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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Superchiasmic nucleus
11 beta hydroxylase deficiency
ventral posterior nucleus - lateral part
master clock for circadian rhythms
best effect of triglycerides/VLDL

2. Fabrys
deficiency of mannose phosphorylation
testicular tumor that can present with gynecomastia
myelinates on PNS
alpha galacosidase A

3. Chediak - Higashi
follicular
child with partial albinism - peripherial neuropathy - recurrent infections
most common protozoal infection in US
increased MCHC and hemolytic anemia

4. Body sensation
ovarian tumor with psammoma bodies
vasculitis of infants and children - involving coronary arteries
propylthiouracil side effects
ventral posterior nucleus - lateral part

5. Somatostatin
Yolk sac tumor produces...
intranuclear inclusions seen in herpes simplex encephalitis
D cells
heXosaminidase

6. Placenta attached to myometrium
drug induced lupus
catalase positive coagulase negative
inheritance pattern for all MENs
plenta accreta

7. Schwann cells
inheritance pattern for all MENs
cells destroyed in Guillain Barre
most common protozoal infection in US
subluxation of lens

8. Papillary
SE: torsades de pointes
pacinian
thyroid cancer associtated with RET oncogene
17 alpha hydroxylase deficiency

9. 2 sperm + 1 egg (fetal parts present)
partial mole components
corneal clouding & MR
anti - epithelial antibodies
Where does the dorsal column decussate?

10. Makes ADH
palisading nuclei - locally invasive
21 hydroxylase deficiency
supraoptic nucleus of hypothalamus
leydig cell tumor

11. Macrolides
vasculitis of infants and children - involving coronary arteries
antibiotic with SE of eosinophilia
bocks PRPP synthetase to block purine synthesis
plenta accreta

12. Fibrates/statins
protease inhibitors MofA
SE: elevated LFTS - myositis
enzyme used to conjugate bilirubin
neutrophils fail to respond to chemotaxic stimuli

13. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
11 beta hydroxylase deficiency
SICK PEG
Bisphosphonates MofA
cause of malignant hyperthermia

14. ACE inhibitors
MPTP exposure causes depletion of what NT?
antibiotic with SE of eosinophilia
Abciximab
shown to slow progression of diabetic neuropathy

15. Penicillamine
anti - mitochondrial antibodies
LTB4
most common first line agent for septic shock
copper - arsenic - gold antidote

16. Secretin
adenomyosis
S cells
what inhibits prolactin secretion
most common testicular tumor

17. Homocystienuria - Marfans
most common primary cardiac tumor in kiddos
failure of endodermal development
subluxation of lens
sclerosing adenosis

18. Antitoxin - penicillin - DPT vaccine
first line for absence seizures
diphtheria treatment
cause of malignant hyperthermia
what meds treat malaria

19. Damaged in multiple sclerosis
oligodendrioglia
brain tumor with fried egg appearance
sphingomyelinase deficiency
antibody against philadelphia chromosome

20. Amygdala
nucleoside reverse transcriptase inhibitors
copper - arsenic - gold antidote
most common breast cancer
kluver bucy

21. CCK
locus ceruleus
I cells
Lewy bodies composition
myelinates multiple CNS axons

22. Polyarteritis nodosa
blood supply for thalamus
increased MCHC and hemolytic anemia
hep B seropositivity in 30% of patients
Shigella

23. Gonorrhea
barbituates withdrawal
GABA - glutamine
microglia
thayer martin media

24. NE
5 alpha reductase deficiency
psammoma bodies
vasculitis of infants and children - involving coronary arteries
most common first line agent for septic shock

25. Radial nerve - deep brachial artery
anti - epithelial antibodies
midshaft break of humerus
UMN signs
gram + bacteria that requires NAD and hemin for growth

26. Hypoglycemia
most common gyno malignancy
brenner tumor
sulfonylureas side effect
grossly black liver

27. Medulla
nucleoside reverse transcriptase inhibitors
Where does the dorsal column decussate?
P450 inducers
solitarius nucleus

28. Gauchers
crinkled paper cytoplasm
What thyroid pathology has an extremely tender thyroid gland
most common testicular tumor
what nerve innervates the muscles of mastication?

29. Seminoma
Where does the spinothalamic decussate?
most common testicular tumor
ependymal cells
3 tumors of MEN 2b

30. Measles
heparin antidote
MPTP exposure causes depletion of what NT?
cough - conjunctivitis - coryza - fever
treatment for SIADH

31. NE
SICK PEG
blood supply for thalamus
locus ceruleus
supraoptic nucleus of hypothalamus

32. HTN - proteinuria - edema
psammoma bodies
preeclampsia
MofA Levothyroxine
What oncogene is a/w MEN 2a/b

33. Oligodendroglia
heparin antidote
looks like fried eggs under histologic staining
What are the hormone changes seen in menopause
brain tumor with fried egg appearance

34. Kawasaki (treat with high dose aspirin)
myelinates multiple CNS axons
3 tumors of MEN 1
ventral posterior nucleus - medial part
strawberry tongue

35. Visceral sensory
most common breast tumor in women under 25
hydatidiform mole with crazy high hCG
solitarius nucleus
UMN signs

36. Microglia
sclerosing adenosis
treatment for SIADH
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
form multinucleated giant cells in the CNS when infected with HIV

37. G1/S & G2/M
ambiguous nucleus
brain tumor with foamy cells and high vascularity
hep B seropositivity in 30% of patients
what checkpoint is p53 involved with?

38. Most common type of thyroid cancer
sclerosing adenosis
papillary thyroid cancer
first line for absence seizures
heparin antidote

39. 5- fluorouracil
form multinucleated giant cells in the CNS when infected with HIV
pt has extended expiratory phase
thymidylate synthase
dose response curve change with competitive antagonist

40. Medullary thyroid - pheochromocytoma - parathryoid
beta glucocerebrosidase
pigmented iris hamartomas - neural tumors
3 tumors of MEN 2a
oligodendrioglia

41. Oligodendrogila
may lead to multiple personalities
cells destroyed in MS
21 hydroxylase deficiency
what meds treat malaria

42. 6- mecaptopurine (metabolized by xanthine oxidase)
bocks PRPP synthetase to block purine synthesis
looks like fried eggs under histologic staining
psammoma bodies
mitral valve prolapse - liver diseae - berry aneurysm

43. Damaged in Guillian Barre
hemosiderinurea and thrombosis
tram - track on microscope
drug induced lupus
schwann cells

44. HTN; masculinization
11 beta hydroxylase deficiency
dermatin sulfate accumulation
optically clear nuclei (orphan annie)
contains ovarian vessels

45. H. Influenza
leydig cell tumor
gram + bacteria that requires NAD and hemin for growth
BCG PQRS
What thyroid pathology has an extremely tender thyroid gland

46. TNF receptor
cancer arising from parafollicular C cells
blocks ADP receptors to inhibit platelet aggregation
etanercept
floppy mitral valve dissecting aortic aneurysm - berry aneurysm

47. Criglar Najar
most common breast mass in postmenopausal women
absent UTPGT
UMN signs
Where does the spinothalamic decussate?

48. Sotalol - quinidine - cisapride
SE: torsades de pointes
What artery causes locked in syndrome
Aschoff bodies
cause of low pH vaginal discharge

49. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
gram + bacteria that requires NAD and hemin for growth
3 tumors of MEN 1
opioid withdrawal
form multinucleated giant cells in the CNS when infected with HIV

50. Decreased FEV/FVC ratio
meissners
copper - arsenic - gold antidote
vasculitis of infants and children - involving coronary arteries
hallmark sign of COPD