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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Names of three bisphosphonates available IV
GABA- related targets
Thyroid and steroid hormones
Pamidronate - zoledronate - ibandronate
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
2. Newer NSAID that selectively inhibits COX-2
Clearance (CL)
Midazolam
Nitrous oxide
Celecoxib
3. Anti - arrhythmics that decrease mortality
Dantrolene
Dry cough
B- blockers
Reduce aqueous secretion
4. Cause dizziness - tachycardia - hypotension - and flushing
Olanzapine
Hepatic enzymes
Organic nitrites
Neostigmine
5. SE of hydroxychloroquine
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Cyclophosphamide
Raloxifene (SERM- selective estrogen receptor modulator)
Retinal destruction and dermatitis
6. Site of action of thiazide diuretics
Beta - blockers such as propranolol
Amoxicillin
Hepatic
Work at early distal convoluted tubule
7. Antidepressant associated with neuroleptic malignant syndrome
Amoxapine
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Dopamine
Caffeine
8. SE of mirtazapine
Liver toxicity - increased serum cholesterol
Pregnancy
Minimum alveolar anesthetic concentration (MAC)
Naloxone
9. Monitoring parameter to obtain before initiation of STATINS
10. Anti - seizure medication also used in the prevention of migraines
Retinal destruction and dermatitis
Valproic acid
Methoxyflurane
Hypertrichosis
11. Anti - thyroid drugs
Thioamides - iodides - radioactive iodine - and ipodate
Phenoxybenzamine
Sulfasalazine
Ferrous sulfate
12. Facilitates GABA presynaptic inhibition
Diazepam
Increasing afterload and tissue perfusion declines
Quetiapine
Oral and transdermal forms of nitroglycerin
13. Direct vasodilator of arteriolar smooth muscle
Yohimbine
Hydralazine
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Reducing preload
14. Dose which is lethal to 50% of the population
LD50
NO - chloroform - and diethyl ether
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Oxytocin
15. Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
Alprazolam and Clonazepam
Torsades de pointes
Calcium
Severe hypertension
16. Treatment of motion sickness
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Ceftriaxone or cefuroxime
Scopolamine - meclizine
17. MOA of Cardiac glycosides (eg. digoxin)
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Risperidone
Metrifonate
Norepinephrine and serotonin
18. Antidepressants with no effect on BP - no sedation
Cyanocobalamin (Vit B12)
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Streptomycin
SSRIs
19. Analog of hypoxanthine - needs HGPRTase for activation
Partial agonist
Dolasetron
6- mercaptopurine (6- MP)
'On - off - phenomenon'
20. Inhibitor of leukotrienes (LTD4) receptors and used in asthma
Zafirlukast and montelukast
Low therapeutic index
Diazepam
Atropine - homatropine - C1208 tropicamide
21. Inducers of Cytochrome P450 (CYP450)
Flumazenil
Chlorpropamide - tolbutamide - tolazamide - etc.
Barbiturates - phenytoin - carbamazepine - and rifampin
Beta - blockers such as propranolol
22. Antibiotic causing red - man syndrome - and prevention
Nephrotoxicity
Excessive hypotension and kidney failure
Vancomycin - infusion at a slow rate and antihistamines
Nortriptyline - Desipramine
23. Agents having higher sedation and antimuscarinic effects than other TCA's
Temazpam - trizolam - flurazepam
Tertiary amines
Regular (Humulin R)
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
24. Plasma concentration of a drug at a given time
Cp
Pyridostigmine
Fluorocarbons and Industrial solvents
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
25. Drug of choice for generalized anxiety disorder - Not effective in acute anxiety
Buspirone
Dantrolene
Reduce the loss from area of injection
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
26. Used for Cushing's syndrome (increased corticosteroid)
Inhibit DNA gyrase
Aminoglutethimide
Chlorpheniramine or cyclizine
Dexamethasone suppression test
27. H1 antagonist used in motion sickness
Nortriptyline - Desipramine
Dimenhydrinate - meclizine - and other 1st generation
Decreases protein synthesis by inhibiting 30S ribosome
Prolonged half - life - up to six weeks
28. DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics
CNS depressants
Stimulates cGMP which leads to vascular smooth muscle relaxation
Dantrolene
Administration of Vit. B6 (pyridoxine)
29. Non - depolarizing skeletal muscle antagonist that has short duration
Mivacurium
Full agonist
Increased thromboembolic events
Aminocaproic acid
30. Readily detected markers that may assist in diagnosis of the cause of a drug overdose include
Stimulates cGMP which leads to vascular smooth muscle relaxation
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Propoxyphene
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
31. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
L- dopa
Islets of Langerhans
Diphenhydramine and cimetridine - respectively
Methadone
32. Organophosphate anthelmintic agent with long DOA
Clozapine
Erythropoietin
Clindamycin
Metrifonate
33. Ability to produce less than 100% of the response
Fluorocarbons and Industrial solvents
Dextroamphetamines and methamphetamine
Partial agonist
Phase I
34. B- blockers that are more cardioselective
Beta -1 selective blockers
Raloxifene
Additive CNS depression
Ceftriaxone or cefuroxime
35. SE of phenytoin
AZT (zidovudine)
Amiodarone
Gingival hyperplasia - nystagmus - diplopia and ataxia
L- asparaginase
36. Toxicity of anticholinergics
Mivacurium
block SLUD (salivation - lacrimation - urination - defecation
Ethanol - Barbiturates - and Benzodiazepines
Adalimumab - infliximab and etanercept
37. Barbiturates may precipitate this hematologic condition
Respiratory failure
'On - off - phenomenon'
Red urine discoloration
Acute intermittent porphyria
38. Atypical antipsychotic causing high prolactin levels
Magnesium sulfate
Edrophonium
2 to 3 weeks
Risperidone
39. 1st generation antihistamine that is least sedating
Hyperuricemia - hypokalemia and hyperglycemia
Dolasetron
Chlorpheniramine or cyclizine
Rifampin
40. Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso - enzyme.
Levodopa
Terfenadine and astemizole (have been removed from the market)
Pancuronium
Hypokalemia
41. Scabicide organophosphate
Sulfonamides
Metrifonate
Beta -1 selective blockers
Malathion
42. Topical DOC in impetigo
Amrinone and milrinone
Pentoxifylline
Clonidine - and methyldopa
Topical mupirocin (Bactroban)
43. SE of salicylates
Mirtazapine
Rhabdomyolysis
Tinnitus - GI bleeding
Hepatotoxicity
44. Drugs of choice for generalized tonic - clonic and partial seizures
Valproic acid and Phenytoin
Dextroamphetamines and methamphetamine
Verapamil
Pre - existing cardiac or renal disease
45. Drug that causes gray baby syndrome and aplastic anemia
Chloramphenicol
Diclofenac - ketoralac
Apraclonidine - brimonidine
Pilocarpine
46. Benzodiazepine used for anxiety
Reducing progression of heart failure (never use in acute heart failure)
Raloxifene
Alprazolam
Rhabdomyolysis
47. ADH agonist used for pituitary diabetes insipidus
Hydralazine
Megaloblastic anemia
Desmopressin (DDAVP)
Calcitonin (salmon prep)
48. Oral contraceptive available in a transdermal patch
Carbamazepine
Carbenicillin - piperacillin and ticarcillin
Ortho - Evra
Bradykinin and histamine
49. PTU (propylthiouracil) MOA
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Methicillin - nafcillin - and dicloxacillin
Dopamine
Carvedilol
50. DOC for bipolar affective disorder
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Lithium
Rifampin
Aspirin