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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Rapid acting insulins that do not self - aggregate
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Testosterone
lispro insulin - aspart insulin - glulisine insulin
Dantrolene
2. MOA of thiazide diuretics
Inhibit Na+/Cl - cotransport
Sotalol
Thyroxine
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
3. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
Sumatriptan - naratriptan - and rizatriptan
Succinylcholine
Amrinone and milrinone
Isoflurane
4. SE of HMG COA reductase inhibitors
Rhabdomyolysis and Hepatotoxicity
Vancomycin
Miosis and constipation
Mannitol
5. SE of Amiodarone
Hydroxychloroquine
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Oral
Hydralazine
6. Site of action for zaleplon and zolpidem
Uterine contractions
Cyanide toxicity treated with sodium thiosulfate
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Benzodiazepines and calcium channel blockers
7. Anticoagulant of choice in pregnancy
Amiodarone
Heparin
Estrogen
Oral
8. Antidepressant associated with neuroleptic malignant syndrome
Benztropine
Kidney and liver toxicity - diarrhea
SSRIs
Amoxapine
9. 5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease
Hepatic toxicity
Hepatic enzymes
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Dolasetron
10. SSRI indicated for premenstrual dysphoric disorder
Na+/K+ exchange
Heparin induced thrombocytopenia (HIT)
Fluoxetine (Sarafem)
Decrease arterial blood pressure
11. Drug causing depletion of substance P (vasodilator)
Caffeine
Hydralazine
Reducing progression of heart failure (never use in acute heart failure)
Capsaicin
12. Antidote used for anticholinergic poisoning
Physostigmine
100% O2 and hyperbaric O2
Ketanserin cyproheptadine - and phenoxybenzamine
Nonselective Muscarinic Antagonists
13. DOC for digoxin induced arrhythmias
Phenytoin
Naltrexone
Chlorpropamide - tolbutamide - tolazamide - etc.
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
14. Regimen used for non - Hodgkin's lymphoma
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Indomethacin
Respiratory failure
Spironolactone
15. Oral contraceptive available in a transdermal patch
Amiodarone
Ortho - Evra
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Buspirone
16. Common side effect of hypnotic agents
Procarbazine
Oxytocin
Sedation
Rifampin
17. MOA for benzodiazepines and barbiturates
Loading dose (Cp*(Vd/F))
Letrozole - anastrozole
None
GABA- related targets
18. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia
Drug induced Parkinsonism
Phenylephrine
Erythromycin
Liver toxicity
19. Nonselective alpha agonists that increases outflow - probably via the uveoscleral veins
Topical mupirocin (Bactroban)
Low therapeutic index
Epinephrine - dipivefrin
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
20. Treatment for TB patients (think RIPE)
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Interleukin 11 (oprelvekin)
Diclofenac - ketoralac
100% O2 and hyperbaric O2
21. Block cardiac adverse effects of thyrotoxicosis such as tachycardia - inhibits the conversion of T4 to T3
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Beta - blockers such as propranolol
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Serotonin syndrome
22. Pneumonic for 3 zones of adrenal cortex
ACE inhibitors
Nephrotoxicity
Dimercaprol
GFR
23. Pungent inhaled anesthetic which leads to high incidence of coughing and vasospasm
high doses
Diethylstilbestrol (DES)
Prostaglandin PGF2a
Desflurane
24. Most important toxic effects of most local anesthetics
Tertiary amines
Mifepristone
CNS toxicity
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
25. Opioid antagonist that is given orally in alcohol dependency programs
Naltrexone
Propranolol
Dimercaprol - EDTA
Bromocriptine
26. GABA agonist in the spinal cord
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
Liver toxicity - increased serum cholesterol
Baclofen
Nonselective Muscarinic Antagonists
27. Anti - seizure medication also used in the prevention of migraines
DOM - STP - MDA - and MDMA 'ecstasy'
Nephro and ototoxicity
Valproic acid
Amantadine
28. Used intranasally and decreases bone resorption
GFR
Dimercaprol - EDTA
Calcitonin (salmon prep)
Haloperidol or pimozide
29. State of analgesia and amnesia produced when fentanyl is used with droperidol and nitrous oxide
Nortriptyline - Desipramine
Neuroleptanesthesia
LSD
Log - kill hypothesis
30. MOA of tetracycline
Radioactive iodine
Decreases protein synthesis by inhibiting 30S ribosome
Affect calcium - potassium - and sodium channels
GI bleeding
31. Long acting beta 2 agonist used in asthma
Sedation
Salmeterol
Neutropenia and agranulocytosis
Hypoglycemia
32. Well - tolerated and are first - line antidepressants
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33. Side effect of sotalol
Thyroid and steroid hormones
prolongs QT and PR interval
Low therapeutic index
Gabapentin
34. These LA's have surface activity
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
5- flouracil (5- FU)
Cocaine and benzocaine
Aspirin - Nitrates - CCB - and Beta blockers
35. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
Nefazodone
SSRIs
Cholinesterase inhibitors
Succinylcholine
36. Heparin (PTT) increases activity of
CNS depressants
Propranolol
Antithrombin 3
Inhibit DNA gyrase
37. MOA of sildenafil (Viagra)
Beta blockers
Prinzmetal's angina
Arteries and veins
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
38. Window between therapeutic effect and toxic effect
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Beta -1 selective blockers
Therapeutic index
Hyperkalemia
39. SE of heparin
SSRI's - bupropion - and venlafaxine
Alprostadil
Heparin induced thrombocytopenia (HIT)
Doxepin
40. Incidence of hyoglycemia with metformin
None
lispro insulin - aspart insulin - glulisine insulin
Alkalinize urine - dialysis
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
41. MOA of loop diuretics
Flumazenil
Mannitol
inhibits Na+/K+/2Cl - cotransport
high doses
42. Drug used in cancer therapy causes Cushing - like symptoms
Phentolamine
Cutaneous flush
Prednisone
Liver toxicity
43. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Deferoxamine
Interleukin 11 (oprelvekin)
Epinephrine
nephro and ototoxicity
44. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
Flumazenil
Dextromethorphan - Codeine
Sermorelin
Carbamazepine
45. Concurrent use of fibrates and statins increases risk of
Rhabdomyolysis
Low potency phenothiazines and ziprasidone
Liver toxicity - increased serum cholesterol
Primaquine
46. Agent to treat hypochromic microcytic anemias
Pulmonary embolism and DVT
Ferrous sulfate
Flunitrazepam (rohypnol)
Capsaicin
47. Antivirals that are teratogens
Delavirdine - efavirenz - and ribavirin
Efficacy
Lithium
Platelet aggregation inhibition
48. Barbiturates may precipitate this hematologic condition
Acute intermittent porphyria
Noncompetitive antagonist
Cytomel
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
49. Longer acting local anesthetics which are less dependent on vasoconstrictors
Tetracaine and bupivacaine
Buspirone
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
50. NSAID available orally - IM and ophthalmically
Ketoralac
Bradykinin
Gingival hyperplasia
Leuprolide