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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug used in exoerythrocytic cycle of malaria
Adalimumab - infliximab and etanercept
Cefixime (3rd) generation
Primaquine
Tetracaine and bupivacaine
2. SE for ganciclovir
Ascending pathways
Succinylcholine
Terbutaline
Neutro - leuko and thrombocytopenia
3. Reduced seizure threshold
Hydration and mercaptoethanesulfonate (MESNA)
Pindolol and acebutolol
Low - potency typical antipsychotics and clozapine
Oral
4. Rapid acting - crystalline zinc insulin used to reverse acute hyperglycemia
Calcium channel blockers
Regular (Humulin R)
Methicillin - nafcillin - and dicloxacillin
Abstinence syndrome
5. Mast cells to reduce release of hisamine and inflammatory mediators
inhibits HMG COA reductase
Rifampin
Epinephrine
Rhabdomyolysis
6. Agent effective in physiologic and essential tremor
Bioavailability (F)
Propranolol
Beta -1 selective blockers
Autocoids
7. This beta blocker is highly lipid soluble and may account for side effects such as nightmares
Midazolam
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Propranolol
Beta -1 selective blockers
8. Most common side effect of 1st generation antihistamines
Adrenal suppression and weaning slowly - respectively
Haloperidol or pimozide
Sedation
Hypokalemia
9. Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis
Clonidine - and methyldopa
Risperidone
Fluoxetine
Albuterol
10. Median toxic dose required for a toxic effect in 50% of the population
ACE inhibitors
TD50
Vancomycin - infusion at a slow rate and antihistamines
Oral
11. Microtubule inhibitor that causes peripheral neuropathy - foot drop (eg. ataxia) - and 'pins and needles' sensation
Fentanyl
Islets of Langerhans
Sulfasalazine
Vincristine
12. Used especially in postmenopausal women - dosage should be 1500 mg
Calcium
Aminocaproic acid
Potency
Insulin
13. Metronidazole SE if given with alcohol
Entacapone and Tolcapone
Low - potency typical antipsychotics and clozapine
Disulfiram - like reaction
Mannitol
14. This route is associated with rapid tolerance and psychologic dependence
Interleukin 11 (oprelvekin)
Propranolol
Calcium
IV administration
15. 5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease
Haloperidol
Dolasetron
SSRIs
Naloxone (IV) - naltrexone (PO)
16. DOC for herpes and its MOA
Patches - gum - nasal spray - psychotherapy - and bupropion
Specificity
Dopamine blockade
Acyclovir; incorporated into viral DNA and chain termination
17. Agent that inhibits alcohol dyhydrogenase and its clinical use
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
LFT's
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Thiopental
18. Available bisphosphonates
Low therapeutic index
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Prednisone
LD50
19. Beta 2 agonist toxicity
Thioridazine
Spironolactone
Skeletal muscle tremor - tachycardia
Chlorpheniramine or cyclizine
20. SE of loop (furosemide) diuretics
Nondepolarizing Neuromuscular Blockers
Betamethasone and dexamethasone
Hyperuricemia - hypokalemia and ototoxicity
Clindamycin
21. Anti - thyroid drugs
Vincristine
Iron deiodinates thyroxine
Thioamides - iodides - radioactive iodine - and ipodate
2 to 3 weeks
22. DOC for paroxysmal supraventricular tachycardia; has high efficacy and short duration of action
Digoxin
Adenosine
Leucovorin
Excessive CNS stimulation (seizures)
23. Irreversible condition resulting from the use of antipsychotics - reserpine at high doses - and MPTP (by- product of illicit meperidine analog)
Drug induced Parkinsonism
Anterograde amnesia
Midazolam
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
24. DOC for management of acute ventricular arrhythmias
Dopamine
AZT (zidovudine)
Esmolol
Amiodarone
25. DMARDs are slow acting drugs for
Vancomycin - infusion at a slow rate and antihistamines
Fentanyl
Labetalol and carvedilol
Rheumatic disease
26. Readily detected markers that may assist in diagnosis of the cause of a drug overdose include
Tolerance
Aspirin
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
ACE inhibitors
27. Anti - progesterone used as abortifacient
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Physostigmine
Kidneys
Mifepristone (RU-486)
28. Antidote used for anticholinergic poisoning
Leuprolide
Enflurane and halothane
Physostigmine
Aztreonam
29. Local anesthetic with vasoconstrictive property - favored for head - neck - and pharyngeal surgery
Cocaine
Aspirin - metoprolol
ORAL vancomycin
Hypertrichosis
30. Primary endogenous substrate for Nitric Oxidase Synthase
Arginine
Ketoconazole
Aplastic anemia and renal toxicity
Point mutation
31. Diuretics work in CHF by
Elderly patients
Reducing preload
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Pralidoxime - atropine
32. Antidote useful for some drug induced Torsade de pointes
Minocycline
Epinephrine
Magnesium sulfate
Atropine
33. SE for Felbamate
Labetalol and carvedilol
Celecoxib and rofecoxib
PGI2 (epoprostenol)
Aplastic anemia and acute hepatic failure
34. MOA of class III antiarrhythmics
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Increased thromboembolic events
Potassium channel blockers
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
35. Treatment of myasthenia gravis
Inhibit Na+/Cl - cotransport
Ganciclovir - zidovudine - saquinavir - and interferon
Fexofenadine - loratadine - and cetirizine
Pyridostigmine
36. Site of action of thiazide diuretics
Dobutamine
Cosyntropin
Clonazepam
Work at early distal convoluted tubule
37. Chelating agent used in Wilson's disease
nephro and ototoxicity
Hyperuricemia - hypokalemia and ototoxicity
Esmolol
Penicillamine
38. MOA of thrombolytics
Degradation of fibrin clots and are administered IV
Probenecid and sulfinpyrazone
Deferoxamine
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
39. Agent to treat hypochromic microcytic anemias
Stimulates cGMP which leads to vascular smooth muscle relaxation
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Ferrous sulfate
Low potency phenothiazines and ziprasidone
40. Condition will result from in combination of MAOI with tyramine containing foods (ex. wine - cheese - and pickled meats)
Propranolol
Celecoxib
Diazepam
Hypertensive crisis
41. Peptide drug used to treat CHF
Nesiritide (BNP)
Mifepristone (RU-486)
Prolonged half - life - up to six weeks
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
42. Limiting side effect of Quinidine
Administration of Vit. B6 (pyridoxine)
Degradation of fibrin clots and are administered IV
Prolongs QT interval
PTU
43. Treatment for TB patients (think RIPE)
Dobutamine
Lipoprotein lipase
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Maprotiline
44. Shock due to septicemia or myocardial infarction is made worse by
Increasing afterload and tissue perfusion declines
Gingival hyperplasia - nystagmus - diplopia and ataxia
Dimercaprol
Erythromycin
45. CCB are DOC for
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46. Biguanide
inhibits Na+/K+/2Cl - cotransport
Toremifene (Fareston)
Metformin
Malathion
47. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Nitrous oxide
Naloxone
Risperidone
Fluoxetine (Sarafem)
48. MOA of drug or foods (grapefruit juice) that increase statin effect
Liver enzyme INDUCTION
Valproic acid
Inhibit Cytochrome P450 3A4
Phenoxybenzamine
49. Cause dizziness - tachycardia - hypotension - and flushing
Low therapeutic index
Aspirin - metoprolol
Organic nitrites
Naloxone
50. Cutaneous flush and be reduced by pretreatment with
Ganciclovir - zidovudine - saquinavir - and interferon
Arteries and veins
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Aspirin