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USMLE/COMLEX Step 1 Pharmacology One Liners

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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. SE of minoxidil

2. Distribution of histamine receptors H1 - H2 - and H3

3. Sedation is a common side effect of these drugs - they lower seizure threshold - uses include BAD - acute panic attacks - phobias - enuresis - and chronic pain and their overdose can be deadly

4. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis

5. Concurrent use of fibrates and statins increases risk of

6. Anti - thyroid drugs

7. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)

8. Pungent inhaled anesthetic which leads to high incidence of coughing and vasospasm

9. Concern using lithium

10. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion

11. Anti - psychotic not shown to cause tardive dyskinesia

12. DOC for febrile seizures

13. Thrombolytic that can cause allergic reaction

14. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation

15. Second generation sulfonylurea

16. Amount of drug necessary to elicit a biologic effect; refers to the drug's strength

17. Interferes with activity of T- lymphocytes

18. Antidote used for lead poisoning

19. Dopamine agonist used in hyperprolactinemia

20. Warfarin is contraindicated in

21. Anti - rheumatic agent also used for Chron's disease

22. Drug used in exoerythrocytic cycle of malaria

23. Increased risk of developing cataracts

24. Prevention of cyclophosphamide induced hemorrhagic cystitis

25. Allopurinol treats chronic gout by decreasing uric acid production by inhibiting

26. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism

27. The elimination of drug that occurs before it reaches the systemic circulation

28. Intermediate acting glucocorticoids

29. DOC for herpes and its MOA

30. MOA for benzodiazepines

31. SE for ticlopidine

32. Secondary amines that have less sedation and more excitation effect

33. Heparin (PTT) increases activity of

34. Common side effect of hypnotic agents

35. PTU (propylthiouracil) MOA

36. Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA

37. Reason ergot alkaloids are contraindicated in pregnancy

38. Activation of these receptors open K+ ion channels to cause membrane hyperpolarization

39. IV Drug used Hypertensive Crisis

40. Treatment of resistant pseudomembranous colitis

41. Drugs that can be used for infantile spasms

42. Antipsychotic having the strongest autonomic effects

43. Dose may need to be increased during pregnancy or with Ocs due to increased TBG in plasma

44. Agent that inhibits alcohol dyhydrogenase and its clinical use

45. Used for SIADH

46. Agent to treat torsades de pointes

47. This agent used to treat dry mouth in Sj

48. Barbiturate used for the induction of anesthesia

49. The most toxic organophosphate

50. Antiestrogen drugs used for fertility and breast cancer respectively