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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Most frequent route of metabolism
Penicillamine
Hepatic enzymes
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Ethanol
2. Withdrawal from this drug causes lethargy - irritability - and headache
Caffeine
Prostaglandin PGF2a
Propranolol
Valproic acid
3. Antihistamine that can be used for anxiety and insomnia and is not addictive
Increasing afterload and tissue perfusion declines
hydroxyzine (Atarax)
Sulfonamides
Atenolol - acebutolol - and metoprolol
4. MOA of thiazide diuretics
Inhibit Na+/Cl - cotransport
Valproic acid
Phentolamine
Vancomycin - infusion at a slow rate and antihistamines
5. Treatment for TB patients (think RIPE)
Etidronate
Bioavailability (F)
Rescue therapy
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
6. SE of penicillamine
Aplastic anemia and renal toxicity
Dextroamphetamines and methamphetamine
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Amoxapine
7. Agent with long duration of action and is most likely to cause histamine release
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Thick ascending limb
Tubocurarine
Decrease arterial blood pressure
8. SE of mirtazapine
Reduce inhibition - suppress anxiety - and produce relaxation
Ipratropium
Prolongs QT interval
Liver toxicity - increased serum cholesterol
9. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Allopurinol
Bupropion
Pyridostigmine
Gabapentin
10. Important in muscle and adipose tissue for glucose transport across muscles and TG storage by lipoprotein lipase activation
Scotch tape technique and mebendazole
GLUT 4
Phenoxybenzamine
LSD
11. Drug of choice for leprosy
Leucovorin
Dapsone - rifampin and clofazimine combination
Testosterone
Glucagon
12. Chelating agent used in Wilson's disease
Halothane
Dapsone - rifampin and clofazimine combination
Penicillamine
Magnesium sulfate
13. Some side effects of corticosteroids
Hepatic enzymes
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Cevimeline
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
14. Osmotic diuretic used to treat increased intracranial pressure
Dipyridamole
Mannitol
Tricyclic antidepressants (TCA)
Excessive CNS stimulation (seizures)
15. SSRI indicated for premenstrual dysphoric disorder
Alprazolam
Flumazenil
Fluoxetine (Sarafem)
Nitroglycerin sublingual tablets
16. Increased risk of developing cataracts
Bioavailability (F)
Glucagon
Quetiapine
Block voltage - dependent sodium channels
17. MOA of class III antiarrhythmics
N- acetylcysteine (Mucomyst)
Rhabdomyolysis
Potassium channel blockers
Prilocaine
18. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Aspirin
Protamine
Ethanol - Barbiturates - and Benzodiazepines
Thioridazine
19. Agents that block L- type calcium channel
Calcium channel blockers
Valproic acid
Aspirin
Maintenance dose (Cp*(CL/F))
20. Agent used for acute muscle spasm
Cyclobenzaprine
High therapeutic index
Ethanol
Atracurium
21. Inhalant anesthetics
Mifepristone
NO - chloroform - and diethyl ether
Meperidine
Acyclovir; incorporated into viral DNA and chain termination
22. Antidote used for carbon monoxide poisoning
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Amphetamines
100% O2 and hyperbaric O2
Dantrolene
23. Agents having higher sedation and antimuscarinic effects than other TCA's
Work at early distal convoluted tubule
Tinnitus - GI bleeding
Carbenicillin - piperacillin and ticarcillin
Tertiary amines
24. 'Date rape drug'
Desflurane
Carbidopa
Flunitrazepam (rohypnol)
Insulin glargine
25. Vitamin given with calcium to ensure proper absorption
Calcium channels
Vitamin D
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Aspirin - Nitrates - CCB - and Beta blockers
26. These beta blockers are less lipid soluble
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Oral
Ezetimibe (Zetia)
Acebutolol and atenolol
27. Antidote useful for some drug induced Torsade de pointes
Magnesium sulfate
Atenolol - acebutolol - and metoprolol
Theophylline
Nesiritide (BNP)
28. The selective agents loose their selectivity at
Meperidine
Methotrexate
high doses
Infliximab
29. Long acting beta 2 agonist used in asthma
Rheumatic disease
Isoflurane
GLUT 4
Salmeterol
30. Regimen used for non - Hodgkin's lymphoma
Adenosine
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Increase the DURATION of GABA- mediated chloride ion channels
Amphetamines
31. Antiprogestin used as potent antagonist of GC receptor
Muscarinic blockers
Fluoxetine (Sarafem)
Nitrites
Mifepristone
32. Side effects seen with tricyclic antidepressants
Risperidone
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Adrenal suppression and weaning slowly - respectively
Demeclocycline
33. Second generation sulfonylurea
Glyburide - glipizide - glimepiride - etc.
Morphine and fentanyl
GLUT 2
Neutropenia and agranulocytosis
34. Antipsychotics that reduce positive symptoms only
Cyanocobalamin (Vit B12)
Older antipsychotics
Nifurtimox
Minocycline
35. Diuretic used to antagonize aldosterone receptors
Hypertension
Betamethasone and dexamethasone
Spironolactone
Nifedipine
36. Antifungal agent used for inhibition of all gonadal and adrenal steroids
Ketoconazole
Aspirin irreversibly inhibits cyclooxygenase
Nitrous oxide
nephro and ototoxicity
37. These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB)
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Bleomycin
Older antipsychotic agents - D2 receptors
Hypercalcemia
38. H1 antagonist used in motion sickness
LD50
Dimenhydrinate - meclizine - and other 1st generation
sodium polystyrene sulfonate (Kayexalate)
Thioridazine
39. SE for ticlopidine
Neutropenia and agranulocytosis
Prolonged half - life - up to six weeks
Hydration and mercaptoethanesulfonate (MESNA)
Minimum alveolar anesthetic concentration (MAC)
40. Mineralocorticoids
Fludrocortisone and deoxycorticosterone
Clomipramine
Disulfiram
Apraclonidine - brimonidine
41. Interaction with this drug requires dose reduction of 6- MP
Hypercalcemia
Low therapeutic index
Apraclonidine - brimonidine
Allopurinol
42. MOA of metformin
Older antipsychotics
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
St. Anthony's Fire
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
43. This agent regenerates active cholinesterase and is a chemical antagonist used to treat organophosphate exposure
Adrenal suppression and weaning slowly - respectively
Pralidoxime
Yohimbine
SSRI's - bupropion - and venlafaxine
44. Side effect of sotalol
Carboplatin
Beta1 agonists
Acebutolol and atenolol
prolongs QT and PR interval
45. SE of hydroxychloroquine
Retinal destruction and dermatitis
Etidronate
Dipyridamole
Nondepolarizing Neuromuscular Blockers
46. This agent used to treat dry mouth in Sj
Prilocaine
Carbamazepine
Cevimeline
Ipratropium
47. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
Cefixime (3rd) generation
Sumatriptan
Oxybutynin - dicyclomine
Epinephrine
48. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
REM is decreased
Halothane and methoxyflurane
Propranolol
49. Antipsychotic having the strongest autonomic effects
Bromocriptine
Delavirdine - efavirenz - and ribavirin
Thioridazine
Vitamin K or fresh frozen plasma
50. Treatment for opioid addiction
Penicillamine
Beta - blockers such as propranolol
Methadone - followed by slow dose reduction
CNS depressants