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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Class of drugs that may cause cross - sensitivity with thiazide diuretics
Cyproterone acetate
Echothiophate
Sulfonamides
Peripheral neuritis and hepatitis
2. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Valproic acid
Dimercaprol
Cevimeline
Vancomycin - infusion at a slow rate and antihistamines
3. One depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis - causes muscle pain postoperatively and myoglobinuria may occur
Hepatic
sulfamethoxazole/ trimethoprim
Insulin secretagogue - closes ATP- sensitive K+ channel
Succinylcholine
4. Anti - seizure drugs used also for pain of neuropathic orgin
Spironolactone
Dimercaprol - EDTA
Bradykinin
Gabapentin
5. These agents are CNS depressants
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
Ethanol - Barbiturates - and Benzodiazepines
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Pentoxifylline
6. IV barbiturate used as a pre - op anesthetic
Thiopental
Carmustine (BCNU) and lomustine (CCNU)
Cholinesterase inhibitors
Propoxyphene
7. Tolerance to all effects of opioid agonists can develop except
Miosis and constipation
Primaquine
B- blockers
L- asparaginase
8. H2 blocker that causes the most interactions with other drugs
Vitamin D
Cimetidine
block SLUD (salivation - lacrimation - urination - defecation
Steady state
9. Anticoagulant of choice in pregnancy
Nephrotoxicity
Heparin
Hypercalcemia
Estrogen (HRT- Hormone replacement therapy)
10. Example of three antidepressants that are indicated for obsessive compulsive disorder
Clomipramine - fluoxetine and fluvoxamine
Buspirone
Pralidoxime
Lithium toxicity
11. Drugs available in combination with metformin
Aspirin - Nitrates - CCB - and Beta blockers
Salmeterol
Dexamethasone suppression test
Glyburide - glipizide - and rosiglitazone
12. SE for Felbamate
First pass effect
ACE inhibitors
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Aplastic anemia and acute hepatic failure
13. Antidote used in poisonings: copper (Wilson's disease) - lead - mercury - and arsenic
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Penicillamine
Muscarinic blockers
Cocaine 'super - speed'
14. Drug used supraventricular arrhythmias
Acetazolamide
Digoxin
Tubocurarine
Seizures
15. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea
Zollinger - Ellison Syndrome
Alkalinize urine - dialysis
Tolerance
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
16. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation
Fluorocarbons and Industrial solvents
Theophylline
Methimazole and propylthiouracil (PTU)
Citalopram and its metabolite escitalopram
17. Rate limiting step of alcohol metabolism
Hypertrichosis
Carmustine (BCNU) and lomustine (CCNU)
Aldehyde dehydrogenase
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
18. A hormone whose mechanism of action (MOA) utilizes intracellular receptors
Neutropenia and agranulocytosis
Cefixime (3rd) generation
Torsades de pointes
Thyroid and steroid hormones
19. Alpha 1 agonist toxicity
Valproic acid
Hypertension
Fluoxetine
Morphine
20. Removal of PCP may be aided
Urinary acidification and activated charcoal or continual nasogastric suction
Steroids
Aspirin - metoprolol
Cholinesterase regenerators - pralidoxime
21. SE of Aspirin
GI bleeding
Retinal destruction and dermatitis
Older antipsychotic agents - D2 receptors
sodium polystyrene sulfonate (Kayexalate)
22. Agent effective in physiologic and essential tremor
Rhabdomyolysis
Hydroxychloroquine
NSAIDS
Propranolol
23. Organophosphate anthelmintic agent with long DOA
Zileuton
Corticosteroids
Topical mupirocin (Bactroban)
Metrifonate
24. Another pneumonic for anticholinergic toxicity
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25. The most common type of drug interaction of sedative hypnotics with other depressant medications
Nesiritide (BNP)
Additive CNS depression
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
26. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis
Liver toxicity - increased serum cholesterol
Pralidoxime - atropine
Acetazolamide
Flumazenil
27. Opioids used in anesthesia
Mirtazapine
nephro and ototoxicity
Alkylating agent
Morphine and fentanyl
28. Most inhaled anesthetics SE
Iodide salts
Decrease arterial blood pressure
Acyclovir; incorporated into viral DNA and chain termination
EOS
29. Important in synthesis of glucose to glycogen in the liver
Naloxone
GLUT 2
Low therapeutic index
Oxidation - reduction - hydrolysis
30. Toxicity of amphotericin
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
sodium polystyrene sulfonate (Kayexalate)
Nephrotoxicity
Beta1 agonists
31. Antidote for acetaminophen toxicity
Rheumatic disease
Betamethasone and dexamethasone
N- acetylcysteine
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
32. NSAID also available as an ophthalmic preparation
Diethylstilbestrol (DES)
Chloramphenicol
Clozapine
Diclofenac - ketoralac
33. Mediator of tissue pain - edema - inactivated by ACE - and may be a contributing factor to the development of angioedema
Aminocaproic acid
G- CSF (filgrastim) and GM- CSF (sargramostim)
Older antipsychotic agents - D2 receptors
Bradykinin
34. Drugs of choice for status epilepticus
Methoxyflurane
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Tamsulosin
Amoxicillin
35. Partial opioid agonist - considered a strong analgesic - has a long duration of action and is resistant to naloxone reversal
Buprenorphine
Acarbose - miglitol
First pass effect
Hyperuricemia - hypokalemia and ototoxicity
36. Major SE of bisphosphonates
Buprenorphine
Chemical esophagitis
Noncompetitive antagonist
Odansetron - granisetron
37. MOA for Ethosuximide
Full agonist
Calcium channels
GLUT 2
Zafirlukast and montelukast
38. System that increases in activity with chronic ethanol exposure and may contribute to tolerance
Hepatic enzymes
Betamethasone and dexamethasone
Yohimbine
EOS
39. Drug that causes contraction of the uterus
Oxytocin
Diphenhydramine and cimetridine - respectively
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
PTU
40. Heterocyclic antidepressants least likely to affect sexual performance - used for management of nicotine withdrawal - SE's include dizziness - dry mouth - aggravation of psychosis - and seizures
Drug induced Parkinsonism
Bupropion
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Reduce the loss from area of injection
41. MAOI should not be administered with SSRI's or potent TCA's due to development of this condition
Fentanyl
Repaglinide
Serotonin syndrome
Aldehyde dehydrogenase
42. Antidote for salicylate intoxication
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Mirtazapine
Alkalinize urine - dialysis
IV and IM (only LMW)
43. Class III antiarrhythmic that exhibits properties of all 4 classes
IV and IM (only LMW)
Amiodarone
Neutro - leuko and thrombocytopenia
Serum ammonia and LFT's
44. Alpha 1selective blockers
Bleomycin
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Cimetidine
Rhabdomyolysis
45. Approved for use in severe pulmonary HTN
Zolpidem
Penicillamine
G- CSF (filgrastim) and GM- CSF (sargramostim)
PGI2 (epoprostenol)
46. Difference between COX 1 and COX 2
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Prinzmetal's angina
nephro and ototoxicity
Cyclophosphamide
47. Agent that is a partial agonist for the 5- HT1A receptor
First pass effect
Buspirone
Parathion
6- mercaptopurine (6- MP)
48. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
Echothiophate
Chlorpheniramine or cyclizine
Amitriptyline
Fluoxetine
49. DOC for status epilepticus
Fluorocarbons and Industrial solvents
Epinephrine
Diazepam
Finasteride (Proscar and Propecia respectively)
50. Nonselective alpha - blocking drug - long acting and irreversible - and used to treat pheochromocytoma. Blocks 5- HT - so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis
Clomipramine
Alprazolam and Clonazepam
Phenoxybenzamine
Excessive hypotension and kidney failure