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USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
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Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. LA causing methemoglobinemia
Prilocaine
Gynecomastia hyperkalemia - and impotence
Phenytoin
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'
2. ABVD regimen used for HD - but appears less likely to cause sterility and secondary malignancies than MOPP
Acetazolamide
Morphine and fentanyl
Didanosine
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
3. Anti - androgen used for prostate cancer
Cocaine and benzocaine
Flumazenil
Estogens increase maternal TBG
Flutamide (Eulexin)
4. Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis
Albuterol
LFT's
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Antipyretic and analgesic activity
5. Interact with microtubules (but unlike vinca which prevent disassembly of tubules) - it stabilizes tubulin and cells remain frozen in metaphase
Radioactive iodine
Finasteride (Proscar and Propecia respectively)
Benzodiazepines and calcium channel blockers
Paclitaxel (taxol)
6. Newer NSAID that selectively inhibits COX-2
Liver toxicity
Phenoxybenzamine
Celecoxib
Ephedrine
7. Anti - rheumatic agent also used for ulcerative colitis
Glucocorticoids
Sulfasalazine
Desflurane
increase the FREQUENCY of GABA- mediated chloride ion channel opening
8. Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA
Halothane and methoxyflurane
Dexrazoxane
Tissue plasmin activator
Metronidazole
9. SE of nitrates
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Penicillamine
Oral
Hot flashes
10. Drug of choice for myoclonic seizures
Valproic acid
Alkalinize urine - dialysis
Aplastic anemia and acute hepatic failure
Physostigmine
11. Side effects occuring in antipsychotics that block dopamine
Flumazenil
Disulfiram - like reaction
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Methotrexate
12. Presynaptic Alpha 2 agonist used in HTN - and acts centrally
Mast cell stabilizer
Cephalosporins
Clonidine - and methyldopa
Dextroamphetamines and methamphetamine
13. Meglitinide class of drugs
Hypertensive crisis
Repaglinide
Affect calcium - potassium - and sodium channels
Abciximab - tirofiban and eptifibatide
14. Drug causing depletion of substance P (vasodilator)
Capsaicin
Clomipramine
Ethanol - fomepizole
Cardiac anomalies and is contraindicated in pregnancy or lactation
15. Class of drugs that reversibly inhibit COX
Glyburide - glipizide - and rosiglitazone
Interferon alpha
Acarbose - miglitol
NSAIDS
16. Limiting side effect of Quinidine
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Prolongs QT interval
Sedation
Use in IgE mediated allergic reaction
17. Prolonged exposure to this inhaled anesthetic may lead to megaloblastic anemia
Zollinger - Ellison Syndrome
hydroxyzine (Atarax)
Efficacy
Nitrous oxide
18. Drug used in Chagas disease
Carbidopa
Gabapentin
Buspirone
Nifurtimox
19. Estrogen mostly used in oral contraceptives (OC)
Ethinyl estradiol and mestranol
Haloperidol
Ipodate
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
20. Anti - seizure medication also used in the prevention of migraines
Alprazolam
Streptokinase
Minoxidil
Valproic acid
21. Agent that is teratogen and causes a fetal syndrome
Adalimumab - infliximab and etanercept
Lupus - like syndrome
Leuprolide
Ethanol
22. Vitamin K dependent anticoagulant
Presynaptic mu - delta - and kappa receptors
Ganciclovir - zidovudine - saquinavir - and interferon
Aspirin
Warfarin (PT)
23. Agent used for neurological deficits in megaloblastic anemia
Arteries and veins
Bupropion
Epinephrine
Vitamin B12
24. Anti - microbials that cause hemolysis in G6PD- deficient patients
Valproic acid and Phenytoin
Inhibit Cytochrome P450 3A4
Codeine - hydrocodone - and oxycodone
Sulfonamides
25. Antidote used for heparin overdose
Relax vascular smooth muscle - at low doses dilate veins and at high doses dilate arterioles
Miosis and constipation
Benztropine - trihexyphenidyl
Protamine
26. Causes acne - premature closure of epiphyses - masculinization in females - hepatic dysfunction - MI - and increases in libido and aggression
inhibits Na+/K+/2Cl - cotransport
Steroids
Fluoxetine
Miosis and constipation
27. Toxicity of organophosphate:
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Scotch tape technique and mebendazole
Hypoglycemia
Chlorpheniramine or cyclizine
28. Clinical use for H2 blockers
Abciximab - tirofiban and eptifibatide
Ondansetron - granisetron - dolasetron and alosetron
Ephedrine
Acid reflux disease - duodenal ulcer and peptic ulcer disease
29. Dopamine (DA) agonist (for Parkinson's disease) - used also for hyperprolactinemia
Glucagon
C- peptide
Steroids
Bromocriptine
30. Selectivity of a drug for its receptor
Postsynaptic Mu receptors
Clopidogrel and ticlopidine
Aldehyde dehydrogenase
Specificity
31. Cardioselective Beta 1- blockers
Atenolol - acebutolol - and metoprolol
Liver enzyme INDUCTION
Odansetron
Ketoralac
32. Ability to produce less than 100% of the response
Partial agonist
Thyroxine
Niacin
Infliximab
33. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea
Labetalol and carvedilol
Insulin secretagogue - closes ATP- sensitive K+ channel
Ipratropium
Zollinger - Ellison Syndrome
34. Produce mydriasis and cycloplegia
Atropine - homatropine - C1208 tropicamide
Ganciclovir
Thiopental
Aplastic anemia and renal toxicity
35. Cystitis - postoperative bladder spasms - or incontinence
Thiopental
Dantrolene
Long acting cholinesterase inhibitors
Oxybutynin - dicyclomine
36. Antidote used for methanol and ethylene glycol
Hyperprolactinemia - menorrhea - galactorrhea - confusion - mood changes - decreased sexual interest - and weight gain
Doxepin
Ethanol or fomepizole
Epinephrine
37. Cephalosporin causes kernicterus in neonates
Ceftriaxone or cefuroxime
Prostaglandin PGF2a
Dantrolene
Albuterol
38. Chelating agent used in acute iron toxicity
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Deferoxamine
Pulmonary embolism and DVT
pregnancy and with K+
39. Nitrosoureas with high lipophilicity - used for brain tumors
Nitrites
Carmustine (BCNU) and lomustine (CCNU)
Meperidine
NO - chloroform - and diethyl ether
40. Anti - psychotics available in depot preparation
Skeletal muscle tremor - tachycardia
Amiodarone
L- asparaginase
Fluphenazine and haloperidol
41. Common side effect of Rifampin
Red urine discoloration
Most are thought to act at GABA- A receptor - chloride channel
Affect calcium - potassium - and sodium channels
Amiodarone
42. This beta blocker is the longest acting
Constipation - edema - and headache
Rebound HTN - sedation - dry mouth
Ascending pathways
Nadolol
43. SE for ticlopidine
Cocaine
Cimetidine
Neutropenia and agranulocytosis
Hallucinations resembling psychosis
44. SSRI less likely to cause a withdrawal syndrome
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Propranolol
Fluoxetine
Elderly patients
45. Antidote used for benzodiazepine toxicity
Amiodarone
Flumazenil
DOM - STP - MDA - and MDMA 'ecstasy'
Most are thought to act at GABA- A receptor - chloride channel
46. Antidote for acetaminophen toxicity
Nondepolarizing type antagonists
N- acetylcysteine
Autocoids
Thiopental
47. Enhances dopaminergic neurotransmission SE's include CNS excitation - acute toxic psychosis and livedo reticularis
Nitrous oxide
PCP
Amantadine
Lepirudin
48. Common toxicities of cisplatin
Nephro and ototoxicity
ACE inhibitors
Rhabdomyolysis
Ethosuximide and valproic acid
49. Class of drugs that may cause cross - sensitivity with thiazide diuretics
Oxytocin - ergonovine and ergotamine
Benztropine
Insulin glargine
Sulfonamides
50. These agents are used as antidiarrheal
CHOP (cyclophosphamide - doxorubicin - vincristine - and prednisone) plus rituximab
Diphenoxylate - Loperamide
Dimenhydrinate - meclizine - and other 1st generation
Carvedilol
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