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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Class of anti - arrhythmics that has a pro - arrhythmic effect (CAST trial) - therefore are used as last line agents
Postsynaptic Mu receptors
Class IC (flecainide - propafenone - moricizine)
Estrogen
Atropine - homatropine - C1208 tropicamide
2. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Glucocorticoids
Ipodate
Topical mupirocin (Bactroban)
Beta - blockers such as propranolol
3. Barbiturate used for the induction of anesthesia
Nonselective Muscarinic Antagonists
Esmolol
Efficacy
Thiopental
4. Lactam that can be used in PCN allergic patients
Magnesium sulfate
Halothane
Aztreonam
Aldehyde dehydrogenase
5. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
Increase the DURATION of GABA- mediated chloride ion channels
Aztreonam
Acarbose
Tamsulosin
6. Tolerance to all effects of opioid agonists can develop except
Miosis and constipation
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
Tolerance
Streptomycin
7. SE for Lamotrigine
Stevens - Johnson syndrome
Repaglinide
Degradation of fibrin clots and are administered IV
Methotrexate
8. NSAID contraindicated in gout
Aspirin
Ticlopidine
Spironolactone
Arteries and veins
9. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension
Acyclovir; incorporated into viral DNA and chain termination
Fluoxetine (Sarafem)
Pentoxifylline
Propofol
10. This agent regenerates active cholinesterase and is a chemical antagonist used to treat organophosphate exposure
Scotch tape technique and mebendazole
Toremifene (Fareston)
Pralidoxime
Cocaine
11. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Thick ascending limb
Acetazolamide
Methadone
Raloxifene
12. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
Haloperidol
Rescue therapy
Atracurium
Carbenicillin - piperacillin and ticarcillin
13. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
Nitroglycerin sublingual tablets
Rhabdomyolysis and Hepatotoxicity
Inhibits osteoclast bone resorption
Amitriptyline
14. T3 compound less widely used
Cholinesterase regenerators - pralidoxime
Nephro and ototoxicity
Haloperidol
Cytomel
15. Longer acting Beta 2 agonist is recommended for prophylaxis of asthma
Dextroamphetamines and methamphetamine
Cephalosporins
Salmeterol
Potency
16. Prostaglandins that cause abortions
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Gynecomastia hyperkalemia - and impotence
Ondansetron - granisetron - dolasetron and alosetron
Esmolol
17. H1 blocker that is also a serotonin antagonist
Methimazole and propylthiouracil (PTU)
Low potency phenothiazines and ziprasidone
Cisplatin
Cyproheptadine
18. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Clomiphene and tamoxifen
Ketamine
Seizures
Nesiritide (BNP)
19. Inhibitor of lipoxygenase
G- CSF (filgrastim) and GM- CSF (sargramostim)
Zileuton
Erythromycin
inhibits Na+/K+/2Cl - cotransport
20. Carbamate with intermediate action - used for+A1170 postoperative and neurogenic ileus and urinary retention
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Neostigmine
Reduce inhibition - suppress anxiety - and produce relaxation
21. MOA of thiazide diuretics
Nitroprusside
Thyroid and steroid hormones
Leucovorin
Inhibit Na+/Cl - cotransport
22. Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates
Allopurinol
Olanzapine
Odansetron - granisetron
Dimenhydrinate - meclizine - and other 1st generation
23. Antidote for hyperkalemia
Mifepristone
Dextroamphetamines and methamphetamine
sodium polystyrene sulfonate (Kayexalate)
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
24. Treatment of resistant pseudomembranous colitis
Antipyretic and analgesic activity
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
ORAL vancomycin
Spironolactone
25. Antidote used for benzodiazepine toxicity
Prazosin - terazosin - doxazosin
Nonselective Muscarinic Antagonists
Flumazenil
First order kinetics
26. CCB are DOC for
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27. 3 zones of adrenal cortex and their products
Physostigmine
GLUT 4
Prolonged half - life - up to six weeks
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
28. Carbamazepine may cause
Protamine sulfate
Nortriptyline - Desipramine
PCP
Agranulocytosis
29. Ability to bind reversibly to the same site as the drug and without activating the effector system
Competitive antagonist
Tamsulosin
Bromocriptine
Aminocaproic acid
30. Thrombolytic that can cause allergic reaction
Streptokinase
Midazolam
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Raloxifene (SERM- selective estrogen receptor modulator)
31. Non - steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
Increasing afterload and tissue perfusion declines
Ketanserin cyproheptadine - and phenoxybenzamine
Diethylstilbestrol (DES)
Dobutamine
32. Agent for pernicious anemia
Naltrexone
Cyanocobalamin (Vit B12)
Hypoglycemia
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
33. Vascular effects of metformin
Atrial fibrillation and CHF
Decreased micro and macro vascular disease
Cocaine 'super - speed'
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
34. Nitrate used to prevent further attacks
Oral and transdermal forms of nitroglycerin
Neostigmine
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Topical mupirocin (Bactroban)
35. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis
Celecoxib and rofecoxib
Doxepin
Postsynaptic Mu receptors
Bleomycin
36. Cystitis - postoperative bladder spasms - or incontinence
Ethinyl estradiol and mestranol
Rescue therapy
Amphetamines
Oxybutynin - dicyclomine
37. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure
Propofol
Nefazodone
Pamidronate - zoledronate - ibandronate
Acarbose - miglitol
38. Common SE of sulfonylureas - repaglinide - and nateglinide
Hypoglycemia
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
Acid reflux disease - duodenal ulcer and peptic ulcer disease
Valproic acid
39. Side effects occuring in antipsychotics that block dopamine
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Scotch tape technique and mebendazole
Repaglinide
Buprenorphine
40. Main route of metabolism for benzodiazepines
Tolerance
Hepatic
Nesiritide (BNP)
Thyroid and steroid hormones
41. Antidote for methotrexate toxicity
Oxybutynin - dicyclomine
Leucovorin
Desflurane
Efficacy
42. Anti - rheumatic agent also used for ulcerative colitis
Sulfasalazine
Phentolamine
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Buprenorphine
43. Antiplatelet drug reserved for patients allergic to aspirin
Ticlopidine
Organic nitrites
Dry cough - hyperkalemia
Diazepam
44. Irreversible condition resulting from the use of antipsychotics - reserpine at high doses - and MPTP (by- product of illicit meperidine analog)
Drug induced Parkinsonism
Testicular cancer
Buspirone
Pamidronate - zoledronate - ibandronate
45. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Vitamin K or fresh frozen plasma
Cartilage damage
Clonazepam
Protease inhibitors
46. SE of INH
Thiopental
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Peripheral neuritis and hepatitis
Probenecid and sulfinpyrazone
47. Peakless ling acting insulin
Dapsone - rifampin and clofazimine combination
Calcium channel blockers
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Insulin glargine
48. Diuretic used to antagonize aldosterone receptors
Fluphenazine and haloperidol
6- mercaptopurine (6- MP)
Most are thought to act at GABA- A receptor - chloride channel
Spironolactone
49. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
LD50
Selegiline
St. Anthony's Fire
Dantrolene
50. Regimen used for breast cancer
Maintenance dose (Cp*(CL/F))
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Sedation
Miosis and constipation