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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Clinical response that may fluctuate in tx of Parkinson's dx
2. Increase bone density - also being tested for breast CA prophylaxis
First pass effect
Tamsulosin
Raloxifene (SERM- selective estrogen receptor modulator)
Kidneys
3. Benzodiazepines used to promote sleep
Fluorocarbons and Industrial solvents
Temazpam - trizolam - flurazepam
Octreotide
Glucagon
4. Antidote for hyperkalemia
Bromocriptine
Acyclovir; incorporated into viral DNA and chain termination
Phenytoin
sodium polystyrene sulfonate (Kayexalate)
5. Agent that inhibits alcohol dyhydrogenase and its clinical use
Flumazenil
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Cyclophosphamide
6. SE of penicillamine
ACE inhibitors
CNS toxicity
Aplastic anemia and renal toxicity
Rebound HTN - sedation - dry mouth
7. Used intravenously for acute arrhythmias during surgery
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
Esmolol
Gingival hyperplasia - nystagmus - diplopia and ataxia
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
8. Agent that is a partial agonist for the 5- HT1A receptor
Buspirone
Baclofen
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Increase the DURATION of GABA- mediated chloride ion channels
9. Class of antibiotics that have 10% cross sensitivity with penicillins
Leucovorin
Rebound HTN - sedation - dry mouth
Sinus tachycardia and serious arrhythmias
Cephalosporins
10. Newer NSAID that selectively inhibits COX-2
N- acetylcysteine (Mucomyst)
Celecoxib
Meperidine
Most are thought to act at GABA- A receptor - chloride channel
11. Anti - androgen used for hirsutism in females
Celecoxib
Cyproterone acetate
Enflurane and halothane
Aspirin
12. Similar to clonidine and may cause hypotension
Cocaine 'super - speed'
Tizanidine
Vitamin B12
Older antipsychotic agents - D2 receptors
13. Anti - rheumatic agent also used for Chron's disease
Epinephrine
Methadone - followed by slow dose reduction
Aldehyde dehydrogenase
Infliximab
14. MOA of tetracycline
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Decreases protein synthesis by inhibiting 30S ribosome
Dextromethorphan - Codeine
Protamine
15. Beta 1 agonists used in acute CHF
Atracurium
Dobutamine and dopamine
Desflurane
Valproic acid
16. Antidote used for warfarin toxicity
Hepatic
Vitamin K and Fresh frozen plasma (FFP)
Class IC (flecainide - propafenone - moricizine)
Minimum alveolar anesthetic concentration (MAC)
17. Antifungal agent used for inhibition of all gonadal and adrenal steroids
Cosyntropin
Ethanol - fomepizole
Tetracaine and bupivacaine
Ketoconazole
18. Drug used for N. gonorrhea in females
Esmolol
Gynecomastia hyperkalemia - and impotence
Ceftriaxone
Clonazepam
19. Antidote for beta - blockers and hypoglycemia
Epinephrine - dipivefrin
Glucagon
Protease inhibitors
Folic acid
20. SE of demeclocycline
Bone marrow and teeth discoloration for children under 8 years of age
Nephro and ototoxicity
Venlafaxine
Nesiritide (BNP)
21. SSRI less likely to cause a withdrawal syndrome
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Clomiphene and tamoxifen
Prilocaine
Fluoxetine
22. Drug used in cancer therapy causes Cushing - like symptoms
EOS
Prednisone
Flumazenil
Depression of medullary and cardiovascular centers
23. SE of acetazolamide
Fluoxetine (Sarafem)
Patches - gum - nasal spray - psychotherapy - and bupropion
Flumazenil
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
24. Another pneumonic for anticholinergic toxicity
25. Peptide drug used to treat CHF
Nesiritide (BNP)
Mivacurium
Morphine and fentanyl
Hypertensive crisis
26. Methylxanthine derivative used as a remedy for intermittent claudication
Pentoxifylline
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
hydroxyzine (Atarax)
Competitive antagonist
27. Toxicity of anticholinergics
block SLUD (salivation - lacrimation - urination - defecation
Salmeterol
Codeine - hydrocodone - and oxycodone
Morphine and fentanyl
28. These beta blockers are less lipid soluble
Digibind
Pyridostigmine
Pregnancy
Acebutolol and atenolol
29. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction
Physostigmine
Fludrocortisone and deoxycorticosterone
Meperidine
Epinephrine - dipivefrin
30. What do beta cells in the pancreas produce?
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
2 to 3 weeks
Half - life (T1/2)
Insulin
31. B- blockers that are more cardioselective
Thiopental
Hydroxychloroquine
Beta -1 selective blockers
Buprenorphine
32. Alpha - glucosidase inhibitor associated with elevation of LFT's
Acarbose
Reducing preload
Streptokinase
Dantrolene
33. Class of drugs with ability to decrease the maximal response to an agonist
Glyburide - glipizide - glimepiride - etc.
Primaquine
Noncompetitive antagonist
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
34. Side effects frequently seen with SSRIs
Octreotide
Miosis and constipation
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
CNS stimulation; GI upset
35. Antidote used for organophosphate/anticholinesterase poisoning
Atracurium
Nitrous oxide
Mifepristone (RU-486)
Atropine - pralidoxime (2- PAM)
36. Aminoglycosides used with loop diuretics potentiate adverse effect
Ipratropium
Ototoxicity
Phenylephrine
Hydroxychloroquine
37. Side effects seen with tricyclic antidepressants
Deferoxamine
Sulfonamides
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Bupropion
38. Anti - rheumatic agent also used for ulcerative colitis
Sulfasalazine
Esmolol
Methotrexate
Aspirin
39. Drugs of choice for generalized tonic - clonic and partial seizures
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Spasmolytic drugs
Valproic acid and Phenytoin
Lactic acidosis
40. Short acting glucocorticoids
Stimulates cGMP which leads to vascular smooth muscle relaxation
Prolongs QT interval
2 to 3 weeks
Cortisone and hydrocortisone (equivalent to cortisol)
41. Antidepressant with MOA as alpha 2 antagonist - has effects on both 5- HT and NE - blocks histamine receptors - and is sedating
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Nicotine
Penicillamine
Mirtazapine
42. Atropine fever is the most dangerous effect and can be lethal in this population group
GFR
Infants
Sulfasalazine
Terbutaline
43. Inhibitors of CYP450
Ketanserin cyproheptadine - and phenoxybenzamine
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Nefazodone
44. Nonselective alpha - blocking drug - short acting and reversible - used for rebound HTN from rapid clonidine withdrawal - and Raynaud's phenomena
Probenecid and sulfinpyrazone
Salmeterol
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Phentolamine
45. Life threatening cardiac event that prolong QT leads to
Sumatriptan
Torsades de pointes
Noncompetitive antagonist
ORAL vancomycin
46. 1st generation antihistamine that is highly sedating
Diphendydramine
Rescue therapy
Neutropenia and agranulocytosis
Reducing progression of heart failure (never use in acute heart failure)
47. SSRI with long T1/2 and can be administered once weekly for maintenance - not acute tx
Fluoxetine
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Phentolamine
Fentanyl
48. Peakless ling acting insulin
Allopurinol
Insulin glargine
Nifedipine
Nondepolarizing Neuromuscular Blockers
49. Routes of administration of heparin
Glucagon
IV and IM (only LMW)
Nondepolarizing type antagonists
Morphine and fentanyl
50. MOA of neuroleptics
Ceftriaxone
Salmeterol
Dopamine blockade
Meperidine