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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Alpha 1selective blockers
Protamine
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Dapsone - rifampin and clofazimine combination
Carvedilol
2. Beta 1 agonists used in acute CHF
Opioid Analgesics
Topical mupirocin (Bactroban)
Dobutamine and dopamine
100% O2 and hyperbaric O2
3. MOA of cisplatin
Alkylating agent
Rifampin
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Use in IgE mediated allergic reaction
4. SE of hydroxychloroquine
Retinal destruction and dermatitis
Dobutamine and dopamine
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Aldehyde dehydrogenase
5. MOA of tetracycline
Disulfiram - like reaction
Cutaneous flush
Decreases protein synthesis by inhibiting 30S ribosome
Leuprolide
6. Shock due to septicemia or myocardial infarction is made worse by
Nondepolarizing type antagonists
Clomipramine - fluoxetine and fluvoxamine
Allopurinol
Increasing afterload and tissue perfusion declines
7. Mast cells to reduce release of hisamine and inflammatory mediators
Nifedipine
Epinephrine
Amphetamines
Calcium
8. Class of antibiotics that have 10% cross sensitivity with penicillins
Skeletal muscle tremor - tachycardia
Cephalosporins
Pre - existing cardiac or renal disease
Organic nitrites
9. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Interleukin 11 (oprelvekin)
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Little C- peptide
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
10. Drug used in cancer therapy causes Cushing - like symptoms
Timolol
Ketoralac
Prednisone
Dopamine
11. Agent that is the antidote for methanol overdose
Glucagon
Sinus tachycardia and serious arrhythmias
Beta blockers
Ethanol - fomepizole
12. Site of action of thiazide diuretics
Acetazolamide
Work at early distal convoluted tubule
Ethanol or fomepizole
Methotrexate
13. Generation of antihistamine that has the most CNS effects
First generation due to being more lipid - soluble
Ganirelix
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Work at early distal convoluted tubule
14. Vitamin given with calcium to ensure proper absorption
Neostigmine
Reducing progression of heart failure (never use in acute heart failure)
Vitamin D
Nephro and ototoxicity
15. Peakless ling acting insulin
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Terbutaline
Dantrolene
Insulin glargine
16. Agent used in the treatment of alcoholism - if alcohol is consumed concurrently - acetaldehyde builds up and results in nausea - headache - flushing - and hypotension
ACE inhibitors
Disulfiram
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Epinephrine
17. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Probenecid and sulfinpyrazone
Reducing preload
Nausea
Bupropion
18. Initial DMARD of choice for patients with RA
Methotrexate
Clopidogrel and ticlopidine
Flumazenil
Reduce aqueous secretion
19. Major nutritional side effect of bile acid - binding resins
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Prilocaine
Atropine
Trazodone
20. Dose may need to be increased during pregnancy or with Ocs due to increased TBG in plasma
Thyroxine
Volume of distribution (VD)
Ethinyl estradiol and mestranol
Anterograde amnesia
21. SE of phenytoin
Somatostatin
Gingival hyperplasia - nystagmus - diplopia and ataxia
Potential for development of Reye's syndrome
Cocaine 'super - speed'
22. Barbiturates MOA
Increase the DURATION of GABA- mediated chloride ion channels
Minocycline
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Aminocaproic acid
23. Drug that causes contraction of the uterus
Pralidoxime
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
100% O2 and hyperbaric O2
Oxytocin
24. Drug of choice for generalized anxiety disorder - Not effective in acute anxiety
N- acetylcysteine
ORAL vancomycin
Diazepam
Buspirone
25. Antiprogestin used as potent antagonist of GC receptor
Mifepristone
Doxepin
Yohimbine
Testosterone
26. SE of minoxidil
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Dry cough - hyperkalemia
Hypertrichosis
Low therapeutic index
27. Common side effect of hypnotic agents
Sedation
Alkalinize urine - dialysis
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Diazepam
28. Methyldopa is contraindicated in
Pulse therapy
Ethanol - Barbiturates - and Benzodiazepines
Vitamin K or fresh frozen plasma
Geriatrics due to its CNS (depression) effects
29. Inversely related to potency of anesthetics
TD50
Somatostatin
Thioamides - iodides - radioactive iodine - and ipodate
Minimum alveolar anesthetic concentration (MAC)
30. Long acting insulin
Cartilage damage
Excessive hypotension and kidney failure
Ultralente (humulin U)
Noncompetitive antagonist
31. Where are beta cells found in the pancreas?
Fludrocortisone and deoxycorticosterone
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Islets of Langerhans
Sodium channel blockade
32. GnRH antagonist with more immediate effects - used for infertility
Prostaglandin PGF2a
Na+/K+ exchange
Acarbose
Ganirelix
33. Term for a high margin of safety
Sodium bicarbonate
Aldehyde dehydrogenase
High therapeutic index
Partial agonist
34. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism
Bromocriptine
First order kinetics
Aspirin - Nitrates - CCB - and Beta blockers
Iodide salts
35. Thrombolytics are used for
Pulmonary embolism and DVT
Fentanyl
GFR
Digibind
36. Agent effective in physiologic and essential tremor
Bradykinin and histamine
Penicillamine
Propranolol
Hepatic
37. Reason fluoroquinolones are contraindicated in children and pregnancy
Dapsone - rifampin and clofazimine combination
Corticosteroids
Cartilage damage
Naloxone
38. Selective Alpha 1 blocker used for hypertension - BPH - may cause first dose orthostatic hypotension
Sumatriptan - naratriptan - and rizatriptan
Carmustine (BCNU) and lomustine (CCNU)
Infliximab
Prazosin - terazosin - doxazosin
39. SE of alpha blockers
Phenobarbital
Glucagon
Dry cough
Orthostatic hypotension (especially with first dose) and reflex tachycardia
40. 'Date rape drug'
Flunitrazepam (rohypnol)
Pralidoxime
Mivacurium
Diclofenac - ketoralac
41. Strong opioid agonists
Calcium
Zolpidem - zaleplon
Therapeutic index
Morphine - methadone - meperidine - and fentanyl
42. Anti - androgen used for hirsutism in females
AZT (zidovudine)
Cyproterone acetate
NSAIDS
Oxytocin - ergonovine and ergotamine
43. Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Flunitrazepam (rohypnol)
GFR
Albuterol
44. Barbiturates may precipitate this hematologic condition
Leuprolide
Chlordiazepoxide and Diazepam
Letrozole - anastrozole
Acute intermittent porphyria
45. Benzodiazepine that is used for anesthesia
Glucagon
Midazolam
Full agonist
Toremifene (Fareston)
46. Bleomycin+vinblastine+etoposide+cisplatin produce almost a 100% response when all agents are used for this neoplasm
Tissue plasmin activator
Ketamine
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Testicular cancer
47. Period of time of therapy after which GC therapy will need to be tapered
5-7 days
sodium polystyrene sulfonate (Kayexalate)
Pregnancy
Rheumatic disease
48. PTU (propylthiouracil) MOA
Glucagon
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Sermorelin
Didanosine
49. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
Calcitonin (salmon prep)
Severe hypertension
Metronidazole
Aplastic anemia and acute hepatic failure
50. Diuretic used to antagonize aldosterone receptors
Seizures
Physostigmine
Spironolactone
Esmolol