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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Small diameter > large diameter; myelinated > unmyelinated
SE: elevated LFTS - myositis
basal nucleus of Meynert
MofA of N- aceylcysteine
order of nerve blockade

2. Medullary thyroid - pheochromocytoma - parathryoid
3 tumors of MEN 2a
TZD (glitazones) MofA
placenta previa
S cells

3. Gauchers
hallmark sign of COPD
astrocytes
PGI2 (prostacyclin))
most common lysosomal storage disease

4. Medulla
subluxation of lens
gram + bacteria that requires NAD and hemin for growth
most common breast tumor in women under 25
Where does the lateral corticospinal decussate?

5. 2 sperm + 1 egg (fetal parts present)
currant jelly stool
partial mole components
keratin filled cysts
21 hydroxylase deficiency

6. Serous cystadenocarcinoma
ovarian tumor with psammoma bodies
heXosaminidase
most common testicular tumor in infants and children up to 3 years of age
what meds treat malaria

7. Deficiency of aldosterone and cortisol

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8. Normal or candida
branching rods on oral infection
chromosome 4
cause of low pH vaginal discharge
subluxation of lens

9. Papillary CA of thyroid
order of nerve blockade
inheritance pattern for all MENs
benzos antidote
optically clear nuclei (orphan annie)

10. Gonorrhea
crinkled paper cytoplasm
thayer martin media
silver stain of gram negative rods
P450 inducers

11. Bind viral gp41 subunit
whats the V/Q at the base of the lung
most common gyno malignancy
currant jelly stool
fusion inhibitors

12. Ovarian bengin tumor...looks like bladder
most common lysosomal storage disease
brenner tumor
cause of increased myometrial excitability
blood supply for thalamus

13. Estrogen
inheritance pattern for all MENs
silver stain of gram negative rods
cause of increased myometrial excitability
P450 Inhibitors

14. 6- MP
drug that blocks purine synthesis and is metabolized by xanthine oxidase
anti - mitochondrial antibodies
Yolk sac tumor produces...
SE: elevated LFTS - myositis

15. Meningioma
complete mole components
most common testicular tumor
GABA - glutamine
brain tumor with psammona bodies

16. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
erythema nodosum
oligodendrioglia
GM2 ganglioside accumulation
fusion inhibitors

17. Fibroadenoma
most common breast tumor in women under 25
defective tyrosine kinase
most common lysosomal storage disease
3 tumors of MEN 1

18. Dimercaprol
papillary thyroid cancer
lead antidote
opioids antidote
LT C4 D4 E4

19. ADPKD
mitral valve prolapse - liver diseae - berry aneurysm
low dose ASA effects - intermediate dose - high dose
found in hairless skin
pigmented iris hamartomas - neural tumors

20. Niacins
complete mole components
best effect on HDL
paraventricular nucleus of hypothalamus
hippocampus

21. Yolk sac
glycine
LT C4 D4 E4
most common testicular tumor in infants and children up to 3 years of age
floppy mitral valve dissecting aortic aneurysm - berry aneurysm

22. Fibrocystic
locus ceruleus
SE: torsades de pointes
most common breast mass in pre - menopausal women
complete mole components

23. Medullary
cancer arising from parafollicular C cells
UMN signs
first line for cardiogenic shock
form multinucleated giant cells in the CNS when infected with HIV

24. D cells of pancreas and gut
what cells secrete somatostatin
cells destroyed in Guillain Barre
found in hairless skin
strawberry tongue

25. Actinomyces
propylthiouracil side effects
polyhydramnios
vasculitis a/w Hep B
branching rods on oral infection

26. Microglia
S cells
dorsal motor nucleus
ovarian tumor with elevate hCG
form multinucleated giant cells in the CNS when infected with HIV

27. Tay SaX
heXosaminidase
resembles an onion in cross section
sumatriptan
sclerosing adenosis

28. Lactic acidosis
t - PA - streptokinase antidote
hemosiderinurea and thrombosis
psammoma bodies
metformin side effect

29. Medulla
Where does the dorsal column decussate?
cancer associated with Hashimoto's thyroiditis
defective tyrosine kinase
barbituates withdrawal

30. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
cause of LH surge
locus ceruleus
LTB4
astrocytes

31. PNH
cause of low pH vaginal discharge
I cells
hemosiderinurea + thrombosis
chromosome 4

32. Fabry's & Hunters
x- linked recessive lysosomal storage diseases
iduronidase sulfatase
eczema/recurrent infections/thrombocytopenia
most common gyno malignancy

33. HTN; XY will be a girl - XX will lack secondary sex char.
Conn's syndrome
PTU
papillary thyroid cancer
17 alpha hydroxylase deficiency

34. Secretin
Aschoff bodies
S cells
whats the V/Q at the apex of the lung
5 alpha reductase deficiency

35. 5- fluorouracil
anti - epithelial antibodies
x- linked recessive lysosomal storage diseases
thymidylate synthase
sulfonylureas MofA

36. Schwann cells
t - PA - streptokinase antidote
hemosiderinurea + thrombosis
GM2 ganglioside accumulation
myelinates on PNS

37. Trichomonas or bacterial vaginosis
chief cells
3 tumors of MEN 2b
anti - mitochondrial antibodies
cause of high pH vaginal discharge

38. Weakness - atrophy - fasiculations - decreased reflexes & tone
alpha galacosidase A
LMN signs
meissners
sturge weber syndrome

39. Papillary
thyroid cancer associtated with RET oncogene
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
Schiller Duval bodies
brain tumor with perivascular pseudorosettes

40. Centriacinar
basal nucleus of Meynert
smoking emphysema
S cells
alpha L iduronidase

41. 2 sperm + empty egg (no fetal parts)
3 tumors of MEN 2a
antibody against philadelphia chromosome
complete mole components
Shigella

42. Huntingtons chorea
dermatin sulfate accumulation
chromosome 4
most common protozoal infection in US
ovarian tumor with psammoma bodies

43. Suspensory ligament of ovaries
contains ovarian vessels
what cells secrete somatostatin
ventral posterior nucleus - lateral part
SE: elevated LFTS - myositis

44. Autosomal dominant
deficiency of mannose phosphorylation
inheritance pattern for all MENs
chief cells
PGI2 (prostacyclin))

45. Oligosaccaride hydrolase
brain tumor with foamy cells and high vascularity
SE: torsades de pointes
rate limiting step in carb digestion
ovarian tumor with psammoma bodies

46. Fibrates
GABA - glutamine
best effect of triglycerides/VLDL
hemosiderinurea + thrombosis
papillary thyroid cancer

47. Superchiasmic nucleus
UMN signs
SE: facial flushing
master clock for circadian rhythms
dorsal motor nucleus

48. Krabbe's
Galactocerebrosidase deficiency
P450 inducers
fusion inhibitors
currant jelly stool

49. Regenerates glutathione
Schiller Duval bodies
what inhibits prolactin secretion
t - PA - streptokinase antidote
MofA of N- aceylcysteine

50. Sotalol - quinidine - cisapride
testicular tumor that can present with gynecomastia
sulfonylureas MofA
SE: torsades de pointes
probenecid