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Reproductive

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Where is SCC of the penis more common and What is it associated with
Fibrocystic disease
Asia - Africa - S. America - HPV - lack of circumcision
Decrease
Fertilization 'an egg met a sperm'

2. Which androgen is responsible for the deepening of the voice
Fibrosis
Inc Ca in - smooth muscle contraction - vasocxn - antierectile
Testosterone
Paget's disease - breast abscess

3. which cysts results from gonadotropin stimulation and is associated with choriocarcinoma and moles
Hydatidiform mole
Necrosis - hemorrhage - can protrude from the cervix and bleed - tendency to recur
Theca - leutin cysts
Acute mastitis

4. What can happen with no sertoli cell or lack of anti mullerian hormone
Fallopian tube
Aortic bicuspid valve
Develop both male and female internal genitalia and male external genitalia
Fibroadenoma

5. Which cells secrete beta hCG
Hydatidiform mole
Post menopausal
Inc AFP and hCG
Trophoblasts

6. What is the most common gynecologic malignancy
Superficial inguinal lymph nodes
Endometrial carcinoma
Aortic bicuspid valve
Estrogen/progesterone receptors - erb - B2 - HER2 an EGF receptrs

7. What are the pathologic features of leiosarcoma
Stimulation of secretion - but blocks its action at the breast
Mature teratoma
Necrosis - hemorrhage - can protrude from the cervix and bleed - tendency to recur
DCIS

8. Where does LH work - what enzyme works there and what product is secreted
Down regulation
Endometrial carcinoma
Theca cell - desmolase - androstenedione
Round ligament of uterus

9. androblastoma from sex cord stroma
Lack of spermatogenesis due to inc temp of testis inside body and associated risk of germ cell tumors
Phyllodes tumor
Ectopic preg
Sertoli cell tumor

10. What is the right venous drainage of the ovary/testis
During fetal life
Right gonadal vein - IVC
Turner's XO
Serous cystadenocarcinoma

11. breast abscess - during breast feeding with increased risk of bacterial infxn through cracks in the nipple
Weight loss - OCP - gonadotropin analogs - clomiphene - sprinolactone - surgery
Acute mastitis
Retrograde mentrual flow or ascending infection
5 alpha reductase def

12. What does progesterone do to estrogen receptors
Down regulation
Oligomenorrhea
Mucinous cystadenocarcinoma
Proliferation

13. What is the typical cell change in HPV infection
No
Intraductal papilloma
Testosterone
Koilocytitic

14. 20% of ovarian tumors - benign - lined with fallopian tube like epithelium
Kallman
Endometrial carcinoma
The semiT and the blood vessels
Serous cystadenoma

15. histologic subtype of fibrocystic with inc acini and intralobular fibrosis
Prementsrual breast pain and multiple lesions
The semiT and the blood vessels
Complete
Sclerosing adenosis

16. Where is testosterone converted to estrogen
Placenta previa
Spermatocele
Sertoli cells - and adipose tissue via aromatase
HPV 16 - 18

17. vaginal carcinoma affecting girls < 4 spindle shaped tumors cells that are desmin positive
Follicular phase varies - luteal phase is 14
Prostatic acid phosphatase and PSA
Medullary
Sarcoma botryoides - a rhabdomyosarcoma variant

18. What effect does NO have on smooth muscle in erectile tissues
Inc cGMP - smooth muscle relax - vasodltn - proerectile
Ovarian > cervical > endometrial
Increase (and LH)
Final stage of spermatogenesis - spermiogenesis - spermatid to spermatozoa

19. What does increasing estrogen do to GnRH receptors on ant pit - and What does this lead to...
Good - late metastasis
Adenomyosis
Upregulation - LH surge - ovulation
Abruptio placentae

20. What effect does NE have on smoothe muscle in the erectile tissues
Choriocarcinoma
Testosterone
Inc Ca in - smooth muscle contraction - vasocxn - antierectile
Dysuria - frequency - urgency - low back pain

21. Endometriosis is characterized By what clinical picture?
Congenital adrenal hyperplasia - exogenous administration of steroids
Inc cGMP - smooth muscle relax - vasodltn - proerectile
Hyperestrogenism
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility

22. What is the common presentation of metastasis in prostate cancer
Hypogondadotropic hypogonadism
GnRH from hypoTh - LH and FSH from ant pituitary
Prostatic acid phosphatase and PSA
Low back pain with increased serum alk phos

23. Wher does dysplasia and carcinoma in situ of the cervix usually begin
Stimulates sertoli cells to produce ABP and inhibin
Squamo - columnar jxn
Hydrocele
Fibrocystic disease

24. What is the treatment for hydatidiform mole
Fallopian tube
Dilation and curettage and methotrexate
Abruptio placentae
Cardinal ligament

25. What is the pattern seen in leiomyoma
Diploid - 4N - 46 sister chromatids
Abruptio placentae
Aortic bicuspid valve
Whorled pattern of smooth muscle bundles

26. What are the 4 sources of progesterone
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility
Corpus luteum - placenta - adrenal cortex - testes
Invasive lobular
Tight junctions between sertoli cells

27. gray - soliarty - crusty plaque - usually on the shaft of the penis or on the scrotum - peak incidence in 5th decade of life - can progress to invasive SCC in < 10% of cases

28. hemorrhage into persistent corpus luteum
Follicular phase varies - luteal phase is 14
Maintenance
Corpus luteum cyst
Andogren binding protein - anti mullerian hormone

29. What does progesterone do in the endometrium
Stimulate glandular secretions - and spiral artery development
Adolescents
DES in utero (DES is a sythetic estrogen)
Invasive ductal

30. What does progesterone do to body temp
Syncytiotrophoblasts of placenta
Upregulation
Fibrcystic change - ductal cancer
Increase

31. What common valvular abnormality is common in Turner's
Inc freq of urination - nocturia - difficulty starting/stopping urination - dysuria
Stimulate glandular secretions - and spiral artery development
Round ligament of uterus
Aortic bicuspid valve

32. Which system and nerve are responsible for emission
Defective androgen receptor
Peyronie's dz
Unopposed estrogen - obesity - diabetes - HTN - nulliparity - late menopause
SANS - hypogastric nerve

33. when do primary oocytes complete meiosis I
Bicornute uterus
Smooth muscle
Just prior to ovulation
Testosterone secreting tumor - exogenous steroids

34. headache - blurred vision - abdominal pain - edema of face and extremeties - altered mentation - hyperreflexia in pregnancy
Myometrial tumors
Preeclampsia clinical
Trophoblasts
Inhibit cGMP breakdown

35. When does endometiral carcinoma usually occur
Severe bleeding iron def anemia - miscarriage
Chocolate cyst
55-65
Uterus

36. What is hydatidiform mole and precurosor of...
Sertoli cells - and adipose tissue via aromatase
Choriocarcinoma
Testicular lymphoma
Inc freq of urination - nocturia - difficulty starting/stopping urination - dysuria

37. What occurs to a fibroadenoma during pregnancy and menstruation and why
Estradiol and possible growth promoting effects of DHT
Left
Seminoma
Inc size and tenderness with inc estrogen

38. histological subtype of fibrocystic with inc number of epithelial cell lauers in terminal duct lobule - women over 30
Bicornute uterus
During fetal life
Calcifications
Epithelial hyperplasia

39. What is the serum marker for BPH
Dilation and curettage and methotrexate
PSA
Myometrial tumors
Slight increase - 1.5 to 2

40. What is the lymphatic drainage of the proximal 2/3 of the vagina/uterus
Hypogondadotropic hypogonadism
Abacterial
Obdurator - exterinal iliac - hypogastic nodes
Relaxation

41. When does spermatogenesis begin?
Bowenoid papulosis - carcinoma in situ of the penis
Prostate growth - balding - and sebaceous gland activity
Paget's disease
Puberty

42. What is DHT responsible for in early development?
Dysgerminoma
Dilation and curettage and methotrexate
Smooth muscle
Differentiation of penis - scrotum and prostate

43. When are phyllodes tumors most common
Delivery of fetus
Premature ovarian failure (Pof)
In the 6th decade of life
During fetal life

44. What are causes of female pseudoHerm
Congenital adrenal hyperplasia - exogenous administration of steroids
DIC
Paget cell
Inc freq of urination - nocturia - difficulty starting/stopping urination - dysuria

45. What pathologic states cause increases in hCG
Hydatidiform moles - choriocarcinoma - gestational trophoblastic tumors
Fibromas
Squamo - columnar jxn
Mammary duct epithelium or lobular glands

46. disagreement between the phenotypic and gonadal sex
Choriocarcinoma
Pseudohermaphroditism
Lateral invasion can block ureters causing renal failure
Estrogen/progesterone receptors - erb - B2 - HER2 an EGF receptrs

47. What is the clinical manifestation of PCOS
Broad ligament
Prior c section - inflammation - placenta previa
Peripheral conversion of androgens
Enlarged bilateral cystic ovaries - amenorrhea - infertility - obesity - and hirsutism

48. malignant - pseudomyxoma pertonei - intraperitoneal accumulation of mucinous material from ovarian or appendiceal tumor
Esophogeal/duodenal atresia - can't swallow - anencephaly
Mucinous cystadenocarcinoma
Estradiol and possible growth promoting effects of DHT
Prior c section - multiparity

49. cystic swelling of chorionic villi and proliferation of chorionic epithelium that presents with abnormal vaginal bleeding
Lack of spermatogenesis due to inc temp of testis inside body and associated risk of germ cell tumors
Testicular lymphoma
Prematurity
Hydatidiform mole

50. What is the genetic material in the secondary oocyte?
Haploid - 2N - 23 sister chromatids
GnRH from hypoTh - LH and FSH from ant pituitary
Ectocervix
Erythroplasia of Queyrat - carcinoma in situ of penis