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USMLE Pathophys

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Macrophages of the CNS
brain tumor with foamy cells and high vascularity
cause of low pH vaginal discharge
microglia
astrocytes

2. Microglia
form multinucleated giant cells in the CNS when infected with HIV
which nerve lifts the eyelid?
Conn's syndrome
deficiency of mannose phosphorylation

3. NE
first line for absence seizures
mitral valve prolapse - liver diseae - berry aneurysm
locus ceruleus
epithelial

4. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
PTU
SE: torsades de pointes
sulfonylureas MofA
sarcoma botyroides

5. Inner lining of ventricles - make CSF - originate from neuroectoderm
5 alpha reductase deficiency
Addison's
ependymal cells
order of nerve blockade

6. Fabry's
solitarius nucleus
lysosomal storage disease a/w renal disease
opioids antidote
best effect on HDL

7. Visceral sensory
dermatin sulfate accumulation
granulosa cell tumor secretes what?
most common testicular tumor in infants and children up to 3 years of age
solitarius nucleus

8. Gauchers
colchicine
crinkled paper cytoplasm
17 alpha hydroxylase deficiency
3 tumors of MEN 1

9. Wiscott - Aldrich
eczema/recurrent infections/thrombocytopenia
smoking emphysema
child with partial albinism - peripherial neuropathy - recurrent infections
5 alpha reductase deficiency

10. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
branching rods on oral infection
paraventricular nucleus of hypothalamus
oligohydramnios
psammoma bodies

11. Hurlers - Hunters
brain tumor with fried egg appearance
preeclampsia
dermatin sulfate accumulation
3 tumors of MEN 2a

12. Meningioma
alpha galacosidase A
found in hairless skin
diphtheria treatment
brain tumor with psammona bodies

13. Secretin
S cells
most common gyno malignancy
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
tumor with call - exner bodies

14. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
cause of malignant hyperthermia
LT C4 D4 E4
pt has extended expiratory phase
master clock for circadian rhythms

15. Babinski - weakness - increased reflexes & tone - spastic paralysis
meissners
ovarian tumor with psammoma bodies
oligodendrioglia
UMN signs

16. Chloroquine and primaquine
t - PA - streptokinase antidote
hemangioblastomas of retina/cerebellum/medulla
opioids antidote
what meds treat malaria

17. Cell type involved in most ovarian tumors
epithelial
oligodendrioglia
hemangioblastomas of retina/cerebellum/medulla
copper - arsenic - gold antidote

18. Decreased efficacy - decreased Vmax
rate limiting step in carb digestion
complete mole components
dose response curve with noncompetitive antagonist
mitral valve prolapse - liver diseae - berry aneurysm

19. I- cell disease
iduronidase sulfatase
currant jelly stool
deficiency of mannose phosphorylation
fusion inhibitors

20. Inhibits osteoclastic activity
MPTP exposure causes depletion of what NT?
Bisphosphonates MofA
spike and dome on microscope
What causes coronary vasospasm as a SE?

21. Centriacinar
smoking emphysema
melanoma tumor marker
which nerve lifts the eyelid?
opioid withdrawal

22. Hunters
hydatidiform mole with crazy high hCG
sulfonylureas
order of nerve blockade
iduronidase sulfatase

23. Dissociative
cause of LH surge
most common first line agent for septic shock
ovarian tumor with psammoma bodies
may lead to multiple personalities

24. Prevents incorporation into host DNA
What hormones share a common alpha subunit
inheritance pattern for all MENs
nucleoside reverse transcriptase inhibitors
brain tumor with foamy cells and high vascularity

25. S-100
chromosome 4
melanoma tumor marker
PTU
supraoptic nucleus of hypothalamus

26. Atrial fibrillation
most common arrthymia
optically clear nuclei (orphan annie)
what checkpoint is p53 involved with?
protease inhibitors MofA

27. A/w esophageal/duodenal atresia and anencephaly
pseudopalisading necrosis
polyhydramnios
dorsal motor nucleus
crinkled paper cytoplasm

28. 6- MP
drug that blocks purine synthesis and is metabolized by xanthine oxidase
MPTP exposure causes depletion of what NT?
which nerve lifts the eyelid?
form multinucleated giant cells in the CNS when infected with HIV

29. Posterior communicating - posterior cerebral - anterior choroidal arteries
blood supply for thalamus
hep B seropositivity in 30% of patients
testicular tumor that can present with gynecomastia
astrocytes

30. Hypoglycemia
intranuclear inclusions seen in herpes simplex encephalitis
sulfonylureas side effect
von Hippel Lindau disease
melanoma tumor marker

31. Memory
hippocampus
brain tumor a/w von hipple - linadu syndrome
papillary thyroid cancer
Aschoff bodies

32. Medulloblastoma
schwann cells
most common arrthymia
sclerosing adenosis
homer wright rosettes

33. Serotonin
raphe nucleus
21 hydroxylase deficiency
astrocytes
LTB4

34. HTN - proteinuria - edema
preeclampsia
form multinucleated giant cells in the CNS when infected with HIV
thymidylate synthase
medial geniculate nucleus

35. Hemangioblastoma
corneal clouding & MR
brain tumor a/w von hipple - linadu syndrome
schwann cells
5 alpha reductase deficiency

36. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
cancer arising from parafollicular C cells
increased MCHC and hemolytic anemia
sulfonylureas MofA
anti - mitochondrial antibodies

37. Estrogen
Conn's syndrome
complete mole components
chromosome 4
cause of increased myometrial excitability

38. Papillary
mildly decreased UDPGT
thyroid cancer associtated with RET oncogene
currant jelly stool
parietal cells

39. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
colchicine
lead antidote
currant jelly stool
crinkled paper cytoplasm

40. Chronic gout. inhibits reabsorbtion of uric acid in PCT
probenecid
follicular
MofA Levothyroxine
glycine

41. NF 1
FGFR3 mutation
pigmented iris hamartomas - neural tumors
treatment for SIADH
heparin antidote

42. Obstructive - COPD
kluver bucy
crinkled paper cytoplasm
Yolk sac tumor produces...
pt has extended expiratory phase

43. Lactic acidosis
17 alpha hydroxylase deficiency
colchicine
metformin side effect
grossly black liver

44. Demeclycocycline or water restriction
what cells secrete somatostatin
treatment for SIADH
Addison's
lewy body composition

45. Fabry's & Hunters
GABA - glutamine
most common primary cardiac tumor in kiddos
x- linked recessive lysosomal storage diseases
3 tumors of MEN 2b

46. Dimercaprol
psammoma bodies
lead antidote
SE: elevated LFTS - myositis
contains ovarian vessels

47. Gastrin
G cells
x- linked recessive lysosomal storage diseases
17 alpha hydroxylase deficiency
adenomyosis

48. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
best effect on HDL
MPTP exposure causes depletion of what NT?
SICK PEG
sphingomyelinase deficiency

49. Intussception
strawberry tongue
cells destroyed in Guillain Barre
MofA Levothyroxine
currant jelly stool

50. Facial sensation (Make up on your face)
tumor composed of cytotrophoblasts and syncytiotrophoblasts
thromboxane A2
ventral posterior nucleus - medial part
hydrocele

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USMLE Pathophys

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