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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug used for N. gonorrhea in females
Streptomycin
Ceftriaxone
Aldehyde dehydrogenase
sodium polystyrene sulfonate (Kayexalate)
2. Sedation is a common side effect of these drugs - they lower seizure threshold - uses include BAD - acute panic attacks - phobias - enuresis - and chronic pain and their overdose can be deadly
Diphenhydramine and cimetridine - respectively
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Tricyclic antidepressants (TCA)
Haloperidol
3. SE of hydroxychloroquine
Retinal destruction and dermatitis
Overdose of opioids
Inhibit dihydropteroate synthase
Diazepam
4. Major SE of bisphosphonates
Lorazepam - oxazepam - and temazepam
Drug induced Parkinsonism
Chemical esophagitis
Stevens - Johnson syndrome
5. Primary endogenous substrate for Nitric Oxidase Synthase
Mechlorethamine
Arginine
Albuterol
Fluoxetine (Sarafem)
6. Drug ofter used in combination with TNF - alpha inhitors for RA
Methotrexate
Succinylcholine
Somatostatin
Mirtazapine
7. DOC for malignant hyperthermia by acting on the sacroplasmic reticulum or skeletal muscle
LSD
Atracurium
Dantrolene
Neuromuscular blocking drugs
8. Newer estrogen receptor antagonist used in advanced breast cancer
Metronidazole
Toremifene (Fareston)
Interleukin 11 (oprelvekin)
First order kinetics
9. Antiarrhythmic that exhibits Class II and III properties
Dextromethorphan - Codeine
Sotalol
Blocks peptidoglycan synthesis
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
10. DOC for tx of pseudomembranous colitis
Metronidazole
Acyclovir; incorporated into viral DNA and chain termination
Pilocarpine - carbachol - physostigmine
Succinylcholine
11. Concentration in the plasma times (clearance divided by bioavailability)
Acarbose
Thioamides - iodides - radioactive iodine - and ipodate
Maintenance dose (Cp*(CL/F))
Ethanol - fomepizole
12. Orthostatic hypotension and QT prolongation
Physostigmine
CNS toxicity
Haloperidol
Low potency phenothiazines and ziprasidone
13. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease
Spasmolytic drugs
Suramin
5-7 days
Raloxifene
14. Antidote for hyperkalemia
sodium polystyrene sulfonate (Kayexalate)
Monamine oxidase inhibitors
Acebutolol - atenolol - esmolol - metoprolol
Protamine sulfate
15. Beta 2 agonist toxicity
Didanosine
Skeletal muscle tremor - tachycardia
Haloperidol
N- acetylcysteine (Mucomyst)
16. Lactam that can be used in PCN allergic patients
Cartilage damage
Heparin induced thrombocytopenia (HIT)
Sumatriptan - naratriptan - and rizatriptan
Aztreonam
17. Inhaled anesthetic causes peripheral vasodilation
Isoflurane
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Carbamazepine
Increase the DURATION of GABA- mediated chloride ion channels
18. Beta blockers work in CHF by
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Dicyclomine - methscopolamine
Reducing progression of heart failure (never use in acute heart failure)
Scopolamine - meclizine
19. Cephalosporin causes kernicterus in neonates
Oral
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Neutropenia and agranulocytosis
Ceftriaxone or cefuroxime
20. Meglitinide class of drugs
Repaglinide
Propofol
Reduce aqueous secretion
Baclofen
21. Contraindications to use of atropine
Timolol
Somatrem
Fluoxetine
Infants - closed angle glaucoma - prostatic hypertrophy
22. Agents that block L- type calcium channel
Metronidazole
GLUT 2
Pindolol and acebutolol
Calcium channel blockers
23. Agents that reduce heart rate - contractility - and O2 demand
Point mutation
Bradykinin
Beta - blockers
Diphenoxylate - Loperamide
24. Anti - psychotics available in depot preparation
Diazepam
Ganciclovir - zidovudine - saquinavir - and interferon
Maintenance dose (Cp*(CL/F))
Fluphenazine and haloperidol
25. Aspirin reduces mortality in unstable angina by
Cyclobenzaprine
Suramin
Urinary acidification and activated charcoal or continual nasogastric suction
Platelet aggregation inhibition
26. Antidote used for cyanide poisoning
Nitrites
SSRIs
Cocaine
Aspirin
27. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Metronidazole
Muscarinic blockers
Clonazepam
Elderly patients
28. Allopurinol treats chronic gout by decreasing uric acid production by inhibiting
B- blockers
Nifedipine
Xanthine oxidase
Infliximab
29. Antidote used for beta agonist toxicity (eg. Metaproterenol)
Arginine
Bethanechol
CNS stimulation; GI upset
Esmolol
30. Agents used in treatment of carcinoid tumor
Dopamine
Ketanserin cyproheptadine - and phenoxybenzamine
Tolerance
Propranolol
31. Vancomycin MOA
Glucagon
Blocks peptidoglycan synthesis
Nefazodone
Beta blockers
32. Good hypnotic activity with less CNS SE than most benzodiazepines
Pramipexole and ropinirole
Zolpidem - zaleplon
Thyroxine
Kidneys
33. Peakless ling acting insulin
Propranolol
Insulin glargine
Side - effect profile and prior pt response
Ethanol - Barbiturates - and Benzodiazepines
34. Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
ACE inhibitors
Diazepam
Bethanechol
Didanosine
35. Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release
Apraclonidine - brimonidine
Tinnitus - GI bleeding
Presynaptic mu - delta - and kappa receptors
Inhibit Cytochrome P450 3A4
36. Diuretic used to treat primary aldosteronism
Thiopental
Dimercaprol - EDTA
lispro insulin - aspart insulin - glulisine insulin
Spironolactone
37. Benzodiazepines that are the most effective in the treatment of panic disorder
Cytomel
Glucagon
Alprazolam and Clonazepam
Cutaneous flush
38. Antiestrogen drugs used for fertility and breast cancer respectively
Clomiphene and tamoxifen
inhibits HMG COA reductase
Maintenance dose (Cp*(CL/F))
Phenoxybenzamine
39. Common mechanism by which overdose result in death
Depression of medullary and cardiovascular centers
Bone marrow and teeth discoloration for children under 8 years of age
Cytomel
Paclitaxel (taxol)
40. Side effects frequently seen with SSRIs
Sulfonamides
Cholinesterase inhibitors
CNS stimulation; GI upset
Adenosine
41. SE of CCB
Rheumatic disease
Tamsulosin
Constipation - edema - and headache
Pregnancy
42. Initial DMARD of choice for patients with RA
Acute intermittent porphyria
Hydroxychloroquine
Methotrexate
Insulin release from pancreas; faster and shorter acting than sulfonylurea
43. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation
Fluorocarbons and Industrial solvents
Dolasetron
Metronidazole
Alpha1 agonists
44. Atropine fever is the most dangerous effect and can be lethal in this population group
Ethinyl estradiol and mestranol
Insulin
Infants
Vancomycin
45. MOA of AGI's
Pregnancy
Testosterone
Amphetamines
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
46. '5HT-1d agonist used for migraine headaches '
Bupropion
Toremifene (Fareston)
Sumatriptan - naratriptan - and rizatriptan
Aspirin irreversibly inhibits cyclooxygenase
47. Life threatening cardiac event that prolong QT leads to
Torsades de pointes
Physostigmine
Zero order kinetics
Nondepolarizing type antagonists
48. Antiglaucoma organophosphate
Overdose of opioids
Carboplatin
Echothiophate
Cerebral hemorrhage
49. MAOI should not be administered with SSRI's or potent TCA's due to development of this condition
PCP
Chlorpropamide
Serotonin syndrome
Estogens increase maternal TBG
50. Antidote for tissue plasminogen activator (t - PA) - streptokinase
Ethinyl estradiol and mestranol
Entacapone and Tolcapone
Aminocaproic acid
Acyclovir; incorporated into viral DNA and chain termination