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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Materal transmission del(15)(q11q13) - aka happy puppet syndrome - mental retardation - ataxia - seizures - inappropriate laughter






2. Mutation = paroxysmal nocturnal hemoglobinuria






3. Scheinker syndrome :: prion dx - fatal familial insomnia






4. Deficient glucocerebrosidase - accumulation of glucocerebroside in cells of mononuclear phagocyte system 3 types ::






5. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






6. Seen in urine of patients with multiple myeloma - Ig light chain either k or l






7. Mucinous cell - characteristic of stomach CA met to ovary (krukenberg tumor)






8. Manifestation of lymphplasmocytic lymphoma - B cell neoplasm






9. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






10. Seen in Down synd - small white spots on periphery of iris






11. Hereditary nonpolyposis colon cancer - DNA repair genes messed up






12. Severe unconj hyperbilirubinemia due to deficient glucuronyl transferase






13. B Thalassemia major






14. Combination of hyperthyroidism - nodular goiter - absence of exophthalmos






15. Similar to Hurler - deficient L iduronosulfate sulfatase - accumulations of heparin sulfate and dermatan sulfate - hepatospenomegaly - micrognathia - retinal degeneration - joint stiffness - mental retardation - cardiac lesions






16. Hamartomatous polyps in colon and small intest - freckles on lips - hands - genitalia - higher incidence of adeno CA of colon and other malignancies - stomach - breast - ovaries






17. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)






18. Parkinsonism with autonomic dysfunction and orthostatic hypotension






19. Subcutaneous fibrosis of dorsum of penis






20. Minute neutrophilic abscesses found within parakeratotic stratum corneum in psoriasis






21. Peripheral neuropathy - atrophy of muscles - wet - high output cardiac failure - DCM - AV shunting - hypervolemia






22. Pigmented iris hamartoma seen in neurofibromatosis






23. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






24. Small follicles filled with eosinophilic secretion - diagnostic feature of granulose cell tumor






25. Aka antiglomerular basement membrane dx - antibodies against alveolar and glomerular basement membranes - linear immunoflorescence






26. = MEN2a






27. Clear cell renal tumor seen in kids






28. Deficient sphingomyelinase - accumulation of sphingomyelin in phagocytes - foamy histiocytes in liver - spleen - lymph nodes - skin - hepatosplenomegaly - anemia fever - occasional neuro degeneration - half have cherry red spot macula






29. Area of focal interstitial myocardial inflammation characterized by fragmented collagen and fibrinoid material - by large cells (Anitschkow myocytes) and occasional multinucleated giant cells (Aschoff cells)






30. Pituitary insufficiency post - partum - low TSH ACTH






31. Follicular lymphoma IG heavy chain on 14 - bcl -2 oncogene on 18






32. Nuclei arranged in horseshoe - shaped pattern about periphery of cell - characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)






33. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3






34. Aka mucocutaneous lymph node syndrome - acute self - limited - infants and young kids - acute necrotizing vasculitis of small and medium vessels - fever hemorrhagic edema of conjunctivae - lips and oral mucosa - and cervical LAD - can cause coronary






35. Aka osteopetrosis - marble bone dx - dense skeleton - failure of osteoclastic activity






36. Variant of rheumatoid arthritis - aka juvenile rheumatoid arthritis






37. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






38. Different in that it is the primary disorder - recurrent vasospasm of small arteries and venules - pallor - cyanosis - fingers and toes - young healthy women






39. Tumor suppressor mutated in wilms tumor






40. Aka lentigo maligna - precursor to lentigo maligna melanoma






41. Catastrophic adrenal insuff and vascular collapse - hemorrhagic necrosis of adrenal cortex






42. Thrombotic occlusion of major hepatic veins - abnormal pain - jaundice - hepatomegaly - acites - liver failure - assoc with polycythemia vera - hepatocellular CA - and other common neoplasms - may occur as a complication of pregnancy






43. Autosomal dominant - fatal - progressive degeneration of striatum and frontal cortex with neuronal depletion and gliosis






44. Associated with 90% cases of ankylosing spondylitis - common in rheumatoid arthritis






45. Unknown etiology - necrotizing granulomatous vasculitis of small to medium sized vessels of the respiratory tract - kidneys - and other organs - circulating C- ANCAs






46. Deficient muscle phosphorylase - glycogen in skeletal muscle - cramps with exertion






47. Occurs in SLE - small vegitations on either or both surfaces of valves






48. Aspirin toxicity seen in kids after acute febrile viral dx - microvesicular fatty change in liver and encephalopathy






49. Autosomal recessive - unusually large platelets - lack of 'GPIb IX V'






50. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






Can you answer 50 questions in 15 minutes?



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