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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Hypoglycemia
SE: elevated LFTS - myositis
astrocytes
fusion inhibitors
sulfonylureas side effect

2. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
opioids antidote
BCG PQRS
hydrocele
basal nucleus of Meynert

3. Actinomyces
found in hairless skin
thromboxane A2
beta glucocerebrosidase
branching rods on oral infection

4. Aplastic anemia - rash - agranulocytosis
propylthiouracil side effects
sclerosing adenosis
tumor composed of cytotrophoblasts and syncytiotrophoblasts
myelinates on PNS

5. Oculomotor
drug that blocks purine synthesis and is metabolized by xanthine oxidase
cancer arising from parafollicular C cells
which nerve lifts the eyelid?
lewy body composition

6. Seborric keratosis
MofA of N- aceylcysteine
papillary thyroid cancer
keratin filled cysts
increased MCHC and hemolytic anemia

7. Most common type of thyroid cancer
spike and dome on microscope
papillary thyroid cancer
LTB4
vasculitis a/w Hep B

8. Vibration - pressure
hep B seropositivity in 30% of patients
probenecid
pacinian
iduronidase sulfatase

9. Ependymoma
UMN signs
brain tumor with perivascular pseudorosettes
benzos antidote
HELLP syndrome

10. ACE inhibitors
cause of increased myometrial excitability
epithelial
polyhydramnios
shown to slow progression of diabetic neuropathy

11. Papillary
thyroid cancer associtated with RET oncogene
Shigella
sarcoma botyroides
locus ceruleus

12. Attachment of placenta to lower uterine segment
P450 inducers
Abciximab
preeclampsia
placenta previa

13. Oligodendoglia
myelinates multiple CNS axons
what inhibits prolactin secretion
lewy body composition
enzyme used to conjugate bilirubin

14. Damaged in Guillian Barre
branching rods on oral infection
infliximab
schwann cells
first line for cardiogenic shock

15. Superchiasmic nucleus
homer wright rosettes
iduronidase sulfatase
master clock for circadian rhythms
lead antidote

16. Cell type involved in most ovarian tumors
hep B seropositivity in 30% of patients
epithelial
What hormones share a common alpha subunit
what checkpoint is p53 involved with?

17. Facial sensation (Make up on your face)
ventral posterior nucleus - medial part
child with eczema - coarse facial features - cold abscesses
Shigella
leydig cell tumor

18. SCID
child with eczema - coarse facial features - cold abscesses
cancer associated with Hashimoto's thyroiditis
subluxation of lens
locus ceruleus

19. Motor innervation of pharynx - larynx and upper esophagus
child with eczema - coarse facial features - cold abscesses
sclerosing adenosis
whats the V/Q at the apex of the lung
ambiguous nucleus

20. Dubin Johnson
hemosiderinurea + thrombosis
von Hippel Lindau disease
sphingomyelinase deficiency
grossly black liver

21. Gonorrhea
infliximab
iduronidase sulfatase
5 alpha reductase deficiency
thayer martin media

22. Kawasaki (treat with high dose aspirin)
strawberry tongue
kluver bucy
most common bacteria in GI tract
heparin antidote

23. Tay Sachs
chromosome 4
tumor with call - exner bodies
GM2 ganglioside accumulation
HELLP syndrome

24. 3
catalase positive coagulase negative
child with eczema - coarse facial features - cold abscesses
polyhydramnios
whats the V/Q at the apex of the lung

25. Trichomonas or bacterial vaginosis
fusion inhibitors
increased MCHC and hemolytic anemia
child with partial albinism - peripherial neuropathy - recurrent infections
cause of high pH vaginal discharge

26. HTN; masculinization
oligodendrioglia
11 beta hydroxylase deficiency
supraoptic nucleus of hypothalamus
Bisphosphonates MofA

27. Neurofibromatosis
thromboxane A2
microglia
found in hairless skin
lisch nodules

28. ITP
What thyroid pathology has an extremely tender thyroid gland
lead antidote
anti - platelet antibodies
myelinates on PNS

29. Fabrys
basal nucleus of Meynert
Abciximab
GM2 ganglioside accumulation
alpha galacosidase A

30. BCG PQRS
heparin antidote
P450 inducers
alpha galacosidase A
SICK PEG

31. Dopamine
cause of malignant hyperthermia
FGFR3 mutation
macrolides use (PUS)
MPTP exposure causes depletion of what NT?

32. Choriocarcinoma or dysgerminoma
21 hydroxylase deficiency
ovarian tumor with elevate hCG
cells destroyed in MS
pacinian

33. NF 1
found in hairless skin
cough - conjunctivitis - coryza - fever
basal nucleus of Meynert
pigmented iris hamartomas - neural tumors

34. Gauchers
SE: torsades de pointes
17 alpha hydroxylase deficiency
beta glucocerebrosidase
P450 Inhibitors

35. Homocystienuria - Marfans
subluxation of lens
most common lysosomal storage disease
adenomyosis
3 tumors of MEN 1

36. 2 sperm + 1 egg (fetal parts present)
brain tumor with foamy cells and high vascularity
palisading nuclei - locally invasive
partial mole components
gram + bacteria that requires NAD and hemin for growth

37. Lymphoma

38. Meissner
S cells
nucleoside reverse transcriptase inhibitors
found in hairless skin
LTB4

39. Marfans
ventral posterior nucleus - lateral part
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
protease inhibitors MofA
most common arrthymia

40. Aminocaproic acid
GABA - glutamine
lysosomal storage disease a/w renal disease
t - PA - streptokinase antidote
tumor composed of cytotrophoblasts and syncytiotrophoblasts

41. Parathyroid - pituitary - pancreatic
3 tumors of MEN 1
brain tumor with fried egg appearance
what meds treat malaria
dorsal motor nucleus

42. Trichomonas - Giardia
PTU
locus ceruleus
most common protozoal infection in US
von Hippel Lindau disease

43. Glucuronyl transferase
cancer arising from parafollicular C cells
enzyme used to conjugate bilirubin
heXosaminidase
optically clear nuclei (orphan annie)

44. Decreases conversion
PTU
hep B seropositivity in 30% of patients
eczema/recurrent infections/thrombocytopenia
parietal cells

45. Ach
basal nucleus of Meynert
sturge weber syndrome
whats the V/Q at the base of the lung
raphe nucleus

46. Impetigo
SE: elevated LFTS - myositis
GFAP positive
honey crusted lesions common around nose/lips
oligodendrioglia

47. Clopidogrel - ticoplidine
honey crusted lesions common around nose/lips
blocks ADP receptors to inhibit platelet aggregation
sturge weber syndrome
SE: elevated LFTS - myositis

48. Chloroquine and primaquine
enzyme used to conjugate bilirubin
what meds treat malaria
thymidylate synthase
most common breast tumor in women under 25

49. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
sumatriptan
palisading nuclei - locally invasive
cancer associated with Hashimoto's thyroiditis
colchicine

50. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
oligodendrioglia
sulfonylureas MofA
11 beta hydroxylase deficiency
glycine