterine tubes
Upregulation - LH surge - ovulation
Corpus luteum cyst
Round ligament of uterus
Androgen insensitivity syndrome - 46 XY

17. What is the most common form of male pseudoHerm
Androgen insensitivity syndrome
Estrogen - LH surge - ovulation - progesterone from CL - menstruation
Final stage of spermatogenesis - spermiogenesis - spermatid to spermatozoa
2 months

18. In what group are malignant breast tumors most commonly seen
Andogren binding protein - anti mullerian hormone
Post menopausal
Immature
DIC

19. tumor that fills ductal lumen - arises from ductal hyperplasia - early malignancy without BM penetration
DCIS
Ovarian > cervical > endometrial
Mitochondria
Sertoli cells

20. predisposing factor to clear cell adenocarcinoma of the vagina
Vagina
Esophogeal/duodenal atresia - can't swallow - anencephaly
Testosterone secreting tumor - exogenous steroids
DES in utero (DES is a sythetic estrogen)

21. What effect does NO have on smooth muscle in erectile tissues
Inc cGMP - smooth muscle relax - vasodltn - proerectile
Prostatic acid phosphatase and PSA
Androgen insensitivity syndrome - 46 XY
Klinefelter's - XXY

22. Which system and nerve allow for erection in the male?
No
Testosterone - DHT - androstenedione
GnRH from hypoTh - LH and FSH from ant pituitary
PANS - pelvic nerve

23. What does the SRY gene do
DES in utero (DES is a sythetic estrogen)
Testis determining factor
Smooth muscle
50 times

24. histo: simple columnar epithelium
Endocervix
Develop both male and female internal genitalia and male external genitalia
Andogren binding protein - anti mullerian hormone
Dysuria - frequency - urgency - low back pain

25. leiomyoma and leiosarcoma have an increased incidence in which ethnic group
Decrease
Invasive ductal
Ovarian > cervical > endometrial
Blacks

26. What does the tail go onto to form
2nd week of proliferative phase
The centrioles
Endometrial carcinoma
Invasive lobular

27. What is a complication of invasive carcinoma
5 alpha reductase - inhibited by finesteride
Bicornute uterus
46 xx
Lateral invasion can block ureters causing renal failure

28. small - mobile - firm breast mass with sharp edges - most common in <25
Hyperthyroidism - contains functional thyroid tissue
In the 6th decade of life
Fibroadenoma
Ovary

29. Which androgen is responsible for differentiation of epididymis - vas deferens - seminal vesicles - internal genitalia (except prostate)
Testosterone
Metrorrhagia
Low back pain with increased serum alk phos
Uterus

30. which cysts results from gonadotropin stimulation and is associated with choriocarcinoma and moles
Down regulation
Cervix
Theca - leutin cysts
Estradiol

31. List the estrogens in order of decreasing potency
Estradiol > estrone > estriol
17beta estradiol
Polyhydramnios
Menopause

32. Connects uterus - fallopian tubes and ovaries to pelvic side wall - contains ovaries - fallapian tubes - and round ligaments of uterus
Hypogondadotropic hypogonadism
Broad ligament
Immature
Induces and maintains lactation - decreases reproductive function

33. What does SEVEN Up stand for in regards to the pathway of sperm
Inc risk for carcinoma
Fibromas
Seminiferous tubules - epididymis - vas deferens - ejaculatory ducts - nothing - urethra - penis
Hirsutism - hot flashes - atrophy of the vagina - osteoporosis - coronary artery disease

34. How does exogenous testosterone create azoospermia
Follicular cyst
Inhibition of HCG access
Abacterial
Round ligament of the uterus

35. bundles of spindle shaped fibroblasts - pulling sensation in the groin
Final stage of spermatogenesis - spermiogenesis - spermatid to spermatozoa
Fibromas
Smoking - HTN - cocaine
Adenomyosis

36. Uterin fundus to labia majora
Inc in total - and dec in free fraction
Testosterone
Prophase
Round ligament of uterus

37. dx with increased testosterone and inc LH
Defective androgen receptor
Adrenal gland
Sertoli cells
Seminoma

38. gray - soliarty - crusty plaque - usually on the shaft of the penis or on the scrotum - peak incidence in 5th decade of life - can progress to invasive SCC in < 10% of cases

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39. blood containing cyst from ovarian endometriosis that varies with menstrual cycle
Chocolate cyst
Myometrial tumors
20 to 40
Mammary duct epithelium or lobular glands

40. What is the typical cell change in HPV infection
Granulosa cell tumor
Estradiol > estrone > estriol
Koilocytitic
Increase in size in pregs - decrease in size meno - estrogen sens

41. What is the lymphatic drainage the ovaries/testis
Slight increase - 1.5 to 2
Para - aortic lymph nodes
Inflammatory
Inc estrogen - inc total nunmber of cycles - older age at 1st live birth - obesity

42. When are phyllodes tumors most common
Choriocarcinoma
Polymenorrhea
Inflammatory
In the 6th decade of life

43. What is the serum marker for BPH
Fibroadenoma
PSA
1000 times
Estradiol and possible growth promoting effects of DHT

44. What are the functions of oxytocin - maybe
Fat necrosis
Hypogondadotropic hypogonadism
IV mag sulfate - diazepam
Milk letdown - uterine contractions?

45. What percentage of testicular tumors are germ cell
95%
Endometrial carcinoma
Comedocarcinoma
Serous cystadenoma

46. How many days after fertilization does implantation occur?
Prior c section - multiparity
Fibrosis
6
Retrograde mentrual flow or ascending infection

47. What effect does NE have on smoothe muscle in the erectile tissues
Peyronie's dz
Seminoma
Inc Ca in - smooth muscle contraction - vasocxn - antierectile
Fibromas

48. What does progesterone do to gonadotropins
Follicular cyst
Inhibition LH and FSH
Mature teratoma
Serous cystadenocarcinoma

49. malignancy in ovaries - testis - sacrococcygeal area of young children - yellow friable solid masses with 50% having schiller - duval bodies
Yolk sace - endodermal sinus - tumor
Malignant in males not in females
Sclerosing adenosis
Intraductal papilloma - breast abscess - mastitis

50. how can struma ovarri present?
Relaxation
Mucinous cystadenoma
Oligohydramnios
Hyperthyroidism - contains functional thyroid tissue