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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. 45 XO - female hypogonadism - hypothyroid - short - webbed neck - 1* amenorrhea p52






2. Located on xsome 6 - mutation here = hereditary hemochromatosis






3. Esophageal diverticulum just above upper esoph sphincter






4. Gene product facilitates apoptosis - decreases bcl::2 and increases Bax






5. Mutation = paroxysmal nocturnal hemoglobinuria






6. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






7. Downward displacement of cerebellar tonsils and medulla through foramen magnum






8. = MEN2a






9. 5p chromosome deletion - severe mental retardation - microcephaly - catlike cry - low birth weight - round face - hypertelorism (wide eyes)






10. Protooncogene mutated in medulary thyroid CA (MENII)






11. Seen in hyperacute rejection - = acute inflammation - fibrinoid necrosis of small vessels - and extensive thrombosis






12. Paraneoplastic synd looks like myasthenia gravis - often small cell lung CA






13. Aka acute disseminated langerhans cell histiocytosis - aggressive - usually fatal - kids hepatosplenomegaly - LAD - pancytopenia - pulmonary involvement - recurrent infections






14. Variant of rheumatoid arthritis - splenmegally - neutropenia - RA






15. Aka subcortical leukoencephalopathy - assoc with HTN - multiple lacunar infarcts and progressive demyelination in subcortical area






16. X linked - aka immunodeficiency with thrombocytopenia and eczema - total immunoglobulins often normal - recurrent infections






17. Aspirin toxicity seen in kids after acute febrile viral dx - microvesicular fatty change in liver and encephalopathy






18. Tumor suppressor common in familial polyposis coli and adenoCA of colon as well as other tumors






19. Aka hereditary hemorrhagic telangectasia - telangectasias in skin and mucous membranes - epistaxis - GI bleeds






20. Nuclei arranged in horseshoe - shaped pattern about periphery of cell - characteristic of but not specific for granulomatous TB (as opposed to a foreign body giant cell that has scattered nuclei)






21. Dysplastic cell seen in HPV






22. Clear cell renal tumor seen in kids






23. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)






24. Hamartomatous polyps in colon and small intest - freckles on lips - hands - genitalia - higher incidence of adeno CA of colon and other malignancies - stomach - breast - ovaries






25. Subcutaneous fibrosis of dorsum of penis






26. Associated with breast alone (isn't one of these associated with prostate? Check)






27. Aka velocardiofacial syndrome and CATCH 22 syndrome - micro deletion of 22q11 - Cardiac abnormalities - Abnormal facies - T cell deficit due to thymic hypoplasia - Cleft palate - Hypocalcemia due to hypoparathyroidism - from poor development of 3rd a






28. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






29. Also seen in urine of MM - stacks of RBCs - will have high ESR






30. Materal transmission del(15)(q11q13) - aka happy puppet syndrome - mental retardation - ataxia - seizures - inappropriate laughter






31. Appears as multiple wart - like lesions resembling condyloma accuminatum






32. Philadelphia chromosome - CML bcr abl fusion c - abl on 9 - bcr on 22






33. Tumor suppressor mutated in wilms tumor






34. Hemihypertrophy - macroglossia - organomegaly - neonatal hypoglycemia - various embryonal tumors - deleted WT 2 gene






35. Severe unconj hyperbilirubinemia due to deficient glucuronyl transferase






36. Parkinsonism with autonomic dysfunction and orthostatic hypotension






37. X linked - absence of plasma cells and serum immunoglobulins - cell mediated immunity still ok - no germinal centers - recurrent bacterial infections - resistances to fungal and viral still - btk gene defect






38. Transloc seen in ewing sarcoma






39. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






40. 2/neu :: oncogene (aka c - erbB2) - in breast cancer = poor prognosis






41. Aka antiglomerular basement membrane dx - antibodies against alveolar and glomerular basement membranes - linear immunoflorescence






42. Pituitary insufficiency post - partum - low TSH ACTH






43. Intracytoplasmic proximal dentritic eosinophilic inclusions consisting of actin seen in Alzheimers






44. Port wine stain on face - ipsilateral glaucoma - vascular lesions of ocular choroidal tissue - extensive hemangiomatous involvement of meninges






45. Paternal transmission del (15)(q11q13) - hypogonad - hypotonia - mental retardation - behavior probs - uncrontrolled appetite






46. Aka superior sulcus tumor - seen in bronchogenic CA - often with Horner's






47. Binucleated or multinucleated giant cell seen in Hodgkin dx






48. Diffuse nodular diabetic glomerulosclerosis






49. Superclavicular lymph node identifying metastatic stomach CA






50. Thyroid replacement by fibrous tissue - unkown origin - mimics