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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Plasma concentration of a drug at a given time






2. Epinephrine is often mixed with a local anesthetic to






3. MOA action of cromolyn






4. One depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis - causes muscle pain postoperatively and myoglobinuria may occur






5. '5HT-1d agonist used for migraine headaches '






6. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma






7. Used for hairy cell leukemia; it stimulates NK cells






8. Drug of choice for leprosy






9. Antidepressants with no effect on BP - no sedation






10. Carbonic anhydrase inhibitor






11. Beta 1 agonists used in acute CHF






12. Treatment with cancer chemotherapy at high doses every 3-4 weeks - too toxic to be used continuously






13. Long acting sympathomimetic - sometimes used to improve urinary continence in children and elderly with enuresis






14. Presynaptic Alpha 2 agonist used in HTN - and acts centrally






15. Another pneumonic for anticholinergic toxicity

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16. Selective Alpha 1 blocker used for hypertension - BPH - may cause first dose orthostatic hypotension






17. Reduce transient hyper GI motility






18. Tolerance to all effects of opioid agonists can develop except






19. Except for these agents all SSRI have significant inhibition of CytP450 enzymes






20. Technique used to diagnose perianal itching - and the drug used to treat it






21. Thiazolidinediones






22. This may antagonize activity of local anesthetics






23. Potassium sparing diuretics inhibit






24. Rapid acting insulins that do not self - aggregate






25. Fibrates are contraindicated in






26. Benzodiazepine that is used for anesthesia






27. Antidote used for acetaminophen (APAP) toxicity






28. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias






29. Weak opioid agonist - poor analgesic - its overdose can cause severe toxicity including respiratory depression - circulatory collapse - pulmonary edema - and seizures






30. Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage - cardiac arrhythmias - and myocardial infarction






31. SE of imipenem






32. Diuretic used for mountain sickness and glaucoma






33. Newer estrogen receptor antagonist used in advanced breast cancer






34. This is the drug of choice for anaphylactic shock






35. SE of long term (>5 days) corticosteroid therapy and remedy






36. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma






37. Endogenous insulin contains






38. Reason fluoroquinolones are contraindicated in children and pregnancy






39. Antidepressant with MOA as alpha 2 antagonist - has effects on both 5- HT and NE - blocks histamine receptors - and is sedating






40. MOA of erythromycin






41. MOA of neuroleptics






42. Non ergot agents used as first - line therapy in the initial management of Parkinson's






43. Common side effect of hypnotic agents






44. Antidote used for heparin overdose






45. Initial DMARD of choice for patients with RA






46. Cephalosporins able to cross the BBB






47. MOA of sulfonamides






48. Reduced seizure threshold






49. Mast cells to reduce release of hisamine and inflammatory mediators






50. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia







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