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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Some cell cycle non - specific drugs
Nandrolone - oxymetholone - and oxandrolone
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Mechlorethamine
nephro and ototoxicity
2. This route is associated with rapid tolerance and psychologic dependence
Phenytoin
Hepatotoxicity
IV administration
Affect calcium - potassium - and sodium channels
3. SE of nitrates
Phentolamine
LSD
Clopidogrel and ticlopidine
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
4. DOC for RSV
Tubocurarine
Ribavirin
Alprazolam
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
5. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion
Side - effect profile and prior pt response
Cephalosporins
Abciximab - tirofiban and eptifibatide
Neostigmine
6. SE of ACE inhibitors
Dry cough - hyperkalemia
Nondepolarizing Neuromuscular Blockers
Mifepristone
Rhabdomyolysis
7. Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine - diphenhydramine or muscarinic blocker
Pindolol and acebutolol
Haloperidol
Hydroxychloroquine
Dexrazoxane
8. Diuretic used for mountain sickness and glaucoma
Aldehyde dehydrogenase
Acetazolamide
Increasing sodium excretion and decreases arterial and venous tone
Penicillamine
9. Condition will result from in combination of MAOI with tyramine containing foods (ex. wine - cheese - and pickled meats)
Cholinesterase inhibitors
Digibind
Hypertensive crisis
Didanosine
10. Atropine fever is the most dangerous effect and can be lethal in this population group
SSRIs
Clozapine
Gynecomastia
Infants
11. Converted to more active form DHT by 5 alpha - reductase
Testosterone
Indomethacin
Dipyridamole
Dexrazoxane
12. The most common type of drug interaction of sedative hypnotics with other depressant medications
Nitrites
Beta1 agonists
Additive CNS depression
Aspirin irreversibly inhibits cyclooxygenase
13. SE of colchicine
Lepirudin
Kidney and liver toxicity - diarrhea
Ethanol or fomepizole
Sulfonamides
14. Antidote for beta - blockers and hypoglycemia
Glucagon
Heroin - morphine - oxycodone - meperidine and fentanyl
Prinzmetal's angina
L- dopa
15. MOA for benzodiazepines and barbiturates
Class IC (flecainide - propafenone - moricizine)
GABA- related targets
Thick ascending limb
Doxepin
16. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation
increase the FREQUENCY of GABA- mediated chloride ion channel opening
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Olanzapine - aripiprazole - and sertindole
Increasing afterload and tissue perfusion declines
17. Selective alpha agonists that decreases aqueous secretion
Deferoxamine
Protease inhibitors
Apraclonidine - brimonidine
Oxytocin - ergonovine and ergotamine
18. Population group especially sensitive to side effects of antidepressants
Sedation
B- blockers
Diphendydramine
Elderly patients
19. SE of acetaminophen
Aldehyde dehydrogenase
Dimenhydrinate - meclizine - and other 1st generation
Fluoxetine (Sarafem)
Hepatotoxicity
20. Irreversible - nonselective COX inhibitor
Alkalinize urine - dialysis
Disulfiram - like reaction
Aspirin
Hepatotoxicity
21. Approved for use in severe pulmonary HTN
Nitroglycerin sublingual tablets
PGI2 (epoprostenol)
Nefazodone
Red urine discoloration
22. DOC for paroxysmal supraventricular tachycardia; has high efficacy and short duration of action
Nephro and ototoxicity
Adenosine
Mifepristone (RU-486)
Esmolol
23. Direct vasodilator of arteriolar smooth muscle
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Hydralazine
Mast cell stabilizer
Baclofen
24. This parenteral beta blocker is a short acting (minutes)
Esmolol
Calcium channel blockers
Terbutaline
Carmustine (BCNU) and lomustine (CCNU)
25. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression
Cholinesterase inhibitors
Carboplatin
Metformin
Constipation - edema - and headache
26. Ability of a drug to produce 100% of the maximum response regardless of the potency
Erythromycin
Stimulates cGMP which leads to vascular smooth muscle relaxation
Full agonist
Atrial fibrillation and CHF
27. Type of kinetics when a constant percentage of substrate is metabolized per unit time
Ipodate
Heparin induced thrombocytopenia (HIT)
Inhibit Cytochrome P450 3A4
First order kinetics
28. Pneumonic for 3 zones of adrenal cortex
C- peptide
GFR
Irreversibly blocking cyclooxygenase
Haloperidol
29. Non - benzodiazepine used for sleep
Cartilage damage
Protease inhibitors
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Zolpidem
30. Drugs of choice for absence seizures
Ethosuximide and valproic acid
Older antipsychotics
Nitroprusside
Ethanol
31. NSAID also available as an ophthalmic preparation
Vitamin K and Fresh frozen plasma (FFP)
Prinzmetal's angina
Rheumatic disease
Diclofenac - ketoralac
32. GHRH analog used as diagnostic agent
Pentoxifylline
Ceftriaxone
Bromocriptine
Sermorelin
33. Barbiturates MOA
Atropine
Increase the DURATION of GABA- mediated chloride ion channels
Leuprolide
Vasodilation
34. Anti - seizure drugs used as alternative drugs for mood stabilization
Inhibits osteoclast bone resorption
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Abciximab - tirofiban and eptifibatide
Glargine (Lantus) - detemir
35. Tolerance to all effects of opioid agonists can develop except
Lithium toxicity
high doses
Rhabdomyolysis
Miosis and constipation
36. THC is active ingredient - SE's include impairment of judgment - and reflexes - decreases in blood pressure and psychomotor performance occur
Norepinephrine and serotonin
Interferon alpha
Competitive antagonist
Marijuana
37. Antidote used for opioid toxicity
Sulfonamides
Carmustine (BCNU) and lomustine (CCNU)
Naloxone (IV) - naltrexone (PO)
Drug induced Parkinsonism
38. Allopurinol treats chronic gout by decreasing uric acid production by inhibiting
Xanthine oxidase
Verapamil
Epinephrine - dipivefrin
NSAIDS
39. Scabicide organophosphate
Malathion
Thioamides - iodides - radioactive iodine - and ipodate
Zero order kinetics
Phentolamine
40. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Amphetamines
Methoxyflurane
Potency
Glucocorticoids
41. Longer acting Beta 2 agonist is recommended for prophylaxis of asthma
Paclitaxel (taxol)
Low therapeutic index
Salmeterol
Cholinesterase inhibitors
42. IV Drug used Hypertensive Crisis
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Interleukin 11 (oprelvekin)
Pregnancy
Nitroprusside
43. SE of HMG COA reductase inhibitors
Nitroprusside
Sulfonamides
Rhabdomyolysis and Hepatotoxicity
Estrogen (HRT- Hormone replacement therapy)
44. Alkylating agent - vesicant that causes tissue damage with extravasation
GFR
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Iodide salts
Mechlorethamine
45. NSAID used in gout
Nifedipine
Indomethacin
Nausea
Protamine sulfate
46. CCB with predominate effect on arteriole dilation
Ototoxicity
Thyroid and steroid hormones
Nifedipine
NSAIDS
47. What do alpha cells in the pancreas produce?
Levodopa
Glucagon
Chlordiazepoxide and Diazepam
Prazosin - terazosin - doxazosin
48. Used for SIADH
Abstinence syndrome
Demeclocycline
Neostigmine
Stevens - Johnson syndrome
49. Side effects occuring in antipsychotics that block dopamine
GFR
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Lipoprotein lipase
50. Agent used for anemias associated with renal failure
Organic nitrites
Bromocriptine
Glucagon
Erythropoietin