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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Major SE of zileuton
Neuroleptanesthesia
Fluphenazine and haloperidol
GFR
Liver toxicity
2. Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons
Aspirin
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Ascending pathways
Abstinence syndrome
3. Rapid acting - crystalline zinc insulin used to reverse acute hyperglycemia
Regular (Humulin R)
Peripheral neuritis and hepatitis
Low therapeutic index
Antithrombin 3
4. Major SE of bisphosphonates
Aspirin
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Cosyntropin
Chemical esophagitis
5. Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)
Ethanol
Pralidoxime
Muscarinic blockers
Magnesium sulfate
6. This parenteral beta blocker is a short acting (minutes)
Carbamazepine
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Pralidoxime - atropine
Esmolol
7. Antidote used for carbon monoxide poisoning
Acyclovir; incorporated into viral DNA and chain termination
Valproic acid
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
100% O2 and hyperbaric O2
8. Drugs of choice for status epilepticus
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Ferrous sulfate
Carbamazepine
Chloramphenicol
9. B- blockers that are more cardioselective
Neutro - leuko and thrombocytopenia
Nifurtimox
Atropine - homatropine - C1208 tropicamide
Beta -1 selective blockers
10. Selectivity of a drug for its receptor
Dolasetron
Specificity
Tetracaine and bupivacaine
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
11. LA causing methemoglobinemia
Lipoprotein lipase
Lactic acidosis
Neutro - leuko and thrombocytopenia
Prilocaine
12. Drug used for N. gonorrhea in females
Raloxifene (SERM- selective estrogen receptor modulator)
Infants
Bioavailability (F)
Ceftriaxone
13. Drugs decrease intestinal absorption of cholesterol
Chloramphenicol
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Streptokinase
Bile acid - binding resins
14. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep
Oxybutynin - dicyclomine
Pilocarpine
Doxepin
Raloxifene
15. MOA of Leflunomide (newer agent)
prolongs QT and PR interval
Somatostatin
Raloxifene
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
16. NSAID available orally - IM and ophthalmically
Protamine
Most are thought to act at GABA- A receptor - chloride channel
Ketoralac
Carbamazepine - gabapentin - lamotrigine - and valproic acid
17. Anti - biotic frequently used for chronic UTI prophylaxis
Topical mupirocin (Bactroban)
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Carboplatin
sulfamethoxazole/ trimethoprim
18. Antivirals associated with neutropenia
Efficacy
Hypertensive crisis
Beta blockers
Ganciclovir - zidovudine - saquinavir - and interferon
19. Type of kinetics when a constant percentage of substrate is metabolized per unit time
Diazepam
CNS toxicity
First order kinetics
Desmopressin (DDAVP)
20. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia
Phenylephrine
hydroxyzine (Atarax)
Muscarinic blockers
Bradykinin
21. Non - benzodiazepine used for sleep
ACE inhibitors
Morphine
Zolpidem
Acebutolol - atenolol - esmolol - metoprolol
22. Digoxin is used in
Cyclophosphamide
Verapamil
Midodrine
Atrial fibrillation and CHF
23. Nonselective alpha - blocking drug - short acting and reversible - used for rebound HTN from rapid clonidine withdrawal - and Raynaud's phenomena
Metronidazole
AZT (zidovudine)
Phentolamine
inhibits Na+/K+/2Cl - cotransport
24. This is the drug of choice for anaphylactic shock
Esmolol
Bromocriptine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Epinephrine
25. Prevention of cyclophosphamide induced hemorrhagic cystitis
Dexrazoxane
Hydration and mercaptoethanesulfonate (MESNA)
Dobutamine
Lepirudin
26. CCB with predominate effect on arteriole dilation
AZT (zidovudine)
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Hepatic enzymes
Nifedipine
27. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
Severe hypertension
Probenecid and sulfinpyrazone
Calcium channels
Mannitol
28. State of analgesia and amnesia produced when fentanyl is used with droperidol and nitrous oxide
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Neuroleptanesthesia
Hallucinations resembling psychosis
Terfenadine and astemizole (have been removed from the market)
29. SE of demeclocycline
Physostigmine
Parathion
Bone marrow and teeth discoloration for children under 8 years of age
Prostaglandin PGF2a
30. DOC for digoxin induced arrhythmias
Sulfonamides
Ferrous sulfate
Phenytoin
Acetazolamide
31. PTU (propylthiouracil) MOA
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Calcium
Amphetamines
Aspirin - Nitrates - CCB - and Beta blockers
32. MOA of lovastatin (STATIN)
inhibits HMG COA reductase
Bile acid - binding resins
Fluoxetine (Sarafem)
Succinylcholine
33. Class of drugs that may cause cross - sensitivity with thiazide diuretics
Erythropoietin
Morphine - methadone - meperidine - and fentanyl
Sulfonamides
Mivacurium
34. Benzodiazepines that are the most effective in the treatment of panic disorder
Cholinesterase inhibitors
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Alprazolam and Clonazepam
Midodrine
35. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Somatrem
DOM - STP - MDA - and MDMA 'ecstasy'
pregnancy and with K+
Ketamine
36. Reason fluoroquinolones are contraindicated in children and pregnancy
Decreased micro and macro vascular disease
Cartilage damage
Therapeutic index
Competitive antagonist
37. Barbiturates may precipitate this hematologic condition
Carmustine (BCNU) and lomustine (CCNU)
Acute intermittent porphyria
Desmopressin (DDAVP)
Disulfiram - like reaction
38. Antidote for digoxin toxicity
Capsaicin
Digibind
LFT's
None
39. Inhaled anesthetic causes peripheral vasodilation
Bone marrow and teeth discoloration for children under 8 years of age
Dopamine
Isoflurane
AZT (zidovudine)
40. SSRI less likely to cause a withdrawal syndrome
Cocaine
Heroin - morphine - oxycodone - meperidine and fentanyl
Flumazenil
Fluoxetine
41. Products of Phase II conjugation
Chlorpropamide
Glucuronate - acetic acid - and glutathione sulfate
Valproic acid
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
42. Non - selective Alpha1blockers use to treat pheochromocytoma
Phenoxybenzamine
Disulfiram - like reaction
Sedation
Thick ascending limb
43. DOC to treat chemo - induced nausea and vomiting
Prostaglandin PGF2a
Odansetron
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Succinylcholine
44. Aspirin is contraindicated in children with viral infection
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45. Cephalosporins Not able to cross the BBB
Calcium channel blockers
Cefixime (3rd) generation
Methicillin - nafcillin - and dicloxacillin
Dopamine blockade
46. Antiglaucoma organophosphate
SSRI's - bupropion - and venlafaxine
Cephalosporins
Echothiophate
Atropine - pralidoxime (2- PAM)
47. Produce mydriasis and cycloplegia
Atropine - homatropine - C1208 tropicamide
Somatrem
Tolerance
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
48. Class of antibiotics that have 10% cross sensitivity with penicillins
prolongs QT and PR interval
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Cephalosporins
Warfarin (PT)
49. DOC for status epilepticus
Penicillamine
Pregnancy
Diazepam
Morphine and fentanyl
50. This step of metabolism makes a drug more hydrophilic and hence augments elimination
Labetalol and carvedilol
Steroids
Phase I
Nitrous oxide