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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Beta blockers are used for which type of anginal attack
Cyclophosphamide
Venlafaxine
Classic
Loading dose (Cp*(Vd/F))
2. Class III antiarrhythmic that exhibits properties of all 4 classes
Ketoconazole
Potassium channel blockers
Bupropion
Amiodarone
3. Drug notorious for causing pseudomembranous colitis
Ceftriaxone or cefuroxime
Clindamycin
Celecoxib and rofecoxib
SSRIs
4. DOC for paroxysmal supraventricular tachycardia; has high efficacy and short duration of action
Sedation
Dicyclomine - methscopolamine
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Adenosine
5. Interact with microtubules (but unlike vinca which prevent disassembly of tubules) - it stabilizes tubulin and cells remain frozen in metaphase
L- thyroxine (T4)
Normal C- peptide
Hyperkalemia
Paclitaxel (taxol)
6. SE of tPA
Pyridostigmine
Cerebral hemorrhage
Muscarinic blockers
Bone marrow and teeth discoloration for children under 8 years of age
7. Diuretics work in CHF by
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Reducing preload
inhibits Na+/K+/2Cl - cotransport
Beta - blockers such as propranolol
8. Cephalosporin causes kernicterus in neonates
Epinephrine
Ceftriaxone or cefuroxime
Ethanol
Oral
9. Some cell cycle non - specific drugs
Norepinephrine and serotonin
Prinzmetal's angina
Repaglinide
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
10. Thrombolytics are used for
Abstinence syndrome
Pulmonary embolism and DVT
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
11. First generation sulfonylurea
Methimazole and propylthiouracil (PTU)
Etidronate
Chlorpropamide - tolbutamide - tolazamide - etc.
Ethanol
12. New class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins
Radioactive iodine
Dextromethorphan - Codeine
Dexamethasone suppression test
Ezetimibe (Zetia)
13. Non - benzodiazepine used as an anxiolytic
Cutaneous flush
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Buspirone
block SLUD (salivation - lacrimation - urination - defecation
14. Regimen used for breast cancer
Sodium channel blockade
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Chlorpropamide - tolbutamide - tolazamide - etc.
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
15. Prevention of cyclophosphamide induced hemorrhagic cystitis
Pamidronate - zoledronate - ibandronate
Hydration and mercaptoethanesulfonate (MESNA)
Bile acid - binding resins
Sulfonamides
16. Concern using lithium
Low therapeutic index
Testicular cancer
NSAIDS
Fomepizole
17. Anti - seizure agent that exhibits non - linear metabolism - highly protein bound - causes fetal hydantoin syndrome - and stimulates hepatic metabolism
Acetazolamide
Phenytoin
Competitive antagonist
Protamine
18. Antidote used for benzodiazepine toxicity
Flumazenil
Overdose of opioids
Minimum alveolar anesthetic concentration (MAC)
Lupus - like syndrome
19. Drug used for MRSA
Vancomycin
Islets of Langerhans
Zileuton
Inhibits osteoclast bone resorption
20. Antidote for hyperkalemia
Liver toxicity - increased serum cholesterol
sodium polystyrene sulfonate (Kayexalate)
Bile acid - binding resins
Valproic acid
21. Fluoride released by metabolism of this inhaled anesthetic may cause renal insufficiency
Indomethacin
Cartilage damage
Methoxyflurane
Work at early distal convoluted tubule
22. SE of Amiodarone
DOM - STP - MDA - and MDMA 'ecstasy'
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Postsynaptic Mu receptors
Finasteride (Proscar and Propecia respectively)
23. Non - benzodiazepine used for sleep
Zolpidem
Nesiritide (Natrecor)
Amoxapine
AZT (zidovudine)
24. Selective Alpha 2 blocker used for impotence (controversial effectiveness)
Caffeine
Atracurium
Barbiturates - phenytoin - carbamazepine - and rifampin
Yohimbine
25. This beta blocker is highly lipid soluble and may account for side effects such as nightmares
Propranolol
Ketoralac
Acarbose - miglitol
Diazepam
26. Drug elimination with a constant amount metabolized regardless of drug concentration
Penicillamine
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Zero order kinetics
Prinzmetal's angina
27. Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)
Digibind
Therapeutic index
Rescue therapy
Combination oral contraceptives (OC)
28. Opioids used in anesthesia
Entacapone and Tolcapone
Metronidazole
Morphine and fentanyl
Folic acid
29. Antidote used for digitalis toxicity
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Aminocaproic acid
Salmeterol
Hypoglycemia
30. Amphetamine agents
Dimenhydrinate - meclizine - and other 1st generation
Classic
Celecoxib and rofecoxib
Dextroamphetamines and methamphetamine
31. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Vancomycin
Infliximab
sulfamethoxazole/ trimethoprim
Acetazolamide
32. Side effects frequently seen with SSRIs
Bleeding
CNS stimulation; GI upset
Autocoids
Naloxone (IV) - naltrexone (PO)
33. Causes bone marrow suppression
block SLUD (salivation - lacrimation - urination - defecation
Methotrexate
Chemical esophagitis
Na+/K+ exchange
34. MAOI should not be administered with SSRI's or potent TCA's due to development of this condition
Retinal destruction and dermatitis
Fluoxetine
Serotonin syndrome
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
35. Agent used for acute muscle spasm
Fludrocortisone and deoxycorticosterone
Nitrous oxide
Cyclobenzaprine
Clomipramine
36. Irreversible condition resulting from the use of antipsychotics - reserpine at high doses - and MPTP (by- product of illicit meperidine analog)
Drug induced Parkinsonism
Aminocaproic acid
Ketamine
Aspirin irreversibly inhibits cyclooxygenase
37. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Valproic acid - carbamazepine - phenytoin and gabapentin
Beta - blockers
sodium polystyrene sulfonate (Kayexalate)
38. SE for Lamotrigine
Stevens - Johnson syndrome
Nitroprusside
Paclitaxel (taxol)
Adenosine
39. 3 zones of adrenal cortex and their products
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Delavirdine - efavirenz - and ribavirin
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Carbidopa
40. Muscarinic antagonist used in asthma
Ipratropium
Aplastic anemia and acute hepatic failure
Aldehyde dehydrogenase
Nevirapine - amprenavir
41. MOA action of cromolyn
Reduce the loss from area of injection
Clearance (CL)
Demeclocycline
Mast cell stabilizer
42. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Stimulates cGMP which leads to vascular smooth muscle relaxation
Nefazodone
Halothane and methoxyflurane
Phentolamine
43. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Dantrolene
Nifurtimox
L- asparaginase
Timolol
44. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism
Iodide salts
Bromocriptine
Cutaneous flush
Ipratropium
45. Non - steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Antipyretic and analgesic activity
Diethylstilbestrol (DES)
Neutro - leuko and thrombocytopenia
46. DOC for malignant hyperthermia by acting on the sacroplasmic reticulum or skeletal muscle
Heroin - morphine - oxycodone - meperidine and fentanyl
LFT's
Dantrolene
Inhibit DNA gyrase
47. Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)
Echothiophate
Bromocriptine
Bradykinin and histamine
Muscarinic blockers
48. Antipsychotic having the strongest autonomic effects
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Pulmonary embolism and DVT
Thioridazine
inhibit phospholipase A2
49. Antivirals associated with neutropenia
Vancomycin - infusion at a slow rate and antihistamines
Ganciclovir - zidovudine - saquinavir - and interferon
B- blockers
Inhibit dihydropteroate synthase
50. Usual time needed for full effect of antidepressant therapy
Prednisone - methylprednisolone - prednisolone - and triamcinolone
2 to 3 weeks
Phenoxybenzamine
Hypokalemia