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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. These Beta blockers decrease aqueous secretion
Timolol (nonselective) - betaxolol (selective)
Allopurinol
Topical mupirocin (Bactroban)
IV and IM (only LMW)
2. Used for SIADH
Disulfiram
Demeclocycline
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Ethosuximide and valproic acid
3. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Interleukin 11 (oprelvekin)
Zileuton
Rebound HTN - sedation - dry mouth
Hyperuricemia - hypokalemia and hyperglycemia
4. Treatment of motion sickness
Adenosine
Scopolamine - meclizine
Clomipramine - fluoxetine and fluvoxamine
Nitrous oxide
5. Drugs of choice for generalized tonic - clonic and partial seizures
Benztropine - trihexyphenidyl
Combination oral contraceptives (OC)
Valproic acid and Phenytoin
Delavirdine - efavirenz - and ribavirin
6. New class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins
Ezetimibe (Zetia)
NSAIDS
Somatrem
Loading dose (Cp*(Vd/F))
7. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively
Ferrous sulfate
Leuprolide
Arteries and veins
Pralidoxime
8. Antidepressants with no effect on BP - no sedation
SSRIs
Pramipexole and ropinirole
Ketanserin cyproheptadine - and phenoxybenzamine
Fluoxetine (Sarafem)
9. Irreversible condition resulting from the use of antipsychotics - reserpine at high doses - and MPTP (by- product of illicit meperidine analog)
Drug induced Parkinsonism
Epinephrine - dipivefrin
Aminoglutethimide
Chlordiazepoxide and Diazepam
10. 'Date rape drug'
Flunitrazepam (rohypnol)
Bioavailability (F)
5- flouracil (5- FU)
Dextroamphetamines and methamphetamine
11. Technique used to diagnose perianal itching - and the drug used to treat it
Nephro and ototoxicity
Thyroid and steroid hormones
Scotch tape technique and mebendazole
Acebutolol and atenolol
12. Methyldopa is contraindicated in
Thick ascending limb
Geriatrics due to its CNS (depression) effects
Ezetimibe (Zetia)
Low potency phenothiazines and ziprasidone
13. Major nutritional side effect of bile acid - binding resins
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Dobutamine
Phenytoin
14. Antidote used for anticholinergic poisoning
REM is decreased
Hepatic enzymes
Prilocaine
Physostigmine
15. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Zafirlukast and montelukast
Buprenorphine
Liver enzyme INDUCTION
16. Anti - progesterone used as abortifacient
Nitroprusside
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Aspirin
Mifepristone (RU-486)
17. Antidote used for iron salt toxicity
Fexofenadine - loratadine - and cetirizine
Heparin induced thrombocytopenia (HIT)
LD50
Deferoxamine
18. SE for ganciclovir
Hepatic
Thick ascending limb
Raloxifene (SERM- selective estrogen receptor modulator)
Neutro - leuko and thrombocytopenia
19. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation
Hepatotoxicity
Aspirin
Fluorocarbons and Industrial solvents
Heparin
20. Agents that reduce heart rate - contractility - and O2 demand
pregnancy and with K+
Beta - blockers
Halothane and methoxyflurane
Adalimumab - infliximab and etanercept
21. Chelating agent used in acute iron toxicity
Heroin - morphine - oxycodone - meperidine and fentanyl
Deferoxamine
Zileuton
Leuprolide
22. This beta blocker is the longest acting
Hypertrichosis
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Aspirin
Nadolol
23. Osmotic diuretic used to treat increased intracranial pressure
Cholinesterase regenerators - pralidoxime
Cisplatin
Ketoralac
Mannitol
24. Beta 1 agonists used in acute CHF
Haloperidol
Log - kill hypothesis
Little C- peptide
Dobutamine and dopamine
25. Available bisphosphonates
Mechlorethamine
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Methadone - followed by slow dose reduction
block SLUD (salivation - lacrimation - urination - defecation
26. Inhaled anesthetics are myocardial depressants
Enflurane and halothane
Gastric ulcers and GI Bleeding
Reduce inhibition - suppress anxiety - and produce relaxation
Clomipramine - fluoxetine and fluvoxamine
27. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
Lupus - like syndrome
Sinus tachycardia and serious arrhythmias
Buspirone
Haloperidol
28. Short acting glucocorticoids
Cortisone and hydrocortisone (equivalent to cortisol)
Aldehyde dehydrogenase
Glucagon
Spironolactone
29. Median effective dose required for an effect in 50% of the population
Flutamide (Eulexin)
Infants - closed angle glaucoma - prostatic hypertrophy
Heparin induced thrombocytopenia (HIT)
ED50
30. MOA of loop diuretics
Venlafaxine
inhibits Na+/K+/2Cl - cotransport
Morphine
Reducing preload
31. Treatment of myasthenia gravis
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Oral and transdermal forms of nitroglycerin
Angiotensin receptor
Pyridostigmine
32. Drug elimination with a constant amount metabolized regardless of drug concentration
Magnesium sulfate
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Insulin secretagogue - closes ATP- sensitive K+ channel
Zero order kinetics
33. Antiarrhythmic effective in most types of arrhythmia
Amiodarone
Lupus - like syndrome
Hydroxychloroquine
L- thyroxine (T4)
34. These beta blockers are less lipid soluble
Clonidine - and methyldopa
Bile acid - binding resins
Acebutolol and atenolol
NSAIDS
35. Life threatening cardiac event that prolong QT leads to
Torsades de pointes
Loading dose (Cp*(Vd/F))
Bromocriptine
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
36. Antidote useful for some drug induced Torsade de pointes
Amantadine
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Ipratropium
Magnesium sulfate
37. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism
Aztreonam
Iodide salts
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Celecoxib
38. Class III antiarrhythmic that exhibits properties of all 4 classes
Amiodarone
Anterograde amnesia
Patches - gum - nasal spray - psychotherapy - and bupropion
Pyridostigmine
39. Drug of choice for myoclonic seizures
PGI2 (epoprostenol)
Nesiritide (BNP)
Valproic acid
Acute intermittent porphyria
40. Some side effects of corticosteroids
Opioid Analgesics
Celecoxib
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Nifedipine
41. Thiazolidinediones
Affinity
L- asparaginase
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Nesiritide (BNP)
42. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Ethanol
Phenytoin
Neutropenia and agranulocytosis
Dimercaprol - EDTA
43. Anti - emetics used in association with anti - cancer drugs that are 5- HT3 (serotonin receptor subtype ) antagonists
Amrinone and milrinone
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Odansetron - granisetron
44. This agent may cause more severe - rapid and intense symptoms to a recovering addict
Timolol
Naloxone
Methadone - followed by slow dose reduction
Sulfonamides
45. Sedative - Hypnotics action
Inhibition of protein synthesis at the 50s subunit of ribosome
GI bleeding
Calcitonin (salmon prep)
Reduce inhibition - suppress anxiety - and produce relaxation
46. Benzodiazepines that are the most effective in the treatment of panic disorder
Acute intermittent porphyria
Alprazolam and Clonazepam
Salmeterol
Tricyclic antidepressants (TCA)
47. Beta 2 agonist toxicity
Skeletal muscle tremor - tachycardia
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Nicotine
Reducing preload
48. Triptan available in parenteral and nasal formulation
Ceftriaxone
ORAL vancomycin
Sumatriptan
Oxidation - reduction - hydrolysis
49. SE of tPA
Cerebral hemorrhage
Quetiapine
Meperidine
Valproic acid
50. MOA action of cromolyn
Mast cell stabilizer
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
CNS toxicity
Levodopa