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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Acute promyelocytic leukemia PML gene on 15 and RARa on 17






2. Hamartomatous polyps in colon and small intest - freckles on lips - hands - genitalia - higher incidence of adeno CA of colon and other malignancies - stomach - breast - ovaries






3. Mutation here causes pseudohypoparathyroidism






4. Defective in x- linked brutons agammaglobulinemia - B- cell tyrosine kinase






5. Small round eosinophilic masses found in dieing hepatocytes often containing chromatin remnants seen in viral hepatitis






6. X linked - absence of plasma cells and serum immunoglobulins - cell mediated immunity still ok - no germinal centers - recurrent bacterial infections - resistances to fungal and viral still - btk gene defect






7. Deficient fibrillin (constituent of microfibrils) - arachnodactyly - ectopia lentis - aortic aneurysm - mitral valve prolapsed






8. Vasosmasm of small vessels - most often in fingers - seen with autoimmune dx like SLE - scleroderma and others (R in CREST) - recurrent vasospasm - always secondary to underlying disorder






9. Aka osteopetrosis - marble bone dx - dense skeleton - failure of osteoclastic activity






10. Deficient debranching enzyme amylo -1 -6- glucosidase - glycogen in liver - heart - skeletal muscle - stunted growth - hepatomegaly - hypoglycemia






11. B Thalassemia major






12. Aneurysm at small artery bifurcations






13. Gene product facilitates apoptosis






14. Scheinker syndrome :: prion dx - fatal familial insomnia






15. Triad of ovarian fibroma - ascites - hydrothorax






16. This comes in a wet variety and a dry one - they are both Vit B1 thiamine deficiency






17. Located on xsome 6 - mutation here = hereditary hemochromatosis






18. Superclavicular lymph node identifying metastatic stomach CA






19. Aka acute disseminated langerhans cell histiocytosis - aggressive - usually fatal - kids hepatosplenomegaly - LAD - pancytopenia - pulmonary involvement - recurrent infections






20. Infectious disorder - caused postencephalitic parkinsonism






21. Aggressive B- cell lymphoma - EBV - starry sky appearance - c myc






22. Intra::alveolar hemosiderin - laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN






23. Autosomal dominant - numerous adenomatous polyps along with osteomas and soft tissue tumors






24. Deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT) - low purine metabolism - high uric acid - thus gout - mental retardation - choreoathetosis - spasticity - self mutilation - aggressiveness






25. Iron deficient anemia associated with upper::esophageal web






26. Metastatic stomach CA to ovary






27. Seen in hyperacute rejection - = acute inflammation - fibrinoid necrosis of small vessels - and extensive thrombosis






28. = MEN1






29. Modest elevated serum unconj bilirubin - due to decreased uptake by liver cells and reduced activity of glucuronyl transferase






30. DsDNA antibodies and Sm Smith antigen = highly specific for SLE






31. Tumor suppressor common in familial polyposis coli and adenoCA of colon as well as other tumors






32. Aka thromboangiitis obliterans - acute inflame of small and med arteries of extremities - extending to adjacent veins and nerves - young jewish men - painful ischemic dx - worse with smoking






33. Aka trisomy 13 - mental retardation - microcephaly - micropthalmia - brain abnormalities - cleft lip/palate - polydactyly - rockerbottom feet - congenital heart dx






34. Seen in Down synd - small white spots on periphery of iris






35. Aka antiglomerular basement membrane dx - antibodies against alveolar and glomerular basement membranes - linear immunoflorescence






36. Aka polycystic ovary syndrome - young women - amenorrhea - infertility - obesity - hirsutism






37. Deficient muscle phosphorylase - glycogen in skeletal muscle - cramps with exertion






38. Hereditary nonpolyposis colon cancer - DNA repair genes messed up






39. Nystagmus - intention tremor - scanning speech - seen in MS






40. Autosomal dominant - fatal - progressive degeneration of striatum and frontal cortex with neuronal depletion and gliosis






41. Unknown etiology - necrotizing granulomatous vasculitis of small to medium sized vessels of the respiratory tract - kidneys - and other organs - circulating C- ANCAs






42. Appears as multiple wart - like lesions resembling condyloma accuminatum






43. Osteophytes at DIP joints






44. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






45. Hemangioblastoma or cavernous hemangioma of cerebellum - brainstem or retina - adenomas - cysts in liver - kidney - pancreas - and other organs - increased renal cell CA - gene = short arm of chromosome 3






46. Aka osteitis deformans - increased osteoclastic and osteoblastic activity






47. Gene product facilitates apoptosis - decreases bcl::2 and increases Bax






48. Aka allergic granulomatous angiitis - necrotizing vasculitis - variant of polyarteritis nodosa - involves pulmonary vasculature - peripheral eosinophilia - and asthma






49. Deficient glucocerebrosidase - accumulation of glucocerebroside in cells of mononuclear phagocyte system 3 types ::






50. Autoimmune hypothyroid - hurthle cells common






Can you answer 50 questions in 15 minutes?



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