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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antidote for salicylate intoxication






2. Drugs that can be used for infantile spasms






3. Vitamin K dependent anticoagulant






4. Agents used in Huntington's Disease






5. Loops lose and thiazide diuretics retain






6. Inhibitor of lipoxygenase






7. Agent used for acute muscle spasm






8. GnRH antagonist with more immediate effects - used for infertility






9. Common SE of spironolactone






10. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property






11. Occurs when sedative hypnotics are used chronically or at high doses






12. Major effect of benzodiazepines on sleep at high doses






13. Rate limiting step of alcohol metabolism






14. This parenteral beta blocker is a short acting (minutes)






15. Anti - seizure agent that exhibits non - linear metabolism - highly protein bound - causes fetal hydantoin syndrome - and stimulates hepatic metabolism






16. MOA of colchicine (used in acute gout)






17. Inhaled anesthetics are myocardial depressants






18. COX 2 inhibitors may have reduced risk of






19. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis






20. Regimen used for breast cancer






21. Very rapid acting insulin - having fastest onset and shortest duration of action






22. MOA of tetracycline






23. Prototypical drug is atropine






24. Warfarin is contraindicated in






25. Antifungal agent used for inhibition of all gonadal and adrenal steroids






26. Long acting glucocorticoids






27. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)






28. Antidote used for iron salt toxicity






29. Causes acne - premature closure of epiphyses - masculinization in females - hepatic dysfunction - MI - and increases in libido and aggression






30. Used for Cushing's syndrome (increased corticosteroid)






31. Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine - like side effects






32. Agent used to treat chronic gout by increasing uric acid secretion and excretion






33. CCB contraindicated in CHF






34. Antidepressant associated with neuroleptic malignant syndrome






35. Antipsychotic having the strongest autonomic effects






36. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock






37. Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)






38. Antidote useful for some drug induced Torsade de pointes






39. Digoxin is used in






40. Most dangerous of the currently popular hallucinogenic drugs - OD leads to nystagmus - marked hypertension - and seizures - presence of both horizontal and vertical nystagmus is pathognomonic






41. Leads to respiratory depression progressing to coma and death






42. Contraindications to use of atropine






43. Drug causing depletion of substance P (vasodilator)






44. These prevent the action of Ach at the skeletal muscle endplate to produce a 'surmountable blockade -' effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)






45. MOA of drug or foods (grapefruit juice) that increase statin effect






46. Treatment of motion sickness






47. Pyrimidine analog that causes 'Thymine - less death' given with leucovorin rescue






48. MOA of nystatin






49. Diuretic used to treat primary aldosteronism






50. Antiprogestin used as potent antagonist of GC receptor