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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Used in pediatrics to maintain patency of ductus arteriosis
PGE1
Celecoxib
Phenytoin
Aminoglutethimide
2. Agents used in Huntington's Disease
Dextromethorphan - Codeine
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
3. Pneumonic for 3 zones of adrenal cortex
High therapeutic index
Full agonist
Specificity
GFR
4. Drugs available in combination with metformin
Glyburide - glipizide - and rosiglitazone
Calcium
Antipyretic and analgesic activity
Low - potency typical antipsychotics and clozapine
5. Type of resistance found with vancomycin
Serotonin syndrome
Enflurane and halothane
Point mutation
Liver toxicity
6. Selectivity of a drug for its receptor
Specificity
Midodrine
Acarbose - miglitol
Minimum alveolar anesthetic concentration (MAC)
7. Where are beta cells found in the pancreas?
Islets of Langerhans
Propranolol
Amiodarone
Lupus - like syndrome
8. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation
Rheumatic disease
NSAIDS
Fluorocarbons and Industrial solvents
Thyroid and steroid hormones
9. Osmotic diuretic used to treat increased intracranial pressure
Mannitol
Nitrous oxide
Estrogen (HRT- Hormone replacement therapy)
Prolongs QT interval
10. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Interleukin 11 (oprelvekin)
Atracurium
Minocycline
Urinary acidification and activated charcoal or continual nasogastric suction
11. Ergot alkaloid used as an illicit drug
SEVERE myelosuppression
LSD
Ganciclovir
Cocaine 'super - speed'
12. Beta 1 agonists used in acute CHF
Maprotiline
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Dobutamine and dopamine
Rheumatic disease
13. Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs
Chlordiazepoxide and Diazepam
Clindamycin
Little C- peptide
Amoxapine
14. NSAID used in gout
Heparin
Clonazepam
Indomethacin
Prednisone - methylprednisolone - prednisolone - and triamcinolone
15. Common SE of spironolactone
Gynecomastia and hyperkalemia
Buspirone
Hydroxychloroquine
Gingival hyperplasia
16. Agent effective in physiologic and essential tremor
Atropine - homatropine - C1208 tropicamide
Abciximab - tirofiban and eptifibatide
Baclofen
Propranolol
17. Names of three bisphosphonates available IV
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Pamidronate - zoledronate - ibandronate
Gynecomastia and hyperkalemia
TD50
18. DOC for RSV
Theophylline
Ribavirin
Stevens - Johnson syndrome
Sedation
19. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Phenoxybenzamine
Ketamine
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Midodrine
20. Increased risk of developing cataracts
Clozapine
Allopurinol
Quetiapine
Mivacurium
21. Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
Temazpam - trizolam - flurazepam
IV and IM (only LMW)
Estrogen
Diazepam
22. Ultra long acting insulin - has over a day duration of action
Estrogen
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Glargine (Lantus) - detemir
Bethanechol
23. Analog of hypoxanthine - needs HGPRTase for activation
6- mercaptopurine (6- MP)
Ketoconazole
block SLUD (salivation - lacrimation - urination - defecation
Severe hypertension
24. Leads to respiratory depression progressing to coma and death
Morphine and fentanyl
Overdose of opioids
Calcitonin (salmon prep)
Lipoprotein lipase
25. Antiarrhythmic that exhibits Class II and III properties
Sotalol
Atracurium
Tissue plasmin activator
Aldehyde dehydrogenase
26. Receptors for serotonin (5HT-1) are located
Cephalosporins
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Capsaicin
Terbutaline
27. Newer alpha 2 agonist (apraclonidine and brimonidine) treat glaucoma by acting to
Reduce aqueous secretion
GFR
Cerebral hemorrhage
Infants - closed angle glaucoma - prostatic hypertrophy
28. Fibrates are contraindicated in
Ability to cross the placenta
Affect calcium - potassium - and sodium channels
Ototoxicity
Pregnancy
29. Type of kinetics when a constant percentage of substrate is metabolized per unit time
Streptomycin
Miosis and constipation
First order kinetics
Acyclovir; incorporated into viral DNA and chain termination
30. Almost all local anesthetics have this property and sometimes require the administration of vasoconstrictors (ex. Epinephrine) to prolong activity
Valproic acid and Phenytoin
Vasodilation
Protamine
Nitrous oxide
31. Organophosphate anthelmintic agent with long DOA
Anterograde amnesia
Stevens - Johnson syndrome
Metrifonate
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
32. Common side effect of hypnotic agents
Presynaptic mu - delta - and kappa receptors
Pyridostigmine
Fentanyl
Sedation
33. Prostaglandins that cause abortions
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Neostigmine
Acetazolamide
34. MOA of penicillin
Niacin
Potassium channel blockers
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Tamoxifen
35. Carbonic anhydrase inhibitor
Aspirin
Acetazolamide
Sedation
Cartilage damage
36. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease
Spasmolytic drugs
Sumatriptan
Prolonged half - life - up to six weeks
Administration of Vit. B6 (pyridoxine)
37. Loops lose and thiazide diuretics retain
Nausea
Octreotide
Little C- peptide
Calcium
38. Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Gynecomastia and hyperkalemia
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Etidronate
39. MOA of local anesthetics (LA's)
Block voltage - dependent sodium channels
Alpha1 agonists
Dobutamine
SSRI's - bupropion - and venlafaxine
40. Limiting side effect of Quinidine
Dexrazoxane
Prilocaine
Prolongs QT interval
Miosis and constipation
41. Antidepressant associated with neuroleptic malignant syndrome
Insulin
Insulin secretagogue - closes ATP- sensitive K+ channel
Nateglinide
Amoxapine
42. MOA of thiazolindinediones
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
Testicular cancer
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Odansetron
43. Reason troglitazone was withdrawn from market
Potassium channel blockers
Ketoconazole
Hepatic toxicity
Buprenorphine
44. This parenteral beta blocker is a short acting (minutes)
Midazolam
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Nevirapine - amprenavir
Esmolol
45. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Beta1 agonists
Inhibits osteoclast bone resorption
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
Ferrous sulfate
46. Used intravenously for acute arrhythmias during surgery
Esmolol
Indomethacin
Point mutation
Baclofen
47. Nitrate free intervals are needed due to
Reducing preload
Hepatotoxicity
Tolerance
Metronidazole
48. SE of nesiritide
Excessive hypotension and kidney failure
Hyperuricemia - hypokalemia and hyperglycemia
Cosyntropin
Tizanidine
49. Lithium is associated with this congenital defect
Cardiac anomalies and is contraindicated in pregnancy or lactation
Esmolol
Iron deiodinates thyroxine
Low therapeutic index
50. GABA agonist in the spinal cord
Allopurinol
Tamsulosin (Flomax)
sulfamethoxazole/ trimethoprim
Baclofen