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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Antidepressant associated with neuroleptic malignant syndrome
Affinity
Leuprolide
Dexamethasone suppression test
Amoxapine
2. Pungent inhaled anesthetic which leads to high incidence of coughing and vasospasm
Physostigmine
GLUT 4
Desflurane
Interleukin 11 (oprelvekin)
3. Common mechanism by which overdose result in death
Depression of medullary and cardiovascular centers
Additive CNS depression
increase the FREQUENCY of GABA- mediated chloride ion channel opening
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
4. Site of action for zaleplon and zolpidem
Thrombocytopenic purpura - and CINCHONISM
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Benzodiazepines and calcium channel blockers
Sumatriptan - naratriptan - and rizatriptan
5. Agents having higher sedation and antimuscarinic effects than other TCA's
Dantrolene
Phenytoin
Fexofenadine - loratadine - and cetirizine
Tertiary amines
6. Increase bone density - also being tested for breast CA prophylaxis
Esmolol
Deferoxamine
Raloxifene (SERM- selective estrogen receptor modulator)
Bupropion
7. Atropine fever is the most dangerous effect and can be lethal in this population group
Cholinesterase inhibitors
Atrial fibrillation and CHF
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Infants
8. Alternative anticoagulant used if HIT develops
Zolpidem
Clomiphene and tamoxifen
Lepirudin
Ganciclovir - zidovudine - saquinavir - and interferon
9. Drug used in cancer therapy causes Cushing - like symptoms
Pamidronate - zoledronate - ibandronate
CNS depressants
Reducing preload
Prednisone
10. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Indomethacin
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Glucocorticoids
Organic nitrites
11. Leads to respiratory depression progressing to coma and death
Tamsulosin
Overdose of opioids
Indomethacin
Liver toxicity
12. Lactam that can be used in PCN allergic patients
Aztreonam
Chemical esophagitis
Hydroxychloroquine
Carbamazepine - gabapentin - lamotrigine - and valproic acid
13. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion
Thioridazine
Sotalol
Oxidation - reduction - hydrolysis
Side - effect profile and prior pt response
14. Longer acting local anesthetics which are less dependent on vasoconstrictors
Tetracaine and bupivacaine
Ipratropium
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
15. Ergot alkaloid that is a partial agonist at D2 receptors in the brain - used for patients who are refractory or cannot tolerate levodopa - causes erythromelalgia
100% O2 and hyperbaric O2
Carvedilol
Odansetron
Bromocriptine
16. Converts asparagine to aspartate and ammonia - denies cancer cells of essential AA (asparagine)
Abstinence syndrome
Propofol
L- asparaginase
IV administration
17. Drugs used in the management of angina
Pulse therapy
Gynecomastia and hyperkalemia
Aspirin - Nitrates - CCB - and Beta blockers
Cyanocobalamin (Vit B12)
18. Osmotic diuretic used to treat increased intracranial pressure
Raloxifene
Mannitol
Normal C- peptide
Dimenhydrinate - meclizine - and other 1st generation
19. Product of proinsulin cleavage used to assess insulin abuse
Carbamazepine
Methotrexate
C- peptide
Aspirin - Nitrates - CCB - and Beta blockers
20. Metronidazole SE if given with alcohol
Tetracaine and bupivacaine
Venlafaxine
Disulfiram - like reaction
Dobutamine and dopamine
21. Example of three antidepressants that are indicated for obsessive compulsive disorder
Tetracaine and bupivacaine
Fluorocarbons and Industrial solvents
Clomipramine - fluoxetine and fluvoxamine
Protamine sulfate
22. Antipsychotic having the weakest autonomic effects
Haloperidol
Calcium channel blockers
Disulfiram - like reaction
Selegiline
23. SE of HMG COA reductase inhibitors
Antipyretic and analgesic activity
Rhabdomyolysis and Hepatotoxicity
Full agonist
Cosyntropin
24. Diuretic used to treat primary aldosteronism
Esmolol
Barbiturates - phenytoin - carbamazepine - and rifampin
Spironolactone
Aminocaproic acid
25. DOC for status epilepticus
Ethanol
Pindolol and acebutolol
Baclofen
Diazepam
26. Antidote used for iron salt toxicity
Apraclonidine - brimonidine
Deferoxamine
Alkylating agent
Edrophonium
27. Anti - psychotic not shown to cause tardive dyskinesia
Na+/K+ exchange
N- acetylcysteine
Clozapine
hydroxyzine (Atarax)
28. Anti - seizure drugs used also for pain of neuropathic orgin
Neuroleptanesthesia
Gabapentin
Edrophonium
Zafirlukast and montelukast
29. This may enhance activity of local anesthetics
Infants
Pralidoxime
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Hyperkalemia
30. Anti - seizure drugs used also for Trigeminal neuralgia
Ultralente (humulin U)
Penicillamine
Carbamazepine
Vitamin D
31. Amphetamine agents
Methotrexate
Dextroamphetamines and methamphetamine
Pyridostigmine
TD50
32. NSAID also available as an ophthalmic preparation
Lupus - like syndrome
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Diclofenac - ketoralac
Mechlorethamine
33. Antidote for beta - blockers and hypoglycemia
Amiodarone
SEVERE myelosuppression
PGE1
Glucagon
34. Rapid acting insulins that do not self - aggregate
Tamsulosin (Flomax)
lispro insulin - aspart insulin - glulisine insulin
Na+/K+ exchange
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
35. Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release
Presynaptic mu - delta - and kappa receptors
Ethanol - fomepizole
Long acting cholinesterase inhibitors
Esmolol
36. Antidote used for lead poisoning
Zolpidem
Dimercaprol - EDTA
Spasmolytic drugs
Dicyclomine - methscopolamine
37. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Cardiac anomalies and is contraindicated in pregnancy or lactation
ACE inhibitors
Valproic acid - carbamazepine - phenytoin and gabapentin
38. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism
Thioridazine
Methimazole and propylthiouracil (PTU)
Iodide salts
Nitrous oxide
39. MOA of class I A (eg. Procainamide) - class IB (eg. Lidocaine) - and class IC (eg. Flecainide) antiarrhythmics
Atropine - homatropine - C1208 tropicamide
Radioactive iodine
5- flouracil (5- FU)
Sodium channel blockers
40. MOA of nesiritide
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Increasing sodium excretion and decreases arterial and venous tone
Aminocaproic acid
Ultralente (humulin U)
41. Major drug interaction with Quinidine
Increases concentration of Digoxin
Clomipramine - fluoxetine and fluvoxamine
Severe hypertension
Octreotide
42. Opioid used in the management of withdrawal states
Red urine discoloration
Reduce inhibition - suppress anxiety - and produce relaxation
Ethanol
Methadone
43. Anti - seizure agent that exhibits non - linear metabolism - highly protein bound - causes fetal hydantoin syndrome - and stimulates hepatic metabolism
Naltrexone
Phenytoin
Buspirone
Ethanol
44. Methylxanthine derivative used as a remedy for intermittent claudication
Pentoxifylline
Deferoxamine
Topical mupirocin (Bactroban)
Selective inhibitor of microtubule assembly
45. Plasma concentration of a drug at a given time
Skeletal muscle tremor - tachycardia
Leuprolide
Cp
Side - effect profile and prior pt response
46. MOA of neuroleptics
Carmustine (BCNU) and lomustine (CCNU)
Dopamine blockade
Mifepristone
Metrifonate
47. MOA of both generations
Propoxyphene
Glyburide - glipizide - and rosiglitazone
Insulin release from pancreas by modifying K+ channels
Meperidine
48. Agents used in Tourette's dx
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Prolonged half - life - up to six weeks
Haloperidol or pimozide
Buspirone
49. These agents are used as antidiarrheal
ED50
Pralidoxime - atropine
Diphenoxylate - Loperamide
Iodide salts
50. Hormone inhibiting prolactin release
Dopamine
Vancomycin - infusion at a slow rate and antihistamines
Tinnitus - GI bleeding
Phenytoin