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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Local anesthetic with vasoconstrictive property - favored for head - neck - and pharyngeal surgery
Calcium channel blockers
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Cocaine
inhibits HMG COA reductase
2. Neurologic SE of benzodiazepines
Clomiphene and tamoxifen
Anterograde amnesia
Adalimumab - infliximab and etanercept
Flunitrazepam (rohypnol)
3. ABVD regimen used for HD - but appears less likely to cause sterility and secondary malignancies than MOPP
lispro insulin - aspart insulin - glulisine insulin
Nephro and ototoxicity
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Thioamides - iodides - radioactive iodine - and ipodate
4. Beta - blockers should be used cautiously in
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Heroin - morphine - oxycodone - meperidine and fentanyl
Glucuronate - acetic acid - and glutathione sulfate
Metronidazole
5. Antivirals associated with neutropenia
Ganciclovir - zidovudine - saquinavir - and interferon
Neuromuscular blocking drugs
Aspirin
G- CSF (filgrastim) and GM- CSF (sargramostim)
6. Leads to respiratory depression progressing to coma and death
Bioavailability (F)
Overdose of opioids
Zafirlukast and montelukast
Terbutaline
7. Increase bone density - also being tested for breast CA prophylaxis
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Raloxifene (SERM- selective estrogen receptor modulator)
Echothiophate
Olanzapine
8. MOA of thiazide diuretics
Work at early distal convoluted tubule
Inhibit Na+/Cl - cotransport
Uterine contractions
Epinephrine - dipivefrin
9. Ability to produce less than 100% of the response
Citalopram and its metabolite escitalopram
Peripheral neuritis and hepatitis
Tetracaine and bupivacaine
Partial agonist
10. Sedative - Hypnotics action
Reduce inhibition - suppress anxiety - and produce relaxation
Arginine
Metrifonate
Skeletal muscle tremor - tachycardia
11. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Acebutolol - atenolol - esmolol - metoprolol
Prednisone
Cholinesterase regenerators - pralidoxime
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
12. Beta 1 agonist toxicity
PTU
Phentolamine
Sinus tachycardia and serious arrhythmias
Venlafaxine
13. MOA of corticosteroids
Propoxyphene
inhibit phospholipase A2
Atenolol - acebutolol - and metoprolol
Administration of Vit. B6 (pyridoxine)
14. DOC for giardia - bacterial vaginosis - pseudomembranous colitis - and trichomonas
Metronidazole
Celecoxib
Venlafaxine
Reducing preload
15. Agent used for neurological deficits in megaloblastic anemia
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Vitamin B12
Regular (Humulin R)
Salmeterol
16. MOA of class IV antiarrhythmics
Organic nitrites
Cisplatin
Calcium channel blockers
2 to 3 weeks
17. MOA of sildenafil (Viagra)
SSRIs
Physostigmine
Flunitrazepam (rohypnol)
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
18. Clinical response that may fluctuate in tx of Parkinson's dx
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19. Inhalant anesthetics
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
NO - chloroform - and diethyl ether
Bile acid - binding resins
Nevirapine - amprenavir
20. Main route of metabolism for benzodiazepines
Vitamin K or fresh frozen plasma
CNS stimulation; GI upset
Hepatic
Doxepin
21. SSRI indicated for premenstrual dysphoric disorder
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Fluoxetine (Sarafem)
Xanthine oxidase
Imipramine
22. The most frequent cause of acute deaths in cholinesterase inhibitor toxicity
Norepinephrine and serotonin
Timolol (nonselective) - betaxolol (selective)
Desmopressin (DDAVP)
Respiratory failure
23. Vitamin K dependent anticoagulant
Flumazenil
Clomipramine
ORAL vancomycin
Warfarin (PT)
24. Agents used in Tourette's dx
Flumazenil
First order kinetics
Haloperidol or pimozide
Hypoglycemia
25. Produces disulfiram - like reaction with ethanol
Adenosine
Citalopram and its metabolite escitalopram
Fluoxetine
Procarbazine
26. SE of ergot alkaloids
Hallucinations resembling psychosis
Reducing progression of heart failure (never use in acute heart failure)
Midazolam
Risperidone
27. Relates the amount of drug in the body to the plasma concentration
Constipation - edema - and headache
Therapeutic index
Volume of distribution (VD)
Glucagon
28. Well - tolerated and are first - line antidepressants
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29. Beta 2 agonist toxicity
Dextroamphetamines and methamphetamine
Skeletal muscle tremor - tachycardia
Methicillin - nafcillin - and dicloxacillin
Interleukin 11 (oprelvekin)
30. Agents having higher sedation and antimuscarinic effects than other TCA's
Fluorocarbons and Industrial solvents
Neuroleptanesthesia
Tertiary amines
Use in IgE mediated allergic reaction
31. Peakless ling acting insulin
Carboplatin
Insulin glargine
Benzodiazepines and calcium channel blockers
Diazepam
32. Common side effect of Rifampin
Hypoglycemia
Red urine discoloration
Thick ascending limb
Hallucinations resembling psychosis
33. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine
Gynecomastia hyperkalemia - and impotence
Insulin
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Sodium channel blockade
34. Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)
First pass effect
Severe hypertension
Combination oral contraceptives (OC)
Pralidoxime - atropine
35. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
NSAIDS
Nausea
Zafirlukast and montelukast
Interleukin 11 (oprelvekin)
36. Prevents thrombosis in patients with artificial heart valve
Flumazenil
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Dipyridamole
Temazpam - trizolam - flurazepam
37. Antipsychotic having the strongest autonomic effects
Thioridazine
Autocoids
sulfamethoxazole/ trimethoprim
Dextroamphetamines and methamphetamine
38. B- blockers that are more cardioselective
Indomethacin
Pregnancy
Beta -1 selective blockers
Side - effect profile and prior pt response
39. The most important sign of withdrawal syndrome
N- acetylcysteine
Reduce aqueous secretion
Venlafaxine
Excessive CNS stimulation (seizures)
40. Dopamine (DA) agonist (for Parkinson's disease) - used also for hyperprolactinemia
Bromocriptine
Carbamazepine
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
Erythropoietin
41. Thiazolidinediones
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Naloxone (IV) - naltrexone (PO)
Diphenoxylate - Loperamide
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
42. Products of Phase II conjugation
Somatrem
Glucuronate - acetic acid - and glutathione sulfate
Long acting cholinesterase inhibitors
Ephedrine
43. Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
Etidronate
Carbidopa
Flunitrazepam (rohypnol)
Phenobarbital
44. Major route of elimination for Lithium
Gingival hyperplasia - nystagmus - diplopia and ataxia
Calcium channel blockers
Abciximab - tirofiban and eptifibatide
Kidneys
45. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease
Spasmolytic drugs
Maintenance dose (Cp*(CL/F))
Potency
Pre - existing cardiac or renal disease
46. Oral contraceptive available in a transdermal patch
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Thioridazine
Ortho - Evra
Long acting cholinesterase inhibitors
47. Tubocurarine is the prototype - pancuronium - atracurium - vecuronium are newer short acting agent - produce competitive block at end plate nicotinic receptor - causing flaccid paralysis
Nondepolarizing Neuromuscular Blockers
high doses
Clonazepam
Dicyclomine - methscopolamine
48. Atypical antipsychotic causing high prolactin levels
Megaloblastic anemia
First order kinetics
Risperidone
Finasteride (Proscar and Propecia respectively)
49. Opioid antagonist that is given orally in alcohol dependency programs
Naltrexone
Dopamine blockade
prolongs QT and PR interval
inhibits HMG COA reductase
50. LA causing methemoglobinemia
Thyroid and steroid hormones
Prilocaine
Leuprolide
Vitamin K and Fresh frozen plasma (FFP)