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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Hurlers
GM2 ganglioside accumulation
strawberry tongue
antibody against philadelphia chromosome
alpha L iduronidase

2. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
melanoma tumor marker
first line for cardiogenic shock
colchicine
alpha L iduronidase

3. Lymphoma

4. Gauchers
sulfonylureas side effect
cells destroyed in MS
Lewy bodies composition
most common lysosomal storage disease

5. Alpha synuclein
Lewy bodies composition
cells destroyed in Guillain Barre
child with eczema - coarse facial features - cold abscesses
x- linked recessive lysosomal storage diseases

6. TNF receptor
macrolides use (PUS)
cells destroyed in MS
etanercept
FGFR3 mutation

7. Flumazenil
papillary thyroid cancer
benzos antidote
oligodendrioglia
most common testicular tumor

8. 5- fluorouracil
thymidylate synthase
cancer associated with Hashimoto's thyroiditis
sumatriptan
What artery causes locked in syndrome

9. A/w esophageal/duodenal atresia and anencephaly
polyhydramnios
shown to slow progression of diabetic neuropathy
hallmark sign of COPD
bocks PRPP synthetase to block purine synthesis

10. Prevents incorporation into host DNA
locus ceruleus
keratin filled cysts
nucleoside reverse transcriptase inhibitors
deficiency of mannose phosphorylation

11. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
BCG PQRS
branching rods on oral infection
which nerve lifts the eyelid?
lisch nodules

12. Most common type of thyroid cancer
cause of malignant hyperthermia
papillary thyroid cancer
thymidylate synthase
enzyme used to conjugate bilirubin

13. Suspensory ligament of ovaries
chromosome 4
SE: facial flushing
most common breast mass in postmenopausal women
contains ovarian vessels

14. DiGeorge
epithelial
Where does the dorsal column decussate?
pt has extended expiratory phase
failure of endodermal development

15. Ovarian bengin tumor...looks like bladder
tumor with call - exner bodies
brenner tumor
von Hippel Lindau disease
glycine

16. Secretin
S cells
D cells
homer wright rosettes
most common testicular tumor

17. Trigeminal
what nerve innervates the muscles of mastication?
form multinucleated giant cells in the CNS when infected with HIV
protease inhibitors MofA
alpha 1 anti - trypsin

18. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
Lewy bodies composition
enzyme used to conjugate bilirubin
astrocytes
psammoma bodies

19. Clopidogrel - ticoplidine
UMN signs
mitral valve prolapse - liver diseae - berry aneurysm
sphingomyelinase deficiency
blocks ADP receptors to inhibit platelet aggregation

20. Medulla
inheritance pattern for all MENs
best effect on HDL
Lateral geniculate nucleus
Where does the dorsal column decussate?

21. Cell type involved in most ovarian tumors
LTB4
brenner tumor
Shigella
epithelial

22. Gauchers
ambiguous nucleus
branching rods on oral infection
MPTP exposure causes depletion of what NT?
crinkled paper cytoplasm

23. Alpha feto protein
antibody against philadelphia chromosome
Yolk sac tumor produces...
solitarius nucleus
master clock for circadian rhythms

24. Deficiency of aldosterone and cortisol

25. CCK
I cells
child with partial albinism - peripherial neuropathy - recurrent infections
smoking emphysema
adenomyosis

26. Glutamate
SICK PEG
3 tumors of MEN 1
resembles an onion in cross section
precursor to GABA

27. Small diameter > large diameter; myelinated > unmyelinated
myelinates on PNS
FGFR3 mutation
opioids antidote
order of nerve blockade

28. Sotalol - quinidine - cisapride
SE: torsades de pointes
ovarian tumor that resembles bladder epithelium
most common breast tumor in women under 25
brenner tumor

29. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
SICK PEG
astrocytes
dorsal motor nucleus
drug induced lupus

30. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
erythema nodosum
branching rods on oral infection
form multinucleated giant cells in the CNS when infected with HIV
complete mole components

31. Incomplete fusion of processus vaginalis
hydrocele
S cells
child with eczema - coarse facial features - cold abscesses
rate limiting step in carb digestion

32. Negri bodies
FGFR3 mutation
rabies
smoking emphysema
colchicine

33. Cause release of preformed insulin
thyroid cancer associtated with RET oncogene
what nerve innervates the muscles of mastication?
sulfonylureas
partial mole components

34. Medullary thyroid - pheochromocytoma - parathryoid
which nerve lifts the eyelid?
branching rods on oral infection
cause of increased myometrial excitability
3 tumors of MEN 2a

35. Oligosaccaride hydrolase
G cells
rate limiting step in carb digestion
benzos antidote
brain tumor with foamy cells and high vascularity

36. Niacin
cause of low pH vaginal discharge
What hormones share a common alpha subunit
SE: facial flushing
deficiency of mannose phosphorylation

37. Homocystienuria - Marfans
subluxation of lens
iduronidase sulfatase
hemangioblastomas of retina/cerebellum/medulla
lead antidote

38. Fibrates
SE: facial flushing
cause of low pH vaginal discharge
hydatidiform mole with crazy high hCG
best effect of triglycerides/VLDL

39. 2 sperm + 1 egg (fetal parts present)
child with partial albinism - peripherial neuropathy - recurrent infections
partial mole components
granulosa cell tumor secretes what?
chief cells

40. Hurlers
UMN signs
most common protozoal infection in US
adenomyosis
corneal clouding & MR

41. Brenners tumor
microglia
ovarian tumor that resembles bladder epithelium
chromosome 4
locus ceruleus

42. Demeclycocycline or water restriction
found in hairless skin
meissners
treatment for SIADH
erythema nodosum

43. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
drug induced lupus
glycine
tumor with call - exner bodies
hallmark sign of COPD

44. Actinomyces
oligohydramnios
infliximab
ventral posterior nucleus - medial part
branching rods on oral infection

45. TSH - LH - FSH - hCG
What hormones share a common alpha subunit
palisading nuclei - locally invasive
What causes coronary vasospasm as a SE?
Shigella

46. Decreases conversion
blocks ADP receptors to inhibit platelet aggregation
PTU
brain tumor with psammona bodies
What oncogene is a/w MEN 2a/b

47. Gauchers
S cells
beta glucocerebrosidase
locus ceruleus
cells destroyed in Guillain Barre

48. Medullary
Lateral geniculate nucleus
cancer arising from parafollicular C cells
rate limiting step in carb digestion
lead antidote

49. Estrogen (causes precocious puberty)
eczema/recurrent infections/thrombocytopenia
blood supply for thalamus
granulosa cell tumor secretes what?
sumatriptan

50. Chocolate agar
antibiotic with SE of eosinophilia
H. flu
dermatin sulfate accumulation
thymidylate synthase