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Reproductive

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. What is the venous drainage of the left ovary/testis?
Left gonadal vein - left renal vein - IVC
Fibroadenoma - phyllodes tumor
Mucinous cystadenoma
Ovarian > cervical > endometrial

2. non neoplastic endometrial glands/stroma in abnormal locations outsdie the uterus
Endometriosis
Metrorrhagia
Maintenance
Myometrial invasion

3. What substances other than inhibin do sertoli cells produce?
Delivery of fetus
Andogren binding protein - anti mullerian hormone
No
Adrenal gland

4. What sequelae are associated with leiomyoma
17beta estradiol
Severe bleeding iron def anemia - miscarriage
Fibromas
Oligohydramnios

5. Between What two phases does the sperm acquire the acrosome - flagellum - and middle piece
Koilocytitic
Tight junctions between sertoli cells
Final stage of spermatogenesis - spermiogenesis - spermatid to spermatozoa
GnRH from hypoTh - LH and FSH from ant pituitary

6. What is the lymphatic drainage of the distal 1/3 of the vagina/scrotum/vulva
Superficial inguinal lymph nodes
Stimulates sertoli cells to produce ABP and inhibin
Androgen insensitivity syndrome - 46 XY
Cervix

7. 20% of ovarian tumors - benign - lined with fallopian tube like epithelium
Chromosomal abnormalities
Premature ovarian failure (Pof)
Serous cystadenoma
Ectopic preg

8. most common testicular cancer in older men
Testicular lymphoma
Turner's XO
PCOS
Fructose

9. What is a complication of invasive carcinoma
Koilocytitic
Lateral invasion can block ureters causing renal failure
Blacks
Low back pain with increased serum alk phos

10. Which gynecologic tumors have the worst prognosis?
Ovarian > cervical > endometrial
PCOS
Estrogen/progesterone receptors - erb - B2 - HER2 an EGF receptrs
Estradiol and possible growth promoting effects of DHT

11. Which hydatidiform mole has the greater risk for malignancy
Left gonadal vein - left renal vein - IVC
Complete
Increase in size in pregs - decrease in size meno - estrogen sens
Menopause

12. Which androgen is responsible for the closing of the epiphyseal plate
Uterus
Testosterone
Oligomenorrhea
Cerebral hemorrhage and ARDS

13. testicular masses that can be transilluminated
Feedback inhibition
Brenner tumor
Tunica vaginalis lesions
1000 times

14. Wher does dysplasia and carcinoma in situ of the cervix usually begin
Placental ischemia due to impaired vasodltn of spiral arteries resulting in increased vasc tone
Golgi
Squamo - columnar jxn
Bowenoid papulosis - carcinoma in situ of the penis

15. What are risk factors for abruptio placentae?
Fibroadenoma
69 xxy
Hirsutism - hot flashes - atrophy of the vagina - osteoporosis - coronary artery disease
Smoking - HTN - cocaine

16. predisposing factor to clear cell adenocarcinoma of the vagina
Choriocarcinoma
Polyhydramnios
Increase
DES in utero (DES is a sythetic estrogen)

17. What is the source of estrogen after menopause
Hyperthyroidism - contains functional thyroid tissue
Ovarian > cervical > endometrial
Peripheral conversion of androgens
Sertoli cells

18. eclampsia
Preeclampsia + siezures
50 times
Adolescents
Paget cell

19. When are phyllodes tumors most common
Follicular phase varies - luteal phase is 14
Fibrcystic change - ductal cancer
In the 6th decade of life
Hydrocele

20. when do primary oocytes begin meiosis I
Para - aortic lymph nodes
Testosterone
During fetal life
Estrogen overstimulation

21. How long does it take for sperm to fully develop
Epithelial hyperplasia
2 months
Stimulation of secretion - but blocks its action at the breast
Syncytiotrophoblasts of placenta

22. What converts testosterone to DHT
17beta estradiol
Syncytiotrophoblasts of placenta
History of infertility - salpingitis - ruptured appendix - prior tubal surgery
5 alpha reductase - inhibited by finesteride

23. in chronic prostatitis is bacterial or abacterial more common
Erythroplasia of Queyrat - carcinoma in situ of penis
Abacterial
5 alpha reductase - inhibited by finesteride
Testosterone

24. inc AFP - schiller duvel bodies - yellow mucinous
Acute mastitis
Corpus luteum - placenta - adrenal cortex - testes
Anovulatory cycles - hormone replacement therapy - PCOS - granulosa cell tumor
Yolk sac - endodermal sinus - tumor

25. What is indicative of a poor prognosis for endometrial carcinoma
Choriocarcinoma
Myometrial invasion
Development of genitalia and breast - growth of follicle - hormonal interactions with HPG accesss - and inc transport proteins like SHBG inc HDL and dec LDL
Increase (and LH)

26. Which cells secrete beta hCG
Cirrhosis - testicular tumor - puberty - old age - klinefelter's syndrome - drugs
1000 times
Sertoli cells
Trophoblasts

27. bundles of spindle shaped fibroblasts - pulling sensation in the groin
Fructose
Fibromas
Adrenal gland
Call exner bodies

28. gynecological tumors from highest incidence to lowest
Cerebral hemorrhage and ARDS
Endometrial > ovarian> cervical (in US)
Retrograde mentrual flow or ascending infection
Premature ovarian failure (Pof)

29. What is the clinical manifestation of PCOS
Estradiol > estrone > estriol
Testosterone
Enlarged bilateral cystic ovaries - amenorrhea - infertility - obesity - and hirsutism
Post menopausal bleeding

30. malignancy in ovaries - testis - sacrococcygeal area of young children - yellow friable solid masses with 50% having schiller - duval bodies
Yolk sace - endodermal sinus - tumor
Pseudohermaphroditism
SANS - hypogastric nerve
Estrogen - LH surge - ovulation - progesterone from CL - menstruation

31. What effect does NO have on smooth muscle in erectile tissues
Relaxation
Granulosa cell tumor
Sarcoma botryoides - a rhabdomyosarcoma variant
Inc cGMP - smooth muscle relax - vasodltn - proerectile

32. Vaginal sqamous cell carcinoma is most often seconday From which site?
Sertoli cell tumor
Multiple sexual partners - also HIV and early sexual intercourse
Cervix
Mimics LH

33. What is the average age of onset for menopause
51 yo
Peripheral adipose tissue
Follicular cyst
Ovary

34. triad of ovarian fibroma - ascites - hydrothorax
Stimulation of secretion - but blocks its action at the breast
During fetal life
Meigs syndrome
S aureus

35. What are the associated risk factors for malignant breast tumors
Fibrosis
Neoplastic cells block lymphatic drainage
Serous cystadenocarcinoma
Inc estrogen - inc total nunmber of cycles - older age at 1st live birth - obesity

36. What are the risk factors for endometrial hyperplasia
Koilocytitic
Anovulatory cycles - hormone replacement therapy - PCOS - granulosa cell tumor
Blacks
Prementsrual breast pain and multiple lesions

37. What does gynecomastia result from?
Low progesterone
Smoking - HTN - cocaine
Hyperestrogenism
Spermatogonia (germ cells)

38. breast path - diseeases of the lobules
Obdurator - exterinal iliac - hypogastic nodes
Endocervix
Diploid - 4N - 46 sister chromatids
Lobular carcinoma - sclerosing adenosis

39. Which androgen is responsible for differentiation of epididymis - vas deferens - seminal vesicles - internal genitalia (except prostate)
Pseudohermaphroditism
Testosterone
Bowenoid papulosis - carcinoma in situ of the penis
Post menopausal

40. what bacteria is commone in acute prostatitis
Placenta previa
Cirrhosis - testicular tumor - puberty - old age - klinefelter's syndrome - drugs
Theca cell - desmolase - androstenedione
E coli

41. What is associated with sclerosing adenosis?
Ectocervix
Diploid - 4N - 46 sister chromatids
Calcifications
Brenner tumor

42. What is the treatment for preeclampsia
69 xxy
Inc AFP and hCG
Delivery of fetus
Spermatocele

43. Where is SCC of the penis more common and What is it associated with
Asia - Africa - S. America - HPV - lack of circumcision
Cyclic bleeding - chocolate cysts - severe menstrual related pain - infertility
BPH
Proliferation

44. which cysts results from gonadotropin stimulation and is associated with choriocarcinoma and moles
Small infiltrating glands with prominent nucleoli
Spermatogonia (germ cells)
Fibrcystic change - ductal cancer
Theca - leutin cysts

45. What is the most common form of male pseudoHerm
Feedback inhibition
Inhibit cGMP breakdown
Abruptio placentae
Androgen insensitivity syndrome

46. Which androgen is responsible for the deepening of the voice
No
Testosterone
Retrograde mentrual flow or ascending infection
Trophoblasts

47. What complications are associated with polyhydramnios

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48. What occurs to a fibroadenoma during pregnancy and menstruation and why
Right gonadal vein - IVC
Chocolate cyst
Inc size and tenderness with inc estrogen
Oligohydramnios

49. hemorrhage into persistent corpus luteum
Corpus luteum cyst
PCOS
Menopause
Yolk sac - endodermal sinus - tumor

50. What are common causes of hyperestrogenism

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