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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug used in Chagas disease
Urinary acidification and activated charcoal or continual nasogastric suction
Folic acid
Increasing sodium excretion and decreases arterial and venous tone
Nifurtimox
2. What do beta cells in the pancreas produce?
Bleeding
Insulin
Norepinephrine and serotonin
Levodopa
3. This beta blocker is highly lipid soluble and may account for side effects such as nightmares
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Streptomycin
6- mercaptopurine (6- MP)
Propranolol
4. Converted to more active form DHT by 5 alpha - reductase
Insulin release from pancreas by modifying K+ channels
Increasing afterload and tissue perfusion declines
Ferrous sulfate
Testosterone
5. Anti - seizure medication also used in the prevention of migraines
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Lepirudin
Valproic acid
Bone marrow and teeth discoloration for children under 8 years of age
6. NSAID that is used for acute condition - such as pre - op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
Hepatic
Ketoralac
Propoxyphene
Diphenoxylate - Loperamide
7. SE of minoxidil
Reduce inhibition - suppress anxiety - and produce relaxation
Procarbazine
Sedation
Hypertrichosis
8. Cause dizziness - tachycardia - hypotension - and flushing
Specificity
Ketanserin cyproheptadine - and phenoxybenzamine
Dry cough - hyperkalemia
Organic nitrites
9. Atypical antipsychotic causing high prolactin levels
Streptomycin
Risperidone
Marijuana
LFT's
10. 3 zones of adrenal cortex and their products
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Side - effect profile and prior pt response
B- blockers
Esmolol
11. Anti - biotic frequently used for chronic UTI prophylaxis
sulfamethoxazole/ trimethoprim
Log - kill hypothesis
Adalimumab - infliximab and etanercept
Thiopental
12. Non - benzodiazepine used for sleep
Adrenal suppression and weaning slowly - respectively
Haloperidol
None
Zolpidem
13. SE of colchicine
Nadolol
Kidney and liver toxicity - diarrhea
Sulfonamides
Hepatic toxicity
14. SE for Lamotrigine
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Stevens - Johnson syndrome
Epinephrine
Estrogen (HRT- Hormone replacement therapy)
15. Endogenous insulin contains
Glucagon
Aplastic anemia and acute hepatic failure
Normal C- peptide
Acebutolol and atenolol
16. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)
Minocycline
Acyclovir; incorporated into viral DNA and chain termination
GI bleeding
Entacapone and Tolcapone
17. TCA used in obsessive compulsive disorder (OCD) - most significant of TCA's for risk of seizure - weight gain - and neuropsychiatric signs and symptoms
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Clomipramine
Desmopressin (DDAVP)
Liver enzyme INDUCTION
18. Common SE of tamoxifen and raloxifene
Cholinesterase inhibitors
Nefazodone
Nitroprusside
Hot flashes
19. Meningitis prophylaxis in exposed patients
Theophylline
Rifampin
Ceftriaxone or cefuroxime
Cimetidine
20. Used to treat patients exposed to insecticides such as parathion
Bradykinin
Drug induced Parkinsonism
Aspirin
Pralidoxime - atropine
21. Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Flumazenil
Megaloblastic anemia
Propoxyphene
22. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation
Nevirapine - amprenavir
Protamine sulfate
Pralidoxime - atropine
Fluorocarbons and Industrial solvents
23. Example of three antidepressants that are indicated for obsessive compulsive disorder
Volume of distribution (VD)
Autocoids
Clomipramine - fluoxetine and fluvoxamine
high doses
24. Beta - blockers should be used cautiously in
Carbidopa
Potassium channel blockers
Decreased micro and macro vascular disease
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
25. Monitoring parameter to obtain before initiation of STATINS
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26. Agents used in Tourette's dx
Inhibit Cytochrome P450 3A4
Geriatrics due to its CNS (depression) effects
Clomipramine - fluoxetine and fluvoxamine
Haloperidol or pimozide
27. Effective in preventing TIA's
Vincristine
Clopidogrel and ticlopidine
Full agonist
Arginine
28. Barbiturate used for the induction of anesthesia
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Bile acid - binding resins
Marijuana
Thiopental
29. H2 blocker that causes the most interactions with other drugs
Retinal destruction and dermatitis
Cimetidine
Nortriptyline - Desipramine
Inhibit Na+/Cl - cotransport
30. Side effect of sotalol
Methoxyflurane
Thrombocytopenia
prolongs QT and PR interval
Monamine oxidase inhibitors
31. Neurotoxicity with isoniazid (INH) prevented by
Propranolol
Olanzapine
6- mercaptopurine (6- MP)
Administration of Vit. B6 (pyridoxine)
32. Loops lose and thiazide diuretics retain
Inhibit dihydropteroate synthase
Gynecomastia and hyperkalemia
Hypertrichosis
Calcium
33. SE of lithium
Metronidazole
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Morphine - methadone - meperidine - and fentanyl
Cyanide toxicity treated with sodium thiosulfate
34. Reversal of blockade by neuromuscular blockers
NSAIDS
Spironolactone
Clozapine
Cholinesterase inhibitors
35. Prevents thrombosis in patients with artificial heart valve
Dipyridamole
Naltrexone
Acarbose - miglitol
Gynecomastia hyperkalemia - and impotence
36. Condition will result from in combination of MAOI with tyramine containing foods (ex. wine - cheese - and pickled meats)
Sodium channel blockade
Hypertensive crisis
Verapamil
Glucocorticoids
37. Warfarin is contraindicated in
Amiodarone
Pregnancy
Benztropine
Glucuronate - acetic acid - and glutathione sulfate
38. Drug elimination with a constant amount metabolized regardless of drug concentration
nephro and ototoxicity
Zero order kinetics
Propofol
sulfamethoxazole/ trimethoprim
39. Use of this opioid with MAOI can lead to hyperpyrexic coma - and with SSRI's can lead to serotonin syndrome
Rebound HTN - sedation - dry mouth
Meperidine
Most are thought to act at GABA- A receptor - chloride channel
Aspirin - metoprolol
40. Moderate opioid agonists
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Esmolol
Mast cell stabilizer
Codeine - hydrocodone - and oxycodone
41. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively
Phenytoin
NSAIDS
Leuprolide
Angiotensin receptor
42. Two toxicities of aminoglycosides
Low therapeutic index
nephro and ototoxicity
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Nadolol
43. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
Mechlorethamine
Levodopa
First order kinetics
Kidneys
44. Beta 1 agonists used in acute CHF
Infliximab
Malathion
Adrenal suppression and weaning slowly - respectively
Dobutamine and dopamine
45. Antidote used for methanol and ethylene glycol
Megaloblastic anemia
Ethanol or fomepizole
Rhabdomyolysis and Hepatotoxicity
Increased thromboembolic events
46. Agent used for neurological deficits in megaloblastic anemia
Point mutation
Carboplatin
EOS
Vitamin B12
47. Agents used in Huntington's Disease
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Mirtazapine
Zafirlukast and montelukast
Pregnancy
48. Anti - psychotic not shown to cause tardive dyskinesia
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Scotch tape technique and mebendazole
Pindolol and acebutolol
Clozapine
49. Interaction with this drug requires dose reduction of 6- MP
Esmolol
Digibind
Glucagon
Allopurinol
50. Opioid that can be given PO - by epidural - and IV - which helps to relieve the dyspnea of pulmonary edema
Dipyridamole
Vitamin K and Fresh frozen plasma (FFP)
Amiodarone
Morphine