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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Aka hereditary hemorrhagic telangectasia - telangectasias in skin and mucous membranes - epistaxis - GI bleeds






2. Associated with 90% cases of ankylosing spondylitis - common in rheumatoid arthritis






3. Metastatic stomach CA to ovary






4. Mucinous cell - characteristic of stomach CA met to ovary (krukenberg tumor)






5. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






6. Similar to Dubin Johnson with no black liver






7. Mutation here causes pseudohypoparathyroidism






8. Deficient a1 -4 glucosidase - accumulation of glycogen in liver - heart - skeletal muscle - cardiomegaly - muscle hypotonia - spelnomegaly - intractable hypoglycemia - death from cardiorespiratory failure before age 3






9. Subcutaneous fibrosis of dorsum of penis






10. = MEN1






11. Eczematoid lesion of nipple areola - large cells with clear 'halo like' area - invade epidermis - underlying ductal CA






12. Autosomal recessive - unusually large platelets - lack of 'GPIb IX V'






13. Tumor suppressor mutated in Von Recklinhousen






14. Autoimmune hypothyroid - hurthle cells common






15. At least 2 X and one Y - hypogonadism - tall - gynecomastia - low testosterone - high pituitary gonadotropins - infertility -






16. Also seen in urine of MM - stacks of RBCs - will have high ESR






17. Malignant lymphoma with features resembling inflammatory disorder - young men - Reed Sternburg cells






18. Autosomal dominant - fatal - progressive degeneration of striatum and frontal cortex with neuronal depletion and gliosis






19. Nuclei arranged in horseshoe - shaped pattern about periphery of cell - characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)






20. Mucopolysaccharidosis - deficient a L iduronidase - accumulations of heparin sulfate and dermatan sulfate in heart - brain - liver - and other organs - progressive - hepatosplenomagaly - dwarfism - gargoyle - like facies - stubby fingers - corneal cl






21. Aka mucocutaneous lymph node syndrome - acute self - limited - infants and young kids - acute necrotizing vasculitis of small and medium vessels - fever hemorrhagic edema of conjunctivae - lips and oral mucosa - and cervical LAD - can cause coronary






22. Aka antiglomerular basement membrane dx - antibodies against alveolar and glomerular basement membranes - linear immunoflorescence






23. Paracentric inversion or translocation with 17 associated with papillary thyroid CA






24. Hereditary nephritis associated with nerve deafness and ocular disorders - mutation in gene for the a5 chain of type IV collagen






25. Aspirin toxicity seen in kids after acute febrile viral dx - microvesicular fatty change in liver and encephalopathy






26. Aka superior sulcus tumor - seen in bronchogenic CA - often with Horner's






27. Thiamine deficiency - cerebral dysfunction - aka alcoholic encephalopathy - hemorrhagic lesions in the mamillary bodies - confusion - ataxia - ophthalmoplegia - and memory loss plus confabulation p 105 and p115






28. Paraneoplastic synd looks like myasthenia gravis - often small cell lung CA






29. Gene mutated in achondroplasia (most common form of dwarfism) - located at 4p16.3






30. Hereditary nonpolyposis colon cancer - DNA repair genes messed up






31. 5p chromosome deletion - severe mental retardation - microcephaly - catlike cry - low birth weight - round face - hypertelorism (wide eyes)






32. Autoimmune thyroiditis - hyperthyroid - exophthalmos - increased in HLA DR3 and HLA B8 pos people






33. Deficient debranching enzyme amylo -1 -6- glucosidase - glycogen in liver - heart - skeletal muscle - stunted growth - hepatomegaly - hypoglycemia






34. Gene product facilitates apoptosis






35. Aka pulseless dx - inflammation and stenosis of medium and large sized arteries - often aortic arch thus aortic arch syndrome






36. Transloc seen in ewing sarcoma






37. Seen in CLL - leukemic B- cells that are fragile






38. Dysplastic cell seen in HPV






39. Tumor suppressor common in familial polyposis coli and adenoCA of colon as well as other tumors






40. Deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT) - low purine metabolism - high uric acid - thus gout - mental retardation - choreoathetosis - spasticity - self mutilation - aggressiveness






41. This comes in a wet variety and a dry one - they are both Vit B1 thiamine deficiency






42. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






43. Associated with Wegener granulomatosis






44. Aka chronic progressive histiocytosis - not as bad as Letterer Siwe






45. Aka IgA nephropathy - deposition of IgA in mesangium - benign recurrent hematuria in kids following infection






46. Defective cilia - sinusitis - bronchiectasis - situs inversus - sometimes hearing loss and male sterility






47. Single erythematous plaque on shaft of penis or scrotum






48. Modest elevated serum unconj bilirubin - due to decreased uptake by liver cells and reduced activity of glucuronyl transferase






49. Seen in papillary thyroid CA






50. Gene product facilitates apoptosis - decreases bcl::2 and increases Bax