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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Rate limiting step of alcohol metabolism






2. Weak opioid agonist - poor analgesic - its overdose can cause severe toxicity including respiratory depression - circulatory collapse - pulmonary edema - and seizures






3. Non - selective Alpha1blockers use to treat pheochromocytoma






4. MOA of Cardiac glycosides (eg. digoxin)






5. Time it takes for amount of drug to fall to half of its value; this is a constant in first order kinetics (majority of drugs)






6. Lactam that can be used in PCN allergic patients






7. Drug is used with testosterone for male fertility






8. Benzodiazepine that undergo extrahepatic conjugation (which are useful in older or hepatically impaired)






9. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension






10. DOC for status epilepticus






11. ADH agonist used for pituitary diabetes insipidus






12. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents






13. Aromatase inhibitor used in breast cancer






14. Agent with long duration of action and is most likely to cause histamine release






15. SE of heparin






16. Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia






17. Antibiotic causing red - man syndrome - and prevention






18. Used intravenously for acute arrhythmias during surgery






19. Agent used neutropenia especially after chemotherapy






20. Thioamide less likely to cross placenta - inhibits peripheral conversion of T4 to T3 in high doses - and should be used with extreme caution in pregnancy






21. Antidote used for organophosphate/anticholinesterase poisoning






22. Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis






23. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression






24. Antidote for hyperkalemia






25. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine






26. Antipsychotic having the strongest autonomic effects






27. Meningitis prophylaxis in exposed patients






28. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property






29. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress






30. Site of action of thiazide diuretics






31. H2 blocker that causes the most interactions with other drugs






32. Anti - seizure agent that induces formation of liver drug - metabolism enzymes - is teratogen and can cause craniofacial anomalies and spina bifida






33. Major route of elimination for Lithium






34. SE of penicillamine






35. Major SE of zileuton






36. Reason ergot alkaloids are contraindicated in pregnancy






37. Major SE of insulin






38. Most dangerous of the currently popular hallucinogenic drugs - OD leads to nystagmus - marked hypertension - and seizures - presence of both horizontal and vertical nystagmus is pathognomonic






39. Sulfonylurea Not recommended for elderly because of very long half life






40. The elimination of drug that occurs before it reaches the systemic circulation






41. Antidote used for iron salt toxicity






42. Antidote used in poisonings: copper (Wilson's disease) - lead - mercury - and arsenic






43. SE of Aspirin






44. Laboratory value required to be monitored for patients on valproic acid

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45. Cardioselective Beta 1- blockers






46. Tolerance is marked and abstinence syndrome occurs






47. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients






48. MOA of neuroleptics






49. New class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins






50. The fraction of administered dose of a drug that reaches systemic circulation