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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Occurs when sedative hypnotics are used chronically or at high doses
Xanthine oxidase
Dextroamphetamines and methamphetamine
Low - potency typical antipsychotics and clozapine
Tolerance
2. SE of acetaminophen
Nandrolone - oxymetholone - and oxandrolone
Hepatotoxicity
Cyproterone acetate
Digibind
3. Antidote used for benzodiazepine toxicity
Methotrexate
Dexamethasone suppression test
Flumazenil
Infants - closed angle glaucoma - prostatic hypertrophy
4. Topical DOC in impetigo
Topical mupirocin (Bactroban)
Diclofenac - ketoralac
Beta - blockers such as propranolol
Calcium
5. Cystitis - postoperative bladder spasms - or incontinence
Naloxone
Zileuton
Elderly patients
Oxybutynin - dicyclomine
6. Agent used in CHF that is a selective alpha and nonselective beta blocker
Glucuronate - acetic acid - and glutathione sulfate
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Caffeine
Carvedilol
7. 'Date rape drug'
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Flunitrazepam (rohypnol)
Cyproheptadine
Thiopental
8. Initial DMARD of choice for patients with RA
Ticlopidine
Methotrexate
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Levodopa
9. Leads to respiratory depression progressing to coma and death
Glyburide - glipizide - and rosiglitazone
Potential for development of Reye's syndrome
Overdose of opioids
Midazolam
10. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression
Sulfonamides
Insulin glargine
Carboplatin
Vasodilation
11. Different steps of Phase I
Sulfonamides
Valproic acid
Buspirone
Oxidation - reduction - hydrolysis
12. MOA of thiazide diuretics
sodium polystyrene sulfonate (Kayexalate)
L- thyroxine (T4)
Tricyclic antidepressants (TCA)
Inhibit Na+/Cl - cotransport
13. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure
Carmustine (BCNU) and lomustine (CCNU)
Disulfiram - like reaction
Nefazodone
Glyburide - glipizide - glimepiride - etc.
14. Toxic to the liver - kidney - lungs - bone marrow - peripheral nerves - and cause brain damage in animals - sudden death has occurred following inhalation
Celecoxib
Fluorocarbons and Industrial solvents
Acarbose
Temazpam - trizolam - flurazepam
15. Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Risperidone
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Bradykinin
Digoxin
16. Longer acting Beta 2 agonist is recommended for prophylaxis of asthma
Nondepolarizing type antagonists
Deferoxamine
Hyperkalemia
Salmeterol
17. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
Propranolol
Morphine - methadone - meperidine - and fentanyl
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
L- dopa
18. Ability of a drug to produce 100% of the maximum response regardless of the potency
Indomethacin
Inhibits osteoclast bone resorption
Full agonist
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
19. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Valproic acid - carbamazepine - phenytoin and gabapentin
Miosis and constipation
Estrogen (HRT- Hormone replacement therapy)
Levodopa
20. Lactam that can be used in PCN allergic patients
inhibits Na+/K+/2Cl - cotransport
Fentanyl
Aztreonam
Chlordiazepoxide and Diazepam
21. Anti - viral agents associated with Stephen Johnson syndrome
Nevirapine - amprenavir
Long acting cholinesterase inhibitors
Scopolamine - meclizine
Potassium channel blockers
22. Vancomycin MOA
Dantrolene
Gynecomastia
Blocks peptidoglycan synthesis
Islets of Langerhans
23. Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)
Pramipexole and ropinirole
Venlafaxine
Methicillin - nafcillin - and dicloxacillin
Muscarinic blockers
24. Amino acid derivative - active as an insulin secretagogue
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
Thioridazine
Neuroleptanesthesia
Nateglinide
25. Beta 2 agonist used to suppress premature labor - but cardiac stimulatory effects may be hazardous to mother and fetus
Bradykinin and histamine
Terbutaline
Aplastic anemia and renal toxicity
Thrombocytopenic purpura - and CINCHONISM
26. SE of nesiritide
Skeletal muscle tremor - tachycardia
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Excessive hypotension and kidney failure
Acarbose - miglitol
27. CCB contraindicated in CHF
Chloramphenicol
Risperidone
Pre - existing cardiac or renal disease
Verapamil
28. SE of long term (>5 days) corticosteroid therapy and remedy
Hepatic enzymes
Midodrine
Thiopental
Adrenal suppression and weaning slowly - respectively
29. Drugs of choice for absence seizures
Sodium bicarbonate
Gynecomastia
Ethosuximide and valproic acid
Neostigmine
30. Drug of choice for myoclonic seizures
Aldehyde dehydrogenase
Valproic acid
Procarbazine
Protamine sulfate
31. Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons
Methotrexate
Ascending pathways
Benztropine
Pralidoxime - atropine
32. DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics
Lorazepam - oxazepam - and temazepam
Dantrolene
Nitroglycerin sublingual tablets
Mivacurium
33. MOA of lovastatin (STATIN)
inhibits HMG COA reductase
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
Desmopressin (DDAVP)
Lispro (Humalog) - aspart - glulisine
34. Amphetamine agents
Cocaine
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Dextroamphetamines and methamphetamine
Carvedilol
35. Common SE of sulfonylureas - repaglinide - and nateglinide
Hypoglycemia
Disulfiram - like reaction
Chemical esophagitis
Bromocriptine
36. Prototypical drug is atropine
Bradykinin
Dextroamphetamines and methamphetamine
Clozapine
Nonselective Muscarinic Antagonists
37. Antidote used in poisonings: copper (Wilson's disease) - lead - mercury - and arsenic
REM is decreased
Penicillamine
Neuromuscular blocking drugs
First order kinetics
38. Major SE of bisphosphonates
Demeclocycline
Cocaine 'super - speed'
Mifepristone (RU-486)
Chemical esophagitis
39. Vascular effects of metformin
Decreased micro and macro vascular disease
Neutropenia and agranulocytosis
Mast cell stabilizer
GFR
40. Antiarrhythmic that exhibits Class II and III properties
Metformin
Lithium
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Sotalol
41. Antidote for acetaminophen toxicity
Acarbose
Fluorocarbons and Industrial solvents
N- acetylcysteine
Haloperidol
42. Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine - like side effects
Pilocarpine - carbachol - physostigmine
Benztropine
Low therapeutic index
5-7 days
43. Chronic orthostatic hypotension can be treated with
Midodrine
Cartilage damage
Sedation
B- blockers
44. MOA of nesiritide
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Sulfasalazine
Increasing sodium excretion and decreases arterial and venous tone
Somatostatin
45. Ergot alkaloid that is a partial agonist at D2 receptors in the brain - used for patients who are refractory or cannot tolerate levodopa - causes erythromelalgia
Bromocriptine
Timolol
Calcitonin (salmon prep)
Digoxin
46. For rebound HTN from rapid clonidine withdrawal
Phentolamine
Ethanol - fomepizole
Pulmonary embolism and DVT
high doses
47. Class of anti - arrhythmics that has a pro - arrhythmic effect (CAST trial) - therefore are used as last line agents
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
ORAL vancomycin
Class IC (flecainide - propafenone - moricizine)
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
48. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)
Vincristine
Fentanyl
Entacapone and Tolcapone
Fluoxetine
49. Selectivity of a drug for its receptor
Imipramine
Specificity
Clozapine
Kidney and liver toxicity - diarrhea
50. These prevent the action of Ach at the skeletal muscle endplate to produce a 'surmountable blockade -' effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)
Barbiturates - phenytoin - carbamazepine - and rifampin
Parathion
Nondepolarizing type antagonists
Amitriptyline