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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Carboplatin
ACE inhibitors
Capsaicin
Halothane and methoxyflurane
2. Drug causing depletion of substance P (vasodilator)
Ototoxicity
Capsaicin
Alprazolam
Fomepizole
3. Opioid antagonist that is given orally in alcohol dependency programs
Naltrexone
Competitive antagonist
Vitamin B12
Dobutamine
4. Losartan and valsartan block
Angiotensin receptor
Naloxone
Bromocriptine
Acetazolamide
5. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
Esmolol
Severe hypertension
Dobutamine
Gynecomastia and hyperkalemia
6. Antidepressant with MOA as alpha 2 antagonist - has effects on both 5- HT and NE - blocks histamine receptors - and is sedating
Miosis and constipation
Bromocriptine
Flumazenil
Mirtazapine
7. Regimen used for breast cancer
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Hypertrichosis
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
LSD
8. Epinephrine is often mixed with a local anesthetic to
Norepinephrine and serotonin
Flunitrazepam (rohypnol)
Rheumatic disease
Reduce the loss from area of injection
9. Antipsychotic having the strongest autonomic effects
Steroids
Nitroprusside
Thioridazine
Nitrous oxide
10. These agents are used as antidiarrheal
Diphenoxylate - Loperamide
Glucuronate - acetic acid - and glutathione sulfate
Nifedipine
Ability to cross the placenta
11. Agent for pernicious anemia
Cyanocobalamin (Vit B12)
Cefixime (3rd) generation
Ethanol - fomepizole
Acebutolol - atenolol - esmolol - metoprolol
12. Vascular effects of metformin
Beta1 agonists
Nondepolarizing type antagonists
Fexofenadine - loratadine - and cetirizine
Decreased micro and macro vascular disease
13. Orthostatic hypotension and QT prolongation
Low potency phenothiazines and ziprasidone
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Penicillamine
Dapsone - rifampin and clofazimine combination
14. MOA of class III antiarrhythmics
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
Potassium channel blockers
Competitive antagonist
Amoxicillin
15. Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)
N- acetylcysteine (Mucomyst)
Combination oral contraceptives (OC)
Didanosine
Atenolol - acebutolol - and metoprolol
16. Period of time of therapy after which GC therapy will need to be tapered
Atropine - homatropine - C1208 tropicamide
5-7 days
Lepirudin
Calcitonin (salmon prep)
17. Beta 2 agonist used to suppress premature labor - but cardiac stimulatory effects may be hazardous to mother and fetus
Dantrolene
Cholinesterase inhibitors
Terbutaline
Phenoxybenzamine
18. SE of loop (furosemide) diuretics
Specificity
Hyperuricemia - hypokalemia and ototoxicity
Alkylating agent
Magnesium sulfate
19. Long acting sympathomimetic - sometimes used to improve urinary continence in children and elderly with enuresis
Penicillamine
Ephedrine
Diazepam
Halothane and methoxyflurane
20. Inhibit angiotensin - converting enzyme (ACE)
Levodopa
ACE inhibitors
Nitrous oxide
Phenytoin
21. Agent used in CHF that is a selective alpha and nonselective beta blocker
Esmolol
Carvedilol
Buspirone
Methotrexate
22. Block glycoprotein IIb/IIIa involved in platelet cross - linking
Midazolam
Acute intermittent porphyria
Abciximab - tirofiban and eptifibatide
Vitamin D
23. Example of three antidepressants that are indicated for obsessive compulsive disorder
Hypertension
Clomipramine - fluoxetine and fluvoxamine
Cholinesterase inhibitors
Glucuronate - acetic acid - and glutathione sulfate
24. Fibrates (gemfibrozil) increase activity of
Lipoprotein lipase
Tamsulosin
Reduce inhibition - suppress anxiety - and produce relaxation
Estrogen
25. This is combined with L- dopa - inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L- dopa and allows for fewer SE's (GI distress - postural hypotension - and dyskinesias)
Pralidoxime
Carbidopa
LSD
Midazolam
26. ADH agonist used for pituitary diabetes insipidus
Nitrous oxide
Desmopressin (DDAVP)
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
27. Most common side effect of 1st generation antihistamines
Dry cough - hyperkalemia
Affinity
Fluoxetine (Sarafem)
Sedation
28. Drug used in exoerythrocytic cycle of malaria
Corticosteroids
Primaquine
Chlorpheniramine or cyclizine
Indomethacin
29. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Neutro - leuko and thrombocytopenia
Cholinesterase regenerators - pralidoxime
Pyridostigmine
Therapeutic index
30. Aminoglycoside that is least ototoxic
Oxytocin - ergonovine and ergotamine
Streptomycin
Sodium bicarbonate
Vancomycin - infusion at a slow rate and antihistamines
31. Agent used in acutely decompensated CHF resembling natriuretic peptide
NO - chloroform - and diethyl ether
Nesiritide (Natrecor)
Ticlopidine
Disulfiram
32. Antipsychotic having the weakest autonomic effects
Haloperidol
SEVERE myelosuppression
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
CNS depressants
33. SE for Lamotrigine
Thick ascending limb
Ganciclovir - zidovudine - saquinavir - and interferon
Deferoxamine
Stevens - Johnson syndrome
34. Class of anti - arrhythmics that has a pro - arrhythmic effect (CAST trial) - therefore are used as last line agents
Zero order kinetics
Administration of Vit. B6 (pyridoxine)
Class IC (flecainide - propafenone - moricizine)
Degradation of fibrin clots and are administered IV
35. Topical DOC in impetigo
Dextroamphetamines and methamphetamine
Paclitaxel (taxol)
Topical mupirocin (Bactroban)
Hypokalemia
36. MOA of tetracycline
Acetazolamide
Oxytocin
Oral
Decreases protein synthesis by inhibiting 30S ribosome
37. Prostaglandin used in the treatment of impotence
Xanthine oxidase
Alprostadil
Etidronate
Nitroprusside
38. Anti - seizure drugs used also for Trigeminal neuralgia
Trazodone
Carbamazepine
Hyperuricemia - hypokalemia and ototoxicity
Prostaglandin PGF2a
39. Antidote used for beta agonist toxicity (eg. Metaproterenol)
C- peptide
Vitamin B12
Blocks peptidoglycan synthesis
Esmolol
40. Angiotensin receptor blockers do Not cause
AZT (zidovudine)
Sedation
Dry cough
Paclitaxel (taxol)
41. Thrombolytics are used for
Rescue therapy
Levodopa
Pulmonary embolism and DVT
Fluoxetine
42. Drug used in ergot alkaloids overdose - ischemia and gangrene
Nitroprusside
Zolpidem - zaleplon
Heparin induced thrombocytopenia (HIT)
Ceftriaxone
43. Antidote used for lead poisoning
Cartilage damage
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Dimercaprol - EDTA
LD50
44. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Side - effect profile and prior pt response
Oxytocin - ergonovine and ergotamine
Pregnancy
Clonazepam
45. TCA used in obsessive compulsive disorder (OCD) - most significant of TCA's for risk of seizure - weight gain - and neuropsychiatric signs and symptoms
Buprenorphine
Loading dose (Cp*(Vd/F))
Clomipramine
Diclofenac - ketoralac
46. Oral antibiotic of choice for moderate inflammatory acne
Tubocurarine
Minocycline
Scopolamine - meclizine
Nitrous oxide
47. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Valproic acid
Bradykinin
Dexamethasone suppression test
Clomipramine - fluoxetine and fluvoxamine
48. Skeletal muscle agent that undergoes Hofmann elimination (breaks down spontaneously)
Atracurium
Full agonist
Angiotensin receptor
Acarbose - miglitol
49. Antidote to reverse actions of heparin
Dexrazoxane
GI bleeding
Glucocorticoids
Protamine sulfate
50. Used for SIADH
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Hypokalemia
Dolasetron
Demeclocycline