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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Period of time of therapy after which GC therapy will need to be tapered
Carbenicillin - piperacillin and ticarcillin
5-7 days
Cefixime (3rd) generation
Indomethacin
2. Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because
Cocaine 'super - speed'
Estogens increase maternal TBG
Diclofenac - ketoralac
Phentolamine
3. Type of resistance found with vancomycin
Tetracaine and bupivacaine
N- acetylcysteine (Mucomyst)
Point mutation
Naltrexone
4. SE of AGI's
Rifampin
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
PTU
IV and IM (only LMW)
5. Acetaminophen only has
Nitroglycerin sublingual tablets
Antipyretic and analgesic activity
Thrombocytopenia
Chlordiazepoxide and Diazepam
6. DOC for paroxysmal supraventricular tachycardia (PSVT)
Pilocarpine - carbachol - physostigmine
Use in IgE mediated allergic reaction
Adenosine
Hepatic
7. Drug of choice for myoclonic seizures
Valproic acid
Hepatic
Fluoxetine
Calcium channel blockers
8. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Metrifonate
Flumazenil
Pyridostigmine
Risperidone
9. Life threatening cardiac event that prolong QT leads to
Cyanide toxicity treated with sodium thiosulfate
Phenytoin
Torsades de pointes
Hyperuricemia - hypokalemia and ototoxicity
10. Common SE of sulfonylureas - repaglinide - and nateglinide
Methicillin - nafcillin - and dicloxacillin
Thioridazine
Tinnitus - GI bleeding
Hypoglycemia
11. Beta blockers partial agonist activity (intrinsic sympathomimetic activity) cause some bronchodilation and may have an advantage in treating patients with asthma
Atrial fibrillation and CHF
Steroids
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Pindolol and acebutolol
12. Vitamin given with calcium to ensure proper absorption
B- blockers
Selective inhibitor of microtubule assembly
Vitamin D
Caffeine
13. Produces disulfiram - like reaction with ethanol
Imipramine
Finasteride (Proscar and Propecia respectively)
Procarbazine
C- peptide
14. Some cell cycle specific anti - cancer drugs
Organic nitrites
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Nitroprusside
Metronidazole
15. LA causing methemoglobinemia
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Abstinence syndrome
Streptokinase
Prilocaine
16. Sedation is a common side effect of these drugs - they lower seizure threshold - uses include BAD - acute panic attacks - phobias - enuresis - and chronic pain and their overdose can be deadly
Tricyclic antidepressants (TCA)
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
Chemical esophagitis
Dimenhydrinate - meclizine - and other 1st generation
17. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
Spasmolytic drugs
Lithium
Normal C- peptide
18. Common toxicities of cisplatin
EOS
Nephro and ototoxicity
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Ascending pathways
19. Benzodiazepines that are the most effective in the treatment of panic disorder
Na+/K+ exchange
Tizanidine
Alprazolam and Clonazepam
Testosterone
20. DOC to treat chemo - induced nausea and vomiting
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Odansetron
Lepirudin
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
21. Organophosphate anthelmintic agent with long DOA
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Long acting cholinesterase inhibitors
Muscarinic blockers
Metrifonate
22. Reversal of blockade by neuromuscular blockers
Ethanol
Amphetamines
Cholinesterase inhibitors
Vitamin B12
23. SE of HMG COA reductase inhibitors
Rhabdomyolysis and Hepatotoxicity
Hepatotoxicity
Abciximab - tirofiban and eptifibatide
Clonazepam
24. NSAID contraindicated in gout
Diphendydramine
Nortriptyline - Desipramine
Aspirin
Nondepolarizing Neuromuscular Blockers
25. Causes bone marrow suppression
Lipoprotein lipase
Nesiritide (BNP)
Fexofenadine - loratadine - and cetirizine
Methotrexate
26. Penicillins active against penicillinase secreting bacteria
Severe hypertension
Ipratropium
Methicillin - nafcillin - and dicloxacillin
Low potency phenothiazines and ziprasidone
27. T3 compound less widely used
Meperidine
Calcium
Cytomel
Depression of medullary and cardiovascular centers
28. Aspirin reduces mortality in unstable angina by
Propranolol
Platelet aggregation inhibition
Ferrous sulfate
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
29. Anti - arrhythmics that decrease mortality
Adalimumab - infliximab and etanercept
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
B- blockers
Nondepolarizing Neuromuscular Blockers
30. Agent used to treat chronic gout by increasing uric acid secretion and excretion
Malathion
Hepatic
IV administration
Probenecid and sulfinpyrazone
31. Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)
Interferon alpha
Heroin - morphine - oxycodone - meperidine and fentanyl
Muscarinic blockers
Procarbazine
32. ACTH analog used for diagnosis of patients with corticosteroid abnormality
Clonazepam
Amoxicillin
Liver toxicity - increased serum cholesterol
Cosyntropin
33. Antidepressants with no effect on BP - no sedation
SSRIs
Peripheral neuritis and hepatitis
Bradykinin and histamine
Midazolam
34. Long acting beta 2 agonist used in asthma
Liver toxicity - increased serum cholesterol
Aminoglutethimide
Salmeterol
IV administration
35. Used for Cushing's syndrome (increased corticosteroid)
Cyanocobalamin (Vit B12)
Bromocriptine
Protamine sulfate
Dexamethasone suppression test
36. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea
Chemical esophagitis
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Zollinger - Ellison Syndrome
Odansetron - granisetron
37. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
Rhabdomyolysis
Tamsulosin
Suramin
PCP
38. Selective Alpha 1 blocker used for hypertension - BPH - may cause first dose orthostatic hypotension
Prazosin - terazosin - doxazosin
Cevimeline
Protease inhibitors
Apraclonidine - brimonidine
39. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
Buspirone
Dextroamphetamines and methamphetamine
Dobutamine
Selegiline
40. Antidote used for organophosphate/anticholinesterase poisoning
Tamsulosin
GFR
Atropine - pralidoxime (2- PAM)
Erythropoietin
41. Monitoring parameter to obtain before initiation of STATINS
42. System that increases in activity with chronic ethanol exposure and may contribute to tolerance
Carbamazepine
Reducing progression of heart failure (never use in acute heart failure)
EOS
Glucagon
43. Antibiotic causing red - man syndrome - and prevention
Hypoglycemia
Insulin
Vancomycin - infusion at a slow rate and antihistamines
Citalopram and its metabolite escitalopram
44. Antifungal agent used for inhibition of all gonadal and adrenal steroids
Ketoconazole
Parathion
Quetiapine
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
45. Nitrosoureas with high lipophilicity - used for brain tumors
Heroin - morphine - oxycodone - meperidine and fentanyl
Carmustine (BCNU) and lomustine (CCNU)
Amiodarone
Beta blockers
46. MAOI should not be administered with SSRI's or potent TCA's due to development of this condition
Dobutamine and dopamine
Ceftriaxone
Serotonin syndrome
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
47. The elimination of drug that occurs before it reaches the systemic circulation
Oxytocin - ergonovine and ergotamine
First pass effect
Hepatic
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
48. Class of drugs whose MOA utilizes ligand gated ion channels
Acebutolol and atenolol
Fentanyl
Didanosine
Benzodiazepines and calcium channel blockers
49. Anti - thyroid drugs
Glucagon
Ethanol
Hydroxychloroquine
Thioamides - iodides - radioactive iodine - and ipodate
50. Effective in preventing TIA's
PTU
Clopidogrel and ticlopidine
Terbutaline
Fexofenadine - loratadine - and cetirizine