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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Minute neutrophilic abscesses found within parakeratotic stratum corneum in psoriasis






2. Area of focal interstitial myocardial inflammation characterized by fragmented collagen and fibrinoid material - by large cells (Anitschkow myocytes) and occasional multinucleated giant cells (Aschoff cells)






3. Hemangioblastoma or cavernous hemangioma of cerebellum - brainstem or retina - adenomas - cysts in liver - kidney - pancreas - and other organs - increased renal cell CA - gene = short arm of chromosome 3






4. Similar to paget breast - sometimes related to underlying adenoCA of sweat glands






5. Aka infantile progressive spinal muscular atrophy - autosomal recessive - LMN disease - infants






6. Chromosome 19 - allele common in alzheimers






7. Materal transmission del(15)(q11q13) - aka happy puppet syndrome - mental retardation - ataxia - seizures - inappropriate laughter






8. Tumor suppressor mutated in wilms tumor






9. Seen in CLL - leukemic B- cells that are fragile






10. Port wine stain on face - ipsilateral glaucoma - vascular lesions of ocular choroidal tissue - extensive hemangiomatous involvement of meninges






11. Seen in Down synd - small white spots on periphery of iris






12. Osteophytes at DIP joints






13. Variant of rheumatoid arthritis - splenmegally - neutropenia - RA






14. Autosomal dominant - fatal - progressive degeneration of striatum and frontal cortex with neuronal depletion and gliosis






15. Oncogenes that code for p21 proteins which are membrane signalers






16. Aggressive B- cell lymphoma - EBV - starry sky appearance - c myc






17. Nystagmus - intention tremor - scanning speech - seen in MS






18. Gene product facilitates apoptosis - decreases bcl::2 and increases Bax






19. = MEN2a






20. Aka chronic progressive histiocytosis - not as bad as Letterer Siwe






21. Deficient glucose -6- phosphatase - accumulation of glycogen in liver and kidney - hepatomegaly - hypoglycemia






22. X linked - aka immunodeficiency with thrombocytopenia and eczema - total immunoglobulins often normal - recurrent infections






23. B Thalassemia major






24. Autosomal recessive - hepatitis - accumulation of copper due to transport problem - low ceruloplasmin seen - kayser fleischer rings in eyes






25. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






26. = MEN1






27. 2/neu :: oncogene (aka c - erbB2) - in breast cancer = poor prognosis






28. Aka trisomy 13 - mental retardation - microcephaly - micropthalmia - brain abnormalities - cleft lip/palate - polydactyly - rockerbottom feet - congenital heart dx






29. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






30. Seen in urine of patients with multiple myeloma - Ig light chain either k or l






31. Thrombotic occlusion of major hepatic veins - abnormal pain - jaundice - hepatomegaly - acites - liver failure - assoc with polycythemia vera - hepatocellular CA - and other common neoplasms - may occur as a complication of pregnancy






32. Located on xsome 6 - mutation here = hereditary hemochromatosis






33. Aka mucocutaneous lymph node syndrome - acute self - limited - infants and young kids - acute necrotizing vasculitis of small and medium vessels - fever hemorrhagic edema of conjunctivae - lips and oral mucosa - and cervical LAD - can cause coronary






34. Seen in papillary thyroid CA






35. Catastrophic adrenal insuff and vascular collapse - hemorrhagic necrosis of adrenal cortex






36. Aka osteopetrosis - marble bone dx - dense skeleton - failure of osteoclastic activity






37. X linked - absence of plasma cells and serum immunoglobulins - cell mediated immunity still ok - no germinal centers - recurrent bacterial infections - resistances to fungal and viral still - btk gene defect






38. Intra::alveolar hemosiderin - laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN






39. Seen in insulinoma - episodic hyperinsulinemia and hypoglycemia - CNS dysfunction - reversal of CNS probs with administration of glucose






40. Sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver - spleen - lymph nodes and skin






41. Variant of rheumatoid arthritis - aka juvenile rheumatoid arthritis






42. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3






43. Abnormal WT 1 gene - intersexual disorders - nephropathy - wilms tumor






44. Esophageal diverticulum just above upper esoph sphincter






45. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






46. Superclavicular lymph node identifying metastatic stomach CA






47. Tumor suppressor mutated in Von Recklinhousen






48. Protooncogene mutated in medulary thyroid CA (MENII)






49. Aka subcortical leukoencephalopathy - assoc with HTN - multiple lacunar infarcts and progressive demyelination in subcortical area






50. Mutation here causes pseudohypoparathyroidism