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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Pemphigus vulgaris
anti - epithelial antibodies
lisch nodules
cause of high pH vaginal discharge
What thyroid pathology has an extremely tender thyroid gland

2. Membranous GN
21 hydroxylase deficiency
H. flu
whats the V/Q at the apex of the lung
spike and dome on microscope

3. Marfans
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
GM2 ganglioside accumulation
blood supply for thalamus
mildly decreased UDPGT

4. Vibration - pressure
P450 inducers
pacinian
what inhibits prolactin secretion
diphtheria treatment

5. Ret
What oncogene is a/w MEN 2a/b
Lewy bodies composition
mildly decreased UDPGT
medial geniculate nucleus

6. Decreases conversion
branching rods on oral infection
absent UTPGT
catalase positive coagulase negative
PTU

7. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
most common lysosomal storage disease
enzyme used to conjugate bilirubin
psammoma bodies
propylthiouracil side effects

8. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
GM2 ganglioside accumulation
alpha 1 anti - trypsin
colchicine
anti - mitochondrial antibodies

9. Demeclycocycline or water restriction
treatment for SIADH
What thyroid pathology has an extremely tender thyroid gland
kawasaki
complete mole components

10. Benign - contains Reinke crystals - usually androgen producing
fusion inhibitors
follicular
leydig cell tumor
ambiguous nucleus

11. Meissner
found in hairless skin
preeclampsia
optically clear nuclei (orphan annie)
S cells

12. Decreased potency - increased Km
Lateral geniculate nucleus
bocks PRPP synthetase to block purine synthesis
dose response curve change with competitive antagonist
11 beta hydroxylase deficiency

13. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
medial geniculate nucleus
11 beta hydroxylase deficiency
erythema nodosum
most common bacteria in GI tract

14. HTN - proteinuria - edema
smoking emphysema
What are the hormone changes seen in menopause
preeclampsia
brain tumor with psammona bodies

15. 6- mecaptopurine (metabolized by xanthine oxidase)
Conn's syndrome
I cells
bocks PRPP synthetase to block purine synthesis
cough - conjunctivitis - coryza - fever

16. Granulosa cell tumor
chief cells
tumor composed of cytotrophoblasts and syncytiotrophoblasts
kawasaki
tumor with call - exner bodies

17. Astrocytoma & glioblastoma multiforme
looks like fried eggs under histologic staining
cough - conjunctivitis - coryza - fever
most common testicular tumor in infants and children up to 3 years of age
GFAP positive

18. Ach
Yolk sac tumor produces...
basal nucleus of Meynert
most common breast mass in postmenopausal women
glycine

19. Masculinization - hypovolemic shock
enzyme used to conjugate bilirubin
21 hydroxylase deficiency
best effect of triglycerides/VLDL
first line for cardiogenic shock

20. DiGeorge
hydatidiform mole with crazy high hCG
chromosome 4
sclerosing adenosis
failure of endodermal development

21. Norepinephrine
alpha galacosidase A
neutrophils fail to respond to chemotaxic stimuli
increased MCHC and hemolytic anemia
locus ceruleus

22. Primary biliary cirrhosis
defective tyrosine kinase
anti - mitochondrial antibodies
basal nucleus of Meynert
branching rods on oral infection

23. Gauchers
beta glucocerebrosidase
SE: facial flushing
most common bacteria in GI tract
optically clear nuclei (orphan annie)

24. G1/S & G2/M
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
G cells
what checkpoint is p53 involved with?
VA/VL

25. Metachromatic leukodystrophy
most common first line agent for septic shock
neutrophils fail to respond to chemotaxic stimuli
lysosomal storage disease - demyelinating disease
erythema nodosum

26. Estrogen (causes precocious puberty)
PTU
granulosa cell tumor secretes what?
intranuclear inclusions seen in herpes simplex encephalitis
abruptio placentae

27. Dubin Johnson
grossly black liver
schwann cells
lysosomal storage disease - demyelinating disease
Where does the lateral corticospinal decussate?

28. Hemolysis - elevated LFTs - Low Platelets
ambiguous nucleus
HELLP syndrome
raphe nucleus
SE: torsades de pointes

29. HTN; masculinization
beta glucocerebrosidase
11 beta hydroxylase deficiency
erythema nodosum
hemangioblastomas of retina/cerebellum/medulla

30. Suspensory ligament of ovaries
contains ovarian vessels
hippocampus
bocks PRPP synthetase to block purine synthesis
antibiotic with SE of eosinophilia

31. Lactic acidosis
whats the V/Q at the apex of the lung
eczema/recurrent infections/thrombocytopenia
metformin side effect
GABA - glutamine

32. A/w esophageal/duodenal atresia and anencephaly
locus ceruleus
polyhydramnios
What hormones share a common alpha subunit
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

33. Deficiency of aldosterone and cortisol

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34. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
drug induced lupus
3 tumors of MEN 2b
What are the hormone changes seen in menopause
I cells

35. Inhibitory in the brain - stimulatory in the brain
neutrophils fail to respond to chemotaxic stimuli
GABA - glutamine
treatment of malignant hyperthermia
GM2 ganglioside accumulation

36. Protamine sulfate
sumatriptan
Lewy bodies composition
heparin antidote
cause of malignant hyperthermia

37. Increased acini and intralobular fibrosis
sclerosing adenosis
Aschoff bodies
glycine
contains ovarian vessels

38. A few levels above the level of entry
brain tumor with foamy cells and high vascularity
Where does the spinothalamic decussate?
dorsal motor nucleus
SE: facial flushing

39. Ach
hemangioblastomas of retina/cerebellum/medulla
tumor composed of cytotrophoblasts and syncytiotrophoblasts
UMN signs
basal nucleus of Meynert

40. Measles
anti - mitochondrial antibodies
cough - conjunctivitis - coryza - fever
may lead to multiple personalities
oligohydramnios

41. Choriocarcinoma
tumor composed of cytotrophoblasts and syncytiotrophoblasts
best effect of triglycerides/VLDL
cells destroyed in Guillain Barre
resembles an onion in cross section

42. Basal cell carcinoma
barbituates withdrawal
palisading nuclei - locally invasive
failure of endodermal development
granulosa cell tumor secretes what?

43. Legionella
corneal clouding & MR
anti - epithelial antibodies
silver stain of gram negative rods
strawberry tongue

44. B. fragilis
sturge weber syndrome
intranuclear inclusions seen in herpes simplex encephalitis
blocks ADP receptors to inhibit platelet aggregation
most common bacteria in GI tract

45. Babinski - weakness - increased reflexes & tone - spastic paralysis
FGFR3 mutation
dose response curve change with competitive antagonist
tram - track on microscope
UMN signs

46. Cavernous hemangiomas in skin - mucosa & organs; autosomal dominant - a/w renal CA - hemangioblastoma in retina - brainstem & cerebellum
gram + bacteria that requires NAD and hemin for growth
form multinucleated giant cells in the CNS when infected with HIV
VA/VL
von Hippel Lindau disease

47. Microglia
sturge weber syndrome
dose response curve with noncompetitive antagonist
metformin side effect
form multinucleated giant cells in the CNS when infected with HIV

48. Yolk sac tumor
Schiller Duval bodies
shown to slow progression of diabetic neuropathy
Galactocerebrosidase deficiency
Shigella

49. Papillary CA of thyroid
drug that blocks purine synthesis and is metabolized by xanthine oxidase
optically clear nuclei (orphan annie)
thymidylate synthase
myelinates multiple CNS axons

50. Medulloblastoma
basal nucleus of Meynert
first line for absence seizures
P450 Inhibitors
homer wright rosettes