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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Proteins that prevent action of tumor necrosis factor alpha (TNF- alpha)






2. Somatostatin (SRIF) analog used for acromegaly - carcinoid - glucagonoma and other GH producing pituitary tumors






3. The elimination of drug that occurs before it reaches the systemic circulation






4. Nitrate used for acute anginal attacks






5. Patients being treated with lithium - who are dehydrated - or taking diuretics concurrently - could develop






6. Maximum response achieveable from a drug






7. Skeletal muscle agent that can block muscarinic receptors






8. DOC for influenza A






9. Prostaglandin used in the treatment of impotence






10. Antiestrogen drugs used for fertility and breast cancer respectively






11. Common side effect of Rifampin






12. Receptors for serotonin (5HT-1) are located






13. Most useful in patients with significant anxiety - phobic features - hypochondriasis - and resistant depression






14. SE of heparin






15. Reason troglitazone was withdrawn from market






16. Drug of choice for leprosy






17. Digoxin toxicity can be precipitated by






18. SE of Aspirin






19. Leads to respiratory depression progressing to coma and death






20. Most common side effect of 1st generation antihistamines






21. MOA of class IV antiarrhythmics






22. Primary endogenous substrate for Nitric Oxidase Synthase






23. Dose which is lethal to 50% of the population






24. Moderate opioid agonists






25. Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea






26. Antidote used for acetaminophen (APAP) toxicity






27. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation






28. SE of ergot alkaloids






29. Inhibitors of catechol - O- methyltransferase (COMT) - used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)






30. Beta 2 agonist toxicity






31. Antidepressant associated with seizures and cardiotoxicity






32. SE of phenytoin






33. IV Drug used Hypertensive Crisis






34. Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol - oxidizing system (MEOS)






35. ACE inhibitors are contraindicated in






36. This beta blocker is the longest acting






37. Common SE of sulfonylureas - repaglinide - and nateglinide






38. Ability to bind reversibly to the same site as the drug and without activating the effector system






39. Concentration in the plasma times (clearance divided by bioavailability)






40. A hormone whose mechanism of action (MOA) utilizes intracellular receptors






41. Drugs decrease intestinal absorption of cholesterol






42. Dopamine agonist used in hyperprolactinemia






43. Anti - arrhythmics that decrease mortality






44. The fraction of administered dose of a drug that reaches systemic circulation






45. Produce mydriasis and cycloplegia






46. These LA's have surface activity






47. Osmotic diuretic used to treat increased intracranial pressure






48. Important in muscle and adipose tissue for glucose transport across muscles and TG storage by lipoprotein lipase activation






49. Secondary amines that have less sedation and more excitation effect






50. Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation