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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Defective in x- linked brutons agammaglobulinemia - B- cell tyrosine kinase






2. Triad of ovarian fibroma - ascites - hydrothorax






3. = MEN1






4. Tumor suppressor mutated in breast and ovary






5. Tumor suppressor common in familial polyposis coli and adenoCA of colon as well as other tumors






6. Autoimmune hypothyroid - hurthle cells common






7. Gene product inhibits apoptosis






8. Intracytoplasmic inclusions seen in leydig cell tumors p283






9. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






10. Aka angiokeratoma corporis diffusum universal - deficient a::galactosidase A - accumulate ceramide trihexoside - skin lesions angiokeratomas - fever - burning pain in extremities - cardiovascular and cerebrovascular involvement - death as adult by re






11. Tumor suppressor mutated in wilms tumor






12. Intra::alveolar hemosiderin - laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN






13. Seen in insulinoma - episodic hyperinsulinemia and hypoglycemia - CNS dysfunction - reversal of CNS probs with administration of glucose






14. Downward displacement of cerebellar tonsils and medulla through foramen magnum






15. Epithelial cells with eosinophilc granular cytoplasm seen in hashimoto






16. Thiamine deficiency - cerebral dysfunction - aka alcoholic encephalopathy - hemorrhagic lesions in the mamillary bodies - confusion - ataxia - ophthalmoplegia - and memory loss plus confabulation p 105 and p115






17. Minute neutrophilic abscesses found within parakeratotic stratum corneum in psoriasis






18. Autosomal recessive - unusually large platelets - lack of 'GPIb IX V'






19. Aka trisomy 18 - mental retardation - prominent occiput - micrognathia (small jaw) - low::set ears - rocker::bottom feet - finger deformities - congenital heart dx






20. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






21. Hemangioblastoma or cavernous hemangioma of cerebellum - brainstem or retina - adenomas - cysts in liver - kidney - pancreas - and other organs - increased renal cell CA - gene = short arm of chromosome 3






22. This comes in a wet variety and a dry one - they are both Vit B1 thiamine deficiency






23. Aka pituitary cachexia - generalized panhypopituitarism






24. Aka osteitis deformans - increased osteoclastic and osteoblastic activity






25. Hereditary nephritis associated with nerve deafness and ocular disorders - mutation in gene for the a5 chain of type IV collagen






26. Primary aldosteronism






27. Gene product facilitates apoptosis






28. DsDNA antibodies and Sm Smith antigen = highly specific for SLE






29. Deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT) - low purine metabolism - high uric acid - thus gout - mental retardation - choreoathetosis - spasticity - self mutilation - aggressiveness






30. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






31. Eczematoid lesion of nipple areola - large cells with clear 'halo like' area - invade epidermis - underlying ductal CA






32. Binucleated or multinucleated giant cell seen in Hodgkin dx






33. Hereditary nonpolyposis colon cancer - DNA repair genes messed up






34. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3






35. B1 thiamine - B2 riboflavin - B3 niacin - B6 pyridoxine - B12 cobalamin - C ascorbic acid - D calciferol - E a::tocopherol






36. Aka infantile progressive spinal muscular atrophy - autosomal recessive - LMN disease - infants






37. Materal transmission del(15)(q11q13) - aka happy puppet syndrome - mental retardation - ataxia - seizures - inappropriate laughter






38. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






39. Port wine stain on face - ipsilateral glaucoma - vascular lesions of ocular choroidal tissue - extensive hemangiomatous involvement of meninges






40. Aka velocardiofacial syndrome and CATCH 22 syndrome - micro deletion of 22q11 - Cardiac abnormalities - Abnormal facies - T cell deficit due to thymic hypoplasia - Cleft palate - Hypocalcemia due to hypoparathyroidism - from poor development of 3rd a






41. Deficient hexosaminidase A - GM2 ganglioside accumulation - especially in neurons - CNS degeneration - mental/motor deterioration - blindness - cherry red spot on macula - death by 4 years of age






42. 2/neu :: oncogene (aka c - erbB2) - in breast cancer = poor prognosis






43. Hamartomatous polyps in colon and small intest - freckles on lips - hands - genitalia - higher incidence of adeno CA of colon and other malignancies - stomach - breast - ovaries






44. Burkitts c::myc is on 8 - IG heavy chain is on 14






45. Autosomal recessive - conj hyperbilirubinemia - defect in bili transport - black color to liver






46. Parkinsonism with autonomic dysfunction and orthostatic hypotension






47. Thrombotic occlusion of major hepatic veins - abnormal pain - jaundice - hepatomegaly - acites - liver failure - assoc with polycythemia vera - hepatocellular CA - and other common neoplasms - may occur as a complication of pregnancy






48. Non::neoplastic tumor like masses - fibrous replacement of resorbed bone






49. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






50. Pituitary insufficiency post - partum - low TSH ACTH