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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Anemia caused by trimethoprim
Flutamide (Eulexin)
Megaloblastic anemia
Pramipexole and ropinirole
Meperidine
2. SE of thiazide (HCTZ) diuretics
Stevens - Johnson syndrome
Half - life (T1/2)
Hyperuricemia - hypokalemia and hyperglycemia
L- dopa
3. Major SE of zileuton
Zolpidem
Metronidazole
Salmeterol
Liver toxicity
4. Facilitates GABA presynaptic inhibition
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Diazepam
Thyroxine
Glyburide - glipizide - glimepiride - etc.
5. Most common side effect of 1st generation antihistamines
Sedation
Verapamil
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Bromocriptine
6. Enzyme that metabolizes acetaldehyde to acetate
Nondepolarizing Neuromuscular Blockers
Cartilage damage
Yohimbine
Aldehyde dehydrogenase
7. Skeletal muscle agent that can block muscarinic receptors
Decrease arterial blood pressure
Probenecid and sulfinpyrazone
Pancuronium
Half - life (T1/2)
8. Treatment for TB patients (think RIPE)
Volume of distribution (VD)
Verapamil
Ascending pathways
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
9. Major SE of insulin
Infliximab
Hypoglycemia
Spironolactone
LSD
10. Causes acne - premature closure of epiphyses - masculinization in females - hepatic dysfunction - MI - and increases in libido and aggression
Acetazolamide
Fentanyl
Steroids
Isoflurane
11. Atypical antipsychotic causing high prolactin levels
Risperidone
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Procarbazine
NSAIDS
12. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
GI bleeding
inhibits Na+/K+/2Cl - cotransport
hydroxyzine (Atarax)
Amitriptyline
13. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation
Low potency phenothiazines and ziprasidone
Halothane
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Glucagon
14. Osmotic diuretic used to treat increased intracranial pressure
Mannitol
Inhibit dihydropteroate synthase
Combination oral contraceptives (OC)
Clopidogrel and ticlopidine
15. DOC for tx of pseudomembranous colitis
Fluphenazine and haloperidol
Amoxicillin
Red urine discoloration
Metronidazole
16. Well - tolerated and are first - line antidepressants
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17. PCN active against pseudomonas
Bioavailability (F)
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Presynaptic mu - delta - and kappa receptors
Carbenicillin - piperacillin and ticarcillin
18. Distribution of histamine receptors H1 - H2 - and H3
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Methadone - followed by slow dose reduction
Methoxyflurane
Potential for development of Reye's syndrome
19. DOC for status epilepticus
Alprostadil
Diazepam
Decreased micro and macro vascular disease
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
20. DMARDs are slow acting drugs for
Rheumatic disease
Diazepam
Midodrine
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
21. Organophosphate anthelmintic agent with long DOA
Cerebral hemorrhage
Cevimeline
Calcium channel blockers
Metrifonate
22. Carbonic anhydrase inhibitor
Acetazolamide
inhibits HMG COA reductase
AZT (zidovudine)
Cefixime (3rd) generation
23. Usual time needed for full effect of antidepressant therapy
2 to 3 weeks
Decreased micro and macro vascular disease
Liver enzyme INDUCTION
Cyclophosphamide
24. Hormone inhibiting prolactin release
Dopamine
Salmeterol
Mifepristone
Red urine discoloration
25. Alpha 1selective blockers
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Calcium
Fludrocortisone and deoxycorticosterone
Arteries and veins
26. Amino acid derivative - active as an insulin secretagogue
Nateglinide
Leuprolide
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Lithium toxicity
27. Vascular effects of metformin
Diphenoxylate - Loperamide
Decreased micro and macro vascular disease
Magnesium sulfate
Serum ammonia and LFT's
28. Drugs of choice for absence seizures
Valproic acid - carbamazepine - phenytoin and gabapentin
Pregnancy
Acebutolol and atenolol
Ethosuximide and valproic acid
29. Chronic orthostatic hypotension can be treated with
Atracurium
Loading dose (Cp*(Vd/F))
ED50
Midodrine
30. Common side effect of Rifampin
Infants
Red urine discoloration
First pass effect
Degradation of fibrin clots and are administered IV
31. SE of alpha blockers
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Sumatriptan
L- dopa
Atropine - pralidoxime (2- PAM)
32. Aspirin reduces mortality in unstable angina by
Nitroprusside
Platelet aggregation inhibition
Nefazodone
Testosterone
33. Antidote used for carbon monoxide poisoning
Vitamin B12
Mifepristone
Reduce the loss from area of injection
100% O2 and hyperbaric O2
34. Associated with an increased incidence of cataracts in patients treated for glaucoma
Diazepam
Pre - existing cardiac or renal disease
Long acting cholinesterase inhibitors
Torsades de pointes
35. MOA of corticosteroids
Betamethasone and dexamethasone
Positive Comb's test - depression
Timolol
inhibit phospholipase A2
36. Agent that is the antidote for methanol overdose
Ethanol - fomepizole
Drug induced Parkinsonism
Hypertrichosis
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
37. Antipsychotics that reduce positive symptoms only
Theophylline
Older antipsychotics
Epinephrine
Ezetimibe (Zetia)
38. Antidepressant inhibiting norepinephrine - serotonin - and dopamine reuptake
Ezetimibe (Zetia)
Venlafaxine
Barbiturates - phenytoin - carbamazepine - and rifampin
PGE1
39. Drug that causes gray baby syndrome and aplastic anemia
Cyproterone acetate
Estrogen
Fentanyl
Chloramphenicol
40. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Fentanyl
Bupropion
5-7 days
B- blockers
41. Thiazolidinediones
Nortriptyline - Desipramine
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Cholinesterase inhibitors
Esmolol
42. Inhaled anesthetic that may sensitize the myocardium to arrhythmogenic effects of catecholamines and has produced hepatitis
Hepatic enzymes
Neostigmine
Muscarinic blockers
Halothane
43. Antidepressants with no effect on BP - no sedation
Pramipexole and ropinirole
Timolol (nonselective) - betaxolol (selective)
SSRIs
Nitrous oxide
44. Peptide causing increased capillary permeability and edema
Ganciclovir - zidovudine - saquinavir - and interferon
Ketoralac
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
Bradykinin and histamine
45. NSAID contraindicated in gout
Sodium channel blockers
Aspirin
Noncompetitive antagonist
Hypertensive crisis
46. Term for a high margin of safety
Disulfiram - like reaction
High therapeutic index
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Naloxone
47. Median effective dose required for an effect in 50% of the population
Hypoglycemia
Uterine contractions
Malathion
ED50
48. Moderate opioid agonists
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Paclitaxel (taxol)
Codeine - hydrocodone - and oxycodone
Hepatic toxicity
49. Antipsychotic having the strongest autonomic effects
Thioridazine
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Apraclonidine - brimonidine
Indomethacin
50. DOC for influenza A
Stevens - Johnson syndrome
Digibind
Glucagon
Amantadine