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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Drug causes teeth discoloration
Severe hypertension
Beta blockers
Ipodate
Tetracycline
2. Drugs of choice for generalized tonic - clonic and partial seizures
Valproic acid and Phenytoin
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Cefixime (3rd) generation
Succinylcholine
3. CCB with predominate effect on arteriole dilation
LSD
Seizures
Nifedipine
Iron deiodinates thyroxine
4. Antidote for salicylate intoxication
5- flouracil (5- FU)
Antithrombin 3
Alkalinize urine - dialysis
Monamine oxidase inhibitors
5. Inducers of Cytochrome P450 (CYP450)
Barbiturates - phenytoin - carbamazepine - and rifampin
Adenosine
GLUT 2
Oxidation - reduction - hydrolysis
6. The elimination of drug that occurs before it reaches the systemic circulation
Thyroid and steroid hormones
Specificity
First pass effect
Megaloblastic anemia
7. Ultra long acting insulin - has over a day duration of action
Amantadine
Glargine (Lantus) - detemir
Decreased micro and macro vascular disease
L- dopa
8. The most common type of drug interaction of sedative hypnotics with other depressant medications
B- blockers
Thrombocytopenic purpura - and CINCHONISM
Additive CNS depression
Pregnancy
9. The most common neurologic abnormality in chronic alcoholics
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Decreases protein synthesis by inhibiting 30S ribosome
Methotrexate
Nitrites
10. Drug of choice for leprosy
Dapsone - rifampin and clofazimine combination
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
Methadone - followed by slow dose reduction
Buspirone
11. Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons
Phenylephrine
Clozapine
Ascending pathways
Aplastic anemia and acute hepatic failure
12. Drug used in cancer therapy causes Cushing - like symptoms
Prednisone
Prolonged half - life - up to six weeks
Patches - gum - nasal spray - psychotherapy - and bupropion
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
13. Drugs of choice for status epilepticus
Diclofenac - ketoralac
Heparin induced thrombocytopenia (HIT)
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Odansetron - granisetron
14. Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs
Metronidazole
Rifampin
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Chlordiazepoxide and Diazepam
15. Agent for pernicious anemia
Morphine and fentanyl
Bromocriptine
Cyanocobalamin (Vit B12)
Valproic acid - carbamazepine - phenytoin and gabapentin
16. MOA of cisplatin
Atropine - homatropine - C1208 tropicamide
Theophylline
Minocycline
Alkylating agent
17. Agent used for megaloblastic anemia (but does Not reverse neurologic symptoms) and decrease neural tube defects during pregnancy
Nevirapine - amprenavir
Benztropine - trihexyphenidyl
Propranolol
Folic acid
18. NSAID also available as an ophthalmic preparation
Thioridazine
Increased thromboembolic events
Diclofenac - ketoralac
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
19. This is combined with L- dopa - inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L- dopa and allows for fewer SE's (GI distress - postural hypotension - and dyskinesias)
Protease inhibitors
Carbidopa
Carbenicillin - piperacillin and ticarcillin
Fluoxetine (Sarafem)
20. NSAID used in gout
Cephalosporins
Apraclonidine - brimonidine
Hypertrichosis
Indomethacin
21. SE of imipenem
Seizures
Opioid Analgesics
Penicillamine
Magnesium sulfate
22. Potassium sparing diuretics inhibit
Lepirudin
Morphine and fentanyl
Na+/K+ exchange
Acetazolamide
23. MOA of corticosteroids
inhibit phospholipase A2
Alprazolam
Leuprolide
Pre - existing cardiac or renal disease
24. Antidote used for digitalis toxicity
Hypertrichosis
Increases concentration of Digoxin
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Insulin
25. Where are beta cells found in the pancreas?
Oral
Islets of Langerhans
Hepatic toxicity
Tertiary amines
26. These agents are congeners of Amphetamine
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27. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction
Aspirin
Meperidine
Midazolam
Tinnitus - GI bleeding
28. Beta blockers partial agonist activity (intrinsic sympathomimetic activity) cause some bronchodilation and may have an advantage in treating patients with asthma
Class IC (flecainide - propafenone - moricizine)
Pindolol and acebutolol
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Sermorelin
29. Direct vasodilator of arteriolar smooth muscle
Folic acid
Hydralazine
Calcium channel blockers
Buspirone
30. Prolonged exposure to this inhaled anesthetic may lead to megaloblastic anemia
Phenytoin
Ability to cross the placenta
Nitrous oxide
Succinylcholine
31. Strength of interaction between drug and its receptor
Mirtazapine
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Affinity
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
32. Drugs used in the management of angina
Carbenicillin - piperacillin and ticarcillin
Aspirin - Nitrates - CCB - and Beta blockers
Neostigmine
Leuprolide
33. The fraction of administered dose of a drug that reaches systemic circulation
Nondepolarizing Neuromuscular Blockers
Bioavailability (F)
Gingival hyperplasia
Finasteride (Proscar and Propecia respectively)
34. Agent having no effect on D2 receptors - blocks D4 - reserved for resistant schizophrenia - and can cause fatal agranulocytosis
Esmolol
Methadone
Adenosine
Clozapine
35. Heparin (PTT) increases activity of
Lupus - like syndrome
Antithrombin 3
Potassium channel blockers
Glucagon
36. MOA of class III antiarrhythmics
Cocaine and benzocaine
Phenytoin
Potassium channel blockers
Aldehyde dehydrogenase
37. Converted to more active form DHT by 5 alpha - reductase
Testosterone
Propranolol
Physostigmine
Tubocurarine
38. HMG CoA reductase inhibitors are contraindicated in
Gynecomastia and hyperkalemia
Dry cough - hyperkalemia
Fluphenazine and haloperidol
Pregnancy
39. SSRI indicated for premenstrual dysphoric disorder
Venlafaxine
Disulfiram
Valproic acid
Fluoxetine (Sarafem)
40. Anti - viral with a dose limiting toxicity of pancreatitis
Halothane
REM is decreased
Didanosine
Somatostatin
41. SE for ticlopidine
Hyperuricemia - hypokalemia and ototoxicity
Dexrazoxane
Neutropenia and agranulocytosis
Uterine contractions
42. Removal of PCP may be aided
B- blockers
Urinary acidification and activated charcoal or continual nasogastric suction
L- thyroxine (T4)
Prednisone - methylprednisolone - prednisolone - and triamcinolone
43. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration
Dimercaprol - EDTA
Labetalol and carvedilol
Verapamil
Nitrous oxide
44. IV barbiturate used as a pre - op anesthetic
Beta - blockers such as propranolol
Desmopressin (DDAVP)
Thiopental
Angiotensin receptor
45. Interaction with this drug requires dose reduction of 6- MP
Allopurinol
Verapamil
Succinylcholine
CNS stimulation; GI upset
46. Some side effects of corticosteroids
Amiodarone
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Digibind
Pamidronate - zoledronate - ibandronate
47. Non - benzodiazepine used as an anxiolytic
Buspirone
Aspirin - metoprolol
Amitriptyline
B- blockers
48. Alpha 1selective blockers
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Streptokinase
Tamsulosin
Amoxapine
49. This may enhance activity of local anesthetics
Potential for development of Reye's syndrome
Fluoxetine
Hyperkalemia
Dexrazoxane
50. Major effect of benzodiazepines on sleep at high doses
Nefazodone
Nitrous oxide
Theophylline
REM is decreased