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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Digoxin toxicity can be precipitated by
Lispro (Humalog) - aspart - glulisine
Hypokalemia
Calcium
Protamine sulfate
2. Drug used in exoerythrocytic cycle of malaria
Corticosteroids
Thioridazine
Primaquine
Acebutolol and atenolol
3. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Prazosin - terazosin - doxazosin
Phenoxybenzamine
Estrogen
Bupropion
4. Uses of bisphosphonates
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5. Important in synthesis of glucose to glycogen in the liver
Interferon alpha
Spironolactone
GLUT 2
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
6. Atropine fever is the most dangerous effect and can be lethal in this population group
Low potency phenothiazines and ziprasidone
Aspirin
Rescue therapy
Infants
7. MOA of tetracycline
Dimercaprol
Terfenadine and astemizole (have been removed from the market)
Decreases protein synthesis by inhibiting 30S ribosome
L- asparaginase
8. MOA of nystatin
Spasmolytic drugs
Doxepin
Patches - gum - nasal spray - psychotherapy - and bupropion
Bind ergosterol in fungal cell membrane
9. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
Primaquine
Sodium bicarbonate
Bromocriptine
Amrinone and milrinone
10. Aspirin reduces mortality in unstable angina by
Risperidone
Platelet aggregation inhibition
Neutropenia and agranulocytosis
Minimum alveolar anesthetic concentration (MAC)
11. Benzodiazepines that are the most effective in the treatment of panic disorder
Adalimumab - infliximab and etanercept
Alprazolam and Clonazepam
Flumazenil
Prazosin - terazosin - doxazosin
12. Target plasma concentration times (volume of distribution divided by bioavailability)
Ganciclovir - zidovudine - saquinavir - and interferon
First generation due to being more lipid - soluble
Gingival hyperplasia - nystagmus - diplopia and ataxia
Loading dose (Cp*(Vd/F))
13. MOA of penicillin
Thioridazine
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Streptomycin
Iodide salts
14. Concern using lithium
Ganirelix
Amantadine
Low therapeutic index
N- acetylcysteine (Mucomyst)
15. Hormone inhibiting prolactin release
Probenecid and sulfinpyrazone
Infants
Dopamine
Raloxifene (SERM- selective estrogen receptor modulator)
16. MOA of AGI's
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Acetazolamide
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
2 to 3 weeks
17. Anti - seizure medication also used in the prevention of migraines
Cocaine
Lepirudin
Valproic acid
Oxytocin
18. SE of acetazolamide
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Arteries and veins
Acetazolamide
Elderly patients
19. MOA of class IV antiarrhythmics
Calcium channel blockers
Adalimumab - infliximab and etanercept
Physostigmine
Pulse therapy
20. Occurs when sedative hypnotics are used chronically or at high doses
Atropine
Tolerance
Dopamine blockade
Inhibits osteoclast bone resorption
21. Non - depolarizing skeletal muscle antagonist that has short duration
Vitamin K or fresh frozen plasma
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Excessive CNS stimulation (seizures)
Mivacurium
22. Opioid used in the management of withdrawal states
Methadone
Maprotiline
Most are thought to act at GABA- A receptor - chloride channel
Raloxifene
23. A1a - selective blocker with no effects on HTN used for BPH
Verapamil
Tamsulosin (Flomax)
Haloperidol
Arteries and veins
24. Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and prophylaxis in women with risk factors for breast cancer
Torsades de pointes
Raloxifene
Risperidone
Carmustine (BCNU) and lomustine (CCNU)
25. Antiprogestin used as potent antagonist of GC receptor
IV and IM (only LMW)
6- mercaptopurine (6- MP)
Mifepristone
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
26. Secondary amines that have less sedation and more excitation effect
Ethanol
Dipyridamole
Metronidazole
Nortriptyline - Desipramine
27. Long acting insulin
Dopamine
Ultralente (humulin U)
Efficacy
GLUT 2
28. Median toxic dose required for a toxic effect in 50% of the population
Vitamin B12
Dapsone - rifampin and clofazimine combination
Hydroxychloroquine
TD50
29. MOA of class III antiarrhythmics
Potassium channel blockers
Ketanserin cyproheptadine - and phenoxybenzamine
Quetiapine
Capsaicin
30. This agent used to treat dry mouth in Sj
Esmolol
Cevimeline
CNS toxicity
Ezetimibe (Zetia)
31. Causes acne - premature closure of epiphyses - masculinization in females - hepatic dysfunction - MI - and increases in libido and aggression
Glucagon
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Steroids
Paclitaxel (taxol)
32. HIV med used to reduce transmission during birth
AZT (zidovudine)
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Rifampin
B- blockers
33. Antidote used for heparin overdose
Volume of distribution (VD)
Prostaglandin PGF2a
Propranolol
Protamine
34. Drugs of choice for status epilepticus
Corticosteroids
Aldehyde dehydrogenase
Phase I
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
35. Antidote used for beta agonist toxicity (eg. Metaproterenol)
Esmolol
Glucuronate - acetic acid - and glutathione sulfate
Disulfiram
Glyburide - glipizide - and rosiglitazone
36. Increase bone density - also being tested for breast CA prophylaxis
Raloxifene (SERM- selective estrogen receptor modulator)
Tetracaine and bupivacaine
Fluoxetine (Sarafem)
Calcium channel blockers
37. Mast cells to reduce release of hisamine and inflammatory mediators
Epinephrine
Dextromethorphan - Codeine
Morphine and fentanyl
Tamsulosin (Flomax)
38. Agent which stimulates cardiac contractile force more than rate with little effect on total peripheral resistance
Lactic acidosis
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Dobutamine
Benzodiazepines and calcium channel blockers
39. Antidote used for lead poisoning
Fluoxetine
Dimercaprol - EDTA
Hypertensive crisis
Demeclocycline
40. Warfarin is contraindicated in
Pregnancy
Labetalol and carvedilol
Leucovorin
Ketoralac
41. Concurrent use of fibrates and statins increases risk of
Rhabdomyolysis
GLUT 4
Amantadine
Constipation - edema - and headache
42. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Seizures
Theophylline
Interleukin 11 (oprelvekin)
Hypokalemia
43. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
EOS
Prolonged half - life - up to six weeks
Ethanol
Tubocurarine
44. Cholestyramine and colestipol are
Inhibition of protein synthesis at the 50s subunit of ribosome
Bile acid - binding resins
Halothane
Odansetron
45. Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage - cardiac arrhythmias - and myocardial infarction
Spasmolytic drugs
Levodopa
Cocaine
Reducing preload
46. Common mechanism by which overdose result in death
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Fludrocortisone and deoxycorticosterone
Ethanol
Depression of medullary and cardiovascular centers
47. Toxicity of organophosphate:
Potency
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
inhibits HMG COA reductase
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
48. SE of CCB
Constipation - edema - and headache
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Echothiophate
Mifepristone (RU-486)
49. Irreversible - nonselective COX inhibitor
Aspirin
Morphine - methadone - meperidine - and fentanyl
Mirtazapine
Thioridazine
50. These agents are used as antitussive
Metrifonate
Opioid Analgesics
Dextromethorphan - Codeine
Cholinesterase regenerators - pralidoxime