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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antidote used for cyanide poisoning
Finasteride (Proscar and Propecia respectively)
Nitrites
Cyclobenzaprine
Neuroleptanesthesia
2. SE of mirtazapine
Liver toxicity - increased serum cholesterol
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Alprazolam
Digoxin
3. Anemia caused by trimethoprim
Megaloblastic anemia
Epinephrine
Calcium channel blockers
Clindamycin
4. SE of imipenem
Seizures
IV and IM (only LMW)
Zero order kinetics
L- thyroxine (T4)
5. These agents are used as antidiarrheal
Hepatic toxicity
Zolpidem
Flunitrazepam (rohypnol)
Diphenoxylate - Loperamide
6. Most common SE of fibrates
Infants - closed angle glaucoma - prostatic hypertrophy
N- acetylcysteine (Mucomyst)
Amiodarone
Nausea
7. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Valproic acid
Buspirone
Gabapentin
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
8. Antiprogestin used as potent antagonist of GC receptor
Affect calcium - potassium - and sodium channels
Degradation of fibrin clots and are administered IV
Flutamide (Eulexin)
Mifepristone
9. SE seen only in men with administration of ketoconazole
Glucagon
First pass effect
Gynecomastia
Low therapeutic index
10. Antivirals that are teratogens
Beta blockers
Buspirone
Delavirdine - efavirenz - and ribavirin
Hyperuricemia - hypokalemia and hyperglycemia
11. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Vancomycin - infusion at a slow rate and antihistamines
Repaglinide
Calcium channels
Ethanol
12. SE of colchicine
2 to 3 weeks
Phenytoin
Methotrexate
Kidney and liver toxicity - diarrhea
13. Digoxin toxicity can be precipitated by
Hyperuricemia - hypokalemia and ototoxicity
Hypokalemia
Lactic acidosis
Methotrexate
14. SE of Thiazolindinediones
Sodium channel blockade
Calcitonin (salmon prep)
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Lorazepam - oxazepam - and temazepam
15. Some of SSRIs' therapeutic effects beside depression
Tolerance
Decrease arterial blood pressure
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Fentanyl
16. Drug ofter used in combination with TNF - alpha inhitors for RA
Methoxyflurane
Flunitrazepam (rohypnol)
Arginine
Methotrexate
17. Used for Cushing's syndrome (increased corticosteroid)
Dolasetron
Atropine - pralidoxime (2- PAM)
Dexamethasone suppression test
Physostigmine
18. Beta blockers are used for which type of anginal attack
Salmeterol
Classic
Hepatotoxicity
Calcium
19. Long acting beta 2 agonist used in asthma
Chlorpropamide
Erythropoietin
Salmeterol
Urinary acidification and activated charcoal or continual nasogastric suction
20. Some cell cycle non - specific drugs
Log - kill hypothesis
Mechlorethamine
Sinus tachycardia and serious arrhythmias
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
21. Beta blockers partial agonist activity (intrinsic sympathomimetic activity) cause some bronchodilation and may have an advantage in treating patients with asthma
CNS toxicity
Mannitol
Ethanol
Pindolol and acebutolol
22. Adenosine's MOA
block SLUD (salivation - lacrimation - urination - defecation
GABA- related targets
Tamsulosin (Flomax)
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
23. SE of long term (>5 days) corticosteroid therapy and remedy
2 to 3 weeks
Adrenal suppression and weaning slowly - respectively
lispro insulin - aspart insulin - glulisine insulin
Increasing afterload and tissue perfusion declines
24. Exogenous insulin contains
Little C- peptide
Therapeutic index
Warfarin (PT)
Liver enzyme INDUCTION
25. This beta blocker is highly lipid soluble and may account for side effects such as nightmares
Ethinyl estradiol and mestranol
Propranolol
Lupus - like syndrome
Patches - gum - nasal spray - psychotherapy - and bupropion
26. These prevent the action of Ach at the skeletal muscle endplate to produce a 'surmountable blockade -' effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)
Dopamine
Nondepolarizing type antagonists
Xanthine oxidase
Nicotine
27. Peptide causing increased capillary permeability and edema
Ethanol - Barbiturates - and Benzodiazepines
Carvedilol
Bradykinin and histamine
Temazpam - trizolam - flurazepam
28. Leads to respiratory depression progressing to coma and death
Retinal destruction and dermatitis
Overdose of opioids
Infants - closed angle glaucoma - prostatic hypertrophy
Fluoxetine
29. Benzodiazepines that are the most effective in the treatment of panic disorder
Neuroleptanesthesia
Beta blockers
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Alprazolam and Clonazepam
30. Ability of a drug to produce 100% of the maximum response regardless of the potency
Full agonist
Stimulates cGMP which leads to vascular smooth muscle relaxation
Half - life (T1/2)
Carbamazepine
31. Benzodiazepine that is used for anesthesia
Midazolam
Suramin
Methotrexate
Minocycline
32. Maximum response achieveable from a drug
Fluoxetine
Propoxyphene
Efficacy
Digibind
33. Toxic effect of anticancer drug can be lessened by rescue agents
Amoxicillin
Meperidine
Rescue therapy
Chlordiazepoxide and Diazepam
34. SE of clonidine
Acebutolol - atenolol - esmolol - metoprolol
Finasteride (Proscar and Propecia respectively)
Rebound HTN - sedation - dry mouth
Flumazenil
35. T3 compound less widely used
Cytomel
Skeletal muscle tremor - tachycardia
Pralidoxime
Disulfiram - like reaction
36. DOC for Legionnaires' disease
L- dopa
Prostaglandin PGF2a
Erythromycin
Nephro and ototoxicity
37. Drug of choice for generalized anxiety disorder - Not effective in acute anxiety
Buspirone
Sodium bicarbonate
N- acetylcysteine (Mucomyst)
Thrombocytopenic purpura - and CINCHONISM
38. W/D from this drug causes anxiety and mental discomfort
Benztropine
Disulfiram
Nicotine
Ondansetron - granisetron - dolasetron and alosetron
39. Agent to treat torsades de pointes
Magnesium sulfate
Odansetron - granisetron
L- asparaginase
CNS depressants
40. Lactam that can be used in PCN allergic patients
Levodopa
Methotrexate
Aztreonam
Physostigmine
41. Antidote for arsenic - mercury - lead - and gold poisoning
Dimercaprol
Mast cell stabilizer
Diethylstilbestrol (DES)
Lispro (Humalog) - aspart - glulisine
42. Side effect of sotalol
Desflurane
Tricyclic antidepressants (TCA)
prolongs QT and PR interval
Morphine and fentanyl
43. The elimination of drug that occurs before it reaches the systemic circulation
Irreversibly blocking cyclooxygenase
Fludrocortisone and deoxycorticosterone
First pass effect
Nateglinide
44. Uses of bisphosphonates
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45. Pyrimidine analog that causes 'Thymine - less death' given with leucovorin rescue
Oral
Doxepin
Nitrous oxide
5- flouracil (5- FU)
46. Fibrates (gemfibrozil) increase activity of
Buspirone
Ganciclovir - zidovudine - saquinavir - and interferon
Bile acid - binding resins
Lipoprotein lipase
47. Nitrate used to prevent further attacks
Rifampin
Succinylcholine
Oral and transdermal forms of nitroglycerin
Diphendydramine
48. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Diazepam
Odansetron
Urinary acidification and activated charcoal or continual nasogastric suction
Timolol
49. Usual time needed for full effect of antidepressant therapy
Chloramphenicol
Dapsone - rifampin and clofazimine combination
Fexofenadine - loratadine - and cetirizine
2 to 3 weeks
50. Ability to produce less than 100% of the response
Partial agonist
Bradykinin
Ketoralac
Ortho - Evra