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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Similar to Hurler - deficient L iduronosulfate sulfatase - accumulations of heparin sulfate and dermatan sulfate - hepatospenomegaly - micrognathia - retinal degeneration - joint stiffness - mental retardation - cardiac lesions






2. Aka IgA nephropathy - deposition of IgA in mesangium - benign recurrent hematuria in kids following infection






3. Radiologic appearance of periostium in bone tumors






4. Aka antiglomerular basement membrane dx - antibodies against alveolar and glomerular basement membranes - linear immunoflorescence






5. DsDNA antibodies and Sm Smith antigen = highly specific for SLE






6. Similar to Dubin Johnson with no black liver






7. Small follicles filled with eosinophilic secretion - diagnostic feature of granulose cell tumor






8. Philadelphia chromosome - CML bcr abl fusion c - abl on 9 - bcr on 22






9. Non::neoplastic tumor like masses - fibrous replacement of resorbed bone






10. Small round blue cell tumor of bone - long bones - kids - 11:22 transloc






11. Aspirin toxicity seen in kids after acute febrile viral dx - microvesicular fatty change in liver and encephalopathy






12. Nystagmus - intention tremor - scanning speech - seen in MS






13. Autoimmune thyroiditis - hyperthyroid - exophthalmos - increased in HLA DR3 and HLA B8 pos people






14. Autosomal recessive - unusually large platelets - lack of 'GPIb IX V'






15. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3






16. Ring of copper deposited around iris seen in Wilson






17. Binucleated or multinucleated giant cell seen in Hodgkin dx






18. At least 2 X and one Y - hypogonadism - tall - gynecomastia - low testosterone - high pituitary gonadotropins - infertility -






19. Seen in granuloma inguinale - multiple organisms filling large histiocytes






20. Variant of rheumatoid arthritis - aka juvenile rheumatoid arthritis






21. This comes in a wet variety and a dry one - they are both Vit B1 thiamine deficiency






22. Paternal transmission del (15)(q11q13) - hypogonad - hypotonia - mental retardation - behavior probs - uncrontrolled appetite






23. Manifestation of lymphplasmocytic lymphoma - B cell neoplasm






24. Seen in hyperacute rejection - = acute inflammation - fibrinoid necrosis of small vessels - and extensive thrombosis






25. Protooncogene mutated in medulary thyroid CA (MENII)






26. Aka acute disseminated langerhans cell histiocytosis - aggressive - usually fatal - kids hepatosplenomegaly - LAD - pancytopenia - pulmonary involvement - recurrent infections






27. Infectious disorder - caused postencephalitic parkinsonism






28. Autosomal recessive - hepatitis - accumulation of copper due to transport problem - low ceruloplasmin seen - kayser fleischer rings in eyes






29. Seen in Down synd - small white spots on periphery of iris






30. Seen in papillary thyroid CA






31. Hereditary nephritis associated with nerve deafness and ocular disorders - mutation in gene for the a5 chain of type IV collagen






32. Defective in x- linked brutons agammaglobulinemia - B- cell tyrosine kinase






33. Nuclei arranged in horseshoe - shaped pattern about periphery of cell - characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)






34. Hemihypertrophy - macroglossia - organomegaly - neonatal hypoglycemia - various embryonal tumors - deleted WT 2 gene






35. Pigmented iris hamartoma seen in neurofibromatosis






36. = MEN1






37. Occurs in SLE - small vegitations on either or both surfaces of valves






38. Aka congenital megacolon - dilation of colon due to absence of ganglion cells






39. Metastatic stomach CA to ovary






40. Paraneoplastic synd looks like myasthenia gravis - often small cell lung CA






41. Acute promyelocytic leukemia PML gene on 15 and RARa on 17






42. Deficient hexosaminidase A - GM2 ganglioside accumulation - especially in neurons - CNS degeneration - mental/motor deterioration - blindness - cherry red spot on macula - death by 4 years of age






43. Chromosome 19 - allele common in alzheimers






44. Associated with 90% cases of ankylosing spondylitis - common in rheumatoid arthritis






45. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






46. Oncogenes that code for p21 proteins which are membrane signalers






47. Also seen in urine of MM - stacks of RBCs - will have high ESR






48. Intracytoplasmic proximal dentritic eosinophilic inclusions consisting of actin seen in Alzheimers






49. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






50. Vaginal epithelial cell with stippled appearance due to adherent coccobacilli