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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Oncogenes that code for p21 proteins which are membrane signalers






2. Abnormal WT 1 gene - intersexual disorders - nephropathy - wilms tumor






3. Autosomal dominant - fatal - progressive degeneration of striatum and frontal cortex with neuronal depletion and gliosis






4. Intra::alveolar hemosiderin - laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN






5. Malabsorption syndrome - Tropheryma wippelii bacilli - small intestine commonly affected - arthralgias - cardiac - and neuro symptoms






6. Paracentric inversion or translocation with 17 associated with papillary thyroid CA






7. Superclavicular lymph node identifying metastatic stomach CA






8. Aka trisomy 18 - mental retardation - prominent occiput - micrognathia (small jaw) - low::set ears - rocker::bottom feet - finger deformities - congenital heart dx






9. Scheinker syndrome :: prion dx - fatal familial insomnia






10. Sphingomyelin containing phagocytes seen in Niemman::Pick dx in liver - spleen - lymph nodes and skin






11. Aspirin toxicity seen in kids after acute febrile viral dx - microvesicular fatty change in liver and encephalopathy






12. Associated with Wegener granulomatosis






13. Aka lentigo maligna - precursor to lentigo maligna melanoma






14. Seen in hyperacute rejection - = acute inflammation - fibrinoid necrosis of small vessels - and extensive thrombosis






15. Osteophytes at PIP joints






16. Transloc seen in ewing sarcoma






17. Eosinophilic intracytoplasmic inclusions in hippocampus and purkinje cells seen in rabies infection






18. X linked - aka immunodeficiency with thrombocytopenia and eczema - total immunoglobulins often normal - recurrent infections






19. Primary aldosteronism






20. Osteophytes at DIP joints






21. Defective in x- linked brutons agammaglobulinemia - B- cell tyrosine kinase






22. Vaginal epithelial cell with stippled appearance due to adherent coccobacilli






23. Metastatic stomach CA to ovary






24. Severe unconj hyperbilirubinemia due to deficient glucuronyl transferase






25. Aka acute disseminated langerhans cell histiocytosis - aggressive - usually fatal - kids hepatosplenomegaly - LAD - pancytopenia - pulmonary involvement - recurrent infections






26. Deficient glucocerebrosidase - accumulation of glucocerebroside in cells of mononuclear phagocyte system 3 types ::






27. Aka polycystic ovary syndrome - young women - amenorrhea - infertility - obesity - hirsutism






28. Intracytoplasmic inclusions seen in leydig cell tumors p283






29. 5p chromosome deletion - severe mental retardation - microcephaly - catlike cry - low birth weight - round face - hypertelorism (wide eyes)






30. Autosomal recessive - unusually large platelets - lack of 'GPIb IX V'






31. Seen in CLL - leukemic B- cells that are fragile






32. Eczematoid lesion of nipple areola - large cells with clear 'halo like' area - invade epidermis - underlying ductal CA






33. Parkinsonism with autonomic dysfunction and orthostatic hypotension






34. Aka pituitary cachexia - generalized panhypopituitarism






35. Primary adrenal failure






36. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






37. Aneurysm at small artery bifurcations






38. Similar to Hurler - deficient L iduronosulfate sulfatase - accumulations of heparin sulfate and dermatan sulfate - hepatospenomegaly - micrognathia - retinal degeneration - joint stiffness - mental retardation - cardiac lesions






39. Variant of rheumatoid arthritis - splenmegally - neutropenia - RA






40. Aka neurofibromatosis - neurofibromas in skin - schwannomas of CN VIII - caf






41. Deficient sphingomyelinase - accumulation of sphingomyelin in phagocytes - foamy histiocytes in liver - spleen - lymph nodes - skin - hepatosplenomegaly - anemia fever - occasional neuro degeneration - half have cherry red spot macula






42. Gene product facilitates apoptosis






43. Seen in granuloma inguinale - multiple organisms filling large histiocytes






44. X linked - absence of plasma cells and serum immunoglobulins - cell mediated immunity still ok - no germinal centers - recurrent bacterial infections - resistances to fungal and viral still - btk gene defect






45. Intracytoplasmic proximal dentritic eosinophilic inclusions consisting of actin seen in Alzheimers






46. Thyroid replacement by fibrous tissue - unkown origin - mimics






47. Gene mutated in achondroplasia (most common form of dwarfism) - located at 4p16.3






48. Paraneoplastic synd looks like myasthenia gravis - often small cell lung CA






49. Variant of rheumatoid arthritis - aka juvenile rheumatoid arthritis






50. Hereditary nephritis associated with nerve deafness and ocular disorders - mutation in gene for the a5 chain of type IV collagen