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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug notorious for causing pseudomembranous colitis






2. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress






3. Interferes with activity of T- lymphocytes






4. Pneumonic for beta receptors






5. SE of beta blockers






6. Drugs of choice for generalized tonic - clonic and partial seizures






7. Biguanide






8. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis






9. Structurally related to acetylcholine - used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation






10. Non - steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy






11. Antivirals associated with neutropenia






12. Strength of interaction between drug and its receptor






13. The selective agents loose their selectivity at






14. Primary endogenous substrate for Nitric Oxidase Synthase






15. Beta blockers are used for which type of anginal attack






16. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate






17. Used intranasally and decreases bone resorption






18. This beta blocker is the longest acting






19. Life threatening cardiac event that prolong QT leads to






20. Pneumonic for 3 zones of adrenal cortex






21. Drug used in cancer therapy causes Cushing - like symptoms






22. Amount of drug necessary to elicit a biologic effect; refers to the drug's strength






23. For rebound HTN from rapid clonidine withdrawal






24. These LA's have surface activity






25. Treatment of myasthenia gravis






26. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property






27. MOA of general anesthetics






28. Most inhaled anesthetics SE






29. H2 blocker that causes the most interactions with other drugs






30. During Phase I these agents worsen muscle paralysis by succinylcholine - but during phase II they reverse the blockade produced by succinylcholine






31. Drug causes teeth discoloration






32. MOA of drug or foods (grapefruit juice) that increase statin effect






33. Treatment of motion sickness






34. Antiprogestin used as potent antagonist of GC receptor






35. Neurologic SE of benzodiazepines






36. Antidote for tissue plasminogen activator (t - PA) - streptokinase






37. Amino acid derivative - active as an insulin secretagogue






38. Agent used for megaloblastic anemia (but does Not reverse neurologic symptoms) and decrease neural tube defects during pregnancy






39. Reason benzos are used cautiously in pregnancy






40. Causes bone marrow suppression






41. Except for these agents all SSRI have significant inhibition of CytP450 enzymes






42. Dose which is lethal to 50% of the population






43. Opioids used in anesthesia






44. SE of ergot alkaloids






45. Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs






46. Metronidazole SE if given with alcohol






47. Aspirin reduces mortality in unstable angina by






48. Beta 1 agonists used in acute CHF






49. Enhances dopaminergic neurotransmission SE's include CNS excitation - acute toxic psychosis and livedo reticularis






50. Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)