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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Posterior communicating - posterior cerebral - anterior choroidal arteries
blood supply for thalamus
epithelial
currant jelly stool
keratin filled cysts

2. Centriacinar
ovarian tumor with psammoma bodies
failure of endodermal development
smoking emphysema
thromboxane A2

3. Oligodendrioma
Abciximab
brain tumor with fried egg appearance
SE: facial flushing
infliximab

4. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
dose response curve change with competitive antagonist
SE: torsades de pointes
3 tumors of MEN 2b
catalase positive coagulase negative

5. A few levels above the level of entry
hallmark sign of COPD
ovarian tumor with psammoma bodies
grossly black liver
Where does the spinothalamic decussate?

6. Cell type involved in most ovarian tumors
pigmented iris hamartomas - neural tumors
Addison's
epithelial
3 tumors of MEN 2b

7. S-100
melanoma tumor marker
etanercept
chief cells
gram + bacteria that requires NAD and hemin for growth

8. Tay SaX
heXosaminidase
What causes coronary vasospasm as a SE?
epithelial
anti - mitochondrial antibodies

9. Rheumatic fever
What thyroid pathology has an extremely tender thyroid gland
Aschoff bodies
best effect on HDL
honey crusted lesions common around nose/lips

10. Intrinsic factor
parietal cells
vasculitis a/w Hep B
solitarius nucleus
basal nucleus of Meynert

11. Invasive ductal CA
treatment for SIADH
Where does the dorsal column decussate?
most common breast mass in postmenopausal women
astrocytes

12. Schwann cells
cells destroyed in Guillain Barre
thromboxane A2
honey crusted lesions common around nose/lips
infliximab

13. Niemann Pick
FGFR3 mutation
palisading nuclei - locally invasive
sphingomyelinase deficiency
UMN signs

14. Oculomotor
dorsal motor nucleus
which nerve lifts the eyelid?
enzyme used to conjugate bilirubin
locus ceruleus

15. ADPKD
mitral valve prolapse - liver diseae - berry aneurysm
opioids antidote
cause of low pH vaginal discharge
sulfonylureas side effect

16. Decreased FEV/FVC ratio
thymidylate synthase
hallmark sign of COPD
opioid withdrawal
cause of high pH vaginal discharge

17. Naloxone/naltrexone
17 alpha hydroxylase deficiency
G cells
lead antidote
opioids antidote

18. Staph epidermidis - staph sapro
most common arrthymia
spike and dome on microscope
catalase positive coagulase negative
G cells

19. Secretin
S cells
locus ceruleus
SE: torsades de pointes
GFAP positive

20. Streptococcus
dose response curve with noncompetitive antagonist
follicular
catalase negative
best effect on HDL

21. Job's or LAD
FGFR3 mutation
first line for absence seizures
lewy body composition
neutrophils fail to respond to chemotaxic stimuli

22. Dissociative
hemangioblastomas of retina/cerebellum/medulla
anti - platelet antibodies
may lead to multiple personalities
plenta accreta

23. Prazosin
deficiency of mannose phosphorylation
D cells
preeclampsia
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

24. ITP
anti - platelet antibodies
What thyroid pathology has an extremely tender thyroid gland
basal nucleus of Meynert
ventral posterior nucleus - lateral part

25. Macconkey's agar
leydig cell tumor
Shigella
dose response curve change with competitive antagonist
currant jelly stool

26. Subacute (De Quervain's) thyroiditis
5 alpha reductase deficiency
cause of low pH vaginal discharge
What thyroid pathology has an extremely tender thyroid gland
ambiguous nucleus

27. Hereditary spherocytosis
ependymal cells
etanercept
contains ovarian vessels
increased MCHC and hemolytic anemia

28. 2 sperm + empty egg (no fetal parts)
catalase positive coagulase negative
complete mole components
testicular tumor that can present with gynecomastia
cause of increased myometrial excitability

29. Actinomyces
branching rods on oral infection
sulfonylureas side effect
parietal cells
rabies

30. Fabry's
optically clear nuclei (orphan annie)
lysosomal storage disease a/w renal disease
sclerosing adenosis
probenecid

31. TSH - LH - FSH - hCG
gram + bacteria that requires NAD and hemin for growth
G cells
What hormones share a common alpha subunit
what inhibits prolactin secretion

32. Granulosa cell tumor
subluxation of lens
most common gyno malignancy
tumor with call - exner bodies
Galactocerebrosidase deficiency

33. Estrogen (causes precocious puberty)
looks like fried eggs under histologic staining
basal nucleus of Meynert
BCG PQRS
granulosa cell tumor secretes what?

34. Gauchers
crinkled paper cytoplasm
probenecid
Lateral geniculate nucleus
hemosiderinurea + thrombosis

35. Hemangioblastoma
GABA - glutamine
brain tumor with psammona bodies
whats the V/Q at the base of the lung
brain tumor with foamy cells and high vascularity

36. Tay Sachs
GM2 ganglioside accumulation
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
TZD (glitazones) MofA
lisch nodules

37. I- cell disease
anti - platelet antibodies
deficiency of mannose phosphorylation
fusion inhibitors
gram + bacteria that requires NAD and hemin for growth

38. B. fragilis
most common bacteria in GI tract
what inhibits prolactin secretion
most common protozoal infection in US
mitral valve prolapse - liver diseae - berry aneurysm

39. Makes ADH
What oncogene is a/w MEN 2a/b
supraoptic nucleus of hypothalamus
macrolides use (PUS)
sulfonylureas

40. Ach
basal nucleus of Meynert
t - PA - streptokinase antidote
heparin antidote
x- linked recessive lysosomal storage diseases

41. TNF receptor
P450 inducers
etanercept
dose response curve with noncompetitive antagonist
currant jelly stool

42. Choriocarcinoma
polyhydramnios
tumor composed of cytotrophoblasts and syncytiotrophoblasts
17 alpha hydroxylase deficiency
D cells

43. Glutamate
precursor to GABA
strawberry tongue
opioids antidote
whats the V/Q at the apex of the lung

44. Attachment of placenta to lower uterine segment
heparin antidote
eczema/recurrent infections/thrombocytopenia
adenomyosis
placenta previa

45. NF 1
pigmented iris hamartomas - neural tumors
lead antidote
Schiller Duval bodies
GABA - glutamine

46. Inhibitory in the brain - stimulatory in the brain
grossly black liver
antibiotic with SE of eosinophilia
GABA - glutamine
myelinates multiple CNS axons

47. Pneumonia - URIs - STDS
x- linked recessive lysosomal storage diseases
macrolides use (PUS)
palisading nuclei - locally invasive
whats the V/Q at the base of the lung

48. Hurlers
chief cells
keratin filled cysts
partial mole components
alpha L iduronidase

49. Primary biliary cirrhosis
myelinates multiple CNS axons
colchicine
anti - mitochondrial antibodies
intranuclear inclusions seen in herpes simplex encephalitis

50. Gastrin
MPTP exposure causes depletion of what NT?
propylthiouracil side effects
most common breast cancer
G cells