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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Agents used in treatment of carcinoid tumor
Hydroxychloroquine
Ketanserin cyproheptadine - and phenoxybenzamine
Cisplatin
Noncompetitive antagonist
2. Agent used for anemias associated with renal failure
Cyproterone acetate
Kidney and liver toxicity - diarrhea
Inhibition of protein synthesis at the 50s subunit of ribosome
Erythropoietin
3. Alternative anticoagulant used if HIT develops
hydroxyzine (Atarax)
Adenosine
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Lepirudin
4. DMARDs are slow acting drugs for
Nitrous oxide
Zollinger - Ellison Syndrome
Bupropion
Rheumatic disease
5. Indirect - Acting ACh Agonist - alcohol - short DOA and used in diagnosis of myasthenia gravis
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
Edrophonium
Oxytocin
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
6. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Minocycline
Beta1 agonists
Excessive CNS stimulation (seizures)
Potassium channel blockers
7. Other side effects of Quinidine
Thrombocytopenic purpura - and CINCHONISM
Presynaptic mu - delta - and kappa receptors
Cyclobenzaprine
pregnancy and with K+
8. Diuretic used for mountain sickness and glaucoma
Carbamazepine
Carvedilol
Administration of Vit. B6 (pyridoxine)
Acetazolamide
9. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Bradykinin and histamine
Insulin release from pancreas by modifying K+ channels
Halothane and methoxyflurane
Prostaglandin PGF2a
10. Type of kinetics when a constant percentage of substrate is metabolized per unit time
Propranolol
Timolol
First order kinetics
Tubocurarine
11. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea
Xanthine oxidase
Sulfonamides
Zollinger - Ellison Syndrome
Volume of distribution (VD)
12. Antiestrogen drugs used for fertility and breast cancer respectively
Nicotine
inhibits HMG COA reductase
Clomiphene and tamoxifen
Severe hypertension
13. The selective agents loose their selectivity at
Sodium bicarbonate
high doses
Mivacurium
Letrozole - anastrozole
14. SE of minoxidil
Cocaine and benzocaine
Aplastic anemia and acute hepatic failure
Buspirone
Hypertrichosis
15. Toxicity of anticholinergics
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Norepinephrine and serotonin
Platelet aggregation inhibition
block SLUD (salivation - lacrimation - urination - defecation
16. MOA of aspirin
Estrogen
Irreversibly blocking cyclooxygenase
Dopamine
Streptokinase
17. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis
Acarbose
Gynecomastia hyperkalemia - and impotence
Metronidazole
Bleomycin
18. Anti - rheumatic agent also used for Chron's disease
Risperidone
Calcium channels
Infliximab
Lorazepam - oxazepam - and temazepam
19. This beta blocker is the longest acting
Nadolol
L- dopa
Clonidine - and methyldopa
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
20. Produces both rapid anesthesia and recovery - has antiemetic activity and commonly used for outpatient surgery - may cause marked hypotension
Benzodiazepines and calcium channel blockers
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
Hypokalemia
Propofol
21. PCN active against pseudomonas
Epinephrine
Carbenicillin - piperacillin and ticarcillin
Tubocurarine
Heparin
22. Meglitinide class of drugs
Streptomycin
Repaglinide
Oral and transdermal forms of nitroglycerin
Sulfonamides
23. Weak opioid agonist - poor analgesic - its overdose can cause severe toxicity including respiratory depression - circulatory collapse - pulmonary edema - and seizures
Thiopental
Phentolamine
Propoxyphene
Leuprolide
24. Treatment of motion sickness
Mannitol
Scopolamine - meclizine
Esmolol
ORAL vancomycin
25. Antibiotic causing red - man syndrome - and prevention
Testosterone
Zileuton
Insulin
Vancomycin - infusion at a slow rate and antihistamines
26. Antidote used for organophosphate/anticholinesterase poisoning
Atropine - pralidoxime (2- PAM)
Fludrocortisone and deoxycorticosterone
Folic acid
prolongs QT and PR interval
27. Agents acting in the CNS or in the skeletal muscle - used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease
Spasmolytic drugs
Cytomel
Halothane and methoxyflurane
Cevimeline
28. Produce mydriasis and cycloplegia
Atropine - homatropine - C1208 tropicamide
Ketanserin cyproheptadine - and phenoxybenzamine
Alkalinize urine - dialysis
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
29. Drug is used with testosterone for male fertility
Leuprolide
Bleeding
inhibit phospholipase A2
Tubocurarine
30. Class of drugs whose MOA utilizes ligand gated ion channels
Benzodiazepines and calcium channel blockers
Alprazolam and Clonazepam
Dry cough
Pregnancy
31. Agent with long duration of action and is most likely to cause histamine release
Finasteride (Proscar and Propecia respectively)
Ultralente (humulin U)
Adalimumab - infliximab and etanercept
Tubocurarine
32. Bleomycin+vinblastine+etoposide+cisplatin produce almost a 100% response when all agents are used for this neoplasm
Low - potency typical antipsychotics and clozapine
Testicular cancer
Bone marrow and teeth discoloration for children under 8 years of age
Kidney and liver toxicity - diarrhea
33. Orthostatic hypotension and QT prolongation
Normal C- peptide
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Low potency phenothiazines and ziprasidone
Glyburide - glipizide - glimepiride - etc.
34. MOA of AGI's
Clopidogrel and ticlopidine
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
Seizures
Prolongs QT interval
35. DOC for CMV retinitis
Ganciclovir
Temazpam - trizolam - flurazepam
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Epinephrine
36. This agent regenerates active cholinesterase and is a chemical antagonist used to treat organophosphate exposure
Platelet aggregation inhibition
Insulin glargine
high doses
Pralidoxime
37. Aminoglycosides used with loop diuretics potentiate adverse effect
Ototoxicity
Nitrous oxide
Octreotide
Cephalosporins
38. Clinical uses of these agents include treatment of HTN - angina - arrhythmias - chronic CHF - and selected post MI patients
Beta blockers
Aminoglutethimide
Ketoralac
Amphetamines
39. Antihistamine that can be used for anxiety and insomnia and is not addictive
Aplastic anemia and acute hepatic failure
hydroxyzine (Atarax)
G- CSF (filgrastim) and GM- CSF (sargramostim)
Nitrous oxide
40. Difference between aspirin and other NSAIDS
Potency
Ethanol - Barbiturates - and Benzodiazepines
Nonselective Muscarinic Antagonists
Aspirin irreversibly inhibits cyclooxygenase
41. Difference between COX 1 and COX 2
Morphine
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Edrophonium
Insulin secretagogue - closes ATP- sensitive K+ channel
42. These LA's have surface activity
Fluorocarbons and Industrial solvents
Cocaine and benzocaine
Dapsone - rifampin and clofazimine combination
Hyperkalemia
43. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure
Paclitaxel (taxol)
Nefazodone
Sulfonamides
Corticosteroids
44. Mediator of tissue pain - edema - inactivated by ACE - and may be a contributing factor to the development of angioedema
Bradykinin
Testicular cancer
Testosterone
Ezetimibe (Zetia)
45. Agent for pernicious anemia
Methoxyflurane
Cyanocobalamin (Vit B12)
Phenoxybenzamine
Betamethasone and dexamethasone
46. Activation of these receptors open K+ ion channels to cause membrane hyperpolarization
Postsynaptic Mu receptors
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Cortisone and hydrocortisone (equivalent to cortisol)
Low potency phenothiazines and ziprasidone
47. Anti - estrogen used for estrogen receptor + breast cancer
Tamoxifen
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Leuprolide
Sinus tachycardia and serious arrhythmias
48. MOA of thrombolytics
Degradation of fibrin clots and are administered IV
Bradykinin and histamine
Vasodilation
Nesiritide (BNP)
49. Radio contrast media that inhibits the conversion of T4 to T3
Ipodate
Valproic acid - carbamazepine - phenytoin and gabapentin
Nifurtimox
Acid reflux disease - duodenal ulcer and peptic ulcer disease
50. Can be effective for short term therapy of thyroid storm - but after several weeks of therapy causes an exacerbation of hyperthyroidism
Lithium toxicity
Acute intermittent porphyria
Iodide salts
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)