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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA






2. MOA of AGI's






3. MOA of metformin






4. Interferes with activity of T- lymphocytes






5. These agents are congeners of Amphetamine

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6. The fraction of administered dose of a drug that reaches systemic circulation






7. Concentration in the plasma times (clearance divided by bioavailability)






8. Antidote used for warfarin toxicity






9. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea






10. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep






11. H2 blocker that causes the most interactions with other drugs






12. Peptide drug used to treat CHF






13. Most widely used thyroid drugs such as Synthroid and Levoxyl contain






14. Available bisphosphonates






15. Life threatening cardiac event that prolong QT leads to






16. Exogenous insulin contains






17. Beta 1 agonists used in acute CHF






18. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress






19. Vascular effects of metformin






20. SE of acetazolamide






21. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents






22. Most commonly abused in health care professionals






23. Rate limiting step of alcohol metabolism






24. Metronidazole SE if given with alcohol






25. Receptors for serotonin (5HT-1) are located






26. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis






27. The selective agents loose their selectivity at






28. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention






29. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects






30. SE of nitrates






31. Drug causing depletion of substance P (vasodilator)






32. The most frequent cause of acute deaths in cholinesterase inhibitor toxicity






33. SE for Lamotrigine






34. Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates






35. Fibrates (gemfibrozil) increase activity of






36. Well - tolerated and are first - line antidepressants

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37. MOA of both generations






38. Drug used in Chagas disease






39. Inhibitor of leukotrienes (LTD4) receptors and used in asthma






40. MOA of erythromycin






41. Beta blockers partial agonist activity (intrinsic sympathomimetic activity) cause some bronchodilation and may have an advantage in treating patients with asthma






42. Important in synthesis of glucose to glycogen in the liver






43. Weak opioid agonist - poor analgesic - its overdose can cause severe toxicity including respiratory depression - circulatory collapse - pulmonary edema - and seizures






44. Most useful in patients with significant anxiety - phobic features - hypochondriasis - and resistant depression






45. Major route of elimination for Lithium






46. Beta blockers work in CHF by






47. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion






48. Treatments available for nicotine addiction






49. Common SE of spironolactone






50. Neurotransmitters affected by the action of antidepressants