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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Approved for use in severe pulmonary HTN
Insulin
Tetrabenazine (amine depleting drug) - Haloperidol (antipsychotic)
PGI2 (epoprostenol)
Low therapeutic index
2. Converts asparagine to aspartate and ammonia - denies cancer cells of essential AA (asparagine)
Dolasetron
Warfarin (PT)
L- asparaginase
Low - potency typical antipsychotics and clozapine
3. Digoxin toxicity can be precipitated by
Gynecomastia
Abstinence syndrome
Hypokalemia
Folic acid
4. Prolonged exposure to this inhaled anesthetic may lead to megaloblastic anemia
Aspirin - metoprolol
Nitrous oxide
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Mirtazapine
5. Similar to clonidine and may cause hypotension
CMF (cyclophosphamide - methotrexate - and fluorouracil) and tamoxifen if ER+
Somatrem
Leucovorin
Tizanidine
6. The selective agents loose their selectivity at
Indomethacin
Norepinephrine and serotonin
high doses
Increased thromboembolic events
7. Agent to treat hypochromic microcytic anemias
Ketanserin cyproheptadine - and phenoxybenzamine
Ferrous sulfate
Prednisone
Folic acid
8. Hormone inhibiting prolactin release
Odansetron - granisetron
Potency
Dopamine
Antipyretic and analgesic activity
9. Increase bone density - also being tested for breast CA prophylaxis
Raloxifene (SERM- selective estrogen receptor modulator)
Timolol
Streptomycin
Thrombocytopenia
10. Nitrate free intervals are needed due to
Nortriptyline - Desipramine
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Tolerance
Protease inhibitors
11. Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs
Alprazolam
Nicotine
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Chlordiazepoxide and Diazepam
12. Agent used in CHF that is a selective alpha and nonselective beta blocker
Carvedilol
Affect calcium - potassium - and sodium channels
Physostigmine
Atrial fibrillation and CHF
13. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
Low - potency typical antipsychotics and clozapine
Ability to cross the placenta
L- dopa
LSD
14. This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention
Norepinephrine and serotonin
Zero order kinetics
Bethanechol
Acetazolamide
15. Initial DMARD of choice for patients with RA
Glucocorticoids
Allopurinol
Methotrexate
Calcium
16. Most common side effect of 1st generation antihistamines
Loading dose (Cp*(Vd/F))
Nausea
Sedation
Phenobarbital
17. Agent used for megaloblastic anemia (but does Not reverse neurologic symptoms) and decrease neural tube defects during pregnancy
TD50
Folic acid
DOM - STP - MDA - and MDMA 'ecstasy'
Pregnancy
18. Produces disulfiram - like reaction with ethanol
Chemical esophagitis
Kidneys
Procarbazine
Chlordiazepoxide and Diazepam
19. Alpha 1selective blockers
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
None
20. Site of action of thiazide diuretics
Retinal destruction and dermatitis
Bile acid - binding resins
Work at early distal convoluted tubule
Potency
21. Only member of depolarizing neuromuscular blocker - causes fasciculation during induction and muscle pain after use; has short duration of action
Cartilage damage
Liver toxicity - increased serum cholesterol
Increasing sodium excretion and decreases arterial and venous tone
Succinylcholine
22. Second generation sulfonylurea
Cyanocobalamin (Vit B12)
Ketanserin cyproheptadine - and phenoxybenzamine
Caffeine
Glyburide - glipizide - glimepiride - etc.
23. Period of time of therapy after which GC therapy will need to be tapered
Naloxone (IV) - naltrexone (PO)
5-7 days
Nesiritide (BNP)
Beta - blockers such as propranolol
24. First generation sulfonylurea
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
First pass effect
Chlorpropamide - tolbutamide - tolazamide - etc.
25. What do beta cells in the pancreas produce?
Buspirone
Hypokalemia
Trazodone
Insulin
26. Treatment for TB patients (think RIPE)
Antithrombin 3
Rifampin - Isoniazid - Pyrazinamide - and Ethambutol
Warfarin (PT)
Estogens increase maternal TBG
27. Names of three bisphosphonates available IV
Caffeine
Tissue plasmin activator
Alkylating agents (eg. - mechlorethamine - cyclophosphamide) - antibiotics (doxorubicin - daunorubicin) - cisplatin - nitrosourea
Pamidronate - zoledronate - ibandronate
28. Sulfonylurea Not recommended for elderly because of very long half life
Chlorpropamide
Sedation
Dopamine
Dimercaprol
29. MOA of nateglinide
LSD
Insulin secretagogue - closes ATP- sensitive K+ channel
Celecoxib
Alpha1 agonists
30. Diuretic used to antagonize aldosterone receptors
Tamoxifen
Postural hypotension - reflex tachycardia - hot flashes - and throbbing headache due to meningeal artery dilation
Spironolactone
Agranulocytosis
31. Agent similar to cisplatin - less nephrotoxic - but greater myelosuppression
Carboplatin
Tremor - sedation - ataxia - aphasia - thyroid enlargement - and reversible diabetes insipidus
Lithium toxicity
Degradation of fibrin clots and are administered IV
32. CCB with predominate effect on arteriole dilation
Ticlopidine
Nifedipine
Primaquine
Cyanide toxicity treated with sodium thiosulfate
33. Agents that reduce heart rate - contractility - and O2 demand
Beta - blockers
Thyroid and steroid hormones
Bind ergosterol in fungal cell membrane
Procarbazine
34. MOA of general anesthetics
Most are thought to act at GABA- A receptor - chloride channel
Amiodarone
Hot flashes
Esmolol
35. Vascular effects of metformin
Glucuronate - acetic acid - and glutathione sulfate
Inhibit DNA gyrase
Ceftriaxone
Decreased micro and macro vascular disease
36. Monitoring parameter to obtain before initiation of STATINS
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37. Selective Alpha 1 blocker used for hypertension - BPH - may cause first dose orthostatic hypotension
Deferoxamine
Gastric ulcers and GI Bleeding
Affinity
Prazosin - terazosin - doxazosin
38. MOA of repaglinide
Hepatic toxicity
Nephro and ototoxicity
Insulin release from pancreas; faster and shorter acting than sulfonylurea
Edema - mild anemia; interaction with drugs that undergo CytP450 3A4 metabolism
39. Most common SE of fibrates
Citalopram and its metabolite escitalopram
Tizanidine
Nausea
Hepatic
40. Radio contrast media that inhibits the conversion of T4 to T3
Ipodate
Kidney and liver toxicity - diarrhea
Interferon alpha
Steroids
41. Prevents thrombosis in patients with artificial heart valve
Arteries and veins
Most are thought to act at GABA- A receptor - chloride channel
Block voltage - dependent sodium channels
Dipyridamole
42. Adenosine's MOA
Yohimbine
Flumazenil
Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
Hypokalemia
43. Inhaled anesthetics are myocardial depressants
Bethanechol
Gingival hyperplasia - nystagmus - diplopia and ataxia
Propranolol
Enflurane and halothane
44. Class of drugs with ability to decrease the maximal response to an agonist
Class IC (flecainide - propafenone - moricizine)
Nesiritide (Natrecor)
Meperidine
Noncompetitive antagonist
45. Route of administration of warfarin
Oral
Raloxifene
Digibind
Nitrites
46. H1 blocker that is also a serotonin antagonist
Fentanyl
Ondansetron - granisetron - dolasetron and alosetron
Aminocaproic acid
Cyproheptadine
47. Common SE of tamoxifen and raloxifene
Aminoglutethimide
Hot flashes
Classic
Aspirin - Nitrates - CCB - and Beta blockers
48. Concentration in the plasma times (clearance divided by bioavailability)
Maintenance dose (Cp*(CL/F))
Flumazenil
Cocaine and benzocaine
Insulin secretagogue - closes ATP- sensitive K+ channel
49. Agent that is teratogen and causes a fetal syndrome
Ezetimibe (Zetia)
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
Ethanol
Patches - gum - nasal spray - psychotherapy - and bupropion
50. Cephalosporins able to cross the BBB
Aspirin
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone
Aldehyde dehydrogenase
Sodium channel blockers