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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Diffuse nodular diabetic glomerulosclerosis






2. Deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT) - low purine metabolism - high uric acid - thus gout - mental retardation - choreoathetosis - spasticity - self mutilation - aggressiveness






3. Aka trisomy 13 - mental retardation - microcephaly - micropthalmia - brain abnormalities - cleft lip/palate - polydactyly - rockerbottom feet - congenital heart dx






4. X linked - aka immunodeficiency with thrombocytopenia and eczema - total immunoglobulins often normal - recurrent infections






5. Sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver - spleen - lymph nodes and skin






6. Severe unconj hyperbilirubinemia due to deficient glucuronyl transferase






7. Associated with breast alone (isn't one of these associated with prostate? Check)






8. Autosomal recessive - hepatitis - accumulation of copper due to transport problem - low ceruloplasmin seen - kayser fleischer rings in eyes






9. Gene product inhibits apoptosis






10. Mutation = paroxysmal nocturnal hemoglobinuria






11. Parkinsonism with autonomic dysfunction and orthostatic hypotension






12. Acute inflammatory demyelinating dx primarily involving peripheral nerves






13. Seen in urine of patients with multiple myeloma - Ig light chain either k or l






14. Tumor suppressor mutated in Von Recklinhousen






15. Dysplastic cell seen in HPV






16. Port wine stain on face - ipsilateral glaucoma - vascular lesions of ocular choroidal tissue - extensive hemangiomatous involvement of meninges






17. Gene product facilitates apoptosis - decreases bcl::2 and increases Bax






18. Intracytoplasmic inclusions seen in leydig cell tumors p283






19. Osteophytes at DIP joints






20. Located on xsome 6 - mutation here = hereditary hemochromatosis






21. Intra::alveolar hemosiderin - laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN






22. Tumor suppressor mutated in breast and ovary






23. Autoimmune thyroiditis - hyperthyroid - exophthalmos - increased in HLA DR3 and HLA B8 pos people






24. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3






25. Tumor suppressor mutated in wilms tumor






26. Iron deficient anemia associated with upper::esophageal web






27. Similar to Hurler - deficient L iduronosulfate sulfatase - accumulations of heparin sulfate and dermatan sulfate - hepatospenomegaly - micrognathia - retinal degeneration - joint stiffness - mental retardation - cardiac lesions






28. Autoimmune hypothyroid - hurthle cells common






29. Aka pulseless dx - inflammation and stenosis of medium and large sized arteries - often aortic arch thus aortic arch syndrome






30. Mucinous cell - characteristic of stomach CA met to ovary (krukenberg tumor)






31. Hemihypertrophy - macroglossia - organomegaly - neonatal hypoglycemia - various embryonal tumors - deleted WT 2 gene






32. Aka chronic progressive histiocytosis - not as bad as Letterer Siwe






33. This comes in a wet variety and a dry one - they are both Vit B1 thiamine deficiency






34. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






35. Seen in insulinoma - episodic hyperinsulinemia and hypoglycemia - CNS dysfunction - reversal of CNS probs with administration of glucose






36. Different in that it is the primary disorder - recurrent vasospasm of small arteries and venules - pallor - cyanosis - fingers and toes - young healthy women






37. Aka IgA nephropathy - deposition of IgA in mesangium - benign recurrent hematuria in kids following infection






38. Epithelial cells with eosinophilc granular cytoplasm seen in hashimoto






39. Lots of tumors - breast CA - soft tissue sarc - brain tumors - leukemias - has loss of p53 tumor suppressor gene






40. Variant of rheumatoid arthritis - splenmegally - neutropenia - RA






41. Associated with 90% cases of ankylosing spondylitis - common in rheumatoid arthritis






42. Downward displacement of cerebellar tonsils and medulla through foramen magnum






43. Pigmented iris hamartoma seen in neurofibromatosis






44. Vaginal epithelial cell with stippled appearance due to adherent coccobacilli






45. Oncogenes that code for p21 proteins which are membrane signalers






46. Vasosmasm of small vessels - most often in fingers - seen with autoimmune dx like SLE - scleroderma and others (R in CREST) - recurrent vasospasm - always secondary to underlying disorder






47. Binucleated or multinucleated giant cell seen in Hodgkin dx






48. 45 XO - female hypogonadism - hypothyroid - short - webbed neck - 1* amenorrhea p52






49. Polyostotic fibrous dysplasia - precocious puberty - caf






50. Modest elevated serum unconj bilirubin - due to decreased uptake by liver cells and reduced activity of glucuronyl transferase