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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Fabry's & Hunters
brain tumor with psammona bodies
thromboxane A2
x- linked recessive lysosomal storage diseases
sulfonylureas

2. Inner lining of ventricles - make CSF - originate from neuroectoderm
deficiency of mannose phosphorylation
shown to slow progression of diabetic neuropathy
looks like fried eggs under histologic staining
ependymal cells

3. Polyarteritis nodosa
sulfonylureas side effect
sumatriptan
preeclampsia
hep B seropositivity in 30% of patients

4. Lactic acidosis
drug induced lupus
polyhydramnios
metformin side effect
opioids antidote

5. Decreased efficacy - decreased Vmax
hydrocele
dose response curve with noncompetitive antagonist
branching rods on oral infection
placenta previa

6. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
anti - platelet antibodies
kawasaki
ambiguous nucleus
Where does the spinothalamic decussate?

7. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
treatment of malignant hyperthermia
sulfonylureas MofA
leydig cell tumor
LT C4 D4 E4

8. Gilberts
BCG PQRS
thayer martin media
mildly decreased UDPGT
homer wright rosettes

9. Hunters
child with eczema - coarse facial features - cold abscesses
first line for cardiogenic shock
iduronidase sulfatase
brenner tumor

10. Second most common type of thyroid cancer
follicular
chief cells
which nerve lifts the eyelid?
MofA of N- aceylcysteine

11. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
best effect on HDL
colchicine
chromosome 4
dose response curve with noncompetitive antagonist

12. H. Influenza
G cells
order of nerve blockade
dorsal motor nucleus
gram + bacteria that requires NAD and hemin for growth

13. Decreased follicles & estrogen with increased FSH & LH
whats the V/Q at the base of the lung
What are the hormone changes seen in menopause
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
contains ovarian vessels

14. A few levels above the level of entry
most common testicular tumor in infants and children up to 3 years of age
blood supply for thalamus
Where does the spinothalamic decussate?
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

15. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
SICK PEG
3 tumors of MEN 1
Galactocerebrosidase deficiency
tumor with call - exner bodies

16. Estrogen
etanercept
cause of LH surge
child with eczema - coarse facial features - cold abscesses
What hormones share a common alpha subunit

17. I- cell disease
deficiency of mannose phosphorylation
benzos antidote
3 tumors of MEN 1
Bisphosphonates MofA

18. TNF receptor
SE: torsades de pointes
etanercept
MofA of N- aceylcysteine
ovarian tumor with elevate hCG

19. Aplastic anemia - rash - agranulocytosis
hippocampus
propylthiouracil side effects
sumatriptan
cause of LH surge

20. Body sensation
first line for cardiogenic shock
ventral posterior nucleus - lateral part
thromboxane A2
Schiller Duval bodies

21. Dubin Johnson
cancer associated with Hashimoto's thyroiditis
alpha galacosidase A
grossly black liver
cause of LH surge

22. Niemann Pick
sturge weber syndrome
sphingomyelinase deficiency
cancer associated with Hashimoto's thyroiditis
schwann cells

23. Schwann cells
myelinates multiple CNS axons
3 tumors of MEN 2a
chief cells
myelinates on PNS

24. Impetigo
3 tumors of MEN 1
S cells
meissners
honey crusted lesions common around nose/lips

25. Papillary
heXosaminidase
hemangioblastomas of retina/cerebellum/medulla
thyroid cancer associtated with RET oncogene
VA/VL

26. Subacute (De Quervain's) thyroiditis
metformin side effect
leydig cell tumor
partial mole components
What thyroid pathology has an extremely tender thyroid gland

27. NF 1
kluver bucy
intranuclear inclusions seen in herpes simplex encephalitis
chief cells
pigmented iris hamartomas - neural tumors

28. Placenta attached to myometrium
t - PA - streptokinase antidote
colchicine
plenta accreta
kluver bucy

29. Causes vasoconstriction (use for acute migraines)
sumatriptan
SE: elevated LFTS - myositis
alpha galacosidase A
sclerosing adenosis

30. Medulla
hydrocele
Where does the lateral corticospinal decussate?
enzyme used to conjugate bilirubin
alpha 1 anti - trypsin

31. Medulloblastoma
brenner tumor
homer wright rosettes
most common primary cardiac tumor in kiddos
pacinian

32. Job's or LAD
neutrophils fail to respond to chemotaxic stimuli
Where does the dorsal column decussate?
sulfonylureas side effect
catalase positive coagulase negative

33. Fibrates/statins
lisch nodules
vasculitis of infants and children - involving coronary arteries
fusion inhibitors
SE: elevated LFTS - myositis

34. Premature detachment of placenta - painful bleeding in 3rd trimester
abruptio placentae
raphe nucleus
ventral posterior nucleus - lateral part
SE: elevated LFTS - myositis

35. Makes oxytocin
paraventricular nucleus of hypothalamus
vasculitis of infants and children - involving coronary arteries
anti - platelet antibodies
most common lysosomal storage disease

36. DiGeorge
cause of LH surge
Addison's
master clock for circadian rhythms
failure of endodermal development

37. Medullary
cancer arising from parafollicular C cells
basal nucleus of Meynert
cause of LH surge
most common testicular tumor in infants and children up to 3 years of age

38. Inhibitory in the brain - stimulatory in the brain
sturge weber syndrome
MofA Levothyroxine
GABA - glutamine
grossly black liver

39. Ach
basal nucleus of Meynert
crinkled paper cytoplasm
sulfonylureas
brain tumor a/w von hipple - linadu syndrome

40. Gastrin
P450 inducers
G cells
antibody against philadelphia chromosome
eczema/recurrent infections/thrombocytopenia

41. Primary biliary cirrhosis
mildly decreased UDPGT
pt has extended expiratory phase
thromboxane A2
anti - mitochondrial antibodies

42. Increased acini and intralobular fibrosis
Yolk sac tumor produces...
SE: elevated LFTS - myositis
neutrophils fail to respond to chemotaxic stimuli
sclerosing adenosis

43. Atrial fibrillation
5 alpha reductase deficiency
most common arrthymia
lysosomal storage disease a/w renal disease
drug that blocks purine synthesis and is metabolized by xanthine oxidase

44. Estrogen
lisch nodules
silver stain of gram negative rods
cause of increased myometrial excitability
fusion inhibitors

45. Actinomyces
basal nucleus of Meynert
Lewy bodies composition
iduronidase sulfatase
branching rods on oral infection

46. Combo of inhaled anesthetics & succinylcholine
H. flu
protease inhibitors MofA
cause of malignant hyperthermia
keratin filled cysts

47. A/w esophageal/duodenal atresia and anencephaly
benzos antidote
most common arrthymia
polyhydramnios
most common testicular tumor in infants and children up to 3 years of age

48. Pemphigus vulgaris
dorsal motor nucleus
anti - epithelial antibodies
thayer martin media
macrolides use (PUS)

49. 2 sperm + empty egg (no fetal parts)
PGI2 (prostacyclin))
complete mole components
corneal clouding & MR
alpha L iduronidase

50. Inhibitory in the SC
low dose ASA effects - intermediate dose - high dose
I cells
glycine
propylthiouracil side effects