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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia
Esmolol
Risperidone
Thiopental
Phenylephrine
2. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure
Vancomycin
Venlafaxine
Hydroxychloroquine
Leuprolide
3. MOA of penicillin
Carbenicillin - piperacillin and ticarcillin
Lactic acidosis
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Opioid Analgesics
4. MOA for Ethosuximide
Low therapeutic index
Calcium channels
Megaloblastic anemia
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
5. COX 2 inhibitors may have reduced risk of
Gastric ulcers and GI Bleeding
Sermorelin
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Leucovorin
6. Anticoagulant of choice in pregnancy
Administration of Vit. B6 (pyridoxine)
Amiodarone
Heparin
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
7. This may antagonize activity of local anesthetics
Metrifonate
Hypercalcemia
lispro insulin - aspart insulin - glulisine insulin
Atropine - homatropine - C1208 tropicamide
8. MOA of class I A (eg. Procainamide) - class IB (eg. Lidocaine) - and class IC (eg. Flecainide) antiarrhythmics
Sodium channel blockers
Ultralente (humulin U)
Clomipramine - fluoxetine and fluvoxamine
Methicillin - nafcillin - and dicloxacillin
9. Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)
Demeclocycline
Bind ergosterol in fungal cell membrane
Flumazenil
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
10. SE of penicillamine
Aplastic anemia and renal toxicity
Patches - gum - nasal spray - psychotherapy - and bupropion
Buspirone
Gingival hyperplasia
11. Opioid antagonist that is given IV and had short DOA
Naloxone
Nandrolone - oxymetholone - and oxandrolone
Norepinephrine and serotonin
Dry cough - hyperkalemia
12. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)
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13. Toxicity caused by nitroprusside and treatment
Cyanide toxicity treated with sodium thiosulfate
Aplastic anemia and acute hepatic failure
Amphetamines
Nadolol
14. Drug is used with testosterone for male fertility
Levodopa
Aspirin - metoprolol
Folic acid
Leuprolide
15. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
Protamine sulfate
Etidronate
Increasing sodium excretion and decreases arterial and venous tone
L- dopa
16. Anti - seizure agent that exhibits non - linear metabolism - highly protein bound - causes fetal hydantoin syndrome - and stimulates hepatic metabolism
Pregnancy
Liver toxicity
Entacapone and Tolcapone
Phenytoin
17. HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
CNS depressants
Succinylcholine
Protease inhibitors
Repaglinide
18. 1st generation antihistamine that is least sedating
Streptokinase
Epinephrine
Chlorpheniramine or cyclizine
Aminoglutethimide
19. MOA of nateglinide
Insulin secretagogue - closes ATP- sensitive K+ channel
Interleukin 11 (oprelvekin)
Ketamine
Diazepam
20. LA causing methemoglobinemia
Clonazepam
Prilocaine
Excessive hypotension and kidney failure
Full agonist
21. Nonselective alpha - blocking drug - short acting and reversible - used for rebound HTN from rapid clonidine withdrawal - and Raynaud's phenomena
Regular (Humulin R)
Phentolamine
Leucovorin
Skeletal muscle tremor - tachycardia
22. Agent that is a partial agonist for the 5- HT1A receptor
Combination oral contraceptives (OC)
Ferrous sulfate
Penicillamine
Buspirone
23. MOA of nesiritide
Flutamide (Eulexin)
Increasing sodium excretion and decreases arterial and venous tone
Terbutaline
Additive CNS depression
24. Block glycoprotein IIb/IIIa involved in platelet cross - linking
Olanzapine - aripiprazole - and sertindole
Diazepam
CNS depressants
Abciximab - tirofiban and eptifibatide
25. Used for SIADH
Minimum alveolar anesthetic concentration (MAC)
Vasodilation
Demeclocycline
Apraclonidine - brimonidine
26. Acetaminophen only has
Quetiapine
Dobutamine and dopamine
Oral and transdermal forms of nitroglycerin
Antipyretic and analgesic activity
27. SE of Aspirin
GI bleeding
Bile acid - binding resins
Ticlopidine
Bradykinin
28. ACTH analog used for diagnosis of patients with corticosteroid abnormality
Peripheral neuritis and hepatitis
Block voltage - dependent sodium channels
Cosyntropin
Zolpidem
29. Most important potential SE of metformin
Lactic acidosis
Alkalinize urine - dialysis
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
Benztropine - trihexyphenidyl
30. Common toxicities of cisplatin
Serotonin syndrome
Nephro and ototoxicity
Kidney and liver toxicity - diarrhea
Tamsulosin
31. SE of Thiazolindinediones
Bone marrow and teeth discoloration for children under 8 years of age
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Low potency phenothiazines and ziprasidone
Acetazolamide
32. Anti - androgen used for prostate cancer
Flutamide (Eulexin)
Cyclobenzaprine
Low potency phenothiazines and ziprasidone
Carbamazepine - gabapentin - lamotrigine - and valproic acid
33. Exogenous insulin contains
Gabapentin
Little C- peptide
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Allopurinol
34. Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso - enzyme.
Increasing afterload and tissue perfusion declines
Cimetidine
Buprenorphine
Terfenadine and astemizole (have been removed from the market)
35. SE of INH
Red urine discoloration
Dantrolene
Lepirudin
Peripheral neuritis and hepatitis
36. State of analgesia and amnesia produced when fentanyl is used with droperidol and nitrous oxide
Neuroleptanesthesia
Epinephrine - dipivefrin
Cocaine 'super - speed'
Amiodarone
37. Toxicity of anticholinergics
Alkalinize urine - dialysis
Beta blockers
Sumatriptan - naratriptan - and rizatriptan
block SLUD (salivation - lacrimation - urination - defecation
38. Agent used in the treatment of alcoholism - if alcohol is consumed concurrently - acetaldehyde builds up and results in nausea - headache - flushing - and hypotension
Hypoglycemia
Labetalol and carvedilol
Disulfiram
G- CSF (filgrastim) and GM- CSF (sargramostim)
39. Reversal of blockade by neuromuscular blockers
Propranolol
Fomepizole
Oral
Cholinesterase inhibitors
40. Digoxin toxicity can be precipitated by
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Aldehyde dehydrogenase
Hypokalemia
DOM - STP - MDA - and MDMA 'ecstasy'
41. Atropine fever is the most dangerous effect and can be lethal in this population group
Cyclophosphamide
Infants
Cp
inhibits HMG COA reductase
42. Antidepressant also used for sleep that causes priapism
Trazodone
Calcium channel blockers
Naloxone (IV) - naltrexone (PO)
Nicotine
43. Window between therapeutic effect and toxic effect
Clomipramine - fluoxetine and fluvoxamine
Ipodate
Therapeutic index
Selective inhibitor of microtubule assembly
44. Antidote used for organophosphate/anticholinesterase poisoning
Ethosuximide and valproic acid
Atropine - pralidoxime (2- PAM)
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Nitroprusside
45. DOC for malignant hyperthermia by acting on the sacroplasmic reticulum or skeletal muscle
Vincristine
Dantrolene
Nitrous oxide
Inhibit DNA gyrase
46. Osmotic diuretic used to treat increased intracranial pressure
Mannitol
Fluphenazine and haloperidol
Tetracaine and bupivacaine
2 to 3 weeks
47. Prevents thrombosis in patients with artificial heart valve
Bile acid - binding resins
Dipyridamole
Decreases protein synthesis by inhibiting 30S ribosome
Nifurtimox
48. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis
Bleomycin
Acebutolol - atenolol - esmolol - metoprolol
NSAIDS
Gabapentin
49. Specific pharmacokinetic characteristic of amiodarone
Fluphenazine and haloperidol
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Prolonged half - life - up to six weeks
Bile acid - binding resins
50. Thiazolidinediones
Estogens increase maternal TBG
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Nesiritide (Natrecor)
6- mercaptopurine (6- MP)