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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Cholestyramine and colestipol are
Bile acid - binding resins
Diazepam
Cocaine
B- blockers
2. MOA of tetracycline
Increased thromboembolic events
Parathion
Decreases protein synthesis by inhibiting 30S ribosome
Minocycline
3. Use of this opioid with MAOI can lead to hyperpyrexic coma - and with SSRI's can lead to serotonin syndrome
Albuterol
Meperidine
Nitrous oxide
Selegiline
4. Names of three bisphosphonates available IV
Pamidronate - zoledronate - ibandronate
inhibits Na+/K+/2Cl - cotransport
Buspirone
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
5. Peptide causing increased capillary permeability and edema
Diazepam
Bradykinin and histamine
Ketamine
Aspirin
6. Anabolic steroid that has potential for abuse
Minimum alveolar anesthetic concentration (MAC)
Dantrolene
Nandrolone - oxymetholone - and oxandrolone
Clindamycin
7. Antidote for methotrexate toxicity
Monamine oxidase inhibitors
Long acting cholinesterase inhibitors
Leucovorin
Normal C- peptide
8. Slightly increased risk of breast cancer - endometrial cancer - heart disease (questionable) - has beneficial effects on bone loss
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Estrogen
Metformin
Aspirin - metoprolol
9. Nitrate used for acute anginal attacks
Ketoconazole
Low therapeutic index
Heroin - morphine - oxycodone - meperidine and fentanyl
Nitroglycerin sublingual tablets
10. Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and prophylaxis in women with risk factors for breast cancer
hydroxyzine (Atarax)
Raloxifene
Pralidoxime - atropine
Thrombocytopenia
11. Major SE of zileuton
Gynecomastia
Liver toxicity
NO - chloroform - and diethyl ether
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
12. Interaction with this drug requires dose reduction of 6- MP
Allopurinol
Ferrous sulfate
Calcium channel blockers
Nephrotoxicity
13. Condition will result from in combination of MAOI with tyramine containing foods (ex. wine - cheese - and pickled meats)
Bromocriptine
Interferon alpha
Hypertensive crisis
B- blockers
14. Nonselective alpha - blocking drug - long acting and irreversible - and used to treat pheochromocytoma. Blocks 5- HT - so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis
Little C- peptide
Combination oral contraceptives (OC)
Phenoxybenzamine
Nesiritide (Natrecor)
15. Organophosphate anthelmintic agent with long DOA
Metrifonate
Valproic acid
Repaglinide
Pramipexole and ropinirole
16. SE of methyldopa
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17. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration
inhibit phospholipase A2
Nitrous oxide
Infants
Cosyntropin
18. Benzodiazepines that are the most effective in the treatment of panic disorder
Alprazolam and Clonazepam
Timolol
Older antipsychotic agents - D2 receptors
Miosis and constipation
19. MOA of NSAIDS
Torsades de pointes
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
Competitive antagonist
Flumazenil
20. Second generation sulfonylurea
Glyburide - glipizide - glimepiride - etc.
Tertiary amines
Metronidazole
Epinephrine
21. Ergot alkaloid used as an illicit drug
Acute intermittent porphyria
Hypertension
L- thyroxine (T4)
LSD
22. These agents decrease blood flow or increase blood pressure - are local decongestants - and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion
Alpha1 agonists
Point mutation
Cytomel
NSAIDS
23. Anti - malarial drug used in rheumatoid arthritis (RA)
Chlorpropamide
Bleomycin
Dextromethorphan - Codeine
Hydroxychloroquine
24. Anticoagulant of choice in pregnancy
Labetalol and carvedilol
Dextromethorphan - Codeine
Heparin
Tamoxifen
25. Loops lose and thiazide diuretics retain
Warfarin (PT)
Sulfonamides
Calcium
Cytomel
26. Anti - biotic frequently used for chronic UTI prophylaxis
Caffeine
Maprotiline
Meperidine
sulfamethoxazole/ trimethoprim
27. Antidote for salicylate intoxication
Alkalinize urine - dialysis
Nortriptyline - Desipramine
Neuromuscular blocking drugs
Bupropion
28. Only direct acting agent that is very lipid soluble and used in glaucoma
Cefixime (3rd) generation
Olanzapine - aripiprazole - and sertindole
Pilocarpine
Ketoralac
29. Life threatening cardiac event that prolong QT leads to
Ceftriaxone
Torsades de pointes
Zileuton
Betamethasone and dexamethasone
30. Tolerance to all effects of opioid agonists can develop except
Desmopressin (DDAVP)
Erythromycin
Amrinone and milrinone
Miosis and constipation
31. Routes of administration of heparin
CNS stimulation; GI upset
Glucuronate - acetic acid - and glutathione sulfate
IV and IM (only LMW)
Dipyridamole
32. Anti - microbials that cause hemolysis in G6PD- deficient patients
Sulfonamides
Venlafaxine
Thrombocytopenia
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
33. ADH agonist used for pituitary diabetes insipidus
Desmopressin (DDAVP)
Bind ergosterol in fungal cell membrane
Full agonist
Disulfiram
34. Anemia caused by trimethoprim
Insulin
Prinzmetal's angina
Desmopressin (DDAVP)
Megaloblastic anemia
35. ACTH analog used for diagnosis of patients with corticosteroid abnormality
Cosyntropin
Thiopental
Anterograde amnesia
EOS
36. SE of clonidine
Citalopram and its metabolite escitalopram
Repaglinide
Nitroprusside
Rebound HTN - sedation - dry mouth
37. Thrombolytics are used for
Hyperkalemia
Dexrazoxane
Pulmonary embolism and DVT
Nifurtimox
38. SE of nitrates
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Radioactive iodine
Therapeutic index
39. The selective agents loose their selectivity at
Aminocaproic acid
Dapsone - rifampin and clofazimine combination
Cocaine
high doses
40. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine
Sodium channel blockade
Flunitrazepam (rohypnol)
Succinylcholine
Raloxifene
41. Agent which stimulates cardiac contractile force more than rate with little effect on total peripheral resistance
Folic acid
Dobutamine
Gastric ulcers and GI Bleeding
Mast cell stabilizer
42. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Ethanol or fomepizole
Valproic acid - carbamazepine - phenytoin and gabapentin
SEVERE myelosuppression
inhibit phospholipase A2
43. Local anesthetic with vasoconstrictive property - favored for head - neck - and pharyngeal surgery
Cocaine
Rebound HTN - sedation - dry mouth
Sermorelin
Bradykinin and histamine
44. Anti - seizure medication also used in the prevention of migraines
Cholinesterase inhibitors
Valproic acid
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Benzodiazepines and calcium channel blockers
45. Hormone inhibiting prolactin release
Cardiac anomalies and is contraindicated in pregnancy or lactation
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Streptokinase
Dopamine
46. Antidepressants with no effect on BP - no sedation
Hepatic toxicity
SSRIs
N- acetylcysteine (Mucomyst)
nephro and ototoxicity
47. Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis
Buspirone
Desmopressin (DDAVP)
Ezetimibe (Zetia)
Propofol
48. Antidote for arsenic - mercury - lead - and gold poisoning
Dimercaprol
Thioridazine
CNS toxicity
Alpha1 agonists
49. Agent that is a partial agonist for the 5- HT1A receptor
Disulfiram - like reaction
Vitamin D
Dopamine
Buspirone
50. MOA of nitrates
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Atracurium
Amitriptyline
You have 1 heart (Beta 1) and 2 lungs (Beta 2)