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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Inner lining of ventricles - make CSF - originate from neuroectoderm
silver stain of gram negative rods
ependymal cells
antibiotic with SE of eosinophilia
microglia

2. Wiscott - Aldrich
honey crusted lesions common around nose/lips
hemosiderinurea + thrombosis
ovarian tumor with psammoma bodies
eczema/recurrent infections/thrombocytopenia

3. Papillary CA of thyroid
keratin filled cysts
optically clear nuclei (orphan annie)
kluver bucy
cells destroyed in Guillain Barre

4. Oculomotor
sulfonylureas
granulosa cell tumor secretes what?
which nerve lifts the eyelid?
rate limiting step in carb digestion

5. Dantrolene (prevents release of calcium from SR of muscle)
treatment of malignant hyperthermia
silver stain of gram negative rods
adenomyosis
rate limiting step in carb digestion

6. Normal or candida
neutrophils fail to respond to chemotaxic stimuli
cause of low pH vaginal discharge
rate limiting step in carb digestion
Where does the dorsal column decussate?

7. Auditory (Medial for Music)
anti - platelet antibodies
cause of malignant hyperthermia
medial geniculate nucleus
plenta accreta

8. SCID
child with eczema - coarse facial features - cold abscesses
LT C4 D4 E4
alpha L iduronidase
drug that blocks purine synthesis and is metabolized by xanthine oxidase

9. Granulosa cell tumor
dose response curve with noncompetitive antagonist
treatment for SIADH
sumatriptan
tumor with call - exner bodies

10. B. fragilis
most common bacteria in GI tract
sclerosing adenosis
cause of low pH vaginal discharge
testicular tumor that can present with gynecomastia

11. Hemangioblastoma
brain tumor a/w von hipple - linadu syndrome
defective tyrosine kinase
Galactocerebrosidase deficiency
brain tumor with foamy cells and high vascularity

12. Hereditary spherocytosis
PTU
increased MCHC and hemolytic anemia
pacinian
UMN signs

13. Pneumonia - URIs - STDS
t - PA - streptokinase antidote
macrolides use (PUS)
branching rods on oral infection
deficiency of mannose phosphorylation

14. Trichomonas or bacterial vaginosis
ovarian tumor with psammoma bodies
anti - mitochondrial antibodies
oligohydramnios
cause of high pH vaginal discharge

15. Medullary
iduronidase sulfatase
LT C4 D4 E4
hemangioblastomas of retina/cerebellum/medulla
cancer arising from parafollicular C cells

16. Decreased FEV/FVC ratio
anti - mitochondrial antibodies
parietal cells
hallmark sign of COPD
precursor to GABA

17. 2 sperm + empty egg (no fetal parts)
meissners
neutrophils fail to respond to chemotaxic stimuli
complete mole components
partial mole components

18. Dissociative
myelinates multiple CNS axons
may lead to multiple personalities
hemangioblastomas of retina/cerebellum/medulla
most common breast tumor in women under 25

19. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
TZD (glitazones) MofA
precursor to GABA
grossly black liver
hallmark sign of COPD

20. Macrolides
medial geniculate nucleus
cells destroyed in MS
HELLP syndrome
antibiotic with SE of eosinophilia

21. Invasive ductal
sarcoma botyroides
What are the hormone changes seen in menopause
most common breast cancer
supraoptic nucleus of hypothalamus

22. Gastrin
G cells
absent UTPGT
What are the hormone changes seen in menopause
low dose ASA effects - intermediate dose - high dose

23. Hurlers
blocks ADP receptors to inhibit platelet aggregation
locus ceruleus
dose response curve change with competitive antagonist
alpha L iduronidase

24. Pacinian
Schiller Duval bodies
Abciximab
What are the hormone changes seen in menopause
resembles an onion in cross section

25. Norepinephrine
locus ceruleus
child with eczema - coarse facial features - cold abscesses
most common lysosomal storage disease
anti - mitochondrial antibodies

26. Invasive ductal CA
most common breast mass in postmenopausal women
locus ceruleus
antibiotic with SE of eosinophilia
plenta accreta

27. Gonorrhea
basal nucleus of Meynert
cause of low pH vaginal discharge
thayer martin media
sclerosing adenosis

28. Hunters
myelinates on PNS
pt has extended expiratory phase
11 beta hydroxylase deficiency
iduronidase sulfatase

29. Hurlers
Abciximab
first line for absence seizures
honey crusted lesions common around nose/lips
corneal clouding & MR

30. Kawasaki
vasculitis of infants and children - involving coronary arteries
grossly black liver
granulosa cell tumor secretes what?
GABA - glutamine

31. Suspensory ligament of ovaries
chief cells
contains ovarian vessels
nucleoside reverse transcriptase inhibitors
child with partial albinism - peripherial neuropathy - recurrent infections

32. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
macrolides use (PUS)
D cells
hemosiderinurea + thrombosis
kawasaki

33. Weakness - atrophy - fasiculations - decreased reflexes & tone
granulosa cell tumor secretes what?
eczema/recurrent infections/thrombocytopenia
LMN signs
defective tyrosine kinase

34. Ethosuximide
3 tumors of MEN 2a
cause of malignant hyperthermia
first line for absence seizures
What causes coronary vasospasm as a SE?

35. Serotonin
oligodendrioglia
raphe nucleus
H. flu
Where does the dorsal column decussate?

36. Inhibitory in the brain - stimulatory in the brain
GABA - glutamine
x- linked recessive lysosomal storage diseases
what inhibits prolactin secretion
most common testicular tumor

37. Meissner
colchicine
Schiller Duval bodies
found in hairless skin
BCG PQRS

38. Medulloblastoma
subluxation of lens
ovarian tumor with elevate hCG
leydig cell tumor
homer wright rosettes

39. Huntingtons chorea
preeclampsia
cancer associated with Hashimoto's thyroiditis
antibody against philadelphia chromosome
chromosome 4

40. ACE inhibitors
deficiency of mannose phosphorylation
increased MCHC and hemolytic anemia
shown to slow progression of diabetic neuropathy
sclerosing adenosis

41. Astrocytoma & glioblastoma multiforme
deficiency of mannose phosphorylation
lysosomal storage disease a/w renal disease
GFAP positive
what cells secrete somatostatin

42. Hemangioblastoma
pt has extended expiratory phase
contains ovarian vessels
brain tumor a/w von hipple - linadu syndrome
preeclampsia

43. Estrogen
lysosomal storage disease a/w renal disease
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
PTU
cause of increased myometrial excitability

44. Facial sensation (Make up on your face)
heparin antidote
ventral posterior nucleus - medial part
lysosomal storage disease a/w renal disease
chief cells

45. Niacins
Yolk sac tumor produces...
intranuclear inclusions seen in herpes simplex encephalitis
supraoptic nucleus of hypothalamus
best effect on HDL

46. Gauchers
preeclampsia
corneal clouding & MR
solitarius nucleus
crinkled paper cytoplasm

47. Oligodendrogila
cells destroyed in MS
HELLP syndrome
tram - track on microscope
FGFR3 mutation

48. Krabbe's
Galactocerebrosidase deficiency
Lewy bodies composition
alpha 1 anti - trypsin
What artery causes locked in syndrome

49. ADPKD
ovarian tumor with psammoma bodies
infliximab
Yolk sac tumor produces...
mitral valve prolapse - liver diseae - berry aneurysm

50. Schwann cells
cells destroyed in Guillain Barre
alpha galacosidase A
psammoma bodies
epithelial