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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Port wine stains - ipsilateral leptomeningeal angioma; can cause glaucoma - seizures - hemipareis - and MR
cancer arising from parafollicular C cells
grossly black liver
lewy body composition
sturge weber syndrome

2. ADPKD
sclerosing adenosis
mitral valve prolapse - liver diseae - berry aneurysm
what cells secrete somatostatin
What causes coronary vasospasm as a SE?

3. Legionella
psammoma bodies
cancer associated with Hashimoto's thyroiditis
silver stain of gram negative rods
LTB4

4. Facial sensation (Make up on your face)
ventral posterior nucleus - medial part
most common bacteria in GI tract
etanercept
order of nerve blockade

5. Trigeminal
LTB4
cause of increased myometrial excitability
what nerve innervates the muscles of mastication?
increased MCHC and hemolytic anemia

6. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
drug induced lupus
3 tumors of MEN 2b
probenecid
5 alpha reductase deficiency

7. Gauchers
lead antidote
beta glucocerebrosidase
propylthiouracil side effects
first line for absence seizures

8. Hurlers
alpha L iduronidase
hemangioblastomas of retina/cerebellum/medulla
what inhibits prolactin secretion
heXosaminidase

9. Makes ADH
Where does the dorsal column decussate?
sphingomyelinase deficiency
alpha L iduronidase
supraoptic nucleus of hypothalamus

10. Inner lining of ventricles - make CSF - originate from neuroectoderm
sarcoma botyroides
ependymal cells
lisch nodules
form multinucleated giant cells in the CNS when infected with HIV

11. Medulla
Where does the dorsal column decussate?
basal nucleus of Meynert
looks like fried eggs under histologic staining
hemangioblastomas of retina/cerebellum/medulla

12. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
propylthiouracil side effects
SE: elevated LFTS - myositis
ovarian tumor with psammoma bodies
BCG PQRS

13. Benign - contains Reinke crystals - usually androgen producing
ovarian tumor with elevate hCG
leydig cell tumor
blood supply for thalamus
alpha L iduronidase

14. 2 sperm + empty egg (no fetal parts)
found in hairless skin
most common first line agent for septic shock
Shigella
complete mole components

15. Neurofibromatosis
most common breast mass in postmenopausal women
epithelial
lisch nodules
increased MCHC and hemolytic anemia

16. Incomplete fusion of processus vaginalis
hydrocele
GFAP positive
LTB4
melanoma tumor marker

17. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
cells destroyed in Guillain Barre
protease inhibitors MofA
myelinates multiple CNS axons
opioid withdrawal

18. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
cancer arising from parafollicular C cells
first line for cardiogenic shock
plenta accreta
LTB4

19. TNF receptor
treatment for SIADH
sumatriptan
thymidylate synthase
etanercept

20. Hypoglycemia
G cells
UMN signs
sulfonylureas side effect
most common breast cancer

21. Fibrates/statins
SE: elevated LFTS - myositis
myelinates on PNS
erythema nodosum
most common arrthymia

22. Bilateral renal agenesis or posterior urethral valves in males
brenner tumor
cause of malignant hyperthermia
oligohydramnios
PTU

23. G1/S & G2/M
ambiguous nucleus
leydig cell tumor
tumor with call - exner bodies
what checkpoint is p53 involved with?

24. Chocolate agar
3 tumors of MEN 2b
MofA Levothyroxine
melanoma tumor marker
H. flu

25. Ret
propylthiouracil side effects
What oncogene is a/w MEN 2a/b
heXosaminidase
spike and dome on microscope

26. Streptococcus
iduronidase sulfatase
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
catalase negative
kluver bucy

27. Yolk sac
ovarian tumor that resembles bladder epithelium
lysosomal storage disease a/w renal disease
intranuclear inclusions seen in herpes simplex encephalitis
most common testicular tumor in infants and children up to 3 years of age

28. Masculinization - hypovolemic shock
myelinates multiple CNS axons
21 hydroxylase deficiency
basal nucleus of Meynert
sulfonylureas side effect

29. Rheumatic fever
anti - mitochondrial antibodies
low dose ASA effects - intermediate dose - high dose
Aschoff bodies
lisch nodules

30. Gauchers
SE: torsades de pointes
brain tumor with fried egg appearance
most common lysosomal storage disease
TZD (glitazones) MofA

31. Hemolysis - elevated LFTs - Low Platelets
tram - track on microscope
brain tumor with perivascular pseudorosettes
HELLP syndrome
BCG PQRS

32. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
most common testicular tumor in infants and children up to 3 years of age
catalase positive coagulase negative
sulfonylureas MofA
follicular

33. Oligodendoglia
UMN signs
myelinates multiple CNS axons
homer wright rosettes
sulfonylureas MofA

34. Hurlers - Hunters
fusion inhibitors
cells destroyed in Guillain Barre
Schiller Duval bodies
dermatin sulfate accumulation

35. Bromocriptine
cancer arising from parafollicular C cells
ovarian tumor with psammoma bodies
oligohydramnios
what inhibits prolactin secretion

36. Negri bodies
hemosiderinurea + thrombosis
ambiguous nucleus
17 alpha hydroxylase deficiency
rabies

37. Medulla
hippocampus
ventral posterior nucleus - medial part
solitarius nucleus
Where does the lateral corticospinal decussate?

38. Combo of inhaled anesthetics & succinylcholine
Addison's
cause of malignant hyperthermia
ambiguous nucleus
child with eczema - coarse facial features - cold abscesses

39. Aplastic anemia - rash - agranulocytosis
mitral valve prolapse - liver diseae - berry aneurysm
pseudopalisading necrosis
propylthiouracil side effects
partial mole components

40. Primary hyperaldosteronism (HTN - hypokalemia - metabolic alkalosis)

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41. Pacinian
supraoptic nucleus of hypothalamus
x- linked recessive lysosomal storage diseases
medial geniculate nucleus
resembles an onion in cross section

42. Measles
cough - conjunctivitis - coryza - fever
drug induced lupus
t - PA - streptokinase antidote
LTB4

43. Estrogen
alpha galacosidase A
cause of LH surge
Where does the lateral corticospinal decussate?
ovarian tumor with elevate hCG

44. Hemangioblastoma
benzos antidote
Conn's syndrome
brain tumor a/w von hipple - linadu syndrome
alpha L iduronidase

45. Parathyroid - pituitary - pancreatic
chromosome 4
eczema/recurrent infections/thrombocytopenia
most common gyno malignancy
3 tumors of MEN 1

46. Hairless skin - dynamic fine touch
lysosomal storage disease - demyelinating disease
meissners
Abciximab
partial mole components

47. Vibration - pressure
failure of endodermal development
placenta previa
medial geniculate nucleus
pacinian

48. Subacute (De Quervain's) thyroiditis
What thyroid pathology has an extremely tender thyroid gland
lisch nodules
raphe nucleus
Galactocerebrosidase deficiency

49. Achondroplasia
FGFR3 mutation
treatment of malignant hyperthermia
macrolides use (PUS)
cancer associated with Hashimoto's thyroiditis

50. Estrogen (causes precocious puberty)
most common breast tumor in women under 25
chief cells
eczema/recurrent infections/thrombocytopenia
granulosa cell tumor secretes what?