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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug causes teeth discoloration
Tetracycline
Dobutamine and dopamine
B- blockers
Aspirin - Nitrates - CCB - and Beta blockers
2. Anti - seizure agent that induces formation of liver drug - metabolism enzymes - is teratogen and can cause craniofacial anomalies and spina bifida
Albuterol
Haloperidol
Quetiapine
Carbamazepine
3. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
Oral
Amitriptyline
Hyperuricemia - hypokalemia and ototoxicity
Gingival hyperplasia - nystagmus - diplopia and ataxia
4. Antidote to reverse actions of heparin
Dobutamine and dopamine
Protamine sulfate
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
5. Antidote for digoxin toxicity
Hot flashes
GLUT 2
Digibind
Midodrine
6. Interaction with this drug requires dose reduction of 6- MP
Allopurinol
Older antipsychotic agents - D2 receptors
Acebutolol and atenolol
Primaquine
7. Activation of these receptors open K+ ion channels to cause membrane hyperpolarization
Serotonin syndrome
Postsynaptic Mu receptors
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Bleeding
8. Similar to clonidine and may cause hypotension
Tizanidine
Desflurane
Selegiline
Phenoxybenzamine
9. Effective in preventing TIA's
Meperidine
Leuprolide
Clopidogrel and ticlopidine
Acarbose
10. Median effective dose required for an effect in 50% of the population
Retinal destruction and dermatitis
Atropine - pralidoxime (2- PAM)
Primaquine
ED50
11. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
Amrinone and milrinone
Phentolamine
Digoxin
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
12. Toxic effect of anticancer drug can be lessened by rescue agents
Erythropoietin
Rescue therapy
Liver toxicity - increased serum cholesterol
Little C- peptide
13. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors
Cimetidine
PCP
Octreotide
Leuprolide
14. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep
Diphendydramine
Methotrexate
Doxepin
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
15. Tubocurarine is the prototype - pancuronium - atracurium - vecuronium are newer short acting agent - produce competitive block at end plate nicotinic receptor - causing flaccid paralysis
Cartilage damage
Hydration and mercaptoethanesulfonate (MESNA)
Nondepolarizing Neuromuscular Blockers
Succinylcholine
16. Except for these agents all SSRI have significant inhibition of CytP450 enzymes
Protamine
Cortisone and hydrocortisone (equivalent to cortisol)
Chlorpropamide - tolbutamide - tolazamide - etc.
Citalopram and its metabolite escitalopram
17. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Halothane and methoxyflurane
Nitrites
ACE inhibitors
Pyridostigmine
18. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension
Positive Comb's test - depression
Propofol
Irreversibly blocking cyclooxygenase
Hydration and mercaptoethanesulfonate (MESNA)
19. MOA of nesiritide
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Increasing sodium excretion and decreases arterial and venous tone
Bile acid - binding resins
Cartilage damage
20. Important in synthesis of glucose to glycogen in the liver
Meperidine
GLUT 2
Acyclovir; incorporated into viral DNA and chain termination
LSD
21. Beta blockers work in CHF by
Reducing progression of heart failure (never use in acute heart failure)
Desmopressin (DDAVP)
Adenosine
Ethanol
22. MOA of Bisphosphonates
Iron deiodinates thyroxine
Inhibits osteoclast bone resorption
CNS depressants
Bupropion
23. Drug used in cancer therapy causes Cushing - like symptoms
Dopamine
Succinylcholine
Erythromycin
Prednisone
24. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia
Atenolol - acebutolol - and metoprolol
Amphetamines
Phenylephrine
Sumatriptan - naratriptan - and rizatriptan
25. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
Salmeterol
Epinephrine
Chloramphenicol
Bradykinin and histamine
26. Prostaglandin used in the treatment of impotence
Fluoxetine (Sarafem)
Alprostadil
Nicotine
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
27. Benzodiazepines used to promote sleep
Pregnancy
Norepinephrine and serotonin
Temazpam - trizolam - flurazepam
Hyperkalemia
28. Window between therapeutic effect and toxic effect
Beta blockers
None
Therapeutic index
Paclitaxel (taxol)
29. Side effects seen with tricyclic antidepressants
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
NSAIDS
Gingival hyperplasia
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
30. Concurrent use of fibrates and statins increases risk of
Rhabdomyolysis
Clopidogrel and ticlopidine
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Carbenicillin - piperacillin and ticarcillin
31. Inversely related to potency of anesthetics
Valproic acid - carbamazepine - phenytoin and gabapentin
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Minimum alveolar anesthetic concentration (MAC)
Disulfiram
32. Antipsychotics that reduce positive symptoms only
Tissue plasmin activator
Low - potency typical antipsychotics and clozapine
Tetracaine and bupivacaine
Older antipsychotics
33. The most important sign of withdrawal syndrome
Excessive CNS stimulation (seizures)
Ketanserin cyproheptadine - and phenoxybenzamine
Hepatic
CNS toxicity
34. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration
Amphetamines
Dopamine blockade
Nitrous oxide
Reducing preload
35. Treatment of atropine overdose and glaucoma (because lipid soluable). Enters the CNS rapidly and has a stimulant effect - which may lead to convulsions
Cyproheptadine
Epinephrine
Phenobarbital
Physostigmine
36. Drug is used with testosterone for male fertility
Leuprolide
Glyburide - glipizide - and rosiglitazone
Propofol
Red urine discoloration
37. SE for ticlopidine
Hydroxychloroquine
Ethanol
Neutropenia and agranulocytosis
Ketoralac
38. Drug of choice for leprosy
Dapsone - rifampin and clofazimine combination
prolongs QT and PR interval
Low potency phenothiazines and ziprasidone
6- mercaptopurine (6- MP)
39. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation
GLUT 4
Liver toxicity - increased serum cholesterol
Glucagon
Repaglinide
40. Antidote used for acetaminophen (APAP) toxicity
Spironolactone
Ethanol - fomepizole
Dapsone - rifampin and clofazimine combination
N- acetylcysteine (Mucomyst)
41. SE of phenytoin
LSD
Tertiary amines
Gingival hyperplasia - nystagmus - diplopia and ataxia
Trazodone
42. Class of drugs with ability to decrease the maximal response to an agonist
Dicyclomine - methscopolamine
Noncompetitive antagonist
'On - off - phenomenon'
Spironolactone
43. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Demeclocycline
Methicillin - nafcillin - and dicloxacillin
Methimazole and propylthiouracil (PTU)
Buprenorphine
44. Drug causing depletion of substance P (vasodilator)
Cholinesterase inhibitors
Irreversibly blocking cyclooxygenase
Capsaicin
Severe hypertension
45. Used especially in postmenopausal women - dosage should be 1500 mg
Rhabdomyolysis
Neostigmine
Calcium
Nephro and ototoxicity
46. Agent that is teratogen and causes a fetal syndrome
Aspirin - Nitrates - CCB - and Beta blockers
Yohimbine
Ethanol
Lupus - like syndrome
47. SE of heparin
Minocycline
ACE inhibitors
Heparin induced thrombocytopenia (HIT)
Calcium
48. Barbiturate used for the induction of anesthesia
Dopamine
CNS toxicity
Phenytoin
Thiopental
49. Nonselective alpha agonists that increases outflow - probably via the uveoscleral veins
Midazolam
Epinephrine - dipivefrin
Increase the DURATION of GABA- mediated chloride ion channels
Cartilage damage
50. 5HT-3 antagonist used in chemotherapeutic induced emesis
Iron deiodinates thyroxine
Amoxicillin
PGI2 (epoprostenol)
Ondansetron - granisetron - dolasetron and alosetron