SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Opioid used in the management of withdrawal states
Rheumatic disease
Maprotiline
Terfenadine and astemizole (have been removed from the market)
Methadone
2. Antidote to reverse actions of warfarin
Fluphenazine and haloperidol
Vitamin K or fresh frozen plasma
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Ethanol
3. Four main actions of NSAIDS
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Clomiphene and tamoxifen
ACE inhibitors
Tamoxifen
4. Aspirin reduces mortality in unstable angina by
Fludrocortisone and deoxycorticosterone
Platelet aggregation inhibition
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Vancomycin - infusion at a slow rate and antihistamines
5. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients
Therapeutic index
Prolongs QT interval
Sedation
Beta blockers
6. Anti - androgen used for prostate cancer
Sedation
Ketanserin cyproheptadine - and phenoxybenzamine
Flutamide (Eulexin)
Bleeding
7. Non - selective Beta - blocker also used for migraine prophylaxis
Propranolol
Clearance (CL)
CNS toxicity
Leuprolide
8. Ability to bind reversibly to the same site as the drug and without activating the effector system
Phenobarbital
Pramipexole and ropinirole
Competitive antagonist
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
9. Methyldopa is contraindicated in
Geriatrics due to its CNS (depression) effects
Cutaneous flush
Most are thought to act at GABA- A receptor - chloride channel
Cocaine and benzocaine
10. ACE inhibitors are contraindicated in
pregnancy and with K+
Acebutolol and atenolol
SSRI's - bupropion - and venlafaxine
Fluphenazine and haloperidol
11. SE of Amiodarone
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Bromocriptine
Amantadine
Hypertrichosis
12. Nitrate free intervals are needed due to
Clonazepam
Tolerance
Cutaneous flush
Low - potency typical antipsychotics and clozapine
13. Relates the amount of drug in the body to the plasma concentration
Volume of distribution (VD)
NO - chloroform - and diethyl ether
'On - off - phenomenon'
Estogens increase maternal TBG
14. Class of antibiotics that have 10% cross sensitivity with penicillins
Terbutaline
Sodium channel blockade
Dextromethorphan - Codeine
Cephalosporins
15. Vitamin K dependent anticoagulant
Metronidazole
Sodium channel blockers
Warfarin (PT)
DOM - STP - MDA - and MDMA 'ecstasy'
16. Similar to clonidine and may cause hypotension
Cyclophosphamide
Tizanidine
Side - effect profile and prior pt response
Phase I
17. Prototypical drug is atropine
Ketanserin cyproheptadine - and phenoxybenzamine
Oral and transdermal forms of nitroglycerin
Nonselective Muscarinic Antagonists
Pregnancy
18. DOC for status epilepticus
Indomethacin
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Diazepam
Decreased micro and macro vascular disease
19. Agent used in the treatment of alcoholism - if alcohol is consumed concurrently - acetaldehyde builds up and results in nausea - headache - flushing - and hypotension
Sodium channel blockade
Vancomycin - infusion at a slow rate and antihistamines
Phenoxybenzamine
Disulfiram
20. Readily detected markers that may assist in diagnosis of the cause of a drug overdose include
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
high doses
Constipation - edema - and headache
Phenytoin
21. Alternative anticoagulant used if HIT develops
Sumatriptan - naratriptan - and rizatriptan
Retinal destruction and dermatitis
Lepirudin
Ganciclovir
22. SE of methyldopa
23. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Ezetimibe (Zetia)
Ethanol
DOM - STP - MDA - and MDMA 'ecstasy'
Decreases protein synthesis by inhibiting 30S ribosome
24. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)
high doses
Entacapone and Tolcapone
Glyburide - glipizide - and rosiglitazone
Flutamide (Eulexin)
25. Some of SSRIs' therapeutic effects beside depression
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Alprostadil
Inhibit Cytochrome P450 3A4
Sedation
26. The elimination of drug that occurs before it reaches the systemic circulation
First pass effect
Somatrem
Dry cough - hyperkalemia
Glucagon
27. Antidote for thrombolytics
Hypoglycemia
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Kidney and liver toxicity - diarrhea
Aminocaproic acid
28. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Halothane and methoxyflurane
Nesiritide (BNP)
Tertiary amines
hydroxyzine (Atarax)
29. Three C's associated with TCA toxicity
Cocaine
Tricyclic antidepressants (TCA)
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Calcium
30. Example of three antidepressants that are indicated for obsessive compulsive disorder
hydroxyzine (Atarax)
Clomipramine - fluoxetine and fluvoxamine
Red urine discoloration
Infliximab
31. Antidote for acetaminophen toxicity
Nandrolone - oxymetholone - and oxandrolone
Dopamine
Sulfasalazine
N- acetylcysteine
32. Approved for use in severe pulmonary HTN
PGI2 (epoprostenol)
Hypertensive crisis
Bromocriptine
Vitamin B12
33. Common side effect of Rifampin
Calcium
Primaquine
Desflurane
Red urine discoloration
34. SE of OCs
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Increased thromboembolic events
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Lithium toxicity
35. Peakless ling acting insulin
Ultralente (humulin U)
GFR
Insulin glargine
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
36. MOA of class IV antiarrhythmics
Chlordiazepoxide and Diazepam
Acetazolamide
Prednisone
Calcium channel blockers
37. Inhaled anesthetics are myocardial depressants
Enflurane and halothane
Ephedrine
Ticlopidine
Meperidine
38. Nonselective alpha agonists that increases outflow - probably via the uveoscleral veins
Epinephrine - dipivefrin
Carbamazepine
Amrinone and milrinone
Potassium channel blockers
39. Class of drugs that may cause cross - sensitivity with thiazide diuretics
Thick ascending limb
Cyproheptadine
Sulfonamides
Bromocriptine
40. Alkylating agent - vesicant that causes tissue damage with extravasation
Lithium
Mechlorethamine
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Ticlopidine
41. Block cardiac adverse effects of thyrotoxicosis such as tachycardia - inhibits the conversion of T4 to T3
Phase I
Beta - blockers such as propranolol
GLUT 2
Deferoxamine
42. Captopril and enalapril (- OPRIL ending) are
Selective inhibitor of microtubule assembly
ACE inhibitors
Beta - blockers
Carbenicillin - piperacillin and ticarcillin
43. Most common side effect of 1st generation antihistamines
Amphetamines
Hydroxychloroquine
Sedation
ACE inhibitors
44. Neurotransmitters affected by the action of antidepressants
Low therapeutic index
Norepinephrine and serotonin
Ketamine
Pyridostigmine
45. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Dantrolene
Celecoxib
Bleomycin
46. Regimen used for breast cancer
ORAL vancomycin
Physostigmine
Haloperidol or pimozide
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
47. Cardioselective Beta 1- blockers
Atenolol - acebutolol - and metoprolol
Capsaicin
Chloramphenicol
Aminocaproic acid
48. Reason fluoroquinolones are contraindicated in children and pregnancy
Cartilage damage
Succinylcholine
Bone marrow and teeth discoloration for children under 8 years of age
nephro and ototoxicity
49. Peptide causing increased capillary permeability and edema
Vincristine
Bile acid - binding resins
Cyclobenzaprine
Bradykinin and histamine
50. Block glycoprotein IIb/IIIa involved in platelet cross - linking
Abciximab - tirofiban and eptifibatide
Degradation of fibrin clots and are administered IV
ED50
Calcium channel blockers