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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Relates the amount of drug in the body to the plasma concentration






2. Inhibit angiotensin - converting enzyme (ACE)






3. Metronidazole SE if given with alcohol






4. HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism






5. Antidote used for cyanide poisoning






6. Permanently cures thyrotoxicosis - patients will need thyroid replacement therapy thereafter. Contraindicated in pregnancy






7. Chronic orthostatic hypotension can be treated with






8. SE of beta blockers






9. This may enhance activity of local anesthetics






10. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock






11. Beta - blockers should be used cautiously in






12. Non ergot agents used as first - line therapy in the initial management of Parkinson's






13. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis






14. Selective Alpha 1 blocker used for hypertension - BPH - may cause first dose orthostatic hypotension






15. Most common SE of fibrates






16. Antiglaucoma organophosphate






17. Rate limiting step of alcohol metabolism






18. Local anesthetic with vasoconstrictive property - favored for head - neck - and pharyngeal surgery






19. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)






20. 5 alpha - reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness






21. MOA of corticosteroids






22. Anti - thyroid drugs






23. Mast cells to reduce release of hisamine and inflammatory mediators






24. Anti - seizure drugs used as alternative drugs for mood stabilization






25. Occurs when sedative hypnotics are used chronically or at high doses






26. Anti - biotic frequently used for chronic UTI prophylaxis






27. SE of Aspirin






28. SE of demeclocycline






29. CCB with predominate effect on arteriole dilation






30. MOA of sildenafil (Viagra)






31. Thiazolidinediones






32. MOA of nesiritide






33. 'Date rape drug'






34. MOA of drug or foods (grapefruit juice) that increase statin effect






35. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients






36. Drugs available in combination with metformin






37. Inducers of Cytochrome P450 (CYP450)






38. Fluoride released by metabolism of this inhaled anesthetic may cause renal insufficiency






39. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism






40. SE of HMG COA reductase inhibitors






41. HMG CoA reductase inhibitors are contraindicated in






42. These LA's have surface activity






43. Prostaglandins that cause abortions






44. Diuretic used to treat primary aldosteronism






45. Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release






46. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation






47. Drugs of choice for absence seizures






48. Contraindications to use of atropine






49. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia






50. Major effect of benzodiazepines on sleep at high doses