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USMLE Embryo
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Study First
Subjects
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health-sciences
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usmle
Instructions:
Answer 50 questions in 15 minutes.
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study here
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. From What embryonic layer does the thyroid follicular cells arise?
Endoderm
Cleft lip/palate
Surface ectoderm
Mullerian inhibitory factor from Sertoli cells; increased androgen from Leydig cells
2. Where is the apical ectodermal ridge?
can make cells
SRY gene on Y chromosomes; sertoli and leydi; MIF and androgens; suppression of paramesonephric ducts and dev. of mesonephric (all respectively)
Week 8
Thickened ectoderm at end of each developing limb
3. During what week do the limbs begin to form?
Bilateral loss of pain and temperature sensation in upper extremities with preservation of touch sensation
Week 4
Muscles and arteries
Thalidomide; nausea
4. Where is sonic hedgehog gene produced? What axis is it responsible in patterning?
Endoderm
LH
Mesoderm; epiblast
Base of limbs in the zone of polarizing activity; ant - post
5. What hormones are in charge of external genitalia development in the fetus? (in both male and female)
Failure to spiral (aorta coming out of RV and PA coming out of left ventricle)- two completely separate systems
2nd pouch
DHT; estrogen
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
6. From where does the ureteric bud arise? What does it give rise to?
V3; VII
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
Fetal and maternal
The caudal end mesonephros; the ureter - pelvis - calyces - collecting ducts
7. What is the physiological herniation that occurs at the 6th week - what herniates out of the umbilical ring? when it comes back in the 10th week - What does it rotate around?
Umbilical - midgut herniates through umbilical ring; SMA
Branchial arch 2
Tongue
Transposition of great vessels (failure to spiral)- right to left shunt; tetralogy of Fallout (right to left shunt caused by skewed development of septum); persistent TA (partial septum development - also right to left shunt)
8. When does organogenesis occur?
Maxillary
Folate antagonists
Neuroectoderm
Week 3-8
9. What embryological structure gives rise to the trabeculated parts of the left and right ventricle?
Branchial arch 2
Week 4
Primitive ventricle
Pronephros - mesonephros - metanephros; pronephros; most cranially
10. What do the arches of the branchial apparatus correlate to?
Meckels cartilage: mandible - malleus - INCUS - sphenoMandibular ligament; CN V2 and V3
Mesdoerm
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
Week 3-8
11. From where is the allantois formed? During what week?
Neuroectoderm
Week 2; bilaminar disk; epiblast and hypoblast
Yolk sac; 3rd week
Neural crest cells
12. Where is the mothers blood located in the placenta?
blood entering the RA
Lacunae in between the chorionic villi
Mesdoerm
Neuroectoderm
13. From What embryonic layer does the spinal cord arise?
Neuroectoderm
Mental retardation - holoprosencephaly - facial features - fistulas
DiGeorge
Week 10-12; end of 1st trimester
14. From What embryonic layer do the ANS arise?
primary palate
Neural crest cells
Tetracyclines
Lithium; valve leaflets attach to domain down low in RV- 'atrialized RV'
15. What is a teratogen that causes Ebsteins anomaly? What is ebsteins anomaly?
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16. What is contained in the umbilical cord?
Neuroectoderm
Umbilical artery - vein; and whartons jelly (mucus connective tissue) - urachus
Neuroectoderm
Surface ectoderm
17. What embryological structures give rise to the SVC?
SRY gene on Y chromosomes; sertoli and leydi; MIF and androgens; suppression of paramesonephric ducts and dev. of mesonephric (all respectively)
Right common cardinal vein and right anterior cardinal vein
Stapedius and hyoid artery
3rd pouch
18. What part of the gut rotates around the SMA? and At what point?
Mesoderm
Lots - cleft palate/lip
Bones - cartilage - and nerves
Midgut; 10th week
19. What axis is Wnt 7 responsible for developing?
Yolk sac; liver (weeks 6-30) and spleen (9-28 weeks)
Dorsal; sensory
Dorsal ventral axis
septum primum and/or secundum
20. When does hcG get secreted? What does it do?up until when ?
Arnold Chiari and Dandy Walker; Arnold Chiari; Dandy Walker; Arnold Chiari
Polyhydramnios
Day 6; maintains corpus luteum; 1st trimester
Deoxygenated blood; fetal internal iliac arteries to placenta
21. When does the notochord form? and When does the neural plate form?
From endocardial cushions (ventral and dorsal meet each other)
Muscles and arteries
Mesoderm; 3 week
Duodenum to transverse colon; distal transverse colon to rectum
22. From where to Where is the foregut derivative? midgut? hindgut?
Pharynx to duodenum; duodenum to transverse colon; distal transverse colon to rectum
is no longer intact
secondary palate
Dorsal ventral axis
23. Where does fertilization occur?
Meckels cartilage: mandible - malleus - INCUS - sphenoMandibular ligament; CN V2 and V3
Ampulla
20-50yrs - Abdominal pain - Postprandial fullness - Nausea - Peptic ulcers - Pancreatitis - Rarely - biliary obstruction
Common carotid and internal carotid
24. From what region of the brain does the aqueduct form?
Bones - cartilage - and nerves
Hemorrhage - bone deformities
Week 4
Rhombencephalon
25. What teratogens can cause discolored teeth?
VSD
Tetracyclines
Endoderm
Week 3-8
26. Cleft lip is a failure of fusion of ________ and ______.
6-30
Maxillary and medial nasal processes
Mesonephros; male genital system
Grooves/clefts; arches; pouches
27. what results if they dont? What can increase the risks of this?
Bones - cartilage - and nerves
Neural crest cells
Mesoderm
Persistent connection between amniotic cavity and spinal canal; low folic acid
28. What are the two types of posterior fossa malformations? which one results in a hindbrain crowding? and which results in an enlarged posterior fossa? which one is associated with syringomelia?
DiGeorge
Mesoderm
Ventral shaft of penis (penile urethra); labia minora
Arnold Chiari and Dandy Walker; Arnold Chiari; Dandy Walker; Arnold Chiari
29. What is the female remnant of the gubernaculum? male remnant?
Uretopelvis; most common site for obstruction (hydronephrosis) in fetus
Week 4
Ovarian ligament and round ligament of uterus; anchors testes within scrotum
hypospadias
30. What role does the placenta have?
Cerebral hemisphere - thalami
DHT; estrogen
Metanephric mesenchyme; differentiation and formation of glomerulus and renal tubules to distal convoluted tubule
Nutrient and gas exchange
31. What components do the neural crest cells of the branchial arches give rise to?
Incomplete; yes
Day 6; maintains corpus luteum; 1st trimester
Bones - cartilage - and nerves
Dorsal and ventral buds
32. Where is the most common ectopic thyroid tissue?
Tongue
Endometrium
Neural crest development; MEN 2A (pheo - PTH tumor - parafollicular cell tumor)
Obliterated
33. What does the ureteric bud interact with and What does it induce it to become?
Week 8
Dorsal; sensory
4th pouch
Metanephric mesenchyme; differentiation and formation of glomerulus and renal tubules to distal convoluted tubule
34. What type of blood do umbilical veins carry? From where to where?
Obliterated; forms tunica vaginalis
Oxygenated; placenta to fetus (IVC)
Neuroectoderm
Partial AP septum development; one large vessel leaves the heart - Right to left shunt
35. failure to close of what fold results in sternal defects? omphalocele? gastrochisis? bladder extrosphy?
Rostral fold closure ; lateral fold closure; lateral fold closure; caudal fold closure
Duodenum to transverse colon; distal transverse colon to rectum
Spinothalamic first
Upper 1/3; urogenital sinus
36. Pyloric stenosis is characterized by _____________ of muscularis externis in the sphincter
1st cleft/groove (Ectoderm)
hypertrophy
Lithium; valve leaflets attach to domain down low in RV- 'atrialized RV'
6th aortic arch
37. What are the two components of the placenta? From What do they form? which one secreted hcG?
Mesoderm
primary palate
...
Apical ectodermal ridge
38. What is hypoplasia? is primordial tissue present?
Sperm plus egg
Incomplete; yes
DiGeorge
Myelencephalon
39. What is the kidney that functions at the interim kidney in the 1st trimester? What does it later contribute to?
Mesonephros; male genital system
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
3 -4 -6
Prenatal and perinatal
40. From What embryonic layer do CNS neurons arise?
Neuroectoderm
Endocardial cushions
All intrinsic muscles of larynx except cricothyroid; CN X (recurrent laryngeal nerve - speaking)
Surface ectoderm
41. What is used to keep the PDA open?
Uretopelvis; most common site for obstruction (hydronephrosis) in fetus
Spinothalamic first
Prostaglandins
Cerebral hemisphere - thalami
42. What axis does the alar plate form? what neural system does it become?
Dorsal; sensory
Endoderm - floor of primitive pharynx
Lithium
Pataus; fetal alcohol syndrome
43. From What embryonic layer is the eustachian tube from?
Mesoderm
DHT; estrogen
Indomethacin; blocks PG production
IX; X
44. By what week is there fetal movement?
Persistent connection between amniotic cavity and spinal canal; low folic acid
Week 8
Midgut; 10th week
Failure of bony spinal canal to fuse; no; lower vertebral levels
45. What causes the degeneration of the spinal cord in syringomelia?
Mesoderm
Fluid filled syrinx causes expansion and degeneration of cord tracts
Occiptal
Week 8
46. From where does pons form from? what else forms from there?
Mesoderm
Blind upper esophagus with lower esophagus connected to trachea; cyanosis - choking and vomiting with feeding; air bubble on CXR; polyhydramnios; failure to pass NG tube; pneumonitis
Aberrant development of 3rd and 4th pouches; t cell def (thymic aplasia) - hypocalcemia (failure of parathyroid development) - CF and CV defects
Metencephalon; cerebellum
47. Cleft lip is a failure of formation of the...
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
Thyroglossal duct cysts will move with swallowing while persistent cervical sinuses in lateral neck wont
primary palate
secondary palate
48. From what region of the brain does the fourth ventricle form?
Rhombencephalon
Sperm plus egg
Surface ectoderm
StyloPharyngeus
49. From What embryonic layer does bone arise ?
Cytotrophoblast
Pulm art (prox) and ductus arteriosus
Mesoderm
Endoderm
50. From What embryonic layer do the parafollicular cells of the thyroid arise?
Amniotic epithelium
Neural crest cells
Surface ectoderm
Mullerian inhibitory factor from Sertoli cells; increased androgen from Leydig cells
Sorry!:) No result found.
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