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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Used for Cushing's syndrome (increased corticosteroid)
SEVERE myelosuppression
Liver toxicity - increased serum cholesterol
Dexamethasone suppression test
Imipramine
2. Antipsychotic having the strongest autonomic effects
Ototoxicity
Dimercaprol
Thioridazine
Lepirudin
3. Additive effects when Sedative - Hypnotics used in combination with these agents
Naltrexone
CNS depressants
Diphenoxylate - Loperamide
Dextromethorphan - Codeine
4. Antidepressant with MOA as alpha 2 antagonist - has effects on both 5- HT and NE - blocks histamine receptors - and is sedating
Mirtazapine
Gastric ulcers and GI Bleeding
Cerebral hemorrhage
Decrease arterial blood pressure
5. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Cosyntropin
Acebutolol - atenolol - esmolol - metoprolol
Ethanol
Citalopram and its metabolite escitalopram
6. Antipsychotics that reduce positive symptoms only
Ethanol or fomepizole
Amantadine
Haloperidol
Older antipsychotics
7. DOC to treat chemo - induced nausea and vomiting
Odansetron
Inhibit DNA gyrase
Acetazolamide
SEVERE myelosuppression
8. Treatment for opioid addiction
DOM - STP - MDA - and MDMA 'ecstasy'
Repaglinide
Naloxone
Methadone - followed by slow dose reduction
9. Chronic high dose abuse of nicotine leads to
Potency
Naltrexone
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
10. Inhibitor of leukotrienes (LTD4) receptors and used in asthma
Zafirlukast and montelukast
Vancomycin - infusion at a slow rate and antihistamines
Cocaine
Sulfonamides
11. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
Lithium
Severe hypertension
Hyperkalemia
Amoxicillin
12. Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because
Estogens increase maternal TBG
Cp
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Gingival hyperplasia - nystagmus - diplopia and ataxia
13. Anti - biotic frequently used for chronic UTI prophylaxis
Rhabdomyolysis and Hepatotoxicity
sulfamethoxazole/ trimethoprim
Epinephrine
Amoxapine
14. Antifungal agent used for inhibition of all gonadal and adrenal steroids
Spasmolytic drugs
Allopurinol
Amoxapine
Ketoconazole
15. Cause dizziness - tachycardia - hypotension - and flushing
Estogens increase maternal TBG
Organic nitrites
Tissue plasmin activator
Succinylcholine
16. Antiplatelet drug reserved for patients allergic to aspirin
Dextromethorphan - Codeine
Ticlopidine
Nonselective Muscarinic Antagonists
Dextroamphetamines and methamphetamine
17. Beta 1 agonist toxicity
Sinus tachycardia and serious arrhythmias
Streptomycin
Thrombocytopenic purpura - and CINCHONISM
Amphetamines
18. MOA of lovastatin (STATIN)
inhibits HMG COA reductase
Flumazenil
Tetracaine and bupivacaine
Excessive CNS stimulation (seizures)
19. Agent that inhibits alcohol dyhydrogenase and its clinical use
Ezetimibe (Zetia)
Regular (Humulin R)
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
CNS toxicity
20. Contraindications to use of atropine
Infants - closed angle glaucoma - prostatic hypertrophy
Aldehyde dehydrogenase
Morphine - methadone - meperidine - and fentanyl
Gynecomastia and hyperkalemia
21. Lacrimation - rhinorrhea - yawning - sweating - weakness - gooseflesh - nausea - and vomiting - tremor - muscle jerks - and hyperpnea are signs of this syndrome
Abstinence syndrome
Torsades de pointes
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Olanzapine - aripiprazole - and sertindole
22. Antidote used for cyanide poisoning
Naloxone
Valproic acid
Nitrites
Adrenal suppression and weaning slowly - respectively
23. SE of demeclocycline
Bone marrow and teeth discoloration for children under 8 years of age
Rescue therapy
Hypertension
Hypoglycemia
24. H1 blocker that is also a serotonin antagonist
Cyproheptadine
Decrease arterial blood pressure
Penicillamine
Atrial fibrillation and CHF
25. Alkylating agent - vesicant that causes tissue damage with extravasation
Mechlorethamine
Elderly patients
Amphetamines
sodium polystyrene sulfonate (Kayexalate)
26. Antipsychotic having the weakest autonomic effects
Haloperidol
Topical mupirocin (Bactroban)
Sodium channel blockade
Muscarinic blockers
27. Interaction with this drug requires dose reduction of 6- MP
Hydration and mercaptoethanesulfonate (MESNA)
Reduce inhibition - suppress anxiety - and produce relaxation
Allopurinol
B- blockers
28. Major indication for H1 receptor antagonist
Use in IgE mediated allergic reaction
Alpha1 agonists
Tamsulosin (Flomax)
Overdose of opioids
29. What do alpha cells in the pancreas produce?
GFR
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Clozapine
Glucagon
30. Reduced seizure threshold
Amoxapine
Low - potency typical antipsychotics and clozapine
Loading dose (Cp*(Vd/F))
Primaquine
31. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Clonazepam
Ethanol
Alprazolam and Clonazepam
32. Atropine fever is the most dangerous effect and can be lethal in this population group
Spasmolytic drugs
Ethanol
Infants
Low therapeutic index
33. Captopril and enalapril (- OPRIL ending) are
Inhibition of protein synthesis at the 50s subunit of ribosome
ACE inhibitors
Cocaine and benzocaine
Methotrexate
34. Leads to respiratory depression progressing to coma and death
Ketanserin cyproheptadine - and phenoxybenzamine
Aminocaproic acid
Ethosuximide and valproic acid
Overdose of opioids
35. DOC for paroxysmal supraventricular tachycardia; has high efficacy and short duration of action
Block voltage - dependent sodium channels
Tamsulosin
Adenosine
Calcium
36. Inducers of Cytochrome P450 (CYP450)
Procarbazine
Dobutamine and dopamine
Interleukin 11 (oprelvekin)
Barbiturates - phenytoin - carbamazepine - and rifampin
37. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Ketamine
Dimercaprol
Estrogen
Bromocriptine
38. Major route of elimination for Lithium
Bioavailability (F)
Sumatriptan
Nandrolone - oxymetholone - and oxandrolone
Kidneys
39. MOA of AGI's
Gastric ulcers and GI Bleeding
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Ganciclovir
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
40. Agent used for acute muscle spasm
Cyclobenzaprine
Apraclonidine - brimonidine
Nitroprusside
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
41. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively
Chlorpheniramine or cyclizine
Chlorpropamide
Vasodilation
Leuprolide
42. Anti - seizure medication also used in the prevention of migraines
5-7 days
Dexamethasone suppression test
Sumatriptan
Valproic acid
43. SE for ticlopidine
Valproic acid and Phenytoin
Vitamin B12
Neutropenia and agranulocytosis
Celecoxib and rofecoxib
44. Dose may need to be increased during pregnancy or with Ocs due to increased TBG in plasma
Thyroxine
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Somatrem
High therapeutic index
45. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention
REM is decreased
Bethanechol
Prilocaine
Efficacy
46. Anti - malarial drug used in rheumatoid arthritis (RA)
Hydroxychloroquine
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Gynecomastia and hyperkalemia
Carbamazepine
47. Rate limiting step of alcohol metabolism
Carboplatin
Aldehyde dehydrogenase
Phentolamine
Carmustine (BCNU) and lomustine (CCNU)
48. Most common SE of fibrates
Pyridostigmine
Cerebral hemorrhage
Nausea
Malathion
49. Decreases liver triglycerol synthesis
Acute intermittent porphyria
Atropine - homatropine - C1208 tropicamide
Niacin
Phenobarbital
50. Treatment of motion sickness
Dipyridamole
Allopurinol
Scopolamine - meclizine
Nortriptyline - Desipramine