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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antidote used for iron salt toxicity
Deferoxamine
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Potency
Benztropine - trihexyphenidyl
2. THC is active ingredient - SE's include impairment of judgment - and reflexes - decreases in blood pressure and psychomotor performance occur
Iodide salts
Marijuana
Thrombocytopenia
Fexofenadine - loratadine - and cetirizine
3. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Vincristine
Sumatriptan - naratriptan - and rizatriptan
Dobutamine
Clonazepam
4. Anti - progesterone used as abortifacient
Mifepristone (RU-486)
Volume of distribution (VD)
Benztropine - trihexyphenidyl
Esmolol
5. SE of hydroxychloroquine
Vancomycin
Methotrexate
Carbamazepine
Retinal destruction and dermatitis
6. SSRI indicated for premenstrual dysphoric disorder
Fluoxetine (Sarafem)
Gabapentin
Olanzapine
Reduce inhibition - suppress anxiety - and produce relaxation
7. Carbamazepine may cause
Olanzapine - aripiprazole - and sertindole
Hydroxychloroquine
Lithium
Agranulocytosis
8. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Megaloblastic anemia
Valproic acid
Prinzmetal's angina
Acetazolamide
9. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Aminoglutethimide
Cyanide toxicity treated with sodium thiosulfate
Fentanyl
10. Toxicities include nephrotoxicity and ototoxicity - leading to a severe interaction with aminoglycosides
Cisplatin
Bile acid - binding resins
Specificity
Autocoids
11. Opioid used in the management of withdrawal states
Nortriptyline - Desipramine
Malathion
Methadone
Pindolol and acebutolol
12. Anti - microbials that cause hemolysis in G6PD- deficient patients
Abstinence syndrome
Sulfonamides
Insulin
Elderly patients
13. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Ethanol
Neostigmine
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Zileuton
14. Antiarrhythmic that exhibits Class II and III properties
Pentoxifylline
Amiodarone
Magnesium sulfate
Sotalol
15. Drugs of choice for status epilepticus
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
'On - off - phenomenon'
Echothiophate
Flumazenil
16. These agents are congeners of Amphetamine
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17. Metronidazole SE if given with alcohol
Ribavirin
Cholinesterase inhibitors
Disulfiram - like reaction
Ascending pathways
18. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Metronidazole
Nondepolarizing type antagonists
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Glucocorticoids
19. Nitrate free intervals are needed due to
Tolerance
G- CSF (filgrastim) and GM- CSF (sargramostim)
Marijuana
Bromocriptine
20. Antihistamine that can be used for anxiety and insomnia and is not addictive
hydroxyzine (Atarax)
Doxepin
Ascending pathways
Maprotiline
21. The most common neurologic abnormality in chronic alcoholics
GABA- related targets
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Aspirin - metoprolol
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
22. MOA of neuroleptics
Dopamine blockade
SSRI's - bupropion - and venlafaxine
Sulfonamides
Glucuronate - acetic acid - and glutathione sulfate
23. Approved for use in severe pulmonary HTN
None
PGI2 (epoprostenol)
Oral
Hyperkalemia
24. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors
Octreotide
Pulmonary embolism and DVT
Glucuronate - acetic acid - and glutathione sulfate
Increasing sodium excretion and decreases arterial and venous tone
25. Type of kinetics when a constant percentage of substrate is metabolized per unit time
Inhibit dihydropteroate synthase
Propranolol
First order kinetics
Dimercaprol - EDTA
26. Effective in preventing TIA's
Clopidogrel and ticlopidine
Oral and transdermal forms of nitroglycerin
Benztropine - trihexyphenidyl
Adalimumab - infliximab and etanercept
27. SE of clonidine
NO - chloroform - and diethyl ether
Magnesium sulfate
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Rebound HTN - sedation - dry mouth
28. Some side effects of corticosteroids
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Acute intermittent porphyria
Zileuton
Scotch tape technique and mebendazole
29. Pyrimidine analog that causes 'Thymine - less death' given with leucovorin rescue
Acebutolol - atenolol - esmolol - metoprolol
Ketamine
5- flouracil (5- FU)
Thiopental
30. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Efficacy
Nifedipine
Bupropion
Cosyntropin
31. Antiarrhythmic effective in most types of arrhythmia
Clomiphene and tamoxifen
Amiodarone
Sodium channel blockade
Succinylcholine
32. Selective alpha agonists that decreases aqueous secretion
Liver enzyme INDUCTION
Apraclonidine - brimonidine
Infants - closed angle glaucoma - prostatic hypertrophy
Neutro - leuko and thrombocytopenia
33. MOA of repaglinide
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Atracurium
Disulfiram - like reaction
Spironolactone
34. This step of metabolism makes a drug more hydrophilic and hence augments elimination
Carbamazepine
Phase I
Amoxicillin
Gingival hyperplasia
35. Agents used in Huntington's Disease
Aztreonam
Fludrocortisone and deoxycorticosterone
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Fomepizole
36. Loops lose and thiazide diuretics retain
Thrombocytopenic purpura - and CINCHONISM
Calcium
Irreversibly blocking cyclooxygenase
Tizanidine
37. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation
Dexrazoxane
Valproic acid
Specificity
Olanzapine - aripiprazole - and sertindole
38. Anti - psychotic not shown to cause tardive dyskinesia
Monamine oxidase inhibitors
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Clozapine
Severe hypertension
39. COX 2 inhibitors should be used cautiously in pts with
Pre - existing cardiac or renal disease
Dimercaprol
Tetracaine and bupivacaine
Ethanol
40. Drug of choice for leprosy
Administration of Vit. B6 (pyridoxine)
Verapamil
Dapsone - rifampin and clofazimine combination
Pyridostigmine
41. Benzodiazepines that are the most effective in the treatment of panic disorder
Alprazolam and Clonazepam
Atropine - pralidoxime (2- PAM)
Testosterone
Methicillin - nafcillin - and dicloxacillin
42. Reason troglitazone was withdrawn from market
Sulfonamides
Methotrexate
Hepatic toxicity
Neuromuscular blocking drugs
43. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
Phase I
Levodopa
Monamine oxidase inhibitors
Timolol (nonselective) - betaxolol (selective)
44. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Thioridazine
Atenolol - acebutolol - and metoprolol
Propoxyphene
Raloxifene
45. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
Tamsulosin
Caffeine
Volume of distribution (VD)
PGE1
46. SE of colchicine
Protamine sulfate
Neutropenia and agranulocytosis
Hydralazine
Kidney and liver toxicity - diarrhea
47. MOA of thiazolindinediones
Sinus tachycardia and serious arrhythmias
DOM - STP - MDA - and MDMA 'ecstasy'
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
'On - off - phenomenon'
48. MOA of cisplatin
Alkylating agent
Retinal destruction and dermatitis
Thioridazine
Propranolol
49. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Risperidone
Epinephrine
Amitriptyline
Efficacy
50. Interaction with this drug requires dose reduction of 6- MP
Mannitol
Therapeutic index
Allopurinol
Scopolamine - meclizine