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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Direct vasodilator of arteriolar smooth muscle
Hydralazine
Nitrites
Oxytocin - ergonovine and ergotamine
Carbidopa
2. Thiazolidinediones
Normal C- peptide
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Methotrexate
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
3. SE of niacin
Cutaneous flush
Spasmolytic drugs
Irreversibly blocking cyclooxygenase
Dantrolene
4. Antidote used for warfarin toxicity
Pulse therapy
Vitamin K and Fresh frozen plasma (FFP)
Alkylating agent
Aminocaproic acid
5. Benzodiazepine used for anxiety
Nandrolone - oxymetholone - and oxandrolone
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Alprazolam
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
6. Secondary amines that have less sedation and more excitation effect
Excessive hypotension and kidney failure
Nortriptyline - Desipramine
Heroin - morphine - oxycodone - meperidine and fentanyl
Ototoxicity
7. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Decrease arterial blood pressure
Buprenorphine
Hyperkalemia
Glucagon
8. COX 2 inhibitors may have reduced risk of
Seizures
Gastric ulcers and GI Bleeding
Disulfiram - like reaction
Malathion
9. MOA for benzodiazepines
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Cimetidine
Aspirin - Nitrates - CCB - and Beta blockers
Raloxifene (SERM- selective estrogen receptor modulator)
10. Drug of choice for leprosy
Amiodarone
Vitamin K or fresh frozen plasma
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Dapsone - rifampin and clofazimine combination
11. Anti - seizure drugs used also for pain of neuropathic orgin
Ethinyl estradiol and mestranol
Gabapentin
GLUT 2
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
12. Most important toxic effects of most local anesthetics
Maintenance dose (Cp*(CL/F))
LD50
CNS toxicity
Abstinence syndrome
13. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
Beta -1 selective blockers
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Levodopa
Ferrous sulfate
14. Agent with zero - order kinetics
Entacapone and Tolcapone
Leucovorin
Cefixime (3rd) generation
Ethanol
15. Class of drugs that reversibly inhibit COX
Adenosine
PTU
Atropine
NSAIDS
16. Anti - rheumatic agent also used for Chron's disease
Naloxone (IV) - naltrexone (PO)
ED50
Infliximab
Dimenhydrinate - meclizine - and other 1st generation
17. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
L- dopa
LD50
Timolol (nonselective) - betaxolol (selective)
Allopurinol
18. Amount of drug necessary to elicit a biologic effect; refers to the drug's strength
Terbutaline
Bleeding
Potency
Buspirone
19. Time it takes for amount of drug to fall to half of its value; this is a constant in first order kinetics (majority of drugs)
Glucagon
Half - life (T1/2)
Oral and transdermal forms of nitroglycerin
Carboplatin
20. Methyldopa is contraindicated in
Ascending pathways
Mirtazapine
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Geriatrics due to its CNS (depression) effects
21. Phenylisopropylamines that are used legitimately and abused for narcolepsy - attention deficit disorder - and weight reduction
Amphetamines
Gynecomastia and hyperkalemia
Selective inhibitor of microtubule assembly
Valproic acid
22. Used intranasally and decreases bone resorption
Oral
Calcitonin (salmon prep)
Hepatic enzymes
Gynecomastia and hyperkalemia
23. Agent used neutropenia especially after chemotherapy
G- CSF (filgrastim) and GM- CSF (sargramostim)
Malathion
Beta1 agonists
Trazodone
24. GABA agonist in the spinal cord
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Aspirin
Gynecomastia
Baclofen
25. Neurologic SE of benzodiazepines
Midodrine
Lorazepam - oxazepam - and temazepam
Prednisone
Anterograde amnesia
26. Toxicities include nephrotoxicity and ototoxicity - leading to a severe interaction with aminoglycosides
Deferoxamine
Hydroxychloroquine
Propranolol
Cisplatin
27. Epinephrine is often mixed with a local anesthetic to
Glargine (Lantus) - detemir
Reduce the loss from area of injection
Celecoxib and rofecoxib
Nitrous oxide
28. Maximum response achieveable from a drug
Efficacy
sulfamethoxazole/ trimethoprim
100% O2 and hyperbaric O2
Dantrolene
29. MOA of corticosteroids
Amphetamines
Pilocarpine - carbachol - physostigmine
inhibit phospholipase A2
Hepatic
30. Non - benzodiazepine used as an anxiolytic
Mannitol
Buspirone
Older antipsychotic agents - D2 receptors
Metronidazole
31. Antidepressant associated with seizures and cardiotoxicity
Metronidazole
Cimetidine
Maprotiline
Buspirone
32. Anticancer drug also used in RA - produces acrolein in urine that leads to hemorrhagic cystitis
Pentoxifylline
Cyclophosphamide
Fluoxetine (Sarafem)
prolongs QT and PR interval
33. Intermediate acting glucocorticoids
Hepatic toxicity
Beta blockers
Streptomycin
Prednisone - methylprednisolone - prednisolone - and triamcinolone
34. Antiglaucoma organophosphate
Steroids
Decreased micro and macro vascular disease
Echothiophate
Pindolol and acebutolol
35. Agent used for closure of patent ductus arteriosus
GLUT 2
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Indomethacin
Lithium
36. Prototypical drug is atropine
Minocycline
Propranolol
Nonselective Muscarinic Antagonists
Epinephrine
37. Non - selective Beta - blocker also used for migraine prophylaxis
Combination oral contraceptives (OC)
Propranolol
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Dopamine blockade
38. SE of heparin
Carbidopa
Serotonin syndrome
Dexamethasone suppression test
Heparin induced thrombocytopenia (HIT)
39. Treatment for TB patients (think RIPE)
Cortisone and hydrocortisone (equivalent to cortisol)
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Penicillamine
Older antipsychotics
40. Most frequent route of metabolism
Lactic acidosis
Olanzapine
Imipramine
Hepatic enzymes
41. Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA
Acute intermittent porphyria
Tissue plasmin activator
Clonidine - and methyldopa
Gingival hyperplasia - nystagmus - diplopia and ataxia
42. This agent may cause more severe - rapid and intense symptoms to a recovering addict
Mast cell stabilizer
Hyperuricemia - hypokalemia and hyperglycemia
Presynaptic mu - delta - and kappa receptors
Naloxone
43. Well - tolerated and are first - line antidepressants
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44. Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Dimenhydrinate - meclizine - and other 1st generation
LSD
Estogens increase maternal TBG
45. SE of ACE inhibitors
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Reducing progression of heart failure (never use in acute heart failure)
Adenosine
Dry cough - hyperkalemia
46. Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and prophylaxis in women with risk factors for breast cancer
Raloxifene
Celecoxib and rofecoxib
Zero order kinetics
Epinephrine
47. The most frequent cause of acute deaths in cholinesterase inhibitor toxicity
Acute intermittent porphyria
'On - off - phenomenon'
Respiratory failure
Little C- peptide
48. HMG CoA reductase inhibitors are contraindicated in
Decreased micro and macro vascular disease
Insulin glargine
Insulin
Pregnancy
49. Vitamin K dependent anticoagulant
Salmeterol
Warfarin (PT)
Cp
Half - life (T1/2)
50. This is the drug of choice for anaphylactic shock
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Cortisone and hydrocortisone (equivalent to cortisol)
Epinephrine
Phenylephrine