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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. SCID
raphe nucleus
kluver bucy
thayer martin media
child with eczema - coarse facial features - cold abscesses

2. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
catalase positive coagulase negative
drug induced lupus
MofA of N- aceylcysteine
child with eczema - coarse facial features - cold abscesses

3. Parathyroid - pituitary - pancreatic
placenta previa
HELLP syndrome
BCG PQRS
3 tumors of MEN 1

4. Babinski - weakness - increased reflexes & tone - spastic paralysis
UMN signs
currant jelly stool
infliximab
astrocytes

5. Clopidogrel - ticoplidine
dose response curve change with competitive antagonist
blocks ADP receptors to inhibit platelet aggregation
sphingomyelinase deficiency
placenta previa

6. Yolk sac
brain tumor with psammona bodies
psammoma bodies
drug that blocks purine synthesis and is metabolized by xanthine oxidase
most common testicular tumor in infants and children up to 3 years of age

7. Niacin
basal nucleus of Meynert
SE: facial flushing
H. flu
inheritance pattern for all MENs

8. Decreased efficacy - decreased Vmax
vasculitis a/w Hep B
brenner tumor
dose response curve with noncompetitive antagonist
anti - mitochondrial antibodies

9. Estrogen
cause of increased myometrial excitability
brain tumor with perivascular pseudorosettes
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
myelinates on PNS

10. Penicillamine
preeclampsia
dose response curve change with competitive antagonist
copper - arsenic - gold antidote
drug that blocks purine synthesis and is metabolized by xanthine oxidase

11. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
thymidylate synthase
UMN signs
shown to slow progression of diabetic neuropathy
colchicine

12. Ovarian bengin tumor...looks like bladder
form multinucleated giant cells in the CNS when infected with HIV
I cells
sarcoma botyroides
brenner tumor

13. Papillary
myelinates multiple CNS axons
low dose ASA effects - intermediate dose - high dose
thyroid cancer associtated with RET oncogene
medial geniculate nucleus

14. Placenta attached to myometrium
plenta accreta
MofA of N- aceylcysteine
cause of low pH vaginal discharge
thymidylate synthase

15. Flumazenil
defective tyrosine kinase
thayer martin media
MPTP exposure causes depletion of what NT?
benzos antidote

16. A/w esophageal/duodenal atresia and anencephaly
grossly black liver
etanercept
polyhydramnios
dose response curve change with competitive antagonist

17. Amygdala
pseudopalisading necrosis
dorsal motor nucleus
kluver bucy
grossly black liver

18. Ethosuximide
most common breast mass in postmenopausal women
ovarian tumor with elevate hCG
first line for absence seizures
oligohydramnios

19. Damaged in multiple sclerosis
UMN signs
kawasaki
cause of LH surge
oligodendrioglia

20. Radial nerve - deep brachial artery
Conn's syndrome
psammoma bodies
midshaft break of humerus
GFAP positive

21. 6- MP
drug that blocks purine synthesis and is metabolized by xanthine oxidase
H. flu
TZD (glitazones) MofA
glycine

22. Visual (Lateral for Light)
pigmented iris hamartomas - neural tumors
increased MCHC and hemolytic anemia
Lateral geniculate nucleus
dermatin sulfate accumulation

23. Increased acini and intralobular fibrosis
sclerosing adenosis
raphe nucleus
iduronidase sulfatase
what checkpoint is p53 involved with?

24. Schwann cells
MofA Levothyroxine
copper - arsenic - gold antidote
epithelial
myelinates on PNS

25. Macrophages of the CNS
HELLP syndrome
FGFR3 mutation
microglia
schwann cells

26. Measles
P450 inducers
cough - conjunctivitis - coryza - fever
dermatin sulfate accumulation
basal nucleus of Meynert

27. Oligodendrogila
sarcoma botyroides
SE: torsades de pointes
hemosiderinurea + thrombosis
cells destroyed in MS

28. Hunters
iduronidase sulfatase
diphtheria treatment
hemosiderinurea + thrombosis
locus ceruleus

29. Job's or LAD
neutrophils fail to respond to chemotaxic stimuli
locus ceruleus
first line for cardiogenic shock
kluver bucy

30. Pacinian
ambiguous nucleus
t - PA - streptokinase antidote
Where does the lateral corticospinal decussate?
resembles an onion in cross section

31. Ach
hemosiderinurea + thrombosis
basal nucleus of Meynert
most common primary cardiac tumor in kiddos
iduronidase sulfatase

32. Trichomonas or bacterial vaginosis
homer wright rosettes
LT C4 D4 E4
ovarian tumor with elevate hCG
cause of high pH vaginal discharge

33. Autosomal dominant
papillary thyroid cancer
supraoptic nucleus of hypothalamus
cause of LH surge
inheritance pattern for all MENs

34. Gauchers
most common lysosomal storage disease
astrocytes
SICK PEG
parietal cells

35. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
astrocytes
what nerve innervates the muscles of mastication?
sulfonylureas
3 tumors of MEN 2b

36. Ach
fusion inhibitors
3 tumors of MEN 2a
currant jelly stool
basal nucleus of Meynert

37. Hereditary spherocytosis
increased MCHC and hemolytic anemia
Lewy bodies composition
gram + bacteria that requires NAD and hemin for growth
chromosome 4

38. Premature detachment of placenta - painful bleeding in 3rd trimester
abruptio placentae
whats the V/Q at the apex of the lung
21 hydroxylase deficiency
best effect on HDL

39. Alpha synuclein
Lewy bodies composition
hallmark sign of COPD
eczema/recurrent infections/thrombocytopenia
propylthiouracil side effects

40. Hemangioblastoma
colchicine
preeclampsia
brain tumor a/w von hipple - linadu syndrome
sulfonylureas MofA

41. Decreased potency - increased Km
cause of low pH vaginal discharge
branching rods on oral infection
dose response curve change with competitive antagonist
lysosomal storage disease a/w renal disease

42. Prazosin
what checkpoint is p53 involved with?
mildly decreased UDPGT
drug that blocks purine synthesis and is metabolized by xanthine oxidase
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

43. 5- fluorouracil
pacinian
brain tumor with fried egg appearance
thymidylate synthase
brain tumor a/w von hipple - linadu syndrome

44. Cavernous hemangiomas in skin - mucosa & organs; autosomal dominant - a/w renal CA - hemangioblastoma in retina - brainstem & cerebellum
von Hippel Lindau disease
sarcoma botyroides
order of nerve blockade
thymidylate synthase

45. Primary hyperaldosteronism (HTN - hypokalemia - metabolic alkalosis)

46. Lactic acidosis
rate limiting step in carb digestion
hydrocele
myelinates on PNS
metformin side effect

47. DiGeorge
Schiller Duval bodies
failure of endodermal development
GABA - glutamine
testicular tumor that can present with gynecomastia

48. Niemann Pick
HELLP syndrome
benzos antidote
MofA of N- aceylcysteine
sphingomyelinase deficiency

49. Deficiency of aldosterone and cortisol

50. Brenners tumor
LMN signs
ovarian tumor that resembles bladder epithelium
most common bacteria in GI tract
cough - conjunctivitis - coryza - fever