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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






2. Mutation here causes pseudohypoparathyroidism






3. Intracytoplasmic inclusions seen in leydig cell tumors p283






4. Aka trisomy 18 - mental retardation - prominent occiput - micrognathia (small jaw) - low::set ears - rocker::bottom feet - finger deformities - congenital heart dx






5. Oncogenes that code for p21 proteins which are membrane signalers






6. Aka acute disseminated langerhans cell histiocytosis - aggressive - usually fatal - kids hepatosplenomegaly - LAD - pancytopenia - pulmonary involvement - recurrent infections






7. Gene product facilitates apoptosis - decreases bcl::2 and increases Bax






8. Aggressive B- cell lymphoma - EBV - starry sky appearance - c myc






9. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






10. Lots of tumors - breast CA - soft tissue sarc - brain tumors - leukemias - has loss of p53 tumor suppressor gene






11. Parkinsonism with autonomic dysfunction and orthostatic hypotension






12. Malabsorption syndrome - Tropheryma wippelii bacilli - small intestine commonly affected - arthralgias - cardiac - and neuro symptoms






13. Defective cilia - sinusitis - bronchiectasis - situs inversus - sometimes hearing loss and male sterility






14. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)






15. Acute inflammatory demyelinating dx primarily involving peripheral nerves






16. Ring of copper deposited around iris seen in Wilson






17. Tumor suppressor mutated in breast and ovary






18. Philadelphia chromosome - CML bcr abl fusion c - abl on 9 - bcr on 22






19. Burkitts c::myc is on 8 - IG heavy chain is on 14






20. Appears as multiple wart - like lesions resembling condyloma accuminatum






21. Different in that it is the primary disorder - recurrent vasospasm of small arteries and venules - pallor - cyanosis - fingers and toes - young healthy women






22. Aka pituitary cachexia - generalized panhypopituitarism






23. Aka osteitis deformans - increased osteoclastic and osteoblastic activity






24. Autoimmune thyroiditis - hyperthyroid - exophthalmos - increased in HLA DR3 and HLA B8 pos people






25. Metastatic stomach CA to ovary






26. Osteophytes at DIP joints






27. Acute promyelocytic leukemia PML gene on 15 and RARa on 17






28. Dysplastic cell seen in HPV






29. Myc :: neuroblastoma amplicatiion correlates inversely with degree of differentiation






30. Iron deficient anemia associated with upper::esophageal web






31. Thyroid replacement by fibrous tissue - unkown origin - mimics






32. Autosomal dominant - fatal - progressive degeneration of striatum and frontal cortex with neuronal depletion and gliosis






33. Epithelial cells with eosinophilc granular cytoplasm seen in hashimoto






34. Gene product inhibits apoptosis






35. Retinoblastoma on chromosome 13






36. Primary adrenal failure






37. Paracentric inversion or translocation with 17 associated with papillary thyroid CA






38. Defective in x- linked brutons agammaglobulinemia - B- cell tyrosine kinase






39. Protooncogene mutated in medulary thyroid CA (MENII)






40. Seen in urine of patients with multiple myeloma - Ig light chain either k or l






41. Seen in Down synd - small white spots on periphery of iris






42. Sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver - spleen - lymph nodes and skin






43. Osteophytes at PIP joints






44. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






45. Abnormal WT 1 gene - intersexual disorders - nephropathy - wilms tumor






46. Nystagmus - intention tremor - scanning speech - seen in MS






47. Nuclei arranged in horseshoe - shaped pattern about periphery of cell - characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)






48. Aka lentigo maligna - precursor to lentigo maligna melanoma






49. Catastrophic adrenal insuff and vascular collapse - hemorrhagic necrosis of adrenal cortex






50. Aka trisomy 13 - mental retardation - microcephaly - micropthalmia - brain abnormalities - cleft lip/palate - polydactyly - rockerbottom feet - congenital heart dx