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Test your basic knowledge |
USMLE Embryo
Start Test
Study First
Subjects
:
health-sciences
,
usmle
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. From What do the embryoblast and trophoblast form from? What does the embryoblast split into? the trophoblast?
Urogenital sinus; wolffian duct; mullerian duct; urogenital sinus; wolffian duct; wolffian duct; mullerian; mullerian
Blastocyst; epiblast and hypoblast; synctiotrophoblast and cytotrophoblast
Greater horn of hyoid; CN IX (styloPharyngeus)
Prosencephalon
2. Which branchial derivative accounts for the posterior 2/3 of the tongue?
Neural crest cells
Pronephros - mesonephros - metanephros; pronephros; most cranially
Medial palatine processes
3rd and 4th arches
3. Only _______________________________ are associated with neural tube defects
Endoderm
Ventral and dorsal parts fail to fuse at 8th week; 2 pancreatic ducts!- more prone to pancreatitis
Rhombencephalon
arnold chiari associated with thoraclumbar myelomeningocele
4. From which germlayer does the thyroid develop?? From what structure exactly?
Endoderm
Neural crest migration - they then cause spiral
Endoderm - floor of primitive pharynx
Tongue
5. What is the kidney that functions at the interim kidney in the 1st trimester? What does it later contribute to?
Mesonephros; male genital system
Mesoderm
Week 3-8
Nicotine; preterm labor
6. What causes the increase in left atrial pressure to close the fossa ovale?
Decreased pulmonary resistance in the pulmonary vasculature
Outgrowth of mesonephric as ureteric bud; most caudal
Prosencephalon - mesencephalon - rhombencephalon
3 -4 -6
7. From where does the pulmonary arteries and the ductus arteriosus arise?
Mental retardation - holoprosencephaly - facial features - fistulas
Medial palatine processes
Surface ectoderm
6th aortic arch
8. What hormones are in charge of external genitalia development in the fetus? (in both male and female)
Cytotrophoblast and synctiotrophoblast
Scrotum; labia majora
DHT; estrogen
2nd pouch
9. Which is more common - epispadias or hypospadias?
Neuroectoderm
Hypospadias
Prevent recurrent UTIs
Neuroectoderm
10. From where did a branchial cleft cyst arise if it found?
Day 6; with implantation
Maternally derived; meconium
Found in lateral neck; from no obliteration of 2-4th clefts
Lithium; valve leaflets attach to domain down low in RV- 'atrialized RV'
11. From where to Where is the foregut derivative? midgut? hindgut?
Pharynx to duodenum; duodenum to transverse colon; distal transverse colon to rectum
Neural crest cells
Ventral; failure of urogenital folds to close
Thyroid - cricoid - arytenoids - corniculate cuneiform
12. Cleft lip is a failure of fusion of ________ and ______.
Endoderm
Decidual basalis
Maxillary and medial nasal processes
Muscular ventricular septum; no
13. What are the two components of the placenta? From What do they form? which one secreted hcG?
...
Reicherts cartilage: Stapes - Styloid process - Lesser horn of hyloid - Stylohyoid ligament and CN VII
Deformation
Lithium; valve leaflets attach to domain down low in RV- 'atrialized RV'
14. What is the initial step to interventricular septum development? is it complete?
Metanephric mesenchyme; differentiation and formation of glomerulus and renal tubules to distal convoluted tubule
Decreased separation of hemispheres across midline; cyclopia
Muscular ventricular septum; no
Hypospadias
15. In order to survive tricuspid atresia - What do you need?
VSD
Neural plate; closes by week 4
Myelencephalon
Cytotrophoblast
16. WithIn what week does gastrulation occur? What is gastrulation?
Week 3; primitive streak formation from the epiblast makes the three layers
lumbosacral
Yolk sac; liver (weeks 6-30) and spleen (9-28 weeks)
Nicotine; preterm labor
17. Where is Wnt 7 gene produced?
Apical ectodermal ridge
Caused by compression on trocheal nerve - causes vertical gaze paralysis (associated with arnold chiari)
80%
Fluid filled syrinx causes expansion and degeneration of cord tracts
18. What is DiGeorge syndrome and What does it result in?
VACTERL- vertebral defect - anal atresia - cardiac defects - tracheo - esophageal fistula - renal defects - limb defects
Dorsal; sensory
Aberrant development of 3rd and 4th pouches; t cell def (thymic aplasia) - hypocalcemia (failure of parathyroid development) - CF and CV defects
Tongue
19. From What embryonic layer are the schwann cells from ?
Lacunae in between the chorionic villi
Allantois
Neural crest cells
Physiologic incomplete muscular ventricular septum
20. What hormone is hcG structurally similar too?
Endoderm
Lithium
OCPS and maternal diabetes
LH
21. What is meckel's diverticulum? What is it associated with? What does that cause?
Aortic arch (from left side); right subclavian (on the right)
External auditory meatus
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
Week 3; primitive streak formation from the epiblast makes the three layers
22. What causes a vesicourachal diverticulum? What is it?
Fetal kidney; fetal swallows - absorbs - and then removed from placental blood
Failure of the urachus to obliterate; outpouching of the bladder
Mid gut to yolk sac; omphalomesenteric duct; 7th week
Epiblast
23. From what aortic arch does the common carotid artery arise? what else arises from this arch?
Endoderm lined structures of ear: middle ear cavity - eustacian tube - mastoid air cells
Fallopian tube - uterus - upper 1/3 of vagina
3rd; proximal part of the internal carotid artery
Nutrient and gas for exchange; endometrium
24. By what week is there fetal movement?
Week 8
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
Transposition of great vessels (failure to spiral)- right to left shunt; tetralogy of Fallout (right to left shunt caused by skewed development of septum); persistent TA (partial septum development - also right to left shunt)
Found in lateral neck; from no obliteration of 2-4th clefts
25. What embryological structure gives rise to the trabeculated parts of the left and right ventricle?
Vascular accident intra uterine; apple peel atresia
Metencephalon; cerebellum
Primitive ventricle
Neural crest cells
26. What is the neural plate and From what does it form?
Failure of the urachus to obliterate
Ectoderm
Mesoderm
Neural crest cells
27. What type of blood do umbilical veins carry? From where to where?
is no longer intact
Temporary cervical sinus
Oxygenated; placenta to fetus (IVC)
Embryonic period; 1st trimester
28. In what chromosomal disorder is horseshoe kidney commonly seen? what poles of the kidneys fuse?
Turners; inferior
First branchial pouch
Fetal and maternal
DiGeorge
29. Which cranial nerve innervates the motor function of the tongue?
Initial left to right shunting - then switches
2; 1
Membrane - all 3 from 1st appartus
XII
30. What is the female remnant of processus vaginalis? male remnant?
Obliterated; forms tunica vaginalis
Muscular ventricular septum; no
Yolk sac; 3rd week
2; 1
31. What is omphalocele? In What trisomies is it seen?
lumbosacral
Before getting pregnant!
Persistance of herniation of abdominal contents into umbilical cord covered by peritoneum; 13 - 18
1st arch neural crest fails to migrate --> mandibular hypoplasia - facial abnormalities (cleft palate - decreased slanting of palpebral fissures)
32. What axis does the alar plate form? what neural system does it become?
When the AP septum meets and fuses with the muscular ventricular septum to form membranous intraventricular septum - closing interventricular foramen
Hypospadias
Dorsal; sensory
Umbilical artery - vein; and whartons jelly (mucus connective tissue) - urachus
33. By what week is the neural tube supposed to be closed? when did it start forming?
Week 4; week 3
Urachus/median umbilical ligament; bladder and yolk sac
Week 8
Foregut; dorsal mesentery (mesodermal)
34. What two things cause VACTERL syndrome?
OCPS and maternal diabetes
Fetal kidney; fetal swallows - absorbs - and then removed from placental blood
Mesencephalon
Renal artery stenosis;
35. What embryological structure gives rise to the trabeculated part of the left and right atrium?
28 week onward
The caudal end mesonephros; the ureter - pelvis - calyces - collecting ducts
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
Primitive atrium
36. What is associated with only one umbilical artery?
Blind upper esophagus with lower esophagus connected to trachea; cyanosis - choking and vomiting with feeding; air bubble on CXR; polyhydramnios; failure to pass NG tube; pneumonitis
Cranio - caudal; segmental
...
Congenital and chromosomal abnormalities
37. Other than not having a brain - what else is a symptom of anencephaly? why? hint: think about amniotic fluid
Obliterated; forms tunica vaginalis
6-30
Where the epiblast and hypoblast fuse
Polyhydramnios
38. what chemo drugs can cause neural tube defects in the fetus?
Folate antagonists
Neural crest cells
Gastric outlet obstruction (bilious vomiting - feeding intolerance - abdominal distention)
DiGeorge
39. Which branchial derivative creates the epithelial lining of the palatine tonsils?
Neuroectoderm
Fluid filled cavity in spinal cord; C8- T1; arnold chiari II
Grooves/clefts; arches; pouches
2nd pouch
40. what closes the interventricular foramen?
Outgrowth of mesonephric as ureteric bud; most caudal
Dorsal; faulty positioning of genital tubercle
Cerebellar tonsillar herniation through foramen magnum
Physiologic incomplete muscular ventricular septum
41. What two cavities also form during the second week?
Pronephros - mesonephros - metanephros; pronephros; most cranially
Deformation
Amniotic cavity and yolk sac
Epispadias
42. In both meningocele and myelomeningocele the dura...
Sonic Hedgehog
is no longer intact
Neural crest cells
Stapedius and hyoid artery
43. Where is the mothers blood located in the placenta?
Thyroglossal duct cysts will move with swallowing while persistent cervical sinuses in lateral neck wont
Initial left to right shunting - then switches
Lacunae in between the chorionic villi
Apical ectodermal ridge; limb lengthening; stimulates mitosis of underlying mesoderm
44. Which branchial derivative accounts for taste in the ant 2/3?
Bones - cartilage - and nerves
Foregut; dorsal mesentery (mesodermal)
Branchial arch 2
Week 8
45. From What embryonic layer are the cardiovascular - lymphatics and blood from?
Surface ectoderm
Occiptal
Mesoderm
Ectoderm; endoderm
46. which posterior fossa malformation results in aqueductal stenosis and hydrocephaly? what other spinal cord lesion does this malformation present with?
From teh lung;blood from IVC in RA to LA; fossa ovalis
Week 3-8
Endoderm
Arnold chiari; syringomyelia
47. Most myelomeningoceles present in the _______ region
Neuroectoderm
lumbosacral
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
Apical ectodermal ridge; limb lengthening; stimulates mitosis of underlying mesoderm
48. What are markers for neural tube defects in the amniotic cavity? CSF?
Blastocyst; epiblast and hypoblast; synctiotrophoblast and cytotrophoblast
Increased AFP and acetycholinesterase (not ACh!) in CSF
Caused by compression on trocheal nerve - causes vertical gaze paralysis (associated with arnold chiari)
septum primum and/or secundum
49. Which branchial apparatus develops into the superior parathyroids?
4th pouch
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
Persistent connection between amniotic cavity and spinal canal; low folic acid
Obliterated; forms tunica vaginalis
50. From what region does the midbrain form from?
Mesencephalon
...
Neural crest cells
Ventral and dorsal parts fail to fuse at 8th week; 2 pancreatic ducts!- more prone to pancreatitis
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