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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Bile acid - binding resins
Esmolol
Kidney and liver toxicity - diarrhea
Thioridazine
2. Anti - seizure drugs used also for pain of neuropathic orgin
Efficacy
Gabapentin
Increases concentration of Digoxin
Clonidine - and methyldopa
3. Type of resistance found with vancomycin
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Gingival hyperplasia - nystagmus - diplopia and ataxia
Steroids
Point mutation
4. Inhaled anesthetic causes peripheral vasodilation
Isoflurane
Leucovorin
Naloxone
Valproic acid - carbamazepine - phenytoin and gabapentin
5. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Long acting cholinesterase inhibitors
Corticosteroids
Beta1 agonists
Pregnancy
6. Opioid associated with respiratory depression - but is used in high risk patients who may not survive full general anesthetia
Ethanol - fomepizole
Fentanyl
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Niacin
7. Prostaglandins that cause abortions
Naloxone (IV) - naltrexone (PO)
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
C- peptide
Xanthine oxidase
8. Alpha 1selective blockers
Vincristine
Diethylstilbestrol (DES)
Opioid Analgesics
Prazosin - terazosin and doxazosin (- AZOSIN ending)
9. Pyrimidine analog that causes 'Thymine - less death' given with leucovorin rescue
Barbiturates - phenytoin - carbamazepine - and rifampin
5- flouracil (5- FU)
Clonazepam
IV administration
10. SE of thiazide (HCTZ) diuretics
Serotonin syndrome
Hyperuricemia - hypokalemia and hyperglycemia
Cartilage damage
'On - off - phenomenon'
11. Estrogen mostly used in oral contraceptives (OC)
Methotrexate
Ethinyl estradiol and mestranol
IV administration
Imipramine
12. Drugs of choice for status epilepticus
Isoflurane
Toremifene (Fareston)
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Albuterol
13. MOA of local anesthetics (LA's)
Capsaicin
Block voltage - dependent sodium channels
Niacin
Meperidine
14. Cystitis - postoperative bladder spasms - or incontinence
Atenolol - acebutolol - and metoprolol
Pramipexole and ropinirole
Cosyntropin
Oxybutynin - dicyclomine
15. What do alpha cells in the pancreas produce?
Buprenorphine
Edrophonium
Glucagon
Presynaptic mu - delta - and kappa receptors
16. Antidepressants with no effect on BP - no sedation
Thiopental
Bradykinin
SSRIs
Cytomel
17. SE of Amiodarone
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Midazolam
Nitrous oxide
Olanzapine - aripiprazole - and sertindole
18. Antihistamine that can be used for anxiety and insomnia and is not addictive
hydroxyzine (Atarax)
Desmopressin (DDAVP)
Ability to cross the placenta
Penicillamine
19. Inhaled anesthetics are myocardial depressants
Salmeterol
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Enflurane and halothane
Dopamine
20. Toxicity of amphotericin
Morphine and fentanyl
Nephrotoxicity
Estrogen (HRT- Hormone replacement therapy)
Adenosine
21. Thrombolytics are used for
Pulmonary embolism and DVT
Epinephrine
Hypoglycemia
Half - life (T1/2)
22. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation
Erythromycin
Chlorpheniramine or cyclizine
Fluorocarbons and Industrial solvents
Spironolactone
23. Laboratory value required to be monitored for patients on valproic acid
24. Route of administration of warfarin
Sedation
DOM - STP - MDA - and MDMA 'ecstasy'
Rebound HTN - sedation - dry mouth
Oral
25. Aspirin is contraindicated in children with viral infection
26. Agent used in acutely decompensated CHF resembling natriuretic peptide
Nesiritide (Natrecor)
sulfamethoxazole/ trimethoprim
Ganirelix
Naloxone
27. Prototypical drug is atropine
Nonselective Muscarinic Antagonists
Aminocaproic acid
Low potency phenothiazines and ziprasidone
Positive Comb's test - depression
28. Carbonic anhydrase inhibitor
Reducing progression of heart failure (never use in acute heart failure)
Dry cough - hyperkalemia
Acetazolamide
Epinephrine
29. SE of colchicine
Geriatrics due to its CNS (depression) effects
Megaloblastic anemia
Kidney and liver toxicity - diarrhea
Naloxone
30. Agent that is a partial agonist for the 5- HT1A receptor
Buspirone
Glucagon
Estrogen (HRT- Hormone replacement therapy)
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
31. Scabicide organophosphate
Malathion
Iron deiodinates thyroxine
Epinephrine
Fluphenazine and haloperidol
32. Anti - emetics used in association with anti - cancer drugs that are 5- HT3 (serotonin receptor subtype ) antagonists
Sodium channel blockade
Deferoxamine
Odansetron - granisetron
Neutropenia and agranulocytosis
33. Antidote used for beta agonist toxicity (eg. Metaproterenol)
Esmolol
Procarbazine
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
First pass effect
34. Reduced seizure threshold
Valproic acid
Spasmolytic drugs
Low - potency typical antipsychotics and clozapine
REM is decreased
35. Sedative - Hypnotics action
Midodrine
Reduce the loss from area of injection
Methotrexate
Reduce inhibition - suppress anxiety - and produce relaxation
36. Agents used in Tourette's dx
Haloperidol or pimozide
Ticlopidine
5-7 days
Bone marrow and teeth discoloration for children under 8 years of age
37. Treat manifestations of Parkinson's disease and EPS
Hyperkalemia
Benztropine - trihexyphenidyl
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Bradykinin and histamine
38. Intermediate acting glucocorticoids
Selegiline
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Propoxyphene
39. Cephalosporins able to cross the BBB
Increase the DURATION of GABA- mediated chloride ion channels
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
Halothane and methoxyflurane
Hydralazine
40. The selective agents loose their selectivity at
high doses
NSAIDS
CNS stimulation; GI upset
Buspirone
41. Agent that is teratogen and causes a fetal syndrome
Work at early distal convoluted tubule
Malathion
Ketanserin cyproheptadine - and phenoxybenzamine
Ethanol
42. DOC for RSV
Magnesium sulfate
Oxytocin - ergonovine and ergotamine
Naloxone
Ribavirin
43. Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA
Mivacurium
Hepatic enzymes
Tissue plasmin activator
Hallucinations resembling psychosis
44. Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs
Chlordiazepoxide and Diazepam
Digibind
Serum ammonia and LFT's
Hyperuricemia - hypokalemia and ototoxicity
45. Endogenous insulin contains
Glucagon
Erythromycin
Buspirone
Normal C- peptide
46. Major route of elimination for Lithium
Kidneys
Aminocaproic acid
Propranolol
Etidronate
47. Anti - thyroid drugs
Thioamides - iodides - radioactive iodine - and ipodate
Bromocriptine
Carbamazepine
Epinephrine
48. Newer atypical antipsychotic used for bipolar disorder - known to cause weight gain - and adversely affect diabetes
Ortho - Evra
Paclitaxel (taxol)
Methotrexate
Olanzapine
49. Barbiturate used for the induction of anesthesia
Benztropine
Tertiary amines
Thiopental
Adenosine
50. Population group especially sensitive to side effects of antidepressants
sodium polystyrene sulfonate (Kayexalate)
Entacapone and Tolcapone
Elderly patients
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures