SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Vitamins containing iron should Not be taken simultaneously with levothyroxine because
Iron deiodinates thyroxine
Tamsulosin (Flomax)
Tolerance
Prazosin - terazosin - doxazosin
2. Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure
ACE inhibitors
Fomepizole
Phase I
Cartilage damage
3. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
Fluoxetine
Log - kill hypothesis
Tamsulosin
Estrogen (HRT- Hormone replacement therapy)
4. Route of administration of warfarin
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Fomepizole
Oral
First pass effect
5. Names of three bisphosphonates available IV
Yohimbine
Marijuana
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Pamidronate - zoledronate - ibandronate
6. SE of demeclocycline
Gingival hyperplasia
Calcium
Islets of Langerhans
Bone marrow and teeth discoloration for children under 8 years of age
7. '5HT-1d agonist used for migraine headaches '
Glucocorticoids
Reduce aqueous secretion
Sumatriptan - naratriptan - and rizatriptan
Nateglinide
8. Facilitates GABA presynaptic inhibition
C- peptide
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Hepatic toxicity
Diazepam
9. DOC for Legionnaires' disease
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Erythromycin
Delavirdine - efavirenz - and ribavirin
Metrifonate
10. CCB with predominate effect on arteriole dilation
Mechlorethamine
Nifedipine
Fentanyl
Aminocaproic acid
11. SE of HMG COA reductase inhibitors
CNS depressants
Rhabdomyolysis and Hepatotoxicity
Phase I
Neuromuscular blocking drugs
12. Shock due to septicemia or myocardial infarction is made worse by
Arteries and veins
Methadone
Hepatotoxicity
Increasing afterload and tissue perfusion declines
13. Presynaptic Alpha 2 agonist used in HTN - and acts centrally
Yohimbine
Zollinger - Ellison Syndrome
Liver toxicity - increased serum cholesterol
Clonidine - and methyldopa
14. Antidote used for lead poisoning
Pregnancy
Dimercaprol - EDTA
Reducing preload
Meperidine
15. Orthostatic hypotension and QT prolongation
Prolongs QT interval
Neutro - leuko and thrombocytopenia
Low potency phenothiazines and ziprasidone
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
16. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep
Prazosin - terazosin and doxazosin (- AZOSIN ending)
pregnancy and with K+
Antipyretic and analgesic activity
Doxepin
17. MOA of lovastatin (STATIN)
Midazolam
Mivacurium
Beta -1 selective blockers
inhibits HMG COA reductase
18. Anti - seizure medication also used in the prevention of migraines
Calcium channels
Dry cough
Valproic acid
Olanzapine - aripiprazole - and sertindole
19. Site of action for zaleplon and zolpidem
Fluorocarbons and Industrial solvents
Digibind
Phase I
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
20. What do delta cells in the pancreas produce?
Calcitonin (salmon prep)
Valproic acid
Volume of distribution (VD)
Somatostatin
21. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression
Dobutamine
Carboplatin
Buspirone
Propoxyphene
22. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation
Glucagon
Hypertensive crisis
Drug induced Parkinsonism
Dopamine
23. DOC for influenza A
Partial agonist
Cyproterone acetate
Fluoxetine (Sarafem)
Amantadine
24. Antidote for hyperkalemia
sodium polystyrene sulfonate (Kayexalate)
Clomipramine
Positive Comb's test - depression
Nifurtimox
25. Antidote used for organophosphate/anticholinesterase poisoning
Ipratropium
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Tamsulosin
Atropine - pralidoxime (2- PAM)
26. Neurotoxicity with isoniazid (INH) prevented by
Administration of Vit. B6 (pyridoxine)
Carvedilol
Haloperidol or pimozide
Heparin
27. Antidote used for digitalis toxicity
Efficacy
Dexrazoxane
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Tolerance
28. Thiazolidinediones
Cimetidine
NO - chloroform - and diethyl ether
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
Valproic acid and Phenytoin
29. Antidote used for heparin overdose
Seizures
Protamine
Aspirin
Increasing afterload and tissue perfusion declines
30. Site of action of thiazide diuretics
Work at early distal convoluted tubule
ORAL vancomycin
Gingival hyperplasia - nystagmus - diplopia and ataxia
First order kinetics
31. Anti - androgen used for prostate cancer
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Epinephrine - dipivefrin
Nitrous oxide
Flutamide (Eulexin)
32. Treat manifestations of Parkinson's disease and EPS
Glargine (Lantus) - detemir
Gingival hyperplasia
Benztropine - trihexyphenidyl
Thioamides - iodides - radioactive iodine - and ipodate
33. Only direct acting agent that is very lipid soluble and used in glaucoma
Cholinesterase regenerators - pralidoxime
Streptokinase
Pilocarpine
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
34. Mediator of tissue pain - edema - inactivated by ACE - and may be a contributing factor to the development of angioedema
Ticlopidine
Testosterone
Bradykinin
Aplastic anemia and renal toxicity
35. Estrogen mostly used in oral contraceptives (OC)
Ethinyl estradiol and mestranol
Timolol (nonselective) - betaxolol (selective)
ACE inhibitors
Somatostatin
36. DOC for malignant hyperthermia by acting on the sacroplasmic reticulum or skeletal muscle
Uterine contractions
Insulin
Dantrolene
Arteries and veins
37. Agent used for closure of patent ductus arteriosus
Desmopressin (DDAVP)
Indomethacin
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Zero order kinetics
38. Most common SE of fibrates
Respiratory failure
Dobutamine
Rheumatic disease
Nausea
39. Aminoglycosides used with loop diuretics potentiate adverse effect
Ototoxicity
Penicillamine
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
40. SE of penicillamine
Clonidine - and methyldopa
block SLUD (salivation - lacrimation - urination - defecation
Aplastic anemia and renal toxicity
Esmolol
41. Losartan and valsartan block
Angiotensin receptor
Niacin
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Cisplatin
42. Oral antibiotic of choice for moderate inflammatory acne
Letrozole - anastrozole
Peripheral neuritis and hepatitis
Cimetidine
Minocycline
43. Treatment of withdrawal syndrome involves
Cyproheptadine
Etidronate
Midodrine
Long - acting sedative - hypnotic or a gradual reduction of dose - clonidine or propranolol
44. Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias - seizures - respiratory depression - or severe HTN (MI and stroke)
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
45. MOA of class III antiarrhythmics
Potassium channel blockers
Labetalol and carvedilol
Lithium
Tricyclic antidepressants (TCA)
46. Anti - rheumatic agent also used for ulcerative colitis
Sulfasalazine
Lorazepam - oxazepam - and temazepam
Terfenadine and astemizole (have been removed from the market)
NSAIDS
47. Produce mydriasis and cycloplegia
Atropine - homatropine - C1208 tropicamide
Celecoxib and rofecoxib
Protamine
Ketamine
48. Some cell cycle non - specific drugs
Flumazenil
Iron deiodinates thyroxine
Dextromethorphan - Codeine
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
49. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Buprenorphine
Olanzapine - aripiprazole - and sertindole
Thioamides - iodides - radioactive iodine - and ipodate
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
50. Drugs that can be used for infantile spasms
Corticosteroids
Epinephrine
Therapeutic index
Hydroxychloroquine