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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug of choice for leprosy
Ceftriaxone
Dapsone - rifampin and clofazimine combination
Hypoglycemia
Organic nitrites
2. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration
Tolerance
Hydroxychloroquine
Nitrous oxide
Dry cough
3. Drug used for N. gonorrhea in females
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Ceftriaxone
Adenosine
Constipation - edema - and headache
4. Another pneumonic for anticholinergic toxicity
5. Agent used for acute muscle spasm
Aminocaproic acid
Mivacurium
Cyclobenzaprine
Cholinesterase inhibitors
6. Major SE of bisphosphonates
Potassium channel blockers
Gynecomastia hyperkalemia - and impotence
St. Anthony's Fire
Chemical esophagitis
7. Difference between aspirin and other NSAIDS
Interferon alpha
Aspirin irreversibly inhibits cyclooxygenase
PTU
Maprotiline
8. This is combined with L- dopa - inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L- dopa and allows for fewer SE's (GI distress - postural hypotension - and dyskinesias)
Folic acid
Aspirin
Carbidopa
Phase I
9. Moderate opioid agonists
Codeine - hydrocodone - and oxycodone
Diphenoxylate - Loperamide
Amitriptyline
First pass effect
10. The ratio of the rate of elimination of a drug to its plasma concentration
Clearance (CL)
Benztropine
Ketoralac
Prazosin - terazosin and doxazosin (- AZOSIN ending)
11. This parenteral beta blocker is a short acting (minutes)
Thick ascending limb
Vincristine
Glucagon
Esmolol
12. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Acebutolol - atenolol - esmolol - metoprolol
Thioridazine
Pindolol and acebutolol
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
13. Peakless ling acting insulin
LSD
Insulin glargine
Potential for development of Reye's syndrome
Minimum alveolar anesthetic concentration (MAC)
14. Inhaled anesthetic that may sensitize the myocardium to arrhythmogenic effects of catecholamines and has produced hepatitis
Half - life (T1/2)
Gynecomastia
Halothane
Nicotine
15. Common SE of tamoxifen and raloxifene
Hot flashes
Atracurium
Ketanserin cyproheptadine - and phenoxybenzamine
Sinus tachycardia and serious arrhythmias
16. Some cell cycle non - specific drugs
Hyperuricemia - hypokalemia and ototoxicity
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Sodium channel blockers
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
17. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure
Gynecomastia and hyperkalemia
Respiratory failure
inhibit phospholipase A2
Nefazodone
18. Antiarrhythmic that exhibits Class II and III properties
Adenosine
Sotalol
Desmopressin (DDAVP)
Morphine and fentanyl
19. Drug ofter used in combination with TNF - alpha inhitors for RA
Chlordiazepoxide and Diazepam
Methotrexate
Buspirone
G- CSF (filgrastim) and GM- CSF (sargramostim)
20. Scabicide organophosphate
Salmeterol
Malathion
Fluorocarbons and Industrial solvents
Na+/K+ exchange
21. Antidote used for beta agonist toxicity (eg. Metaproterenol)
Hepatic
Amoxapine
Esmolol
Phenylephrine
22. Treatment of myasthenia gravis
Pyridostigmine
Diazepam
Propofol
Flumazenil
23. Causes bone marrow suppression
Methotrexate
Potassium channel blockers
Alprazolam
Pregnancy
24. Antidepressant associated with neuroleptic malignant syndrome
Amoxapine
Nitrous oxide
First order kinetics
Morphine and fentanyl
25. Drug used in neuroleptic malignant syndrome
Tissue plasmin activator
Inhibit Na+/Cl - cotransport
Iodide salts
Dantrolene
26. Names of three bisphosphonates available IV
Decreases protein synthesis by inhibiting 30S ribosome
Pamidronate - zoledronate - ibandronate
Adenosine
Inhibit DNA gyrase
27. Important in synthesis of glucose to glycogen in the liver
Severe hypertension
GLUT 2
CNS toxicity
Finasteride (Proscar and Propecia respectively)
28. Arterial vasodilator that works by opening K+ channels
Cortisone and hydrocortisone (equivalent to cortisol)
Minoxidil
Diphendydramine
Constipation - edema - and headache
29. W/D from this drug causes anxiety and mental discomfort
Dantrolene
Ethanol - Barbiturates - and Benzodiazepines
Nicotine
Regular (Humulin R)
30. SE of Thiazolindinediones
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Prolonged half - life - up to six weeks
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Allopurinol
31. Agent used for anemias associated with renal failure
Erythropoietin
Dipyridamole
Competitive antagonist
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
32. SE for ganciclovir
Codeine - hydrocodone - and oxycodone
Delavirdine - efavirenz - and ribavirin
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Neutro - leuko and thrombocytopenia
33. Term for a high margin of safety
Inhibits osteoclast bone resorption
High therapeutic index
Cardiac anomalies and is contraindicated in pregnancy or lactation
lispro insulin - aspart insulin - glulisine insulin
34. NSAID that is used for acute condition - such as pre - op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
ED50
PGE1
Amiodarone
Ketoralac
35. Opioids used in anesthesia
Morphine and fentanyl
Islets of Langerhans
Chlorpropamide - tolbutamide - tolazamide - etc.
Buspirone
36. The most important sign of withdrawal syndrome
Diclofenac - ketoralac
Disulfiram - like reaction
Excessive CNS stimulation (seizures)
Aldehyde dehydrogenase
37. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)
38. Good hypnotic activity with less CNS SE than most benzodiazepines
Tubocurarine
Enflurane and halothane
Zolpidem - zaleplon
Vancomycin - infusion at a slow rate and antihistamines
39. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
EOS
Zafirlukast and montelukast
Bupropion
40. Most dangerous of the currently popular hallucinogenic drugs - OD leads to nystagmus - marked hypertension - and seizures - presence of both horizontal and vertical nystagmus is pathognomonic
Competitive antagonist
Sodium bicarbonate
PCP
nephro and ototoxicity
41. SE of penicillamine
Aplastic anemia and renal toxicity
Noncompetitive antagonist
Parathion
Clearance (CL)
42. This is the drug of choice for anaphylactic shock
Epinephrine
Cyanide toxicity treated with sodium thiosulfate
Ortho - Evra
Acetazolamide
43. DOC for paroxysmal supraventricular tachycardia (PSVT)
Urinary acidification and activated charcoal or continual nasogastric suction
Use in IgE mediated allergic reaction
Hydroxychloroquine
Adenosine
44. Very rapid acting insulin - having fastest onset and shortest duration of action
Amantadine
Streptokinase
Lispro (Humalog) - aspart - glulisine
Prilocaine
45. Nitroprusside vasodilates
Albuterol
Atropine
Naloxone
Arteries and veins
46. Withdrawal from this drug causes lethargy - irritability - and headache
High therapeutic index
Morphine and fentanyl
Buspirone
Caffeine
47. These agents are congeners of Amphetamine
48. Agents that block L- type calcium channel
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
block SLUD (salivation - lacrimation - urination - defecation
Calcium channel blockers
Isoflurane
49. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Neostigmine
Pyridostigmine
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
Clonazepam
50. Important in muscle and adipose tissue for glucose transport across muscles and TG storage by lipoprotein lipase activation
Oral and transdermal forms of nitroglycerin
Streptokinase
Miosis and constipation
GLUT 4