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Reproductive

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Answer 50 questions in 15 minutes.
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1. headache - blurred vision - abdominal pain - edema of face and extremeties - altered mentation - hyperreflexia in pregnancy
Tubular carcinoma
DRE - hard nodule and biopsy
Preeclampsia clinical
Yolk sace - endodermal sinus - tumor

2. disagreement between the phenotypic and gonadal sex
Prophase
Varicocele
Pseudohermaphroditism
Left gonadal vein - left renal vein - IVC

3. What is the common presentation of metastasis in prostate cancer
Ovary
Severe bleeding iron def anemia - miscarriage
Low back pain with increased serum alk phos
PCOS - obesity - Asherman's - HPO axis defect - Pof - hyperprolactinemia - thryoid - eating disorders - cushging's - adrenal insuff

4. histological subtype of fibrocystic with inc number of epithelial cell lauers in terminal duct lobule - women over 30
Sprinolactone - digitalis - cimetidine - alchohol - ketoconazole
Epithelial hyperplasia
17beta estradiol
Estrogen overstimulation

5. inability to convert testosterone to DHT - limited to genetic males - penis at 12
5 alpha reductase def
Epithelial hyperplasia
Hemorrhage
Mucinous cystadenocarcinoma

6. What pathologic states cause increases in hCG
Induces and maintains lactation - decreases reproductive function
Hydatidiform moles - choriocarcinoma - gestational trophoblastic tumors
Myometrial tumors
Seminiferous tubules - epididymis - vas deferens - ejaculatory ducts - nothing - urethra - penis

7. testes present with non male external genitals
Menometrorrhagia
Male pseudoHerm
Bowenoid papulosis - carcinoma in situ of the penis
Mitochondria

8. What does progesterone do in the endometrium
6
Asia - Africa - S. America - HPV - lack of circumcision
Insulin resistance
Stimulate glandular secretions - and spiral artery development

9. 2 sperm + empty egg
Multiple sexual partners - also HIV and early sexual intercourse
Placental insufficiency - bilateral renal agenesis - posterior urethral valves - potter's syndrome
Krukenburg tumor
Complete

10. tumor with orderly row of cells - often multiple and bilateral
Invasive lobular
In the 6th decade of life
Corpus luteum - placenta - adrenal cortex - testes
The ampulla - occurs within 1 day of ovulation

11. Short stature - ovarian dysgenesis - shield chest - no barr body - webbing of the neck

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12. What does increasing estrogen do to GnRH receptors on ant pit - and What does this lead to...
Primary hypogonadism
Esophogeal/duodenal atresia - can't swallow - anencephaly
Anovulatory cycles - hormone replacement therapy - PCOS - granulosa cell tumor
Upregulation - LH surge - ovulation

13. What is the expected increase of estradiol and estrone in pregnancy
Puberty
Inhibit FSH
50 times
Vagina

14. non neoplastic endometrial glands/stroma in abnormal locations outsdie the uterus
Call exner bodies
Choriocarcinoma
Endometriosis
Inhibit FSH

15. What are the most common tumors in all females?
Serous cystadenoma
Estrogen overstimulation
Inhibition LH and FSH
Myometrial tumors

16. dx with increased testosterone and inc LH
Defective androgen receptor
69 xxy
Post menopausal
Testicular lymphoma

17. cystic swelling of chorionic villi and proliferation of chorionic epithelium that presents with abnormal vaginal bleeding
Serous cystadenocarcinoma
The anterior pituitary and hypothalamus
Adolescents
Hydatidiform mole

18. histo: stratified squamous epithelium - nonkeratinized
Inhibition LH and FSH
Vagina
Estrogen/progesterone receptors - erb - B2 - HER2 an EGF receptrs
Menopause

19. Which cells line the seminiferous tubules and secrete inhibin
Fibroadenoma - phyllodes tumor
Sertoli cells
Aortic bicuspid valve
Adenomyosis

20. predisposing factor to clear cell adenocarcinoma of the vagina
Peripheral adipose tissue
Inc AFP and hCG
Androgen insensitivity syndrome
DES in utero (DES is a sythetic estrogen)

21. When is the peak occurrence of leiomyoma
20 to 40
Oligomenorrhea
Maintenance
55-65

22. What forms the blood testis barrier?
Tight junctions between sertoli cells
Abacterial
Ligament of the ovary
Serous cystadenocarcinoma

23. Which hydatidiform mole has the greater risk for malignancy
Complete
Mucinous cystadenoma
Inhibit cGMP breakdown
Inc freq of urination - nocturia - difficulty starting/stopping urination - dysuria

24. What is the most common pathogen in acute mastitis
95%
S aureus
DCIS
Decrease

25. What does inhibin do?
Testosterone
Low back pain with increased serum alk phos
Inhibit FSH
Proliferation

26. 90% of ovarian germ cells tumors - contains cells from 2 or 3 germ layers
Lobular carcinoma - sclerosing adenosis
Medullary
Teratoma
Prior c section - multiparity

27. GI malignancy that metastasizes to ovaries causing a mucin secreting signet cell adenocarcinoma
Multiple sexual partners - also HIV and early sexual intercourse
Krukenburg tumor
Develop both male and female internal genitalia and male external genitalia
Sclerosing adenosis

28. What cellular structure is the acrosome derived from?
20 to 40
Oligomenorrhea
Golgi
The semiT and the blood vessels

29. What serum markers are associated with embyronal carcinoma
Feedback inhibition
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility
Inc AFP and hCG
17beta estradiol

30. What is the typical cell change in HPV infection
Koilocytitic
Peripheral adipose tissue
Krukenburg tumor
Premature ovarian failure (Pof)

31. marked increased hCG - complete or partial
Complete
No
Bicornute uterus
4

32. Testosterone and estrogen in androgen insensitivity syndrome
Increase (and LH)
Serous cystadenoma
Serous cystadenocarcinoma
Dysgerminoma

33. breast path - diseases of the major duct
Fibrcystic change - ductal cancer
Endometriosis
Male pseudoHerm
Preeclampsia clinical

34. Some drugs cause awesome knockers
Menopause
Sprinolactone - digitalis - cimetidine - alchohol - ketoconazole
Choriocarcinoma
Para - aortic lymph nodes

35. dilated vein in pampiniform plexus - bag of worms
Varicocele
Premature ovarian failure (Pof)
Fibroadenoma
Teratoma

36. What is DHT responsible for in late development
Adrenal gland
Mitochondria
Hemorrhage
Prostate growth - balding - and sebaceous gland activity

37. A leimyoma is overgrowth of what cell
Smooth muscle
Uterus
Anovulatory cycles - hormone replacement therapy - PCOS - granulosa cell tumor
Low back pain with increased serum alk phos

38. Why does the skin resemble an orange peel in inflammatory type of maligantn breast tumor
Endometriosis
Neoplastic cells block lymphatic drainage
Mittelschmerz syndrome
CIN 1 - 2 - 3

39. is fibroadenoma a precursor to breast cancer
Fertilization 'an egg met a sperm'
Aortic bicuspid valve
No
Peyronie's dz

40. malignant - inc hCG - disordered syncytiotrophoblastic and cytotrophoblastic elements - hematogenous spread
Low back pain with increased serum alk phos
Mature teratoma
Down regulation
Choriocarcinoma

41. what metabolic disorder is assocaited with PCOS
Male pseudoHerm
Prostatic acid phosphatase and PSA
Granulosa cell - aromatase - androstenedione - estrogen
Insulin resistance

42. What is the number 1 risk factor for cervical dysplasia or carcinoma in situ
Multiple sexual partners - also HIV and early sexual intercourse
Preeclampsia + siezures
Epithelial hyperplasia
Corpus luteum - placenta - adrenal cortex - testes

43. Between What two phases does the sperm acquire the acrosome - flagellum - and middle piece
The semiT and the blood vessels
Final stage of spermatogenesis - spermiogenesis - spermatid to spermatozoa
In the 6th decade of life
Androgen insensitivity syndrome

44. What is the karyotype of a partial mole
Develop both male and female internal genitalia and male external genitalia
Development of genitalia and breast - growth of follicle - hormonal interactions with HPG accesss - and inc transport proteins like SHBG inc HDL and dec LDL
69 xxy
Necrosis - hemorrhage - can protrude from the cervix and bleed - tendency to recur

45. Where is testosterone converted to estrogen
Dysuria - frequency - urgency - low back pain
Hirsutism - hot flashes - atrophy of the vagina - osteoporosis - coronary artery disease
Sertoli cells - and adipose tissue via aromatase
Inhibition of HCG access

46. What is HELLP syndrome
Endocervix
Hemolysis - elevated liver enzymes - low platelets
Estrogen - LH surge - ovulation - progesterone from CL - menstruation
Low back pain with increased serum alk phos

47. What is the order of events in the menstrual cycle
Testosterone - DHT - androstenedione
Mittelschmerz syndrome
Estrogen - LH surge - ovulation - progesterone from CL - menstruation
Mucinous cystadenoma

48. HTN - proteinuria and edema
Preeclampsia
Prementsrual breast pain and multiple lesions
Andogren binding protein - anti mullerian hormone
Inhibition of HCG access

49. What are predisposing factors for placenta previa
Round ligament of uterus
Prior c section - multiparity
1000 times
Distention and hypertrophy of bladder - hydronephrosis - UTIs - not premalignant

50. histologic type of fibrocystic with fluid filled - blue dome and ductal dilation
Choriocarcinoma
17beta estradiol
Weight loss - OCP - gonadotropin analogs - clomiphene - sprinolactone - surgery
Cystic

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Reproductive

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