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USMLE/COMLEX Step 1 Pharmacology One Liners

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Anti - seizure agent that induces formation of liver drug - metabolism enzymes - is teratogen and can cause craniofacial anomalies and spina bifida






2. Drugs of choice for status epilepticus






3. Common toxicities of cisplatin






4. Hyperglycemic agent that increases cAMP and results in glycogenolysis - gluconeogenesis - reverses hypoglycemia - also used to reverse severe beta - blocker overdose and smooth muscle relaxation






5. Antidepressant associated with seizures and cardiotoxicity






6. Beta 2 agonist toxicity






7. Muscarinic antagonist used in asthma






8. This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias - alkalinization of the urine may precipitate calcium salts - hypokalemia - acidosis






9. Diuretics work in CHF by






10. GnRH antagonist with more immediate effects - used for infertility






11. Pneumonic for beta receptors






12. Interact with microtubules (but unlike vinca which prevent disassembly of tubules) - it stabilizes tubulin and cells remain frozen in metaphase






13. Antidote for arsenic - mercury - lead - and gold poisoning






14. H1 antagonist used in motion sickness






15. Neurotransmitters affected by the action of antidepressants






16. Site of action of loop diuretics






17. Beta 1 agonists used in acute CHF






18. Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia






19. Diuretic used for mountain sickness and glaucoma






20. Agents that inhibit acetaldehyde dehydrogenase






21. Ability of a drug to produce 100% of the maximum response regardless of the potency






22. Longer acting Beta 2 agonist is recommended for prophylaxis of asthma






23. Inhaled anesthetic - less likely to lower blood pressure than other agents - and has the smallest effect on respiration






24. Antidote used for tricyclic antidepressants (TCA)






25. Drug used in exoerythrocytic cycle of malaria






26. Window between therapeutic effect and toxic effect






27. 1st generation antihistamine that is least sedating






28. Cheap wide spectrum antibiotic DOC for otitis media






29. MOA of nitrates






30. 1st generation antihistamine that is highly sedating






31. Newer estrogen receptor antagonist used in advanced breast cancer






32. Rapid acting insulins that do not self - aggregate






33. Triptan available in parenteral and nasal formulation






34. Antivirals that are teratogens






35. Agent that is teratogen and causes a fetal syndrome






36. Intermediate acting glucocorticoids






37. HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism






38. Major drug interaction with Quinidine






39. Lithium is associated with this congenital defect






40. Inhibitor of MAO type B which metabolizes dopamine - used adjunct to levodopa or as sole agent in newly diagnosed patients






41. Anti - psychotic not shown to cause tardive dyskinesia






42. 2nd generation antihistamines






43. Antiarrhythmic that exhibits Class II and III properties






44. Side effects seen with tricyclic antidepressants






45. Block glycoprotein IIb/IIIa involved in platelet cross - linking






46. Similar to clonidine and may cause hypotension






47. Site of action for zaleplon and zolpidem






48. MOA of drug or foods (grapefruit juice) that increase statin effect






49. Reason ergot alkaloids are contraindicated in pregnancy






50. Almost all local anesthetics have this property and sometimes require the administration of vasoconstrictors (ex. Epinephrine) to prolong activity