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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Downward displacement of cerebellar tonsils and medulla through foramen magnum






2. Sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver - spleen - lymph nodes and skin






3. Aka pulseless dx - inflammation and stenosis of medium and large sized arteries - often aortic arch thus aortic arch syndrome






4. Deficient fibrillin (constituent of microfibrils) - arachnodactyly - ectopia lentis - aortic aneurysm - mitral valve prolapsed






5. = MEN1






6. Occurs in SLE - small vegitations on either or both surfaces of valves






7. Oligohydramnios causes fetus to be smashed






8. Defective in x- linked brutons agammaglobulinemia - B- cell tyrosine kinase






9. Oncogenes that code for p21 proteins which are membrane signalers






10. Gene product inhibits apoptosis






11. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






12. Seen in CLL - leukemic B- cells that are fragile






13. Hereditary nonpolyposis colon cancer - DNA repair genes messed up






14. Associated with breast alone (isn't one of these associated with prostate? Check)






15. Deficient sphingomyelinase - accumulation of sphingomyelin in phagocytes - foamy histiocytes in liver - spleen - lymph nodes - skin - hepatosplenomegaly - anemia fever - occasional neuro degeneration - half have cherry red spot macula






16. Deficient hexosaminidase A - GM2 ganglioside accumulation - especially in neurons - CNS degeneration - mental/motor deterioration - blindness - cherry red spot on macula - death by 4 years of age






17. Non::neoplastic tumor like masses - fibrous replacement of resorbed bone






18. Parkinsonism with autonomic dysfunction and orthostatic hypotension






19. Combination of hyperthyroidism - nodular goiter - absence of exophthalmos






20. Aggressive B- cell lymphoma - EBV - starry sky appearance - c myc






21. Lots of tumors - breast CA - soft tissue sarc - brain tumors - leukemias - has loss of p53 tumor suppressor gene






22. Epithelial cells with eosinophilc granular cytoplasm seen in hashimoto






23. Tumor suppressor mutated in Von Recklinhousen






24. Hamartomatous polyps in colon and small intest - freckles on lips - hands - genitalia - higher incidence of adeno CA of colon and other malignancies - stomach - breast - ovaries






25. Catastrophic adrenal insuff and vascular collapse - hemorrhagic necrosis of adrenal cortex






26. Similar to Hurler - deficient L iduronosulfate sulfatase - accumulations of heparin sulfate and dermatan sulfate - hepatospenomegaly - micrognathia - retinal degeneration - joint stiffness - mental retardation - cardiac lesions






27. Single erythematous plaque on shaft of penis or scrotum






28. Seen in granuloma inguinale - multiple organisms filling large histiocytes






29. Aka angiokeratoma corporis diffusum universal - deficient a::galactosidase A - accumulate ceramide trihexoside - skin lesions angiokeratomas - fever - burning pain in extremities - cardiovascular and cerebrovascular involvement - death as adult by re






30. Similar to Dubin Johnson with no black liver






31. Aka neurofibromatosis - neurofibromas in skin - schwannomas of CN VIII - caf






32. Seen in insulinoma - episodic hyperinsulinemia and hypoglycemia - CNS dysfunction - reversal of CNS probs with administration of glucose






33. Area of focal interstitial myocardial inflammation characterized by fragmented collagen and fibrinoid material - by large cells (Anitschkow myocytes) and occasional multinucleated giant cells (Aschoff cells)






34. Different in that it is the primary disorder - recurrent vasospasm of small arteries and venules - pallor - cyanosis - fingers and toes - young healthy women






35. Aka lentigo maligna - precursor to lentigo maligna melanoma






36. DsDNA antibodies and Sm Smith antigen = highly specific for SLE






37. Development of large pituitary adenomas following bilat adrenalectomy






38. Hemihypertrophy - macroglossia - organomegaly - neonatal hypoglycemia - various embryonal tumors - deleted WT 2 gene






39. Thrombotic occlusion of major hepatic veins - abnormal pain - jaundice - hepatomegaly - acites - liver failure - assoc with polycythemia vera - hepatocellular CA - and other common neoplasms - may occur as a complication of pregnancy






40. Iron deficient anemia associated with upper::esophageal web






41. B Thalassemia major






42. Similar to paget breast - sometimes related to underlying adenoCA of sweat glands






43. Aka congenital megacolon - dilation of colon due to absence of ganglion cells






44. Follicular lymphoma IG heavy chain on 14 - bcl -2 oncogene on 18






45. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






46. Seen in Down synd - small white spots on periphery of iris






47. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






48. Aka allergic granulomatous angiitis - necrotizing vasculitis - variant of polyarteritis nodosa - involves pulmonary vasculature - peripheral eosinophilia - and asthma






49. B1 thiamine - B2 riboflavin - B3 niacin - B6 pyridoxine - B12 cobalamin - C ascorbic acid - D calciferol - E a::tocopherol






50. Thyroid replacement by fibrous tissue - unkown origin - mimics