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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. DOC for paroxysmal supraventricular tachycardia (PSVT)
Adenosine
Low therapeutic index
Bromocriptine
Alpha1 agonists
2. This agent cause increased aqueous outflow
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Prostaglandin PGF2a
Maprotiline
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
3. State of analgesia and amnesia produced when fentanyl is used with droperidol and nitrous oxide
Neuroleptanesthesia
Methotrexate
Hypercalcemia
Flumazenil
4. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)
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5. Nitrate used to prevent further attacks
Tertiary amines
Phentolamine
Oral and transdermal forms of nitroglycerin
CNS stimulation; GI upset
6. Amphetamine agents
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Adenosine
Dextroamphetamines and methamphetamine
Zolpidem
7. Examples of alpha - glucosidase inhibitors (AGI)
Apraclonidine - brimonidine
Acarbose - miglitol
Dimercaprol
Verapamil
8. SE for Felbamate
Xanthine oxidase
Vitamin D
Aplastic anemia and acute hepatic failure
Dobutamine
9. Inversely related to potency of anesthetics
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
Minimum alveolar anesthetic concentration (MAC)
Amphetamines
Folic acid
10. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Potassium channel blockers
Calcium channel blockers
Insulin
Cholinesterase regenerators - pralidoxime
11. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
Decreases protein synthesis by inhibiting 30S ribosome
Levodopa
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Caffeine
12. Agent used to treat chronic gout by increasing uric acid secretion and excretion
Venlafaxine
Meperidine
lispro insulin - aspart insulin - glulisine insulin
Probenecid and sulfinpyrazone
13. SE of both warfarin and heparin
Ketamine
Bleeding
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Megaloblastic anemia
14. Epinephrine is often mixed with a local anesthetic to
Reduce the loss from area of injection
Zolpidem - zaleplon
Dry cough
Phenoxybenzamine
15. Side effect of Mitomycin
SEVERE myelosuppression
Meperidine
Decrease arterial blood pressure
Increasing afterload and tissue perfusion declines
16. The most important sign of withdrawal syndrome
Excessive CNS stimulation (seizures)
Salmeterol
Uterine contractions
Bromocriptine
17. Non - steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
Mast cell stabilizer
Diethylstilbestrol (DES)
Selegiline
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
18. Mineralocorticoids
Fludrocortisone and deoxycorticosterone
Lispro (Humalog) - aspart - glulisine
Decreased micro and macro vascular disease
Nephro and ototoxicity
19. Atypical antipsychotic causing high prolactin levels
Kidneys
Esmolol
Inhibit Cytochrome P450 3A4
Risperidone
20. Anti - microbials that cause hemolysis in G6PD- deficient patients
Celecoxib and rofecoxib
Hydroxychloroquine
Sulfonamides
Prazosin - terazosin and doxazosin (- AZOSIN ending)
21. Antidote used for heparin overdose
Dimercaprol
Phenytoin
Protamine
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
22. System that increases in activity with chronic ethanol exposure and may contribute to tolerance
Radioactive iodine
Alprostadil
EOS
Cevimeline
23. SE of clonidine
Rebound HTN - sedation - dry mouth
Acetazolamide
Chlordiazepoxide and Diazepam
Apraclonidine - brimonidine
24. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
Metrifonate
Haloperidol
Amphetamines
Bromocriptine
25. A1a - selective blocker with no effects on HTN used for BPH
Beta - blockers such as propranolol
Fluoxetine
Most are thought to act at GABA- A receptor - chloride channel
Tamsulosin (Flomax)
26. Anti - androgen used for prostate cancer
Flutamide (Eulexin)
LFT's
Loading dose (Cp*(Vd/F))
Cyanocobalamin (Vit B12)
27. Opioid that can be given PO - by epidural - and IV - which helps to relieve the dyspnea of pulmonary edema
L- asparaginase
Abstinence syndrome
Gastric ulcers and GI Bleeding
Morphine
28. Drug ofter used in combination with TNF - alpha inhitors for RA
ORAL vancomycin
Methotrexate
Salmeterol
Phenytoin
29. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
Ketoralac
Sodium channel blockers
Dimercaprol - EDTA
Severe hypertension
30. Hormone inhibiting prolactin release
Dopamine
Leuprolide
Raloxifene (SERM- selective estrogen receptor modulator)
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
31. Nonselective alpha - blocking drug - long acting and irreversible - and used to treat pheochromocytoma. Blocks 5- HT - so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis
Diazepam
Phenoxybenzamine
Methotrexate
Amiodarone
32. Clinical response that may fluctuate in tx of Parkinson's dx
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33. Drug of choice for leprosy
Buspirone
Desflurane
Dapsone - rifampin and clofazimine combination
Serotonin syndrome
34. Carbonic anhydrase inhibitor
Low - potency typical antipsychotics and clozapine
Acetazolamide
Cyclophosphamide
Sotalol
35. TCA used in obsessive compulsive disorder (OCD) - most significant of TCA's for risk of seizure - weight gain - and neuropsychiatric signs and symptoms
Epinephrine
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Naloxone
Clomipramine
36. Receptors for serotonin (5HT-1) are located
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Heparin induced thrombocytopenia (HIT)
Labetalol and carvedilol
Norepinephrine and serotonin
37. MOA of class I A (eg. Procainamide) - class IB (eg. Lidocaine) - and class IC (eg. Flecainide) antiarrhythmics
Carbamazepine
Sodium channel blockers
Ceftriaxone or cefuroxime
Thiopental
38. Important in muscle and adipose tissue for glucose transport across muscles and TG storage by lipoprotein lipase activation
GLUT 4
Minoxidil
Albuterol
Rescue therapy
39. H1 antagonist used in motion sickness
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Entacapone and Tolcapone
Nitrous oxide
Dimenhydrinate - meclizine - and other 1st generation
40. Limiting side effect of Quinidine
Disulfiram - like reaction
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Prolongs QT interval
L- asparaginase
41. Common side effect of Rifampin
Red urine discoloration
Ferrous sulfate
Thiopental
Neutropenia and agranulocytosis
42. These agents decrease blood flow or increase blood pressure - are local decongestants - and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion
Alpha1 agonists
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Arginine
Dantrolene
43. These LA's have surface activity
Pralidoxime
Hydroxychloroquine
Benztropine
Cocaine and benzocaine
44. Cutaneous flush and be reduced by pretreatment with
Bile acid - binding resins
Normal C- peptide
Desmopressin (DDAVP)
Aspirin
45. Most commonly abused in health care professionals
Potassium channel blockers
Affect calcium - potassium - and sodium channels
Heroin - morphine - oxycodone - meperidine and fentanyl
Gingival hyperplasia
46. For rebound HTN from rapid clonidine withdrawal
Constipation - edema - and headache
Kidney and liver toxicity - diarrhea
L- asparaginase
Phentolamine
47. Local anesthetic with vasoconstrictive property - favored for head - neck - and pharyngeal surgery
Cocaine
Infliximab
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Dipyridamole
48. Somatotropin (GH) analog used in GH deficiency (dwarfism)
Glyburide - glipizide - and rosiglitazone
Fluoxetine
Somatrem
Normal C- peptide
49. SSRI less likely to cause a withdrawal syndrome
Nitrites
Fluoxetine
Calcium channel blockers
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
50. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Inhibits osteoclast bone resorption
Pre - existing cardiac or renal disease
Valproic acid
Dantrolene