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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Longer acting Beta 2 agonist is recommended for prophylaxis of asthma
Prostaglandin PGF2a
Salmeterol
Corticosteroids
Heroin - morphine - oxycodone - meperidine and fentanyl
2. DOC for influenza A
Dopamine
Amantadine
Dimercaprol
Megaloblastic anemia
3. Agent used for megaloblastic anemia (but does Not reverse neurologic symptoms) and decrease neural tube defects during pregnancy
Urinary acidification and activated charcoal or continual nasogastric suction
Inhibit DNA gyrase
Folic acid
Phenytoin
4. Side effects frequently seen with SSRIs
Clomiphene and tamoxifen
CNS stimulation; GI upset
Calcium
Ipratropium
5. Example of three antidepressants that are indicated for obsessive compulsive disorder
Maprotiline
Nicotine
Clomipramine - fluoxetine and fluvoxamine
Tubocurarine
6. Benzodiazepines that are the most effective in the treatment of panic disorder
Ezetimibe (Zetia)
Beta - blockers such as propranolol
Alprazolam and Clonazepam
Cyproterone acetate
7. MOA of corticosteroids
pregnancy and with K+
Tamoxifen
inhibit phospholipase A2
Clomiphene and tamoxifen
8. Cephalosporin causes kernicterus in neonates
Oxybutynin - dicyclomine
Diclofenac - ketoralac
Marijuana
Ceftriaxone or cefuroxime
9. Structurally related to acetylcholine - used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation
Neuromuscular blocking drugs
Nitrous oxide
Pulmonary embolism and DVT
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
10. H2 blocker that causes the most interactions with other drugs
Cimetidine
Ipratropium
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Dicyclomine - methscopolamine
11. Irreversible - nonselective COX inhibitor
Cefixime (3rd) generation
Aspirin
Increased thromboembolic events
Timolol
12. MOA of metformin
Hypoglycemia
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Tetracycline
Normal C- peptide
13. Used in pediatrics to maintain patency of ductus arteriosis
PGE1
Celecoxib and rofecoxib
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
SEVERE myelosuppression
14. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism
Iodide salts
Liver toxicity
Epinephrine - dipivefrin
Liver enzyme INDUCTION
15. Diuretic used to treat primary aldosteronism
Hypoglycemia
Lupus - like syndrome
Alprazolam
Spironolactone
16. Drug used for African sleeping sickness
Nateglinide
Suramin
prolongs QT and PR interval
Glucagon
17. Common mechanism by which overdose result in death
Na+/K+ exchange
Potency
Deferoxamine
Depression of medullary and cardiovascular centers
18. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
Cimetidine
Succinylcholine
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Desmopressin (DDAVP)
19. Anti - estrogen used for estrogen receptor + breast cancer
Liver toxicity
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Heparin induced thrombocytopenia (HIT)
Tamoxifen
20. Anti - viral agents associated with Stephen Johnson syndrome
Nevirapine - amprenavir
Nitroglycerin sublingual tablets
Spironolactone
Prolonged half - life - up to six weeks
21. Agent that inhibits alcohol dyhydrogenase and its clinical use
SSRIs
Ethanol - fomepizole
Dicyclomine - methscopolamine
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
22. Antidepressant also used for sleep that causes priapism
Flutamide (Eulexin)
Trazodone
hydroxyzine (Atarax)
inhibits Na+/K+/2Cl - cotransport
23. Benzodiazepine used for anxiety
Beta -1 selective blockers
Cevimeline
Alprazolam
Methadone
24. Drug used for MRSA
Liver toxicity
Block voltage - dependent sodium channels
IV administration
Vancomycin
25. Anti - progesterone used as abortifacient
Terbutaline
Mifepristone (RU-486)
Tinnitus - GI bleeding
Glargine (Lantus) - detemir
26. Difference between aspirin and other NSAIDS
Glucagon
Prilocaine
Chemical esophagitis
Aspirin irreversibly inhibits cyclooxygenase
27. Drug that selectively inhibits COX 2
Celecoxib and rofecoxib
Dry cough
Megaloblastic anemia
Hallucinations resembling psychosis
28. Toxicity of organophosphate:
Verapamil
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
hydroxyzine (Atarax)
29. These agents are CNS depressants
Amphetamines
Ethanol - Barbiturates - and Benzodiazepines
Propranolol
Kidneys
30. Patients being treated with lithium - who are dehydrated - or taking diuretics concurrently - could develop
Lithium toxicity
Methotrexate
Atenolol - acebutolol - and metoprolol
Digibind
31. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Acetazolamide
Citalopram and its metabolite escitalopram
Phenobarbital
Regular (Humulin R)
32. Warfarin is contraindicated in
Sedation
Bleeding
Pregnancy
Minocycline
33. Contraindications to use of atropine
CNS depressants
Citalopram and its metabolite escitalopram
Infants - closed angle glaucoma - prostatic hypertrophy
Dexrazoxane
34. DOC for herpes and its MOA
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Imipramine
Acyclovir; incorporated into viral DNA and chain termination
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
35. Drugs available in combination with metformin
Liver toxicity - increased serum cholesterol
Glyburide - glipizide - and rosiglitazone
2 to 3 weeks
ACE inhibitors
36. MOA of class III antiarrhythmics
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Potassium channel blockers
Acetazolamide
CNS stimulation; GI upset
37. Agents having active metabolites - long half lives - and a high incidence of adverse effects
Arteries and veins
N- acetylcysteine (Mucomyst)
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
38. Used intravenously for acute arrhythmias during surgery
EOS
Acetazolamide
Testosterone
Esmolol
39. Antidote used for warfarin toxicity
Vitamin K and Fresh frozen plasma (FFP)
Magnesium sulfate
Propranolol
Cyanide toxicity treated with sodium thiosulfate
40. Some of SSRIs' therapeutic effects beside depression
Prostaglandin PGF2a
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Insulin glargine
prolongs QT and PR interval
41. MOA of quinolones
Labetalol and carvedilol
Side - effect profile and prior pt response
Inhibit DNA gyrase
Iron deiodinates thyroxine
42. SE of hydroxychloroquine
Retinal destruction and dermatitis
Erythromycin
Oxybutynin - dicyclomine
Dicyclomine - methscopolamine
43. Reason benzos are used cautiously in pregnancy
B- blockers
Prilocaine
Calcium channel blockers
Ability to cross the placenta
44. Major SE of zileuton
Liver toxicity
Nateglinide
St. Anthony's Fire
Tricyclic antidepressants (TCA)
45. Drug of choice for generalized anxiety disorder - Not effective in acute anxiety
Betamethasone and dexamethasone
Mirtazapine
Buspirone
Atropine
46. Antidote for salicylate intoxication
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Glucagon
Inhibits osteoclast bone resorption
Alkalinize urine - dialysis
47. Major indication for H1 receptor antagonist
Sumatriptan
Use in IgE mediated allergic reaction
Log - kill hypothesis
Hypoglycemia
48. Class of drugs whose MOA utilizes ligand gated ion channels
Paclitaxel (taxol)
Neutro - leuko and thrombocytopenia
Benzodiazepines and calcium channel blockers
Patches - gum - nasal spray - psychotherapy - and bupropion
49. Triptan available in parenteral and nasal formulation
Fomepizole
Sumatriptan
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Hypokalemia
50. Long acting glucocorticoids
Metronidazole
Betamethasone and dexamethasone
Prazosin - terazosin - doxazosin
Protamine sulfate