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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Hunters
supraoptic nucleus of hypothalamus
H. flu
protease inhibitors MofA
iduronidase sulfatase

2. Dubin Johnson
21 hydroxylase deficiency
grossly black liver
best effect on HDL
brain tumor with perivascular pseudorosettes

3. 6- mecaptopurine (metabolized by xanthine oxidase)
MofA of N- aceylcysteine
contains ovarian vessels
hallmark sign of COPD
bocks PRPP synthetase to block purine synthesis

4. Hurlers
11 beta hydroxylase deficiency
corneal clouding & MR
pigmented iris hamartomas - neural tumors
cause of high pH vaginal discharge

5. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
thymidylate synthase
best effect on HDL
parietal cells
sulfonylureas MofA

6. Membranoproliferative GN
SICK PEG
myelinates on PNS
tram - track on microscope
increased MCHC and hemolytic anemia

7. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
nucleoside reverse transcriptase inhibitors
drug induced lupus
what cells secrete somatostatin
catalase negative

8. Fibrates
probenecid
best effect of triglycerides/VLDL
increased MCHC and hemolytic anemia
plenta accreta

9. Niemann Pick
sphingomyelinase deficiency
resembles an onion in cross section
parietal cells
ovarian tumor with psammoma bodies

10. Prevents incorporation into host DNA
nucleoside reverse transcriptase inhibitors
Bisphosphonates MofA
eczema/recurrent infections/thrombocytopenia
chief cells

11. Hemangioblastoma
contains ovarian vessels
brain tumor with foamy cells and high vascularity
silver stain of gram negative rods
hemangioblastomas of retina/cerebellum/medulla

12. Ovarian bengin tumor...looks like bladder
what checkpoint is p53 involved with?
failure of endodermal development
eczema/recurrent infections/thrombocytopenia
brenner tumor

13. CCK
I cells
failure of endodermal development
tram - track on microscope
treatment of malignant hyperthermia

14. Kawasaki
vasculitis of infants and children - involving coronary arteries
What are the hormone changes seen in menopause
dorsal motor nucleus
GABA - glutamine

15. Bruton's agammaglobulinemia
what cells secrete somatostatin
Aschoff bodies
fusion inhibitors
defective tyrosine kinase

16. Cavernous hemangiomas in skin - mucosa & organs; autosomal dominant - a/w renal CA - hemangioblastoma in retina - brainstem & cerebellum
MofA Levothyroxine
von Hippel Lindau disease
raphe nucleus
myelinates multiple CNS axons

17. Trigeminal
LT C4 D4 E4
what nerve innervates the muscles of mastication?
what cells secrete somatostatin
rabies

18. DiGeorge
crinkled paper cytoplasm
P450 inducers
VA/VL
failure of endodermal development

19. Norepinephrine
glycine
intranuclear inclusions seen in herpes simplex encephalitis
etanercept
locus ceruleus

20. BCG PQRS
tram - track on microscope
P450 inducers
hep B seropositivity in 30% of patients
sclerosing adenosis

21. B. fragilis
most common bacteria in GI tract
corneal clouding & MR
catalase positive coagulase negative
antibiotic with SE of eosinophilia

22. Second most common type of thyroid cancer
sarcoma botyroides
follicular
macrolides use (PUS)
most common gyno malignancy

23. Decreased efficacy - decreased Vmax
protease inhibitors MofA
tumor composed of cytotrophoblasts and syncytiotrophoblasts
most common bacteria in GI tract
dose response curve with noncompetitive antagonist

24. Panacinar
alpha 1 anti - trypsin
optically clear nuclei (orphan annie)
hep B seropositivity in 30% of patients
protease inhibitors MofA

25. Oligosaccaride hydrolase
contains ovarian vessels
oligodendrioglia
MofA Levothyroxine
rate limiting step in carb digestion

26. Lactic acidosis
propylthiouracil side effects
most common first line agent for septic shock
metformin side effect
best effect on HDL

27. Pneumonia - URIs - STDS
low dose ASA effects - intermediate dose - high dose
hemosiderinurea and thrombosis
resembles an onion in cross section
macrolides use (PUS)

28. Papillary
Where does the spinothalamic decussate?
barbituates withdrawal
thyroid cancer associtated with RET oncogene
brain tumor with foamy cells and high vascularity

29. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
3 tumors of MEN 2a
kawasaki
which nerve lifts the eyelid?
hallmark sign of COPD

30. Cant convert testosterone to DHT - ambiguous genitalia until puberty then penis at 12
5 alpha reductase deficiency
low dose ASA effects - intermediate dose - high dose
MofA of N- aceylcysteine
child with eczema - coarse facial features - cold abscesses

31. Flumazenil
schwann cells
colchicine
benzos antidote
anti - mitochondrial antibodies

32. Body sensation
ventral posterior nucleus - lateral part
palisading nuclei - locally invasive
11 beta hydroxylase deficiency
fusion inhibitors

33. Causes vasoconstriction (use for acute migraines)
sumatriptan
basal nucleus of Meynert
erythema nodosum
what meds treat malaria

34. Yolk sac
most common testicular tumor in infants and children up to 3 years of age
hallmark sign of COPD
adenomyosis
most common primary cardiac tumor in kiddos

35. Radial nerve - deep brachial artery
blood supply for thalamus
midshaft break of humerus
anti - mitochondrial antibodies
mitral valve prolapse - liver diseae - berry aneurysm

36. Kawasaki (treat with high dose aspirin)
meissners
strawberry tongue
antibiotic with SE of eosinophilia
Shigella

37. HTN; XY will be a girl - XX will lack secondary sex char.
infliximab
hydrocele
kawasaki
17 alpha hydroxylase deficiency

38. Centriacinar
P450 inducers
polyhydramnios
smoking emphysema
palisading nuclei - locally invasive

39. Babinski - weakness - increased reflexes & tone - spastic paralysis
ependymal cells
UMN signs
benzos antidote
strawberry tongue

40. Antibody binds to gp2b/3a - preventing aggregation
Abciximab
placenta previa
anti - mitochondrial antibodies
most common breast tumor in women under 25

41. Clopidogrel - ticoplidine
blocks ADP receptors to inhibit platelet aggregation
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
HELLP syndrome
TZD (glitazones) MofA

42. Decreases conversion
protease inhibitors MofA
PTU
parietal cells
midshaft break of humerus

43. Macrolides
hemosiderinurea and thrombosis
brain tumor with fried egg appearance
myelinates multiple CNS axons
antibiotic with SE of eosinophilia

44. Brenners tumor
what nerve innervates the muscles of mastication?
lysosomal storage disease - demyelinating disease
ovarian tumor that resembles bladder epithelium
chromosome 4

45. Schwann cells
myelinates on PNS
5 alpha reductase deficiency
dose response curve with noncompetitive antagonist
locus ceruleus

46. Gonorrhea
t - PA - streptokinase antidote
11 beta hydroxylase deficiency
anti - epithelial antibodies
thayer martin media

47. Hereditary spherocytosis
whats the V/Q at the apex of the lung
anti - platelet antibodies
antibiotic with SE of eosinophilia
increased MCHC and hemolytic anemia

48. Job's or LAD
vasculitis a/w Hep B
lisch nodules
cancer associated with Hashimoto's thyroiditis
neutrophils fail to respond to chemotaxic stimuli

49. Achondroplasia
branching rods on oral infection
myelinates on PNS
von Hippel Lindau disease
FGFR3 mutation

50. Dissociative
may lead to multiple personalities
brain tumor with psammona bodies
thromboxane A2
solitarius nucleus