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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Cephalosporin causes kernicterus in neonates
Lispro (Humalog) - aspart - glulisine
Ceftriaxone or cefuroxime
Pre - existing cardiac or renal disease
Mast cell stabilizer
2. Barbiturates may precipitate this hematologic condition
Acute intermittent porphyria
Probenecid and sulfinpyrazone
Clomipramine
Oxytocin
3. Anti - arrhythmics that decrease mortality
B- blockers
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Fexofenadine - loratadine - and cetirizine
First generation due to being more lipid - soluble
4. Inhaled anesthetics are myocardial depressants
Octreotide
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Enflurane and halothane
Sotalol
5. DOC for herpes and its MOA
Tamoxifen
Acyclovir; incorporated into viral DNA and chain termination
Constipation - edema - and headache
Thrombocytopenia
6. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension
Propofol
Prolongs QT interval
Tolerance
Edrophonium
7. Tolerance to all effects of opioid agonists can develop except
Miosis and constipation
Delavirdine - efavirenz - and ribavirin
N- acetylcysteine
Spasmolytic drugs
8. Non ergot agents used as first - line therapy in the initial management of Parkinson's
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Pramipexole and ropinirole
Vitamin K and Fresh frozen plasma (FFP)
Ganirelix
9. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
Gabapentin
Midazolam
Flumazenil
Pregnancy
10. GnRH antagonist with more immediate effects - used for infertility
Dry cough
Ganirelix
Beta blockers
Zafirlukast and montelukast
11. Orthostatic hypotension and QT prolongation
Inhibit DNA gyrase
Low potency phenothiazines and ziprasidone
100% O2 and hyperbaric O2
L- dopa
12. NSAID also available as an ophthalmic preparation
Morphine
Paclitaxel (taxol)
Diclofenac - ketoralac
Elderly patients
13. Carbonic anhydrase inhibitor
Acetazolamide
PCP
Gynecomastia
Oxidation - reduction - hydrolysis
14. MOA of thiazide diuretics
Nicotine
Inhibit Na+/Cl - cotransport
Aspirin
Zileuton
15. This agent cause increased aqueous outflow
Prostaglandin PGF2a
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Liver toxicity
Paclitaxel (taxol)
16. Amphetamine agents
sodium polystyrene sulfonate (Kayexalate)
Dextroamphetamines and methamphetamine
Spasmolytic drugs
Iodide salts
17. Distribution of histamine receptors H1 - H2 - and H3
Reducing progression of heart failure (never use in acute heart failure)
Caffeine
Ethanol
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
18. DOC for status epilepticus
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Alprazolam
Diazepam
Nateglinide
19. The most toxic organophosphate
Parathion
Gynecomastia
Valproic acid
Hydralazine
20. Antidote for digoxin toxicity
Tamsulosin (Flomax)
Digibind
Ribavirin
Low therapeutic index
21. Block glycoprotein IIb/IIIa involved in platelet cross - linking
Esmolol
Abciximab - tirofiban and eptifibatide
Neuroleptanesthesia
Pyridostigmine
22. System that increases in activity with chronic ethanol exposure and may contribute to tolerance
Gynecomastia and hyperkalemia
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
EOS
Ipodate
23. Used in pediatrics to maintain patency of ductus arteriosis
Chemical esophagitis
Carbamazepine
PGE1
B- blockers
24. Leads to respiratory depression progressing to coma and death
Full agonist
Overdose of opioids
Physostigmine
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
25. Common SE of spironolactone
Gynecomastia and hyperkalemia
Insulin release from pancreas by modifying K+ channels
Dimenhydrinate - meclizine - and other 1st generation
Sulfonamides
26. Anti - androgen used for hirsutism in females
Vitamin D
Diazepam
Cyproterone acetate
Physostigmine
27. SE of methyldopa
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28. Antiplatelet drug reserved for patients allergic to aspirin
Cocaine
Benzodiazepines and calcium channel blockers
Ticlopidine
Oxybutynin - dicyclomine
29. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively
Leuprolide
Clozapine
Atrial fibrillation and CHF
Prednisone
30. SE of both warfarin and heparin
Fluoxetine
Bleeding
Pre - existing cardiac or renal disease
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
31. Treatment of resistant pseudomembranous colitis
ORAL vancomycin
Terbutaline
Amrinone and milrinone
Olanzapine - aripiprazole - and sertindole
32. Treat manifestations of Parkinson's disease and EPS
Dry cough
First generation due to being more lipid - soluble
Benztropine - trihexyphenidyl
Bromocriptine
33. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Sodium channel blockade
Atropine - homatropine - C1208 tropicamide
Iodide salts
34. Cholestyramine and colestipol are
Bradykinin and histamine
Chlorpropamide
Bile acid - binding resins
Chloramphenicol
35. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Phenylephrine
Pralidoxime
Noncompetitive antagonist
Ketamine
36. MOA of Bisphosphonates
Haloperidol or pimozide
Inhibits osteoclast bone resorption
Ethosuximide and valproic acid
Risperidone
37. New class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
Ezetimibe (Zetia)
Clonidine - and methyldopa
Kidneys
38. Toxic effect of anticancer drug can be lessened by rescue agents
Testosterone
Dextromethorphan - Codeine
Rescue therapy
Increasing afterload and tissue perfusion declines
39. Long acting beta 2 agonist used in asthma
Acebutolol - atenolol - esmolol - metoprolol
Presynaptic mu - delta - and kappa receptors
Salmeterol
Inhibits osteoclast bone resorption
40. Alternative anticoagulant used if HIT develops
Lepirudin
Benztropine
Hepatic enzymes
Dantrolene
41. Drugs of choice for generalized tonic - clonic and partial seizures
Valproic acid and Phenytoin
Atropine - homatropine - C1208 tropicamide
Flutamide (Eulexin)
Acarbose
42. Toxicities include nephrotoxicity and ototoxicity - leading to a severe interaction with aminoglycosides
Bile acid - binding resins
Cisplatin
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Thioridazine
43. DMARDs are slow acting drugs for
Kidneys
Urinary acidification and activated charcoal or continual nasogastric suction
Rheumatic disease
Olanzapine
44. NSAID used in gout
Excessive hypotension and kidney failure
Increase the DURATION of GABA- mediated chloride ion channels
Indomethacin
Calcitonin (salmon prep)
45. Class II antiarrhythmics are
Rhabdomyolysis
Buspirone
Dipyridamole
B- blockers
46. MOA of class III antiarrhythmics
Postsynaptic Mu receptors
Potassium channel blockers
Platelet aggregation inhibition
block SLUD (salivation - lacrimation - urination - defecation
47. Ultra long acting insulin - has over a day duration of action
TD50
Glargine (Lantus) - detemir
Thyroxine
Carbamazepine - gabapentin - lamotrigine - and valproic acid
48. Opioid used in the management of withdrawal states
Methadone
Bradykinin and histamine
LD50
Glucagon
49. Side effects frequently seen with SSRIs
CNS stimulation; GI upset
High therapeutic index
Cytomel
Olanzapine
50. Allopurinol treats chronic gout by decreasing uric acid production by inhibiting
Metronidazole
Thioamides - iodides - radioactive iodine - and ipodate
Xanthine oxidase
Aplastic anemia and renal toxicity