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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Agent used neutropenia especially after chemotherapy






2. Anticancer drug also used in RA - produces acrolein in urine that leads to hemorrhagic cystitis






3. Two toxicities of aminoglycosides






4. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively






5. Structurally related to acetylcholine - used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation






6. Ultra long acting insulin - has over a day duration of action






7. Different steps of Phase I






8. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure






9. Anti - androgen used for hirsutism in females






10. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)






11. Cutaneous flush and be reduced by pretreatment with






12. Beta 1 agonist toxicity






13. Used for hairy cell leukemia; it stimulates NK cells






14. CCB are DOC for






15. Selectivity of a drug for its receptor






16. MOA of loop diuretics






17. Anti - androgen used for prostate cancer






18. Sedation is a common side effect of these drugs - they lower seizure threshold - uses include BAD - acute panic attacks - phobias - enuresis - and chronic pain and their overdose can be deadly






19. Newer atypical antipsychotic used for bipolar disorder - known to cause weight gain - and adversely affect diabetes






20. Opioid available trans - dermally






21. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property






22. Associated with an increased incidence of cataracts in patients treated for glaucoma






23. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)






24. SE of salicylates






25. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients






26. Common SE of tamoxifen and raloxifene






27. Peakless ling acting insulin






28. Routes of administration of heparin






29. Lithium is associated with this congenital defect






30. This is combined with L- dopa - inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L- dopa and allows for fewer SE's (GI distress - postural hypotension - and dyskinesias)






31. Anti - seizure drugs used also for pain of neuropathic orgin






32. Potassium sparing diuretics inhibit






33. SE of amrinone






34. Regimen used for non - Hodgkin's lymphoma






35. DOC for tx of pseudomembranous colitis






36. Interaction with this drug requires dose reduction of 6- MP






37. These agents are used as antidiarrheal






38. Agent used to treat MI and to reduce incidence of subsequent MI






39. Almost all local anesthetics have this property and sometimes require the administration of vasoconstrictors (ex. Epinephrine) to prolong activity






40. A hormone whose mechanism of action (MOA) utilizes intracellular receptors






41. Treatment of choice for organophosphate overdose






42. DOC for Legionnaires' disease






43. ADH agonist used for pituitary diabetes insipidus






44. Anti - viral with a dose limiting toxicity of pancreatitis






45. Anti - estrogen used for estrogen receptor + breast cancer






46. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)






47. Antidote used for methanol and ethylene glycol






48. Some side effects of corticosteroids






49. Median effective dose required for an effect in 50% of the population






50. Beta 1 agonists used in acute CHF