Test your basic knowledge |

USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. These agents are used as antitussive






2. Produces disulfiram - like reaction with ethanol






3. Antidepressants with no effect on BP - no sedation






4. Selective alpha agonists that decreases aqueous secretion






5. Potassium sparing diuretics inhibit






6. DOC for status epilepticus






7. Shock due to septicemia or myocardial infarction is made worse by






8. Most dangerous of the currently popular hallucinogenic drugs - OD leads to nystagmus - marked hypertension - and seizures - presence of both horizontal and vertical nystagmus is pathognomonic






9. Newer NSAID that selectively inhibits COX-2






10. Thrombolytic that can cause allergic reaction






11. Pneumonic for 3 zones of adrenal cortex






12. Anti - viral agents associated with Stephen Johnson syndrome






13. Alternative anticoagulant used if HIT develops






14. Metronidazole SE if given with alcohol






15. Toxicity of organophosphate:






16. Anti - seizure drugs used also for Trigeminal neuralgia






17. Antidote used for methanol and ethylene glycol






18. Anti - malarial drug used in rheumatoid arthritis (RA)






19. Important in muscle and adipose tissue for glucose transport across muscles and TG storage by lipoprotein lipase activation






20. Antidote for methotrexate toxicity






21. SE of beta blockers






22. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors






23. Meglitinide class of drugs






24. Names of three bisphosphonates available IV






25. Slightly increased risk of breast cancer - endometrial cancer - heart disease (questionable) - has beneficial effects on bone loss






26. Withdrawal from this drug causes lethargy - irritability - and headache






27. Aminoglycosides used with loop diuretics potentiate adverse effect






28. Phenylisopropylamines that are used legitimately and abused for narcolepsy - attention deficit disorder - and weight reduction






29. Strength of interaction between drug and its receptor






30. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis






31. Bleomycin+vinblastine+etoposide+cisplatin produce almost a 100% response when all agents are used for this neoplasm






32. MOA of loop diuretics






33. Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release






34. Skeletal muscle agent that undergoes Hofmann elimination (breaks down spontaneously)






35. Concern using lithium






36. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease






37. 5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease






38. '5HT-1d agonist used for migraine headaches '






39. MOA of nateglinide






40. May protect against doxorubicin toxicity by scavenging free radicals






41. 1st generation antihistamine that is least sedating






42. Anti - seizure agent that exhibits non - linear metabolism - highly protein bound - causes fetal hydantoin syndrome - and stimulates hepatic metabolism






43. SE of lithium






44. Drug used in cancer therapy causes Cushing - like symptoms






45. DOC for bipolar affective disorder






46. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation






47. Antidote used for lead poisoning






48. Agent having no effect on D2 receptors - blocks D4 - reserved for resistant schizophrenia - and can cause fatal agranulocytosis






49. MOA of cisplatin






50. Non ergot agents used as first - line therapy in the initial management of Parkinson's