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USMLE/COMLEX Step 1 Pharmacology One Liners

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Agent used neutropenia especially after chemotherapy

2. Anticancer drug also used in RA - produces acrolein in urine that leads to hemorrhagic cystitis

3. Two toxicities of aminoglycosides

4. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively

5. Structurally related to acetylcholine - used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation

6. Ultra long acting insulin - has over a day duration of action

7. Different steps of Phase I

8. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure

9. Anti - androgen used for hirsutism in females

10. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)

11. Cutaneous flush and be reduced by pretreatment with

12. Beta 1 agonist toxicity

13. Used for hairy cell leukemia; it stimulates NK cells

14. CCB are DOC for

15. Selectivity of a drug for its receptor

16. MOA of loop diuretics

17. Anti - androgen used for prostate cancer

18. Sedation is a common side effect of these drugs - they lower seizure threshold - uses include BAD - acute panic attacks - phobias - enuresis - and chronic pain and their overdose can be deadly

19. Newer atypical antipsychotic used for bipolar disorder - known to cause weight gain - and adversely affect diabetes

20. Opioid available trans - dermally

21. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property

22. Associated with an increased incidence of cataracts in patients treated for glaucoma

23. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)

24. SE of salicylates

25. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients

26. Common SE of tamoxifen and raloxifene

27. Peakless ling acting insulin

28. Routes of administration of heparin

29. Lithium is associated with this congenital defect

30. This is combined with L- dopa - inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L- dopa and allows for fewer SE's (GI distress - postural hypotension - and dyskinesias)

31. Anti - seizure drugs used also for pain of neuropathic orgin

32. Potassium sparing diuretics inhibit

33. SE of amrinone

34. Regimen used for non - Hodgkin's lymphoma

35. DOC for tx of pseudomembranous colitis

36. Interaction with this drug requires dose reduction of 6- MP

37. These agents are used as antidiarrheal

38. Agent used to treat MI and to reduce incidence of subsequent MI

39. Almost all local anesthetics have this property and sometimes require the administration of vasoconstrictors (ex. Epinephrine) to prolong activity

40. A hormone whose mechanism of action (MOA) utilizes intracellular receptors

41. Treatment of choice for organophosphate overdose

42. DOC for Legionnaires' disease

43. ADH agonist used for pituitary diabetes insipidus

44. Anti - viral with a dose limiting toxicity of pancreatitis

45. Anti - estrogen used for estrogen receptor + breast cancer

46. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)

47. Antidote used for methanol and ethylene glycol

48. Some side effects of corticosteroids

49. Median effective dose required for an effect in 50% of the population

50. Beta 1 agonists used in acute CHF