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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. MOA of thiazolindinediones






2. Maximum response achieveable from a drug






3. MOA of nitrates






4. Sedation is a common side effect of these drugs - they lower seizure threshold - uses include BAD - acute panic attacks - phobias - enuresis - and chronic pain and their overdose can be deadly






5. SE of nesiritide






6. What do alpha cells in the pancreas produce?






7. Prevents thrombosis in patients with artificial heart valve






8. Constant proportion of cell population killed rather than a constant number






9. Agent used in shock because it dilates coronary arteries and increases renal blood flow






10. This agent cause increased aqueous outflow






11. Side effect of sotalol






12. Orthostatic hypotension and QT prolongation






13. Agents that inhibit acetaldehyde dehydrogenase






14. Cephalosporin causes kernicterus in neonates






15. Antidote used for benzodiazepine toxicity






16. SE of Aspirin






17. Leads to respiratory depression progressing to coma and death






18. Losartan and valsartan block






19. Treatment of choice for organophosphate overdose






20. Strength of interaction between drug and its receptor






21. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN






22. Newer alpha 2 agonist (apraclonidine and brimonidine) treat glaucoma by acting to






23. Digoxin is used in






24. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal






25. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property






26. DOC for febrile seizures






27. Anti - emetics used in association with anti - cancer drugs that are 5- HT3 (serotonin receptor subtype ) antagonists






28. Produce mydriasis and cycloplegia






29. Cystitis - postoperative bladder spasms - or incontinence






30. Endogenous substances commonly interpreted as histamine - serotonin - prostaglandins - and vasoactive peptides






31. Antiarrhythmic effective in most types of arrhythmia






32. Major SE of insulin






33. Opioid antagonist that is given IV and had short DOA






34. Weak opioid agonist - poor analgesic - its overdose can cause severe toxicity including respiratory depression - circulatory collapse - pulmonary edema - and seizures






35. Most frequent route of metabolism






36. Some of SSRIs' therapeutic effects beside depression






37. Slightly increased risk of breast cancer - endometrial cancer - heart disease (questionable) - has beneficial effects on bone loss






38. Pyrimidine analog that causes 'Thymine - less death' given with leucovorin rescue






39. Non - selective Alpha1blockers use to treat pheochromocytoma






40. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents






41. Treatment of resistant pseudomembranous colitis






42. Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs






43. State of analgesia and amnesia produced when fentanyl is used with droperidol and nitrous oxide






44. Side effects occuring in antipsychotics that block dopamine






45. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention






46. These LA's have surface activity






47. Antiestrogen drugs used for fertility and breast cancer respectively






48. Antidepressant associated with seizures and cardiotoxicity






49. Inhaled anesthetic causes peripheral vasodilation






50. Fibrates (gemfibrozil) increase activity of