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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Diuretics work in CHF by
Degradation of fibrin clots and are administered IV
Naloxone
Reducing preload
Increasing sodium excretion and decreases arterial and venous tone
2. Antiplatelet drug reserved for patients allergic to aspirin
Full agonist
Epinephrine - dipivefrin
Ticlopidine
Demeclocycline
3. Beta 1 agonists used in acute CHF
Dobutamine and dopamine
Cisplatin
Increased thromboembolic events
100% O2 and hyperbaric O2
4. Agent used in acutely decompensated CHF resembling natriuretic peptide
Nesiritide (Natrecor)
Dextroamphetamines and methamphetamine
Infants - closed angle glaucoma - prostatic hypertrophy
Retinal destruction and dermatitis
5. Chelating agent used in Wilson's disease
Norepinephrine and serotonin
Morphine - methadone - meperidine - and fentanyl
Penicillamine
Phase I
6. Anti - psychotic not shown to cause tardive dyskinesia
Aldehyde dehydrogenase
Digibind
Metrifonate
Clozapine
7. SE of amrinone
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Dimercaprol - EDTA
GLUT 2
Thrombocytopenia
8. GnRH antagonist with more immediate effects - used for infertility
Ganirelix
Esmolol
Morphine - methadone - meperidine - and fentanyl
Hypoglycemia
9. Long acting glucocorticoids
Acebutolol and atenolol
Flumazenil
Betamethasone and dexamethasone
Noncompetitive antagonist
10. Very rapid acting insulin - having fastest onset and shortest duration of action
2 to 3 weeks
Nephrotoxicity
Ferrous sulfate
Lispro (Humalog) - aspart - glulisine
11. Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
Diazepam
Patches - gum - nasal spray - psychotherapy - and bupropion
Bupropion
SSRIs
12. SE for ganciclovir
Increase the DURATION of GABA- mediated chloride ion channels
Atracurium
Neutro - leuko and thrombocytopenia
Probenecid and sulfinpyrazone
13. Reduced seizure threshold
Low - potency typical antipsychotics and clozapine
Dexamethasone suppression test
Nausea
Vitamin K or fresh frozen plasma
14. Toxicity of organophosphate:
Affect calcium - potassium - and sodium channels
Acetazolamide
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Patches - gum - nasal spray - psychotherapy - and bupropion
15. Agents having higher sedation and antimuscarinic effects than other TCA's
Tertiary amines
Cyproterone acetate
Propranolol
Pregnancy
16. Arterial vasodilator that works by opening K+ channels
Didanosine
Peripheral neuritis and hepatitis
Pulmonary embolism and DVT
Minoxidil
17. MOA of metformin
Liver enzyme INDUCTION
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Gingival hyperplasia
Erythropoietin
18. Nitrate used for acute anginal attacks
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Nitroglycerin sublingual tablets
AZT (zidovudine)
19. MOA of corticosteroids
Naloxone (IV) - naltrexone (PO)
inhibit phospholipase A2
Octreotide
Deferoxamine
20. Prostaglandin used in the treatment of impotence
Albuterol
Alprostadil
Raloxifene (SERM- selective estrogen receptor modulator)
B- blockers
21. SE of mirtazapine
Liver toxicity - increased serum cholesterol
Etidronate
Hypokalemia
Glucuronate - acetic acid - and glutathione sulfate
22. HIV med used to reduce transmission during birth
Prolonged half - life - up to six weeks
Prazosin - terazosin - doxazosin
AZT (zidovudine)
Insulin glargine
23. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression
Dantrolene
Morphine - methadone - meperidine - and fentanyl
Terbutaline
Carboplatin
24. Contraindications to use of atropine
Constipation - edema - and headache
Odansetron
Infants - closed angle glaucoma - prostatic hypertrophy
Clonidine - and methyldopa
25. SE of procainamide
Cyanide toxicity treated with sodium thiosulfate
Organic nitrites
Lupus - like syndrome
Clearance (CL)
26. What do beta cells in the pancreas produce?
Insulin
Estrogen (HRT- Hormone replacement therapy)
6- mercaptopurine (6- MP)
Leuprolide
27. Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release
Ticlopidine
Presynaptic mu - delta - and kappa receptors
Pralidoxime
Hypoglycemia
28. H1 antagonist used in motion sickness
Diethylstilbestrol (DES)
Amoxapine
Betamethasone and dexamethasone
Dimenhydrinate - meclizine - and other 1st generation
29. Similar to clonidine and may cause hypotension
None
Tizanidine
Deferoxamine
Nevirapine - amprenavir
30. Opioid available trans - dermally
Fentanyl
Lepirudin
IV and IM (only LMW)
Bile acid - binding resins
31. MOA of Bisphosphonates
Selective inhibitor of microtubule assembly
Streptokinase
Entacapone and Tolcapone
Inhibits osteoclast bone resorption
32. SE of CCB
Cholinesterase inhibitors
Constipation - edema - and headache
Hepatic toxicity
Nondepolarizing Neuromuscular Blockers
33. Scabicide organophosphate
L- asparaginase
Adenosine
Thyroid and steroid hormones
Malathion
34. DOC for paroxysmal supraventricular tachycardia; has high efficacy and short duration of action
Serotonin syndrome
Adenosine
Tamsulosin (Flomax)
Radioactive iodine
35. SE of these drugs include dependence - withdrawal syndrome - sedation - euphoria - respiratory depression nausea and vomiting - constipation - biliary spasm - increased ureteral and bladder tone - and reduction in uterine tone
Organic nitrites
Neutropenia and agranulocytosis
Estogens increase maternal TBG
Opioid Analgesics
36. Agent to treat torsades de pointes
Magnesium sulfate
Scotch tape technique and mebendazole
Etidronate
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
37. Lithium is associated with this congenital defect
Agranulocytosis
Caffeine
Cardiac anomalies and is contraindicated in pregnancy or lactation
Phentolamine
38. Class III antiarrhythmic that exhibits properties of all 4 classes
CNS toxicity
Trazodone
Amiodarone
Pralidoxime
39. Most common SE of fibrates
Nausea
Odansetron - granisetron
Cyanide toxicity treated with sodium thiosulfate
Clozapine
40. Benzodiazepines that are the most effective in the treatment of panic disorder
Alprazolam and Clonazepam
Carmustine (BCNU) and lomustine (CCNU)
Lithium
Infants - closed angle glaucoma - prostatic hypertrophy
41. Treatment of myasthenia gravis
Ipodate
Inhibit Cytochrome P450 3A4
Pyridostigmine
Fluphenazine and haloperidol
42. HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
Protease inhibitors
Cholinesterase inhibitors
Noncompetitive antagonist
TD50
43. Most common side effect of 1st generation antihistamines
B- blockers
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Buspirone
Sedation
44. Alpha 1 agonist toxicity
Hypertension
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Venlafaxine
Thrombocytopenia
45. SE of ergot alkaloids
Geriatrics due to its CNS (depression) effects
Alprostadil
Calcium channels
Hallucinations resembling psychosis
46. Triptan available in parenteral and nasal formulation
Halothane
Reduce aqueous secretion
Sumatriptan
Inhibit Na+/Cl - cotransport
47. Common side effect of Rifampin
Nephro and ototoxicity
Red urine discoloration
Affect calcium - potassium - and sodium channels
Sodium bicarbonate
48. Agent used for anemias associated with renal failure
Erythropoietin
Aldehyde dehydrogenase
Iodide salts
Rebound HTN - sedation - dry mouth
49. Short acting glucocorticoids
Caffeine
Cephalosporins
Cortisone and hydrocortisone (equivalent to cortisol)
Phase I
50. Antidote for arsenic - mercury - lead - and gold poisoning
Ipratropium
Autocoids
Dimercaprol
high doses