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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Protamine sulfate
FGFR3 mutation
heparin antidote
treatment for SIADH
optically clear nuclei (orphan annie)

2. 5- fluorouracil
what cells secrete somatostatin
deficiency of mannose phosphorylation
thayer martin media
thymidylate synthase

3. Criglar Najar
ambiguous nucleus
thyroid cancer associtated with RET oncogene
child with partial albinism - peripherial neuropathy - recurrent infections
absent UTPGT

4. Babinski - weakness - increased reflexes & tone - spastic paralysis
thromboxane A2
astrocytes
UMN signs
LTB4

5. Trigeminal
most common lysosomal storage disease
mildly decreased UDPGT
hydatidiform mole with crazy high hCG
what nerve innervates the muscles of mastication?

6. Estrogen
cause of LH surge
basal nucleus of Meynert
propylthiouracil side effects
anti - epithelial antibodies

7. Body sensation
most common breast mass in pre - menopausal women
ventral posterior nucleus - lateral part
alpha 1 anti - trypsin
eczema/recurrent infections/thrombocytopenia

8. Radial nerve - deep brachial artery
raphe nucleus
lewy body composition
midshaft break of humerus
GFAP positive

9. Metachromatic leukodystrophy
Aschoff bodies
ovarian tumor that resembles bladder epithelium
21 hydroxylase deficiency
lysosomal storage disease - demyelinating disease

10. Flumazenil
propylthiouracil side effects
lead antidote
benzos antidote
17 alpha hydroxylase deficiency

11. Gauchers
BCG PQRS
pacinian
most common lysosomal storage disease
pseudopalisading necrosis

12. Placenta attached to myometrium
meissners
hallmark sign of COPD
cause of low pH vaginal discharge
plenta accreta

13. Endometrial CA
catalase positive coagulase negative
best effect on HDL
most common gyno malignancy
most common testicular tumor in infants and children up to 3 years of age

14. D cells of pancreas and gut
paraventricular nucleus of hypothalamus
S cells
what cells secrete somatostatin
SE: torsades de pointes

15. Increased acini and intralobular fibrosis
colchicine
Where does the spinothalamic decussate?
sclerosing adenosis
precursor to GABA

16. Decreased potency - increased Km
locus ceruleus
sclerosing adenosis
intranuclear inclusions seen in herpes simplex encephalitis
dose response curve change with competitive antagonist

17. Actinomyces
P450 inducers
heXosaminidase
branching rods on oral infection
most common lysosomal storage disease

18. Meissner
Schiller Duval bodies
found in hairless skin
adenomyosis
What causes coronary vasospasm as a SE?

19. Macrolides
ambiguous nucleus
antibiotic with SE of eosinophilia
metformin side effect
bocks PRPP synthetase to block purine synthesis

20. Rheumatic fever
Aschoff bodies
SE: torsades de pointes
contains ovarian vessels
smoking emphysema

21. Brenners tumor
anti - platelet antibodies
alpha L iduronidase
beta glucocerebrosidase
ovarian tumor that resembles bladder epithelium

22. G1/S & G2/M
may lead to multiple personalities
brain tumor with perivascular pseudorosettes
what checkpoint is p53 involved with?
strawberry tongue

23. Demeclycocycline or water restriction
most common bacteria in GI tract
most common breast cancer
Aschoff bodies
treatment for SIADH

24. Hurlers
locus ceruleus
Where does the dorsal column decussate?
H. flu
corneal clouding & MR

25. Inhibits viral assembly
ependymal cells
anti - mitochondrial antibodies
protease inhibitors MofA
LMN signs

26. Leydig cell tumor
what checkpoint is p53 involved with?
looks like fried eggs under histologic staining
what nerve innervates the muscles of mastication?
testicular tumor that can present with gynecomastia

27. Primary hyperaldosteronism (HTN - hypokalemia - metabolic alkalosis)

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28. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
preeclampsia
astrocytes
follicular
GM2 ganglioside accumulation

29. Cells of BBB
alpha L iduronidase
astrocytes
what nerve innervates the muscles of mastication?
SE: torsades de pointes

30. Yolk sac
most common testicular tumor in infants and children up to 3 years of age
blocks ADP receptors to inhibit platelet aggregation
ovarian tumor with psammoma bodies
lysosomal storage disease a/w renal disease

31. Oligodendrioma
brain tumor with fried egg appearance
probenecid
smoking emphysema
homer wright rosettes

32. Legionella
most common lysosomal storage disease
silver stain of gram negative rods
cause of low pH vaginal discharge
dermatin sulfate accumulation

33. Somatostatin
lisch nodules
preeclampsia
D cells
intranuclear inclusions seen in herpes simplex encephalitis

34. Glioblastoma multiforme
Bisphosphonates MofA
hippocampus
testicular tumor that can present with gynecomastia
pseudopalisading necrosis

35. Staph epidermidis - staph sapro
paraventricular nucleus of hypothalamus
catalase positive coagulase negative
dose response curve change with competitive antagonist
what nerve innervates the muscles of mastication?

36. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
What hormones share a common alpha subunit
PGI2 (prostacyclin))
contains ovarian vessels
What are the hormone changes seen in menopause

37. Negri bodies
von Hippel Lindau disease
rabies
opioid withdrawal
Conn's syndrome

38. Parathyroid - pituitary - pancreatic
resembles an onion in cross section
3 tumors of MEN 1
brain tumor with foamy cells and high vascularity
GM2 ganglioside accumulation

39. Job's or LAD
P450 inducers
GABA - glutamine
neutrophils fail to respond to chemotaxic stimuli
most common breast mass in pre - menopausal women

40. 6- mecaptopurine (metabolized by xanthine oxidase)
PGI2 (prostacyclin))
probenecid
11 beta hydroxylase deficiency
bocks PRPP synthetase to block purine synthesis

41. Increases platelet aggregation and vasoconstriction
what cells secrete somatostatin
barbituates withdrawal
thromboxane A2
smoking emphysema

42. Complete
hydatidiform mole with crazy high hCG
partial mole components
lewy body composition
paraventricular nucleus of hypothalamus

43. Dubin Johnson
grossly black liver
GABA - glutamine
enzyme used to conjugate bilirubin
H. flu

44. Pepsin
Bisphosphonates MofA
chief cells
diphtheria treatment
most common breast cancer

45. Incomplete fusion of processus vaginalis
Aschoff bodies
hydrocele
PTU
What causes coronary vasospasm as a SE?

46. Actinomyces
blood supply for thalamus
dermatin sulfate accumulation
branching rods on oral infection
bocks PRPP synthetase to block purine synthesis

47. A/w esophageal/duodenal atresia and anencephaly
etanercept
polyhydramnios
most common gyno malignancy
thymidylate synthase

48. Impetigo
melanoma tumor marker
lysosomal storage disease a/w renal disease
honey crusted lesions common around nose/lips
anti - mitochondrial antibodies

49. Suspensory ligament of ovaries
most common testicular tumor
G cells
leydig cell tumor
contains ovarian vessels

50. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
tumor with call - exner bodies
glycine
anti - epithelial antibodies
LT C4 D4 E4