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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. DOC for giardia - bacterial vaginosis - pseudomembranous colitis - and trichomonas
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Thyroxine
Metronidazole
Flumazenil
2. Muscarinic antagonist used in asthma
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Beta blockers
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Ipratropium
3. Tolerance is marked and abstinence syndrome occurs
Amphetamines
Dolasetron
Prolongs QT interval
Epinephrine - dipivefrin
4. Anabolic steroid that has potential for abuse
Echothiophate
Nandrolone - oxymetholone - and oxandrolone
Phentolamine
sulfamethoxazole/ trimethoprim
5. Alpha 1 agonist toxicity
Beta1 agonists
Erythromycin
Hypertension
Morphine
6. SE of lithium
Normal C- peptide
Valproic acid
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Oxytocin
7. Some of SSRIs' therapeutic effects beside depression
Somatostatin
Halothane and methoxyflurane
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Overdose of opioids
8. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
Epinephrine
Acarbose - miglitol
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Monamine oxidase inhibitors
9. Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates
Allopurinol
L- dopa
Mifepristone (RU-486)
Toremifene (Fareston)
10. MOA of loop diuretics
Odansetron - granisetron
Zolpidem - zaleplon
inhibits Na+/K+/2Cl - cotransport
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
11. Term for a narrow margin of safety
Low therapeutic index
Dopamine
Cocaine
Edrophonium
12. CCB with predominate effect on arteriole dilation
Combination oral contraceptives (OC)
Liver toxicity - increased serum cholesterol
Nifedipine
Mifepristone (RU-486)
13. 3 zones of adrenal cortex and their products
Antithrombin 3
Hallucinations resembling psychosis
Buspirone
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
14. Used especially in postmenopausal women - dosage should be 1500 mg
Little C- peptide
Calcium
Bromocriptine
Iron deiodinates thyroxine
15. MOA of quinolones
Vancomycin - infusion at a slow rate and antihistamines
Magnesium sulfate
Inhibit DNA gyrase
Volume of distribution (VD)
16. Common toxicities of cisplatin
Carbidopa
Nephro and ototoxicity
Barbiturates - phenytoin - carbamazepine - and rifampin
Erythropoietin
17. Meningitis prophylaxis in exposed patients
Dipyridamole
Rifampin
Hypoglycemia
Codeine - hydrocodone - and oxycodone
18. B- blockers that are more cardioselective
Elderly patients
G- CSF (filgrastim) and GM- CSF (sargramostim)
Beta -1 selective blockers
Bradykinin
19. HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
Nifurtimox
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Aspirin - Nitrates - CCB - and Beta blockers
Protease inhibitors
20. This may enhance activity of local anesthetics
Diphenoxylate - Loperamide
Suramin
Hyperkalemia
Radioactive iodine
21. Drug causing depletion of substance P (vasodilator)
Capsaicin
Megaloblastic anemia
Acebutolol - atenolol - esmolol - metoprolol
Levodopa
22. Beta - blockers should be used cautiously in
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Hypertensive crisis
Deferoxamine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
23. Alternative anticoagulant used if HIT develops
Aspirin - Nitrates - CCB - and Beta blockers
Full agonist
Beta - blockers such as propranolol
Lepirudin
24. Antidote used for benzodiazepine toxicity
Flumazenil
Ethanol or fomepizole
Didanosine
Dry cough
25. Ergot alkaloid used as an illicit drug
Islets of Langerhans
Carvedilol
LSD
Ezetimibe (Zetia)
26. Nitrate used to prevent further attacks
Clomipramine - fluoxetine and fluvoxamine
St. Anthony's Fire
Oral and transdermal forms of nitroglycerin
Thrombocytopenic purpura - and CINCHONISM
27. Life threatening cardiac event that prolong QT leads to
Aminocaproic acid
Metronidazole
Torsades de pointes
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
28. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property
Vitamin D
Liver enzyme INDUCTION
Inhibit dihydropteroate synthase
Rescue therapy
29. MOA of tetracycline
LFT's
Dantrolene
Decreases protein synthesis by inhibiting 30S ribosome
SSRI's - bupropion - and venlafaxine
30. Antidepressant with MOA as alpha 2 antagonist - has effects on both 5- HT and NE - blocks histamine receptors - and is sedating
NSAIDS
Fluoxetine
Mirtazapine
Estrogen (HRT- Hormone replacement therapy)
31. Antidote used for digitalis toxicity
6- mercaptopurine (6- MP)
Amphetamines
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Carmustine (BCNU) and lomustine (CCNU)
32. DOC for herpes and its MOA
Carbamazepine
Spasmolytic drugs
Acyclovir; incorporated into viral DNA and chain termination
Potassium channel blockers
33. Prototype antagonist of H1 and H2 receptors
Diphenhydramine and cimetridine - respectively
Lorazepam - oxazepam - and temazepam
Na+/K+ exchange
Mannitol
34. Inhibitor of lipoxygenase
Thiopental
Vasodilation
Patches - gum - nasal spray - psychotherapy - and bupropion
Zileuton
35. Long acting insulin
Ultralente (humulin U)
Tamoxifen
Cyanocobalamin (Vit B12)
Sumatriptan
36. These agents are used as antidiarrheal
Ondansetron - granisetron - dolasetron and alosetron
Diphenoxylate - Loperamide
Tubocurarine
L- thyroxine (T4)
37. Thrombolytic that can cause allergic reaction
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Streptokinase
Phenoxybenzamine
CNS depressants
38. Opioids used in anesthesia
Positive Comb's test - depression
Amantadine
Hepatic enzymes
Morphine and fentanyl
39. Skeletal muscle agent that can block muscarinic receptors
Fluorocarbons and Industrial solvents
Hypertension
Rifampin
Pancuronium
40. Amphetamine agents
Acebutolol and atenolol
Dextroamphetamines and methamphetamine
Acetazolamide
Neutropenia and agranulocytosis
41. MOA of NSAIDS
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
Hyperuricemia - hypokalemia and ototoxicity
Acetazolamide
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
42. Side effect of Mitomycin
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
pregnancy and with K+
Tetracaine and bupivacaine
SEVERE myelosuppression
43. TCA used in chronic pain - enuresis - and ADD
Methadone
Cisplatin
Potency
Imipramine
44. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
Aspirin irreversibly inhibits cyclooxygenase
Diphenoxylate - Loperamide
sodium polystyrene sulfonate (Kayexalate)
Succinylcholine
45. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Buspirone
Labetalol and carvedilol
Cholinesterase regenerators - pralidoxime
Most are thought to act at GABA- A receptor - chloride channel
46. Non - depolarizing skeletal muscle antagonist that has short duration
Nitrous oxide
Ketanserin cyproheptadine - and phenoxybenzamine
Inhibit Na+/Cl - cotransport
Mivacurium
47. Anti - thyroid drugs
Rebound HTN - sedation - dry mouth
Bile acid - binding resins
Abstinence syndrome
Thioamides - iodides - radioactive iodine - and ipodate
48. Barbiturates may precipitate this hematologic condition
Acute intermittent porphyria
Ganirelix
Tissue plasmin activator
Mifepristone
49. Carbamazepine may cause
Decreases protein synthesis by inhibiting 30S ribosome
Terfenadine and astemizole (have been removed from the market)
Agranulocytosis
Amphetamines
50. The most common neurologic abnormality in chronic alcoholics
Sedation
Cortisone and hydrocortisone (equivalent to cortisol)
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Clonazepam