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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Alpha 1 agonist toxicity
Finasteride (Proscar and Propecia respectively)
Hydralazine
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
Hypertension
2. Agent used for anemias associated with renal failure
Aminocaproic acid
Erythropoietin
Abstinence syndrome
Elderly patients
3. Anti - rheumatic agent also used for Chron's disease
Inhibit DNA gyrase
Dipyridamole
Pre - existing cardiac or renal disease
Infliximab
4. Long acting glucocorticoids
Nitroglycerin sublingual tablets
Betamethasone and dexamethasone
Alprostadil
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
5. Agent that is the antidote for methanol overdose
Ethanol - fomepizole
Acebutolol - atenolol - esmolol - metoprolol
Efficacy
Insulin release from pancreas by modifying K+ channels
6. IV barbiturate used as a pre - op anesthetic
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Prostaglandin PGF2a
Rescue therapy
Thiopental
7. Long acting sympathomimetic - sometimes used to improve urinary continence in children and elderly with enuresis
2 to 3 weeks
Labetalol and carvedilol
Geriatrics due to its CNS (depression) effects
Ephedrine
8. Approved for use in severe pulmonary HTN
PGI2 (epoprostenol)
Clomipramine - fluoxetine and fluvoxamine
Ethanol - Barbiturates - and Benzodiazepines
Peripheral neuritis and hepatitis
9. Anti - arrhythmic with 15 second duration of action
Ticlopidine
Ketanserin cyproheptadine - and phenoxybenzamine
Primaquine
Adenosine
10. Longer acting local anesthetics which are less dependent on vasoconstrictors
Fexofenadine - loratadine - and cetirizine
Sumatriptan - naratriptan - and rizatriptan
Tetracaine and bupivacaine
Leucovorin
11. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Aspirin - Nitrates - CCB - and Beta blockers
Mannitol
Sulfonamides
Beta1 agonists
12. Tubocurarine is the prototype - pancuronium - atracurium - vecuronium are newer short acting agent - produce competitive block at end plate nicotinic receptor - causing flaccid paralysis
Aztreonam
Tubocurarine
Nondepolarizing Neuromuscular Blockers
Aspirin
13. Agent which stimulates cardiac contractile force more than rate with little effect on total peripheral resistance
Na+/K+ exchange
Dobutamine
Dantrolene
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
14. Agent used for acute muscle spasm
Gynecomastia hyperkalemia - and impotence
Cyclobenzaprine
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Serum ammonia and LFT's
15. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Calcium channel blockers
prolongs QT and PR interval
Rescue therapy
Valproic acid
16. DOC for Legionnaires' disease
Erythromycin
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Chlorpheniramine or cyclizine
Epinephrine - dipivefrin
17. DOC for bipolar affective disorder
Diazepam
Ganirelix
Cerebral hemorrhage
Lithium
18. GABA agonist in the spinal cord
Baclofen
Amantadine
Affinity
Dapsone - rifampin and clofazimine combination
19. System that increases in activity with chronic ethanol exposure and may contribute to tolerance
Pulse therapy
EOS
Carbenicillin - piperacillin and ticarcillin
Minimum alveolar anesthetic concentration (MAC)
20. Prostaglandins that cause abortions
Isoflurane
SSRI's - bupropion - and venlafaxine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Fentanyl
21. Thiazolidinediones
Prilocaine
Lithium toxicity
Reducing preload
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
22. Cephalosporins Not able to cross the BBB
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Inhibit DNA gyrase
Dapsone - rifampin and clofazimine combination
Cefixime (3rd) generation
23. Inhalant anesthetics
Loading dose (Cp*(Vd/F))
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Flumazenil
NO - chloroform - and diethyl ether
24. Oral contraceptive available in a transdermal patch
Ortho - Evra
Maprotiline
Normal C- peptide
Positive Comb's test - depression
25. Receptors for serotonin (5HT-1) are located
Hepatotoxicity
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Naloxone
Aminoglutethimide
26. Inhaled anesthetic causes peripheral vasodilation
Isoflurane
Lactic acidosis
Phentolamine
Norepinephrine and serotonin
27. SE of heparin
Heparin induced thrombocytopenia (HIT)
Nitrites
Citalopram and its metabolite escitalopram
Gabapentin
28. Anti - psychotics available in depot preparation
Desflurane
Cocaine 'super - speed'
Fluphenazine and haloperidol
Bleomycin
29. SE of spironolactone
Yohimbine
Gynecomastia hyperkalemia - and impotence
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Phentolamine
30. Except for these agents all SSRI have significant inhibition of CytP450 enzymes
Naloxone
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Citalopram and its metabolite escitalopram
Serum ammonia and LFT's
31. Antidote for hyperkalemia
sodium polystyrene sulfonate (Kayexalate)
Bind ergosterol in fungal cell membrane
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Mannitol
32. Chronic high dose abuse of nicotine leads to
Reduce the loss from area of injection
Primaquine
Neuromuscular blocking drugs
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
33. Antidote used for digitalis toxicity
Aplastic anemia and acute hepatic failure
Vitamin B12
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Phenoxybenzamine
34. Barbiturates MOA
TD50
Tolerance
Increase the DURATION of GABA- mediated chloride ion channels
GABA- related targets
35. Only direct acting agent that is very lipid soluble and used in glaucoma
Side - effect profile and prior pt response
5-7 days
Pilocarpine
Norepinephrine and serotonin
36. These beta blockers are less lipid soluble
Niacin
Acebutolol and atenolol
Naloxone
Tricyclic antidepressants (TCA)
37. NSAID used in gout
Norepinephrine and serotonin
Lorazepam - oxazepam - and temazepam
Rescue therapy
Indomethacin
38. Agents that reduce heart rate - contractility - and O2 demand
Phentolamine
Flumazenil
Beta - blockers
Clindamycin
39. Antidepressant inhibiting norepinephrine - serotonin - and dopamine reuptake
Clomipramine - fluoxetine and fluvoxamine
Radioactive iodine
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Venlafaxine
40. DOC for status epilepticus
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Atropine - pralidoxime (2- PAM)
Diazepam
Aspirin - Nitrates - CCB - and Beta blockers
41. Non - steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
Trazodone
Amoxapine
Amiodarone
Diethylstilbestrol (DES)
42. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Leuprolide
Glucocorticoids
Ketoralac
Mannitol
43. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
Desmopressin (DDAVP)
Dantrolene
Succinylcholine
Ethanol or fomepizole
44. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia
Morphine - methadone - meperidine - and fentanyl
Phenylephrine
Nitrous oxide
Sumatriptan - naratriptan - and rizatriptan
45. MOA of colchicine (used in acute gout)
Selective inhibitor of microtubule assembly
NO - chloroform - and diethyl ether
Atropine - homatropine - C1208 tropicamide
Minimum alveolar anesthetic concentration (MAC)
46. Antidote used for acetaminophen (APAP) toxicity
N- acetylcysteine (Mucomyst)
Aminocaproic acid
Flumazenil
N- acetylcysteine
47. Agents used in treatment of carcinoid tumor
Aminocaproic acid
Classic
Dolasetron
Ketanserin cyproheptadine - and phenoxybenzamine
48. Anabolic steroid that has potential for abuse
Gingival hyperplasia
Nortriptyline - Desipramine
Nandrolone - oxymetholone - and oxandrolone
Lithium toxicity
49. Drugs of choice for status epilepticus
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Haloperidol or pimozide
GABA- related targets
50. Antidote used for lead poisoning
Morphine and fentanyl
Dimercaprol - EDTA
Mirtazapine
Risperidone