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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Neurologic SE of benzodiazepines
Atenolol - acebutolol - and metoprolol
Hepatic toxicity
Anterograde amnesia
Ganciclovir - zidovudine - saquinavir - and interferon
2. This agent used to treat dry mouth in Sj
Normal C- peptide
Penicillamine
Cevimeline
Heroin - morphine - oxycodone - meperidine and fentanyl
3. SE for ticlopidine
Methadone
Pregnancy
Neutropenia and agranulocytosis
Vitamin B12
4. HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
Liver toxicity - increased serum cholesterol
Tizanidine
Protease inhibitors
Cevimeline
5. SE of spironolactone
Morphine
Etidronate
Mifepristone
Gynecomastia hyperkalemia - and impotence
6. DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics
Potassium channel blockers
Drug induced Parkinsonism
Steady state
Dantrolene
7. Cause dizziness - tachycardia - hypotension - and flushing
Malathion
Organic nitrites
Cyproheptadine
Codeine - hydrocodone - and oxycodone
8. Reversal of blockade by neuromuscular blockers
Lepirudin
Methotrexate
Cholinesterase inhibitors
Desmopressin (DDAVP)
9. Median toxic dose required for a toxic effect in 50% of the population
TD50
Reduce inhibition - suppress anxiety - and produce relaxation
Olanzapine
PGE1
10. Toxicity of these agents include bradycardia - AV blockade - exacerbation of acute CHF; signs of hypoglycemia may be masked (tachycardia - tremor - and anxiety)
Stevens - Johnson syndrome
Amiodarone
IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
Beta blockers
11. A hormone whose mechanism of action (MOA) utilizes intracellular receptors
Enflurane and halothane
Bleomycin - vinca alkaloids - antimetabolites (eg. - 5- FU - 6- MP - methotrexate - etoposide)
Hydralazine
Thyroid and steroid hormones
12. Only phenothiazine not exerting antiemetic effects - can cause visual impairment due to retinal deposits - and high doses have been associated with ventricular arrhythmias
Tetracaine and bupivacaine
Hot flashes
Thioridazine
Morphine
13. DOC for CMV retinitis
Ganciclovir
Carbidopa
Epinephrine
Tolerance
14. Antidote used for carbon monoxide poisoning
Bile acid - binding resins
100% O2 and hyperbaric O2
COX 1 is found throughout the body and COX 2 is only in inflammatory tissue
Labetalol and carvedilol
15. Permanently cures thyrotoxicosis - patients will need thyroid replacement therapy thereafter. Contraindicated in pregnancy
Morphine
Beta - blockers such as propranolol
Chlordiazepoxide and Diazepam
Radioactive iodine
16. Reduced seizure threshold
Blocks peptidoglycan synthesis
Pralidoxime
Low - potency typical antipsychotics and clozapine
Rescue therapy
17. Facilitates GABA presynaptic inhibition
Clonazepam
Calcium
Diazepam
Atrial fibrillation and CHF
18. Increased risk of developing cataracts
Haloperidol or pimozide
Pulse therapy
IV administration
Quetiapine
19. Beta 2 agonist used to suppress premature labor - but cardiac stimulatory effects may be hazardous to mother and fetus
Terbutaline
Pulse therapy
block SLUD (salivation - lacrimation - urination - defecation
Valproic acid
20. Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis
Cefixime (3rd) generation
Cocaine 'super - speed'
Chlorpheniramine or cyclizine
Desmopressin (DDAVP)
21. Allopurinol treats chronic gout by decreasing uric acid production by inhibiting
Cutaneous flush
Xanthine oxidase
Amiodarone
Parathion
22. Used intravenously for acute arrhythmias during surgery
Fluphenazine and haloperidol
Esmolol
Prednisone
Chlorpheniramine or cyclizine
23. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Flutamide (Eulexin)
Halothane and methoxyflurane
Aminoglutethimide
Overdose of opioids
24. Receptors for serotonin (5HT-1) are located
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Antipyretic and analgesic activity
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Adenosine
25. Prototypical drug is atropine
Prazosin - terazosin - doxazosin
Tinnitus - GI bleeding
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Nonselective Muscarinic Antagonists
26. The elimination of drug that occurs before it reaches the systemic circulation
Gingival hyperplasia
Ganciclovir - zidovudine - saquinavir - and interferon
First pass effect
Cartilage damage
27. Dopamine agonist used in hyperprolactinemia
Skeletal muscle tremor - tachycardia
Bromocriptine
CNS stimulation; GI upset
Streptomycin
28. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Benztropine
Midazolam
Bromocriptine
Valproic acid
29. Newer NSAID that selectively inhibits COX-2
Arginine
Blocks peptidoglycan synthesis
Celecoxib
Agranulocytosis
30. Aspirin is contraindicated in children with viral infection
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31. Drug causing depletion of substance P (vasodilator)
Hyperuricemia - hypokalemia and ototoxicity
Pramipexole and ropinirole
Low therapeutic index
Capsaicin
32. These agents are CNS depressants
Clomipramine - fluoxetine and fluvoxamine
Ethanol or fomepizole
Valproic acid - carbamazepine - phenytoin and gabapentin
Ethanol - Barbiturates - and Benzodiazepines
33. Drugs of choice for absence seizures
inhibits HMG COA reductase
Ethosuximide and valproic acid
Ketoralac
Cutaneous flush
34. Agent to treat hypochromic microcytic anemias
Mast cell stabilizer
Ferrous sulfate
Neuroleptanesthesia
Trazodone
35. Selective Alpha -1A blocker - used for BPH - but with little effect on HTN
Celecoxib and rofecoxib
Pilocarpine - carbachol - physostigmine
Tamsulosin
Regular (Humulin R)
36. Very rapid acting insulin - having fastest onset and shortest duration of action
Epinephrine
Lispro (Humalog) - aspart - glulisine
Blocks peptidoglycan synthesis
Raloxifene
37. Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
DOM - STP - MDA - and MDMA 'ecstasy'
Etidronate
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
38. Prototype antagonist of H1 and H2 receptors
Diphenhydramine and cimetridine - respectively
Ferrous sulfate
Mannitol
Allopurinol
39. Lactam that can be used in PCN allergic patients
Aztreonam
Increase the DURATION of GABA- mediated chloride ion channels
Glargine (Lantus) - detemir
Bromocriptine
40. SSRI less likely to cause a withdrawal syndrome
Fluoxetine
Fluorocarbons and Industrial solvents
Odansetron
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
41. Antidote for beta - blockers and hypoglycemia
Dantrolene
Malathion
Chlorpropamide
Glucagon
42. MOA of class IV antiarrhythmics
Sumatriptan
Inhibit DNA gyrase
Calcium channel blockers
Carboplatin
43. Muscarinic antagonist used in asthma
Terbutaline
Ipratropium
Desmopressin (DDAVP)
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
44. This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Fentanyl
Timolol
Elderly patients
Diphendydramine
45. Non - selective Beta - blocker also used for migraine prophylaxis
Propranolol
Hypoglycemia
B- blockers
Dipyridamole
46. Used for SIADH
Pramipexole and ropinirole
Caffeine
Positive Comb's test - depression
Demeclocycline
47. Vitamin given with calcium to ensure proper absorption
Vitamin D
Flumazenil
Diethylstilbestrol (DES)
Hypertension
48. Opioid antagonist that is given orally in alcohol dependency programs
Steroids
Tertiary amines
Caffeine
Naltrexone
49. Benzodiazepine that is used for anesthesia
Midazolam
nephro and ototoxicity
Adrenal suppression and weaning slowly - respectively
Esmolol
50. Mineralocorticoids
Leuprolide
Fluphenazine and haloperidol
Scotch tape technique and mebendazole
Fludrocortisone and deoxycorticosterone