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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug used in exoerythrocytic cycle of malaria
Primaquine
Infants
Iron deiodinates thyroxine
Toremifene (Fareston)
2. SE of spironolactone
Estrogen
Reduce aqueous secretion
Gynecomastia hyperkalemia - and impotence
Insulin
3. Mineralocorticoids
Letrozole - anastrozole
DOM - STP - MDA - and MDMA 'ecstasy'
Chlorpropamide
Fludrocortisone and deoxycorticosterone
4. Atypical antipsychotic causing high prolactin levels
Magnesium sulfate
Risperidone
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Protamine sulfate
5. Rapid acting insulins that do not self - aggregate
Aspirin
lispro insulin - aspart insulin - glulisine insulin
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Full agonist
6. This is the drug of choice for anaphylactic shock
Epinephrine
Drug induced Parkinsonism
Minoxidil
Rheumatic disease
7. Toxicity of anticholinergics
Reducing progression of heart failure (never use in acute heart failure)
Nondepolarizing type antagonists
Minocycline
block SLUD (salivation - lacrimation - urination - defecation
8. The ratio of the rate of elimination of a drug to its plasma concentration
Clearance (CL)
Glucagon
Phenoxybenzamine
Depression of medullary and cardiovascular centers
9. Antidote for hyperkalemia
sodium polystyrene sulfonate (Kayexalate)
Disulfiram
Dry cough - hyperkalemia
Administration of Vit. B6 (pyridoxine)
10. Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons
Acarbose - miglitol
Inhibit Cytochrome P450 3A4
Fentanyl
Ascending pathways
11. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Cartilage damage
Amoxicillin
Valproic acid
Adrenal suppression and weaning slowly - respectively
12. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Cholinesterase regenerators - pralidoxime
Ezetimibe (Zetia)
Phenylephrine
Naloxone (IV) - naltrexone (PO)
13. Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso - enzyme.
Terfenadine and astemizole (have been removed from the market)
Presynaptic mu - delta - and kappa receptors
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
14. Class III antiarrhythmic that exhibits properties of all 4 classes
Steady state
Thrombocytopenia
Amiodarone
Lispro (Humalog) - aspart - glulisine
15. Mast cells to reduce release of hisamine and inflammatory mediators
Bromocriptine
Amitriptyline
Epinephrine
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
16. Benzodiazepine used for anxiety
Pregnancy
Metronidazole
Alprazolam
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
17. Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage - cardiac arrhythmias - and myocardial infarction
Halothane
Degradation of fibrin clots and are administered IV
Cocaine
100% O2 and hyperbaric O2
18. SE of OCs
Aspirin - Nitrates - CCB - and Beta blockers
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Fexofenadine - loratadine - and cetirizine
Increased thromboembolic events
19. Nonselective alpha - blocking drug - short acting and reversible - used for rebound HTN from rapid clonidine withdrawal - and Raynaud's phenomena
Propofol
Radioactive iodine
Pulse therapy
Phentolamine
20. DOC for herpes and its MOA
Ethinyl estradiol and mestranol
Acyclovir; incorporated into viral DNA and chain termination
Methimazole and propylthiouracil (PTU)
Levodopa
21. Benzodiazepines used to promote sleep
LFT's
Increasing afterload and tissue perfusion declines
Venlafaxine
Temazpam - trizolam - flurazepam
22. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
6- mercaptopurine (6- MP)
Severe hypertension
Bleomycin
Chemical esophagitis
23. Generation of antihistamine that has the most CNS effects
Aspirin
First generation due to being more lipid - soluble
Calcium
Cyproterone acetate
24. Very rapid acting insulin - having fastest onset and shortest duration of action
Acetazolamide
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Lispro (Humalog) - aspart - glulisine
Midazolam
25. Non - benzodiazepine used as an anxiolytic
Buspirone
Diphenoxylate - Loperamide
6- mercaptopurine (6- MP)
Aplastic anemia and acute hepatic failure
26. Major SE of zileuton
Miosis and constipation
Midazolam
Liver toxicity
PGE1
27. Agent which stimulates cardiac contractile force more than rate with little effect on total peripheral resistance
Dobutamine
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
Ethosuximide and valproic acid
Dapsone - rifampin and clofazimine combination
28. Long acting glucocorticoids
Methimazole and propylthiouracil (PTU)
Mifepristone (RU-486)
Liver toxicity
Betamethasone and dexamethasone
29. Non ergot agents used as first - line therapy in the initial management of Parkinson's
Pramipexole and ropinirole
Buspirone
Valproic acid
6- mercaptopurine (6- MP)
30. Relates the amount of drug in the body to the plasma concentration
Ketoralac
Clearance (CL)
Volume of distribution (VD)
Chemical esophagitis
31. Inhibitor of leukotrienes (LTD4) receptors and used in asthma
Drug induced Parkinsonism
Seizures
Zafirlukast and montelukast
Codeine - hydrocodone - and oxycodone
32. What do delta cells in the pancreas produce?
Cerebral hemorrhage
Classic
Aldehyde dehydrogenase
Somatostatin
33. Orthostatic hypotension and QT prolongation
Low potency phenothiazines and ziprasidone
LD50
Aspirin
Inhibit DNA gyrase
34. Analog of hypoxanthine - needs HGPRTase for activation
Rescue therapy
Dextroamphetamines and methamphetamine
Tinnitus - GI bleeding
6- mercaptopurine (6- MP)
35. Common mechanism by which overdose result in death
Depression of medullary and cardiovascular centers
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Aplastic anemia and acute hepatic failure
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
36. Common toxicities of cisplatin
Aminocaproic acid
Dimenhydrinate - meclizine - and other 1st generation
Fluorocarbons and Industrial solvents
Nephro and ototoxicity
37. CCB contraindicated in CHF
Insulin secretagogue - closes ATP- sensitive K+ channel
Verapamil
Physostigmine
Theophylline
38. Nitrate used for acute anginal attacks
Atenolol - acebutolol - and metoprolol
Nondepolarizing type antagonists
Nitroglycerin sublingual tablets
Paclitaxel (taxol)
39. Nitrosoureas with high lipophilicity - used for brain tumors
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Carmustine (BCNU) and lomustine (CCNU)
Beta - blockers
Risperidone
40. Skeletal muscle agent that can block muscarinic receptors
Lithium toxicity
Levodopa
Protamine sulfate
Pancuronium
41. Anti - estrogen used for estrogen receptor + breast cancer
Tamoxifen
Clonidine - and methyldopa
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Rheumatic disease
42. Anti - seizure drugs used also for pain of neuropathic orgin
Dicyclomine - methscopolamine
Betamethasone and dexamethasone
Methadone
Gabapentin
43. Initial DMARD of choice for patients with RA
Methotrexate
Acetazolamide
Methadone - followed by slow dose reduction
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
44. What do beta cells in the pancreas produce?
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Bromocriptine
Antithrombin 3
Insulin
45. This is combined with L- dopa - inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L- dopa and allows for fewer SE's (GI distress - postural hypotension - and dyskinesias)
Cyclophosphamide
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Excessive CNS stimulation (seizures)
Carbidopa
46. SE of colchicine
Sodium channel blockade
Tamoxifen
Primaquine
Kidney and liver toxicity - diarrhea
47. Agents used in treatment of carcinoid tumor
Oxybutynin - dicyclomine
Ketanserin cyproheptadine - and phenoxybenzamine
Pyridostigmine
Maprotiline
48. Somatotropin (GH) analog used in GH deficiency (dwarfism)
Somatrem
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Cholinesterase inhibitors
Constipation - edema - and headache
49. Toxicity of amphotericin
Nephrotoxicity
Nevirapine - amprenavir
Diazepam
Competitive antagonist
50. Constant proportion of cell population killed rather than a constant number
Log - kill hypothesis
Cyclophosphamide
Ketamine
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate