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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. S-100
melanoma tumor marker
which nerve lifts the eyelid?
LMN signs
bocks PRPP synthetase to block purine synthesis

2. SICK PEG
most common arrthymia
drug induced lupus
P450 Inhibitors
intranuclear inclusions seen in herpes simplex encephalitis

3. Port wine stains - ipsilateral leptomeningeal angioma; can cause glaucoma - seizures - hemipareis - and MR
first line for absence seizures
Galactocerebrosidase deficiency
most common lysosomal storage disease
sturge weber syndrome

4. Hurlers
beta glucocerebrosidase
cancer arising from parafollicular C cells
corneal clouding & MR
copper - arsenic - gold antidote

5. B. fragilis
pt has extended expiratory phase
plenta accreta
most common bacteria in GI tract
ventral posterior nucleus - medial part

6. Motor
opioid withdrawal
may lead to multiple personalities
VA/VL
hydrocele

7. Glucuronyl transferase
intranuclear inclusions seen in herpes simplex encephalitis
LMN signs
enzyme used to conjugate bilirubin
solitarius nucleus

8. Job's or LAD
ovarian tumor that resembles bladder epithelium
neutrophils fail to respond to chemotaxic stimuli
vasculitis of infants and children - involving coronary arteries
tumor with call - exner bodies

9. Somatostatin
D cells
Abciximab
palisading nuclei - locally invasive
basal nucleus of Meynert

10. Choriocarcinoma or dysgerminoma
ovarian tumor with elevate hCG
adenomyosis
subluxation of lens
best effect on HDL

11. Memory
brain tumor with foamy cells and high vascularity
LTB4
chief cells
hippocampus

12. Cocain and sumatriptan
first line for cardiogenic shock
vasculitis a/w Hep B
locus ceruleus
What causes coronary vasospasm as a SE?

13. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
antibiotic with SE of eosinophilia
catalase positive coagulase negative
SICK PEG
sulfonylureas MofA

14. Naloxone/naltrexone
silver stain of gram negative rods
myelinates on PNS
opioids antidote
lewy body composition

15. 6- MP
hallmark sign of COPD
What are the hormone changes seen in menopause
drug that blocks purine synthesis and is metabolized by xanthine oxidase
G cells

16. Medulla
Where does the lateral corticospinal decussate?
copper - arsenic - gold antidote
opioids antidote
grossly black liver

17. Measles
most common testicular tumor
cough - conjunctivitis - coryza - fever
pacinian
What causes coronary vasospasm as a SE?

18. ADPKD
what nerve innervates the muscles of mastication?
most common first line agent for septic shock
inheritance pattern for all MENs
mitral valve prolapse - liver diseae - berry aneurysm

19. Membranous GN
paraventricular nucleus of hypothalamus
ovarian tumor with elevate hCG
spike and dome on microscope
sarcoma botyroides

20. Cell type involved in most ovarian tumors
plenta accreta
best effect on HDL
epithelial
chromosome 4

21. Increased acini and intralobular fibrosis
plenta accreta
catalase negative
sclerosing adenosis
blood supply for thalamus

22. Aminocaproic acid
drug that blocks purine synthesis and is metabolized by xanthine oxidase
strawberry tongue
t - PA - streptokinase antidote
I cells

23. Visual (Lateral for Light)
MofA Levothyroxine
optically clear nuclei (orphan annie)
Lateral geniculate nucleus
tumor composed of cytotrophoblasts and syncytiotrophoblasts

24. Membranoproliferative GN
GFAP positive
tram - track on microscope
3 tumors of MEN 1
child with partial albinism - peripherial neuropathy - recurrent infections

25. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
what checkpoint is p53 involved with?
brain tumor with psammona bodies
SICK PEG
ovarian tumor with psammoma bodies

26. Krabbe's
Galactocerebrosidase deficiency
LMN signs
corneal clouding & MR
child with partial albinism - peripherial neuropathy - recurrent infections

27. Actinomyces
branching rods on oral infection
rabies
basal nucleus of Meynert
diphtheria treatment

28. Protamine sulfate
defective tyrosine kinase
x- linked recessive lysosomal storage diseases
beta glucocerebrosidase
heparin antidote

29. Fibroadenoma
thyroid cancer associtated with RET oncogene
3 tumors of MEN 2a
most common breast tumor in women under 25
glycine

30. A/w esophageal/duodenal atresia and anencephaly
glycine
polyhydramnios
11 beta hydroxylase deficiency
oligohydramnios

31. Fabry's
brenner tumor
midshaft break of humerus
lysosomal storage disease a/w renal disease
LTB4

32. Hurlers - Hunters
Aschoff bodies
dermatin sulfate accumulation
antibody against philadelphia chromosome
sumatriptan

33. Basilar
partial mole components
What artery causes locked in syndrome
gram + bacteria that requires NAD and hemin for growth
protease inhibitors MofA

34. Intrinsic factor
tumor composed of cytotrophoblasts and syncytiotrophoblasts
tram - track on microscope
MofA Levothyroxine
parietal cells

35. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
order of nerve blockade
GABA - glutamine
LT C4 D4 E4
sturge weber syndrome

36. Hurlers
alpha L iduronidase
dose response curve change with competitive antagonist
HELLP syndrome
anti - epithelial antibodies

37. Rheumatic fever
Aschoff bodies
shown to slow progression of diabetic neuropathy
gram + bacteria that requires NAD and hemin for growth
opioid withdrawal

38. 3
most common lysosomal storage disease
defective tyrosine kinase
PGI2 (prostacyclin))
whats the V/Q at the apex of the lung

39. Impetigo
honey crusted lesions common around nose/lips
t - PA - streptokinase antidote
metformin side effect
hippocampus

40. Wiscott - Aldrich
spike and dome on microscope
raphe nucleus
dorsal motor nucleus
eczema/recurrent infections/thrombocytopenia

41. Neurofibromatosis
alpha 1 anti - trypsin
sclerosing adenosis
lisch nodules
vasculitis of infants and children - involving coronary arteries

42. NF 1
pigmented iris hamartomas - neural tumors
lysosomal storage disease - demyelinating disease
cells destroyed in MS
best effect of triglycerides/VLDL

43. Subacute (De Quervain's) thyroiditis
What thyroid pathology has an extremely tender thyroid gland
etanercept
heparin antidote
Conn's syndrome

44. Dissociative
may lead to multiple personalities
what checkpoint is p53 involved with?
beta glucocerebrosidase
kawasaki

45. Lymphoma

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46. Gauchers
silver stain of gram negative rods
most common testicular tumor in infants and children up to 3 years of age
eczema/recurrent infections/thrombocytopenia
crinkled paper cytoplasm

47. Basal cell carcinoma
polyhydramnios
kluver bucy
palisading nuclei - locally invasive
most common lysosomal storage disease

48. Dobutamine
SICK PEG
macrolides use (PUS)
mildly decreased UDPGT
first line for cardiogenic shock

49. Posterior communicating - posterior cerebral - anterior choroidal arteries
neutrophils fail to respond to chemotaxic stimuli
lewy body composition
blood supply for thalamus
MofA Levothyroxine

50. Alpha feto protein
deficiency of mannose phosphorylation
P450 Inhibitors
cells destroyed in Guillain Barre
Yolk sac tumor produces...