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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Occurs when sedative hypnotics are used chronically or at high doses






2. SE of acetaminophen






3. Antidote used for benzodiazepine toxicity






4. Topical DOC in impetigo






5. Cystitis - postoperative bladder spasms - or incontinence






6. Agent used in CHF that is a selective alpha and nonselective beta blocker






7. 'Date rape drug'






8. Initial DMARD of choice for patients with RA






9. Leads to respiratory depression progressing to coma and death






10. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression






11. Different steps of Phase I






12. MOA of thiazide diuretics






13. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure






14. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation






15. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia






16. Longer acting Beta 2 agonist is recommended for prophylaxis of asthma






17. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB






18. Ability of a drug to produce 100% of the maximum response regardless of the potency






19. Anti - seizure drugs used also for bipolar affective disorder (BAD)






20. Lactam that can be used in PCN allergic patients






21. Anti - viral agents associated with Stephen Johnson syndrome






22. Vancomycin MOA






23. Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)






24. Amino acid derivative - active as an insulin secretagogue






25. Beta 2 agonist used to suppress premature labor - but cardiac stimulatory effects may be hazardous to mother and fetus






26. SE of nesiritide






27. CCB contraindicated in CHF






28. SE of long term (>5 days) corticosteroid therapy and remedy






29. Drugs of choice for absence seizures






30. Drug of choice for myoclonic seizures






31. Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons






32. DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics






33. MOA of lovastatin (STATIN)






34. Amphetamine agents






35. Common SE of sulfonylureas - repaglinide - and nateglinide






36. Prototypical drug is atropine






37. Antidote used in poisonings: copper (Wilson's disease) - lead - mercury - and arsenic






38. Major SE of bisphosphonates






39. Vascular effects of metformin






40. Antiarrhythmic that exhibits Class II and III properties






41. Antidote for acetaminophen toxicity






42. Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine - like side effects






43. Chronic orthostatic hypotension can be treated with






44. MOA of nesiritide






45. Ergot alkaloid that is a partial agonist at D2 receptors in the brain - used for patients who are refractory or cannot tolerate levodopa - causes erythromelalgia






46. For rebound HTN from rapid clonidine withdrawal






47. Class of anti - arrhythmics that has a pro - arrhythmic effect (CAST trial) - therefore are used as last line agents






48. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)






49. Selectivity of a drug for its receptor






50. These prevent the action of Ach at the skeletal muscle endplate to produce a 'surmountable blockade -' effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)