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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug causes teeth discoloration






2. Anti - seizure agent that induces formation of liver drug - metabolism enzymes - is teratogen and can cause craniofacial anomalies and spina bifida






3. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects






4. Antidote to reverse actions of heparin






5. Antidote for digoxin toxicity






6. Interaction with this drug requires dose reduction of 6- MP






7. Activation of these receptors open K+ ion channels to cause membrane hyperpolarization






8. Similar to clonidine and may cause hypotension






9. Effective in preventing TIA's






10. Median effective dose required for an effect in 50% of the population






11. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects






12. Toxic effect of anticancer drug can be lessened by rescue agents






13. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors






14. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep






15. Tubocurarine is the prototype - pancuronium - atracurium - vecuronium are newer short acting agent - produce competitive block at end plate nicotinic receptor - causing flaccid paralysis






16. Except for these agents all SSRI have significant inhibition of CytP450 enzymes






17. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents






18. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension






19. MOA of nesiritide






20. Important in synthesis of glucose to glycogen in the liver






21. Beta blockers work in CHF by






22. MOA of Bisphosphonates






23. Drug used in cancer therapy causes Cushing - like symptoms






24. Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy - it does not cause cycloplegia






25. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses






26. Prostaglandin used in the treatment of impotence






27. Benzodiazepines used to promote sleep






28. Window between therapeutic effect and toxic effect






29. Side effects seen with tricyclic antidepressants






30. Concurrent use of fibrates and statins increases risk of






31. Inversely related to potency of anesthetics






32. Antipsychotics that reduce positive symptoms only






33. The most important sign of withdrawal syndrome






34. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration






35. Treatment of atropine overdose and glaucoma (because lipid soluable). Enters the CNS rapidly and has a stimulant effect - which may lead to convulsions






36. Drug is used with testosterone for male fertility






37. SE for ticlopidine






38. Drug of choice for leprosy






39. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation






40. Antidote used for acetaminophen (APAP) toxicity






41. SE of phenytoin






42. Class of drugs with ability to decrease the maximal response to an agonist






43. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal






44. Drug causing depletion of substance P (vasodilator)






45. Used especially in postmenopausal women - dosage should be 1500 mg






46. Agent that is teratogen and causes a fetal syndrome






47. SE of heparin






48. Barbiturate used for the induction of anesthesia






49. Nonselective alpha agonists that increases outflow - probably via the uveoscleral veins






50. 5HT-3 antagonist used in chemotherapeutic induced emesis