SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Reason troglitazone was withdrawn from market
Hepatic toxicity
Dexrazoxane
Spironolactone
Physostigmine
2. Inhaled anesthetic that may sensitize the myocardium to arrhythmogenic effects of catecholamines and has produced hepatitis
Betamethasone and dexamethasone
Halothane
Ephedrine
Ethanol - fomepizole
3. Nitrate used to prevent further attacks
Kidney and liver toxicity - diarrhea
Oral and transdermal forms of nitroglycerin
Cocaine 'super - speed'
Citalopram and its metabolite escitalopram
4. Lactam that can be used in PCN allergic patients
Miosis and constipation
Aztreonam
Ethanol or fomepizole
100% O2 and hyperbaric O2
5. Antivirals that are teratogens
Stimulates cGMP which leads to vascular smooth muscle relaxation
Delavirdine - efavirenz - and ribavirin
Succinylcholine
Bupropion
6. Antidepressant associated with seizures and cardiotoxicity
Lupus - like syndrome
Beta blockers
Maprotiline
Niacin
7. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea
Zollinger - Ellison Syndrome
Cevimeline
Arteries and veins
Calcium channel blockers
8. Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Infliximab
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Cholinesterase regenerators - pralidoxime
Megaloblastic anemia
9. Vitamin given with calcium to ensure proper absorption
Abstinence syndrome
Pregnancy
G- CSF (filgrastim) and GM- CSF (sargramostim)
Vitamin D
10. Selective Alpha 1 blocker used for hypertension - BPH - may cause first dose orthostatic hypotension
Aspirin
Epinephrine - dipivefrin
Tissue plasmin activator
Prazosin - terazosin - doxazosin
11. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension
Propofol
Atenolol - acebutolol - and metoprolol
Glucocorticoids
Peripheral neuritis and hepatitis
12. Cholestyramine and colestipol are
Zolpidem - zaleplon
Bile acid - binding resins
Sedation
Sumatriptan - naratriptan - and rizatriptan
13. Treatment of choice for organophosphate overdose
Dexamethasone suppression test
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Atropine
Minoxidil
14. Median toxic dose required for a toxic effect in 50% of the population
Buspirone
Letrozole - anastrozole
TD50
Dry cough - hyperkalemia
15. Nitrate used for acute anginal attacks
Thrombocytopenia
Nitroglycerin sublingual tablets
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Esmolol
16. Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso - enzyme.
Ethosuximide and valproic acid
First order kinetics
Terfenadine and astemizole (have been removed from the market)
Indomethacin
17. Causes bone marrow suppression
Dimercaprol
Hypoglycemia
Methotrexate
Aspirin - Nitrates - CCB - and Beta blockers
18. Peptide causing increased capillary permeability and edema
Bradykinin and histamine
Albuterol
Hepatic
Positive Comb's test - depression
19. Newer NSAID that selectively inhibits COX-2
First generation due to being more lipid - soluble
Ethanol
L- asparaginase
Celecoxib
20. Antiestrogen drugs used for fertility and breast cancer respectively
Clomiphene and tamoxifen
Lispro (Humalog) - aspart - glulisine
Rebound HTN - sedation - dry mouth
Aspirin - metoprolol
21. This agent used to treat dry mouth in Sj
Opioid Analgesics
Cevimeline
Liver enzyme INDUCTION
Temazpam - trizolam - flurazepam
22. '5HT-1d agonist used for migraine headaches '
Gingival hyperplasia - nystagmus - diplopia and ataxia
Increase the DURATION of GABA- mediated chloride ion channels
Sumatriptan - naratriptan - and rizatriptan
Infants - closed angle glaucoma - prostatic hypertrophy
23. Beta 2 agonist toxicity
Demeclocycline
Midodrine
Hydroxychloroquine
Skeletal muscle tremor - tachycardia
24. These agents are used as antidiarrheal
Metronidazole
Diphenoxylate - Loperamide
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Oxidation - reduction - hydrolysis
25. Common SE of spironolactone
Testicular cancer
Ipratropium
Gynecomastia and hyperkalemia
Trazodone
26. Anti - seizure agent that induces formation of liver drug - metabolism enzymes - is teratogen and can cause craniofacial anomalies and spina bifida
Clomipramine
Halothane and methoxyflurane
Oxytocin - ergonovine and ergotamine
Carbamazepine
27. Carbamazepine may cause
Nondepolarizing type antagonists
Agranulocytosis
Halothane and methoxyflurane
Aminocaproic acid
28. Most frequent route of metabolism
Toremifene (Fareston)
Glucuronate - acetic acid - and glutathione sulfate
Dobutamine and dopamine
Hepatic enzymes
29. Most dangerous of the currently popular hallucinogenic drugs - OD leads to nystagmus - marked hypertension - and seizures - presence of both horizontal and vertical nystagmus is pathognomonic
Meperidine
Amantadine
PCP
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
30. Converted to more active form DHT by 5 alpha - reductase
Tricyclic antidepressants (TCA)
Testosterone
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
PGE1
31. 3 zones of adrenal cortex and their products
Nifedipine
PCP
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Depression of medullary and cardiovascular centers
32. May protect against doxorubicin toxicity by scavenging free radicals
Dexrazoxane
Acyclovir; incorporated into viral DNA and chain termination
Low therapeutic index
Mechlorethamine
33. Antidote used for heparin overdose
Dapsone - rifampin and clofazimine combination
Protamine
Methoxyflurane
Streptokinase
34. Interferes with activity of T- lymphocytes
Fentanyl
Excessive hypotension and kidney failure
Calcium
Hydroxychloroquine
35. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Timolol
Disulfiram
Hepatic
Physostigmine
36. Major drug interaction with Quinidine
None
Hydralazine
Increases concentration of Digoxin
Phenoxybenzamine
37. Digoxin toxicity can be precipitated by
Amiodarone
Phenoxybenzamine
Hypokalemia
Yohimbine
38. Benzodiazepines used to promote sleep
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Buspirone
Temazpam - trizolam - flurazepam
39. Anti - seizure drugs used as alternative drugs for mood stabilization
5-7 days
C- peptide
Sotalol
Carbamazepine - gabapentin - lamotrigine - and valproic acid
40. Anti - rheumatic agent also used for Chron's disease
Infliximab
Thrombocytopenic purpura - and CINCHONISM
Finasteride (Proscar and Propecia respectively)
Nateglinide
41. Beta 1 agonists used in acute CHF
Ipratropium
Cholinesterase inhibitors
Steady state
Dobutamine and dopamine
42. CCB are DOC for
43. Agents used in Tourette's dx
Aplastic anemia and renal toxicity
Haloperidol or pimozide
Nitrous oxide
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
44. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure
Cholinesterase regenerators - pralidoxime
Infants
Venlafaxine
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
45. Facilitates GABA presynaptic inhibition
Reducing preload
Diazepam
Maprotiline
Hydroxychloroquine
46. Drug causes teeth discoloration
Dexrazoxane
Epinephrine
Tetracycline
Gynecomastia
47. Drugs available in combination with metformin
Thioridazine
Carvedilol
Glyburide - glipizide - and rosiglitazone
Mast cell stabilizer
48. HMG CoA reductase inhibitors are contraindicated in
SEVERE myelosuppression
Radioactive iodine
Pregnancy
Ascending pathways
49. Benzodiazepine that has efficacy against absence seizures and in anxiety states - such as agoraphobia
Naltrexone
Halothane
Clonazepam
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
50. Muscarinic antagonist used in asthma
Gynecomastia
Dantrolene
Ipratropium
Nifedipine