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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Common SE of tamoxifen and raloxifene
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Hot flashes
Peripheral neuritis and hepatitis
Gingival hyperplasia
2. Drug used for N. gonorrhea in females
Ceftriaxone
Beta blockers
Cholinesterase inhibitors
Leuprolide
3. Antidote used for tricyclic antidepressants (TCA)
PTU
Sodium bicarbonate
Presynaptic mu - delta - and kappa receptors
Valproic acid and Phenytoin
4. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Halothane and methoxyflurane
high doses
5. Used for Cushing's syndrome (increased corticosteroid)
Dopamine
Pilocarpine
Opioid Analgesics
Dexamethasone suppression test
6. Nonselective alpha - blocking drug - long acting and irreversible - and used to treat pheochromocytoma. Blocks 5- HT - so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis
Autocoids
Phenoxybenzamine
Enflurane and halothane
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
7. TCA used in chronic pain - enuresis - and ADD
Zileuton
prolongs QT and PR interval
Acyclovir; incorporated into viral DNA and chain termination
Imipramine
8. Agent for pernicious anemia
Cyanocobalamin (Vit B12)
Adenosine
Alprostadil
Oral
9. Common side effect of Rifampin
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Epinephrine
Red urine discoloration
Hyperkalemia
10. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Interleukin 11 (oprelvekin)
Aspirin
Reducing preload
Isoflurane
11. Opioid associated with respiratory depression - but is used in high risk patients who may not survive full general anesthetia
Loading dose (Cp*(Vd/F))
Lactic acidosis
Fentanyl
LD50
12. Permanently cures thyrotoxicosis - patients will need thyroid replacement therapy thereafter. Contraindicated in pregnancy
Radioactive iodine
First order kinetics
Phase I
Ribavirin
13. MOA of loop diuretics
Isoflurane
inhibits Na+/K+/2Cl - cotransport
Suramin
LD50
14. Methyldopa is contraindicated in
Dobutamine
Gingival hyperplasia
Nitrous oxide
Geriatrics due to its CNS (depression) effects
15. Anti - androgen used for prostate cancer
Ethosuximide and valproic acid
Indomethacin
Flutamide (Eulexin)
Pralidoxime
16. Agents having higher sedation and antimuscarinic effects than other TCA's
5-7 days
Oxytocin
Acarbose - miglitol
Tertiary amines
17. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction
Regular (Humulin R)
Parathion
Pilocarpine - carbachol - physostigmine
lispro insulin - aspart insulin - glulisine insulin
18. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Meperidine
Nonselective Muscarinic Antagonists
Risperidone
GLUT 4
19. Life threatening cardiac event that prolong QT leads to
Torsades de pointes
Clomipramine - fluoxetine and fluvoxamine
Ceftriaxone or cefuroxime
N- acetylcysteine (Mucomyst)
20. Drug of choice for myoclonic seizures
G- CSF (filgrastim) and GM- CSF (sargramostim)
Tetracaine and bupivacaine
Valproic acid
Spironolactone
21. NSAID used in gout
Indomethacin
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Prolongs QT interval
Cholinesterase inhibitors
22. Non - selective Alpha1blockers use to treat pheochromocytoma
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Aplastic anemia and renal toxicity
Beta - blockers
Phenoxybenzamine
23. SE of clonidine
Deferoxamine
Seizures
Rebound HTN - sedation - dry mouth
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
24. HIV med used to reduce transmission during birth
AZT (zidovudine)
Pre - existing cardiac or renal disease
Dry cough
Cyanide toxicity treated with sodium thiosulfate
25. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Potency
PGE1
6- mercaptopurine (6- MP)
Bupropion
26. Anticancer drug also used in RA - produces acrolein in urine that leads to hemorrhagic cystitis
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Nadolol
First pass effect
Cyclophosphamide
27. SE of OCs
Midazolam
CNS depressants
GABA- related targets
Increased thromboembolic events
28. Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis
Na+/K+ exchange
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
Bleeding
Desmopressin (DDAVP)
29. Irreversible condition resulting from the use of antipsychotics - reserpine at high doses - and MPTP (by- product of illicit meperidine analog)
Drug induced Parkinsonism
Neostigmine
Hypertension
Phase I
30. Treatment of myasthenia gravis
Rescue therapy
Cerebral hemorrhage
Classic
Pyridostigmine
31. Agents that reduce heart rate - contractility - and O2 demand
Olanzapine - aripiprazole - and sertindole
Beta - blockers
Log - kill hypothesis
Chlordiazepoxide and Diazepam
32. Mast cells to reduce release of hisamine and inflammatory mediators
Epinephrine
Desmopressin (DDAVP)
Amantadine
Glyburide - glipizide - and rosiglitazone
33. Prototype antagonist of H1 and H2 receptors
Ceftriaxone or cefuroxime
Diphenhydramine and cimetridine - respectively
Aldehyde dehydrogenase
Monamine oxidase inhibitors
34. GHRH analog used as diagnostic agent
Oxytocin
Sermorelin
G- CSF (filgrastim) and GM- CSF (sargramostim)
Epinephrine - dipivefrin
35. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Ephedrine
Ketamine
Protamine
36. ACTH analog used for diagnosis of patients with corticosteroid abnormality
Warfarin (PT)
Cosyntropin
Sumatriptan
Bioavailability (F)
37. H1 antagonist used in motion sickness
Ipratropium
Calcium
Dimenhydrinate - meclizine - and other 1st generation
Minoxidil
38. Interferes with activity of T- lymphocytes
Hydroxychloroquine
First order kinetics
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Sulfonamides
39. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure
Toremifene (Fareston)
Ferrous sulfate
Nefazodone
Ondansetron - granisetron - dolasetron and alosetron
40. Most widely used thyroid drugs such as Synthroid and Levoxyl contain
L- thyroxine (T4)
Alkylating agent
Antithrombin 3
Octreotide
41. Bronchodilation in asthma and COPD
Nevirapine - amprenavir
Procarbazine
Ipratropium
Pilocarpine - carbachol - physostigmine
42. Skeletal muscle agent that undergoes Hofmann elimination (breaks down spontaneously)
Atracurium
Loading dose (Cp*(Vd/F))
Kidney and liver toxicity - diarrhea
Zollinger - Ellison Syndrome
43. Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Baclofen
Lactic acidosis
Combination oral contraceptives (OC)
44. Chelating agent used in Wilson's disease
Fluorocarbons and Industrial solvents
Cortisone and hydrocortisone (equivalent to cortisol)
Penicillamine
Torsades de pointes
45. Type of kinetics when a constant percentage of substrate is metabolized per unit time
Sodium channel blockers
Steroids
B- blockers
First order kinetics
46. Selectivity of a drug for its receptor
Specificity
Aspirin
Ticlopidine
Thyroxine
47. Agent used for closure of patent ductus arteriosus
Vincristine
Dicyclomine - methscopolamine
Indomethacin
Nitrous oxide
48. Hormone inhibiting prolactin release
Dopamine
Succinylcholine
Rhabdomyolysis
Ketoralac
49. Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because
Stimulates cGMP which leads to vascular smooth muscle relaxation
high doses
Estogens increase maternal TBG
Rebound HTN - sedation - dry mouth
50. Meningitis prophylaxis in exposed patients
Rifampin
Hypoglycemia
Finasteride (Proscar and Propecia respectively)
Nondepolarizing Neuromuscular Blockers