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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion
Nortriptyline - Desipramine
Fentanyl
Side - effect profile and prior pt response
Prostaglandin PGF2a
2. Agent with long duration of action and is most likely to cause histamine release
Labetalol and carvedilol
Halothane
Tubocurarine
Tetracycline
3. Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage - cardiac arrhythmias - and myocardial infarction
Cocaine
Temazpam - trizolam - flurazepam
Amphetamines
Alkalinize urine - dialysis
4. SE of acetaminophen
Amoxapine
Hepatotoxicity
Infliximab
Dexrazoxane
5. Newer alpha 2 agonist (apraclonidine and brimonidine) treat glaucoma by acting to
Cutaneous flush
Reduce aqueous secretion
Protamine sulfate
Aspirin
6. Aminoglycoside that is least ototoxic
Increased thromboembolic events
Streptomycin
Calcium channel blockers
Yohimbine
7. Most inhaled anesthetics SE
Decrease arterial blood pressure
Aspirin irreversibly inhibits cyclooxygenase
Haloperidol
Beta blockers
8. Selective Alpha 2 blocker used for impotence (controversial effectiveness)
PCP
Yohimbine
Tamoxifen
Rhabdomyolysis
9. Anti - seizure medication also used in the prevention of migraines
Sotalol
Selegiline
Valproic acid
Bone marrow and teeth discoloration for children under 8 years of age
10. SE of amrinone
Adenosine
Thrombocytopenia
Diazepam
Diazepam
11. Anti - thyroid drugs
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Dopamine blockade
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Thioamides - iodides - radioactive iodine - and ipodate
12. MOA of quinolones
Inhibit DNA gyrase
Acetazolamide
Sinus tachycardia and serious arrhythmias
Raloxifene (SERM- selective estrogen receptor modulator)
13. MOA of repaglinide
Valproic acid
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Flumazenil
Aspirin
14. MOA of aspirin
Ethanol or fomepizole
Irreversibly blocking cyclooxygenase
Sodium channel blockade
'On - off - phenomenon'
15. SE of niacin
Nesiritide (Natrecor)
Cutaneous flush
Mast cell stabilizer
Buspirone
16. Antidote used for heparin overdose
Streptokinase
Protamine
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Classic
17. Class III antiarrhythmic that exhibits properties of all 4 classes
Ipratropium
Geriatrics due to its CNS (depression) effects
Drug induced Parkinsonism
Amiodarone
18. These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB)
Tolerance
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Clindamycin
IV administration
19. MOA action of cromolyn
Mast cell stabilizer
G- CSF (filgrastim) and GM- CSF (sargramostim)
Thioridazine
Fomepizole
20. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Buprenorphine
Allopurinol
Niacin
Naltrexone
21. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration
nephro and ototoxicity
Cartilage damage
Carmustine (BCNU) and lomustine (CCNU)
Nitrous oxide
22. Antidepressant also used for sleep that causes priapism
Amrinone and milrinone
Indomethacin
Trazodone
Angiotensin receptor
23. Thyroxine dose may need to be increased in hypothyroid patient during pregnancy because
Amrinone and milrinone
Estogens increase maternal TBG
Ethanol
Anterograde amnesia
24. Only direct acting agent that is very lipid soluble and used in glaucoma
Letrozole - anastrozole
Pilocarpine
Diclofenac - ketoralac
Disulfiram - like reaction
25. The most toxic organophosphate
Flumazenil
Parathion
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Desflurane
26. Common mechanism by which overdose result in death
Iodide salts
Ganciclovir
Depression of medullary and cardiovascular centers
Ipratropium
27. Fluoride released by metabolism of this inhaled anesthetic may cause renal insufficiency
Methoxyflurane
SSRI's - bupropion - and venlafaxine
Naloxone
Vincristine
28. Inhaled anesthetic that may sensitize the myocardium to arrhythmogenic effects of catecholamines and has produced hepatitis
Miosis and constipation
Tricyclic antidepressants (TCA)
Halothane
Adenosine
29. Neurologic SE of benzodiazepines
Warfarin (PT)
Ticlopidine
Chemical esophagitis
Anterograde amnesia
30. Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure
inhibits HMG COA reductase
Timolol (nonselective) - betaxolol (selective)
Gastric ulcers and GI Bleeding
Fomepizole
31. Common SE of spironolactone
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Gynecomastia and hyperkalemia
Thioridazine
32. Anticancer drug also used in RA - produces acrolein in urine that leads to hemorrhagic cystitis
Benztropine - trihexyphenidyl
pregnancy and with K+
Cyclophosphamide
Administration of Vit. B6 (pyridoxine)
33. The fraction of administered dose of a drug that reaches systemic circulation
Bioavailability (F)
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Tolerance
Prostaglandin PGF2a
34. SE of beta blockers
Succinylcholine
Work at early distal convoluted tubule
Niacin
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
35. Agent that inhibits alcohol dyhydrogenase and its clinical use
Letrozole - anastrozole
Metformin
Meperidine
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
36. Clinical response that may fluctuate in tx of Parkinson's dx
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37. Non - benzodiazepine used for sleep
Epinephrine
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Zolpidem
Nondepolarizing Neuromuscular Blockers
38. Agent that is teratogen and causes a fetal syndrome
Ethanol
Leucovorin
Methoxyflurane
Ketanserin cyproheptadine - and phenoxybenzamine
39. Uses of bisphosphonates
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40. Drugs available in combination with metformin
Glyburide - glipizide - and rosiglitazone
Propranolol
Diazepam
Digibind
41. What do alpha cells in the pancreas produce?
Aminocaproic acid
Bradykinin and histamine
Glucagon
Adenosine
42. Vascular effects of metformin
Liver toxicity - increased serum cholesterol
Decreased micro and macro vascular disease
Abciximab - tirofiban and eptifibatide
Calcium channel blockers
43. A hormone whose MOA utilizes transmembrane receptors
Pyridostigmine
Ephedrine
Urinary acidification and activated charcoal or continual nasogastric suction
Insulin
44. Anti - viral agents associated with Stephen Johnson syndrome
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Postsynaptic Mu receptors
Methotrexate
Nevirapine - amprenavir
45. Carbonic anhydrase inhibitor
Morphine
Acetazolamide
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Ticlopidine
46. SSRI with long T1/2 and can be administered once weekly for maintenance - not acute tx
Midodrine
Nandrolone - oxymetholone - and oxandrolone
Adenosine
Fluoxetine
47. Captopril and enalapril (- OPRIL ending) are
ACE inhibitors
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Carvedilol
Thiopental
48. W/D from this drug causes anxiety and mental discomfort
Nicotine
Methadone
Interleukin 11 (oprelvekin)
Ketamine
49. Concentration in the plasma times (clearance divided by bioavailability)
Drug induced Parkinsonism
Somatostatin
Maintenance dose (Cp*(CL/F))
L- thyroxine (T4)
50. Thiazolidinediones
Tolerance
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
SSRI's - bupropion - and venlafaxine
Rheumatic disease