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USMLE Pathophys

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. Astrocytoma & glioblastoma multiforme
Lewy bodies composition
form multinucleated giant cells in the CNS when infected with HIV
GFAP positive
thymidylate synthase

2. 6- mecaptopurine (metabolized by xanthine oxidase)
MPTP exposure causes depletion of what NT?
bocks PRPP synthetase to block purine synthesis
probenecid
crinkled paper cytoplasm

3. Placenta attached to myometrium
GM2 ganglioside accumulation
astrocytes
ovarian tumor with psammoma bodies
plenta accreta

4. Antibody binds to gp2b/3a - preventing aggregation
Abciximab
cells destroyed in MS
What are the hormone changes seen in menopause
BCG PQRS

5. H. Influenza
gram + bacteria that requires NAD and hemin for growth
21 hydroxylase deficiency
most common lysosomal storage disease
keratin filled cysts

6. Cells of BBB
what nerve innervates the muscles of mastication?
complete mole components
opioid withdrawal
astrocytes

7. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
benzos antidote
propylthiouracil side effects
opioid withdrawal
keratin filled cysts

8. Primary biliary cirrhosis
MofA of N- aceylcysteine
anti - mitochondrial antibodies
smoking emphysema
form multinucleated giant cells in the CNS when infected with HIV

9. Cell type involved in most ovarian tumors
epithelial
myelinates multiple CNS axons
thymidylate synthase
microglia

10. Bruton's agammaglobulinemia
defective tyrosine kinase
grossly black liver
sphingomyelinase deficiency
UMN signs

11. Ach
basal nucleus of Meynert
smoking emphysema
adenomyosis
precursor to GABA

12. Lactic acidosis
metformin side effect
vasculitis a/w Hep B
lisch nodules
first line for absence seizures

13. ADPKD
S cells
mitral valve prolapse - liver diseae - berry aneurysm
low dose ASA effects - intermediate dose - high dose
What thyroid pathology has an extremely tender thyroid gland

14. Measles
what cells secrete somatostatin
what checkpoint is p53 involved with?
cough - conjunctivitis - coryza - fever
silver stain of gram negative rods

15. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
psammoma bodies
drug induced lupus
sclerosing adenosis
medial geniculate nucleus

16. Pneumonia - URIs - STDS
MofA Levothyroxine
vasculitis a/w Hep B
tumor with call - exner bodies
macrolides use (PUS)

17. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
leydig cell tumor
propylthiouracil side effects
colchicine
paraventricular nucleus of hypothalamus

18. Dobutamine
alpha 1 anti - trypsin
SE: facial flushing
chief cells
first line for cardiogenic shock

19. Homocystienuria - Marfans
subluxation of lens
What hormones share a common alpha subunit
pseudopalisading necrosis
alpha L iduronidase

20. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
What are the hormone changes seen in menopause
blood supply for thalamus
x- linked recessive lysosomal storage diseases
kawasaki

21. Marfans
basal nucleus of Meynert
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
What are the hormone changes seen in menopause
most common breast tumor in women under 25

22. Choriocarcinoma
tumor composed of cytotrophoblasts and syncytiotrophoblasts
pt has extended expiratory phase
Abciximab
lewy body composition

23. Subacute (De Quervain's) thyroiditis
21 hydroxylase deficiency
branching rods on oral infection
sulfonylureas
What thyroid pathology has an extremely tender thyroid gland

24. Causes vasoconstriction (use for acute migraines)
catalase positive coagulase negative
what checkpoint is p53 involved with?
sumatriptan
5 alpha reductase deficiency

25. Posterior communicating - posterior cerebral - anterior choroidal arteries
medial geniculate nucleus
blood supply for thalamus
raphe nucleus
thayer martin media

26. Parathyroid - pituitary - pancreatic
3 tumors of MEN 1
UMN signs
brain tumor with perivascular pseudorosettes
smoking emphysema

27. Gilberts
17 alpha hydroxylase deficiency
mildly decreased UDPGT
thayer martin media
mitral valve prolapse - liver diseae - berry aneurysm

28. Invasive ductal
strawberry tongue
most common breast cancer
macrolides use (PUS)
sulfonylureas

29. I- cell disease
MofA Levothyroxine
eczema/recurrent infections/thrombocytopenia
rate limiting step in carb digestion
deficiency of mannose phosphorylation

30. Inhibits osteoclastic activity
Bisphosphonates MofA
mildly decreased UDPGT
cancer associated with Hashimoto's thyroiditis
heXosaminidase

31. Suspensory ligament of ovaries
contains ovarian vessels
adenomyosis
dose response curve change with competitive antagonist
cancer associated with Hashimoto's thyroiditis

32. Kawasaki
grossly black liver
hemosiderinurea + thrombosis
sulfonylureas
vasculitis of infants and children - involving coronary arteries

33. Alpha feto protein
Yolk sac tumor produces...
17 alpha hydroxylase deficiency
currant jelly stool
what cells secrete somatostatin

34. Chloroquine and primaquine
what meds treat malaria
HELLP syndrome
thayer martin media
basal nucleus of Meynert

35. Amygdala
alpha 1 anti - trypsin
abruptio placentae
kluver bucy
oligodendrioglia

36. Macrophages of the CNS
rabies
G cells
microglia
heparin antidote

37. Fabry's & Hunters
TZD (glitazones) MofA
first line for absence seizures
basal nucleus of Meynert
x- linked recessive lysosomal storage diseases

38. Actinomyces
BCG PQRS
What hormones share a common alpha subunit
vasculitis of infants and children - involving coronary arteries
branching rods on oral infection

39. Protamine sulfate
mitral valve prolapse - liver diseae - berry aneurysm
heparin antidote
leydig cell tumor
psammoma bodies

40. ACE inhibitors
most common breast mass in pre - menopausal women
shown to slow progression of diabetic neuropathy
anti - mitochondrial antibodies
barbituates withdrawal

41. Most common type of thyroid cancer
What are the hormone changes seen in menopause
first line for cardiogenic shock
sumatriptan
papillary thyroid cancer

42. Complete
hydatidiform mole with crazy high hCG
whats the V/Q at the base of the lung
Shigella
master clock for circadian rhythms

43. Chronic gout. inhibits reabsorbtion of uric acid in PCT
melanoma tumor marker
shown to slow progression of diabetic neuropathy
probenecid
kluver bucy

44. Brenners tumor
ovarian tumor that resembles bladder epithelium
what checkpoint is p53 involved with?
FGFR3 mutation
abruptio placentae

45. B. fragilis
best effect of triglycerides/VLDL
copper - arsenic - gold antidote
most common bacteria in GI tract
SE: elevated LFTS - myositis

46. Somatostatin
treatment of malignant hyperthermia
blood supply for thalamus
D cells
cause of low pH vaginal discharge

47. Yolk sac
What are the hormone changes seen in menopause
most common testicular tumor in infants and children up to 3 years of age
meissners
lisch nodules

48. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
first line for absence seizures
Where does the lateral corticospinal decussate?
TZD (glitazones) MofA
MPTP exposure causes depletion of what NT?

49. Microglia
von Hippel Lindau disease
resembles an onion in cross section
form multinucleated giant cells in the CNS when infected with HIV
P450 inducers

50. Penicillamine
hallmark sign of COPD
found in hairless skin
strawberry tongue
copper - arsenic - gold antidote

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USMLE Pathophys

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