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USMLE/COMLEX Step 1 Pharmacology One Liners
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Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Barbiturate used for the induction of anesthesia
Nephro and ototoxicity
Thiopental
Phenoxybenzamine
Geriatrics due to its CNS (depression) effects
2. Oral contraceptive available in a transdermal patch
Ortho - Evra
Ketoralac
Warfarin (PT)
Magnesium sulfate
3. Enzyme that metabolizes acetaldehyde to acetate
Increases concentration of Digoxin
Aldehyde dehydrogenase
TD50
Alprazolam and Clonazepam
4. Nonselective alpha agonists that increases outflow - probably via the uveoscleral veins
Flumazenil
Epinephrine - dipivefrin
Reduce inhibition - suppress anxiety - and produce relaxation
Marijuana
5. Concentration in the plasma times (clearance divided by bioavailability)
Potential for development of Reye's syndrome
Maintenance dose (Cp*(CL/F))
Cyclophosphamide
Steady state
6. Most common SE of fibrates
Vancomycin - infusion at a slow rate and antihistamines
Aspirin - metoprolol
nephro and ototoxicity
Nausea
7. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Interleukin 11 (oprelvekin)
Affinity
Amantadine
GLUT 2
8. Fluoride released by metabolism of this inhaled anesthetic may cause renal insufficiency
GFR
SSRI's - bupropion - and venlafaxine
Methoxyflurane
Cevimeline
9. Beta 2 agonist toxicity
Cyclophosphamide
Apraclonidine - brimonidine
Nephrotoxicity
Skeletal muscle tremor - tachycardia
10. GnRH antagonist with more immediate effects - used for infertility
Full agonist
Ganirelix
Pregnancy
Clindamycin
11. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia
Propoxyphene
Stevens - Johnson syndrome
Sedation
Phenylephrine
12. Metronidazole SE if given with alcohol
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Allopurinol
Disulfiram - like reaction
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
13. Anti - emetics used in association with anti - cancer drugs that are 5- HT3 (serotonin receptor subtype ) antagonists
Odansetron - granisetron
Theophylline
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Orthostatic hypotension (especially with first dose) and reflex tachycardia
14. Diuretic used for mountain sickness and glaucoma
Acetazolamide
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Indomethacin
Cocaine 'super - speed'
15. Prevents thrombosis in patients with artificial heart valve
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Dipyridamole
Hypoglycemia
Cevimeline
16. SSRI with long T1/2 and can be administered once weekly for maintenance - not acute tx
Fluoxetine
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Alkylating agent
LD50
17. Heparin (PTT) increases activity of
Antithrombin 3
Nitrites
GI bleeding
Indomethacin
18. SE of nesiritide
Delavirdine - efavirenz - and ribavirin
Excessive hypotension and kidney failure
Phase I
Atrial fibrillation and CHF
19. Site of action of thiazide diuretics
Hydroxychloroquine
Prazosin - terazosin - doxazosin
Work at early distal convoluted tubule
Dexrazoxane
20. Fibrates (gemfibrozil) increase activity of
Miosis and constipation
Mechlorethamine
Pregnancy
Lipoprotein lipase
21. Except for these agents all SSRI have significant inhibition of CytP450 enzymes
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Citalopram and its metabolite escitalopram
Ascending pathways
Gingival hyperplasia
22. Benzodiazepine that is used for anesthesia
Gastric ulcers and GI Bleeding
Midazolam
Ascending pathways
Olanzapine
23. SE of phenytoin
Carboplatin
Gingival hyperplasia - nystagmus - diplopia and ataxia
Ribavirin
Cyanide toxicity treated with sodium thiosulfate
24. Common SE of sulfonylureas - repaglinide - and nateglinide
Aminoglutethimide
Bile acid - binding resins
Hypoglycemia
Fluphenazine and haloperidol
25. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Sumatriptan
Ketoralac
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Halothane and methoxyflurane
26. Agent having no effect on D2 receptors - blocks D4 - reserved for resistant schizophrenia - and can cause fatal agranulocytosis
Zolpidem - zaleplon
Interleukin 11 (oprelvekin)
Salmeterol
Clozapine
27. This beta blocker is highly lipid soluble and may account for side effects such as nightmares
Propranolol
Zolpidem
Indomethacin
Zero order kinetics
28. Receptors for serotonin (5HT-1) are located
Didanosine
Tricyclic antidepressants (TCA)
Sermorelin
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
29. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Potency
Estrogen
Timolol
Steady state
30. MOA of local anesthetics (LA's)
Ganciclovir - zidovudine - saquinavir - and interferon
Block voltage - dependent sodium channels
Additive CNS depression
Amiodarone
31. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
Aminoglutethimide
Magnesium sulfate
Spasmolytic drugs
Sedation
32. Converts asparagine to aspartate and ammonia - denies cancer cells of essential AA (asparagine)
Atracurium
L- asparaginase
Midodrine
Islets of Langerhans
33. Agent that is a partial agonist for the 5- HT1A receptor
Aspirin
Pulse therapy
Vasodilation
Buspirone
34. Agents used in Tourette's dx
Haloperidol or pimozide
Prilocaine
Dopamine
Neutro - leuko and thrombocytopenia
35. Life threatening cardiac event that prolong QT leads to
Thyroxine
Vancomycin
Torsades de pointes
Hypertensive crisis
36. Drug used in Chagas disease
Mifepristone
Etidronate
ACE inhibitors
Nifurtimox
37. Carbamazepine may cause
Heparin
Depression of medullary and cardiovascular centers
Agranulocytosis
Codeine - hydrocodone - and oxycodone
38. Endogenous insulin contains
Dimercaprol
Interferon alpha
Normal C- peptide
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
39. Arterial vasodilator that works by opening K+ channels
Minoxidil
CNS depressants
Prazosin - terazosin - doxazosin
NO - chloroform - and diethyl ether
40. Well - tolerated and are first - line antidepressants
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41. Antidote used for warfarin toxicity
Spironolactone
Fluoxetine
Vitamin K and Fresh frozen plasma (FFP)
Imipramine
42. Site of action for zaleplon and zolpidem
Vitamin D
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Hypertensive crisis
'On - off - phenomenon'
43. SE of both warfarin and heparin
Bromocriptine
Bleeding
Steroids
LFT's
44. Agent to treat hypochromic microcytic anemias
Sedation
Ferrous sulfate
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Ethanol
45. Antidote used for lead poisoning
Dimercaprol - EDTA
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Carvedilol
Physostigmine
46. SE of long term (>5 days) corticosteroid therapy and remedy
Beta blockers
Adrenal suppression and weaning slowly - respectively
Celecoxib
Bioavailability (F)
47. Antidote used for anticholinergic poisoning
Nitroglycerin sublingual tablets
Valproic acid
Beta blockers
Physostigmine
48. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Isoflurane
Naloxone (IV) - naltrexone (PO)
Thioridazine
Tertiary amines
49. Epinephrine is often mixed with a local anesthetic to
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Reduce the loss from area of injection
Stimulates cGMP which leads to vascular smooth muscle relaxation
Gabapentin
50. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
Prinzmetal's angina
Acetazolamide
Amitriptyline
Beta blockers
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