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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. MOA of erythromycin
Epinephrine
6- mercaptopurine (6- MP)
Estrogen (HRT- Hormone replacement therapy)
Inhibition of protein synthesis at the 50s subunit of ribosome
2. Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis
Albuterol
Nevirapine - amprenavir
Fluoxetine (Sarafem)
Thioridazine
3. New class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins
Ezetimibe (Zetia)
Alkalinize urine - dialysis
Pentoxifylline
Pamidronate - zoledronate - ibandronate
4. HIV med used to reduce transmission during birth
Esmolol
Cimetidine
AZT (zidovudine)
Valproic acid
5. Antidote used for lead poisoning
Dimercaprol - EDTA
Insulin glargine
Phentolamine
Magnesium sulfate
6. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Atracurium
Rescue therapy
Halothane and methoxyflurane
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
7. Agent used neutropenia especially after chemotherapy
Bethanechol
sodium polystyrene sulfonate (Kayexalate)
Nondepolarizing Neuromuscular Blockers
G- CSF (filgrastim) and GM- CSF (sargramostim)
8. Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)
Morphine
Fluoxetine (Sarafem)
Nephrotoxicity
Flumazenil
9. MOA of quinolones
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Inhibit DNA gyrase
LFT's
Esmolol
10. Beta 1 agonist toxicity
Sinus tachycardia and serious arrhythmias
Flumazenil
Propranolol
Insulin
11. Leads to respiratory depression progressing to coma and death
Adalimumab - infliximab and etanercept
Theophylline
Suramin
Overdose of opioids
12. Drug causing depletion of substance P (vasodilator)
Methadone - followed by slow dose reduction
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Magnesium sulfate
Capsaicin
13. Nonselective alpha - blocking drug - long acting and irreversible - and used to treat pheochromocytoma. Blocks 5- HT - so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis
Inhibit Cytochrome P450 3A4
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
Dopamine blockade
Phenoxybenzamine
14. Antibiotic causing red - man syndrome - and prevention
Vancomycin - infusion at a slow rate and antihistamines
Elderly patients
Celecoxib
Midazolam
15. Non - benzodiazepine used as an anxiolytic
Buspirone
Aminoglutethimide
Erythropoietin
Lithium toxicity
16. 5HT-3 antagonist used in chemotherapeutic induced emesis
Niacin
Ondansetron - granisetron - dolasetron and alosetron
Esmolol
Mivacurium
17. Alpha - glucosidase inhibitor associated with elevation of LFT's
Acarbose
Pregnancy
Hyperuricemia - hypokalemia and ototoxicity
Ezetimibe (Zetia)
18. Cephalosporin causes kernicterus in neonates
Atropine - homatropine - C1208 tropicamide
Severe hypertension
LSD
Ceftriaxone or cefuroxime
19. These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB)
Cartilage damage
Cholinesterase inhibitors
Carmustine (BCNU) and lomustine (CCNU)
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
20. Inhibit angiotensin - converting enzyme (ACE)
Prednisone - methylprednisolone - prednisolone - and triamcinolone
ACE inhibitors
Acetazolamide
Nonselective Muscarinic Antagonists
21. Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Amantadine
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
Diazepam
22. Initial DMARD of choice for patients with RA
Amoxicillin
Epinephrine - dipivefrin
Methotrexate
Ceftriaxone
23. Aromatase inhibitor used in breast cancer
Letrozole - anastrozole
Rhabdomyolysis and Hepatotoxicity
Heparin induced thrombocytopenia (HIT)
Lupus - like syndrome
24. Mineralocorticoids
Heroin - morphine - oxycodone - meperidine and fentanyl
Prolongs QT interval
Beta - blockers such as propranolol
Fludrocortisone and deoxycorticosterone
25. Population group especially sensitive to side effects of antidepressants
Calcium
Tetracaine and bupivacaine
Atenolol - acebutolol - and metoprolol
Elderly patients
26. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Naltrexone
Parathion
Allopurinol
Timolol
27. Site of action of loop diuretics
Sodium bicarbonate
Thick ascending limb
Rescue therapy
LSD
28. Where are beta cells found in the pancreas?
Islets of Langerhans
Affect calcium - potassium - and sodium channels
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Cyanide toxicity treated with sodium thiosulfate
29. COX 2 inhibitors should be used cautiously in pts with
Acetazolamide
Nephrotoxicity
Pre - existing cardiac or renal disease
Sulfasalazine
30. Cystitis - postoperative bladder spasms - or incontinence
Hyperkalemia
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Repaglinide
Oxybutynin - dicyclomine
31. Drug of choice for leprosy
Dobutamine and dopamine
Ipodate
Drug induced Parkinsonism
Dapsone - rifampin and clofazimine combination
32. These agents are used as antitussive
sulfamethoxazole/ trimethoprim
Aspirin
Cocaine 'super - speed'
Dextromethorphan - Codeine
33. Anti - emetics used in association with anti - cancer drugs that are 5- HT3 (serotonin receptor subtype ) antagonists
Rheumatic disease
Selegiline
Odansetron - granisetron
Atropine
34. Selective Alpha 1 blocker used for hypertension - BPH - may cause first dose orthostatic hypotension
Prazosin - terazosin - doxazosin
Tricyclic antidepressants (TCA)
Work at early distal convoluted tubule
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
35. Target plasma concentration times (volume of distribution divided by bioavailability)
Inhibit dihydropteroate synthase
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Kidneys
Loading dose (Cp*(Vd/F))
36. Non - benzodiazepine used for sleep
First generation due to being more lipid - soluble
Phenobarbital
Zolpidem
Cyanocobalamin (Vit B12)
37. Beta blockers work in CHF by
Deferoxamine
Noncompetitive antagonist
Reducing progression of heart failure (never use in acute heart failure)
Sulfonamides
38. Block cardiac adverse effects of thyrotoxicosis such as tachycardia - inhibits the conversion of T4 to T3
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
N- acetylcysteine
Beta - blockers such as propranolol
Dopamine blockade
39. Distribution of histamine receptors H1 - H2 - and H3
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Sermorelin
Fluoxetine
Specificity
40. Bronchodilation in asthma and COPD
nephro and ototoxicity
Tamsulosin
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Ipratropium
41. SE of imipenem
Glucagon
Seizures
Flunitrazepam (rohypnol)
Increase the DURATION of GABA- mediated chloride ion channels
42. Antidote for methotrexate toxicity
Leucovorin
Letrozole - anastrozole
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Caffeine
43. Generation of antihistamine that has the most CNS effects
First generation due to being more lipid - soluble
L- asparaginase
Maintenance dose (Cp*(CL/F))
Decreases protein synthesis by inhibiting 30S ribosome
44. Anticoagulant of choice in pregnancy
Flumazenil
Neostigmine
Carbidopa
Heparin
45. Class of drugs that may cause cross - sensitivity with thiazide diuretics
Red urine discoloration
Pindolol and acebutolol
Sulfonamides
Octreotide
46. Treatments available for nicotine addiction
Increasing afterload and tissue perfusion declines
Beta -1 selective blockers
Patches - gum - nasal spray - psychotherapy - and bupropion
First order kinetics
47. Diuretic used for mountain sickness and glaucoma
Acetazolamide
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Agranulocytosis
Fexofenadine - loratadine - and cetirizine
48. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation
Olanzapine - aripiprazole - and sertindole
Glucocorticoids
Phenoxybenzamine
Aplastic anemia and renal toxicity
49. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Bupropion
Respiratory failure
Partial agonist
Succinylcholine
50. CCB contraindicated in CHF
Thiopental
Verapamil
Efficacy
6- mercaptopurine (6- MP)