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USMLE Pathophys

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Yolk sac
Yolk sac tumor produces...
cancer arising from parafollicular C cells
most common testicular tumor in infants and children up to 3 years of age
erythema nodosum

2. Metachromatic leukodystrophy
mildly decreased UDPGT
lisch nodules
lysosomal storage disease - demyelinating disease
most common lysosomal storage disease

3. Premature detachment of placenta - painful bleeding in 3rd trimester
hemangioblastomas of retina/cerebellum/medulla
whats the V/Q at the base of the lung
whats the V/Q at the apex of the lung
abruptio placentae

4. Hunters
child with eczema - coarse facial features - cold abscesses
solitarius nucleus
Abciximab
iduronidase sulfatase

5. Antibody binds to gp2b/3a - preventing aggregation
dermatin sulfate accumulation
astrocytes
sulfonylureas
Abciximab

6. Combo of inhaled anesthetics & succinylcholine
brain tumor a/w von hipple - linadu syndrome
cause of malignant hyperthermia
tumor with call - exner bodies
von Hippel Lindau disease

7. Oligosaccaride hydrolase
rate limiting step in carb digestion
myelinates on PNS
hemosiderinurea and thrombosis
basal nucleus of Meynert

8. Medullary thyroid - pheochromocytoma - parathryoid
3 tumors of MEN 2a
anti - platelet antibodies
epithelial
resembles an onion in cross section

9. Sends autonomic fibers to heart
LTB4
smoking emphysema
dorsal motor nucleus
hippocampus

10. Pemphigus vulgaris
anti - epithelial antibodies
spike and dome on microscope
Aschoff bodies
11 beta hydroxylase deficiency

11. Penicillamine
contains ovarian vessels
heXosaminidase
leydig cell tumor
copper - arsenic - gold antidote

12. G1/S & G2/M
most common testicular tumor
diphtheria treatment
most common bacteria in GI tract
what checkpoint is p53 involved with?

13. Decreases conversion
sarcoma botyroides
propylthiouracil side effects
nucleoside reverse transcriptase inhibitors
PTU

14. Trichomonas - Giardia
Where does the spinothalamic decussate?
precursor to GABA
most common protozoal infection in US
basal nucleus of Meynert

15. Basal cell carcinoma
most common breast mass in postmenopausal women
looks like fried eggs under histologic staining
palisading nuclei - locally invasive
What hormones share a common alpha subunit

16. Glutamate
hydatidiform mole with crazy high hCG
precursor to GABA
What hormones share a common alpha subunit
barbituates withdrawal

17. Glioblastoma multiforme
pseudopalisading necrosis
vasculitis of infants and children - involving coronary arteries
copper - arsenic - gold antidote
subluxation of lens

18. Dissociative
may lead to multiple personalities
Abciximab
FGFR3 mutation
cancer associated with Hashimoto's thyroiditis

19. Alpha synuclein
most common arrthymia
UMN signs
Lewy bodies composition
mildly decreased UDPGT

20. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
follicular
abruptio placentae
tumor with call - exner bodies
drug induced lupus

21. Gauchers
crinkled paper cytoplasm
lysosomal storage disease - demyelinating disease
microglia
Conn's syndrome

22. Bilateral renal agenesis or posterior urethral valves in males
alpha 1 anti - trypsin
papillary thyroid cancer
oligohydramnios
catalase negative

23. Hurlers
Addison's
alpha L iduronidase
deficiency of mannose phosphorylation
corneal clouding & MR

24. Dopamine
lead antidote
child with partial albinism - peripherial neuropathy - recurrent infections
MPTP exposure causes depletion of what NT?
beta glucocerebrosidase

25. Niacin
SE: facial flushing
found in hairless skin
cells destroyed in MS
etanercept

26. Cell type involved in most ovarian tumors
epithelial
thayer martin media
intranuclear inclusions seen in herpes simplex encephalitis
meissners

27. Panacinar
alpha 1 anti - trypsin
What causes coronary vasospasm as a SE?
MofA Levothyroxine
master clock for circadian rhythms

28. Kawasaki
abruptio placentae
vasculitis of infants and children - involving coronary arteries
sulfonylureas MofA
what cells secrete somatostatin

29. Huntingtons chorea
opioid withdrawal
microglia
chromosome 4
paraventricular nucleus of hypothalamus

30. Somatostatin
astrocytes
D cells
grossly black liver
catalase positive coagulase negative

31. Seminoma
most common testicular tumor
thayer martin media
cough - conjunctivitis - coryza - fever
FGFR3 mutation

32. Alpha feto protein
adenomyosis
Yolk sac tumor produces...
deficiency of mannose phosphorylation
polyhydramnios

33. Papillary CA of thyroid
hydrocele
ovarian tumor with elevate hCG
optically clear nuclei (orphan annie)
lead antidote

34. Inhibitory in the SC
glycine
branching rods on oral infection
alpha L iduronidase
most common protozoal infection in US

35. Prevents incorporation into host DNA
nucleoside reverse transcriptase inhibitors
What causes coronary vasospasm as a SE?
What are the hormone changes seen in menopause
UMN signs

36. Trigeminal
paraventricular nucleus of hypothalamus
macrolides use (PUS)
what nerve innervates the muscles of mastication?
21 hydroxylase deficiency

37. Estrogen
cells destroyed in MS
ovarian tumor with psammoma bodies
what checkpoint is p53 involved with?
cause of increased myometrial excitability

38. Schwann cells
myelinates on PNS
treatment for SIADH
SE: elevated LFTS - myositis
failure of endodermal development

39. Endometrial glands inside myometrium
solitarius nucleus
adenomyosis
deficiency of mannose phosphorylation
eczema/recurrent infections/thrombocytopenia

40. Kawasaki (treat with high dose aspirin)
PTU
what checkpoint is p53 involved with?
alpha 1 anti - trypsin
strawberry tongue

41. Estrogen
cause of LH surge
looks like fried eggs under histologic staining
bocks PRPP synthetase to block purine synthesis
hallmark sign of COPD

42. Clopidogrel - ticoplidine
thayer martin media
precursor to GABA
blocks ADP receptors to inhibit platelet aggregation
corneal clouding & MR

43. Oligodendrogila
cells destroyed in MS
silver stain of gram negative rods
hydrocele
cancer arising from parafollicular C cells

44. Brenners tumor
resembles an onion in cross section
brain tumor with perivascular pseudorosettes
crinkled paper cytoplasm
ovarian tumor that resembles bladder epithelium

45. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
drug that blocks purine synthesis and is metabolized by xanthine oxidase
brain tumor with foamy cells and high vascularity
most common primary cardiac tumor in kiddos
erythema nodosum

46. 6- mecaptopurine (metabolized by xanthine oxidase)
hep B seropositivity in 30% of patients
what inhibits prolactin secretion
bocks PRPP synthetase to block purine synthesis
parietal cells

47. Inner lining of ventricles - make CSF - originate from neuroectoderm
UMN signs
what nerve innervates the muscles of mastication?
antibody against philadelphia chromosome
ependymal cells

48. Inhibitory in the brain - stimulatory in the brain
GABA - glutamine
most common protozoal infection in US
3 tumors of MEN 2b
child with partial albinism - peripherial neuropathy - recurrent infections

49. Second most common type of thyroid cancer
chromosome 4
follicular
crinkled paper cytoplasm
most common gyno malignancy

50. Choriocarcinoma or dysgerminoma
heXosaminidase
currant jelly stool
ovarian tumor with elevate hCG
P450 inducers

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USMLE Pathophys

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