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USMLE Brs Pathology Vocab

Subjects : health-sciences, usmle
Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. 45 XO - female hypogonadism - hypothyroid - short - webbed neck - 1* amenorrhea p52






2. Lots of tumors - breast CA - soft tissue sarc - brain tumors - leukemias - has loss of p53 tumor suppressor gene






3. Acute promyelocytic leukemia PML gene on 15 and RARa on 17






4. Thyroid replacement by fibrous tissue - unkown origin - mimics






5. Adenomatous polyps with tumors of CNS






6. Aka subcortical leukoencephalopathy - assoc with HTN - multiple lacunar infarcts and progressive demyelination in subcortical area






7. Seen in granuloma inguinale - multiple organisms filling large histiocytes






8. Tumor suppressor mutated in wilms tumor






9. Eosinophilic intracytoplasmic inclusions in hippocampus and purkinje cells seen in rabies infection






10. Hemihypertrophy - macroglossia - organomegaly - neonatal hypoglycemia - various embryonal tumors - deleted WT 2 gene






11. Asbestosis - yellow - brown - rod shaped body with clubbed ends - stain with Prussian blue






12. Paracentric inversion or translocation with 17 associated with papillary thyroid CA






13. Chromosome 19 - allele common in alzheimers






14. Tennis racket shaped cytoplasmic inclusion seen in langerhans cells (so also seen in langerhan cell histiocytosis)






15. Tumor suppressor common in familial polyposis coli and adenoCA of colon as well as other tumors






16. Burkitts c::myc is on 8 - IG heavy chain is on 14






17. Ring of copper deposited around iris seen in Wilson






18. Deficient hexosaminidase A - GM2 ganglioside accumulation - especially in neurons - CNS degeneration - mental/motor deterioration - blindness - cherry red spot on macula - death by 4 years of age






19. Aggressive B- cell lymphoma - EBV - starry sky appearance - c myc






20. Protooncogene mutated in medulary thyroid CA (MENII)






21. Gene product facilitates apoptosis - decreases bcl::2 and increases Bax






22. Mesangial matrix material acculmulations seen in nodular glomerulosclerosis seen in diabetic nephropathy






23. Aka pituitary cachexia - generalized panhypopituitarism






24. Deficient debranching enzyme amylo -1 -6- glucosidase - glycogen in liver - heart - skeletal muscle - stunted growth - hepatomegaly - hypoglycemia






25. This comes in a wet variety and a dry one - they are both Vit B1 thiamine deficiency






26. Aneurysm at small artery bifurcations






27. Gene product facilitates apoptosis






28. Intracytoplasmic proximal dentritic eosinophilic inclusions consisting of actin seen in Alzheimers






29. Similar to Dubin Johnson with no black liver






30. Subcutaneous fibrosis of dorsum of penis






31. Single erythematous plaque on shaft of penis or scrotum






32. Oligohydramnios causes fetus to be smashed






33. Osteophytes at DIP joints






34. Located on xsome 6 - mutation here = hereditary hemochromatosis






35. Deficient fibrillin (constituent of microfibrils) - arachnodactyly - ectopia lentis - aortic aneurysm - mitral valve prolapsed






36. Similar to paget breast - sometimes related to underlying adenoCA of sweat glands






37. Hemangioblastoma or cavernous hemangioma of cerebellum - brainstem or retina - adenomas - cysts in liver - kidney - pancreas - and other organs - increased renal cell CA - gene = short arm of chromosome 3






38. = MEN2a






39. Aka infantile progressive spinal muscular atrophy - autosomal recessive - LMN disease - infants






40. Associated with breast alone (isn't one of these associated with prostate? Check)






41. Parkinsonism with autonomic dysfunction and orthostatic hypotension






42. Associated with papillary thyroid CA






43. Hemorrhagic urticaria of extensor surgaces of arms - legs - and buttocks - with fever - arthralgias - and GI renal involvement similar to IgA nephropathy - associated with URIs






44. Aspirin toxicity seen in kids after acute febrile viral dx - microvesicular fatty change in liver and encephalopathy






45. Intra::alveolar hemosiderin - laden macrophages caused by RBCs from capillary rupture 2* to pulmonary HTN






46. Impaired tubular reabsorption of tryptophan - pellagra::like manifestations






47. Deficient hypoxanthine::guanine phosphoribosyltransferase (HGPRT) - low purine metabolism - high uric acid - thus gout - mental retardation - choreoathetosis - spasticity - self mutilation - aggressiveness






48. DsDNA antibodies and Sm Smith antigen = highly specific for SLE






49. Seen in papillary thyroid CA






50. X linked - absence of plasma cells and serum immunoglobulins - cell mediated immunity still ok - no germinal centers - recurrent bacterial infections - resistances to fungal and viral still - btk gene defect