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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep






2. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures






3. Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)






4. Alpha 1selective blockers






5. These agents are used as antitussive






6. Anti - emetics used in association with anti - cancer drugs that are 5- HT3 (serotonin receptor subtype ) antagonists






7. MOA and effect of nitric oxide






8. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose






9. Neurotoxicity with isoniazid (INH) prevented by






10. Well - tolerated and are first - line antidepressants

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11. Major SE of zileuton






12. Agent used to treat chronic gout by increasing uric acid secretion and excretion






13. Most important toxic effects of most local anesthetics






14. 5HT-3 antagonist used in chemotherapeutic induced emesis






15. Skeletal muscle agent that undergoes Hofmann elimination (breaks down spontaneously)






16. Selective Alpha 2 blocker used for impotence (controversial effectiveness)






17. Prototype antagonist of H1 and H2 receptors






18. This may antagonize activity of local anesthetics






19. ADH agonist used for pituitary diabetes insipidus






20. Vitamin given with calcium to ensure proper absorption






21. Reason benzos are used cautiously in pregnancy






22. Drug causing depletion of substance P (vasodilator)






23. Cheap wide spectrum antibiotic DOC for otitis media






24. Treatment of choice for organophosphate overdose






25. Inhaled anesthetic that may sensitize the myocardium to arrhythmogenic effects of catecholamines and has produced hepatitis






26. Treatment for opioid addiction






27. Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis






28. Beta - blockers should be used cautiously in






29. Epinephrine is often mixed with a local anesthetic to






30. Anti - progesterone used as abortifacient






31. Class of drugs with ability to decrease the maximal response to an agonist






32. Tolerance to all effects of opioid agonists can develop except






33. SSRI indicated for premenstrual dysphoric disorder






34. Term for a high margin of safety






35. Agents used in Huntington's Disease






36. The ratio of the rate of elimination of a drug to its plasma concentration






37. Except for these agents all SSRI have significant inhibition of CytP450 enzymes






38. The most important sign of withdrawal syndrome






39. SE of clonidine






40. DOC for tx of pseudomembranous colitis






41. Drug used in exoerythrocytic cycle of malaria






42. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma






43. Site of action of loop diuretics






44. Alternative anticoagulant used if HIT develops






45. These prevent the action of Ach at the skeletal muscle endplate to produce a 'surmountable blockade -' effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)






46. Leads to respiratory depression progressing to coma and death






47. Moderate opioid agonists






48. Drug of choice for generalized anxiety disorder - Not effective in acute anxiety






49. Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates






50. Thrombolytics are used for