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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Gauchers
cause of high pH vaginal discharge
most common lysosomal storage disease
pacinian
pseudopalisading necrosis

2. Suspensory ligament of ovaries
most common lysosomal storage disease
sphingomyelinase deficiency
epithelial
contains ovarian vessels

3. Ret
alpha galacosidase A
ependymal cells
What oncogene is a/w MEN 2a/b
most common breast tumor in women under 25

4. Fabry's & Hunters
x- linked recessive lysosomal storage diseases
alpha galacosidase A
looks like fried eggs under histologic staining
vasculitis of infants and children - involving coronary arteries

5. Cant convert testosterone to DHT - ambiguous genitalia until puberty then penis at 12
lysosomal storage disease a/w renal disease
5 alpha reductase deficiency
optically clear nuclei (orphan annie)
lysosomal storage disease - demyelinating disease

6. Weakness - atrophy - fasiculations - decreased reflexes & tone
antibody against philadelphia chromosome
LMN signs
TZD (glitazones) MofA
opioid withdrawal

7. Niacins
opioid withdrawal
best effect on HDL
myelinates on PNS
MPTP exposure causes depletion of what NT?

8. TSH - LH - FSH - hCG
What hormones share a common alpha subunit
sulfonylureas
I cells
hep B seropositivity in 30% of patients

9. Cocain and sumatriptan
Yolk sac tumor produces...
mildly decreased UDPGT
thayer martin media
What causes coronary vasospasm as a SE?

10. Pneumonia - URIs - STDS
PTU
macrolides use (PUS)
chromosome 4
placenta previa

11. Yolk sac
nucleoside reverse transcriptase inhibitors
most common testicular tumor in infants and children up to 3 years of age
pigmented iris hamartomas - neural tumors
S cells

12. D cells of pancreas and gut
what cells secrete somatostatin
raphe nucleus
defective tyrosine kinase
17 alpha hydroxylase deficiency

13. Wiscott - Aldrich
astrocytes
microglia
MofA Levothyroxine
eczema/recurrent infections/thrombocytopenia

14. Facial sensation (Make up on your face)
ventral posterior nucleus - medial part
chief cells
beta glucocerebrosidase
kawasaki

15. Antibody binds to gp2b/3a - preventing aggregation
Abciximab
smoking emphysema
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
FGFR3 mutation

16. Membranoproliferative GN
I cells
brenner tumor
tram - track on microscope
HELLP syndrome

17. Bruton's agammaglobulinemia
oligodendrioglia
defective tyrosine kinase
drug induced lupus
hemangioblastomas of retina/cerebellum/medulla

18. Estrogen
Abciximab
cause of LH surge
von Hippel Lindau disease
Addison's

19. Endometrial CA
catalase positive coagulase negative
paraventricular nucleus of hypothalamus
most common gyno malignancy
may lead to multiple personalities

20. Krabbe's
midshaft break of humerus
pigmented iris hamartomas - neural tumors
Galactocerebrosidase deficiency
SE: elevated LFTS - myositis

21. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
MofA Levothyroxine
SE: facial flushing
opioid withdrawal
melanoma tumor marker

22. Hemangioblastoma
brain tumor with foamy cells and high vascularity
silver stain of gram negative rods
H. flu
chromosome 4

23. Penicillamine
best effect on HDL
astrocytes
copper - arsenic - gold antidote
microglia

24. Dimercaprol
kluver bucy
H. flu
lead antidote
plenta accreta

25. Streptococcus
H. flu
catalase negative
leydig cell tumor
papillary thyroid cancer

26. HTN; XY will be a girl - XX will lack secondary sex char.
LT C4 D4 E4
MofA of N- aceylcysteine
Galactocerebrosidase deficiency
17 alpha hydroxylase deficiency

27. S-100
melanoma tumor marker
propylthiouracil side effects
tumor with call - exner bodies
dose response curve with noncompetitive antagonist

28. Lymphoma

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29. Vibration - pressure
pacinian
hemosiderinurea + thrombosis
Where does the dorsal column decussate?
SICK PEG

30. Decreased potency - increased Km
microglia
drug that blocks purine synthesis and is metabolized by xanthine oxidase
dose response curve change with competitive antagonist
GFAP positive

31. Lactic acidosis
metformin side effect
UMN signs
myelinates on PNS
failure of endodermal development

32. Intussception
cause of low pH vaginal discharge
sulfonylureas
currant jelly stool
meissners

33. Oligosaccaride hydrolase
thromboxane A2
plenta accreta
rabies
rate limiting step in carb digestion

34. Measles
cough - conjunctivitis - coryza - fever
tram - track on microscope
opioid withdrawal
crinkled paper cytoplasm

35. Premature detachment of placenta - painful bleeding in 3rd trimester
x- linked recessive lysosomal storage diseases
sulfonylureas MofA
abruptio placentae
barbituates withdrawal

36. Choriocarcinoma or dysgerminoma
hemosiderinurea and thrombosis
metformin side effect
lysosomal storage disease a/w renal disease
ovarian tumor with elevate hCG

37. SCID
child with eczema - coarse facial features - cold abscesses
macrolides use (PUS)
basal nucleus of Meynert
sulfonylureas side effect

38. Most common type of thyroid cancer
papillary thyroid cancer
brain tumor with fried egg appearance
most common breast cancer
most common primary cardiac tumor in kiddos

39. HTN; masculinization
benzos antidote
3 tumors of MEN 2a
11 beta hydroxylase deficiency
branching rods on oral infection

40. Polyarteritis nodosa
hep B seropositivity in 30% of patients
defective tyrosine kinase
chromosome 4
alpha galacosidase A

41. Superchiasmic nucleus
master clock for circadian rhythms
most common breast cancer
strawberry tongue
FGFR3 mutation

42. Medulla
form multinucleated giant cells in the CNS when infected with HIV
What artery causes locked in syndrome
anti - mitochondrial antibodies
Where does the dorsal column decussate?

43. Norepinephrine
sturge weber syndrome
locus ceruleus
failure of endodermal development
most common arrthymia

44. Naloxone/naltrexone
best effect of triglycerides/VLDL
form multinucleated giant cells in the CNS when infected with HIV
opioids antidote
thymidylate synthase

45. Normal or candida
cause of increased myometrial excitability
placenta previa
absent UTPGT
cause of low pH vaginal discharge

46. Legionella
which nerve lifts the eyelid?
LTB4
silver stain of gram negative rods
gram + bacteria that requires NAD and hemin for growth

47. Decreased FEV/FVC ratio
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
most common gyno malignancy
hallmark sign of COPD
brain tumor with fried egg appearance

48. Gonorrhea
heXosaminidase
psammoma bodies
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
thayer martin media

49. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
erythema nodosum
S cells
VA/VL
SE: elevated LFTS - myositis

50. Astrocytoma & glioblastoma multiforme
3 tumors of MEN 1
bocks PRPP synthetase to block purine synthesis
blood supply for thalamus
GFAP positive