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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Examples of alpha - glucosidase inhibitors (AGI)
Methotrexate
Potential for development of Reye's syndrome
CNS stimulation; GI upset
Acarbose - miglitol
2. Pneumonic for beta receptors
NSAIDS
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Imipramine
Dipyridamole
3. Losartan and valsartan block
Angiotensin receptor
Clindamycin
Decreased micro and macro vascular disease
Insulin glargine
4. Antiarrhythmic that exhibits Class II and III properties
Bleeding
Sotalol
Minoxidil
Halothane
5. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention
Enflurane and halothane
Bethanechol
Bile acid - binding resins
Amantadine
6. Antidote used for anticholinergic poisoning
Physostigmine
Ability to cross the placenta
Minocycline
Phase I
7. Concurrent use of fibrates and statins increases risk of
Peripheral neuritis and hepatitis
Rhabdomyolysis
Ethosuximide and valproic acid
Midazolam
8. MOA of sulfonamides
Inhibit dihydropteroate synthase
Spironolactone
Block voltage - dependent sodium channels
Hepatic enzymes
9. Enzyme that metabolizes acetaldehyde to acetate
Aldehyde dehydrogenase
Timolol (nonselective) - betaxolol (selective)
Mifepristone
Zafirlukast and montelukast
10. Antiglaucoma organophosphate
Tetracycline
Valproic acid - carbamazepine - phenytoin and gabapentin
Echothiophate
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
11. Increased risk of developing cataracts
Quetiapine
2 to 3 weeks
Propoxyphene
Muscarinic blockers
12. Prevention of cyclophosphamide induced hemorrhagic cystitis
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Hydration and mercaptoethanesulfonate (MESNA)
Nortriptyline - Desipramine
Potential for development of Reye's syndrome
13. Diuretic used to treat primary aldosteronism
Alprazolam and Clonazepam
Liver toxicity
Spironolactone
Tricyclic antidepressants (TCA)
14. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Acetazolamide
Radioactive iodine
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Mechlorethamine
15. Proteins that prevent action of tumor necrosis factor alpha (TNF- alpha)
Atrial fibrillation and CHF
Acetazolamide
Nicotine
Adalimumab - infliximab and etanercept
16. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Cholinesterase regenerators - pralidoxime
Esmolol
Glargine (Lantus) - detemir
First pass effect
17. Approved for use in severe pulmonary HTN
Prolongs QT interval
GABA- related targets
PGI2 (epoprostenol)
Propranolol
18. Interaction with this drug requires dose reduction of 6- MP
Dobutamine
Allopurinol
Alkylating agent
Ribavirin
19. Monitoring parameter to obtain before initiation of STATINS
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20. Major SE of insulin
Venlafaxine
Hypoglycemia
Neutro - leuko and thrombocytopenia
Octreotide
21. Benzodiazepine used adjunctively in anesthesia
Midazolam
Dimenhydrinate - meclizine - and other 1st generation
Naltrexone
Thioridazine
22. Antidote to reverse actions of warfarin
Diclofenac - ketoralac
Nonselective Muscarinic Antagonists
Sodium bicarbonate
Vitamin K or fresh frozen plasma
23. MOA of Bisphosphonates
Inhibits osteoclast bone resorption
Decreased micro and macro vascular disease
Thioamides - iodides - radioactive iodine - and ipodate
Iron deiodinates thyroxine
24. Products of Phase II conjugation
'On - off - phenomenon'
Desmopressin (DDAVP)
Trazodone
Glucuronate - acetic acid - and glutathione sulfate
25. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
Physostigmine
Bromocriptine
Ethanol
Amrinone and milrinone
26. Antidepressant also used for sleep that causes priapism
Ability to cross the placenta
Trazodone
Paclitaxel (taxol)
Caffeine
27. Non - selective Beta - blocker also used for migraine prophylaxis
Gastric ulcers and GI Bleeding
Propranolol
Urinary acidification and activated charcoal or continual nasogastric suction
Naloxone
28. Opioid that can be given PO - by epidural - and IV - which helps to relieve the dyspnea of pulmonary edema
Dry cough - hyperkalemia
DOM - STP - MDA - and MDMA 'ecstasy'
Naloxone (IV) - naltrexone (PO)
Morphine
29. Treatment of resistant pseudomembranous colitis
Iodide salts
ORAL vancomycin
Administration of Vit. B6 (pyridoxine)
Phenytoin
30. SE of both warfarin and heparin
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Beta -1 selective blockers
Bleeding
31. Rapid acting - crystalline zinc insulin used to reverse acute hyperglycemia
Neutropenia and agranulocytosis
Regular (Humulin R)
Diphendydramine
GI bleeding
32. Anemia caused by trimethoprim
Megaloblastic anemia
Acyclovir; incorporated into viral DNA and chain termination
Dextromethorphan - Codeine
Vancomycin - infusion at a slow rate and antihistamines
33. These agents are congeners of Amphetamine
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34. Inversely related to potency of anesthetics
Minimum alveolar anesthetic concentration (MAC)
Ethanol
Inhibit DNA gyrase
Most are thought to act at GABA- A receptor - chloride channel
35. Opioids used in anesthesia
Corticosteroids
Morphine and fentanyl
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Lactic acidosis
36. SE of clonidine
Albuterol
Rebound HTN - sedation - dry mouth
Epinephrine
DOM - STP - MDA - and MDMA 'ecstasy'
37. Carbamate with intermediate action - used for+A1170 postoperative and neurogenic ileus and urinary retention
Neostigmine
Pulse therapy
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Diethylstilbestrol (DES)
38. Beta blockers are used for which type of anginal attack
Classic
Physostigmine
Nitroglycerin sublingual tablets
Pilocarpine - carbachol - physostigmine
39. Anti - malarial drug used in rheumatoid arthritis (RA)
Hydroxychloroquine
Tamsulosin (Flomax)
Temazpam - trizolam - flurazepam
Amantadine
40. Endogenous insulin contains
Thioamides - iodides - radioactive iodine - and ipodate
Normal C- peptide
Somatostatin
Prednisone
41. Common side effect of Rifampin
GI bleeding
Theophylline
Caffeine
Red urine discoloration
42. Ability to produce less than 100% of the response
Partial agonist
Bromocriptine
Topical mupirocin (Bactroban)
Lorazepam - oxazepam - and temazepam
43. THC is active ingredient - SE's include impairment of judgment - and reflexes - decreases in blood pressure and psychomotor performance occur
Marijuana
Echothiophate
GABA- related targets
Insulin secretagogue - closes ATP- sensitive K+ channel
44. Cholestyramine and colestipol are
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Aspirin irreversibly inhibits cyclooxygenase
Bile acid - binding resins
Oral and transdermal forms of nitroglycerin
45. Median effective dose required for an effect in 50% of the population
ED50
Anterograde amnesia
Glyburide - glipizide - and rosiglitazone
pregnancy and with K+
46. PCN active against pseudomonas
Iodide salts
Carbenicillin - piperacillin and ticarcillin
Muscarinic blockers
Nortriptyline - Desipramine
47. NSAID available orally - IM and ophthalmically
Ipratropium
Ketoralac
Penicillamine
Nandrolone - oxymetholone - and oxandrolone
48. 5 alpha - reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness
Disulfiram - like reaction
sulfamethoxazole/ trimethoprim
Finasteride (Proscar and Propecia respectively)
Dopamine
49. Mineralocorticoids
Presynaptic mu - delta - and kappa receptors
Morphine
Fludrocortisone and deoxycorticosterone
Somatrem
50. IV barbiturate used as a pre - op anesthetic
Methotrexate
Phentolamine
Thiopental
Magnesium sulfate