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USMLE Embryo
Start Test
Study First
Subjects
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health-sciences
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usmle
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is omphalocele? In What trisomies is it seen?
Transposition of great vessels (failure to spiral)- right to left shunt; tetralogy of Fallout (right to left shunt caused by skewed development of septum); persistent TA (partial septum development - also right to left shunt)
not covered
Persistance of herniation of abdominal contents into umbilical cord covered by peritoneum; 13 - 18
Cerebellar tonsillar herniation through foramen magnum
2. From which germlayer does the thyroid develop?? From what structure exactly?
Valproate acid
Pharynx to duodenum; duodenum to transverse colon; distal transverse colon to rectum
Endoderm - floor of primitive pharynx
Temporary cervical sinus
3. From What embryonic layer does the skin dermis arise?
Mesoderm
Ectoderm
Base of limbs in the zone of polarizing activity; ant - post
Gastric outlet obstruction (bilious vomiting - feeding intolerance - abdominal distention)
4. What teratogens can cause CN VIII toxicity in the fetus?
Endoderm
Mesoderm
All or none
Aminoglycosides
5. With the first breath the infant take - pulmonary vasculature resistance _______ which causes an increase in left atrial pressure
Persistent connection between amniotic cavity and spinal canal; low folic acid
Decreases
4th/5th branchial pouches
Surface ectoderm
6. What embryonic structure gives rise to the ascending aorta? what else does it give rise to?
5th
Truncus arteriosus; pulmonary trunk
Hepatic circulation; ligamentum venosum
Congenital and chromosomal abnormalities
7. From What embryonic layer do the parafollicular cells of the thyroid arise?
Ectoderm
Neural crest cells
Failure of the urachus to obliterate; outpouching of the bladder
Tunica vaginalis not fully fused
8. What is an arnold chiari II malformation? through what hole does it herniate?
Cerebellar tonsillar herniation through foramen magnum
Dorsal; sensory
Congenital and chromosomal abnormalities
Decidual basalis
9. From where do the three different kidneys come from? Which is the earliest one? is it located most cranially or caudally?
During; instrinsic
Persistent connection between amniotic cavity and spinal canal; low folic acid
Pronephros - mesonephros - metanephros; pronephros; most cranially
Surface ectoderm
10. Which CN allows for taste and sensation in the posterior 1/3 of the tongue? how about the very back ?
IX; X
Physiologic incomplete muscular ventricular septum
Duodenum to transverse colon; distal transverse colon to rectum
Foregut; dorsal mesentery (mesodermal)
11. what bone/cartilage and nerves are derived from branchial arch 3?
OCPS and maternal diabetes
A vitelline fistula - failure of vitelline duct to close
Greater horn of hyoid; CN IX (styloPharyngeus)
4th pouch
12. what results if they dont? What can increase the risks of this?
Tongue
Week 3-8
Mid gut to yolk sac; omphalomesenteric duct; 7th week
Persistent connection between amniotic cavity and spinal canal; low folic acid
13. What teratogen can cause IUGR and ADHD in a fetus? what else can this teratogen cause?
Nicotine; preterm labor
Decreases
Ectoderm - mesoderm - endoderm; epiblast - primitive streak - hypoblast; week 3
4th arch; 6th arch
14. What is holoprosencephaly? what eye disorder does it result in?
Decreased separation of hemispheres across midline; cyclopia
Surface ectoderm
Failure of bony spinal canal to fuse; no; lower vertebral levels
Neural crest cells
15. What role does the placenta have?
DiGeorge
primary palate
3 -4 -6
Nutrient and gas exchange
16. which teratogen can cause Ebsteins anomaly in the fetus?
5th
Ovarian ligament and round ligament of uterus; anchors testes within scrotum
Ectoderm
Lithium
17. From What embryonic layer does bone of the skulls arise?
Neural crest cells
They are the edge of neural plate folding; all over the body
Prosencephalon - mesencephalon - rhombencephalon
Fetal kidney; fetal swallows - absorbs - and then removed from placental blood
18. What does the mullerian duct develop into? wollffian?
Fallopian tube - uterus - upper 1/3 of vagina
...
Decreased separation of hemispheres across midline; cyclopia
Grooves/clefts; arches; pouches
19. What type of radiation is teratogenic ?
Endoderm - floor of primitive pharynx
Ionizing
External auditory meatus
20-50yrs - Abdominal pain - Postprandial fullness - Nausea - Peptic ulcers - Pancreatitis - Rarely - biliary obstruction
20. In order to survive tricuspid atresia - What do you need?
VSD
Indomethacin; blocks PG production
Week 8
V3; VII
21. What causes persistent Truncus Arteriosus? What does it result in?
Prostaglandins
Week 8
They are the edge of neural plate folding; all over the body
Partial AP septum development; one large vessel leaves the heart - Right to left shunt
22. what separates the atria from the ventricles?
Endocardial cushions
Ventral and dorsal parts fail to fuse at 8th week; 2 pancreatic ducts!- more prone to pancreatitis
Occiptal
IX; X
23. From where is the pancreas derived? the spleen?
Neural crest cells
Foregut; dorsal mesentery (mesodermal)
When left to right shunting switching to right to left shunting
After; extrinsic
24. what muscles are derived from branchial arch 3?
Day 6; maintains corpus luteum; 1st trimester
StyloPharyngeus
Thyroglossal duct cysts will move with swallowing while persistent cervical sinuses in lateral neck wont
Decreases
25. What axis does the basal plate form? what neural system does it become?
Sperm plus egg
arnold chiari associated with thoraclumbar myelomeningocele
Ventral ; motor
Neuroectoderm
26. From What embryonic layer are the serous linings of the body cavities from? for ex - peritoneum?
Neural crest migration - they then cause spiral
Aberrant development of 3rd and 4th pouches; t cell def (thymic aplasia) - hypocalcemia (failure of parathyroid development) - CF and CV defects
Fetal and maternal
...
27. what bone/cartilage are derived from branchial arch 4-6?
Thyroid - cricoid - arytenoids - corniculate cuneiform
Week 8
Caused by compression on trocheal nerve - causes vertical gaze paralysis (associated with arnold chiari)
Surface ectoderm
28. What are the three regions of the brain (in order of cranial to caudal)?
Prosencephalon - mesencephalon - rhombencephalon
Ring of pancreatic tissue can cause duodenal narrowing; ventral pancreatic bud abnormally encircles 2nd part of duodenum
Meckels cartilage: mandible - malleus - INCUS - sphenoMandibular ligament; CN V2 and V3
Stapedius and hyoid artery
29. What is the initial step to interventricular septum development? is it complete?
Pharynx to duodenum; duodenum to transverse colon; distal transverse colon to rectum
Muscular ventricular septum; no
Surface ectoderm
V3; VII
30. Where is the most common ectopic thyroid tissue?
Neural crest cells
Tongue
Ectoderm
Bone/cartilage and nerves
31. What is congenital pharyngocutaneous fistula? and How does it occur?
Persistence of 3rd cleft (groove) and pouch causes fistula between tonsillar area and cleft in lateral neck
not covered
All or none
Thickened ectoderm at end of each developing limb
32. What are the two walls of the prosencephalon and What do they become?
Where the epiblast and hypoblast fuse
Endoderm
Vascular accident intra uterine; apple peel atresia
Cerebral hemisphere - thalami
33. what week do the genitalia start to have male/female characteristics? What trimester is that?
DES
Failure to recanalize; 21
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
Week 10-12; end of 1st trimester
34. Where is erythropoeisis in the weeks 3-8 of fetal development? Where does it occur after that? until when?
Yolk sac; liver (weeks 6-30) and spleen (9-28 weeks)
Embryonic period; 1st trimester
3rd and 4th arches
Pulm art (prox) and ductus arteriosus
35. What hormone is hcG structurally similar too?
Mesoderm
LH
OCPS and maternal diabetes
...
36. What axis is Wnt 7 responsible for developing?
Surface ectoderm
...
Failure of the urachus to obliterate; outpouching of the bladder
Dorsal ventral axis
37. What is the kidney that functions at the interim kidney in the 1st trimester? What does it later contribute to?
4th week
Thyroid - cricoid - arytenoids - corniculate cuneiform
Mesonephros; male genital system
Endometrium
38. Where is the FGF gene produced? What is it responsible for - How does it do this?
Prosencephalon
Aberrant development of 3rd and 4th pouches; t cell def (thymic aplasia) - hypocalcemia (failure of parathyroid development) - CF and CV defects
Ectoderm
Apical ectodermal ridge; limb lengthening; stimulates mitosis of underlying mesoderm
39. From where does the medulla form?
Reicherts cartilage: Stapes - Styloid process - Lesser horn of hyloid - Stylohyoid ligament and CN VII
Myelencephalon
Fetal alcohol syndrome; mental retardation
Respiratory distress syndrome
40. What artery is derived branchial (aortic) arch 1?
Alkylating agents
Thickened ectoderm at end of each developing limb
Maxillary
Dorsal and ventral buds
41. What is the notochord? What does the notochord later become?
Mesoderm; nucleous pulposos
Muscular ventricular septum; no
Foramen cecum and terminal sulus
Fluid filled syrinx causes expansion and degeneration of cord tracts
42. Other than not having a brain - what else is a symptom of anencephaly? why? hint: think about amniotic fluid
Branchial arch 2
Polyhydramnios
Ventral and dorsal parts fail to fuse at 8th week; 2 pancreatic ducts!- more prone to pancreatitis
Neural crest cells
43. Which branchial apparatus derivative makes the tympanic membrane of the ear?
Mesoderm; epiblast
Membrane - all 3 from 1st appartus
Ebsteins anomaly; tricuspid atresia
Mesoderm
44. What does the vitelline duct connect? What is it also known as? when should it obliterate?
Fluid filled syrinx causes expansion and degeneration of cord tracts
Surface ectoderm
Mid gut to yolk sac; omphalomesenteric duct; 7th week
Hypospadias
45. What part of the gut rotates around the SMA? and At what point?
Day 6; with implantation
Midgut; 10th week
Rhombencephalon
Cerebellar tonsillar herniation through foramen magnum
46. Which cranial nerve innervates the motor function of the tongue?
Lithium
3
XII
hypertrophy
47. From What embryonic layer does the gut tube epithelium arise?
Ventral shaft of penis (penile urethra); labia minora
Week 10-12; end of 1st trimester
Surface ectoderm
Endoderm
48. Which arches form the posterior 1/3 of the tongue?
Failure of the urachus to obliterate; outpouching of the bladder
Arches 3 and 4
Cleft lip/palate
StyloPharyngeus
49. Where is the apical ectodermal ridge?
1st
secondary palate
Mesoderm
Thickened ectoderm at end of each developing limb
50. What type of blood do umbilical veins carry? From where to where?
hypertrophy
Oxygenated; placenta to fetus (IVC)
Myelencephalon
Mental retardation - holoprosencephaly - facial features - fistulas
Can you answer 50 questions in 15 minutes?
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