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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. SE of Aspirin
GI bleeding
Didanosine
Adenosine
Additive CNS depression
2. Blows DNA (breaks DNA strands) - limiting SE is pulmonary fibrosis
Thrombocytopenia
Bleomycin
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Penicillamine
3. Antidepressants with no effect on BP - no sedation
inhibits HMG COA reductase
SSRIs
Disulfiram
Dantrolene
4. NSAID also available as an ophthalmic preparation
Metronidazole
Diclofenac - ketoralac
Acetazolamide
C- peptide
5. Agent used in the treatment of alcoholism - if alcohol is consumed concurrently - acetaldehyde builds up and results in nausea - headache - flushing - and hypotension
Adalimumab - infliximab and etanercept
Nandrolone - oxymetholone - and oxandrolone
Disulfiram
Lithium
6. Antidote for thrombolytics
Aminocaproic acid
Hypertrichosis
SSRI's - bupropion - and venlafaxine
Antithrombin 3
7. Specific pharmacokinetic characteristic of amiodarone
Log - kill hypothesis
Cholinesterase inhibitors
Prolonged half - life - up to six weeks
Urinary acidification and activated charcoal or continual nasogastric suction
8. Anti - psychotic not shown to cause tardive dyskinesia
Lactic acidosis
Oral and transdermal forms of nitroglycerin
Clozapine
Retinal destruction and dermatitis
9. Anti - seizure drugs used as alternative drugs for mood stabilization
Nortriptyline - Desipramine
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Etidronate
Cyproheptadine
10. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
Aztreonam
Amrinone and milrinone
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
Nitroprusside
11. All antidepressants have roughly the same efficacy in treating depression - agents are chosen based on these criterion
Echothiophate
Nevirapine - amprenavir
Hepatic enzymes
Side - effect profile and prior pt response
12. This beta blocker is the longest acting
Nadolol
Classic
Diphenoxylate - Loperamide
Cardiac anomalies and is contraindicated in pregnancy or lactation
13. Orthostatic hypotension and QT prolongation
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Valproic acid
Low potency phenothiazines and ziprasidone
Olanzapine
14. Antidote for beta - blockers and hypoglycemia
Phase I
Glucagon
Potassium channel blockers
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
15. Toxicity caused by nitroprusside and treatment
Cyanide toxicity treated with sodium thiosulfate
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Phase I
Epinephrine - dipivefrin
16. Drug is used with testosterone for male fertility
Reducing progression of heart failure (never use in acute heart failure)
Flutamide (Eulexin)
Leuprolide
Testicular cancer
17. Exogenous insulin contains
Little C- peptide
Cerebral hemorrhage
Ortho - Evra
Quetiapine
18. Common SE of spironolactone
Interleukin 11 (oprelvekin)
Gynecomastia and hyperkalemia
Peripheral neuritis and hepatitis
Platelet aggregation inhibition
19. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Chlorpropamide
Pregnancy
Stevens - Johnson syndrome
Thioridazine
20. Fluoride released by metabolism of this inhaled anesthetic may cause renal insufficiency
Streptokinase
Islets of Langerhans
Carboplatin
Methoxyflurane
21. Drug increases the renal clearance hence decreases levels of lithium
GLUT 4
Theophylline
Arteries and veins
Pilocarpine - carbachol - physostigmine
22. MOA of NSAIDS
inhibit prostaglandin synthesis by inhibiting cyclo - oxygenase (cox)
Cutaneous flush
Ultralente (humulin U)
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
23. Side effects seen with tricyclic antidepressants
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Overdose of opioids
Valproic acid
high doses
24. SE of loop (furosemide) diuretics
Hyperuricemia - hypokalemia and ototoxicity
Carbenicillin - piperacillin and ticarcillin
Beta blockers
Hepatotoxicity
25. MOA of nitrates
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Oxybutynin - dicyclomine
Adenosine
First pass effect
26. Prostaglandins that cause abortions
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
ORAL vancomycin
Inhibits osteoclast bone resorption
27. What do delta cells in the pancreas produce?
block SLUD (salivation - lacrimation - urination - defecation
Somatostatin
Physostigmine
Venlafaxine
28. Facilitates GABA presynaptic inhibition
Gastric ulcers and GI Bleeding
Thyroid and steroid hormones
Amphetamines
Diazepam
29. Three C's associated with TCA toxicity
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Baclofen
NO - chloroform - and diethyl ether
Prednisone - methylprednisolone - prednisolone - and triamcinolone
30. Benzodiazepines used to promote sleep
Temazpam - trizolam - flurazepam
Zafirlukast and montelukast
Reduce inhibition - suppress anxiety - and produce relaxation
Succinylcholine
31. Heparin (PTT) increases activity of
Desmopressin (DDAVP)
Fluoxetine
Antithrombin 3
Liver toxicity - increased serum cholesterol
32. Reversal of blockade by neuromuscular blockers
LSD
Infants
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Cholinesterase inhibitors
33. Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin
Sodium channel blockers
Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
Infants
Diazepam
34. Antipsychotic having the strongest autonomic effects
Reduce aqueous secretion
Thioridazine
Phenoxybenzamine
Risperidone
35. Prototypical drug is atropine
Nonselective Muscarinic Antagonists
Thyroxine
Cosyntropin
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
36. DOC for Legionnaires' disease
CNS depressants
Erythromycin
Insulin
Lithium
37. Anti - microbials that cause hemolysis in G6PD- deficient patients
Gynecomastia hyperkalemia - and impotence
Sulfonamides
Adenosine
Benzodiazepines and calcium channel blockers
38. Technique used to diagnose perianal itching - and the drug used to treat it
Inhibits osteoclast bone resorption
Zolpidem - zaleplon
Midazolam
Scotch tape technique and mebendazole
39. MOA of both generations
Insulin release from pancreas by modifying K+ channels
Competitive antagonist
Terfenadine and astemizole (have been removed from the market)
Alkalinize urine - dialysis
40. Class of drugs that may cause cross - sensitivity with thiazide diuretics
Spasmolytic drugs
Sulfonamides
Cocaine
Methotrexate
41. Newer atypical antipsychotic used for bipolar disorder - known to cause weight gain - and adversely affect diabetes
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
Olanzapine
Timolol
Beta - blockers such as propranolol
42. Drugs of choice for status epilepticus
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Morphine
Half - life (T1/2)
Carvedilol
43. Amount of drug necessary to elicit a biologic effect; refers to the drug's strength
Beta1 agonists
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
lispro insulin - aspart insulin - glulisine insulin
Potency
44. DOC for giardia - bacterial vaginosis - pseudomembranous colitis - and trichomonas
Selective inhibitor of microtubule assembly
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Metronidazole
45. Antiarrhythmic effective in most types of arrhythmia
Prinzmetal's angina
Amiodarone
Octreotide
Organic nitrites
46. Anti - malarial drug used in rheumatoid arthritis (RA)
Oxytocin
Hydroxychloroquine
Tinnitus - GI bleeding
Bleomycin
47. Antidepressant associated with seizures and cardiotoxicity
Maprotiline
Glucagon
Calcium
Dexrazoxane
48. Drug of choice for myoclonic seizures
Midazolam
Valproic acid
Ondansetron - granisetron - dolasetron and alosetron
Cytomel
49. A1a - selective blocker with no effects on HTN used for BPH
Tamsulosin (Flomax)
Bradykinin and histamine
Caffeine
Vitamin K and Fresh frozen plasma (FFP)
50. Concurrent use of fibrates and statins increases risk of
PGE1
Rhabdomyolysis
Gynecomastia and hyperkalemia
inhibit phospholipase A2