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USMLE/COMLEX Step 1 Pharmacology One Liners
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Subjects
:
health-sciences
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usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
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study here
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Benzodiazepine that is used for anesthesia
SEVERE myelosuppression
Midazolam
Chlorpropamide
Leuprolide
2. Antidote for acetaminophen toxicity
N- acetylcysteine
Indomethacin
L- thyroxine (T4)
Zileuton
3. MOA of nystatin
Lorazepam - oxazepam - and temazepam
Bind ergosterol in fungal cell membrane
Delavirdine - efavirenz - and ribavirin
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
4. Ergot alkaloid used as an illicit drug
Aspirin irreversibly inhibits cyclooxygenase
Benztropine - trihexyphenidyl
LSD
First order kinetics
5. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
Selegiline
Ribavirin
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Muscarinic blockers
6. Monitoring parameter to obtain before initiation of STATINS
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7. Lithium is associated with this congenital defect
Cardiac anomalies and is contraindicated in pregnancy or lactation
Oral and transdermal forms of nitroglycerin
Digoxin
Irreversibly blocking cyclooxygenase
8. 1st generation antihistamine that is highly sedating
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Sedation
Diphendydramine
Morphine - methadone - meperidine - and fentanyl
9. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure
Venlafaxine
Epinephrine
Disulfiram
Nonselective Muscarinic Antagonists
10. Treatment of resistant pseudomembranous colitis
Raloxifene (SERM- selective estrogen receptor modulator)
ORAL vancomycin
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
11. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction
Use in IgE mediated allergic reaction
Meperidine
Thick ascending limb
Diazepam
12. Aminoglycoside that is least ototoxic
Nitrous oxide
Lactic acidosis
Streptomycin
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
13. Drugs available in combination with metformin
Iron deiodinates thyroxine
Half - life (T1/2)
Temazpam - trizolam - flurazepam
Glyburide - glipizide - and rosiglitazone
14. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Opioid Analgesics
Cartilage damage
Ketamine
Methotrexate
15. Pungent inhaled anesthetic which leads to high incidence of coughing and vasospasm
Dopamine blockade
Desflurane
Bleeding
Clomipramine
16. Agent with zero - order kinetics
Prednisone
Midazolam
Methotrexate
Ethanol
17. SE of minoxidil
inhibits Na+/K+/2Cl - cotransport
Carboplatin
Atropine - homatropine - C1208 tropicamide
Hypertrichosis
18. Treatment of motion sickness
Reducing preload
Scopolamine - meclizine
Ability to cross the placenta
Uterine contractions
19. SSRI indicated for premenstrual dysphoric disorder
Nortriptyline - Desipramine
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
LD50
Fluoxetine (Sarafem)
20. Most important potential SE of metformin
Cisplatin
Ganciclovir - zidovudine - saquinavir - and interferon
Esmolol
Lactic acidosis
21. MOA for Ethosuximide
Finasteride (Proscar and Propecia respectively)
Neostigmine
Calcium channels
Pindolol and acebutolol
22. Treatment for TB patients (think RIPE)
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Amoxapine
Letrozole - anastrozole
23. Difference between COX 1 and COX 2
High therapeutic index
Zileuton
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
24. Acetaminophen only has
Tinnitus - GI bleeding
Antipyretic and analgesic activity
Adalimumab - infliximab and etanercept
Glucuronate - acetic acid - and glutathione sulfate
25. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Adenosine
Finasteride (Proscar and Propecia respectively)
Haloperidol
26. Examples of alpha - glucosidase inhibitors (AGI)
Radioactive iodine
Spironolactone
Acarbose - miglitol
Potency
27. Drugs used in the management of angina
Aspirin - Nitrates - CCB - and Beta blockers
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Midazolam
Clearance (CL)
28. Sedative - Hypnotics action
Ketanserin cyproheptadine - and phenoxybenzamine
Nefazodone
Sodium channel blockers
Reduce inhibition - suppress anxiety - and produce relaxation
29. Diuretic used to treat primary aldosteronism
Spironolactone
Clomiphene and tamoxifen
Glucuronate - acetic acid - and glutathione sulfate
Prednisone
30. Toxicity caused by nitroprusside and treatment
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Cyanide toxicity treated with sodium thiosulfate
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Aspirin - Nitrates - CCB - and Beta blockers
31. What do alpha cells in the pancreas produce?
Glucagon
Log - kill hypothesis
Isoflurane
Alprostadil
32. A1a - selective blocker with no effects on HTN used for BPH
Iron deiodinates thyroxine
Thiopental
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Tamsulosin (Flomax)
33. Agent used for anemias associated with renal failure
Meperidine
Cevimeline
Cocaine
Erythropoietin
34. Produces disulfiram - like reaction with ethanol
Liver enzyme INDUCTION
Procarbazine
Rescue therapy
Mifepristone
35. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Oxytocin - ergonovine and ergotamine
Thioridazine
Edrophonium
Maintenance dose (Cp*(CL/F))
36. MOA for Valproic acid at high doses
Affect calcium - potassium - and sodium channels
Hypertension
Normal C- peptide
Methotrexate
37. Non - selective Alpha1blockers use to treat pheochromocytoma
Phenoxybenzamine
Estrogen (HRT- Hormone replacement therapy)
Prostaglandin PGF2a
Vitamin K and Fresh frozen plasma (FFP)
38. '5HT-1d agonist used for migraine headaches '
Half - life (T1/2)
Constipation - edema - and headache
Probenecid and sulfinpyrazone
Sumatriptan - naratriptan - and rizatriptan
39. This is the drug of choice for anaphylactic shock
Long acting cholinesterase inhibitors
Glucagon
Epinephrine
Ethanol
40. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease
Ultralente (humulin U)
Spasmolytic drugs
Low potency phenothiazines and ziprasidone
ORAL vancomycin
41. Term for a high margin of safety
Pyridostigmine
High therapeutic index
EOS
Diethylstilbestrol (DES)
42. Block cardiac adverse effects of thyrotoxicosis such as tachycardia - inhibits the conversion of T4 to T3
Reduce the loss from area of injection
Morphine
Ethinyl estradiol and mestranol
Beta - blockers such as propranolol
43. This agent cause increased aqueous outflow
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
L- asparaginase
Prostaglandin PGF2a
Neutropenia and agranulocytosis
44. Effective in preventing TIA's
LD50
Increasing afterload and tissue perfusion declines
Sodium channel blockers
Clopidogrel and ticlopidine
45. Antidote used for iron salt toxicity
Deferoxamine
Neutropenia and agranulocytosis
Halothane and methoxyflurane
Chlorpropamide
46. DOC for herpes and its MOA
Dobutamine and dopamine
TD50
Aldehyde dehydrogenase
Acyclovir; incorporated into viral DNA and chain termination
47. Enhances dopaminergic neurotransmission SE's include CNS excitation - acute toxic psychosis and livedo reticularis
Magnesium sulfate
Amantadine
Verapamil
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
48. Antidote for methotrexate toxicity
N- acetylcysteine
Oxytocin - ergonovine and ergotamine
Phenobarbital
Leucovorin
49. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
Naloxone (IV) - naltrexone (PO)
Heparin
Low - potency typical antipsychotics and clozapine
Flumazenil
50. Condition will result from in combination of MAOI with tyramine containing foods (ex. wine - cheese - and pickled meats)
Log - kill hypothesis
Insulin
Hypertensive crisis
Atropine - pralidoxime (2- PAM)
Sorry!:) No result found.
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