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Test your basic knowledge |
USMLE/COMLEX Step 1 Pharmacology One Liners
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
,
comlex
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents
Chlorpropamide - tolbutamide - tolazamide - etc.
Overdose of opioids
Celecoxib
Halothane and methoxyflurane
2. SE of demeclocycline
Bone marrow and teeth discoloration for children under 8 years of age
Oral and transdermal forms of nitroglycerin
Gingival hyperplasia
Abciximab - tirofiban and eptifibatide
3. Beta 1 agonists used in acute CHF
Interleukin 11 (oprelvekin)
Dobutamine and dopamine
Clindamycin
Aplastic anemia and renal toxicity
4. Concern using lithium
Low therapeutic index
Edrophonium
Thioamides - iodides - radioactive iodine - and ipodate
Acid reflux disease - duodenal ulcer and peptic ulcer disease
5. NSAID that is used for acute condition - such as pre - op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
Block voltage - dependent sodium channels
Amantadine
Ketoralac
Prednisone - methylprednisolone - prednisolone - and triamcinolone
6. Drug that causes gray baby syndrome and aplastic anemia
Dapsone - rifampin and clofazimine combination
Somatostatin
Chloramphenicol
Sodium channel blockers
7. DOC for CMV retinitis
Mifepristone
Ganciclovir
First generation due to being more lipid - soluble
Methadone - followed by slow dose reduction
8. TCA used in chronic pain - a hypnotic - and has marked antimuscarinic effects
Aminocaproic acid
Ethinyl estradiol and mestranol
Reducing preload
Amitriptyline
9. Carbamate with intermediate action - used for+A1170 postoperative and neurogenic ileus and urinary retention
Mifepristone (RU-486)
Hyperuricemia - hypokalemia and hyperglycemia
Neostigmine
Disulfiram - metronidazole - certain sulfonylureas and cephalosporins
10. Triptan available in parenteral and nasal formulation
Meperidine
Barbiturates - phenytoin - carbamazepine - and rifampin
Cimetidine
Sumatriptan
11. The most common neurologic abnormality in chronic alcoholics
Peripheral neuropathy (also excessive alcohol use is associated with HTN - anemia - and MI)
Aplastic anemia and renal toxicity
Amiodarone
Monamine oxidase inhibitors
12. Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property
Liver enzyme INDUCTION
Ephedrine
Amoxapine
Amphetamines
13. Opioid associated with respiratory depression - but is used in high risk patients who may not survive full general anesthetia
Carbamazepine - gabapentin - lamotrigine - and valproic acid
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Mast cell stabilizer
Fentanyl
14. Major SE of bisphosphonates
Amoxapine
Side - effect profile and prior pt response
Fluoxetine
Chemical esophagitis
15. Opioids used in anesthesia
Morphine and fentanyl
Raloxifene
prolongs QT and PR interval
Aminocaproic acid
16. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Cimetidine - ketoconazole - erythromycin - isoniazid and grapefruit
Amoxicillin
Leuprolide
17. Organophosphate anthelmintic agent with long DOA
Dantrolene
Potential for development of Reye's syndrome
Metrifonate
Thioridazine
18. Agents having active metabolites - long half lives - and a high incidence of adverse effects
Bleeding
Diazepam - Flurazepam - chlordiazepoxide - and clorazepate
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Diazepam
19. Non - steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
Halothane and methoxyflurane
Acetazolamide
Diethylstilbestrol (DES)
Cyproheptadine
20. Distribution of histamine receptors H1 - H2 - and H3
Asthma (bronchospastic effects) - diabetes (block signs of hypoglycemia) and peripheral vascular disease
Smooth muscle; stomach - heart - and mast cells; nerve endings - CNS respectively
Volume of distribution (VD)
CNS toxicity
21. 5HT-3 antagonist used in chemotherapeutic induced emesis
Odansetron - granisetron
Ondansetron - granisetron - dolasetron and alosetron
Carbamazepine
CNS depressants
22. Agent having no effect on D2 receptors - blocks D4 - reserved for resistant schizophrenia - and can cause fatal agranulocytosis
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Entacapone and Tolcapone
Clozapine
Adenosine
23. Drug that causes contraction of the uterus
Valproic acid
Zero order kinetics
Oxytocin
Zolpidem - zaleplon
24. SE of clonidine
Epinephrine
Naltrexone
AZT (zidovudine)
Rebound HTN - sedation - dry mouth
25. Extrapyramidal dysfunction is more common with these agents - Which block this subtype of dopamine receptor
Block cell wall synthesis by inhibiting peptidoglycan cross - linkage
Ganciclovir - zidovudine - saquinavir - and interferon
Nitroglycerin sublingual tablets
Older antipsychotic agents - D2 receptors
26. Period of time of therapy after which GC therapy will need to be tapered
Digibind
Reduce the loss from area of injection
Serotonin syndrome
5-7 days
27. Antidepressant associated with seizures and cardiotoxicity
Maprotiline
Physostigmine
Clozapine
Diphenhydramine and cimetridine - respectively
28. CCB are DOC for
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29. This step of metabolism makes a drug more hydrophilic and hence augments elimination
Phase I
Atropine - homatropine - C1208 tropicamide
Cocaine
Drug induced Parkinsonism
30. Treatment with cancer chemotherapy at high doses every 3-4 weeks - too toxic to be used continuously
Gynecomastia
Antithrombin 3
Pulse therapy
Act on intestine - delay digestion and absorption of glucose formed from digestion of starch and disacchrides
31. Prototype antagonist of H1 and H2 receptors
Diphenhydramine and cimetridine - respectively
Cardiac anomalies and is contraindicated in pregnancy or lactation
Nandrolone - oxymetholone - and oxandrolone
Aplastic anemia and renal toxicity
32. Metronidazole SE if given with alcohol
Disulfiram - like reaction
Methimazole and propylthiouracil (PTU)
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP
Desmopressin (DDAVP)
33. Antiprogestin used as potent antagonist of GC receptor
Diethylstilbestrol (DES)
Zolpidem - zaleplon
Mifepristone
Alkylating agent
34. Weak opioid agonist - poor analgesic - its overdose can cause severe toxicity including respiratory depression - circulatory collapse - pulmonary edema - and seizures
Valproic acid
Propoxyphene
Hepatic enzymes
Aspirin
35. Incidence of hyoglycemia with metformin
Bradykinin and histamine
None
Zafirlukast and montelukast
Naloxone
36. Toxicity of these agents include bradycardia - AV blockade - exacerbation of acute CHF; signs of hypoglycemia may be masked (tachycardia - tremor - and anxiety)
Tolerance
Beta blockers
Prolongs QT interval
Methotrexate
37. Anti - microbials that cause hemolysis in G6PD- deficient patients
Clomipramine - fluoxetine and fluvoxamine
Sulfonamides
Atenolol - acebutolol - and metoprolol
Indomethacin
38. NSAID also available as an ophthalmic preparation
Ganciclovir - zidovudine - saquinavir - and interferon
Atropine - pralidoxime (2- PAM)
Tetracycline
Diclofenac - ketoralac
39. Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure
Minocycline
Fexofenadine - loratadine - and cetirizine
Nefazodone
Aspirin - metoprolol
40. Prostaglandins that cause abortions
Nortriptyline - Desipramine
Prostaglandin E1 (misoprostol) PGE2 - and PGF2alpha
Sumatriptan
Calcium
41. Block glycoprotein IIb/IIIa involved in platelet cross - linking
Deferoxamine
Specificity
Abciximab - tirofiban and eptifibatide
Buspirone
42. Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage - cardiac arrhythmias - and myocardial infarction
Bromocriptine
Edrophonium
Cocaine
Serum ammonia and LFT's
43. Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy
Dextromethorphan - Codeine
Methicillin - nafcillin - and dicloxacillin
Efficacy
Interleukin 11 (oprelvekin)
44. Drugs that can be used for infantile spasms
Neuroleptanesthesia
Corticosteroids
Infants
Erythropoietin
45. Clinical response that may fluctuate in tx of Parkinson's dx
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46. Opioid antagonist that is given orally in alcohol dependency programs
Thioamides - iodides - radioactive iodine - and ipodate
Coma - Convulsions - Cardiac problems (arrhythmias and wide QRS)
Flumazenil
Naltrexone
47. All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction
Nephrotoxicity
Meperidine
Ketoconazole
Succinylcholine
48. Products of Phase II conjugation
ACE inhibitors
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Hypertrichosis
Glucuronate - acetic acid - and glutathione sulfate
49. When the rate of drug input equals the rate of drug elimination
Gingival hyperplasia - nystagmus - diplopia and ataxia
Ketanserin cyproheptadine - and phenoxybenzamine
Steady state
Sodium channel blockade
50. 5HT-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease
Spironolactone
Ticlopidine
Dolasetron
Nicotine