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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Scheinker syndrome :: prion dx - fatal familial insomnia






2. Aka hereditary hemorrhagic telangectasia - telangectasias in skin and mucous membranes - epistaxis - GI bleeds






3. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






4. Seen in urine of patients with multiple myeloma - Ig light chain either k or l






5. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






6. Mutation here causes pseudohypoparathyroidism






7. Gene mutated in achondroplasia (most common form of dwarfism) - located at 4p16.3






8. Deficient hexosaminidase A - GM2 ganglioside accumulation - especially in neurons - CNS degeneration - mental/motor deterioration - blindness - cherry red spot on macula - death by 4 years of age






9. Follicular lymphoma IG heavy chain on 14 - bcl -2 oncogene on 18






10. Retinoblastoma on chromosome 13






11. Chromosome 19 - allele common in alzheimers






12. Adenomatous polyps with tumors of CNS






13. Burkitts c::myc is on 8 - IG heavy chain is on 14






14. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






15. Aka congenital megacolon - dilation of colon due to absence of ganglion cells






16. Aka subcortical leukoencephalopathy - assoc with HTN - multiple lacunar infarcts and progressive demyelination in subcortical area






17. Tumor suppressor mutated in Von Recklinhousen






18. X linked - absence of plasma cells and serum immunoglobulins - cell mediated immunity still ok - no germinal centers - recurrent bacterial infections - resistances to fungal and viral still - btk gene defect






19. Nystagmus - intention tremor - scanning speech - seen in MS






20. Similar to Dubin Johnson with no black liver






21. DsDNA antibodies and Sm Smith antigen = highly specific for SLE






22. Minute neutrophilic abscesses found within parakeratotic stratum corneum in psoriasis






23. Severe unconj hyperbilirubinemia due to deficient glucuronyl transferase






24. Manifestation of lymphplasmocytic lymphoma - B cell neoplasm






25. Triad of ovarian fibroma - ascites - hydrothorax






26. B1 thiamine - B2 riboflavin - B3 niacin - B6 pyridoxine - B12 cobalamin - C ascorbic acid - D calciferol - E a::tocopherol






27. Associated with 90% cases of ankylosing spondylitis - common in rheumatoid arthritis






28. Aka mucocutaneous lymph node syndrome - acute self - limited - infants and young kids - acute necrotizing vasculitis of small and medium vessels - fever hemorrhagic edema of conjunctivae - lips and oral mucosa - and cervical LAD - can cause coronary






29. Tumor suppressor mutated in wilms tumor






30. Aka thromboangiitis obliterans - acute inflame of small and med arteries of extremities - extending to adjacent veins and nerves - young jewish men - painful ischemic dx - worse with smoking






31. 45 XO - female hypogonadism - hypothyroid - short - webbed neck - 1* amenorrhea p52






32. Radiologic appearance of periostium in bone tumors






33. Ring of copper deposited around iris seen in Wilson






34. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






35. Tumor suppressor mutated in breast and ovary






36. Nuclei arranged in horseshoe - shaped pattern about periphery of cell - characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)






37. Intracytoplasmic proximal dentritic eosinophilic inclusions consisting of actin seen in Alzheimers






38. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






39. Deficient glucose -6- phosphatase - accumulation of glycogen in liver and kidney - hepatomegaly - hypoglycemia






40. Protooncogene mutated in medulary thyroid CA (MENII)






41. B Thalassemia major






42. Similar to Hurler - deficient L iduronosulfate sulfatase - accumulations of heparin sulfate and dermatan sulfate - hepatospenomegaly - micrognathia - retinal degeneration - joint stiffness - mental retardation - cardiac lesions






43. Pigmented iris hamartoma seen in neurofibromatosis






44. At least 2 X and one Y - hypogonadism - tall - gynecomastia - low testosterone - high pituitary gonadotropins - infertility -






45. Deficient muscle phosphorylase - glycogen in skeletal muscle - cramps with exertion






46. Paternal transmission del (15)(q11q13) - hypogonad - hypotonia - mental retardation - behavior probs - uncrontrolled appetite






47. Paracentric inversion or translocation with 17 associated with papillary thyroid CA






48. Aka velocardiofacial syndrome and CATCH 22 syndrome - micro deletion of 22q11 - Cardiac abnormalities - Abnormal facies - T cell deficit due to thymic hypoplasia - Cleft palate - Hypocalcemia due to hypoparathyroidism - from poor development of 3rd a






49. Single erythematous plaque on shaft of penis or scrotum






50. Hereditary nephritis associated with nerve deafness and ocular disorders - mutation in gene for the a5 chain of type IV collagen