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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. I- cell disease
Abciximab
leydig cell tumor
deficiency of mannose phosphorylation
paraventricular nucleus of hypothalamus

2. Microglia
form multinucleated giant cells in the CNS when infected with HIV
macrolides use (PUS)
paraventricular nucleus of hypothalamus
metformin side effect

3. 2 sperm + 1 egg (fetal parts present)
pt has extended expiratory phase
SICK PEG
3 tumors of MEN 2b
partial mole components

4. Papillary CA of thyroid
master clock for circadian rhythms
myelinates on PNS
erythema nodosum
optically clear nuclei (orphan annie)

5. Serotonin
ventral posterior nucleus - lateral part
PTU
raphe nucleus
most common protozoal infection in US

6. Primary biliary cirrhosis
blood supply for thalamus
LTB4
tumor composed of cytotrophoblasts and syncytiotrophoblasts
anti - mitochondrial antibodies

7. Basal cell carcinoma
which nerve lifts the eyelid?
tumor with call - exner bodies
palisading nuclei - locally invasive
lead antidote

8. SCID
pigmented iris hamartomas - neural tumors
child with eczema - coarse facial features - cold abscesses
copper - arsenic - gold antidote
oligodendrioglia

9. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
most common breast cancer
kawasaki
alpha 1 anti - trypsin
Galactocerebrosidase deficiency

10. Achondroplasia
anti - epithelial antibodies
What causes coronary vasospasm as a SE?
beta glucocerebrosidase
FGFR3 mutation

11. Pneumonia - URIs - STDS
shown to slow progression of diabetic neuropathy
found in hairless skin
macrolides use (PUS)
midshaft break of humerus

12. Hurlers
antibody against philadelphia chromosome
corneal clouding & MR
Abciximab
tumor composed of cytotrophoblasts and syncytiotrophoblasts

13. Somatostatin
master clock for circadian rhythms
leydig cell tumor
subluxation of lens
D cells

14. Alpha synuclein
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
hemosiderinurea + thrombosis
brenner tumor
lewy body composition

15. Gastrin
lysosomal storage disease - demyelinating disease
G cells
pacinian
sulfonylureas side effect

16. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
antibiotic with SE of eosinophilia
myelinates on PNS
adenomyosis
LT C4 D4 E4

17. Protamine sulfate
myelinates on PNS
sulfonylureas MofA
thayer martin media
heparin antidote

18. Meissner
preeclampsia
most common first line agent for septic shock
most common breast mass in postmenopausal women
found in hairless skin

19. Decreases conversion
PTU
sturge weber syndrome
astrocytes
astrocytes

20. Krabbe's
SE: facial flushing
Galactocerebrosidase deficiency
treatment of malignant hyperthermia
cause of low pH vaginal discharge

21. Fibrates/statins
Where does the spinothalamic decussate?
LT C4 D4 E4
SE: elevated LFTS - myositis
MPTP exposure causes depletion of what NT?

22. Ependymoma
cause of LH surge
brain tumor with perivascular pseudorosettes
complete mole components
increased MCHC and hemolytic anemia

23. Hereditary spherocytosis
hemosiderinurea + thrombosis
increased MCHC and hemolytic anemia
first line for absence seizures
17 alpha hydroxylase deficiency

24. Vibration - pressure
ovarian tumor with psammoma bodies
17 alpha hydroxylase deficiency
sarcoma botyroides
pacinian

25. Aplastic anemia - rash - agranulocytosis
brain tumor with perivascular pseudorosettes
propylthiouracil side effects
sulfonylureas side effect
cause of malignant hyperthermia

26. Ret
failure of endodermal development
S cells
What oncogene is a/w MEN 2a/b
t - PA - streptokinase antidote

27. Von Hippel Lindau
lewy body composition
lisch nodules
best effect on HDL
hemangioblastomas of retina/cerebellum/medulla

28. SICK PEG
P450 Inhibitors
sturge weber syndrome
brain tumor with fried egg appearance
what inhibits prolactin secretion

29. Causes vasoconstriction (use for acute migraines)
subluxation of lens
kluver bucy
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
sumatriptan

30. Medullary
cancer arising from parafollicular C cells
Conn's syndrome
pt has extended expiratory phase
rabies

31. Basilar
Lewy bodies composition
What artery causes locked in syndrome
t - PA - streptokinase antidote
polyhydramnios

32. Inner lining of ventricles - make CSF - originate from neuroectoderm
locus ceruleus
alpha L iduronidase
mildly decreased UDPGT
ependymal cells

33. Invasive ductal
rate limiting step in carb digestion
ependymal cells
most common breast cancer
branching rods on oral infection

34. ACE inhibitors
LTB4
GFAP positive
sclerosing adenosis
shown to slow progression of diabetic neuropathy

35. Measles
pt has extended expiratory phase
most common testicular tumor in infants and children up to 3 years of age
inheritance pattern for all MENs
cough - conjunctivitis - coryza - fever

36. Glucuronyl transferase
brain tumor with foamy cells and high vascularity
anti - platelet antibodies
enzyme used to conjugate bilirubin
Aschoff bodies

37. Gauchers
hydrocele
corneal clouding & MR
beta glucocerebrosidase
cancer associated with Hashimoto's thyroiditis

38. Metachromatic leukodystrophy
thayer martin media
Where does the lateral corticospinal decussate?
lysosomal storage disease - demyelinating disease
erythema nodosum

39. Yolk sac tumor
antibody against philadelphia chromosome
what cells secrete somatostatin
most common testicular tumor
Schiller Duval bodies

40. Hypoglycemia
sturge weber syndrome
raphe nucleus
abruptio placentae
sulfonylureas side effect

41. Bilateral renal agenesis or posterior urethral valves in males
colchicine
ventral posterior nucleus - lateral part
oligohydramnios
most common breast tumor in women under 25

42. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
cause of malignant hyperthermia
GM2 ganglioside accumulation
astrocytes
looks like fried eggs under histologic staining

43. NF 1
hemosiderinurea and thrombosis
pigmented iris hamartomas - neural tumors
etanercept
Conn's syndrome

44. Anxiety - seizures - delirium - life threatening CV collapse
paraventricular nucleus of hypothalamus
barbituates withdrawal
optically clear nuclei (orphan annie)
tumor composed of cytotrophoblasts and syncytiotrophoblasts

45. HTN; XY will be a girl - XX will lack secondary sex char.
Addison's
deficiency of mannose phosphorylation
testicular tumor that can present with gynecomastia
17 alpha hydroxylase deficiency

46. Hemolysis - elevated LFTs - Low Platelets
chromosome 4
HELLP syndrome
most common breast mass in postmenopausal women
SE: torsades de pointes

47. Intrinsic factor
child with eczema - coarse facial features - cold abscesses
etanercept
opioids antidote
parietal cells

48. Motor innervation of pharynx - larynx and upper esophagus
heXosaminidase
ambiguous nucleus
lead antidote
contains ovarian vessels

49. Posterior communicating - posterior cerebral - anterior choroidal arteries
most common first line agent for septic shock
blood supply for thalamus
sumatriptan
deficiency of mannose phosphorylation

50. Atrial fibrillation
MofA Levothyroxine
brain tumor with fried egg appearance
lead antidote
most common arrthymia

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USMLE Pathophys

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