SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Side effects frequently seen with SSRIs
Combination oral contraceptives (OC)
Cyclophosphamide
CNS stimulation; GI upset
Tertiary amines
2. Aspirin is contraindicated in children with viral infection
Warning
: Invalid argument supplied for foreach() in
/var/www/html/basicversity.com/show_quiz.php
on line
183
3. Agent used to treat chronic gout by increasing uric acid secretion and excretion
Carbenicillin - piperacillin and ticarcillin
Degradation of fibrin clots and are administered IV
Older antipsychotics
Probenecid and sulfinpyrazone
4. Vitamin given with calcium to ensure proper absorption
Vitamin D
Succinylcholine
Lispro (Humalog) - aspart - glulisine
Phentolamine
5. SE seen only in men with administration of ketoconazole
Iodide salts
Gabapentin
Gynecomastia
Mivacurium
6. Interact with microtubules (but unlike vinca which prevent disassembly of tubules) - it stabilizes tubulin and cells remain frozen in metaphase
Tolerance
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Paclitaxel (taxol)
Tamsulosin (Flomax)
7. Used for SIADH
Vasodilation
L- dopa
Nitrous oxide
Demeclocycline
8. Site of action of loop diuretics
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Atenolol - acebutolol - and metoprolol
Thick ascending limb
Tertiary amines
9. Drug used in ergot alkaloids overdose - ischemia and gangrene
Autocoids
Nitroprusside
Valproic acid - carbamazepine - phenytoin and gabapentin
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
10. SE of hydroxychloroquine
Clozapine
Bromocriptine
St. Anthony's Fire
Retinal destruction and dermatitis
11. SE of Amiodarone
Vancomycin - infusion at a slow rate and antihistamines
DUMBELSS (diarrhea - urination - miosis - bronchoconstriction - excitation of skeletal muscle and CNS - lacrimation - salivation - and sweating)
Glucocorticoids
Cardiac dysfunction - photosensitivity - skin (blue smurf syndrome) - Pulmonary fibrosis - thyroid and corneal deposits
12. These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Beta1 agonists
Malathion
Peripheral neuritis and hepatitis
Iron deiodinates thyroxine
13. Anti - Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
Ipratropium
Levodopa
Propranolol
Aldehyde dehydrogenase
14. Inhibit angiotensin - converting enzyme (ACE)
Phenoxybenzamine
ACE inhibitors
Zero order kinetics
Glyburide - glipizide - glimepiride - etc.
15. SE of penicillamine
Atropine
Chemical esophagitis
block SLUD (salivation - lacrimation - urination - defecation
Aplastic anemia and renal toxicity
16. SSRI indicated for premenstrual dysphoric disorder
Fluoxetine (Sarafem)
Bupropion
Buprenorphine
Esmolol
17. MOA of both generations
Dimenhydrinate - meclizine - and other 1st generation
Insulin release from pancreas by modifying K+ channels
Aplastic anemia and renal toxicity
Dantrolene
18. Antidote used for cyanide poisoning
Decrease arterial blood pressure
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Nitrites
Cisplatin
19. Skeletal muscle agent that can block muscarinic receptors
Pancuronium
Pyridostigmine
Carboplatin
Hepatotoxicity
20. Agent that inhibits alcohol dyhydrogenase and its clinical use
Low therapeutic index
Excessive hypotension and kidney failure
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Sodium channel blockers
21. Toxicity of these agents include bradycardia - AV blockade - exacerbation of acute CHF; signs of hypoglycemia may be masked (tachycardia - tremor - and anxiety)
Decreases protein synthesis by inhibiting 30S ribosome
Hallucinations resembling psychosis
Insulin release from pancreas by modifying K+ channels
Beta blockers
22. MOA of nateglinide
Nondepolarizing type antagonists
Volume of distribution (VD)
Dimercaprol
Insulin secretagogue - closes ATP- sensitive K+ channel
23. Very rapid acting insulin - having fastest onset and shortest duration of action
Constipation - edema - and headache
Nitrous oxide
Lispro (Humalog) - aspart - glulisine
Odansetron - granisetron
24. MOA of loop diuretics
Insulin secretagogue - closes ATP- sensitive K+ channel
Nitrous oxide
Serotonin syndrome
inhibits Na+/K+/2Cl - cotransport
25. Agent that inhibits hepatic metabolism - is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
Radioactive iodine
Nitrous oxide
Valproic acid
Propranolol
26. Antipsychotics that reduce positive symptoms only
Minocycline
Older antipsychotics
Sinus tachycardia and serious arrhythmias
Tamsulosin (Flomax)
27. Arterial vasodilator that works by opening K+ channels
Minoxidil
Decreased micro and macro vascular disease
nephro and ototoxicity
Metronidazole
28. Most important potential SE of metformin
Lactic acidosis
Dextroamphetamines and methamphetamine
Phenytoin
Diphendydramine
29. Lacrimation - rhinorrhea - yawning - sweating - weakness - gooseflesh - nausea - and vomiting - tremor - muscle jerks - and hyperpnea are signs of this syndrome
Bind ergosterol in fungal cell membrane
Abstinence syndrome
Xanthine oxidase
Esmolol
30. Reason fluoroquinolones are contraindicated in children and pregnancy
PTU
Cartilage damage
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Buspirone
31. Antipsychotic having the strongest autonomic effects
Digibind (also need to d/c digoxin - normalize K+ - and lidocaine if pt. Is arrhythmic)
Nitrous oxide
Thioridazine
Ethanol - fomepizole
32. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors
Octreotide
Aldehyde dehydrogenase
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Dopamine
33. Antidepressant having stimulant effects similar to SSRI's and can increase blood pressure
Hydralazine
Dexamethasone suppression test
Terfenadine and astemizole (have been removed from the market)
Venlafaxine
34. SE of tPA
Glucocorticoids
Pulse therapy
Organic nitrites
Cerebral hemorrhage
35. Warfarin is contraindicated in
Mechlorethamine
Rescue therapy
Protamine
Pregnancy
36. Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage - cardiac arrhythmias - and myocardial infarction
Beta1 agonists
Rhabdomyolysis
Potency
Cocaine
37. Irreversible condition resulting from the use of antipsychotics - reserpine at high doses - and MPTP (by- product of illicit meperidine analog)
Selective inhibitor of microtubule assembly
Drug induced Parkinsonism
Carvedilol
Affect calcium - potassium - and sodium channels
38. Fibrates are contraindicated in
Prolonged half - life - up to six weeks
Phenobarbital
Nitrites
Pregnancy
39. Used for Cushing's syndrome (increased corticosteroid)
Constipation - edema - and headache
Hypokalemia
Alprostadil
Dexamethasone suppression test
40. Reduce transient hyper GI motility
Dicyclomine - methscopolamine
Timolol
Clopidogrel and ticlopidine
Ethanol
41. MOA of aspirin
Halothane and methoxyflurane
Irreversibly blocking cyclooxygenase
Carboplatin
Antipyretic and analgesic activity
42. Anti - psychotic not shown to cause tardive dyskinesia
L- dopa
Hypoglycemia
Valproic acid
Clozapine
43. Treatment for TB patients (think RIPE)
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Tricyclic antidepressants (TCA)
Nephrotoxicity
Cyclophosphamide
44. Antidote for digoxin toxicity
Benztropine - trihexyphenidyl
Metronidazole
Atropine - pralidoxime (2- PAM)
Digibind
45. DOC for tx of pseudomembranous colitis
Lepirudin
Tetracycline
PTU
Metronidazole
46. Available bisphosphonates
Thioridazine
Methotrexate
Ondansetron - granisetron - dolasetron and alosetron
Alendronate - etidronate - risedronate - pamidronate - tiludronate - and zoledronic acid
47. Amphetamine agents
Vasodilation
Ethanol - Barbiturates - and Benzodiazepines
Ethanol
Dextroamphetamines and methamphetamine
48. Effective in preventing TIA's
Dextromethorphan - Codeine
Clopidogrel and ticlopidine
Apraclonidine - brimonidine
Fluphenazine and haloperidol
49. MOA of Bisphosphonates
Rhabdomyolysis
Tetracaine and bupivacaine
Antithrombin 3
Inhibits osteoclast bone resorption
50. Neurologic SE of benzodiazepines
Anterograde amnesia
Blocks peptidoglycan synthesis
Torsades de pointes
Methotrexate