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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Barbiturates may precipitate this hematologic condition
Acute intermittent porphyria
Verapamil
Cartilage damage
Cimetidine
2. Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
Full agonist
Prostaglandin PGF2a
Adalimumab - infliximab and etanercept
L- dopa
3. Triptan available in parenteral and nasal formulation
Chemical esophagitis
Sumatriptan
Sulfonamides
Monamine oxidase inhibitors
4. Antidote used for tricyclic antidepressants (TCA)
Affect calcium - potassium - and sodium channels
Acetazolamide
Esmolol
Sodium bicarbonate
5. Antiplatelet drug reserved for patients allergic to aspirin
Tricyclic antidepressants (TCA)
Glyburide - glipizide - glimepiride - etc.
Ticlopidine
Hepatotoxicity
6. The selective agents loose their selectivity at
Aspirin irreversibly inhibits cyclooxygenase
high doses
Raloxifene
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin
7. Nitrate used for acute anginal attacks
Phentolamine
Nitroglycerin sublingual tablets
Esmolol
Diclofenac - ketoralac
8. Toxicity of amphotericin
Methadone
Levodopa
5-7 days
Nephrotoxicity
9. DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics
Aplastic anemia and acute hepatic failure
Dantrolene
Apraclonidine - brimonidine
Impair absorption of fat soluble vitamin absorption (A - D - E - K)
10. Converts asparagine to aspartate and ammonia - denies cancer cells of essential AA (asparagine)
Marijuana
L- asparaginase
Allopurinol
Clozapine
11. These agents are CNS depressants
Monamine oxidase inhibitors
Acetazolamide
Ethanol - Barbiturates - and Benzodiazepines
Cutaneous flush
12. SE for Felbamate
Neostigmine
Epinephrine
Aplastic anemia and acute hepatic failure
Hydroxychloroquine
13. Cephalosporins Not able to cross the BBB
Cyclophosphamide
Naloxone (IV) - naltrexone (PO)
Cholinesterase inhibitors
Cefixime (3rd) generation
14. Reduced seizure threshold
Cyproterone acetate
Low - potency typical antipsychotics and clozapine
Prinzmetal's angina
Calcium channel blockers
15. Examples of alpha - glucosidase inhibitors (AGI)
Tetracycline
Acarbose - miglitol
Codeine - hydrocodone - and oxycodone
Opioid Analgesics
16. Cutaneous flush and be reduced by pretreatment with
Ascending pathways
Scopolamine - meclizine
Aspirin
Nausea
17. SE of acetazolamide
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Lorazepam - oxazepam - and temazepam
Desflurane
Long acting cholinesterase inhibitors
18. 2nd generation antihistamines
Mostly in the brain - and they mediate synaptic inhibition via increased K+ conductance
Mast cell stabilizer
Fexofenadine - loratadine - and cetirizine
Long acting cholinesterase inhibitors
19. Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage - cardiac arrhythmias - and myocardial infarction
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Cocaine
Buspirone
Sulfonamides
20. Agent effective in physiologic and essential tremor
Ethanol
Neuroleptanesthesia
Na+/K+ exchange
Propranolol
21. Patients being treated with lithium - who are dehydrated - or taking diuretics concurrently - could develop
Lithium toxicity
Nateglinide
Esmolol
Alkalinize urine - dialysis
22. H2 blocker that causes the most interactions with other drugs
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
Bioavailability (F)
Cimetidine
Acetazolamide
23. MOA of thiazolindinediones
Stimulate PPAR- gamma receptor to regulate CHO and lipid metabolism
Kidney and liver toxicity - diarrhea
Hydroxychloroquine
Cosyntropin
24. Side effects seen with tricyclic antidepressants
Dimercaprol
block SLUD (salivation - lacrimation - urination - defecation
Naloxone
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
25. SE of spironolactone
Thrombocytopenia
Ephedrine
Gynecomastia hyperkalemia - and impotence
Insulin glargine
26. Nonselective alpha - blocking drug - short acting and reversible - used for rebound HTN from rapid clonidine withdrawal - and Raynaud's phenomena
Phentolamine
Ultralente (humulin U)
Aldehyde dehydrogenase
Efficacy
27. Non - depolarizing skeletal muscle antagonist that has short duration
Mivacurium
Beta - blockers such as propranolol
Etidronate
Benzodiazepine receptor BZ1 (although do not have a benzodiazepine ring structure)
28. MOA for Ethosuximide
Cartilage damage
Methotrexate
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Calcium channels
29. Newer atypical antipsychotic used for bipolar disorder - known to cause weight gain - and adversely affect diabetes
Nevirapine - amprenavir
Olanzapine
Hallucinations resembling psychosis
Rheumatic disease
30. Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
Amrinone and milrinone
Heroin - morphine - oxycodone - meperidine and fentanyl
N- acetylcysteine
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)
31. Treatment of atropine overdose and glaucoma (because lipid soluable). Enters the CNS rapidly and has a stimulant effect - which may lead to convulsions
Hepatic enzymes
FOMEPIZOLE - used to prevent formation of toxic metabolites from methanol and ethylene glycol ingestion
Abciximab - tirofiban and eptifibatide
Physostigmine
32. DOC for febrile seizures
Aspirin
Specificity
Phenobarbital
Nifedipine
33. Anticancer drug also used in RA - produces acrolein in urine that leads to hemorrhagic cystitis
Cyclophosphamide
Tamsulosin
Selegiline
Tissue plasmin activator
34. Aspirin reduces mortality in unstable angina by
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Platelet aggregation inhibition
Cocaine
Lipoprotein lipase
35. Fibrates (gemfibrozil) increase activity of
Little C- peptide
Overdose of opioids
Lipoprotein lipase
DOM - STP - MDA - and MDMA 'ecstasy'
36. Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
Volume of distribution (VD)
Epinephrine
Insulin
Parathion
37. Cystitis - postoperative bladder spasms - or incontinence
Ketamine
Vancomycin
Vitamin K and Fresh frozen plasma (FFP)
Oxybutynin - dicyclomine
38. Treatments available for nicotine addiction
Alkylating agent
Haloperidol
Methadone
Patches - gum - nasal spray - psychotherapy - and bupropion
39. Anti - thyroid drugs
Tolerance
Pramipexole and ropinirole
Thioamides - iodides - radioactive iodine - and ipodate
Reducing progression of heart failure (never use in acute heart failure)
40. Cholinomimetics that increase outflow - open trabecular meshwork - and cause ciliary muscle contraction
Esmolol
Pilocarpine - carbachol - physostigmine
Spironolactone
Pancuronium
41. Agents that reduce heart rate - contractility - and O2 demand
Iron deiodinates thyroxine
Beta - blockers
Paresthesias - alkalization of the urine (which may ppt. Ca salts) - hypokalemia - acidosis - and encephalopathy in patients with hepatic impairment
Valproic acid and Phenytoin
42. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea
Heroin - morphine - oxycodone - meperidine and fentanyl
Zollinger - Ellison Syndrome
Timolol (nonselective) - betaxolol (selective)
SSRI's - bupropion - and venlafaxine
43. This beta blocker is highly lipid soluble and may account for side effects such as nightmares
Cevimeline
Agranulocytosis
Propranolol
Inhaled anesthetics - especially isoflurane - aminoglycosides - and antiarrhythmic
44. First generation sulfonylurea
Chlorpropamide - tolbutamide - tolazamide - etc.
Classic
Penicillamine
Arteries and veins
45. Drug that causes gray baby syndrome and aplastic anemia
Chlorpropamide - tolbutamide - tolazamide - etc.
Chloramphenicol
Estogens increase maternal TBG
Labetalol and carvedilol
46. Inhibitors of CYP450
Therapeutic index
Hypertensive crisis
Oral and transdermal forms of nitroglycerin
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
47. SE for ganciclovir
Neutro - leuko and thrombocytopenia
Low potency phenothiazines and ziprasidone
Aminocaproic acid
Buspirone
48. SE of tPA
Dantrolene
Nortriptyline - Desipramine
Cerebral hemorrhage
Probenecid and sulfinpyrazone
49. Chelating agent used in Wilson's disease
Older antipsychotics
Tinnitus - GI bleeding
Valproic acid
Penicillamine
50. Antidote used for organophosphate/anticholinesterase poisoning
Atropine - pralidoxime (2- PAM)
Nonselective Muscarinic Antagonists
Aminoglutethimide
Osteopenia - impaired wound healing - inc. risk of infection - inc. appetite - HTN - edema - PUD - euphoria - psychosis - stria - thinning of skin