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USMLE/COMLEX Step 1 Pharmacology One Liners
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Subjects
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health-sciences
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usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
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study here
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. These agents are congeners of Amphetamine
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2. Aspirin is contraindicated in children with viral infection
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3. These LA's have surface activity
Calcitonin (salmon prep)
Cocaine and benzocaine
Clomipramine - fluoxetine and fluvoxamine
Uterine contractions
4. SE of penicillamine
Ipratropium
Aplastic anemia and renal toxicity
Hydroxychloroquine
Diazepam
5. Agent effective in physiologic and essential tremor
Deferoxamine
Leuprolide
Propranolol
Tricyclic antidepressants (TCA)
6. Losartan and valsartan block
Angiotensin receptor
Neutropenia and agranulocytosis
Pyridostigmine
Nitrous oxide
7. DOC for paroxysmal supraventricular tachycardia (PSVT)
Adenosine
Acute intermittent porphyria
Sedation
Pregnancy
8. Antidote used for warfarin toxicity
Vitamin K and Fresh frozen plasma (FFP)
Clopidogrel and ticlopidine
Thioridazine
Raloxifene (SERM- selective estrogen receptor modulator)
9. Common SE of spironolactone
Phenoxybenzamine
Odansetron
Gynecomastia and hyperkalemia
Agranulocytosis
10. Drugs of choice for generalized tonic - clonic and partial seizures
Desmopressin (DDAVP)
Cocaine
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Valproic acid and Phenytoin
11. Microtubule inhibitor that causes peripheral neuropathy - foot drop (eg. ataxia) - and 'pins and needles' sensation
Odansetron - granisetron
Amantadine
Vincristine
Angiotensin receptor
12. Antiarrhythmic that exhibits Class II and III properties
Calcitonin (salmon prep)
Methadone - followed by slow dose reduction
Sotalol
Dopamine
13. Benzodiazepines that are the most effective in the treatment of panic disorder
Folic acid
Alprazolam and Clonazepam
Cimetidine
Deferoxamine
14. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction
Prednisone
Prostaglandin PGF2a
Meperidine
Didanosine
15. Oral contraceptive available in a transdermal patch
Clearance (CL)
Tolerance
Ethanol
Ortho - Evra
16. Neurotransmitters affected by the action of antidepressants
sodium polystyrene sulfonate (Kayexalate)
PCP
pregnancy and with K+
Norepinephrine and serotonin
17. Drugs available in combination with metformin
Hyperuricemia - hypokalemia and hyperglycemia
Clonidine - and methyldopa
Glyburide - glipizide - and rosiglitazone
Acid reflux disease - duodenal ulcer and peptic ulcer disease
18. Drugs that can be used for infantile spasms
Agranulocytosis
Pilocarpine
Terbutaline
Corticosteroids
19. Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and prophylaxis in women with risk factors for breast cancer
Raloxifene
Codeine - hydrocodone - and oxycodone
Naloxone
Stevens - Johnson syndrome
20. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
lispro insulin - aspart insulin - glulisine insulin
Vancomycin
Depression of medullary and cardiovascular centers
Tamsulosin
21. Prolonged exposure to this inhaled anesthetic may lead to megaloblastic anemia
'On - off - phenomenon'
IV and IM (only LMW)
Fentanyl
Nitrous oxide
22. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction
Nesiritide (BNP)
Labetalol and carvedilol
Morphine and fentanyl
Pilocarpine - carbachol - physostigmine
23. Antidepressant associated with neuroleptic malignant syndrome
Valproic acid
Amoxapine
Pregnancy
Metronidazole
24. Specific pharmacokinetic characteristic of amiodarone
Aspirin
Ganciclovir - zidovudine - saquinavir - and interferon
Prolonged half - life - up to six weeks
Ototoxicity
25. Benzodiazepines used to promote sleep
Propranolol
Temazpam - trizolam - flurazepam
Acarbose
Streptokinase
26. Antiglaucoma organophosphate
Seizures
Fentanyl
Echothiophate
PGI2 (epoprostenol)
27. Similar to clonidine and may cause hypotension
Tizanidine
Cortisone and hydrocortisone (equivalent to cortisol)
Muscarinic blockers
Benztropine
28. SE of OCs
Amiodarone
Propoxyphene
Increased thromboembolic events
Rifampin
29. Ability to produce less than 100% of the response
Partial agonist
Tertiary amines
Heparin
Nortriptyline - Desipramine
30. Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
Reduce aqueous secretion
Etidronate
Oral and transdermal forms of nitroglycerin
Sulfasalazine
31. Used for hairy cell leukemia; it stimulates NK cells
Interferon alpha
Valproic acid - carbamazepine - phenytoin and gabapentin
Leuprolide
B- blockers
32. What do beta cells in the pancreas produce?
Probenecid and sulfinpyrazone
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Interferon alpha
Insulin
33. PTU (propylthiouracil) MOA
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Odansetron - granisetron
Mivacurium
34. Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)
Olanzapine - aripiprazole - and sertindole
Combination oral contraceptives (OC)
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Sulfonamides
35. Drug that causes gray baby syndrome and aplastic anemia
Nondepolarizing Neuromuscular Blockers
Retinal destruction and dermatitis
Chloramphenicol
High therapeutic index
36. Digoxin toxicity can be precipitated by
Terfenadine and astemizole (have been removed from the market)
Tissue plasmin activator
Hypokalemia
Calcium
37. Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release
GFR
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Mannitol
Presynaptic mu - delta - and kappa receptors
38. Cephalosporins able to cross the BBB
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Epinephrine
Carmustine (BCNU) and lomustine (CCNU)
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
39. MOA of neuroleptics
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Dopamine blockade
Sumatriptan - naratriptan - and rizatriptan
prolongs QT and PR interval
40. Anti - viral with a dose limiting toxicity of pancreatitis
Methoxyflurane
Phentolamine
Angiotensin receptor
Didanosine
41. Causes bone marrow suppression
Ketoralac
Acebutolol and atenolol
Methotrexate
Esmolol
42. MOA for Valproic acid at high doses
Affect calcium - potassium - and sodium channels
Naloxone
Inhibition of protein synthesis at the 50s subunit of ribosome
Methimazole and propylthiouracil (PTU)
43. Toxic effect of anticancer drug can be lessened by rescue agents
Radioactive iodine
Rescue therapy
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Ipratropium
44. This is the drug of choice for anaphylactic shock
Class IC (flecainide - propafenone - moricizine)
Prolongs QT interval
Depression of medullary and cardiovascular centers
Epinephrine
45. Mast cells to reduce release of hisamine and inflammatory mediators
Geriatrics due to its CNS (depression) effects
Calcium
Epinephrine
Pilocarpine
46. Fibrates are contraindicated in
Pregnancy
Topical mupirocin (Bactroban)
Norepinephrine and serotonin
Decreases protein synthesis by inhibiting 30S ribosome
47. Carbonic anhydrase inhibitor
Valproic acid
Rebound HTN - sedation - dry mouth
Acetazolamide
Hypoglycemia
48. Strength of interaction between drug and its receptor
Nondepolarizing Neuromuscular Blockers
Kidney and liver toxicity - diarrhea
Tolerance
Affinity
49. Antidepressant also used for sleep that causes priapism
Acebutolol - atenolol - esmolol - metoprolol
Trazodone
Epinephrine
Excessive CNS stimulation (seizures)
50. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
Raloxifene
Haloperidol
Ketoconazole
Combination oral contraceptives (OC)
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