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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Different in that it is the primary disorder - recurrent vasospasm of small arteries and venules - pallor - cyanosis - fingers and toes - young healthy women






2. Acute promyelocytic leukemia PML gene on 15 and RARa on 17






3. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)






4. Defective in x- linked brutons agammaglobulinemia - B- cell tyrosine kinase






5. Scheinker syndrome :: prion dx - fatal familial insomnia






6. Vasosmasm of small vessels - most often in fingers - seen with autoimmune dx like SLE - scleroderma and others (R in CREST) - recurrent vasospasm - always secondary to underlying disorder






7. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






8. 2/neu :: oncogene (aka c - erbB2) - in breast cancer = poor prognosis






9. Aka acute disseminated langerhans cell histiocytosis - aggressive - usually fatal - kids hepatosplenomegaly - LAD - pancytopenia - pulmonary involvement - recurrent infections






10. Located on xsome 6 - mutation here = hereditary hemochromatosis






11. Aka allergic granulomatous angiitis - necrotizing vasculitis - variant of polyarteritis nodosa - involves pulmonary vasculature - peripheral eosinophilia - and asthma






12. Associated with Wegener granulomatosis






13. Osteophytes at PIP joints






14. Tumor suppressor mutated in Von Recklinhousen






15. Thyroid replacement by fibrous tissue - unkown origin - mimics






16. Aka osteopetrosis - marble bone dx - dense skeleton - failure of osteoclastic activity






17. Hemangioblastoma or cavernous hemangioma of cerebellum - brainstem or retina - adenomas - cysts in liver - kidney - pancreas - and other organs - increased renal cell CA - gene = short arm of chromosome 3






18. Autosomal recessive - unusually large platelets - lack of 'GPIb IX V'






19. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






20. Thrombotic occlusion of major hepatic veins - abnormal pain - jaundice - hepatomegaly - acites - liver failure - assoc with polycythemia vera - hepatocellular CA - and other common neoplasms - may occur as a complication of pregnancy






21. Aka trisomy 18 - mental retardation - prominent occiput - micrognathia (small jaw) - low::set ears - rocker::bottom feet - finger deformities - congenital heart dx






22. Seen in hyperacute rejection - = acute inflammation - fibrinoid necrosis of small vessels - and extensive thrombosis






23. Myc :: neuroblastoma amplicatiion correlates inversely with degree of differentiation






24. Binucleated or multinucleated giant cell seen in Hodgkin dx






25. Mucinous cell - characteristic of stomach CA met to ovary (krukenberg tumor)






26. Nystagmus - intention tremor - scanning speech - seen in MS






27. Associated with breast alone (isn't one of these associated with prostate? Check)






28. Similar to paget breast - sometimes related to underlying adenoCA of sweat glands






29. Mutation here causes pseudohypoparathyroidism






30. Combination of hyperthyroidism - nodular goiter - absence of exophthalmos






31. Intracytoplasmic proximal dentritic eosinophilic inclusions consisting of actin seen in Alzheimers






32. Burkitts c::myc is on 8 - IG heavy chain is on 14






33. Area of focal interstitial myocardial inflammation characterized by fragmented collagen and fibrinoid material - by large cells (Anitschkow myocytes) and occasional multinucleated giant cells (Aschoff cells)






34. Aka congenital megacolon - dilation of colon due to absence of ganglion cells






35. Small round blue cell tumor of bone - long bones - kids - 11:22 transloc






36. Transloc seen in ewing sarcoma






37. Aka osteitis deformans - increased osteoclastic and osteoblastic activity






38. Esophageal diverticulum just above upper esoph sphincter






39. Dysplastic cell seen in HPV






40. Hereditary nephritis associated with nerve deafness and ocular disorders - mutation in gene for the a5 chain of type IV collagen






41. Deficient glucose -6- phosphatase - accumulation of glycogen in liver and kidney - hepatomegaly - hypoglycemia






42. Nuclei arranged in horseshoe - shaped pattern about periphery of cell - characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)






43. Also seen in urine of MM - stacks of RBCs - will have high ESR






44. Materal transmission del(15)(q11q13) - aka happy puppet syndrome - mental retardation - ataxia - seizures - inappropriate laughter






45. Primary adrenal failure






46. Protooncogene mutated in medulary thyroid CA (MENII)






47. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






48. Malignant lymphoma with features resembling inflammatory disorder - young men - Reed Sternburg cells






49. Tumor suppressor common in familial polyposis coli and adenoCA of colon as well as other tumors






50. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations