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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Type of kinetics when a constant percentage of substrate is metabolized per unit time






2. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents






3. Antiestrogen drugs used for fertility and breast cancer respectively






4. Causes bone marrow suppression






5. Usual time needed for full effect of antidepressant therapy






6. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension






7. Alpha - glucosidase inhibitor associated with elevation of LFT's






8. Toxicity of these agents include bradycardia - AV blockade - exacerbation of acute CHF; signs of hypoglycemia may be masked (tachycardia - tremor - and anxiety)






9. Opioid antagonist that is given orally in alcohol dependency programs






10. For rebound HTN from rapid clonidine withdrawal






11. Most important potential SE of metformin






12. Antihistamine that can be used for anxiety and insomnia and is not addictive






13. Structurally related to acetylcholine - used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation






14. Presynaptic Alpha 2 agonist used in HTN - and acts centrally






15. Agent used for anemias associated with renal failure






16. CCB are DOC for

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17. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma






18. Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because






19. Endogenous insulin contains






20. Indirect - Acting ACh Agonist - alcohol - short DOA and used in diagnosis of myasthenia gravis






21. Constant proportion of cell population killed rather than a constant number






22. Anti - psychotics available in depot preparation






23. Tolerance to all effects of opioid agonists can develop except






24. Prevents thrombosis in patients with artificial heart valve






25. SE of procainamide






26. Non - benzodiazepine used as an anxiolytic






27. SE of beta blockers






28. SSRI indicated for premenstrual dysphoric disorder






29. Antidote for thrombolytics






30. Treatments available for nicotine addiction






31. Peakless ling acting insulin






32. Removal of PCP may be aided






33. Antivirals that are teratogens






34. Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine - like side effects






35. Inducers of Cytochrome P450 (CYP450)






36. Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso - enzyme.






37. Facilitates GABA presynaptic inhibition






38. Antidote used for organophosphate/anticholinesterase poisoning






39. Class of drugs with ability to decrease the maximal response to an agonist






40. Enhances dopaminergic neurotransmission SE's include CNS excitation - acute toxic psychosis and livedo reticularis






41. Drug used in ergot alkaloids overdose - ischemia and gangrene






42. Except for these agents all SSRI have significant inhibition of CytP450 enzymes






43. Opioid antagonist that is given IV and had short DOA






44. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction






45. SE of demeclocycline






46. The fraction of administered dose of a drug that reaches systemic circulation






47. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease






48. GABA agonist in the spinal cord






49. Short acting glucocorticoids






50. Diuretic used to antagonize aldosterone receptors