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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Side effects occuring in antipsychotics that block dopamine
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Fluoxetine
Partial agonist
Clozapine
2. Barbiturate used for the induction of anesthesia
Administration of Vit. B6 (pyridoxine)
Stimulates cGMP which leads to vascular smooth muscle relaxation
Geriatrics due to its CNS (depression) effects
Thiopental
3. Antidepressant associated with seizures and cardiotoxicity
Therapeutic index
Calcium
Serotonin syndrome
Maprotiline
4. Agent having no effect on D2 receptors - blocks D4 - reserved for resistant schizophrenia - and can cause fatal agranulocytosis
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Clozapine
Liver toxicity
Side - effect profile and prior pt response
5. Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure
GFR
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Fomepizole
First order kinetics
6. Contraindications to use of atropine
Infants - closed angle glaucoma - prostatic hypertrophy
Nitrites
Pregnancy
Chemical esophagitis
7. Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis
Chloramphenicol
Albuterol
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Methotrexate
8. Example of three antidepressants that are indicated for obsessive compulsive disorder
Blocks peptidoglycan synthesis
Erythropoietin
Clomipramine - fluoxetine and fluvoxamine
Cocaine
9. Digoxin toxicity can be precipitated by
Hypokalemia
Amiodarone
Aminoglutethimide
Oxidation - reduction - hydrolysis
10. Scabicide organophosphate
LSD
Malathion
Phenylephrine
Infliximab
11. SE of procainamide
Lupus - like syndrome
Positive Comb's test - depression
Vancomycin - infusion at a slow rate and antihistamines
Theophylline
12. Amino acid derivative - active as an insulin secretagogue
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Prolongs QT interval
Increases concentration of Digoxin
Nateglinide
13. Irreversible condition resulting from the use of antipsychotics - reserpine at high doses - and MPTP (by- product of illicit meperidine analog)
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Gingival hyperplasia
Esmolol
Drug induced Parkinsonism
14. Agent used for closure of patent ductus arteriosus
Tissue plasmin activator
Indomethacin
PGE1
Warfarin (PT)
15. Antipsychotics that reduce positive symptoms only
Tetracaine and bupivacaine
Sodium channel blockers
Older antipsychotics
Carboplatin
16. Dopamine (DA) agonist (for Parkinson's disease) - used also for hyperprolactinemia
Beta blockers
Fluoxetine (Sarafem)
Bromocriptine
Bone marrow and teeth discoloration for children under 8 years of age
17. The most toxic organophosphate
Repaglinide
Citalopram and its metabolite escitalopram
Tizanidine
Parathion
18. Agent to treat torsades de pointes
Partial agonist
Magnesium sulfate
Irreversibly blocking cyclooxygenase
Sinus tachycardia and serious arrhythmias
19. Term for a narrow margin of safety
Steroids
Infliximab
Low therapeutic index
Ephedrine
20. These Beta blockers decrease aqueous secretion
Labetalol and carvedilol
Ethanol or fomepizole
Timolol (nonselective) - betaxolol (selective)
Fluoxetine
21. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively
Parathion
Leuprolide
Doxepin
Phentolamine
22. DOC for digoxin induced arrhythmias
Bone marrow and teeth discoloration for children under 8 years of age
Primaquine
Carbamazepine
Phenytoin
23. Selective alpha agonists that decreases aqueous secretion
Alkalinize urine - dialysis
Apraclonidine - brimonidine
Oxytocin
Erythropoietin
24. SelectiveB1 Receptor blockers that may be useful in treating patients even though they have asthma
GABA- related targets
Acebutolol - atenolol - esmolol - metoprolol
Clomipramine - fluoxetine and fluvoxamine
Hypertensive crisis
25. Common side effect of Rifampin
Dapsone - rifampin and clofazimine combination
Timolol
Red urine discoloration
Clozapine
26. Opioid antagonist that is given IV and had short DOA
Inhibit dihydropteroate synthase
Naloxone
Bromocriptine
Deferoxamine
27. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation
Methicillin - nafcillin - and dicloxacillin
Glucagon
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Theophylline
28. Period of time of therapy after which GC therapy will need to be tapered
Ezetimibe (Zetia)
5-7 days
Bradykinin and histamine
Spironolactone
29. Drug is used with testosterone for male fertility
Cholinesterase inhibitors
Rhabdomyolysis and Hepatotoxicity
Leuprolide
Phentolamine
30. Agents for reduction of postpartum bleeding
L- asparaginase
Oxytocin - ergonovine and ergotamine
Pamidronate - zoledronate - ibandronate
Mannitol
31. Antidepressant associated with neuroleptic malignant syndrome
Pulse therapy
Nicotine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Amoxapine
32. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
Selegiline
Flumazenil
Fluoxetine
Nitroglycerin sublingual tablets
33. Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Diazepam
Anterograde amnesia
Bleeding
34. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
ACE inhibitors
Succinylcholine
Ferrous sulfate
Orthostatic hypotension (especially with first dose) and reflex tachycardia
35. Prototypical drug is atropine
Midazolam
Salmeterol
Aspirin - Nitrates - CCB - and Beta blockers
Nonselective Muscarinic Antagonists
36. CCB are DOC for
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37. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Reduce the loss from area of injection
Hepatotoxicity
Acetazolamide
Paclitaxel (taxol)
38. Antipsychotic having the strongest autonomic effects
Hepatic toxicity
Opioid Analgesics
L- thyroxine (T4)
Thioridazine
39. Anti - biotic frequently used for chronic UTI prophylaxis
Alprazolam
sulfamethoxazole/ trimethoprim
Ethanol - fomepizole
First generation due to being more lipid - soluble
40. Drug causing depletion of substance P (vasodilator)
Sulfonamides
Capsaicin
First order kinetics
G- CSF (filgrastim) and GM- CSF (sargramostim)
41. Antidote used for anticholinergic poisoning
Physostigmine
Phenytoin
Agranulocytosis
Maintenance dose (Cp*(CL/F))
42. Antidote for thrombolytics
Carbamazepine
Morphine - methadone - meperidine - and fentanyl
Aminocaproic acid
Isoflurane
43. Side effects seen with tricyclic antidepressants
Dry cough - hyperkalemia
Fexofenadine - loratadine - and cetirizine
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Ticlopidine
44. Anti - seizure agent that induces formation of liver drug - metabolism enzymes - is teratogen and can cause craniofacial anomalies and spina bifida
Citalopram and its metabolite escitalopram
Carbamazepine
Ferrous sulfate
Pilocarpine - carbachol - physostigmine
45. Non - selective Beta - blocker also used for migraine prophylaxis
Propranolol
Fluoxetine
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Ketamine
46. Antidote used for acetaminophen (APAP) toxicity
Phenylephrine
100% O2 and hyperbaric O2
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
N- acetylcysteine (Mucomyst)
47. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation
Alpha1 agonists
Mivacurium
Allopurinol
Olanzapine - aripiprazole - and sertindole
48. Drug used in ergot alkaloids overdose - ischemia and gangrene
Dicyclomine - methscopolamine
Thyroid and steroid hormones
Nitroprusside
Atropine - homatropine - C1208 tropicamide
49. Used for hairy cell leukemia; it stimulates NK cells
Cyanocobalamin (Vit B12)
Interferon alpha
Potassium channel blockers
pregnancy and with K+
50. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
SSRIs
Degradation of fibrin clots and are administered IV
Affinity
Epinephrine