SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Neurotransmitters affected by the action of antidepressants
Midodrine
Diphenhydramine and cimetridine - respectively
Constipation - edema - and headache
Norepinephrine and serotonin
2. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression
Potency
Carboplatin
Cocaine
inhibit phospholipase A2
3. SE of amrinone
Procarbazine
Dextroamphetamines and methamphetamine
Olanzapine - aripiprazole - and sertindole
Thrombocytopenia
4. Increase bone density - also being tested for breast CA prophylaxis
Bleeding
Raloxifene (SERM- selective estrogen receptor modulator)
Nadolol
Adalimumab - infliximab and etanercept
5. Agent effective in physiologic and essential tremor
Nortriptyline - Desipramine
Baclofen
Metrifonate
Propranolol
6. Allopurinol treats chronic gout by decreasing uric acid production by inhibiting
NO - chloroform - and diethyl ether
Nondepolarizing type antagonists
Xanthine oxidase
Barbiturates - phenytoin - carbamazepine - and rifampin
7. Biguanide
Beta - blockers such as propranolol
Warfarin (PT)
Tizanidine
Metformin
8. For rebound HTN from rapid clonidine withdrawal
Betamethasone and dexamethasone
Phentolamine
Sulfonamides
Buspirone
9. ADH agonist used for pituitary diabetes insipidus
Marijuana
Side - effect profile and prior pt response
Arginine
Desmopressin (DDAVP)
10. Slightly increased risk of breast cancer - endometrial cancer - heart disease (questionable) - has beneficial effects on bone loss
Fluorocarbons and Industrial solvents
Hypokalemia
Estrogen
Celecoxib and rofecoxib
11. Anti - psychotics available in depot preparation
Atropine
Stevens - Johnson syndrome
Ezetimibe (Zetia)
Fluphenazine and haloperidol
12. SE of hydroxychloroquine
Retinal destruction and dermatitis
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Liver toxicity
13. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
14. Metronidazole SE if given with alcohol
Disulfiram - like reaction
Reduce inhibition - suppress anxiety - and produce relaxation
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Aspirin
15. NSAID also available as an ophthalmic preparation
Diclofenac - ketoralac
Folic acid
Anterograde amnesia
Dimercaprol
16. Products of Phase II conjugation
Glucuronate - acetic acid - and glutathione sulfate
Lupus - like syndrome
Methotrexate
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
17. Loops lose and thiazide diuretics retain
Hypertension
Calcium
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Methimazole and propylthiouracil (PTU)
18. Tolerance to all effects of opioid agonists can develop except
Miosis and constipation
Acarbose - miglitol
Aspirin - Nitrates - CCB - and Beta blockers
Clomipramine - fluoxetine and fluvoxamine
19. Estrogen mostly used in oral contraceptives (OC)
Ethinyl estradiol and mestranol
TD50
Lactic acidosis
ORAL vancomycin
20. Dose which is lethal to 50% of the population
LD50
Acarbose
Raloxifene
Interleukin 11 (oprelvekin)
21. Strength of interaction between drug and its receptor
Testosterone
Cyclophosphamide
Phentolamine
Affinity
22. Angiotensin receptor blockers do Not cause
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Dry cough
Acyclovir; incorporated into viral DNA and chain termination
Glucocorticoids
23. Drug used for N. gonorrhea in females
Ceftriaxone
Metrifonate
Selegiline
Atrial fibrillation and CHF
24. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Glucocorticoids
Raloxifene
Ketoralac
Opioid Analgesics
25. Prototype antagonist of H1 and H2 receptors
Naloxone
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Affect calcium - potassium - and sodium channels
Diphenhydramine and cimetridine - respectively
26. Drug elimination with a constant amount metabolized regardless of drug concentration
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Kidney and liver toxicity - diarrhea
Zero order kinetics
Buspirone
27. HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
Morphine
lispro insulin - aspart insulin - glulisine insulin
Leucovorin
Protease inhibitors
28. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Probenecid and sulfinpyrazone
Muscarinic blockers
Cholinesterase regenerators - pralidoxime
Ipodate
29. SE of nesiritide
Excessive hypotension and kidney failure
Morphine - methadone - meperidine - and fentanyl
Propoxyphene
GLUT 2
30. SE of CCB
Constipation - edema - and headache
Tizanidine
Disulfiram - like reaction
Alkylating agent
31. Pneumonic for beta receptors
REM is decreased
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Nicotine
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
32. Nitrosoureas with high lipophilicity - used for brain tumors
Peripheral neuritis and hepatitis
Xanthine oxidase
Carmustine (BCNU) and lomustine (CCNU)
LD50
33. DOC for giardia - bacterial vaginosis - pseudomembranous colitis - and trichomonas
Metronidazole
Carbidopa
CNS depressants
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
34. Agents that block L- type calcium channel
Calcium channel blockers
Fluorocarbons and Industrial solvents
ACE inhibitors
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
35. Drug used in cancer therapy causes Cushing - like symptoms
Radioactive iodine
Prednisone
Amphetamines
Thioamides - iodides - radioactive iodine - and ipodate
36. DOC for influenza A
Aplastic anemia and acute hepatic failure
Amantadine
GLUT 4
Ceftriaxone or cefuroxime
37. A1a - selective blocker with no effects on HTN used for BPH
Penicillamine
Tizanidine
Tamsulosin (Flomax)
Skeletal muscle tremor - tachycardia
38. Additive effects when Sedative - Hypnotics used in combination with these agents
CNS depressants
Tamsulosin (Flomax)
Neutropenia and agranulocytosis
G- CSF (filgrastim) and GM- CSF (sargramostim)
39. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Letrozole - anastrozole
Phenylephrine
IV and IM (only LMW)
Clonazepam
40. Antidote used for organophosphate/anticholinesterase poisoning
Atropine - pralidoxime (2- PAM)
Labetalol and carvedilol
Cytomel
Amiodarone
41. Shock due to septicemia or myocardial infarction is made worse by
Nephrotoxicity
Increasing afterload and tissue perfusion declines
Therapeutic index
Drug induced Parkinsonism
42. Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates
Thyroid and steroid hormones
Allopurinol
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
TD50
43. Treatments available for nicotine addiction
High therapeutic index
PGE1
Patches - gum - nasal spray - psychotherapy - and bupropion
Betamethasone and dexamethasone
44. Available bisphosphonates
Thioamides - iodides - radioactive iodine - and ipodate
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Depression of medullary and cardiovascular centers
Clomiphene and tamoxifen
45. Antidote used for acetaminophen (APAP) toxicity
Dolasetron
Constipation - edema - and headache
Additive CNS depression
N- acetylcysteine (Mucomyst)
46. Methyldopa is contraindicated in
Meperidine
Minoxidil
Suramin
Geriatrics due to its CNS (depression) effects
47. Enzyme that metabolizes acetaldehyde to acetate
Aldehyde dehydrogenase
Aminocaproic acid
Succinylcholine
Arginine
48. MOA of drug or foods (grapefruit juice) that increase statin effect
Sodium channel blockade
Inhibit Cytochrome P450 3A4
Desflurane
Penicillamine
49. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property
Liver enzyme INDUCTION
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
inhibits HMG COA reductase
Metronidazole
50. Antidepressant with MOA as alpha 2 antagonist - has effects on both 5- HT and NE - blocks histamine receptors - and is sedating
Dantrolene
Mirtazapine
Capsaicin
Acyclovir; incorporated into viral DNA and chain termination