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Reproductive

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. Which cells line the seminiferous tubules and maintain germ pool and produce primary spermatocytes
Post menopausal
Fertilization 'an egg met a sperm'
Testosterone
Spermatogonia (germ cells)

2. What are the useful tumor parkers in prostatic adenocarcinoma
Peripheral adipose tissue
Prostatic acid phosphatase and PSA
Retrograde mentrual flow or ascending infection
DHT - testosterone - androstenedione

3. What is the typical cell change in HPV infection
Sclerosing adenosis
Koilocytitic
IV mag sulfate - diazepam
Necrosis - hemorrhage - can protrude from the cervix and bleed - tendency to recur

4. >1.5 -2 L of amniotic fluid
Polyhydramnios
Periurethral lobes - lateral and middle
Call exner bodies
IV mag sulfate - diazepam

5. small breast tumor that grows in lactiferous ducts - typically beneath the areola with serous or bloody nipple discharge
Prostate growth - balding - and sebaceous gland activity
Testicular lymphoma
Intraductal papilloma
Androgen insensitivity syndrome

6. What are the effects of prolactin?
Invasive lobular
Serous cystadenoma
Axillary node involvement
Induces and maintains lactation - decreases reproductive function

7. What is the prognosis for seminoma
Develop both male and female internal genitalia and male external genitalia
Inc freq of urination - nocturia - difficulty starting/stopping urination - dysuria
Good - late metastasis
Endometrial carcinoma

8. tumor that fills ductal lumen - arises from ductal hyperplasia - early malignancy without BM penetration
Erythroplasia of Queyrat - carcinoma in situ of penis
DCIS
Down regulation
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility

9. What are risk factors for placenta acreta
Prior c section - inflammation - placenta previa
Inc in total - and dec in free fraction
One of the centrioles
Brenner tumor

10. Which androgen is responsible for differentiation of epididymis - vas deferens - seminal vesicles - internal genitalia (except prostate)
Testosterone
Prior c section - multiparity
Milk letdown - uterine contractions?
Dilation and curettage and methotrexate

11. What is the flaggelum derived from
Invasive lobular
Enlarged bilateral cystic ovaries - amenorrhea - infertility - obesity - and hirsutism
One of the centrioles
46 xx

12. ecsematous patches on nipple and/or vulva - suggests underlying carcinoma

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13. When does spermatogenesis begin?
Tunica vaginalis lesions
2nd week of proliferative phase
GnRH from hypoTh - LH and FSH from ant pituitary
Puberty

14. defect in androgen receptor resulting in normal appearing female - rudimentry vagina - no uterus or uterine tubes
Cirrhosis - testicular tumor - puberty - old age - klinefelter's syndrome - drugs
Mucinous cystadenoma
Placental ischemia due to impaired vasodltn of spiral arteries resulting in increased vasc tone
Androgen insensitivity syndrome - 46 XY

15. Between What two phases does the sperm acquire the acrosome - flagellum - and middle piece
Final stage of spermatogenesis - spermiogenesis - spermatid to spermatozoa
Erythroplasia of Queyrat - carcinoma in situ of penis
Seminiferous tubules - epididymis - vas deferens - ejaculatory ducts - nothing - urethra - penis
Varicocele

16. how does BPH present
Uterus
Complete
Fibrosis
Inc freq of urination - nocturia - difficulty starting/stopping urination - dysuria

17. breast path - diseeases of the lobules
PSA
Lobular carcinoma - sclerosing adenosis
Development of genitalia and breast - growth of follicle - hormonal interactions with HPG accesss - and inc transport proteins like SHBG inc HDL and dec LDL
Broad ligament

18. what stimulation is required to maintain milk production and What is the pathway
Klinefelter's - XXY
Broad ligament
Suckling - inc oxytocin - prolactin
Mucinous cystadenoma

19. From What tissues to malignant breast tumors arise?
Whorled pattern of smooth muscle bundles
Sarcoma botryoides - a rhabdomyosarcoma variant
Mammary duct epithelium or lobular glands
Andogren binding protein - anti mullerian hormone

20. How long does it take for sperm to fully develop
IV mag sulfate - diazepam
During fetal life
PSA
2 months

21. Connects ovaries to lateral pelvic wall - contains ovarian vessels
Both ovary and testicular tissue present - ambiguous genitals - rare 46 XX - 47XXY
The centrioles
Suspensory ligament of ovaries
Increase

22. Testosterone and estrogen in androgen insensitivity syndrome
Andogren binding protein - anti mullerian hormone
Increase (and LH)
Syncytiotrophoblasts of placenta
Endocervix

23. 2 sperm + empty egg
20 to 40
Complete
Hyperthyroidism - contains functional thyroid tissue
Develop both male and female internal genitalia and male external genitalia

24. What are the most common tumors in all females?
No
Defective androgen receptor
Myometrial tumors
Testosterone secreting tumor - exogenous steroids

25. Which hydatidiform mole has the greater risk for malignancy
Visceral - somatic nerves in pudendal
Complete
50 times
Fibrcystic change - ductal cancer

26. leiomyoma and leiosarcoma have an increased incidence in which ethnic group
Broad ligament
Round ligament of the uterus
Blacks
Klinefelter's - XXY

27. What are the treatments for BPH
Lobular carcinoma - sclerosing adenosis
Comedocarcinoma
Alpha1 antagonists - terazosin - tamsulosin - finasteride
Abacterial

28. testicular atrophy - eunochoid body shape - tall - long extremities - gynecomastia - inactivated X chromosome - dysgenesis of seminiferous tubules - decreased inhibin - abnormal leydig cell function

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29. What does HHAVOC stand for in menopause
Hirsutism - hot flashes - atrophy of the vagina - osteoporosis - coronary artery disease
Ovary
Inhibit cGMP breakdown
Suckling - inc oxytocin - prolactin

30. Breast path - disease that occurs at the nipple

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31. what bacteria is commone in acute prostatitis
Hemorrhage
E coli
Lobular carcinoma - sclerosing adenosis
Sertoli cell tumor

32. Vaginal sqamous cell carcinoma is most often seconday From which site?
1 week - 2 weeks
Unopposed estrogen - obesity - diabetes - HTN - nulliparity - late menopause
Testosterone - DHT - androstenedione
Cervix

33. What does the tail go onto to form
Lack of spermatogenesis due to inc temp of testis inside body and associated risk of germ cell tumors
Sprinolactone - digitalis - cimetidine - alchohol - ketoconazole
Inhibit cGMP breakdown
The centrioles

34. What is the presentation of prostatitis
Abruptio placentae
69 xxy
Dysuria - frequency - urgency - low back pain
Congenital adrenal hyperplasia - exogenous administration of steroids

35. Which system and nerve allow for erection in the male?
Left gonadal vein - left renal vein - IVC
Estradiol and possible growth promoting effects of DHT
PANS - pelvic nerve
Milk letdown - uterine contractions?

36. What substances other than inhibin do sertoli cells produce?
Immature
Intraductal papilloma
1 week - 2 weeks
Andogren binding protein - anti mullerian hormone

37. What is the lymphatic drainage of the distal 1/3 of the vagina/scrotum/vulva
Fibromas
Superficial inguinal lymph nodes
Choriocarcinoma
Fat necrosis

38. histologic type of fibrocystic with hyperplasia of breast stroma
Adrenal gland
Ovarian > cervical > endometrial
Fibrosis
Inhibition LH and FSH

39. Endometriosis is characterized By what clinical picture?
Low progesterone
Haploid - 2N - 23 sister chromatids
Round ligament of uterus
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility

40. Invasive carcinoma of the cervix is usually caused By what kind of malignancy
Squamous cell carcinoma
Mimics LH
The ampulla - occurs within 1 day of ovulation
Calcifications

41. tumor is ductal with caseous necrosis
Comedocarcinoma
Right gonadal vein - IVC
Seminoma
Stimulates testosterone release from leydig cells

42. tumor with orderly row of cells - often multiple and bilateral
Invasive lobular
Malignant in males not in females
Ovarian > cervical > endometrial
DCIS

43. What is the genetic material in the primary oocyte?
Corpus luteum cyst
Myometrial invasion
Oligohydramnios
Diploid - 4N - 46 sister chromatids

44. What does the SRY gene do
Testis determining factor
Fallopian tube
Klinefelter's - XXY
Necrosis - hemorrhage - can protrude from the cervix and bleed - tendency to recur

45. What estrogen does the placenta secrete
Metaphase
Prior c section - inflammation - placenta previa
Induces and maintains lactation - decreases reproductive function
Estradiol

46. frequent bu irregular cycles
Metrorrhagia
2nd week of proliferative phase
Increase
Prophase

47. What metastasis is most common with prostatic adenocarcinoma
Right gonadal vein - IVC
Seminiferous tubules - epididymis - vas deferens - ejaculatory ducts - nothing - urethra - penis
Calcifications
Osteoblastic in bone

48. in chronic prostatitis is bacterial or abacterial more common
Chromosomal abnormalities
Endometrial > ovarian> cervical (in US)
Abacterial
6

49. Which side is varicocele more common on...
Left
17beta estradiol
Sertoli cell tumor
Krukenburg tumor

50. Why does the skin resemble an orange peel in inflammatory type of maligantn breast tumor
Inc estrogen - inc total nunmber of cycles - older age at 1st live birth - obesity
Neoplastic cells block lymphatic drainage
Epithelial hyperplasia
Develop both male and female internal genitalia and male external genitalia