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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Activation of these receptors open K+ ion channels to cause membrane hyperpolarization
Buspirone
Metformin
Long acting cholinesterase inhibitors
Postsynaptic Mu receptors
2. Ability to bind reversibly to the same site as the drug and without activating the effector system
Sodium channel blockade
Competitive antagonist
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Methotrexate
3. MOA of AGI's
Pancuronium
Oxytocin - ergonovine and ergotamine
Caffeine
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
4. SE of hydroxychloroquine
Lipoprotein lipase
Glucocorticoids
Cytomel
Retinal destruction and dermatitis
5. Drug notorious for causing pseudomembranous colitis
ED50
Penicillamine
Clindamycin
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
6. Anti - estrogen used for estrogen receptor + breast cancer
Pyridostigmine
Depression of medullary and cardiovascular centers
Tamoxifen
Inhibit Na+/Cl - cotransport
7. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Valproic acid - carbamazepine - phenytoin and gabapentin
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Peripheral neuritis and hepatitis
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
8. Antidote used for carbon monoxide poisoning
Cefixime (3rd) generation
Pralidoxime
100% O2 and hyperbaric O2
Nitrites
9. SSRI less likely to cause a withdrawal syndrome
Fluoxetine
Morphine
sulfamethoxazole/ trimethoprim
Nonselective Muscarinic Antagonists
10. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Cholinesterase regenerators - pralidoxime
Nandrolone - oxymetholone - and oxandrolone
Calcium channel blockers
Caffeine
11. Antipsychotics that reduce positive symptoms only
Abciximab - tirofiban and eptifibatide
Chlorpheniramine or cyclizine
Older antipsychotics
Dexamethasone suppression test
12. Interaction with this drug requires dose reduction of 6- MP
Nonselective Muscarinic Antagonists
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Lepirudin
Allopurinol
13. Benzodiazepines used to promote sleep
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
Temazpam - trizolam - flurazepam
Sinus tachycardia and serious arrhythmias
REM is decreased
14. Beta 1 agonists used in acute CHF
Dobutamine and dopamine
Amoxapine
Marijuana
Fludrocortisone and deoxycorticosterone
15. Block glycoprotein IIb/IIIa involved in platelet cross - linking
Abciximab - tirofiban and eptifibatide
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Methadone
6- mercaptopurine (6- MP)
16. Four main actions of NSAIDS
Hepatotoxicity
Inhibit Na+/Cl - cotransport
'On - off - phenomenon'
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
17. Antidote used for opioid toxicity
Digibind
Retinal destruction and dermatitis
Clindamycin
Naloxone (IV) - naltrexone (PO)
18. Antiprogestin used as potent antagonist of GC receptor
Skeletal muscle tremor - tachycardia
Mifepristone
Abstinence syndrome
Dexrazoxane
19. Drug of choice for generalized anxiety disorder - Not effective in acute anxiety
Buspirone
Cytomel
Amiodarone
Deferoxamine
20. MOA of local anesthetics (LA's)
Pralidoxime
Block voltage - dependent sodium channels
Aldehyde dehydrogenase
Naloxone (IV) - naltrexone (PO)
21. PCN active against pseudomonas
sodium polystyrene sulfonate (Kayexalate)
Pregnancy
Insulin secretagogue - closes ATP- sensitive K+ channel
Carbenicillin - piperacillin and ticarcillin
22. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
Positive Comb's test - depression
Autocoids
Somatostatin
Tamsulosin
23. Beta 2 agonist used to suppress premature labor - but cardiac stimulatory effects may be hazardous to mother and fetus
Terbutaline
Nonselective Muscarinic Antagonists
Niacin
Potency
24. Only direct acting agent that is very lipid soluble and used in glaucoma
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Pilocarpine
Oxytocin
Neutro - leuko and thrombocytopenia
25. This agent regenerates active cholinesterase and is a chemical antagonist used to treat organophosphate exposure
Amiodarone
B- blockers
Pralidoxime
B- blockers
26. SE of amrinone
Older antipsychotics
Ipodate
Heparin
Thrombocytopenia
27. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction
Doxepin
Antithrombin 3
Pilocarpine - carbachol - physostigmine
inhibit phospholipase A2
28. Monitoring parameter to obtain before initiation of STATINS
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29. MOA of thiazide diuretics
Inhibit Na+/Cl - cotransport
Lithium
Cartilage damage
Mirtazapine
30. Decreases liver triglycerol synthesis
Niacin
Megaloblastic anemia
Rebound HTN - sedation - dry mouth
Hydralazine
31. Anticoagulant of choice in pregnancy
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
Adenosine
Heparin
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
32. Reason fluoroquinolones are contraindicated in children and pregnancy
Cartilage damage
Timolol
Potassium channel blockers
Neuromuscular blocking drugs
33. GABA agonist in the spinal cord
5-7 days
Baclofen
Diazepam
Acarbose - miglitol
34. Anti - arrhythmics that decrease mortality
Agranulocytosis
Penicillamine
Anterograde amnesia
B- blockers
35. NSAID that is used for acute condition - such as pre - op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
IV administration
Nausea
Bleeding
Ketoralac
36. GHRH analog used as diagnostic agent
Sermorelin
Atrial fibrillation and CHF
Steady state
hydroxyzine (Atarax)
37. Aspirin is contraindicated in children with viral infection
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38. Alternative anticoagulant used if HIT develops
Aspirin - Nitrates - CCB - and Beta blockers
Nortriptyline - Desipramine
Lepirudin
Zolpidem
39. Class of drugs that may cause cross - sensitivity with thiazide diuretics
Inhibit Cytochrome P450 3A4
Sulfonamides
Cosyntropin
Cocaine 'super - speed'
40. IV Drug used Hypertensive Crisis
Ketoralac
Inhibit dihydropteroate synthase
Nondepolarizing type antagonists
Nitroprusside
41. MOA of quinolones
Pulse therapy
inhibits HMG COA reductase
Inhibit DNA gyrase
Calcium channels
42. Irreversible - nonselective COX inhibitor
Phentolamine
Aspirin
Prednisone
Succinylcholine
43. Thrombolytic that can cause allergic reaction
Older antipsychotics
Volume of distribution (VD)
2 to 3 weeks
Streptokinase
44. Vascular effects of metformin
Clozapine
Acetazolamide
Rhabdomyolysis and Hepatotoxicity
Decreased micro and macro vascular disease
45. MOA of Leflunomide (newer agent)
Rebound HTN - sedation - dry mouth
ED50
Nephro and ototoxicity
Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis - decreased T cell proliferation and decreased antibody production by B cells
46. Antidote for methotrexate toxicity
Leucovorin
Olanzapine - aripiprazole - and sertindole
Demeclocycline
Yohimbine
47. Fibrates (gemfibrozil) increase activity of
Phase I
Phenobarbital
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Lipoprotein lipase
48. Aspirin reduces mortality in unstable angina by
Efficacy
Pramipexole and ropinirole
Platelet aggregation inhibition
Degradation of fibrin clots and are administered IV
49. Agent used to treat chronic gout by increasing uric acid secretion and excretion
Gynecomastia hyperkalemia - and impotence
Probenecid and sulfinpyrazone
Presynaptic mu - delta - and kappa receptors
Clozapine
50. THC is active ingredient - SE's include impairment of judgment - and reflexes - decreases in blood pressure and psychomotor performance occur
Hepatic enzymes
Marijuana
Red urine discoloration
Calcium channel blockers