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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Relates the amount of drug in the body to the plasma concentration
Volume of distribution (VD)
Letrozole - anastrozole
Agranulocytosis
Epinephrine
2. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
Demeclocycline
Dry cough
Lorazepam - oxazepam - and temazepam
Flumazenil
3. Arterial vasodilator that works by opening K+ channels
Aspirin
Full agonist
Inhibit Na+/Cl - cotransport
Minoxidil
4. Converted to more active form DHT by 5 alpha - reductase
Testosterone
Valproic acid and Phenytoin
Inhibit Cytochrome P450 3A4
Ototoxicity
5. Mast cells to reduce release of hisamine and inflammatory mediators
Most are thought to act at GABA- A receptor - chloride channel
Pamidronate - zoledronate - ibandronate
St. Anthony's Fire
Epinephrine
6. Other side effects of Quinidine
Codeine - hydrocodone - and oxycodone
Diphendydramine
Sulfasalazine
Thrombocytopenic purpura - and CINCHONISM
7. SE of these drugs include dependence - withdrawal syndrome - sedation - euphoria - respiratory depression nausea and vomiting - constipation - biliary spasm - increased ureteral and bladder tone - and reduction in uterine tone
Thrombocytopenia
Opioid Analgesics
Sulfonamides
Desflurane
8. Alpha 1selective blockers
Carmustine (BCNU) and lomustine (CCNU)
Hyperuricemia - hypokalemia and ototoxicity
Dobutamine and dopamine
Prazosin - terazosin and doxazosin (- AZOSIN ending)
9. Except for these agents all SSRI have significant inhibition of CytP450 enzymes
Leuprolide
Nevirapine - amprenavir
Protamine sulfate
Citalopram and its metabolite escitalopram
10. DOC to treat chemo - induced nausea and vomiting
Thyroid and steroid hormones
Hypokalemia
Odansetron
Buspirone
11. Laboratory value required to be monitored for patients on valproic acid
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12. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
Muscarinic blockers
Flumazenil
Amrinone and milrinone
Sermorelin
13. Thiazolidinediones
Nitroprusside
Amoxicillin
Antithrombin 3
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
14. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension
Propofol
G- CSF (filgrastim) and GM- CSF (sargramostim)
Aspirin - metoprolol
Delavirdine - efavirenz - and ribavirin
15. Agents that block L- type calcium channel
Calcium channel blockers
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Atropine
Organic nitrites
16. Reversal of blockade by neuromuscular blockers
Olanzapine - aripiprazole - and sertindole
Cholinesterase inhibitors
Folic acid
sodium polystyrene sulfonate (Kayexalate)
17. Treatment of withdrawal syndrome involves
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
Temazpam - trizolam - flurazepam
ED50
Ganirelix
18. Captopril and enalapril (- OPRIL ending) are
ACE inhibitors
Cyproheptadine
Fentanyl
GABA- related targets
19. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism
Iodide salts
Thiopental
Octreotide
Zolpidem - zaleplon
20. Cheap wide spectrum antibiotic DOC for otitis media
Amoxicillin
Vitamin K or fresh frozen plasma
NSAIDS
Niacin
21. TCA used in chronic pain - enuresis - and ADD
Imipramine
Valproic acid - carbamazepine - phenytoin and gabapentin
Dantrolene
Clozapine
22. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Epinephrine
Valproic acid - carbamazepine - phenytoin and gabapentin
Vitamin K and Fresh frozen plasma (FFP)
Corticosteroids
23. Secondary amines that have less sedation and more excitation effect
Tetracaine and bupivacaine
Nortriptyline - Desipramine
Codeine - hydrocodone - and oxycodone
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
24. Agents used in treatment of carcinoid tumor
Ketanserin cyproheptadine - and phenoxybenzamine
Halothane and methoxyflurane
Scopolamine - meclizine
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
25. Most common side effect of 1st generation antihistamines
Clozapine
Rescue therapy
GABA- related targets
Sedation
26. Anti - progesterone used as abortifacient
Betamethasone and dexamethasone
Mifepristone (RU-486)
Increasing sodium excretion and decreases arterial and venous tone
Midazolam
27. Treatment of myasthenia gravis
Presynaptic mu - delta - and kappa receptors
Pyridostigmine
Naloxone
Bleeding
28. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Acetazolamide
Affect calcium - potassium - and sodium channels
Thioridazine
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
29. IV barbiturate used as a pre - op anesthetic
Thiopental
Deferoxamine
Cevimeline
Methotrexate
30. '5HT-1d agonist used for migraine headaches '
Sumatriptan - naratriptan - and rizatriptan
Beta1 agonists
Toremifene (Fareston)
Work at early distal convoluted tubule
31. Agent having no effect on D2 receptors - blocks D4 - reserved for resistant schizophrenia - and can cause fatal agranulocytosis
Potential for development of Reye's syndrome
Clozapine
L- thyroxine (T4)
Cholinesterase regenerators - pralidoxime
32. SE of clonidine
Amantadine
Rebound HTN - sedation - dry mouth
ED50
sulfamethoxazole/ trimethoprim
33. Proteins that prevent action of tumor necrosis factor alpha (TNF- alpha)
Rebound HTN - sedation - dry mouth
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Adalimumab - infliximab and etanercept
Sotalol
34. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure
Zolpidem - zaleplon
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Cyproheptadine
Venlafaxine
35. Disease caused by excess ergot alkaloids
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36. SE of AGI's
Rheumatic disease
Alprazolam
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Rhabdomyolysis
37. Aromatase inhibitor used in breast cancer
Glucagon
Letrozole - anastrozole
Infants
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
38. Agent used to treat chronic gout by increasing uric acid secretion and excretion
Cocaine
Probenecid and sulfinpyrazone
IV administration
Postsynaptic Mu receptors
39. Drugs of choice for generalized tonic - clonic and partial seizures
Efficacy
Sotalol
Midazolam
Valproic acid and Phenytoin
40. Agent used for acute muscle spasm
Bleeding
Cyclobenzaprine
Abciximab - tirofiban and eptifibatide
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
41. Strong opioid agonists
Side - effect profile and prior pt response
Morphine - methadone - meperidine - and fentanyl
Acebutolol - atenolol - esmolol - metoprolol
Bleeding
42. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Glucocorticoids
Pregnancy
Octreotide
Minimum alveolar anesthetic concentration (MAC)
43. Drug causing depletion of substance P (vasodilator)
Vasodilation
Capsaicin
Bleeding
Vitamin K and Fresh frozen plasma (FFP)
44. Antiarrhythmic that exhibits Class II and III properties
Prolonged half - life - up to six weeks
None
Sotalol
Maprotiline
45. When the rate of drug input equals the rate of drug elimination
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Infliximab
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
Steady state
46. Beta 1 agonists used in acute CHF
Ethinyl estradiol and mestranol
Dobutamine and dopamine
Morphine
Dantrolene
47. Antiplatelet drug reserved for patients allergic to aspirin
Methotrexate
Tolerance
Atropine - homatropine - C1208 tropicamide
Ticlopidine
48. Antidote used for organophosphate/anticholinesterase poisoning
Potential for development of Reye's syndrome
Atropine - pralidoxime (2- PAM)
Carvedilol
Cyclobenzaprine
49. Important in synthesis of glucose to glycogen in the liver
Liver toxicity
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
GLUT 2
Increasing afterload and tissue perfusion declines
50. Barbiturates may precipitate this hematologic condition
First order kinetics
Calcitonin (salmon prep)
Acute intermittent porphyria
Cyproheptadine