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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Hunters
iduronidase sulfatase
Conn's syndrome
FGFR3 mutation
most common testicular tumor

2. Gauchers
infliximab
beta glucocerebrosidase
PGI2 (prostacyclin))
sumatriptan

3. Glucuronyl transferase
5 alpha reductase deficiency
which nerve lifts the eyelid?
meissners
enzyme used to conjugate bilirubin

4. Yolk sac
SE: facial flushing
most common testicular tumor in infants and children up to 3 years of age
most common protozoal infection in US
silver stain of gram negative rods

5. Aminocaproic acid
alpha L iduronidase
Addison's
t - PA - streptokinase antidote
drug induced lupus

6. 0.6
antibody against philadelphia chromosome
bocks PRPP synthetase to block purine synthesis
whats the V/Q at the base of the lung
ovarian tumor with psammoma bodies

7. Membranous GN
may lead to multiple personalities
spike and dome on microscope
x- linked recessive lysosomal storage diseases
branching rods on oral infection

8. Normal or candida
cause of low pH vaginal discharge
antibiotic with SE of eosinophilia
most common protozoal infection in US
whats the V/Q at the apex of the lung

9. Hurlers
keratin filled cysts
cough - conjunctivitis - coryza - fever
alpha L iduronidase
placenta previa

10. Cocain and sumatriptan
Lateral geniculate nucleus
What causes coronary vasospasm as a SE?
ovarian tumor that resembles bladder epithelium
most common testicular tumor

11. Aplastic anemia - rash - agranulocytosis
11 beta hydroxylase deficiency
may lead to multiple personalities
brain tumor with fried egg appearance
propylthiouracil side effects

12. Medulla
D cells
catalase negative
What are the hormone changes seen in menopause
Where does the lateral corticospinal decussate?

13. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
treatment for SIADH
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
subluxation of lens
colchicine

14. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
What thyroid pathology has an extremely tender thyroid gland
most common bacteria in GI tract
LTB4
ventral posterior nucleus - medial part

15. PNH
PGI2 (prostacyclin))
enzyme used to conjugate bilirubin
granulosa cell tumor secretes what?
hemosiderinurea and thrombosis

16. NE
locus ceruleus
rate limiting step in carb digestion
most common first line agent for septic shock
anti - mitochondrial antibodies

17. Complete
found in hairless skin
hydatidiform mole with crazy high hCG
I cells
spike and dome on microscope

18. Combo of inhaled anesthetics & succinylcholine
abruptio placentae
branching rods on oral infection
antibody against philadelphia chromosome
cause of malignant hyperthermia

19. Benign - contains Reinke crystals - usually androgen producing
placenta previa
leydig cell tumor
anti - mitochondrial antibodies
drug that blocks purine synthesis and is metabolized by xanthine oxidase

20. Dobutamine
pseudopalisading necrosis
GM2 ganglioside accumulation
first line for cardiogenic shock
absent UTPGT

21. Achondroplasia
best effect of triglycerides/VLDL
FGFR3 mutation
cancer arising from parafollicular C cells
what cells secrete somatostatin

22. Hurlers
master clock for circadian rhythms
opioids antidote
absent UTPGT
corneal clouding & MR

23. Penicillamine
21 hydroxylase deficiency
tumor composed of cytotrophoblasts and syncytiotrophoblasts
dose response curve with noncompetitive antagonist
copper - arsenic - gold antidote

24. Tay SaX
LMN signs
heXosaminidase
brain tumor a/w von hipple - linadu syndrome
polyhydramnios

25. Membranoproliferative GN
tram - track on microscope
lysosomal storage disease - demyelinating disease
H. flu
Where does the spinothalamic decussate?

26. Demeclycocycline or water restriction
treatment for SIADH
3 tumors of MEN 2b
polyhydramnios
whats the V/Q at the apex of the lung

27. Visceral sensory
astrocytes
brain tumor a/w von hipple - linadu syndrome
solitarius nucleus
shown to slow progression of diabetic neuropathy

28. Inhibitory in the brain - stimulatory in the brain
brenner tumor
cancer arising from parafollicular C cells
blood supply for thalamus
GABA - glutamine

29. Schwann cells
21 hydroxylase deficiency
brain tumor with psammona bodies
cells destroyed in Guillain Barre
chief cells

30. ITP
thymidylate synthase
keratin filled cysts
subluxation of lens
anti - platelet antibodies

31. 2 sperm + 1 egg (fetal parts present)
most common arrthymia
kluver bucy
partial mole components
infliximab

32. Yolk sac tumor
best effect on HDL
placenta previa
solitarius nucleus
Schiller Duval bodies

33. Hairless skin - dynamic fine touch
which nerve lifts the eyelid?
anti - epithelial antibodies
meissners
What oncogene is a/w MEN 2a/b

34. Metachromatic leukodystrophy
lysosomal storage disease - demyelinating disease
MofA of N- aceylcysteine
opioids antidote
brain tumor with fried egg appearance

35. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
LT C4 D4 E4
5 alpha reductase deficiency
defective tyrosine kinase
hemangioblastomas of retina/cerebellum/medulla

36. Oligosaccaride hydrolase
mitral valve prolapse - liver diseae - berry aneurysm
rate limiting step in carb digestion
most common breast tumor in women under 25
beta glucocerebrosidase

37. Basilar
LMN signs
cause of malignant hyperthermia
x- linked recessive lysosomal storage diseases
What artery causes locked in syndrome

38. PNH
placenta previa
Conn's syndrome
hemosiderinurea + thrombosis
optically clear nuclei (orphan annie)

39. Oligodendrogila
what cells secrete somatostatin
Abciximab
cells destroyed in MS
21 hydroxylase deficiency

40. Criglar Najar
21 hydroxylase deficiency
GM2 ganglioside accumulation
absent UTPGT
Shigella

41. Attachment of placenta to lower uterine segment
sturge weber syndrome
placenta previa
cause of LH surge
brain tumor with psammona bodies

42. I- cell disease
protease inhibitors MofA
beta glucocerebrosidase
deficiency of mannose phosphorylation
schwann cells

43. Microglia
most common breast mass in postmenopausal women
dose response curve with noncompetitive antagonist
form multinucleated giant cells in the CNS when infected with HIV
D cells

44. ACE inhibitors
shown to slow progression of diabetic neuropathy
chief cells
catalase negative
most common arrthymia

45. Granulosa cell tumor
infliximab
abruptio placentae
tumor with call - exner bodies
SE: facial flushing

46. Fabry's
lysosomal storage disease a/w renal disease
brain tumor with fried egg appearance
Galactocerebrosidase deficiency
benzos antidote

47. Cell type involved in most ovarian tumors
ventral posterior nucleus - lateral part
branching rods on oral infection
may lead to multiple personalities
epithelial

48. Inhibits osteoclastic activity
brenner tumor
antibiotic with SE of eosinophilia
Bisphosphonates MofA
papillary thyroid cancer

49. Hypoglycemia
brenner tumor
sulfonylureas side effect
oligohydramnios
beta glucocerebrosidase

50. Papillary
mildly decreased UDPGT
thyroid cancer associtated with RET oncogene
drug induced lupus
blocks ADP receptors to inhibit platelet aggregation