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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Inhaled anesthetic causes peripheral vasodilation
Lepirudin
Isoflurane
Desflurane
Barbiturates - phenytoin - carbamazepine - and rifampin
2. Presynaptic Alpha 2 agonist used in HTN - and acts centrally
Clonidine - and methyldopa
Ascending pathways
Acute intermittent porphyria
Severe hypertension
3. Specific pharmacokinetic characteristic of amiodarone
Ribavirin
Prolonged half - life - up to six weeks
5- flouracil (5- FU)
Tinnitus - GI bleeding
4. Reason benzos are used cautiously in pregnancy
Nevirapine - amprenavir
Buprenorphine
Ability to cross the placenta
Amiodarone
5. Toxic effect of anticancer drug can be lessened by rescue agents
Rescue therapy
Timolol (nonselective) - betaxolol (selective)
Indomethacin
Salmeterol
6. Antidote used for acetaminophen (APAP) toxicity
N- acetylcysteine (Mucomyst)
Rheumatic disease
Aspirin - metoprolol
Morphine and fentanyl
7. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
Haloperidol
Amiodarone
Cholinesterase inhibitors
Physostigmine
8. Interferes with activity of T- lymphocytes
Chlorpropamide
Hydroxychloroquine
Flumazenil
prolongs QT and PR interval
9. Pneumonic for beta receptors
Nortriptyline - Desipramine
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Nitrites
Ipratropium
10. Most commonly abused in health care professionals
Bupropion
Heroin - morphine - oxycodone - meperidine and fentanyl
Gynecomastia and hyperkalemia
Overdose of opioids
11. Loops lose and thiazide diuretics retain
Calcium
Serotonin syndrome
Chloramphenicol
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
12. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
Flumazenil
Prinzmetal's angina
NSAIDS
SSRI's - bupropion - and venlafaxine
13. Antidote for digoxin toxicity
Gingival hyperplasia
Block voltage - dependent sodium channels
Digibind
Acid reflux disease - duodenal ulcer and peptic ulcer disease
14. Antidote for salicylate intoxication
Alkalinize urine - dialysis
Additive CNS depression
Tolerance
Stevens - Johnson syndrome
15. Anti - estrogen used for estrogen receptor + breast cancer
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Fentanyl
Tamoxifen
Skeletal muscle tremor - tachycardia
16. Agent used to treat chronic gout by increasing uric acid secretion and excretion
Probenecid and sulfinpyrazone
Lepirudin
Propranolol
Phase I
17. COX 2 inhibitors should be used cautiously in pts with
Niacin
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Fluorocarbons and Industrial solvents
Pre - existing cardiac or renal disease
18. Inhibit angiotensin - converting enzyme (ACE)
Methotrexate
Barbiturates - phenytoin - carbamazepine - and rifampin
Drug induced Parkinsonism
ACE inhibitors
19. Beta 1 agonist toxicity
Cimetidine
Dobutamine and dopamine
Thiopental
Sinus tachycardia and serious arrhythmias
20. Nonselective alpha agonists that increases outflow - probably via the uveoscleral veins
Prilocaine
Epinephrine - dipivefrin
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Anterograde amnesia
21. Chronic orthostatic hypotension can be treated with
Testosterone
Midodrine
Interferon alpha
Dapsone - rifampin and clofazimine combination
22. SSRI less likely to cause a withdrawal syndrome
CNS toxicity
Ezetimibe (Zetia)
Thick ascending limb
Fluoxetine
23. Antidote for methotrexate toxicity
GLUT 2
Hepatotoxicity
Leucovorin
Point mutation
24. A hormone whose mechanism of action (MOA) utilizes intracellular receptors
Ipratropium
Aspirin - Nitrates - CCB - and Beta blockers
Thyroid and steroid hormones
Paclitaxel (taxol)
25. Concurrent use of fibrates and statins increases risk of
PTU
Irreversibly blocking cyclooxygenase
Rhabdomyolysis
Vitamin K or fresh frozen plasma
26. PTU (propylthiouracil) MOA
Dapsone - rifampin and clofazimine combination
Degradation of fibrin clots and are administered IV
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Hydroxychloroquine
27. Drug used supraventricular arrhythmias
Nesiritide (Natrecor)
Digoxin
Lupus - like syndrome
inhibits Na+/K+/2Cl - cotransport
28. Combined alpha and beta blocking agents that may have application in treatment of CHF
Nitroprusside
Nonselective Muscarinic Antagonists
Tamsulosin (Flomax)
Labetalol and carvedilol
29. Nitrate free intervals are needed due to
L- thyroxine (T4)
Tolerance
Xanthine oxidase
Calcium channels
30. What do delta cells in the pancreas produce?
Somatostatin
EOS
Dopamine
Increases concentration of Digoxin
31. Thiazolidinediones
Abstinence syndrome
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Hepatotoxicity
Metformin
32. Amphetamine agents
Therapeutic index
Dextroamphetamines and methamphetamine
Tinnitus - GI bleeding
Dipyridamole
33. SE of penicillamine
Reducing preload
Aztreonam
Estogens increase maternal TBG
Aplastic anemia and renal toxicity
34. Potassium sparing diuretics inhibit
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Cyproterone acetate
Epinephrine - dipivefrin
Na+/K+ exchange
35. 1st generation antihistamine that is least sedating
Aplastic anemia and renal toxicity
Chlorpheniramine or cyclizine
Sedation
Morphine - methadone - meperidine - and fentanyl
36. MOA of repaglinide
Work at early distal convoluted tubule
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Nitrous oxide
37. Thioamide agents used in hyperthyroidism
PGE1
Amphetamines
Parathion
Methimazole and propylthiouracil (PTU)
38. SE seen only in men with administration of ketoconazole
Tissue plasmin activator
Gynecomastia
Fexofenadine - loratadine - and cetirizine
Dobutamine
39. HMG CoA reductase inhibitors are contraindicated in
Antithrombin 3
Pregnancy
Respiratory failure
Hypercalcemia
40. SE of acetaminophen
Excessive CNS stimulation (seizures)
Hepatotoxicity
Arteries and veins
Vitamin D
41. Major drug interaction with Quinidine
Nephro and ototoxicity
Testosterone
Use in IgE mediated allergic reaction
Increases concentration of Digoxin
42. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
Aspirin - metoprolol
Levodopa
ED50
Tamoxifen
43. Toxicity of organophosphate:
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Phenytoin
Glucagon
Pancuronium
44. Inhaled anesthetic with a low blood/gas partition coefficient
Amantadine
Citalopram and its metabolite escitalopram
Nitrous oxide
Desflurane
45. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
Tamsulosin
Halothane and methoxyflurane
Delavirdine - efavirenz - and ribavirin
Amantadine
46. Prototypical drug is atropine
Nonselective Muscarinic Antagonists
Diazepam
Fludrocortisone and deoxycorticosterone
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
47. Opioids used in anesthesia
Glargine (Lantus) - detemir
Nifedipine
Morphine and fentanyl
Ketamine
48. MOA of quinolones
Skeletal muscle tremor - tachycardia
Bone marrow and teeth discoloration for children under 8 years of age
Succinylcholine
Inhibit DNA gyrase
49. Sulfonylurea Not recommended for elderly because of very long half life
Cholinesterase regenerators - pralidoxime
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Chlorpropamide
Morphine - methadone - meperidine - and fentanyl
50. IV Drug used Hypertensive Crisis
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Potassium channel blockers
Nitroprusside
GLUT 2