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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Generation of antihistamine that has the most CNS effects
First generation due to being more lipid - soluble
Bupropion
Alkylating agent
Cutaneous flush
2. Fibrates (gemfibrozil) increase activity of
Cholinesterase regenerators - pralidoxime
Islets of Langerhans
Lipoprotein lipase
Clozapine
3. Major SE of bisphosphonates
Morphine - methadone - meperidine - and fentanyl
Chemical esophagitis
First order kinetics
Alkylating agent
4. Anti - psychotic not shown to cause tardive dyskinesia
Classic
Nephrotoxicity
Atrial fibrillation and CHF
Clozapine
5. Ergot alkaloid that is a partial agonist at D2 receptors in the brain - used for patients who are refractory or cannot tolerate levodopa - causes erythromelalgia
Dobutamine
Organic nitrites
Toremifene (Fareston)
Bromocriptine
6. 'Date rape drug'
Neutropenia and agranulocytosis
Flunitrazepam (rohypnol)
Lithium
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
7. Primary endogenous substrate for Nitric Oxidase Synthase
Succinylcholine
Arginine
Miosis and constipation
Carboplatin
8. Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
Diazepam
Glyburide - glipizide - and rosiglitazone
Mivacurium
Adenosine
9. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Hot flashes
Dipyridamole
Buprenorphine
PCP
10. Estrogen mostly used in oral contraceptives (OC)
PGE1
Tetracycline
Ethinyl estradiol and mestranol
Tamsulosin
11. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine
Dicyclomine - methscopolamine
Cimetidine
Sodium channel blockade
Thioridazine
12. Sulfonylurea Not recommended for elderly because of very long half life
Chlorpropamide
Buprenorphine
Repaglinide
Log - kill hypothesis
13. DOC for herpes and its MOA
Steady state
Acyclovir; incorporated into viral DNA and chain termination
Buspirone
Digibind
14. Beta blockers partial agonist activity (intrinsic sympathomimetic activity) cause some bronchodilation and may have an advantage in treating patients with asthma
Pindolol and acebutolol
Nitroglycerin sublingual tablets
Aminocaproic acid
Leuprolide
15. Concern using lithium
Raloxifene
Marijuana
Retinal destruction and dermatitis
Low therapeutic index
16. Inhibitor of lipoxygenase
Zileuton
Skeletal muscle tremor - tachycardia
Phentolamine
Thiopental
17. Nitrate used to prevent further attacks
Metrifonate
Oral and transdermal forms of nitroglycerin
Liver toxicity - increased serum cholesterol
Erythropoietin
18. Secondary amines that have less sedation and more excitation effect
Prostaglandin PGF2a
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Nortriptyline - Desipramine
Lispro (Humalog) - aspart - glulisine
19. Arterial vasodilator that works by opening K+ channels
Minoxidil
Ketoconazole
Clonidine - and methyldopa
Celecoxib
20. Median effective dose required for an effect in 50% of the population
Theophylline
Lipoprotein lipase
ED50
Mast cell stabilizer
21. Thrombolytics are used for
Atenolol - acebutolol - and metoprolol
Naloxone
Pulmonary embolism and DVT
Block voltage - dependent sodium channels
22. H2 blocker that causes the most interactions with other drugs
Ezetimibe (Zetia)
Cevimeline
PTU
Cimetidine
23. Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release
Insulin
Affect calcium - potassium - and sodium channels
Ethanol - fomepizole
Presynaptic mu - delta - and kappa receptors
24. Alpha - glucosidase inhibitor associated with elevation of LFT's
Sotalol
Lepirudin
Beta blockers
Acarbose
25. SE of heparin
Low potency phenothiazines and ziprasidone
Heparin induced thrombocytopenia (HIT)
Aztreonam
Neuromuscular blocking drugs
26. Bleomycin+vinblastine+etoposide+cisplatin produce almost a 100% response when all agents are used for this neoplasm
Leuprolide
Testicular cancer
Raloxifene
Fluoxetine (Sarafem)
27. Side effects occuring in antipsychotics that block dopamine
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
lispro insulin - aspart insulin - glulisine insulin
Acebutolol and atenolol
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
28. Agents for reduction of postpartum bleeding
Oxytocin - ergonovine and ergotamine
Fluoxetine (Sarafem)
Theophylline
Amiodarone
29. SE of imipenem
Ipodate
Reducing preload
Interferon alpha
Seizures
30. Epinephrine is often mixed with a local anesthetic to
Alpha1 agonists
Reduce the loss from area of injection
Volume of distribution (VD)
Aspirin - Nitrates - CCB - and Beta blockers
31. Occurs when sedative hypnotics are used chronically or at high doses
Doxepin
Dapsone - rifampin and clofazimine combination
Tolerance
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
32. Antiglaucoma organophosphate
Reduce aqueous secretion
Sodium channel blockers
Echothiophate
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
33. Toxicity of anticholinergics
Salmeterol
block SLUD (salivation - lacrimation - urination - defecation
Muscarinic blockers
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
34. Regimen used for breast cancer
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Glucagon
Rheumatic disease
Potassium channel blockers
35. Treatment for TB patients (think RIPE)
Haloperidol
Gabapentin
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
LD50
36. Routes of administration of heparin
Clopidogrel and ticlopidine
Older antipsychotic agents - D2 receptors
IV and IM (only LMW)
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
37. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Atropine - homatropine - C1208 tropicamide
Tinnitus - GI bleeding
Risperidone
38. Condition will result from in combination of MAOI with tyramine containing foods (ex. wine - cheese - and pickled meats)
Yohimbine
Streptokinase
Hypertensive crisis
Postsynaptic Mu receptors
39. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
Edrophonium
Amitriptyline
Naloxone
Beta blockers
40. MOA of tetracycline
Decreased micro and macro vascular disease
Amitriptyline
Midazolam
Decreases protein synthesis by inhibiting 30S ribosome
41. Sedation is a common side effect of these drugs - they lower seizure threshold - uses include BAD - acute panic attacks - phobias - enuresis - and chronic pain and their overdose can be deadly
Tricyclic antidepressants (TCA)
Neuromuscular blocking drugs
Clonazepam
Prazosin - terazosin and doxazosin (- AZOSIN ending)
42. SE of niacin
Ipodate
Cutaneous flush
Aplastic anemia and renal toxicity
Vitamin K or fresh frozen plasma
43. Tolerance is marked and abstinence syndrome occurs
Classic
Thiopental
Amphetamines
Pilocarpine - carbachol - physostigmine
44. Antidote for tissue plasminogen activator (t - PA) - streptokinase
Severe hypertension
Theophylline
Pulmonary embolism and DVT
Aminocaproic acid
45. Incidence of hyoglycemia with metformin
Geriatrics due to its CNS (depression) effects
Somatrem
Fluoxetine
None
46. Chronic orthostatic hypotension can be treated with
Flutamide (Eulexin)
GFR
Tricyclic antidepressants (TCA)
Midodrine
47. Strong opioid agonists
Albuterol
Tamsulosin (Flomax)
Morphine - methadone - meperidine - and fentanyl
Positive Comb's test - depression
48. Nonselective alpha - blocking drug - short acting and reversible - used for rebound HTN from rapid clonidine withdrawal - and Raynaud's phenomena
Terfenadine and astemizole (have been removed from the market)
Phentolamine
Ticlopidine
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
49. Aminoglycosides used with loop diuretics potentiate adverse effect
Methadone
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Ototoxicity
Bile acid - binding resins
50. Disease caused by excess ergot alkaloids
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