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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Thrombolytics are used for
Amitriptyline
Pulmonary embolism and DVT
Diazepam
Hot flashes
2. Toxicity of amphotericin
Desmopressin (DDAVP)
Cimetidine
Nephrotoxicity
Adenosine
3. SE of lithium
Hydroxychloroquine
Megaloblastic anemia
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Vancomycin - infusion at a slow rate and antihistamines
4. Drug of choice for leprosy
Dapsone - rifampin and clofazimine combination
First generation due to being more lipid - soluble
Digibind
Leuprolide
5. Nitroprusside vasodilates
Ototoxicity
Arteries and veins
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
6. SE of minoxidil
Hypertrichosis
PCP
Vitamin B12
prolongs QT and PR interval
7. MOA of penicillin
Torsades de pointes
Radioactive iodine
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
First generation due to being more lipid - soluble
8. Meglitinide class of drugs
Mifepristone (RU-486)
Volume of distribution (VD)
Clindamycin
Repaglinide
9. Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
Erythromycin
Etidronate
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Nitrites
10. System that increases in activity with chronic ethanol exposure and may contribute to tolerance
Phentolamine
EOS
Additive CNS depression
Methimazole and propylthiouracil (PTU)
11. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Digoxin
Cyproheptadine
Valproic acid - carbamazepine - phenytoin and gabapentin
Hydroxychloroquine
12. MOA for Ethosuximide
Calcium channels
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Ketoconazole
Pilocarpine - carbachol - physostigmine
13. Antidote to reverse actions of warfarin
Positive Comb's test - depression
5-7 days
Vitamin K or fresh frozen plasma
Glyburide - glipizide - glimepiride - etc.
14. GnRH antagonist with more immediate effects - used for infertility
Ganirelix
Clopidogrel and ticlopidine
Dipyridamole
Nausea
15. Agents used in Tourette's dx
Haloperidol or pimozide
Midazolam
Dantrolene
Nephro and ototoxicity
16. SE of thiazide (HCTZ) diuretics
Carvedilol
Celecoxib
N- acetylcysteine
Hyperuricemia - hypokalemia and hyperglycemia
17. Inducers of Cytochrome P450 (CYP450)
Barbiturates - phenytoin - carbamazepine - and rifampin
Hepatotoxicity
Glucagon
Ribavirin
18. MOA of tetracycline
Thick ascending limb
Decreases protein synthesis by inhibiting 30S ribosome
Neostigmine
Ketanserin cyproheptadine - and phenoxybenzamine
19. Long acting insulin
Tricyclic antidepressants (TCA)
Ultralente (humulin U)
Nifurtimox
TD50
20. SE for ticlopidine
Neutropenia and agranulocytosis
Lithium toxicity
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Acarbose - miglitol
21. Carbonic anhydrase inhibitor
Acetazolamide
Aztreonam
Cocaine 'super - speed'
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
22. Different steps of Phase I
Carvedilol
hydroxyzine (Atarax)
Oxidation - reduction - hydrolysis
Nitroprusside
23. Very rapid acting insulin - having fastest onset and shortest duration of action
Hydration and mercaptoethanesulfonate (MESNA)
Gynecomastia
Cephalosporins
Lispro (Humalog) - aspart - glulisine
24. Generation of antihistamine that has the most CNS effects
Prazosin - terazosin and doxazosin (- AZOSIN ending)
First generation due to being more lipid - soluble
Raloxifene
Amiodarone
25. Used intranasally and decreases bone resorption
Calcitonin (salmon prep)
Tissue plasmin activator
6- mercaptopurine (6- MP)
Aminoglutethimide
26. Alpha 1selective blockers
Buprenorphine
Cocaine
Midazolam
Prazosin - terazosin and doxazosin (- AZOSIN ending)
27. Inhibitors of CYP450
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Increase the DURATION of GABA- mediated chloride ion channels
Metronidazole
Efficacy
28. IV barbiturate used as a pre - op anesthetic
Nifedipine
Work at early distal convoluted tubule
Thiopental
Buspirone
29. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)
Peripheral neuritis and hepatitis
Noncompetitive antagonist
Cyanocobalamin (Vit B12)
Entacapone and Tolcapone
30. Combined alpha and beta blocking agents that may have application in treatment of CHF
Meperidine
Hepatotoxicity
Labetalol and carvedilol
6- mercaptopurine (6- MP)
31. Amount of drug necessary to elicit a biologic effect; refers to the drug's strength
Pilocarpine
Rebound HTN - sedation - dry mouth
Potency
Cyproheptadine
32. Microtubule inhibitor that causes peripheral neuropathy - foot drop (eg. ataxia) - and 'pins and needles' sensation
Chloramphenicol
Vincristine
Phenobarbital
Tinnitus - GI bleeding
33. Pyrimidine analog that causes 'Thymine - less death' given with leucovorin rescue
5- flouracil (5- FU)
Deferoxamine
Salmeterol
Apraclonidine - brimonidine
34. Agent used in shock because it dilates coronary arteries and increases renal blood flow
Alprazolam and Clonazepam
Insulin release from pancreas by modifying K+ channels
Dopamine
Lithium toxicity
35. SE for ganciclovir
Salmeterol
Neutro - leuko and thrombocytopenia
Pramipexole and ropinirole
Aminoglutethimide
36. Regimen used for non - Hodgkin's lymphoma
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Finasteride (Proscar and Propecia respectively)
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
TD50
37. Primary endogenous substrate for Nitric Oxidase Synthase
Arginine
Haloperidol
Ketamine
Classic
38. NSAID that is used for acute condition - such as pre - op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
Ketoralac
Paclitaxel (taxol)
Ethosuximide and valproic acid
Atropine - pralidoxime (2- PAM)
39. Drug used in ergot alkaloids overdose - ischemia and gangrene
Bromocriptine
Vitamin K and Fresh frozen plasma (FFP)
Nitroprusside
Dicyclomine - methscopolamine
40. 3 zones of adrenal cortex and their products
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Beta blockers
Pulmonary embolism and DVT
Selective inhibitor of microtubule assembly
41. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis
Phase I
Bleomycin
Dimercaprol
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
42. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors
PGE1
Regular (Humulin R)
Capsaicin
Octreotide
43. Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because
Estogens increase maternal TBG
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Dopamine blockade
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
44. Longer acting Beta 2 agonist is recommended for prophylaxis of asthma
Nitroprusside
Salmeterol
Sedation
Na+/K+ exchange
45. SE of phenytoin
EOS
Gingival hyperplasia
Ethanol
Glucagon
46. Antibiotic causing red - man syndrome - and prevention
Streptokinase
Bupropion
Hypokalemia
Vancomycin - infusion at a slow rate and antihistamines
47. Drugs available in combination with metformin
Glyburide - glipizide - and rosiglitazone
block SLUD (salivation - lacrimation - urination - defecation
Postsynaptic Mu receptors
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
48. Prostaglandins that cause abortions
Arginine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Venlafaxine
Ethosuximide and valproic acid
49. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
Tertiary amines
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Selegiline
Haloperidol
50. CCB are DOC for
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