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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Anti - seizure drugs used also for pain of neuropathic orgin
Gabapentin
Spironolactone
Metrifonate
High therapeutic index
2. Alpha - glucosidase inhibitor associated with elevation of LFT's
Acarbose
Terbutaline
Selegiline
Desmopressin (DDAVP)
3. Major SE of insulin
Hypoglycemia
Gabapentin
Terfenadine and astemizole (have been removed from the market)
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
4. Chelating agent used in Wilson's disease
Dimercaprol
Penicillamine
Pre - existing cardiac or renal disease
Additive CNS depression
5. SE of Aspirin
GI bleeding
Infants
Echothiophate
LFT's
6. Antidote used for organophosphate/anticholinesterase poisoning
Calcium channel blockers
Inhibition of protein synthesis at the 50s subunit of ribosome
Atropine - pralidoxime (2- PAM)
Atrial fibrillation and CHF
7. SE of loop (furosemide) diuretics
Ascending pathways
Aztreonam
Hyperuricemia - hypokalemia and ototoxicity
Morphine and fentanyl
8. These Beta blockers decrease aqueous secretion
Acetazolamide
Hydralazine
Pregnancy
Timolol (nonselective) - betaxolol (selective)
9. Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso - enzyme.
Terfenadine and astemizole (have been removed from the market)
Combination oral contraceptives (OC)
block SLUD (salivation - lacrimation - urination - defecation
Insulin
10. Inhibit angiotensin - converting enzyme (ACE)
Flutamide (Eulexin)
Bradykinin
ACE inhibitors
ED50
11. 5HT-3 antagonist used in chemotherapeutic induced emesis
Atracurium
Infliximab
Ondansetron - granisetron - dolasetron and alosetron
Degradation of fibrin clots and are administered IV
12. Regimen used for non - Hodgkin's lymphoma
Fexofenadine - loratadine - and cetirizine
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Buspirone
Protamine sulfate
13. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea
Quetiapine
Zollinger - Ellison Syndrome
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
14. SE of hydralazine
Pre - existing cardiac or renal disease
Lupus - like syndrome
Clindamycin
Gingival hyperplasia
15. Interact with microtubules (but unlike vinca which prevent disassembly of tubules) - it stabilizes tubulin and cells remain frozen in metaphase
Noncompetitive antagonist
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Increases concentration of Digoxin
Paclitaxel (taxol)
16. Term for a narrow margin of safety
Bleomycin
Low therapeutic index
Temazpam - trizolam - flurazepam
Iron deiodinates thyroxine
17. Treatment for TB patients (think RIPE)
Aspirin
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Halothane
Insulin glargine
18. Proteins that prevent action of tumor necrosis factor alpha (TNF- alpha)
Hallucinations resembling psychosis
Nefazodone
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
Adalimumab - infliximab and etanercept
19. Major indication for H1 receptor antagonist
Use in IgE mediated allergic reaction
Sermorelin
Interferon alpha
Ketanserin cyproheptadine - and phenoxybenzamine
20. Newer atypical antipsychotic used for bipolar disorder - known to cause weight gain - and adversely affect diabetes
Olanzapine
Side - effect profile and prior pt response
Fluorocarbons and Industrial solvents
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
21. Aspirin reduces mortality in unstable angina by
Cocaine
Aldehyde dehydrogenase
LSD
Platelet aggregation inhibition
22. MOA of penicillin
Adrenal suppression and weaning slowly - respectively
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Protamine sulfate
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
23. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention
Carboplatin
Bethanechol
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Antipyretic and analgesic activity
24. Some cell cycle specific anti - cancer drugs
Most are thought to act at GABA- A receptor - chloride channel
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Mechlorethamine
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
25. Incidence of hyoglycemia with metformin
Adalimumab - infliximab and etanercept
None
Organic nitrites
Magnesium sulfate
26. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
Dry cough
Inhibit dihydropteroate synthase
Selegiline
REM is decreased
27. Anti - thyroid drugs
Pralidoxime
Benztropine
Thioamides - iodides - radioactive iodine - and ipodate
Calcium channel blockers
28. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Imipramine
Odansetron - granisetron
Demeclocycline
Cholinesterase regenerators - pralidoxime
29. Dose which is lethal to 50% of the population
LD50
Beta - blockers such as propranolol
Fluphenazine and haloperidol
Bupropion
30. SE of ergot alkaloids
Niacin
Diazepam
Glucagon
Hallucinations resembling psychosis
31. SE of tPA
Inhibit DNA gyrase
Esmolol
Cerebral hemorrhage
Chemical esophagitis
32. Drug increases the renal clearance hence decreases levels of lithium
Theophylline
Older antipsychotics
Warfarin (PT)
Tetracycline
33. Cutaneous flush and be reduced by pretreatment with
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Aspirin
Tamsulosin (Flomax)
Steroids
34. Products of Phase II conjugation
Glucuronate - acetic acid - and glutathione sulfate
Peripheral neuritis and hepatitis
Interleukin 11 (oprelvekin)
Geriatrics due to its CNS (depression) effects
35. MOA action of cromolyn
5- flouracil (5- FU)
Mast cell stabilizer
Methadone - followed by slow dose reduction
Fluoxetine (Sarafem)
36. Antidepressant inhibiting norepinephrine - serotonin - and dopamine reuptake
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Methadone - followed by slow dose reduction
Clindamycin
Venlafaxine
37. Causes bone marrow suppression
Pyridostigmine
Methotrexate
Cerebral hemorrhage
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
38. This beta blocker is the longest acting
Nadolol
Benztropine - trihexyphenidyl
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Dopamine blockade
39. Chronic orthostatic hypotension can be treated with
Midodrine
Baclofen
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Dantrolene
40. The most important sign of withdrawal syndrome
Disulfiram - like reaction
Excessive CNS stimulation (seizures)
Acyclovir; incorporated into viral DNA and chain termination
Risperidone
41. Selectivity of a drug for its receptor
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Specificity
Clopidogrel and ticlopidine
Ipratropium
42. Anti - seizure agent that exhibits non - linear metabolism - highly protein bound - causes fetal hydantoin syndrome - and stimulates hepatic metabolism
Deferoxamine
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Insulin
Phenytoin
43. Tolerance to all effects of opioid agonists can develop except
Miosis and constipation
Verapamil
Lorazepam - oxazepam - and temazepam
Methadone - followed by slow dose reduction
44. The ratio of the rate of elimination of a drug to its plasma concentration
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Tamsulosin (Flomax)
Clearance (CL)
Nandrolone - oxymetholone - and oxandrolone
45. Converted to more active form DHT by 5 alpha - reductase
Aplastic anemia and renal toxicity
block SLUD (salivation - lacrimation - urination - defecation
Testosterone
Dextromethorphan - Codeine
46. SelectiveB1 Receptor blockers that may be useful in treating patients even though they have asthma
Citalopram and its metabolite escitalopram
CNS stimulation; GI upset
Excessive hypotension and kidney failure
Acebutolol - atenolol - esmolol - metoprolol
47. These agents decrease blood flow or increase blood pressure - are local decongestants - and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion
Alpha1 agonists
Valproic acid
Cosyntropin
Aspirin irreversibly inhibits cyclooxygenase
48. Where are beta cells found in the pancreas?
Islets of Langerhans
Log - kill hypothesis
N- acetylcysteine
Propranolol
49. Drug notorious for causing pseudomembranous colitis
Labetalol and carvedilol
Clindamycin
Dexamethasone suppression test
Selegiline
50. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Timolol
Naloxone (IV) - naltrexone (PO)
Competitive antagonist
Sotalol