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USMLE/COMLEX Step 1 Pharmacology One Liners
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Subjects
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health-sciences
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usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
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study here
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Peptide drug used to treat CHF
Letrozole - anastrozole
Methadone - followed by slow dose reduction
Carbidopa
Nesiritide (BNP)
2. Used for SIADH
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Olanzapine - aripiprazole - and sertindole
Partial agonist
Demeclocycline
3. Intermediate acting glucocorticoids
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Ethanol
Lithium toxicity
Abstinence syndrome
4. SSRI indicated for premenstrual dysphoric disorder
Efficacy
Fluoxetine (Sarafem)
Beta1 agonists
Amoxapine
5. Readily detected markers that may assist in diagnosis of the cause of a drug overdose include
Celecoxib and rofecoxib
Work at early distal convoluted tubule
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Hypertensive crisis
6. Antipsychotics that reduce positive symptoms only
Older antipsychotics
Fomepizole
Fentanyl
REM is decreased
7. Diuretics work in CHF by
Radioactive iodine
Hydralazine
Reducing preload
Primaquine
8. Selective alpha agonists that decreases aqueous secretion
Apraclonidine - brimonidine
Beta1 agonists
Nitroprusside
Aminocaproic acid
9. Antidepressants with no effect on BP - no sedation
Ethosuximide and valproic acid
Mifepristone (RU-486)
5- flouracil (5- FU)
SSRIs
10. Common SE of spironolactone
Ethanol - Barbiturates - and Benzodiazepines
Cartilage damage
ACE inhibitors
Gynecomastia and hyperkalemia
11. Antidote for methotrexate toxicity
Fomepizole
Nephrotoxicity
Metronidazole
Leucovorin
12. Good hypnotic activity with less CNS SE than most benzodiazepines
Cytomel
Propranolol
Zolpidem - zaleplon
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
13. May protect against doxorubicin toxicity by scavenging free radicals
Temazpam - trizolam - flurazepam
Aminocaproic acid
Dexrazoxane
Full agonist
14. Epinephrine is often mixed with a local anesthetic to
Rescue therapy
Acetazolamide
Reduce the loss from area of injection
Cevimeline
15. Used intravenously for acute arrhythmias during surgery
Esmolol
ACE inhibitors
Thrombocytopenia
Monamine oxidase inhibitors
16. Nitrate free intervals are needed due to
Flumazenil
Hypertrichosis
Beta -1 selective blockers
Tolerance
17. Four main actions of NSAIDS
Deferoxamine
Nandrolone - oxymetholone - and oxandrolone
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Suramin
18. Drugs of choice for absence seizures
Venlafaxine
Phenytoin
Ethosuximide and valproic acid
Meperidine
19. DOC for herpes and its MOA
Rhabdomyolysis and Hepatotoxicity
Steroids
Hypertension
Acyclovir; incorporated into viral DNA and chain termination
20. Reversal of blockade by neuromuscular blockers
Cholinesterase inhibitors
Arteries and veins
Decrease arterial blood pressure
Acyclovir; incorporated into viral DNA and chain termination
21. '5HT-1d agonist used for migraine headaches '
Spironolactone
Miosis and constipation
Sumatriptan - naratriptan - and rizatriptan
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
22. CCB contraindicated in CHF
Edrophonium
Vincristine
Verapamil
Ethinyl estradiol and mestranol
23. Agent used for neurological deficits in megaloblastic anemia
Skeletal muscle tremor - tachycardia
Didanosine
5-7 days
Vitamin B12
24. Antidote for tissue plasminogen activator (t - PA) - streptokinase
Naloxone (IV) - naltrexone (PO)
Spasmolytic drugs
Aminocaproic acid
Insulin
25. DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics
Glargine (Lantus) - detemir
Midodrine
Prostaglandin PGF2a
Dantrolene
26. Treatment of motion sickness
Scopolamine - meclizine
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Rheumatic disease
Nicotine
27. MOA of repaglinide
Demeclocycline
Prinzmetal's angina
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Diethylstilbestrol (DES)
28. Non - selective Beta - blocker also used for migraine prophylaxis
Spasmolytic drugs
inhibit phospholipase A2
Propranolol
Minoxidil
29. Ultra long acting insulin - has over a day duration of action
Odansetron - granisetron
Glargine (Lantus) - detemir
Inhibit Cytochrome P450 3A4
Epinephrine
30. SE of INH
Ketanserin cyproheptadine - and phenoxybenzamine
Edrophonium
Clonidine - and methyldopa
Peripheral neuritis and hepatitis
31. Fibrates (gemfibrozil) increase activity of
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Bradykinin and histamine
Carvedilol
Lipoprotein lipase
32. DOC for Legionnaires' disease
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Erythromycin
Sodium channel blockers
Sulfasalazine
33. Inhalant anesthetics
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Valproic acid
C- peptide
NO - chloroform - and diethyl ether
34. Most inhaled anesthetics SE
Therapeutic index
Decrease arterial blood pressure
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Reduce the loss from area of injection
35. MOA of drug or foods (grapefruit juice) that increase statin effect
Skeletal muscle tremor - tachycardia
Inhibit Cytochrome P450 3A4
Dextromethorphan - Codeine
Xanthine oxidase
36. SE of phenytoin
Ferrous sulfate
Insulin
Gingival hyperplasia
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
37. Non - benzodiazepine used as an anxiolytic
Celecoxib
Buspirone
Probenecid and sulfinpyrazone
Terbutaline
38. Drug used in exoerythrocytic cycle of malaria
Neutro - leuko and thrombocytopenia
lispro insulin - aspart insulin - glulisine insulin
Primaquine
Lithium
39. Leads to respiratory depression progressing to coma and death
pregnancy and with K+
Glucagon
N- acetylcysteine
Overdose of opioids
40. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure
Nitroglycerin sublingual tablets
Venlafaxine
Thioamides - iodides - radioactive iodine - and ipodate
Somatrem
41. Long acting glucocorticoids
Meperidine
Betamethasone and dexamethasone
Fluoxetine
Timolol (nonselective) - betaxolol (selective)
42. Toxicities include nephrotoxicity and ototoxicity - leading to a severe interaction with aminoglycosides
Cisplatin
Inhibit Na+/Cl - cotransport
Zafirlukast and montelukast
Chlorpropamide
43. Barbiturates may precipitate this hematologic condition
Regular (Humulin R)
Barbiturates - phenytoin - carbamazepine - and rifampin
Acute intermittent porphyria
Low - potency typical antipsychotics and clozapine
44. Used for hairy cell leukemia; it stimulates NK cells
Cimetidine
Pulmonary embolism and DVT
Interferon alpha
LFT's
45. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion
Side - effect profile and prior pt response
Carvedilol
Cutaneous flush
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
46. Used for Cushing's syndrome (increased corticosteroid)
Nondepolarizing type antagonists
Dexamethasone suppression test
Methotrexate
Nondepolarizing Neuromuscular Blockers
47. Somatotropin (GH) analog used in GH deficiency (dwarfism)
Xanthine oxidase
Gabapentin
Somatrem
Hypoglycemia
48. Chronic high dose abuse of nicotine leads to
Cimetidine
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Cp
Liver enzyme INDUCTION
49. Window between therapeutic effect and toxic effect
Temazpam - trizolam - flurazepam
Therapeutic index
Edrophonium
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
50. Cause dizziness - tachycardia - hypotension - and flushing
Gynecomastia hyperkalemia - and impotence
Administration of Vit. B6 (pyridoxine)
Potassium channel blockers
Organic nitrites
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