Test your basic knowledge |

USMLE/COMLEX Step 1 Pharmacology One Liners

Subjects : health-sciences, usmle-step-1, comlex

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. W/D from this drug causes anxiety and mental discomfort
Work at early distal convoluted tubule
Cardiac anomalies and is contraindicated in pregnancy or lactation
Nicotine
Dantrolene

2. Orthostatic hypotension and QT prolongation
Ethinyl estradiol and mestranol
Thick ascending limb
Low potency phenothiazines and ziprasidone
Cyproheptadine

3. Antidote for acetaminophen toxicity
Cephalosporins
N- acetylcysteine
Albuterol
Log - kill hypothesis

4. Thioamide agents used in hyperthyroidism
Risperidone
Ability to cross the placenta
Reduce inhibition - suppress anxiety - and produce relaxation
Methimazole and propylthiouracil (PTU)

5. These beta blockers are less lipid soluble
Leucovorin
Overdose of opioids
Acebutolol and atenolol
Ipratropium

6. Toxicity of amphotericin
Nephrotoxicity
Alprazolam and Clonazepam
Entacapone and Tolcapone
5-7 days

7. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
Full agonist
L- dopa
Respiratory failure
Tolerance

8. Chronic orthostatic hypotension can be treated with
Warfarin (PT)
Midodrine
Aldehyde dehydrogenase
ACE inhibitors

9. MOA for benzodiazepines and barbiturates
Sermorelin
Ganciclovir
GABA- related targets
Older antipsychotics

10. SE of beta blockers
PGE1
Salmeterol
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Fluoxetine

11. Drugs that can be used for infantile spasms
Methoxyflurane
Corticosteroids
G- CSF (filgrastim) and GM- CSF (sargramostim)
Acid reflux disease - duodenal ulcer and peptic ulcer disease

12. Agent that is a partial agonist for the 5- HT1A receptor
Agranulocytosis
Buspirone
Carbidopa
Raloxifene (SERM- selective estrogen receptor modulator)

13. Long acting sympathomimetic - sometimes used to improve urinary continence in children and elderly with enuresis
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Ephedrine
Bromocriptine
Vitamin B12

14. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Olanzapine - aripiprazole - and sertindole
pregnancy and with K+
Zero order kinetics

15. Non - selective Alpha1blockers use to treat pheochromocytoma
Dapsone - rifampin and clofazimine combination
Phenoxybenzamine
Mannitol
DOM - STP - MDA - and MDMA 'ecstasy'

16. Major SE of insulin
Chlorpropamide
Steroids
Partial agonist
Hypoglycemia

17. SE of nesiritide
Dry cough
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Halothane and methoxyflurane
Excessive hypotension and kidney failure

18. Atropine fever is the most dangerous effect and can be lethal in this population group
Infants
Fomepizole
Cytomel
Olanzapine

19. MOA of Cardiac glycosides (eg. digoxin)
Acarbose - miglitol
Halothane
Volume of distribution (VD)
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase

20. Use of this opioid with MAOI can lead to hyperpyrexic coma - and with SSRI's can lead to serotonin syndrome
Risperidone
Sodium channel blockade
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
Meperidine

21. Chelating agent used in Wilson's disease
Penicillamine
Mast cell stabilizer
Calcium
Albuterol

22. DOC for paroxysmal supraventricular tachycardia; has high efficacy and short duration of action
Adenosine
Oxytocin
Diazepam
Cholinesterase inhibitors

23. Intermediate acting glucocorticoids
Glucagon
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Nitrous oxide
Acetazolamide

24. SE of AGI's
Lispro (Humalog) - aspart - glulisine
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Buspirone
Drug induced Parkinsonism

25. Selective alpha agonists that decreases aqueous secretion
Apraclonidine - brimonidine
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Dry cough
Calcium channels

26. Mast cells to reduce release of hisamine and inflammatory mediators
Nortriptyline - Desipramine
Terfenadine and astemizole (have been removed from the market)
Oral and transdermal forms of nitroglycerin
Epinephrine

27. Pyrimidine analog that causes 'Thymine - less death' given with leucovorin rescue
5- flouracil (5- FU)
Nateglinide
First generation due to being more lipid - soluble
Nevirapine - amprenavir

28. SE of amrinone
Amoxicillin
Thrombocytopenia
Beta1 agonists
Most are thought to act at GABA- A receptor - chloride channel

29. Aspirin reduces mortality in unstable angina by
Metrifonate
Iodide salts
Infants
Platelet aggregation inhibition

30. MOA of class I A (eg. Procainamide) - class IB (eg. Lidocaine) - and class IC (eg. Flecainide) antiarrhythmics
Sodium channel blockers
Hyperuricemia - hypokalemia and hyperglycemia
Pilocarpine - carbachol - physostigmine
Cerebral hemorrhage

31. Antidote used for methanol and ethylene glycol
Degradation of fibrin clots and are administered IV
Ethanol or fomepizole
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
Tizanidine

32. Most dangerous of the currently popular hallucinogenic drugs - OD leads to nystagmus - marked hypertension - and seizures - presence of both horizontal and vertical nystagmus is pathognomonic
First order kinetics
Levodopa
PCP
Hepatotoxicity

33. Ultra long acting insulin - has over a day duration of action
Glargine (Lantus) - detemir
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Infants - closed angle glaucoma - prostatic hypertrophy
Pralidoxime - atropine

34. Second generation sulfonylurea
Pamidronate - zoledronate - ibandronate
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
N- acetylcysteine (Mucomyst)
Glyburide - glipizide - glimepiride - etc.

35. Carbonic anhydrase inhibitor
Glyburide - glipizide - and rosiglitazone
Raloxifene (SERM- selective estrogen receptor modulator)
Thyroxine
Acetazolamide

36. HIV med used to reduce transmission during birth
Beta -1 selective blockers
Yohimbine
Phenytoin
AZT (zidovudine)

37. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Ethanol
Fluoxetine
Pralidoxime
Prolongs QT interval

38. Treatment with cancer chemotherapy at high doses every 3-4 weeks - too toxic to be used continuously
Sedation
Regular (Humulin R)
Enflurane and halothane
Pulse therapy

39. Increased risk of developing cataracts
Acarbose
N- acetylcysteine
Quetiapine
Sulfonamides

40. Causes acne - premature closure of epiphyses - masculinization in females - hepatic dysfunction - MI - and increases in libido and aggression
Insulin release from pancreas by modifying K+ channels
Dimenhydrinate - meclizine - and other 1st generation
DOM - STP - MDA - and MDMA 'ecstasy'
Steroids

41. Dose which is lethal to 50% of the population
Hydration and mercaptoethanesulfonate (MESNA)
LD50
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Naltrexone

42. Where are beta cells found in the pancreas?
Liver toxicity - increased serum cholesterol
Islets of Langerhans
Nephrotoxicity
Iodide salts

43. Side effects occuring in antipsychotics that block dopamine
Albuterol
Classic
Metronidazole
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain

44. Ability to bind reversibly to the same site as the drug and without activating the effector system
Increases concentration of Digoxin
Competitive antagonist
Venlafaxine
Ganciclovir - zidovudine - saquinavir - and interferon

45. Exogenous insulin contains
Esmolol
Tertiary amines
Ethosuximide and valproic acid
Little C- peptide

46. Long acting insulin
Oxybutynin - dicyclomine
Chlordiazepoxide and Diazepam
Naloxone
Ultralente (humulin U)

47. H2 blocker that causes the most interactions with other drugs
Cimetidine
Nitrites
Steady state
Dimercaprol - EDTA

48. Cephalosporin causes kernicterus in neonates
Liver toxicity - increased serum cholesterol
Salmeterol
Ceftriaxone or cefuroxime
EOS

49. Aminoglycoside that is least ototoxic
Bioavailability (F)
Epinephrine
Zafirlukast and montelukast
Streptomycin

50. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Epinephrine
Hepatotoxicity
Lithium