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Reproductive

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. tumor is ductal with caseous necrosis
GnRH from hypoTh - LH and FSH from ant pituitary
Comedocarcinoma
Mucinous cystadenocarcinoma
Increase (and LH)

2. What pathologic states cause increases in hCG
Follicular phase varies - luteal phase is 14
Mucinous cystadenoma
Hydatidiform moles - choriocarcinoma - gestational trophoblastic tumors
Corpus luteum - placenta - adrenal cortex - testes

3. leiomyoma and leiosarcoma have an increased incidence in which ethnic group
Blacks
Corpus luteum cyst
PSA
Mammary duct epithelium or lobular glands

4. Short stature - ovarian dysgenesis - shield chest - no barr body - webbing of the neck

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5. endometrium within the myometrium
Adenomyosis
Hydrocele
Pseudohermaphroditism
Mucinous cystadenoma

6. When does the secondary oocyte complete meosis II

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7. What is DHT responsible for in early development?
Hyperestrogenism
Teratoma
Differentiation of penis - scrotum and prostate
Cervix

8. What are the 4 sources of progesterone
Squamous cell carcinoma
Severe bleeding iron def anemia - miscarriage
2nd week of proliferative phase
Corpus luteum - placenta - adrenal cortex - testes

9. Where does FSH work - what enzyme works there - what substrate comes in and what leaves
Cervix
Klinefelter's - XXY
Granulosa cell - aromatase - androstenedione - estrogen
Unopposed estrogen - obesity - diabetes - HTN - nulliparity - late menopause

10. What happens to a leiomyoma in pregs and menopause and why
Estradiol
Increase in size in pregs - decrease in size meno - estrogen sens
Male pseudoHerm
Mitochondria

11. can present as precocious puberty in kids - can cause endometrial hyperplasia/carinoma in adults - abnormal uterine bleeding
Periurethral lobes - lateral and middle
Granulosa cell tumor
Prementsrual breast pain and multiple lesions
Inc estrogen - inc total nunmber of cycles - older age at 1st live birth - obesity

12. tumor with firm fibrous - 'rock hard' mass with sharp margins and small glandular duct like cells - worst prognosis and most common
Prior c section - multiparity
Paget cell
Cystic
Invasive ductal

13. Where does LH work - what enzyme works there and what product is secreted
Fibrocystic disease
Puberty
Theca cell - desmolase - androstenedione
Tubular carcinoma

14. Where is SCC of the penis more common and What is it associated with
Right gonadal vein - IVC
Asia - Africa - S. America - HPV - lack of circumcision
Inc size and tenderness with inc estrogen
Axillary node involvement

15. What estrogen does the placenta secrete
Endometrial carcinoma
Estradiol
BPH
Seminiferous tubules - epididymis - vas deferens - ejaculatory ducts - nothing - urethra - penis

16. premature detachment of placenta from implantation site leading to fetal death
GnRH from hypoTh - LH and FSH from ant pituitary
Hyperestrogenism
Complete
Abruptio placentae

17. What increase in estriol is an indicator offetal well being in pregnancy
1000 times
Testosterone
Mucinous cystadenoma
The anterior pituitary and hypothalamus

18. What does progesterone do in the endometrium
Acute mastitis
The ampulla - occurs within 1 day of ovulation
Stimulate glandular secretions - and spiral artery development
Serous cystadenocarcinoma

19. defective decidual later allows placenta to attach to myometrium - massive bleeding after delivery
Production of a thick cervical mucus
1000 times
Placenta acreta
SANS - hypogastric nerve

20. What is the right venous drainage of the ovary/testis
Ligament of the ovary
Stimulates sertoli cells to produce ABP and inhibin
Right gonadal vein - IVC
Inhibition LH and FSH

21. What virus is dyslapsia and carcinoma in situ of the cervix associated with
Peripheral adipose tissue
HPV 16 - 18
Intraductal papilloma
The semiT and the blood vessels

22. What is the expected increase of estradiol and estrone in pregnancy
50 times
Inhibit FSH
Mitochondria
BPH

23. decreased estrogen - inc FSH - LH - signs of menopause after puberty but before 40
Anovulatory cycles - hormone replacement therapy - PCOS - granulosa cell tumor
Premature ovarian failure (Pof)
Comedocarcinoma
Round ligament of the uterus

24. How does exogenous testosterone create azoospermia
Puberty
DES in utero (DES is a sythetic estrogen)
Inhibition of HCG access
Testis determining factor

25. What metastasis is most common with prostatic adenocarcinoma
Endometrial carcinoma
Inc risk for carcinoma
Osteoblastic in bone
Krukenburg tumor

26. When are phyllodes tumors most common
In the 6th decade of life
Peripheral conversion of androgens
PCOS
Delivery of fetus

27. decreased estrogen production due to age linked decline in the number of ovarian follices
Cirrhosis - testicular tumor - puberty - old age - klinefelter's syndrome - drugs
Menopause
Peyronie's dz
Small infiltrating glands with prominent nucleoli

28. multilocular cyst lined by mucus secreting epi - benign - intestine like
Vagina
The semiT and the blood vessels
Lateral invasion can block ureters causing renal failure
Mucinous cystadenoma

29. What is the clinical manifestation of PCOS
Enlarged bilateral cystic ovaries - amenorrhea - infertility - obesity - and hirsutism
Osteoblastic in bone
Bicornute uterus
Pseudohermaphroditism

30. What does estrogen stimulate in the endometrium
Insulin resistance
DRE - hard nodule and biopsy
Proliferation
Preeclampsia

31. cystic swelling of chorionic villi and proliferation of chorionic epithelium that presents with abnormal vaginal bleeding
Female pseudoHerm
Mitochondria
Post menopausal bleeding
Hydatidiform mole

32. breast path - diseases of the stroma
Maintenance
Androgen insensitivity syndrome
Fibroadenoma - phyllodes tumor
Sclerosing adenosis

33. complications of BPH
BPH
Cerebral hemorrhage and ARDS
Down regulation
Distention and hypertrophy of bladder - hydronephrosis - UTIs - not premalignant

34. dx with decreased testosterone - increased LH
Phyllodes tumor
Primary hypogonadism
Metaphase
Low progesterone

35. What does increasing estrogen do to GnRH receptors on ant pit - and What does this lead to...
Upregulation - LH surge - ovulation
Severe bleeding iron def anemia - miscarriage
Superficial inguinal lymph nodes
Endometrial carcinoma

36. What does inhibin do?
Relaxation
Inhibit FSH
Milk letdown - uterine contractions?
Leydig cell tumor

37. Where is testosterone secreted into?
The semiT and the blood vessels
History of infertility - salpingitis - ruptured appendix - prior tubal surgery
Cystic
Acute mastitis

38. What is the treatment for preeclampsia
Hydatidiform mole
Fertilization 'an egg met a sperm'
50 times
Delivery of fetus

39. 90% of ovarian germ cells tumors - contains cells from 2 or 3 germ layers
Teratoma
Testosterone
Menometrorrhagia
Adolescents

40. histo: stratified squamous epithelium - nonkeratinized
Estradiol > estrone > estriol
Vagina
Induces and maintains lactation - decreases reproductive function
SANS - hypogastric nerve

41. What are the treatments for PCOS
Weight loss - OCP - gonadotropin analogs - clomiphene - sprinolactone - surgery
Decrease
Fallopian tube
Menometrorrhagia

42. What is the lymphatic drainage the ovaries/testis
Fibrocystic disease
One of the centrioles
Para - aortic lymph nodes
PCOS - obesity - Asherman's - HPO axis defect - Pof - hyperprolactinemia - thryoid - eating disorders - cushging's - adrenal insuff

43. Which androgen is responsible for the closing of the epiphyseal plate
Testosterone
Lateral invasion can block ureters causing renal failure
PCOS - obesity - Asherman's - HPO axis defect - Pof - hyperprolactinemia - thryoid - eating disorders - cushging's - adrenal insuff
Lobular carcinoma - sclerosing adenosis

44. what usually causes endometrial hyperplasia
Estrogen overstimulation
Axillary node involvement
Invasive lobular
6

45. Is fertility compromised in double Y males?
No
The centrioles
Squamo - columnar jxn
Inhibition of HCG access

46. What does estrogen do to FSH and LH
Puberty
Hydrocele
Unopposed estrogen - obesity - diabetes - HTN - nulliparity - late menopause
Feedback inhibition

47. what increases the risk of cryptorchidism
Corpus luteum - placenta - adrenal cortex - testes
Hirsutism - hot flashes - atrophy of the vagina - osteoporosis - coronary artery disease
Prematurity
Increased FSH

48. What does estrogen do to estrogen - LH and progesterone recepotrs
Upregulation
Hyperestrogenism
Chromosomal abnormalities
No

49. Red velvety plaques - usually involving the glans - similar to Bowen's
Inhibition of HCG access
Suspensory ligament of ovaries
50 times
Erythroplasia of Queyrat - carcinoma in situ of penis

50. What does progesterone do for pregnancy
Maintenance
Left gonadal vein - left renal vein - IVC
Sarcoma botryoides - a rhabdomyosarcoma variant
Seminoma