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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antidote used for organophosphate/anticholinesterase poisoning
Atropine - pralidoxime (2- PAM)
Amoxapine
Ultralente (humulin U)
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
2. Reduced seizure threshold
Testicular cancer
Dexrazoxane
Low - potency typical antipsychotics and clozapine
Bleomycin
3. Inhibit angiotensin - converting enzyme (ACE)
Acute intermittent porphyria
ACE inhibitors
Echothiophate
Raloxifene
4. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors
Octreotide
Glucagon
Methoxyflurane
Sermorelin
5. Antidote to reverse actions of warfarin
ACE inhibitors
Vitamin K or fresh frozen plasma
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Dextromethorphan - Codeine
6. Usual time needed for full effect of antidepressant therapy
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
'On - off - phenomenon'
2 to 3 weeks
Glargine (Lantus) - detemir
7. Antidote used for acetaminophen (APAP) toxicity
Bupropion
Glucocorticoids
N- acetylcysteine (Mucomyst)
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
8. Metronidazole SE if given with alcohol
Sotalol
Disulfiram - like reaction
Cevimeline
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
9. Toxic effect of anticancer drug can be lessened by rescue agents
Ganciclovir - zidovudine - saquinavir - and interferon
Liver enzyme INDUCTION
Rescue therapy
Interleukin 11 (oprelvekin)
10. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Prednisone
Thrombocytopenic purpura - and CINCHONISM
Risperidone
Reduce aqueous secretion
11. Agents used in treatment of carcinoid tumor
Methotrexate
Half - life (T1/2)
Ketanserin cyproheptadine - and phenoxybenzamine
Oxidation - reduction - hydrolysis
12. Reason troglitazone was withdrawn from market
Oxytocin - ergonovine and ergotamine
Nondepolarizing Neuromuscular Blockers
Hepatic toxicity
Letrozole - anastrozole
13. Product of proinsulin cleavage used to assess insulin abuse
Fluoxetine (Sarafem)
C- peptide
Leucovorin
Increases concentration of Digoxin
14. Treatment of atropine overdose and glaucoma (because lipid soluable). Enters the CNS rapidly and has a stimulant effect - which may lead to convulsions
Physostigmine
Capsaicin
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
IV administration
15. Drugs of choice for generalized tonic - clonic and partial seizures
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Interleukin 11 (oprelvekin)
Propofol
Valproic acid and Phenytoin
16. Agent used for closure of patent ductus arteriosus
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Pentoxifylline
Reducing preload
Indomethacin
17. Population group especially sensitive to side effects of antidepressants
Elderly patients
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Propranolol
Block voltage - dependent sodium channels
18. 1st generation antihistamine that is highly sedating
Aspirin
Degradation of fibrin clots and are administered IV
Diphendydramine
Naloxone (IV) - naltrexone (PO)
19. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Nondepolarizing Neuromuscular Blockers
Meperidine
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
Buprenorphine
20. Toxicity caused by nitroprusside and treatment
Phenytoin
Cyanide toxicity treated with sodium thiosulfate
Ethanol
Point mutation
21. Mast cells to reduce release of hisamine and inflammatory mediators
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Epinephrine - dipivefrin
Adalimumab - infliximab and etanercept
Epinephrine
22. Nitroprusside vasodilates
Hepatotoxicity
Arteries and veins
Desflurane
Rifampin
23. Alpha - glucosidase inhibitor associated with elevation of LFT's
Salmeterol
Acarbose
Neutro - leuko and thrombocytopenia
Zafirlukast and montelukast
24. Non - benzodiazepine used as an anxiolytic
Hepatotoxicity
Niacin
Buspirone
Iodide salts
25. Captopril and enalapril (- OPRIL ending) are
ACE inhibitors
Flunitrazepam (rohypnol)
Cocaine
Dextroamphetamines and methamphetamine
26. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration
Epinephrine
Fentanyl
Nitrous oxide
Inhibit Na+/Cl - cotransport
27. Arterial vasodilator that works by opening K+ channels
Minoxidil
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Neostigmine
Theophylline
28. Major drug interaction with Quinidine
Insulin
Megaloblastic anemia
Organic nitrites
Increases concentration of Digoxin
29. COX 2 inhibitors should be used cautiously in pts with
Propranolol
Pre - existing cardiac or renal disease
Indomethacin
GFR
30. Class of anti - arrhythmics that has a pro - arrhythmic effect (CAST trial) - therefore are used as last line agents
Carbamazepine
Epinephrine
Class IC (flecainide - propafenone - moricizine)
PTU
31. Carbonic anhydrase inhibitor
Acetazolamide
Diazepam
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
SSRIs
32. MOA of class III antiarrhythmics
Potassium channel blockers
Gastric ulcers and GI Bleeding
Uterine contractions
Abciximab - tirofiban and eptifibatide
33. Drug elimination with a constant amount metabolized regardless of drug concentration
Sulfonamides
Nephro and ototoxicity
Buspirone
Zero order kinetics
34. Drug used for N. gonorrhea in females
Ceftriaxone
Codeine - hydrocodone - and oxycodone
Phentolamine
Cyproheptadine
35. SE of long term (>5 days) corticosteroid therapy and remedy
inhibits HMG COA reductase
Increased thromboembolic events
Adrenal suppression and weaning slowly - respectively
Excessive hypotension and kidney failure
36. Barbiturates may precipitate this hematologic condition
Kidneys
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Degradation of fibrin clots and are administered IV
Acute intermittent porphyria
37. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
Nitrous oxide
Allopurinol
Flumazenil
Physostigmine
38. Inhaled anesthetic with a low blood/gas partition coefficient
Nitrous oxide
Inhibition of protein synthesis at the 50s subunit of ribosome
Acarbose - miglitol
Oral
39. Converted to more active form DHT by 5 alpha - reductase
Testosterone
Hydroxychloroquine
Aplastic anemia and renal toxicity
Anterograde amnesia
40. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
Finasteride (Proscar and Propecia respectively)
Ipratropium
Epinephrine
Lupus - like syndrome
41. The most common type of drug interaction of sedative hypnotics with other depressant medications
Aminoglutethimide
Additive CNS depression
Timolol (nonselective) - betaxolol (selective)
Nevirapine - amprenavir
42. Antidepressant associated with seizures and cardiotoxicity
Hypoglycemia
Increasing sodium excretion and decreases arterial and venous tone
Maprotiline
Vitamin B12
43. Prostaglandins that cause abortions
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Aplastic anemia and acute hepatic failure
Beta -1 selective blockers
Ethanol - fomepizole
44. Agent used to treat MI and to reduce incidence of subsequent MI
Naloxone
Ototoxicity
Aspirin - metoprolol
Epinephrine
45. Toxicity of these agents include bradycardia - AV blockade - exacerbation of acute CHF; signs of hypoglycemia may be masked (tachycardia - tremor - and anxiety)
Beta blockers
Phenoxybenzamine
Flumazenil
Gingival hyperplasia - nystagmus - diplopia and ataxia
46. SE for Lamotrigine
Midodrine
Imipramine
Stevens - Johnson syndrome
Low - potency typical antipsychotics and clozapine
47. Rate limiting step of alcohol metabolism
Disulfiram - like reaction
Aldehyde dehydrogenase
Postsynaptic Mu receptors
Muscarinic blockers
48. SE of clonidine
Half - life (T1/2)
Amphetamines
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Rebound HTN - sedation - dry mouth
49. Drug causing depletion of substance P (vasodilator)
Midodrine
Lepirudin
Capsaicin
Hepatic toxicity
50. Beta blockers are used for which type of anginal attack
Zileuton
Classic
Diclofenac - ketoralac
Lupus - like syndrome