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Test your basic knowledge |
USMLE Embryo
Start Test
Study First
Subjects
:
health-sciences
,
usmle
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. When does the notochord form? and When does the neural plate form?
Found in lateral neck; from no obliteration of 2-4th clefts
Mesoderm; 3 week
Mesoderm
Stapedius and hyoid artery
2. What can vit A in excess cause in the fetus?
Pataus; fetal alcohol syndrome
Ventral ; motor
Lots - cleft palate/lip
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
3. From what does bicornuate uterus arise? What is it associated with?
Incomplete fusion of paramesonephric ducts; UT abnormalities and infertility
Metencephalon; cerebellum
elevated AFP
Neural crest migration - they then cause spiral
4. what else is the caudal regression known as? What two teratogen can cause this in the fetus?
4th pouch
4th arch; 6th arch
VACTERL; OCPs and maternal diabetes
LH
5. Which part of the chorionic villi can make cells?
Week 3-8
Ectoderm
Cytotrophoblast
Neural crest development; MEN 2A (pheo - PTH tumor - parafollicular cell tumor)
6. From What embryonic layer does the parathyroid arise ?
Endoderm
can make cells
Increase in oxygen concentration which decreases prostaglandin concentration
Decreased separation of hemispheres across midline; cyclopia
7. What does DHT turn the genital tubercle into? estrogen?
Decreases
Glans penis and corpus cavernosum and spongiosum; glans clitoris and vestibular bulbs
Muscles of Mastication: Temporalis - masseter - Lateral and Medila pterygoids - Mylohyoid - anterior belly of the digastric - tensor tympani - tensor veli palatini; ant 2/3 of tongue
Polyhydramnios
8. From what aortic arch does the common carotid artery arise? what else arises from this arch?
Decreases
Surface ectoderm
3rd; proximal part of the internal carotid artery
DiGeorge
9. Where is the FGF gene produced? What is it responsible for - How does it do this?
Allantois
Apical ectodermal ridge; limb lengthening; stimulates mitosis of underlying mesoderm
Foramen cecum and terminal sulus
Alkylating agents
10. What are the clinical symptoms that present with syringomelia?
6-30
Bilateral loss of pain and temperature sensation in upper extremities with preservation of touch sensation
Hypospadias
Failure of bony spinal canal to fuse; no; lower vertebral levels
11. What is the 'fetal period'- ie When is it?
Yolk sac; 3rd week
Failure of the urachus to obliterate
Meckels cartilage: mandible - malleus - INCUS - sphenoMandibular ligament; CN V2 and V3
Week 8
12. What is contained in the umbilical cord?
Umbilical artery - vein; and whartons jelly (mucus connective tissue) - urachus
Greater horn of hyoid; CN IX (styloPharyngeus)
From endocardial cushions (ventral and dorsal meet each other)
During; instrinsic
13. What is holoprosencephaly? what eye disorder does it result in?
Decreased separation of hemispheres across midline; cyclopia
Surface ectoderm
Nutrient and gas exchange
Surface ectoderm
14. What teratogens can cause CN VIII toxicity in the fetus?
Palpable olive mass in epigastric region; nonbilious projectile vomitting @around 2 weeks
Nutrient and gas exchange
Lithium; valve leaflets attach to domain down low in RV- 'atrialized RV'
Aminoglycosides
15. From What embryonic layer are the schwann cells from ?
Neural crest cells
Maternally derived; meconium
pyloric stenosis
Umbilical artery - vein; and whartons jelly (mucus connective tissue) - urachus
16. From where does the ureteric bud arise? What does it give rise to?
Mid gut to yolk sac; omphalomesenteric duct; 7th week
The caudal end mesonephros; the ureter - pelvis - calyces - collecting ducts
Medial palatine processes
Muscles of Mastication: Temporalis - masseter - Lateral and Medila pterygoids - Mylohyoid - anterior belly of the digastric - tensor tympani - tensor veli palatini; ant 2/3 of tongue
17. What trisomy is associated with holoprosencephaly? What teratogen?
Pataus; fetal alcohol syndrome
From endocardial cushions (ventral and dorsal meet each other)
2nd pouch
...
18. Which branchial derivative accounts for the sensation and taste in the posterior 2/3 of the tongue? how about the very back?
Hypertrophy of muscularis externis of pylorus; surgical incision
OCPS and maternal diabetes
Mesoderm
4th arch; 6th arch
19. WithIn what week does gastrulation occur? What is gastrulation?
Day 6; with implantation
Week 3; primitive streak formation from the epiblast makes the three layers
Physiologic incomplete muscular ventricular septum
Dorsal; sensory
20. What causes the degeneration of the spinal cord in syringomelia?
Hemorrhage - bone deformities
Mental retardation - holoprosencephaly - facial features - fistulas
Surface ectoderm
Fluid filled syrinx causes expansion and degeneration of cord tracts
21. what happens in hydrocele?
Neuroectoderm
Incomplete fusion of paramesonephric ducts; UT abnormalities and infertility
8
Tunica vaginalis not fully fused
22. The spleen is ____________ in origin and supplied by a foregut artery
Bilateral loss of pain and temperature sensation in upper extremities with preservation of touch sensation
mesodermal
Persistent connection between amniotic cavity and spinal canal; low folic acid
OCPS and maternal diabetes
23. From where does the medulla form?
Endoderm
blood entering the RA
Apical ectodermal ridge
Myelencephalon
24. What embryological structures give rise to the SVC?
Incomplete; yes
Dorsal; faulty positioning of genital tubercle
Dorsal and ventral buds
Right common cardinal vein and right anterior cardinal vein
25. What is meckel's diverticulum? What is it associated with? What does that cause?
Bulbourethral glands (of Cowper) and Prostate gland; greater vestibular glands (of Bartholin) and Urethral and paraurethral glands (of Skene)
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
Partial AP septum development; one large vessel leaves the heart - Right to left shunt
4th/5th branchial pouches
26. What teratogen can cause IUGR and ADHD in a fetus? what else can this teratogen cause?
Nicotine; preterm labor
...
Week 8
Diencephalon
27. What connects the thyroid to the tongue? when happens if it doesnt obliterate?
Thyroglossal duct; persists as pyramidal lobe of thyroid; foramen cecum on tongue is normal remnant of thyroglossal duct
Surface ectoderm
Yolk sac; 3rd week
Ampulla
28. What embryological structure gives rise to the coronary sinus?
Left horn of the sinus venosus
Hemorrhage - bone deformities
Mullerian inhibitory factor from Sertoli cells; increased androgen from Leydig cells
Hypertrophy of muscularis externis of pylorus; surgical incision
29. What causes meconium discharge from the umbilicus?
A vitelline fistula - failure of vitelline duct to close
Urogenital sinus; wolffian duct; mullerian duct; urogenital sinus; wolffian duct; wolffian duct; mullerian; mullerian
Vascular accident intra uterine; apple peel atresia
Prevent recurrent UTIs
30. From where does the pulmonary arteries and the ductus arteriosus arise?
6th aortic arch
Branchial arch 2
Neural crest cells
blood entering the RA
31. What is an arnold chiari II malformation? through what hole does it herniate?
Scrotum; labia majora
4th pouch
Cerebellar tonsillar herniation through foramen magnum
Nicotine; preterm labor
32. What is an example of a syndrome that can cause abnormal neural crest migration and thus CV abnormalities?
Lithium
DiGeorge
Bones - cartilage - and nerves
Neural crest cells
33. What is the leading cause of birth defects in the US? what else is this perpetrator the leading cause of?
can make cells
3rd; proximal part of the internal carotid artery
When the AP septum meets and fuses with the muscular ventricular septum to form membranous intraventricular septum - closing interventricular foramen
Fetal alcohol syndrome; mental retardation
34. What hormone is hcG structurally similar too?
LH
Endoderm
Synctiotrophoblast
Diencephalon
35. From What embryonic layer does the neurohypophysis arise?
Cerebral hemisphere - thalami
VACTERL- vertebral defect - anal atresia - cardiac defects - tracheo - esophageal fistula - renal defects - limb defects
Primitive ventricle
Neuroectoderm
36. What are the neural crest cells and where do they come form? where do they go?
Hemorrhage - bone deformities
They are the edge of neural plate folding; all over the body
Mesdoerm
Medial palatine processes
37. What is congenital pharyngocutaneous fistula? and How does it occur?
Foramen cecum and terminal sulus
Cleft lip/palate
Dorsal ventral axis
Persistence of 3rd cleft (groove) and pouch causes fistula between tonsillar area and cleft in lateral neck
38. What is omphalocele? In What trisomies is it seen?
Ionizing
Polyhydramnios
6th aortic arch
Persistance of herniation of abdominal contents into umbilical cord covered by peritoneum; 13 - 18
39. What does the vitelline duct connect? What is it also known as? when should it obliterate?
Neural crest cells
Mid gut to yolk sac; omphalomesenteric duct; 7th week
Neuroectoderm
Hemorrhage - bone deformities
40. Pyloric stenosis is characterized by _____________ of muscularis externis in the sphincter
Prosencephalon - mesencephalon - rhombencephalon
Neural crest cells
During; instrinsic
hypertrophy
41. What does the ductus venosus shunt blood away from? What is its remnant?
Scrotum; labia majora
Yolk sac; 3rd week
Neural crest cells
Hepatic circulation; ligamentum venosum
42. What artery is derived branchial (aortic) arch 2?
Obliterated; forms tunica vaginalis
Neuroectoderm
Oxygenated; placenta to fetus (IVC)
Stapedius and hyoid artery
43. From where is amniotic fluid produced? other than electrolytes and carbs - what else does it contain?
Week 4
Neuroectoderm
Maternally derived; meconium
Ectoderm - mesoderm - endoderm; epiblast - primitive streak - hypoblast; week 3
44. What two things cause VACTERL syndrome?
OCPS and maternal diabetes
Neuroectoderm
Failure to recanalize; 21
Cranio - caudal; segmental
45. From What embryonic layer does the gut tube epithelium arise?
Polyhydramnios
Amniotic epithelium
Endoderm
Persistence of 3rd cleft (groove) and pouch causes fistula between tonsillar area and cleft in lateral neck
46. what week do the genitalia start to have male/female characteristics? What trimester is that?
Urogenital sinus; wolffian duct; mullerian duct; urogenital sinus; wolffian duct; wolffian duct; mullerian; mullerian
Week 10-12; end of 1st trimester
Truncus arteriosus; pulmonary trunk
No organ in each; agenesis no primordial tissue
47. Where is the apical ectodermal ridge?
They are the edge of neural plate folding; all over the body
Neuroectoderm
Bilateral loss of pain and temperature sensation in upper extremities with preservation of touch sensation
Thickened ectoderm at end of each developing limb
48. What axis does the basal plate form? what neural system does it become?
Ventral ; motor
3rd and 4th arches
Aberrant development of 3rd and 4th pouches; t cell def (thymic aplasia) - hypocalcemia (failure of parathyroid development) - CF and CV defects
Thyroglossal duct; persists as pyramidal lobe of thyroid; foramen cecum on tongue is normal remnant of thyroglossal duct
49. what other facial defect other than cyclopia is associated with holoprosencephaly?
Embryonic period; 1st trimester
Neuroectoderm
Right horn of the SV
Cleft lip/palate
50. What two cavities also form during the second week?
Found in lateral neck; from no obliteration of 2-4th clefts
Common carotid and internal carotid
Metanephric mesenchyme; differentiation and formation of glomerulus and renal tubules to distal convoluted tubule
Amniotic cavity and yolk sac