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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Tumor suppressor mutated in breast and ovary






2. Binucleated or multinucleated giant cell seen in Hodgkin dx






3. Seen in granuloma inguinale - multiple organisms filling large histiocytes






4. Sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver - spleen - lymph nodes and skin






5. Seen in urine of patients with multiple myeloma - Ig light chain either k or l






6. Ring of copper deposited around iris seen in Wilson






7. Aka pulseless dx - inflammation and stenosis of medium and large sized arteries - often aortic arch thus aortic arch syndrome






8. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






9. Aka subcortical leukoencephalopathy - assoc with HTN - multiple lacunar infarcts and progressive demyelination in subcortical area






10. Autosomal dominant - fatal - progressive degeneration of striatum and frontal cortex with neuronal depletion and gliosis






11. Polyostotic fibrous dysplasia - precocious puberty - caf






12. Deficient glucocerebrosidase - accumulation of glucocerebroside in cells of mononuclear phagocyte system 3 types ::






13. Oncogenes that code for p21 proteins which are membrane signalers






14. Aka IgA nephropathy - deposition of IgA in mesangium - benign recurrent hematuria in kids following infection






15. Aka allergic granulomatous angiitis - necrotizing vasculitis - variant of polyarteritis nodosa - involves pulmonary vasculature - peripheral eosinophilia - and asthma






16. Aka superior sulcus tumor - seen in bronchogenic CA - often with Horner's






17. Aka infantile progressive spinal muscular atrophy - autosomal recessive - LMN disease - infants






18. Located on xsome 6 - mutation here = hereditary hemochromatosis






19. Aka angiokeratoma corporis diffusum universal - deficient a::galactosidase A - accumulate ceramide trihexoside - skin lesions angiokeratomas - fever - burning pain in extremities - cardiovascular and cerebrovascular involvement - death as adult by re






20. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






21. Small round blue cell tumor of bone - long bones - kids - 11:22 transloc






22. Associated with 90% cases of ankylosing spondylitis - common in rheumatoid arthritis






23. Thyroid replacement by fibrous tissue - unkown origin - mimics






24. Adenomatous polyps with tumors of CNS






25. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)






26. B1 thiamine - B2 riboflavin - B3 niacin - B6 pyridoxine - B12 cobalamin - C ascorbic acid - D calciferol - E a::tocopherol






27. Oligohydramnios causes fetus to be smashed






28. Appears as multiple wart - like lesions resembling condyloma accuminatum






29. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






30. Intracytoplasmic inclusions seen in leydig cell tumors p283






31. Hemangioblastoma or cavernous hemangioma of cerebellum - brainstem or retina - adenomas - cysts in liver - kidney - pancreas - and other organs - increased renal cell CA - gene = short arm of chromosome 3






32. Paraneoplastic synd looks like myasthenia gravis - often small cell lung CA






33. Associated with papillary thyroid CA






34. Infectious disorder - caused postencephalitic parkinsonism






35. Philadelphia chromosome - CML bcr abl fusion c - abl on 9 - bcr on 22






36. Epithelial cells with eosinophilc granular cytoplasm seen in hashimoto






37. Defective cilia - sinusitis - bronchiectasis - situs inversus - sometimes hearing loss and male sterility






38. 2/neu :: oncogene (aka c - erbB2) - in breast cancer = poor prognosis






39. DsDNA antibodies and Sm Smith antigen = highly specific for SLE






40. Modest elevated serum unconj bilirubin - due to decreased uptake by liver cells and reduced activity of glucuronyl transferase






41. Osteophytes at DIP joints






42. Nystagmus - intention tremor - scanning speech - seen in MS






43. Deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT) - low purine metabolism - high uric acid - thus gout - mental retardation - choreoathetosis - spasticity - self mutilation - aggressiveness






44. Retinoblastoma on chromosome 13






45. Seen in papillary thyroid CA






46. Osteophytes at PIP joints






47. Autosomal recessive - hepatitis - accumulation of copper due to transport problem - low ceruloplasmin seen - kayser fleischer rings in eyes






48. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






49. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






50. Primary adrenal failure







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