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Test your basic knowledge |
USMLE Embryo
Start Test
Study First
Subjects
:
health-sciences
,
usmle
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What are the two components of the placenta? From What do they form? which one secreted hcG?
Scrotum; labia majora
During; instrinsic
Umbilical artery - vein; and whartons jelly (mucus connective tissue) - urachus
...
2. From what does bicornuate uterus arise? What is it associated with?
Alkylating agents
Dorsal; faulty positioning of genital tubercle
Incomplete fusion of paramesonephric ducts; UT abnormalities and infertility
Duodenum to transverse colon; distal transverse colon to rectum
3. Cleft lip is a failure of formation of the...
primary palate
2nd pouch
Surface ectoderm
8
4. What is the homeobox gene responsible in developing? (What axis)
Cranio - caudal; segmental
Fetal kidney; fetal swallows - absorbs - and then removed from placental blood
Increase in oxygen concentration which decreases prostaglandin concentration
Maternally derived; meconium
5. What congenital abnormality forms a 'double bubble' on xray?
T neuroectoderm
...
Annular pancrease
Vascular accident intra uterine; apple peel atresia
6. What does the ductus venosus shunt blood away from? What is its remnant?
Urachus/median umbilical ligament; bladder and yolk sac
Hepatic circulation; ligamentum venosum
arnold chiari associated with thoraclumbar myelomeningocele
Thickened ectoderm at end of each developing limb
7. What is Treacher Collins syndrome? What is the result?
Prevent recurrent UTIs
1st arch neural crest fails to migrate --> mandibular hypoplasia - facial abnormalities (cleft palate - decreased slanting of palpebral fissures)
Neural crest cells
Muscles of Mastication: Temporalis - masseter - Lateral and Medila pterygoids - Mylohyoid - anterior belly of the digastric - tensor tympani - tensor veli palatini; ant 2/3 of tongue
8. What type of blood do umbilical arteries carry? From where to where?
Ectoderm; endoderm
Deoxygenated blood; fetal internal iliac arteries to placenta
Upper 1/3; urogenital sinus
Week 8
9. what bone/cartilage are derived from branchial arch 4-6?
Temporary cervical sinus
Greater horn of hyoid; CN IX (styloPharyngeus)
Thyroid - cricoid - arytenoids - corniculate cuneiform
Surface ectoderm
10. From What embryonic layer does the thyroid follicular cells arise?
Week 8
Sonic Hedgehog
1st cleft/groove (Ectoderm)
Endoderm
11. What is the mnueomonic for the mesodermal defects? What does it stand for?
Meckels cartilage: mandible - malleus - INCUS - sphenoMandibular ligament; CN V2 and V3
VACTERL- vertebral defect - anal atresia - cardiac defects - tracheo - esophageal fistula - renal defects - limb defects
Bulbourethral glands (of Cowper) and Prostate gland; greater vestibular glands (of Bartholin) and Urethral and paraurethral glands (of Skene)
Maxillary and medial nasal processes
12. When does organogenesis occur?
6th aortic arch
Nutrient and gas for exchange; endometrium
Week 3-8
Ventral ; motor
13. Which part of the chorionic villi can make cells?
Caused by compression on trocheal nerve - causes vertical gaze paralysis (associated with arnold chiari)
Cytotrophoblast
Week 2; bilaminar disk; epiblast and hypoblast
Endoderm
14. What are the three results of having pathology in the aorticopulmonary septum?
V3; VII
Transposition of great vessels (failure to spiral)- right to left shunt; tetralogy of Fallout (right to left shunt caused by skewed development of septum); persistent TA (partial septum development - also right to left shunt)
Initial left to right shunting - then switches
lumbosacral
15. Where is the decidua basalis derived from?
Week 2; bilaminar disk; epiblast and hypoblast
Muscular ventricular septum; no
During; instrinsic
Endometrium
16. What teratogens can cause flipper limbs (limb defects)? What is this drug used for?
Prostaglandins
Thalidomide; nausea
1st arch neural crest fails to migrate --> mandibular hypoplasia - facial abnormalities (cleft palate - decreased slanting of palpebral fissures)
2nd pouch
17. What is meckel's diverticulum? What is it associated with? What does that cause?
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
Failure to spiral (aorta coming out of RV and PA coming out of left ventricle)- two completely separate systems
is no longer intact
From the the lung; blood from SVC that went into RV gets shunted from pulm artery to aorta; ligamentum arteriosum
18. When is most important to take folic acid to prevent neural tube defects?
Before getting pregnant!
Failure of the urachus to obliterate; outpouching of the bladder
All or none
DiGeorge
19. From What embryonic layer does the epidermis arise?
Grooves/clefts; arches; pouches
4th week
Dorsal; faulty positioning of genital tubercle
Surface ectoderm
20. What type of - amnios does bilateral agenesis form? What three symptoms does this cause?
LH
Tunica vaginalis not fully fused
Oligohydramnios
Arches 3 and 4
21. what muscles are derived from branchial arch 6? CN?
4th arch; 6th arch
Ventral; failure of urogenital folds to close
Neural crest cells
All intrinsic muscles of larynx except cricothyroid; CN X (recurrent laryngeal nerve - speaking)
22. which genital embryology is default? From what duct? what duct degenerates without signal to stay?
Diencephalon
Lacunae in between the chorionic villi
Right common cardinal vein and right anterior cardinal vein
Female; paramesonephric; mesonephric
23. What arises from the fourth aortic arch?
Bulbos Cordis; right ventricle entirely
Increase in oxygen concentration which decreases prostaglandin concentration
Polyhydramnios - Down syndrome - Esophageal/duodenal atresia - Imperforate anus - Meckel diverticulum
Aortic arch (from left side); right subclavian (on the right)
24. What is an arnold chiari II malformation? through what hole does it herniate?
Female; paramesonephric; mesonephric
Failure of the urachus to obliterate
Cerebellar tonsillar herniation through foramen magnum
Lithium; valve leaflets attach to domain down low in RV- 'atrialized RV'
25. What hormones are in charge of external genitalia development in the fetus? (in both male and female)
Tongue
Branchial arch 2
DHT; estrogen
Neural crest cells
26. what junction is the last to canalize? what implications does this have down the line?
Annular pancrease
3rd pouch
Uretopelvis; most common site for obstruction (hydronephrosis) in fetus
Congenital and chromosomal abnormalities
27. In what chromosomal disorder is horseshoe kidney commonly seen? what poles of the kidneys fuse?
Partial closure of vitelline duct so that the patent portion is attached to ileum; ectopic gastric mucosa; melena and periumbilical pain
Congenital and chromosomal abnormalities
Neural crest cells
Turners; inferior
28. From What embryonic layer do the parafollicular cells of the thyroid arise?
4th arch; 6th arch
Neural crest cells
Blastocyst; epiblast and hypoblast; synctiotrophoblast and cytotrophoblast
Mesoderm; 3 week
29. what else is the caudal regression known as? What two teratogen can cause this in the fetus?
Pataus; fetal alcohol syndrome
Before getting pregnant!
VACTERL; OCPs and maternal diabetes
Metencephalon; cerebellum
30. What causes meconium discharge from the umbilicus?
Right common cardinal vein and right anterior cardinal vein
A vitelline fistula - failure of vitelline duct to close
4th arch; 6th arch
Endoderm
31. What is the difference between agenesis and aplasia?
Physiologic incomplete muscular ventricular septum
No organ in each; agenesis no primordial tissue
Neural crest migration - they then cause spiral
Ventral; failure of urogenital folds to close
32. From What embryonic layer does connective tissue and muscle arise?
Prostaglandins
Caused by compression on trocheal nerve - causes vertical gaze paralysis (associated with arnold chiari)
All or none
Mesoderm
33. On what side is the abnormal opening in epispadias? What causes it?
...
3rd; proximal part of the internal carotid artery
Right common cardinal vein and right anterior cardinal vein
Dorsal; faulty positioning of genital tubercle
34. What is the neural plate and From what does it form?
arnold chiari associated with thoraclumbar myelomeningocele
2; 1
Skewed development of AP septum
Ectoderm
35. what chemo drugs can cause neural tube defects in the fetus?
Neural crest cells
Valproate acid
Folate antagonists
Dorsal; faulty positioning of genital tubercle
36. From where does the medulla form?
Endoderm
A vitelline fistula - failure of vitelline duct to close
Glans penis and corpus cavernosum and spongiosum; glans clitoris and vestibular bulbs
Myelencephalon
37. What is the Eisenmeger complex?
Pulm art (prox) and ductus arteriosus
When left to right shunting switching to right to left shunting
3rd pouch
Incomplete fusion of paramesonephric ducts; UT abnormalities and infertility
38. What embryological structure gives rise to the trabeculated part of the left and right atrium?
Fetal and maternal
Metanephric mesenchyme; differentiation and formation of glomerulus and renal tubules to distal convoluted tubule
Primitive atrium
Surface ectoderm
39. What causes the decrease in Right atrial pressure to close the fossa ovale?
Neuroectoderm
No more umbilical circulation emptying into RA
Endoderm
Greater horn of hyoid; CN IX (styloPharyngeus)
40. What causes a large posterior fossa in a dandy walker malformation? What is found in this fossa?
SRY gene on Y chromosomes; sertoli and leydi; MIF and androgens; suppression of paramesonephric ducts and dev. of mesonephric (all respectively)
Dorsal ventral axis
Absent cerebellar vermis; cystic enlargement of 4th ventricle
Tetracyclines
41. What results in annular pancreas? How does it happen?
Endoderm
mesoderm
Arnold Chiari and Dandy Walker; Arnold Chiari; Dandy Walker; Arnold Chiari
Ring of pancreatic tissue can cause duodenal narrowing; ventral pancreatic bud abnormally encircles 2nd part of duodenum
42. What is the most common subtype of tracheoesophageal fistula? name some symptoms (hint: O2 levels - feeding - stomach on CXR - - amnios? - NG tube? - respiratory infection? )
OCPS and maternal diabetes
Arnold Chiari and Dandy Walker; Arnold Chiari; Dandy Walker; Arnold Chiari
Blind upper esophagus with lower esophagus connected to trachea; cyanosis - choking and vomiting with feeding; air bubble on CXR; polyhydramnios; failure to pass NG tube; pneumonitis
Partial AP septum development; one large vessel leaves the heart - Right to left shunt
43. What does the RET gene encode? what neoplasias is it associated with?
Neural crest development; MEN 2A (pheo - PTH tumor - parafollicular cell tumor)
Thyroid - cricoid - arytenoids - corniculate cuneiform
Meckels cartilage: mandible - malleus - INCUS - sphenoMandibular ligament; CN V2 and V3
Surface ectoderm
44. From What embryonic layer are the schwann cells from ?
Urachus/median umbilical ligament; bladder and yolk sac
Week 10-12; end of 1st trimester
Umbilical - midgut herniates through umbilical ring; SMA
Neural crest cells
45. What does the vitelline duct connect? What is it also known as? when should it obliterate?
When left to right shunting switching to right to left shunting
Neural crest development; MEN 2A (pheo - PTH tumor - parafollicular cell tumor)
Mid gut to yolk sac; omphalomesenteric duct; 7th week
Mesoderm; 3 week
46. What can vit A in excess cause in the fetus?
Lots - cleft palate/lip
6th aortic arch
Greater horn of hyoid; CN IX (styloPharyngeus)
Prevent recurrent UTIs
47. Which parts of the pancreas contribute to the head - uncinate process and main pancreatic duct?
Endoderm
Dorsal and ventral buds
Endoderm
4th arch; 6th arch
48. in hypospadias - on which side is the abnormal opening? What causes it?
20-50yrs - Abdominal pain - Postprandial fullness - Nausea - Peptic ulcers - Pancreatitis - Rarely - biliary obstruction
Ventral; failure of urogenital folds to close
Right horn of the SV
3 -4 -6
49. What is the defect in spina bifida occulta? is there any structural herniation? where on the spinal cord is it usually seen?
Failure of bony spinal canal to fuse; no; lower vertebral levels
Oxygenated; placenta to fetus (IVC)
Diencephalon
Truncus arteriosus; pulmonary trunk
50. At what week does the fetus look like a baby?
SRY gene on Y chromosomes; sertoli and leydi; MIF and androgens; suppression of paramesonephric ducts and dev. of mesonephric (all respectively)
Wolffian; mullerian
Week 8
Endoderm lined structures of ear: middle ear cavity - eustacian tube - mastoid air cells