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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Pneumonic for beta receptors
Inhibit Cytochrome P450 3A4
CNS depressants
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Iron deiodinates thyroxine
2. Anti - psychotic not shown to cause tardive dyskinesia
Glucocorticoids
Thyroxine
Clozapine
Aldehyde dehydrogenase
3. Lactam that can be used in PCN allergic patients
Nitroprusside
Raloxifene
Aztreonam
Interferon alpha
4. Antipsychotic having the weakest autonomic effects
Valproic acid
Lithium
Urinary acidification and activated charcoal or continual nasogastric suction
Haloperidol
5. Increased risk of developing cataracts
Chlorpheniramine or cyclizine
Quetiapine
Oxybutynin - dicyclomine
Selective inhibitor of microtubule assembly
6. Concern using lithium
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Low therapeutic index
Propoxyphene
GABA- related targets
7. SE for Lamotrigine
Zero order kinetics
Aspirin
Stevens - Johnson syndrome
Thioridazine
8. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients
Bupropion
Vitamin K or fresh frozen plasma
Beta blockers
Digibind
9. Carbonic anhydrase inhibitor
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
Iron deiodinates thyroxine
Reduce aqueous secretion
Acetazolamide
10. Used for prevention of postmenopausal osteoporosis in women
Estrogen (HRT- Hormone replacement therapy)
Pregnancy
Nitroprusside
Carbidopa
11. Condition will result from in combination of MAOI with tyramine containing foods (ex. wine - cheese - and pickled meats)
Hypertensive crisis
NSAIDS
Iron deiodinates thyroxine
Erythromycin
12. Anticoagulant of choice in pregnancy
DOM - STP - MDA - and MDMA 'ecstasy'
Cocaine and benzocaine
Heparin
Oral
13. Moderate opioid agonists
Acetazolamide
Seizures
Codeine - hydrocodone - and oxycodone
Venlafaxine
14. Mast cells to reduce release of hisamine and inflammatory mediators
Ketanserin cyproheptadine - and phenoxybenzamine
Epinephrine
Valproic acid
Skeletal muscle tremor - tachycardia
15. Facilitates GABA presynaptic inhibition
Fludrocortisone and deoxycorticosterone
Toremifene (Fareston)
Diazepam
GLUT 2
16. Prostaglandin used in the treatment of impotence
Alprostadil
Acarbose
Fluoxetine
Indomethacin
17. Agent for pernicious anemia
Ethinyl estradiol and mestranol
Cyanocobalamin (Vit B12)
Arginine
Aminocaproic acid
18. Nitrate used for acute anginal attacks
Use in IgE mediated allergic reaction
Nefazodone
Nitroglycerin sublingual tablets
Amiodarone
19. Antivirals that are teratogens
Marijuana
Tubocurarine
PGE1
Delavirdine - efavirenz - and ribavirin
20. Opioids used in anesthesia
Hepatic toxicity
Gingival hyperplasia - nystagmus - diplopia and ataxia
Morphine and fentanyl
Minimum alveolar anesthetic concentration (MAC)
21. Long acting beta 2 agonist used in asthma
Salmeterol
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Tamsulosin
Heparin induced thrombocytopenia (HIT)
22. Decreases liver triglycerol synthesis
Ganciclovir - zidovudine - saquinavir - and interferon
Nitroprusside
Acetazolamide
Niacin
23. Important in muscle and adipose tissue for glucose transport across muscles and TG storage by lipoprotein lipase activation
Glucocorticoids
LSD
Naloxone
GLUT 4
24. Agent used to treat MI and to reduce incidence of subsequent MI
Warfarin (PT)
Testicular cancer
Inhibit Na+/Cl - cotransport
Aspirin - metoprolol
25. Toxic effect of anticancer drug can be lessened by rescue agents
Excessive hypotension and kidney failure
Mechlorethamine
Meperidine
Rescue therapy
26. Used especially in postmenopausal women - dosage should be 1500 mg
Calcium
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Carbamazepine
Octreotide
27. Class of drugs whose MOA utilizes ligand gated ion channels
Ribavirin
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Benzodiazepines and calcium channel blockers
Cocaine and benzocaine
28. State of analgesia and amnesia produced when fentanyl is used with droperidol and nitrous oxide
Neuroleptanesthesia
Hepatotoxicity
Hydroxychloroquine
Half - life (T1/2)
29. Penicillins active against penicillinase secreting bacteria
Ticlopidine
Peripheral neuritis and hepatitis
Methicillin - nafcillin - and dicloxacillin
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
30. Aspirin is contraindicated in children with viral infection
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31. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction
Respiratory failure
Minimum alveolar anesthetic concentration (MAC)
Vitamin D
Pilocarpine - carbachol - physostigmine
32. Dose which is lethal to 50% of the population
Magnesium sulfate
Nausea
LD50
Rhabdomyolysis
33. Anti - viral with a dose limiting toxicity of pancreatitis
Vincristine
Indomethacin
Didanosine
Oral and transdermal forms of nitroglycerin
34. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation
Scotch tape technique and mebendazole
Pulmonary embolism and DVT
Hydroxychloroquine
Olanzapine - aripiprazole - and sertindole
35. Peptide causing increased capillary permeability and edema
Tamsulosin (Flomax)
Hypercalcemia
Reducing preload
Bradykinin and histamine
36. SE for ticlopidine
Neutropenia and agranulocytosis
Oral
Antipyretic and analgesic activity
Venlafaxine
37. Toxicity of amphotericin
Terfenadine and astemizole (have been removed from the market)
Ganirelix
Ethanol or fomepizole
Nephrotoxicity
38. Newer atypical antipsychotic used for bipolar disorder - known to cause weight gain - and adversely affect diabetes
high doses
Olanzapine
Aplastic anemia and renal toxicity
Aztreonam
39. SE of methyldopa
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40. Non - benzodiazepine used for sleep
Tetracaine and bupivacaine
Sinus tachycardia and serious arrhythmias
Zolpidem
Selective inhibitor of microtubule assembly
41. Anti - psychotics available in depot preparation
Clopidogrel and ticlopidine
Fluphenazine and haloperidol
Aplastic anemia and acute hepatic failure
Glyburide - glipizide - glimepiride - etc.
42. Anti - seizure drugs used also for pain of neuropathic orgin
Glucuronate - acetic acid - and glutathione sulfate
nephro and ototoxicity
Gabapentin
Potency
43. Antidote useful for some drug induced Torsade de pointes
Magnesium sulfate
Adrenal suppression and weaning slowly - respectively
Olanzapine - aripiprazole - and sertindole
Thyroxine
44. Prevents thrombosis in patients with artificial heart valve
Ganciclovir
Dipyridamole
Prednisone
Drug induced Parkinsonism
45. MOA of nitrates
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Cyproterone acetate
Sermorelin
46. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
Glargine (Lantus) - detemir
Digibind
Aminoglutethimide
Somatrem
47. Direct vasodilator of arteriolar smooth muscle
Metrifonate
Hydralazine
Islets of Langerhans
Methotrexate
48. Longer acting local anesthetics which are less dependent on vasoconstrictors
Inhibit dihydropteroate synthase
Labetalol and carvedilol
Tetracaine and bupivacaine
Carmustine (BCNU) and lomustine (CCNU)
49. Antidote used in poisonings: copper (Wilson's disease) - lead - mercury - and arsenic
Bind ergosterol in fungal cell membrane
Maprotiline
Penicillamine
IV administration
50. NSAID that is used for acute condition - such as pre - op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
Decrease arterial blood pressure
Hydroxychloroquine
Ketoralac
Increases concentration of Digoxin