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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Opioid used in the management of withdrawal states
Methadone
Mechlorethamine
Arginine
None
2. Route of administration of warfarin
Ipratropium
Oral
Fluphenazine and haloperidol
Vitamin B12
3. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Metronidazole
Clonazepam
sodium polystyrene sulfonate (Kayexalate)
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
4. Used for SIADH
Demeclocycline
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Pregnancy
Bradykinin and histamine
5. 5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease
Pyridostigmine
Radioactive iodine
Dolasetron
Paclitaxel (taxol)
6. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)
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7. This may antagonize activity of local anesthetics
Hypercalcemia
Ultralente (humulin U)
Vasodilation
ED50
8. This may enhance activity of local anesthetics
Hyperkalemia
hydroxyzine (Atarax)
Disulfiram - like reaction
Vasodilation
9. A hormone whose MOA utilizes transmembrane receptors
Caffeine
Atracurium
Diazepam
Insulin
10. These agents are used as antitussive
Ipodate
Labetalol and carvedilol
Succinylcholine
Dextromethorphan - Codeine
11. 5HT-3 antagonist used in chemotherapeutic induced emesis
Amphetamines
Glyburide - glipizide - and rosiglitazone
Ondansetron - granisetron - dolasetron and alosetron
Protease inhibitors
12. Alkylating agent - vesicant that causes tissue damage with extravasation
Flunitrazepam (rohypnol)
Mechlorethamine
Salmeterol
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
13. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction
Magnesium sulfate
Rheumatic disease
Neostigmine
Pilocarpine - carbachol - physostigmine
14. Almost all local anesthetics have this property and sometimes require the administration of vasoconstrictors (ex. Epinephrine) to prolong activity
Vasodilation
REM is decreased
Oral and transdermal forms of nitroglycerin
Increased thromboembolic events
15. Anti - psychotic not shown to cause tardive dyskinesia
Serotonin syndrome
Clonidine - and methyldopa
Aplastic anemia and acute hepatic failure
Clozapine
16. 1st generation antihistamine that is highly sedating
Diphendydramine
Labetalol and carvedilol
Tizanidine
Tertiary amines
17. Meglitinide class of drugs
Cimetidine
Repaglinide
Thrombocytopenic purpura - and CINCHONISM
Acarbose - miglitol
18. Plasma concentration of a drug at a given time
Magnesium sulfate
Cp
Ketamine
Tetracycline
19. Antibiotic causing red - man syndrome - and prevention
Buspirone
IV administration
Vancomycin - infusion at a slow rate and antihistamines
Erythropoietin
20. Important in synthesis of glucose to glycogen in the liver
Gynecomastia hyperkalemia - and impotence
Anterograde amnesia
GLUT 2
Clonidine - and methyldopa
21. Radio contrast media that inhibits the conversion of T4 to T3
Ipodate
Ethinyl estradiol and mestranol
GFR
Xanthine oxidase
22. SE of salicylates
Tinnitus - GI bleeding
Acute intermittent porphyria
Rescue therapy
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
23. Anti - progesterone used as abortifacient
Prilocaine
Opioid Analgesics
Carboplatin
Mifepristone (RU-486)
24. Agents having higher sedation and antimuscarinic effects than other TCA's
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Bile acid - binding resins
Tertiary amines
Timolol (nonselective) - betaxolol (selective)
25. Chelating agent used in Wilson's disease
Atrial fibrillation and CHF
ACE inhibitors
Kidneys
Penicillamine
26. DOC for influenza A
Aplastic anemia and renal toxicity
Amantadine
Ketoconazole
Aldehyde dehydrogenase
27. Drug used in Chagas disease
Sermorelin
Insulin
Nifurtimox
Amantadine
28. Technique used to diagnose perianal itching - and the drug used to treat it
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Classic
Hydration and mercaptoethanesulfonate (MESNA)
Scotch tape technique and mebendazole
29. Used intranasally and decreases bone resorption
Physostigmine
Esmolol
Calcitonin (salmon prep)
Dapsone - rifampin and clofazimine combination
30. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Morphine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Beta1 agonists
PCP
31. Topical DOC in impetigo
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Bleeding
Topical mupirocin (Bactroban)
Inhibit Na+/Cl - cotransport
32. HIV med used to reduce transmission during birth
Somatostatin
Magnesium sulfate
AZT (zidovudine)
sulfamethoxazole/ trimethoprim
33. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
Oxybutynin - dicyclomine
Cardiac anomalies and is contraindicated in pregnancy or lactation
Phase I
Succinylcholine
34. Occurs when sedative hypnotics are used chronically or at high doses
Fluoxetine (Sarafem)
Tolerance
Dopamine blockade
Esmolol
35. DOC for Legionnaires' disease
Heparin
Tinnitus - GI bleeding
Cyanocobalamin (Vit B12)
Erythromycin
36. Aminoglycosides used with loop diuretics potentiate adverse effect
Ototoxicity
Aldehyde dehydrogenase
pregnancy and with K+
Dipyridamole
37. Ergot alkaloid that is a partial agonist at D2 receptors in the brain - used for patients who are refractory or cannot tolerate levodopa - causes erythromelalgia
Bromocriptine
Uterine contractions
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Bradykinin and histamine
38. Common SE of tamoxifen and raloxifene
Digibind
Diphenhydramine and cimetridine - respectively
Propranolol
Hot flashes
39. SE seen only in men with administration of ketoconazole
Gynecomastia
Aplastic anemia and acute hepatic failure
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Tinnitus - GI bleeding
40. Rapid acting - crystalline zinc insulin used to reverse acute hyperglycemia
NSAIDS
Regular (Humulin R)
Propranolol
Long acting cholinesterase inhibitors
41. Inhaled anesthetic with a low blood/gas partition coefficient
Muscarinic blockers
Nitrous oxide
Metformin
Phenytoin
42. DOC for bipolar affective disorder
Labetalol and carvedilol
Fexofenadine - loratadine - and cetirizine
Selective inhibitor of microtubule assembly
Lithium
43. Agent used in shock because it dilates coronary arteries and increases renal blood flow
Dopamine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Flumazenil
Ferrous sulfate
44. DOC for RSV
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Ribavirin
Methadone
45. Local anesthetic with vasoconstrictive property - favored for head - neck - and pharyngeal surgery
Thiopental
Zafirlukast and montelukast
Phenoxybenzamine
Cocaine
46. MOA of drug or foods (grapefruit juice) that increase statin effect
Finasteride (Proscar and Propecia respectively)
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Sermorelin
Inhibit Cytochrome P450 3A4
47. ABVD regimen used for HD - but appears less likely to cause sterility and secondary malignancies than MOPP
C- peptide
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Esmolol
Work at early distal convoluted tubule
48. SE of nesiritide
Dextromethorphan - Codeine
Excessive hypotension and kidney failure
High therapeutic index
Thioridazine
49. Strong opioid agonists
Salmeterol
Caffeine
Naloxone
Morphine - methadone - meperidine - and fentanyl
50. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep
Amphetamines
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Doxepin