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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. MOA for benzodiazepines
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Lispro (Humalog) - aspart - glulisine
Opioid Analgesics
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
2. Irreversible - nonselective COX inhibitor
Aspirin
Carvedilol
Penicillamine
Letrozole - anastrozole
3. Most common SE of fibrates
Nonselective Muscarinic Antagonists
Prolongs QT interval
Calcium channel blockers
Nausea
4. Most useful in patients with significant anxiety - phobic features - hypochondriasis - and resistant depression
Phenytoin
Monamine oxidase inhibitors
Bone marrow and teeth discoloration for children under 8 years of age
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
5. Major SE of zileuton
Cortisone and hydrocortisone (equivalent to cortisol)
Ipodate
Liver toxicity
Aminocaproic acid
6. Antifungal agent used for inhibition of all gonadal and adrenal steroids
Phentolamine
Protamine
Ketoconazole
Tinnitus - GI bleeding
7. Anti - thyroid drugs
Vincristine
Thioamides - iodides - radioactive iodine - and ipodate
Low - potency typical antipsychotics and clozapine
Flumazenil
8. Drugs used in the management of angina
Terfenadine and astemizole (have been removed from the market)
Aspirin - Nitrates - CCB - and Beta blockers
Gastric ulcers and GI Bleeding
Sulfonamides
9. Pneumonic for beta receptors
Platelet aggregation inhibition
Ascending pathways
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Diphendydramine
10. Meningitis prophylaxis in exposed patients
Volume of distribution (VD)
Lispro (Humalog) - aspart - glulisine
Rifampin
Seizures
11. Digoxin is used in
Atrial fibrillation and CHF
Lipoprotein lipase
Spasmolytic drugs
Halothane and methoxyflurane
12. Inhalant anesthetics
TD50
Cyproterone acetate
First generation due to being more lipid - soluble
NO - chloroform - and diethyl ether
13. Shock due to septicemia or myocardial infarction is made worse by
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
Sedation
Demeclocycline
Increasing afterload and tissue perfusion declines
14. Weak opioid agonist - poor analgesic - its overdose can cause severe toxicity including respiratory depression - circulatory collapse - pulmonary edema - and seizures
Adenosine
Propoxyphene
Atrial fibrillation and CHF
Degradation of fibrin clots and are administered IV
15. For rebound HTN from rapid clonidine withdrawal
Acetazolamide
Hypertension
Prinzmetal's angina
Phentolamine
16. ACTH analog used for diagnosis of patients with corticosteroid abnormality
Streptomycin
Pulmonary embolism and DVT
Cosyntropin
Hypertension
17. Prevention of cyclophosphamide induced hemorrhagic cystitis
Administration of Vit. B6 (pyridoxine)
Paclitaxel (taxol)
Carbamazepine
Hydration and mercaptoethanesulfonate (MESNA)
18. Second generation sulfonylurea
Most are thought to act at GABA- A receptor - chloride channel
Chlorpheniramine or cyclizine
Glyburide - glipizide - glimepiride - etc.
Amiodarone
19. Vitamin given with calcium to ensure proper absorption
Lispro (Humalog) - aspart - glulisine
Nitrites
Vitamin D
Benzodiazepines and calcium channel blockers
20. These agents are CNS depressants
Competitive antagonist
N- acetylcysteine (Mucomyst)
Spironolactone
Ethanol - Barbiturates - and Benzodiazepines
21. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
Flumazenil
Diazepam
Didanosine
First order kinetics
22. System that increases in activity with chronic ethanol exposure and may contribute to tolerance
Pancuronium
EOS
Risperidone
Hydralazine
23. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Zolpidem - zaleplon
Sumatriptan
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Halothane and methoxyflurane
24. This route is associated with rapid tolerance and psychologic dependence
IV administration
Capsaicin
Older antipsychotics
Rifampin
25. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients
Letrozole - anastrozole
Indomethacin
Infants - closed angle glaucoma - prostatic hypertrophy
Beta blockers
26. Acetaminophen only has
Desmopressin (DDAVP)
Letrozole - anastrozole
Flunitrazepam (rohypnol)
Antipyretic and analgesic activity
27. MOA of sulfonamides
Inhibit dihydropteroate synthase
Valproic acid
Capsaicin
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
28. Selective alpha agonists that decreases aqueous secretion
LD50
Cholinesterase regenerators - pralidoxime
Apraclonidine - brimonidine
Phase I
29. Used for hairy cell leukemia; it stimulates NK cells
Interferon alpha
sulfamethoxazole/ trimethoprim
Insulin release from pancreas by modifying K+ channels
Insulin
30. Converts asparagine to aspartate and ammonia - denies cancer cells of essential AA (asparagine)
Salmeterol
Infants - closed angle glaucoma - prostatic hypertrophy
L- asparaginase
Oxytocin
31. Contraindications to use of atropine
Infants - closed angle glaucoma - prostatic hypertrophy
Infants
Cutaneous flush
C- peptide
32. Associated with an increased incidence of cataracts in patients treated for glaucoma
Amoxapine
N- acetylcysteine (Mucomyst)
Long acting cholinesterase inhibitors
N- acetylcysteine
33. DOC for herpes and its MOA
Acyclovir; incorporated into viral DNA and chain termination
Venlafaxine
Hydralazine
Propoxyphene
34. Chronic orthostatic hypotension can be treated with
Midodrine
Bleeding
Drug induced Parkinsonism
Acetazolamide
35. Drug ofter used in combination with TNF - alpha inhitors for RA
Dry cough - hyperkalemia
Maintenance dose (Cp*(CL/F))
Methotrexate
Testicular cancer
36. Drugs of choice for generalized tonic - clonic and partial seizures
Valproic acid and Phenytoin
Aspirin - metoprolol
Acebutolol and atenolol
Noncompetitive antagonist
37. Antidote for acetaminophen toxicity
N- acetylcysteine
Rescue therapy
First pass effect
Leuprolide
38. Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis
Inhibit dihydropteroate synthase
Ribavirin
Desmopressin (DDAVP)
Zolpidem - zaleplon
39. Slightly increased risk of breast cancer - endometrial cancer - heart disease (questionable) - has beneficial effects on bone loss
Corticosteroids
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Bioavailability (F)
Estrogen
40. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Thick ascending limb
Nandrolone - oxymetholone - and oxandrolone
Clozapine
Buprenorphine
41. MOA of cisplatin
Methadone - followed by slow dose reduction
Alkylating agent
N- acetylcysteine
Thioridazine
42. Interaction with this drug requires dose reduction of 6- MP
Allopurinol
Digibind
Liver enzyme INDUCTION
Iron deiodinates thyroxine
43. Antidote used for cyanide poisoning
Nitrites
Dextromethorphan - Codeine
hydroxyzine (Atarax)
Insulin
44. Cephalosporin causes kernicterus in neonates
Ceftriaxone or cefuroxime
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Pregnancy
nephro and ototoxicity
45. Neurologic SE of benzodiazepines
Anterograde amnesia
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Tricyclic antidepressants (TCA)
Potential for development of Reye's syndrome
46. Oral antibiotic of choice for moderate inflammatory acne
Organic nitrites
Glucagon
Retinal destruction and dermatitis
Minocycline
47. Anemia caused by trimethoprim
Megaloblastic anemia
Beta - blockers such as propranolol
Thyroxine
Cyproterone acetate
48. MOA of nystatin
Apraclonidine - brimonidine
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Epinephrine
Bind ergosterol in fungal cell membrane
49. Antipsychotics that reduce positive symptoms only
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
Older antipsychotics
Raloxifene
Urinary acidification and activated charcoal or continual nasogastric suction
50. COX 2 inhibitors may have reduced risk of
Regular (Humulin R)
Olanzapine
Gastric ulcers and GI Bleeding
TD50