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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Paternal transmission del (15)(q11q13) - hypogonad - hypotonia - mental retardation - behavior probs - uncrontrolled appetite






2. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






3. Deficient muscle phosphorylase - glycogen in skeletal muscle - cramps with exertion






4. Mutation = paroxysmal nocturnal hemoglobinuria






5. On lymph node biopsy - seen with Burkitt lymphoma






6. Similar to Hurler - deficient L iduronosulfate sulfatase - accumulations of heparin sulfate and dermatan sulfate - hepatospenomegaly - micrognathia - retinal degeneration - joint stiffness - mental retardation - cardiac lesions






7. Aka thromboangiitis obliterans - acute inflame of small and med arteries of extremities - extending to adjacent veins and nerves - young jewish men - painful ischemic dx - worse with smoking






8. Non::neoplastic tumor like masses - fibrous replacement of resorbed bone






9. Autoimmune hypothyroid - hurthle cells common






10. Tumor suppressor mutated in Von Recklinhousen






11. Aneurysm at small artery bifurcations






12. This comes in a wet variety and a dry one - they are both Vit B1 thiamine deficiency






13. Peripheral neuropathy - atrophy of muscles - wet - high output cardiac failure - DCM - AV shunting - hypervolemia






14. Seen in papillary thyroid CA






15. Polyostotic fibrous dysplasia - precocious puberty - caf






16. Aka acute disseminated langerhans cell histiocytosis - aggressive - usually fatal - kids hepatosplenomegaly - LAD - pancytopenia - pulmonary involvement - recurrent infections






17. Abnormal WT 1 gene - intersexual disorders - nephropathy - wilms tumor






18. Catastrophic adrenal insuff and vascular collapse - hemorrhagic necrosis of adrenal cortex






19. Epithelial cells with eosinophilc granular cytoplasm seen in hashimoto






20. Chromosome 19 - allele common in alzheimers






21. Seen in CLL - leukemic B- cells that are fragile






22. Deficient fibrillin (constituent of microfibrils) - arachnodactyly - ectopia lentis - aortic aneurysm - mitral valve prolapsed






23. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






24. Iron deficient anemia associated with upper::esophageal web






25. Manifestation of lymphplasmocytic lymphoma - B cell neoplasm






26. Aka superior sulcus tumor - seen in bronchogenic CA - often with Horner's






27. Aka angiokeratoma corporis diffusum universal - deficient a::galactosidase A - accumulate ceramide trihexoside - skin lesions angiokeratomas - fever - burning pain in extremities - cardiovascular and cerebrovascular involvement - death as adult by re






28. X linked - aka immunodeficiency with thrombocytopenia and eczema - total immunoglobulins often normal - recurrent infections






29. Renal tubular dysfunction - impaired reabsorption of glucose - amino acids - phosphate - and bicarb thus glycosuria - hyperphosphaturia - hypophosphatemia - aminoaciduria - systemic acidosis






30. Paracentric inversion or translocation with 17 associated with papillary thyroid CA






31. Aka allergic granulomatous angiitis - necrotizing vasculitis - variant of polyarteritis nodosa - involves pulmonary vasculature - peripheral eosinophilia - and asthma






32. Small follicles filled with eosinophilic secretion - diagnostic feature of granulose cell tumor






33. Single erythematous plaque on shaft of penis or scrotum






34. Hamartomatous polyps in colon and small intest - freckles on lips - hands - genitalia - higher incidence of adeno CA of colon and other malignancies - stomach - breast - ovaries






35. Gene product facilitates apoptosis






36. Aka antiglomerular basement membrane dx - antibodies against alveolar and glomerular basement membranes - linear immunoflorescence






37. Mucopolysaccharidosis - deficient a L iduronidase - accumulations of heparin sulfate and dermatan sulfate in heart - brain - liver - and other organs - progressive - hepatosplenomagaly - dwarfism - gargoyle - like facies - stubby fingers - corneal cl






38. Aka osteitis deformans - increased osteoclastic and osteoblastic activity






39. Seen in granuloma inguinale - multiple organisms filling large histiocytes






40. Autosomal recessive - neutropenia - albinism - cranial and peripheral neuropathy - tendency to develop repeated infections - abnormal WBCs (abnormal mictotubul formation and large cytoplasmic granules = lysosomes)






41. Hereditary nephritis associated with nerve deafness and ocular disorders - mutation in gene for the a5 chain of type IV collagen






42. Downward displacement of cerebellar tonsils and medulla through foramen magnum






43. Deficient glucocerebrosidase - accumulation of glucocerebroside in cells of mononuclear phagocyte system 3 types ::






44. Aka osteopetrosis - marble bone dx - dense skeleton - failure of osteoclastic activity






45. Seen in hyperacute rejection - = acute inflammation - fibrinoid necrosis of small vessels - and extensive thrombosis






46. Eczematoid lesion of nipple areola - large cells with clear 'halo like' area - invade epidermis - underlying ductal CA






47. 45 XO - female hypogonadism - hypothyroid - short - webbed neck - 1* amenorrhea p52






48. Metastatic stomach CA to ovary






49. Occurs in SLE - small vegitations on either or both surfaces of valves






50. = MEN2a







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