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USMLE/COMLEX Step 1 Pharmacology One Liners
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Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. MOA of tetracycline
Lupus - like syndrome
Alprostadil
IV administration
Decreases protein synthesis by inhibiting 30S ribosome
2. Agents used in treatment of carcinoid tumor
Ketanserin cyproheptadine - and phenoxybenzamine
Mifepristone (RU-486)
Reduce aqueous secretion
B- blockers
3. Alpha 1 agonist toxicity
Hypoglycemia
Hypertension
Pregnancy
Scotch tape technique and mebendazole
4. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
ACE inhibitors
Haloperidol
Metrifonate
Additive CNS depression
5. Adenosine's MOA
B- blockers
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Hot flashes
Maintenance dose (Cp*(CL/F))
6. Non - depolarizing skeletal muscle antagonist that has short duration
Mivacurium
Salmeterol
Amphetamines
Streptokinase
7. Side effects occuring in antipsychotics that block dopamine
Clearance (CL)
Protamine
Dolasetron
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
8. Treat manifestations of Parkinson's disease and EPS
Levodopa
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Benztropine - trihexyphenidyl
Overdose of opioids
9. SE for Lamotrigine
Hydroxychloroquine
Hydroxychloroquine
Stevens - Johnson syndrome
Abciximab - tirofiban and eptifibatide
10. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors
Cyproheptadine
Octreotide
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Beta - blockers
11. Drug is used with testosterone for male fertility
Beta - blockers such as propranolol
Dopamine blockade
Naloxone
Leuprolide
12. Antidote used for organophosphate/anticholinesterase poisoning
Adenosine
Insulin glargine
Atropine - pralidoxime (2- PAM)
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
13. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)
Albuterol
Timolol
Ethanol
Thyroxine
14. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
Succinylcholine
Temazpam - trizolam - flurazepam
Amitriptyline
Maintenance dose (Cp*(CL/F))
15. Vancomycin MOA
Blocks peptidoglycan synthesis
High therapeutic index
Chlordiazepoxide and Diazepam
Bupropion
16. Population group especially sensitive to side effects of antidepressants
Elderly patients
Risperidone
Fluoxetine
Epinephrine
17. PTU (propylthiouracil) MOA
Diphenoxylate - Loperamide
Bioavailability (F)
Fentanyl
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
18. SE of imipenem
First pass effect
Seizures
Venlafaxine
Postsynaptic Mu receptors
19. Rapid acting - crystalline zinc insulin used to reverse acute hyperglycemia
Amantadine
Insulin
Regular (Humulin R)
Magnesium sulfate
20. Mediator of tissue pain - edema - inactivated by ACE - and may be a contributing factor to the development of angioedema
Bradykinin
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Protamine
Prolongs QT interval
21. Angiotensin receptor blockers do Not cause
GI bleeding
Thyroid and steroid hormones
Older antipsychotics
Dry cough
22. MOA and effect of nitric oxide
Prinzmetal's angina
Stimulates cGMP which leads to vascular smooth muscle relaxation
Methotrexate
Iron deiodinates thyroxine
23. Concentration in the plasma times (clearance divided by bioavailability)
Nephro and ototoxicity
Penicillamine
Maintenance dose (Cp*(CL/F))
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
24. The fraction of administered dose of a drug that reaches systemic circulation
Labetalol and carvedilol
GFR
Scopolamine - meclizine
Bioavailability (F)
25. SE of salicylates
Amrinone and milrinone
Dimercaprol
Propranolol
Tinnitus - GI bleeding
26. Important in synthesis of glucose to glycogen in the liver
GLUT 2
Gynecomastia hyperkalemia - and impotence
Reducing progression of heart failure (never use in acute heart failure)
Cocaine
27. Antiprogestin used as potent antagonist of GC receptor
Sulfonamides
Mifepristone
Metronidazole
GLUT 2
28. Major effect of benzodiazepines on sleep at high doses
REM is decreased
Calcium channels
Beta1 agonists
Adenosine
29. A hormone whose mechanism of action (MOA) utilizes intracellular receptors
Pramipexole and ropinirole
Propranolol
Thyroid and steroid hormones
Neutro - leuko and thrombocytopenia
30. W/D from this drug causes anxiety and mental discomfort
Respiratory failure
Digibind
Neuroleptanesthesia
Nicotine
31. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Neostigmine
Halothane and methoxyflurane
Rheumatic disease
Aminoglutethimide
32. Opioid that can be given PO - by epidural - and IV - which helps to relieve the dyspnea of pulmonary edema
Minocycline
Indomethacin
Morphine
Beta1 agonists
33. Very rapid acting insulin - having fastest onset and shortest duration of action
Carmustine (BCNU) and lomustine (CCNU)
Lispro (Humalog) - aspart - glulisine
Fomepizole
Methadone - followed by slow dose reduction
34. Associated with an increased incidence of cataracts in patients treated for glaucoma
Thiopental
Long acting cholinesterase inhibitors
Cimetidine
Low - potency typical antipsychotics and clozapine
35. Bleomycin+vinblastine+etoposide+cisplatin produce almost a 100% response when all agents are used for this neoplasm
Aspirin
Testicular cancer
Phenylephrine
Zolpidem - zaleplon
36. SE of nitrates
Leuprolide
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Nephro and ototoxicity
Sulfonamides
37. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine
Sodium channel blockade
First order kinetics
Clonidine - and methyldopa
Meperidine
38. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis
Bleomycin
Aminocaproic acid
Ortho - Evra
Entacapone and Tolcapone
39. SelectiveB1 Receptor blockers that may be useful in treating patients even though they have asthma
Fluphenazine and haloperidol
Nevirapine - amprenavir
Acebutolol - atenolol - esmolol - metoprolol
Chlorpheniramine or cyclizine
40. DOC for influenza A
Retinal destruction and dermatitis
Meperidine
Excessive hypotension and kidney failure
Amantadine
41. Most frequent route of metabolism
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Hepatic enzymes
Aspirin - Nitrates - CCB - and Beta blockers
Beta - blockers
42. Patients being treated with lithium - who are dehydrated - or taking diuretics concurrently - could develop
Midazolam
Verapamil
Affinity
Lithium toxicity
43. This beta blocker is highly lipid soluble and may account for side effects such as nightmares
Clozapine
Propranolol
Hallucinations resembling psychosis
Insulin release from pancreas; faster and shorter acting than sulfonylurea
44. Anti - arrhythmics that decrease mortality
B- blockers
Edrophonium
Yohimbine
Point mutation
45. Antidote used for heparin overdose
Estrogen
Atenolol - acebutolol - and metoprolol
Protamine
Opioid Analgesics
46. Second generation sulfonylurea
Glyburide - glipizide - glimepiride - etc.
Spironolactone
Low therapeutic index
Heparin
47. Maximum response achieveable from a drug
Fluoxetine
Bind ergosterol in fungal cell membrane
Efficacy
Valproic acid
48. Cutaneous flush and be reduced by pretreatment with
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Ipodate
Aspirin
TD50
49. Benzodiazepines that are the most effective in the treatment of panic disorder
Postsynaptic Mu receptors
Apraclonidine - brimonidine
Alprazolam and Clonazepam
Amiodarone
50. The ratio of the rate of elimination of a drug to its plasma concentration
Clearance (CL)
Pre - existing cardiac or renal disease
Betamethasone and dexamethasone
Acyclovir; incorporated into viral DNA and chain termination
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