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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The most frequent cause of acute deaths in cholinesterase inhibitor toxicity






2. Diuretic used to antagonize aldosterone receptors






3. SE of nesiritide






4. A hormone whose MOA utilizes transmembrane receptors






5. Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA






6. 5HT-3 antagonist used in chemotherapeutic induced emesis






7. MOA for benzodiazepines and barbiturates






8. Ultra long acting insulin - has over a day duration of action






9. Atropine fever is the most dangerous effect and can be lethal in this population group






10. Anti - androgen used for hirsutism in females






11. Treatment of atropine overdose and glaucoma (because lipid soluable). Enters the CNS rapidly and has a stimulant effect - which may lead to convulsions






12. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)






13. 'Date rape drug'






14. Chelating agent used in Wilson's disease






15. SE of long term (>5 days) corticosteroid therapy and remedy






16. Treatment of withdrawal syndrome involves






17. Toxicity caused by nitroprusside and treatment






18. Plasma concentration of a drug at a given time






19. These LA's have surface activity






20. SE of CCB






21. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion






22. MOA of nystatin






23. SE of hydroxychloroquine






24. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis






25. Dose which is lethal to 50% of the population






26. Antidote used for anticholinergic poisoning






27. Reversal of blockade by neuromuscular blockers






28. Toxicity of anticholinergics






29. Peakless ling acting insulin






30. These Beta blockers decrease aqueous secretion






31. MOA of drug or foods (grapefruit juice) that increase statin effect






32. 2nd generation antihistamines






33. These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB)






34. Population group especially sensitive to side effects of antidepressants






35. One depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis - causes muscle pain postoperatively and myoglobinuria may occur






36. Opioid associated with respiratory depression - but is used in high risk patients who may not survive full general anesthetia






37. Class of drugs with ability to decrease the maximal response to an agonist






38. This may antagonize activity of local anesthetics






39. What do alpha cells in the pancreas produce?






40. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis






41. Moderate opioid agonists






42. Anti - rheumatic agent also used for Chron's disease






43. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism






44. Fibrates (gemfibrozil) increase activity of






45. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine






46. This parenteral beta blocker is a short acting (minutes)






47. DOC for RSV






48. TCA used in obsessive compulsive disorder (OCD) - most significant of TCA's for risk of seizure - weight gain - and neuropsychiatric signs and symptoms






49. Microtubule inhibitor that causes peripheral neuropathy - foot drop (eg. ataxia) - and 'pins and needles' sensation






50. Antidote used for opioid toxicity







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