SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Inhalant anesthetics
Bethanechol
Nadolol
NO - chloroform - and diethyl ether
Phenytoin
2. Most inhaled anesthetics SE
Decrease arterial blood pressure
L- thyroxine (T4)
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Deferoxamine
3. Reason fluoroquinolones are contraindicated in children and pregnancy
Cartilage damage
Capsaicin
L- thyroxine (T4)
Glyburide - glipizide - and rosiglitazone
4. Some cell cycle non - specific drugs
Adalimumab - infliximab and etanercept
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
5. SE seen only in men with administration of ketoconazole
Aplastic anemia and renal toxicity
Gynecomastia
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Serotonin syndrome
6. Alpha - glucosidase inhibitor associated with elevation of LFT's
Acarbose
Inhibit dihydropteroate synthase
Glucagon
Bile acid - binding resins
7. This produces 'dissociative anesthesia' - is a cardiovascular stimulant which may increases intracranial pressure - and hallucinations occur during recovery
Ketamine
Tolerance
Positive Comb's test - depression
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
8. DOC for paroxysmal supraventricular tachycardia (PSVT)
Albuterol
Somatostatin
Oxybutynin - dicyclomine
Adenosine
9. Toxicity of anticholinergics
block SLUD (salivation - lacrimation - urination - defecation
Oxytocin
Enflurane and halothane
Neuromuscular blocking drugs
10. Treatment with cancer chemotherapy at high doses every 3-4 weeks - too toxic to be used continuously
Pulse therapy
Lithium
Clonidine - and methyldopa
Nonselective Muscarinic Antagonists
11. Produce mydriasis and cycloplegia
SEVERE myelosuppression
Atropine - homatropine - C1208 tropicamide
Reducing preload
Streptokinase
12. Antidepressants with no effect on BP - no sedation
Celecoxib and rofecoxib
Nesiritide (BNP)
SSRIs
Nifedipine
13. Antidote used for digitalis toxicity
Echothiophate
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Class IC (flecainide - propafenone - moricizine)
Selective inhibitor of microtubule assembly
14. GABA agonist in the spinal cord
Baclofen
Valproic acid - carbamazepine - phenytoin and gabapentin
Ipratropium
Caffeine
15. Major effect of benzodiazepines on sleep at high doses
Muscarinic blockers
Hallucinations resembling psychosis
REM is decreased
Long acting cholinesterase inhibitors
16. Common toxicities of cisplatin
Sulfonamides
Celecoxib and rofecoxib
Rheumatic disease
Nephro and ototoxicity
17. Inhibitors of CYP450
Nesiritide (BNP)
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Nitrites
Adrenal suppression and weaning slowly - respectively
18. Endogenous insulin contains
Oxybutynin - dicyclomine
Tolerance
Cocaine 'super - speed'
Normal C- peptide
19. Drug used for N. gonorrhea in females
Ceftriaxone
Hydroxychloroquine
Affect calcium - potassium - and sodium channels
Iron deiodinates thyroxine
20. SE of spironolactone
Gynecomastia hyperkalemia - and impotence
Albuterol
Rebound HTN - sedation - dry mouth
Hypertensive crisis
21. Vascular effects of metformin
Allopurinol
Haloperidol
Class IC (flecainide - propafenone - moricizine)
Decreased micro and macro vascular disease
22. Most widely used thyroid drugs such as Synthroid and Levoxyl contain
Acebutolol and atenolol
Cholinesterase inhibitors
L- thyroxine (T4)
Magnesium sulfate
23. Estrogen mostly used in oral contraceptives (OC)
Ethinyl estradiol and mestranol
Esmolol
Testosterone
Malathion
24. MOA of NSAIDS
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
Finasteride (Proscar and Propecia respectively)
Older antipsychotic agents - D2 receptors
Esmolol
25. Antiestrogen drugs used for fertility and breast cancer respectively
Clomiphene and tamoxifen
Glucuronate - acetic acid - and glutathione sulfate
Cocaine and benzocaine
Hyperuricemia - hypokalemia and ototoxicity
26. Some of SSRIs' therapeutic effects beside depression
Interferon alpha
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Patches - gum - nasal spray - psychotherapy - and bupropion
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
27. SE of beta blockers
Sodium channel blockade
Protamine
Atracurium
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
28. TCA with greatest sedation of this group - and marked antimuscarinic effects - used for sleep
Rescue therapy
Nondepolarizing Neuromuscular Blockers
Doxepin
Barbiturates - phenytoin - carbamazepine - and rifampin
29. Aspirin reduces mortality in unstable angina by
Beta blockers
Platelet aggregation inhibition
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
30. MOA of nitrates
Atracurium
Dry cough - hyperkalemia
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Toremifene (Fareston)
31. Anticoagulant of choice in pregnancy
Heparin
Sinus tachycardia and serious arrhythmias
Esmolol
Cardiac anomalies and is contraindicated in pregnancy or lactation
32. Main route of metabolism for benzodiazepines
Cocaine 'super - speed'
Hepatic
Uterine contractions
Epinephrine
33. Lacrimation - rhinorrhea - yawning - sweating - weakness - gooseflesh - nausea - and vomiting - tremor - muscle jerks - and hyperpnea are signs of this syndrome
Inhibition of protein synthesis at the 50s subunit of ribosome
Isoflurane
Abstinence syndrome
Somatostatin
34. MOA of both generations
Muscarinic blockers
L- asparaginase
Maintenance dose (Cp*(CL/F))
Insulin release from pancreas by modifying K+ channels
35. A hormone whose MOA utilizes transmembrane receptors
Zolpidem - zaleplon
Ortho - Evra
Insulin
Naloxone
36. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
Succinylcholine
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Propofol
Rescue therapy
37. Agent used for neurological deficits in megaloblastic anemia
Imipramine
Oral
Vitamin B12
Arginine
38. Drugs used in the management of angina
Fluoxetine (Sarafem)
Tetracycline
Risperidone
Aspirin - Nitrates - CCB - and Beta blockers
39. MOA of AGI's
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Bradykinin
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Mirtazapine
40. Additive effects when Sedative - Hypnotics used in combination with these agents
B- blockers
CNS depressants
Dopamine
Octreotide
41. Route of administration of warfarin
GLUT 2
Oral
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Ortho - Evra
42. Presynaptic Alpha 2 agonist used in HTN - and acts centrally
Clonidine - and methyldopa
Skeletal muscle tremor - tachycardia
Inhibit dihydropteroate synthase
Pamidronate - zoledronate - ibandronate
43. Fibrates (gemfibrozil) increase activity of
Celecoxib
Epinephrine
Lipoprotein lipase
Hypertensive crisis
44. Benzodiazepine receptor antagonist - it accelerates recovery from benzodiazepine overdose
2 to 3 weeks
Naloxone (IV) - naltrexone (PO)
Flumazenil
Didanosine
45. Agent with zero - order kinetics
Insulin
Mirtazapine
Odansetron - granisetron
Ethanol
46. Initial DMARD of choice for patients with RA
Methotrexate
Apraclonidine - brimonidine
Patches - gum - nasal spray - psychotherapy - and bupropion
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
47. Disease caused by excess ergot alkaloids
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
48. Antiglaucoma organophosphate
Clindamycin
Echothiophate
EOS
Ketoconazole
49. Common SE of sulfonylureas - repaglinide - and nateglinide
Dry cough - hyperkalemia
Hypoglycemia
Islets of Langerhans
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
50. Beta blockers are used for which type of anginal attack
Classic
Nondepolarizing type antagonists
Steady state
Nesiritide (Natrecor)