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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Dopamine (DA) agonist (for Parkinson's disease) - used also for hyperprolactinemia
Meperidine
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
Bromocriptine
PCP
2. MOA of colchicine (used in acute gout)
Pramipexole and ropinirole
Selective inhibitor of microtubule assembly
Amantadine
Selegiline
3. Time it takes for amount of drug to fall to half of its value; this is a constant in first order kinetics (majority of drugs)
Half - life (T1/2)
Dry cough
Fentanyl
Sulfonamides
4. SSRI less likely to cause a withdrawal syndrome
Fluoxetine
Morphine and fentanyl
Nephro and ototoxicity
Ketoralac
5. Barbiturate used for the induction of anesthesia
Thiopental
Thyroid and steroid hormones
Methotrexate
Liver toxicity - increased serum cholesterol
6. Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)
Inhibit Na+/Cl - cotransport
Flumazenil
Prostaglandin PGF2a
Amitriptyline
7. Antidote to reverse actions of heparin
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Cortisone and hydrocortisone (equivalent to cortisol)
Protamine sulfate
Zolpidem - zaleplon
8. Increased risk of developing cataracts
Quetiapine
Hypoglycemia
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Full agonist
9. Side effect of Mitomycin
Enflurane and halothane
GLUT 4
Gynecomastia hyperkalemia - and impotence
SEVERE myelosuppression
10. Topical DOC in impetigo
Topical mupirocin (Bactroban)
Nefazodone
Aminocaproic acid
Most are thought to act at GABA- A receptor - chloride channel
11. 1st generation antihistamine that is least sedating
Hyperkalemia
Reduce aqueous secretion
Carmustine (BCNU) and lomustine (CCNU)
Chlorpheniramine or cyclizine
12. Strong opioid agonists
Pre - existing cardiac or renal disease
Morphine - methadone - meperidine - and fentanyl
Lipoprotein lipase
Maprotiline
13. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
Selegiline
Indomethacin
Vancomycin
Excessive hypotension and kidney failure
14. Anti - thyroid drugs
Thioamides - iodides - radioactive iodine - and ipodate
Ethinyl estradiol and mestranol
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Niacin
15. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Scopolamine - meclizine
Clonazepam
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Ondansetron - granisetron - dolasetron and alosetron
16. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Labetalol and carvedilol
Infants - closed angle glaucoma - prostatic hypertrophy
Work at early distal convoluted tubule
Interleukin 11 (oprelvekin)
17. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Valproic acid - carbamazepine - phenytoin and gabapentin
Digoxin
Pindolol and acebutolol
Nifedipine
18. Interferes with activity of T- lymphocytes
Celecoxib
Thrombocytopenia
Hydroxychloroquine
ED50
19. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Ethanol
AZT (zidovudine)
Administration of Vit. B6 (pyridoxine)
Low potency phenothiazines and ziprasidone
20. Endogenous insulin contains
Normal C- peptide
None
Thrombocytopenic purpura - and CINCHONISM
Sumatriptan
21. Antiprogestin used as potent antagonist of GC receptor
Pulmonary embolism and DVT
Bromocriptine
Etidronate
Mifepristone
22. Benzodiazepine used for anxiety
Alprazolam
Regular (Humulin R)
Therapeutic index
Increases concentration of Digoxin
23. Inhaled anesthetic that may sensitize the myocardium to arrhythmogenic effects of catecholamines and has produced hepatitis
Halothane
Phase I
sodium polystyrene sulfonate (Kayexalate)
Postsynaptic Mu receptors
24. Antidepressant also used for sleep that causes priapism
Tolerance
Dry cough - hyperkalemia
Kidney and liver toxicity - diarrhea
Trazodone
25. Converted to more active form DHT by 5 alpha - reductase
Testosterone
Nefazodone
Folic acid
Inhibits osteoclast bone resorption
26. '5HT-1d agonist used for migraine headaches '
Naloxone (IV) - naltrexone (PO)
GI bleeding
Sumatriptan - naratriptan - and rizatriptan
Labetalol and carvedilol
27. Readily detected markers that may assist in diagnosis of the cause of a drug overdose include
Low - potency typical antipsychotics and clozapine
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Ototoxicity
Mannitol
28. SE of hydralazine
Full agonist
Kidney and liver toxicity - diarrhea
Tissue plasmin activator
Lupus - like syndrome
29. Agent used in CHF that is a selective alpha and nonselective beta blocker
Carvedilol
Cortisone and hydrocortisone (equivalent to cortisol)
Hypercalcemia
Chemical esophagitis
30. MOA of nitrates
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Ipodate
Aspirin irreversibly inhibits cyclooxygenase
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
31. Drugs of choice for status epilepticus
Aldehyde dehydrogenase
Tetracaine and bupivacaine
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
32. Drug increases the renal clearance hence decreases levels of lithium
Tolerance
Buspirone
Theophylline
Tubocurarine
33. Site of action of thiazide diuretics
Gingival hyperplasia
Work at early distal convoluted tubule
Theophylline
Lorazepam - oxazepam - and temazepam
34. Anti - rheumatic agent also used for Chron's disease
Infliximab
PCP
ED50
'On - off - phenomenon'
35. Thrombolytics are used for
Pulmonary embolism and DVT
Quetiapine
Methotrexate
Sotalol
36. Anti - psychotics available in depot preparation
Positive Comb's test - depression
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Fluphenazine and haloperidol
5- flouracil (5- FU)
37. The most common type of drug interaction of sedative hypnotics with other depressant medications
Little C- peptide
Additive CNS depression
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Carbidopa
38. Agent used to treat MI and to reduce incidence of subsequent MI
Bromocriptine
Ganciclovir - zidovudine - saquinavir - and interferon
Peripheral neuritis and hepatitis
Aspirin - metoprolol
39. Agent to treat hypochromic microcytic anemias
'On - off - phenomenon'
Ferrous sulfate
Disulfiram - like reaction
Etidronate
40. Anti - androgen used for prostate cancer
Topical mupirocin (Bactroban)
Postsynaptic Mu receptors
Flutamide (Eulexin)
Enflurane and halothane
41. These beta blockers are less lipid soluble
Cefixime (3rd) generation
N- acetylcysteine
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Acebutolol and atenolol
42. Concern using lithium
Low therapeutic index
Tamsulosin (Flomax)
Spironolactone
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
43. Sedative - Hypnotics action
Reduce inhibition - suppress anxiety - and produce relaxation
Mivacurium
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Miosis and constipation
44. Chelating agent used in Wilson's disease
5-7 days
Penicillamine
Aspirin - Nitrates - CCB - and Beta blockers
IV and IM (only LMW)
45. MOA of lovastatin (STATIN)
inhibits HMG COA reductase
First order kinetics
Venlafaxine
Dopamine blockade
46. Presynaptic Alpha 2 agonist used in HTN - and acts centrally
Clonidine - and methyldopa
Benzodiazepines and calcium channel blockers
Topical mupirocin (Bactroban)
Diphendydramine
47. 'Date rape drug'
Flunitrazepam (rohypnol)
Classic
Retinal destruction and dermatitis
Barbiturates - phenytoin - carbamazepine - and rifampin
48. CCB contraindicated in CHF
Kidneys
Verapamil
Midazolam
First generation due to being more lipid - soluble
49. SE of Thiazolindinediones
Topical mupirocin (Bactroban)
Lispro (Humalog) - aspart - glulisine
Prilocaine
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
50. Antidote used for warfarin toxicity
ORAL vancomycin
Vitamin K and Fresh frozen plasma (FFP)
Severe hypertension
Chlordiazepoxide and Diazepam