Test your basic knowledge |

USMLE/COMLEX Step 1 Pharmacology One Liners

Subjects : health-sciences, usmle-step-1, comlex

Instructions:

Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can study here.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Anti - arrhythmic with 15 second duration of action
Amoxapine
Adenosine
Carbenicillin - piperacillin and ticarcillin
Hypertensive crisis

2. Atropine fever is the most dangerous effect and can be lethal in this population group
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Infants
Anterograde amnesia
Nifurtimox

3. COX 2 inhibitors should be used cautiously in pts with
Pre - existing cardiac or renal disease
Anti - inflammatory - analgesia - antipyretic and antiplatelet activity
Dimercaprol
Little C- peptide

4. Enhances dopaminergic neurotransmission SE's include CNS excitation - acute toxic psychosis and livedo reticularis
Clozapine
Rhabdomyolysis
GLUT 4
Amantadine

5. Indirect - Acting ACh Agonist - alcohol - short DOA and used in diagnosis of myasthenia gravis
Fomepizole
Edrophonium
Clearance (CL)
Competitive antagonist

6. Leads to respiratory depression progressing to coma and death
Overdose of opioids
Little C- peptide
Prazosin - terazosin and doxazosin (- AZOSIN ending)
Disulfiram

7. Carbonic anhydrase inhibitor
Methotrexate
Acetazolamide
increase the FREQUENCY of GABA- mediated chloride ion channel opening
Physostigmine

8. GnRH agonist used for infertility or different types of CA depending on pulsatile or steady usage respectively
Panic attacks - social phobias - bulimia nervosa - and PMDD (premenstrual dysphoric disorder) - OCD
Nondepolarizing type antagonists
Leuprolide
CNS toxicity

9. Endogenous substances commonly interpreted as histamine - serotonin - prostaglandins - and vasoactive peptides
Atrial fibrillation and CHF
Heroin - morphine - oxycodone - meperidine and fentanyl
Autocoids
Ethanol or fomepizole

10. Direct vasodilator of arteriolar smooth muscle
Neostigmine
sulfamethoxazole/ trimethoprim
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Hydralazine

11. H1 blocker that is also a serotonin antagonist
Cyproheptadine
Esmolol
Bleomycin
AZT (zidovudine)

12. Drug used for N. gonorrhea in females
Inhibit Cytochrome P450 3A4
Ceftriaxone
Yohimbine
NO - chloroform - and diethyl ether

13. T3 compound less widely used
Atropine
Cytomel
Carbamazepine
Salmeterol

14. Agent for pernicious anemia
Aminoglutethimide
Cyanocobalamin (Vit B12)
Adenosine
Maintenance dose (Cp*(CL/F))

15. Side effects seen with tricyclic antidepressants
Tamoxifen
Muscarinic blockade (dry mouth - constipation); weak alpha -1 block (orthostatic hypotension); weak hisamine block (sedation)
Suramin
Acetazolamide

16. MOA of lovastatin (STATIN)
Nitrous oxide
inhibits HMG COA reductase
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Constipation - edema - and headache

17. Peptide drug used to treat CHF
Nesiritide (BNP)
Pilocarpine
Flunitrazepam (rohypnol)
Pioglitazone - Rosiglitazone - Troglitazone (withdrawn/d from market)

18. Anticoagulant of choice in pregnancy
Potency
5-7 days
Heparin
Aspirin

19. Cephalosporins able to cross the BBB
Thioridazine
Rhabdomyolysis and Hepatotoxicity
Infants
Cefuroxime (2nd) generation - Ceftazidime - Ceftriaxone

20. These agents are congeners of Amphetamine

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

21. Anti - psychotic not shown to cause tardive dyskinesia
Xanthine oxidase
Clozapine
Insulin
Zileuton

22. Interaction with this drug requires dose reduction of 6- MP
Acute intermittent porphyria
Allopurinol
Hepatic enzymes
Hepatotoxicity

23. Median toxic dose required for a toxic effect in 50% of the population
Nifurtimox
Procarbazine
Hypoglycemia
TD50

24. Class of drugs whose MOA utilizes ligand gated ion channels
Nevirapine - amprenavir
Capsaicin
Norepinephrine and serotonin
Benzodiazepines and calcium channel blockers

25. Long acting beta 2 agonist used in asthma
Amphetamines
Scopolamine - meclizine
Salmeterol
Insulin release from pancreas by modifying K+ channels

26. SE of minoxidil
Hypertrichosis
Cisplatin
Fomepizole
Naloxone (IV) - naltrexone (PO)

27. Sulfonylurea Not recommended for elderly because of very long half life
Pindolol and acebutolol
Nonselective Muscarinic Antagonists
Flatulence (do not use beano to tx) - diarrhea - abdominal cramps
Chlorpropamide

28. Another pneumonic for anticholinergic toxicity

Warning: Invalid argument supplied for foreach() in /var/www/html/basicversity.com/show_quiz.php on line 183

29. MOA of nesiritide
Increasing sodium excretion and decreases arterial and venous tone
Dapsone - rifampin and clofazimine combination
Aplastic anemia and renal toxicity
Labetalol and carvedilol

30. Antidepressants with no effect on BP - no sedation
Valproic acid - carbamazepine - phenytoin and gabapentin
SSRIs
Buspirone
Prolongs QT interval

31. Antidote for digoxin toxicity
Adenosine
ORAL vancomycin
Digibind
Pilocarpine - carbachol - physostigmine

32. Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
Ipodate
Carbamazepine
Aminoglutethimide
SSRIs

33. Agents having higher sedation and antimuscarinic effects than other TCA's
Acetazolamide
Cortisone and hydrocortisone (equivalent to cortisol)
Tertiary amines
Sodium channel blockers

34. Readily detected markers that may assist in diagnosis of the cause of a drug overdose include
Prostaglandin PGF2a
Cholinesterase regenerators - pralidoxime
Changes in heart rate - blood pressure - respiration - body temperature - sweating - bowel signs - and pupillary responses
'dry as a bone - red as a beet - mad as a hatter - hot as a hare - blind as a bat'

35. Drug of choice for leprosy
Alprazolam and Clonazepam
Dapsone - rifampin and clofazimine combination
PTU
Sodium channel blockers

36. The fraction of administered dose of a drug that reaches systemic circulation
Gastric ulcers and GI Bleeding
Methotrexate
Inhibit DNA gyrase
Bioavailability (F)

37. DOC for status epilepticus
Dextroamphetamines and methamphetamine
Pralidoxime - atropine
Diazepam
Leuprolide

38. Intermediate acting glucocorticoids
Labetalol and carvedilol
ACE inhibitors
Prednisone - methylprednisolone - prednisolone - and triamcinolone
Inhibits phosphodiesterase -5 - enhancing effects of nitric oxide - activated increases in cGMP

39. Agent used for closure of patent ductus arteriosus
Didanosine
Testosterone
Propofol
Indomethacin

40. Increase bone density - also being tested for breast CA prophylaxis
Esmolol
Protamine
Raloxifene (SERM- selective estrogen receptor modulator)
Sinus tachycardia and serious arrhythmias

41. Analog of hypoxanthine - needs HGPRTase for activation
6- mercaptopurine (6- MP)
inhibits HMG COA reductase
Ortho - Evra
Letrozole - anastrozole

42. For rebound HTN from rapid clonidine withdrawal
NSAIDS
Heparin induced thrombocytopenia (HIT)
Phentolamine
Toremifene (Fareston)

43. Used for Addison's disease - Congenital Adrenal Hyperplasia (CAH) - inflammation - allergies - and asthma (as a local inhalation)
Use in IgE mediated allergic reaction
Mast cell stabilizer
Aspirin
Glucocorticoids

44. Mechanisms of action for Phenytoin - Carbamazepine - Lamotrigine
Clopidogrel and ticlopidine
Xanthine oxidase
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Sodium channel blockade

45. ABVD regimen used for HD - but appears less likely to cause sterility and secondary malignancies than MOPP
Adriamycin (doxorubicin) +bleomycin - vinblastine +dacarbazine
Propranolol
Naltrexone
Full agonist

46. Drugs decrease intestinal absorption of cholesterol
TD50
Theophylline
Bile acid - binding resins
Dimenhydrinate - meclizine - and other 1st generation

47. Anti - seizure drugs used also for bipolar affective disorder (BAD)
Valproic acid - carbamazepine - phenytoin and gabapentin
Desmopressin (DDAVP)
Pregnancy
Orthostatic hypotension (especially with first dose) and reflex tachycardia

48. Inhaled anesthetics are myocardial depressants
Enflurane and halothane
Esmolol
Angiotensin receptor
Block voltage - dependent sodium channels

49. GHRH analog used as diagnostic agent
Sermorelin
Psychotic state - overdose causes agitation - restlessness - tachycardia - hyperthermia - hyperreflexia - and seizures
Bradycardia - SEXUAL DYSFUNCTION - decrease in HDL - and increase in Triglycerols (TG)
Meperidine

50. MOA of general anesthetics
Most are thought to act at GABA- A receptor - chloride channel
Diazepam
Octreotide
Lispro (Humalog) - aspart - glulisine