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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Increase bone density - also being tested for breast CA prophylaxis
Nateglinide
Spironolactone
Vitamin B12
Raloxifene (SERM- selective estrogen receptor modulator)
2. Osmotic diuretic used to treat increased intracranial pressure
Mannitol
Risperidone
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Naloxone
3. Antidote used for methanol and ethylene glycol
Long acting cholinesterase inhibitors
SEVERE myelosuppression
Ethanol or fomepizole
Cp
4. Inhalant anesthetics
NO - chloroform - and diethyl ether
Atropine - homatropine - C1208 tropicamide
Ototoxicity
Spasmolytic drugs
5. Similar to clonidine and may cause hypotension
Heparin
Tizanidine
Selegiline
Protamine sulfate
6. MOA of penicillin
Neutropenia and agranulocytosis
ACE inhibitors
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Inhibits osteoclast bone resorption
7. Tolerance to all effects of opioid agonists can develop except
Kidneys
Miosis and constipation
Aspirin
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
8. Used intravenously for acute arrhythmias during surgery
Tamsulosin
Bleeding
Esmolol
Ascending pathways
9. Used for hairy cell leukemia; it stimulates NK cells
Interferon alpha
Insulin
Rhabdomyolysis and Hepatotoxicity
Amrinone and milrinone
10. These agents are CNS depressants
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Ethanol - Barbiturates - and Benzodiazepines
Bromocriptine
Anterograde amnesia
11. Distribution of histamine receptors H1 - H2 - and H3
Dry cough - hyperkalemia
Flutamide (Eulexin)
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Phentolamine
12. Class of drugs with ability to decrease the maximal response to an agonist
Noncompetitive antagonist
Estrogen
Atrial fibrillation and CHF
Pilocarpine
13. Opioid antagonist that is given IV and had short DOA
Letrozole - anastrozole
Naloxone
Acyclovir; incorporated into viral DNA and chain termination
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
14. SE of OCs
Increased thromboembolic events
Long acting cholinesterase inhibitors
Degradation of fibrin clots and are administered IV
Cyproterone acetate
15. Dopamine agonist used in hyperprolactinemia
Increase the DURATION of GABA- mediated chloride ion channels
Bromocriptine
Neuromuscular blocking drugs
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
16. Another pneumonic for anticholinergic toxicity
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17. SE of imipenem
Olanzapine
Bethanechol
Seizures
Atropine - homatropine - C1208 tropicamide
18. Most inhaled anesthetics SE
Ketamine
Decrease arterial blood pressure
Nateglinide
Disulfiram - like reaction
19. Neurotransmitters affected by the action of antidepressants
Pamidronate - zoledronate - ibandronate
Beta - blockers
Methotrexate
Norepinephrine and serotonin
20. Loops lose and thiazide diuretics retain
Bradykinin and histamine
Calcium
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Amphetamines
21. Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis
Valproic acid - carbamazepine - phenytoin and gabapentin
Sodium bicarbonate
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Desmopressin (DDAVP)
22. 2nd generation antihistamines
Fexofenadine - loratadine - and cetirizine
Rhabdomyolysis and Hepatotoxicity
Constipation - edema - and headache
Diphendydramine
23. Antidote for arsenic - mercury - lead - and gold poisoning
Levodopa
Mirtazapine
Dimercaprol
Glomerulosa (mineralocorticoids) - fasciculata (glucocorticoid=GC) - and reticularis (adrenal androgens)
24. Anti - arrhythmics that decrease mortality
Doxepin
B- blockers
Glucagon
Miosis and constipation
25. Regimen used for breast cancer
Amitriptyline
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Additive CNS depression
Low therapeutic index
26. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Valproic acid - carbamazepine - phenytoin and gabapentin
Chlorpropamide
ORAL vancomycin
Phase I
27. Other side effects of Quinidine
Long acting cholinesterase inhibitors
Benzodiazepines and calcium channel blockers
Ethinyl estradiol and mestranol
Thrombocytopenic purpura - and CINCHONISM
28. Sedative - Hypnotics action
Reduce inhibition - suppress anxiety - and produce relaxation
Thiopental
Cephalosporins
Hallucinations resembling psychosis
29. Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)
Dopamine blockade
Partial agonist
Flumazenil
Bile acid - binding resins
30. Anemia caused by trimethoprim
Ethosuximide and valproic acid
Megaloblastic anemia
Oxidation - reduction - hydrolysis
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
31. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure
Phenoxybenzamine
Vitamin K or fresh frozen plasma
Nefazodone
Adenosine
32. Anti - seizure agent that exhibits non - linear metabolism - highly protein bound - causes fetal hydantoin syndrome - and stimulates hepatic metabolism
Rifampin
Dopamine
Phenytoin
Gingival hyperplasia
33. Opioid antagonist that is given orally in alcohol dependency programs
Insulin
Naltrexone
Etidronate
Atrial fibrillation and CHF
34. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients
Low therapeutic index
Toremifene (Fareston)
Selegiline
100% O2 and hyperbaric O2
35. Difference between COX 1 and COX 2
Sumatriptan - naratriptan - and rizatriptan
Cyanide toxicity treated with sodium thiosulfate
Penicillamine
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
36. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
Arginine
Levodopa
GABA- related targets
Dexamethasone suppression test
37. Beta blockers are used for which type of anginal attack
Dimercaprol - EDTA
Vancomycin
Classic
Ticlopidine
38. Drugs decrease intestinal absorption of cholesterol
Bile acid - binding resins
Odansetron - granisetron
Indomethacin
Side - effect profile and prior pt response
39. Drug used for MRSA
Glucagon
Entacapone and Tolcapone
Osteoporosis - Paget's disease - and osteolytic bone lesions - and hypercalcemia from malignancy
Vancomycin
40. Radio contrast media that inhibits the conversion of T4 to T3
Infants - closed angle glaucoma - prostatic hypertrophy
Succinylcholine
Kidneys
Ipodate
41. Pneumonic for 3 zones of adrenal cortex
Hypercalcemia
Decreases hepatic glucose production and intestinal glucose absorption; increase insulin sensitivity
GFR
Infliximab
42. Benzodiazepine used adjunctively in anesthesia
Etidronate
B- blockers
Midazolam
Metformin
43. Fluoride released by metabolism of this inhaled anesthetic may cause renal insufficiency
LSD
Partial agonist
Albuterol
Methoxyflurane
44. Occurs when sedative hypnotics are used chronically or at high doses
Tolerance
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
Hypercalcemia
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
45. Skeletal muscle agent that can block muscarinic receptors
Aztreonam
Hypertensive crisis
Reduce the loss from area of injection
Pancuronium
46. TCA used in obsessive compulsive disorder (OCD) - most significant of TCA's for risk of seizure - weight gain - and neuropsychiatric signs and symptoms
Inhibits osteoclast bone resorption
Adrenal suppression and weaning slowly - respectively
Clomipramine
Organic nitrites
47. Anticoagulant of choice in pregnancy
Heparin
Desmopressin (DDAVP)
Prednisone
Clopidogrel and ticlopidine
48. MOA of general anesthetics
L- thyroxine (T4)
Most are thought to act at GABA- A receptor - chloride channel
6- mercaptopurine (6- MP)
Cocaine
49. Toxicity caused by nitroprusside and treatment
Tizanidine
Edrophonium
Ephedrine
Cyanide toxicity treated with sodium thiosulfate
50. NSAID also available as an ophthalmic preparation
B- blockers
Classic
Phenytoin
Diclofenac - ketoralac