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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Incomplete fusion of processus vaginalis
paraventricular nucleus of hypothalamus
GM2 ganglioside accumulation
catalase negative
hydrocele

2. Krabbe's
Bisphosphonates MofA
brenner tumor
alpha galacosidase A
Galactocerebrosidase deficiency

3. Leydig cell tumor
testicular tumor that can present with gynecomastia
papillary thyroid cancer
heparin antidote
pseudopalisading necrosis

4. I- cell disease
honey crusted lesions common around nose/lips
Addison's
deficiency of mannose phosphorylation
preeclampsia

5. Hurlers
thromboxane A2
alpha L iduronidase
metformin side effect
lysosomal storage disease a/w renal disease

6. Norepinephrine
cells destroyed in Guillain Barre
locus ceruleus
plenta accreta
basal nucleus of Meynert

7. ACE inhibitors
shown to slow progression of diabetic neuropathy
propylthiouracil side effects
LTB4
what nerve innervates the muscles of mastication?

8. Metachromatic leukodystrophy
keratin filled cysts
dorsal motor nucleus
lysosomal storage disease - demyelinating disease
heXosaminidase

9. Premature detachment of placenta - painful bleeding in 3rd trimester
optically clear nuclei (orphan annie)
abruptio placentae
basal nucleus of Meynert
raphe nucleus

10. Clopidogrel - ticoplidine
neutrophils fail to respond to chemotaxic stimuli
blocks ADP receptors to inhibit platelet aggregation
drug induced lupus
anti - mitochondrial antibodies

11. G1/S & G2/M
astrocytes
iduronidase sulfatase
I cells
what checkpoint is p53 involved with?

12. Antitoxin - penicillin - DPT vaccine
diphtheria treatment
MofA of N- aceylcysteine
protease inhibitors MofA
lewy body composition

13. Port wine stains - ipsilateral leptomeningeal angioma; can cause glaucoma - seizures - hemipareis - and MR
sclerosing adenosis
ependymal cells
sturge weber syndrome
PGI2 (prostacyclin))

14. A/w esophageal/duodenal atresia and anencephaly
subluxation of lens
increased MCHC and hemolytic anemia
cells destroyed in Guillain Barre
polyhydramnios

15. Weakness - atrophy - fasiculations - decreased reflexes & tone
SICK PEG
LMN signs
smoking emphysema
spike and dome on microscope

16. Fibrocystic
solitarius nucleus
What hormones share a common alpha subunit
What are the hormone changes seen in menopause
most common breast mass in pre - menopausal women

17. Intussception
currant jelly stool
lysosomal storage disease a/w renal disease
medial geniculate nucleus
propylthiouracil side effects

18. S-100
PGI2 (prostacyclin))
deficiency of mannose phosphorylation
melanoma tumor marker
3 tumors of MEN 1

19. Visual (Lateral for Light)
macrolides use (PUS)
GFAP positive
complete mole components
Lateral geniculate nucleus

20. Huntingtons chorea
chromosome 4
grossly black liver
lysosomal storage disease a/w renal disease
sclerosing adenosis

21. Chocolate agar
drug that blocks purine synthesis and is metabolized by xanthine oxidase
shown to slow progression of diabetic neuropathy
child with partial albinism - peripherial neuropathy - recurrent infections
H. flu

22. Streptococcus
catalase positive coagulase negative
hydatidiform mole with crazy high hCG
polyhydramnios
catalase negative

23. Dimercaprol
lead antidote
low dose ASA effects - intermediate dose - high dose
what inhibits prolactin secretion
benzos antidote

24. Lymphoma

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25. Imabtinib
strawberry tongue
lysosomal storage disease - demyelinating disease
antibody against philadelphia chromosome
microglia

26. Medullary
brain tumor with perivascular pseudorosettes
cancer arising from parafollicular C cells
GM2 ganglioside accumulation
x- linked recessive lysosomal storage diseases

27. Kawasaki
grossly black liver
myelinates multiple CNS axons
adenomyosis
vasculitis of infants and children - involving coronary arteries

28. Niemann Pick
nucleoside reverse transcriptase inhibitors
cause of low pH vaginal discharge
precursor to GABA
sphingomyelinase deficiency

29. Decreased efficacy - decreased Vmax
cells destroyed in Guillain Barre
blood supply for thalamus
dose response curve with noncompetitive antagonist
SE: elevated LFTS - myositis

30. Actinomyces
Aschoff bodies
P450 inducers
smoking emphysema
branching rods on oral infection

31. Visceral sensory
solitarius nucleus
pt has extended expiratory phase
cells destroyed in MS
ependymal cells

32. Gastrin
melanoma tumor marker
G cells
anti - epithelial antibodies
found in hairless skin

33. Endometrial glands inside myometrium
Abciximab
P450 inducers
drug induced lupus
adenomyosis

34. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
colchicine
ambiguous nucleus
drug induced lupus
eczema/recurrent infections/thrombocytopenia

35. Decreased follicles & estrogen with increased FSH & LH
What are the hormone changes seen in menopause
pt has extended expiratory phase
Lewy bodies composition
lysosomal storage disease - demyelinating disease

36. Posterior communicating - posterior cerebral - anterior choroidal arteries
rabies
cause of low pH vaginal discharge
What hormones share a common alpha subunit
blood supply for thalamus

37. Gauchers
thromboxane A2
chief cells
most common breast mass in postmenopausal women
beta glucocerebrosidase

38. Estrogen
cause of LH surge
currant jelly stool
cause of low pH vaginal discharge
ovarian tumor that resembles bladder epithelium

39. NE
locus ceruleus
strawberry tongue
oligohydramnios
most common gyno malignancy

40. Protamine sulfate
polyhydramnios
heparin antidote
macrolides use (PUS)
MofA Levothyroxine

41. Papillary
etanercept
thyroid cancer associtated with RET oncogene
VA/VL
What causes coronary vasospasm as a SE?

42. HTN; XY will be a girl - XX will lack secondary sex char.
lead antidote
Conn's syndrome
What are the hormone changes seen in menopause
17 alpha hydroxylase deficiency

43. Endometrial CA
hydatidiform mole with crazy high hCG
most common gyno malignancy
sulfonylureas
child with partial albinism - peripherial neuropathy - recurrent infections

44. HTN; masculinization
psammoma bodies
11 beta hydroxylase deficiency
UMN signs
hep B seropositivity in 30% of patients

45. Sotalol - quinidine - cisapride
glycine
most common primary cardiac tumor in kiddos
SE: torsades de pointes
medial geniculate nucleus

46. Invasive ductal CA
thymidylate synthase
which nerve lifts the eyelid?
most common breast mass in postmenopausal women
rabies

47. Glutamate
astrocytes
grossly black liver
S cells
precursor to GABA

48. HTN - proteinuria - edema
subluxation of lens
preeclampsia
H. flu
solitarius nucleus

49. Obstructive - COPD
Yolk sac tumor produces...
Abciximab
pt has extended expiratory phase
17 alpha hydroxylase deficiency

50. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
defective tyrosine kinase
sulfonylureas MofA
rabies
psammoma bodies