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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Vasosmasm of small vessels - most often in fingers - seen with autoimmune dx like SLE - scleroderma and others (R in CREST) - recurrent vasospasm - always secondary to underlying disorder






2. Located on xsome 6 - mutation here = hereditary hemochromatosis






3. Superclavicular lymph node identifying metastatic stomach CA






4. Mutation = paroxysmal nocturnal hemoglobinuria






5. Vaginal epithelial cell with stippled appearance due to adherent coccobacilli






6. Hemangioblastoma or cavernous hemangioma of cerebellum - brainstem or retina - adenomas - cysts in liver - kidney - pancreas - and other organs - increased renal cell CA - gene = short arm of chromosome 3






7. Catastrophic adrenal insuff and vascular collapse - hemorrhagic necrosis of adrenal cortex






8. Parkinsonism with autonomic dysfunction and orthostatic hypotension






9. Aka osteopetrosis - marble bone dx - dense skeleton - failure of osteoclastic activity






10. Triad of ovarian fibroma - ascites - hydrothorax






11. Pigmented iris hamartoma seen in neurofibromatosis






12. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






13. Sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver - spleen - lymph nodes and skin






14. Deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT) - low purine metabolism - high uric acid - thus gout - mental retardation - choreoathetosis - spasticity - self mutilation - aggressiveness






15. Scheinker syndrome :: prion dx - fatal familial insomnia






16. Associated with papillary thyroid CA






17. Iron deficient anemia associated with upper::esophageal web






18. Associated with 90% cases of ankylosing spondylitis - common in rheumatoid arthritis






19. Aka neurofibromatosis - neurofibromas in skin - schwannomas of CN VIII - caf






20. Eosinophilic intracytoplasmic inclusions in hippocampus and purkinje cells seen in rabies infection






21. Unknown etiology - necrotizing granulomatous vasculitis of small to medium sized vessels of the respiratory tract - kidneys - and other organs - circulating C- ANCAs






22. On lymph node biopsy - seen with Burkitt lymphoma






23. Deficient glucose -6- phosphatase - accumulation of glycogen in liver and kidney - hepatomegaly - hypoglycemia






24. Malignant lymphoma with features resembling inflammatory disorder - young men - Reed Sternburg cells






25. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






26. Mucopolysaccharidosis - deficient a L iduronidase - accumulations of heparin sulfate and dermatan sulfate in heart - brain - liver - and other organs - progressive - hepatosplenomagaly - dwarfism - gargoyle - like facies - stubby fingers - corneal cl






27. Oligohydramnios causes fetus to be smashed






28. Aka osteitis deformans - increased osteoclastic and osteoblastic activity






29. Aka angiokeratoma corporis diffusum universal - deficient a::galactosidase A - accumulate ceramide trihexoside - skin lesions angiokeratomas - fever - burning pain in extremities - cardiovascular and cerebrovascular involvement - death as adult by re






30. Paraneoplastic synd looks like myasthenia gravis - often small cell lung CA






31. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






32. Aka pituitary cachexia - generalized panhypopituitarism






33. Retinoblastoma on chromosome 13






34. Appears as multiple wart - like lesions resembling condyloma accuminatum






35. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3






36. Combination of hyperthyroidism - nodular goiter - absence of exophthalmos






37. Ovarian tumor resembling bladder transitional epith






38. Paracentric inversion or translocation with 17 associated with papillary thyroid CA






39. Thrombotic occlusion of major hepatic veins - abnormal pain - jaundice - hepatomegaly - acites - liver failure - assoc with polycythemia vera - hepatocellular CA - and other common neoplasms - may occur as a complication of pregnancy






40. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)






41. Deficient glucocerebrosidase - accumulation of glucocerebroside in cells of mononuclear phagocyte system 3 types ::






42. Also seen in urine of MM - stacks of RBCs - will have high ESR






43. Aka subcortical leukoencephalopathy - assoc with HTN - multiple lacunar infarcts and progressive demyelination in subcortical area






44. Aka antiglomerular basement membrane dx - antibodies against alveolar and glomerular basement membranes - linear immunoflorescence






45. Intra::alveolar hemosiderin - laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN






46. Eczematoid lesion of nipple areola - large cells with clear 'halo like' area - invade epidermis - underlying ductal CA






47. Aka velocardiofacial syndrome and CATCH 22 syndrome - micro deletion of 22q11 - Cardiac abnormalities - Abnormal facies - T cell deficit due to thymic hypoplasia - Cleft palate - Hypocalcemia due to hypoparathyroidism - from poor development of 3rd a






48. Philadelphia chromosome - CML bcr abl fusion c - abl on 9 - bcr on 22






49. Osteophytes at PIP joints






50. Radiologic appearance of periostium in bone tumors