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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Aminocaproic acid
5 alpha reductase deficiency
order of nerve blockade
adenomyosis
t - PA - streptokinase antidote

2. Seminoma
sphingomyelinase deficiency
most common testicular tumor
most common breast mass in pre - menopausal women
brain tumor with fried egg appearance

3. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
lysosomal storage disease a/w renal disease
pseudopalisading necrosis
BCG PQRS
SE: torsades de pointes

4. Pacinian
sturge weber syndrome
resembles an onion in cross section
cough - conjunctivitis - coryza - fever
sclerosing adenosis

5. Prevents incorporation into host DNA
brain tumor with perivascular pseudorosettes
ventral posterior nucleus - lateral part
nucleoside reverse transcriptase inhibitors
locus ceruleus

6. Normal or candida
cause of low pH vaginal discharge
FGFR3 mutation
failure of endodermal development
sturge weber syndrome

7. Basal cell carcinoma
t - PA - streptokinase antidote
may lead to multiple personalities
palisading nuclei - locally invasive
inheritance pattern for all MENs

8. Increased acini and intralobular fibrosis
astrocytes
bocks PRPP synthetase to block purine synthesis
sclerosing adenosis
lead antidote

9. Rhabdomyoma
eczema/recurrent infections/thrombocytopenia
granulosa cell tumor secretes what?
most common primary cardiac tumor in kiddos
microglia

10. Inner lining of ventricles - make CSF - originate from neuroectoderm
ependymal cells
order of nerve blockade
crinkled paper cytoplasm
smoking emphysema

11. Posterior communicating - posterior cerebral - anterior choroidal arteries
ventral posterior nucleus - lateral part
what checkpoint is p53 involved with?
von Hippel Lindau disease
blood supply for thalamus

12. Prazosin
astrocytes
melanoma tumor marker
chromosome 4
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

13. Tay Sachs
GM2 ganglioside accumulation
ependymal cells
most common arrthymia
catalase positive coagulase negative

14. Gastrin
G cells
most common testicular tumor in infants and children up to 3 years of age
keratin filled cysts
probenecid

15. Oligodendrioma
brain tumor with fried egg appearance
cause of low pH vaginal discharge
whats the V/Q at the apex of the lung
opioids antidote

16. Fabry's & Hunters
anti - epithelial antibodies
inheritance pattern for all MENs
x- linked recessive lysosomal storage diseases
locus ceruleus

17. Glutamate
brain tumor with foamy cells and high vascularity
Addison's
probenecid
precursor to GABA

18. Fibrates
partial mole components
barbituates withdrawal
best effect of triglycerides/VLDL
enzyme used to conjugate bilirubin

19. Inhibits osteoclastic activity
Bisphosphonates MofA
lead antidote
protease inhibitors MofA
hippocampus

20. Visual (Lateral for Light)
intranuclear inclusions seen in herpes simplex encephalitis
Lateral geniculate nucleus
tumor with call - exner bodies
anti - platelet antibodies

21. Huntingtons chorea
chromosome 4
sturge weber syndrome
hydatidiform mole with crazy high hCG
hemangioblastomas of retina/cerebellum/medulla

22. Gauchers
LMN signs
crinkled paper cytoplasm
What are the hormone changes seen in menopause
plenta accreta

23. Actinomyces
basal nucleus of Meynert
11 beta hydroxylase deficiency
PTU
branching rods on oral infection

24. Niacins
iduronidase sulfatase
resembles an onion in cross section
best effect on HDL
LMN signs

25. Superchiasmic nucleus
chief cells
alpha galacosidase A
master clock for circadian rhythms
enzyme used to conjugate bilirubin

26. Achondroplasia
FGFR3 mutation
strawberry tongue
anti - epithelial antibodies
lewy body composition

27. Polyarteritis nodosa
placenta previa
vasculitis a/w Hep B
first line for absence seizures
Galactocerebrosidase deficiency

28. Auditory (Medial for Music)
medial geniculate nucleus
cancer associated with Hashimoto's thyroiditis
FGFR3 mutation
PTU

29. Vibration - pressure
kluver bucy
pacinian
tram - track on microscope
lysosomal storage disease a/w renal disease

30. Homocystienuria - Marfans
subluxation of lens
grossly black liver
blood supply for thalamus
enzyme used to conjugate bilirubin

31. Small diameter > large diameter; myelinated > unmyelinated
whats the V/Q at the apex of the lung
order of nerve blockade
t - PA - streptokinase antidote
precursor to GABA

32. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
colchicine
Bisphosphonates MofA
what nerve innervates the muscles of mastication?
sulfonylureas side effect

33. Damaged in multiple sclerosis
hippocampus
oligodendrioglia
most common breast cancer
Schiller Duval bodies

34. Babinski - weakness - increased reflexes & tone - spastic paralysis
opioids antidote
UMN signs
hydrocele
rate limiting step in carb digestion

35. G1/S & G2/M
intranuclear inclusions seen in herpes simplex encephalitis
sumatriptan
what checkpoint is p53 involved with?
21 hydroxylase deficiency

36. Serous cystadenocarcinoma
ovarian tumor with psammoma bodies
What artery causes locked in syndrome
brain tumor with perivascular pseudorosettes
Conn's syndrome

37. Estrogen
increased MCHC and hemolytic anemia
sclerosing adenosis
cause of increased myometrial excitability
von Hippel Lindau disease

38. 5- fluorouracil
most common lysosomal storage disease
absent UTPGT
thymidylate synthase
thromboxane A2

39. Hemangioblastoma
brain tumor a/w von hipple - linadu syndrome
thymidylate synthase
ovarian tumor that resembles bladder epithelium
erythema nodosum

40. Macrophages of the CNS
barbituates withdrawal
Conn's syndrome
best effect of triglycerides/VLDL
microglia

41. Schwann cells
what inhibits prolactin secretion
GABA - glutamine
cells destroyed in Guillain Barre
absent UTPGT

42. Dantrolene (prevents release of calcium from SR of muscle)
treatment of malignant hyperthermia
oligohydramnios
thromboxane A2
hallmark sign of COPD

43. 6- MP
drug that blocks purine synthesis and is metabolized by xanthine oxidase
medial geniculate nucleus
What are the hormone changes seen in menopause
hydrocele

44. Granulosa cell tumor
tumor with call - exner bodies
I cells
oligohydramnios
smoking emphysema

45. Leydig cell tumor
FGFR3 mutation
Yolk sac tumor produces...
testicular tumor that can present with gynecomastia
hippocampus

46. Oculomotor
Shigella
whats the V/Q at the base of the lung
which nerve lifts the eyelid?
contains ovarian vessels

47. Dissociative
What causes coronary vasospasm as a SE?
cough - conjunctivitis - coryza - fever
may lead to multiple personalities
heXosaminidase

48. Centriacinar
lead antidote
currant jelly stool
failure of endodermal development
smoking emphysema

49. Endometrial glands inside myometrium
supraoptic nucleus of hypothalamus
17 alpha hydroxylase deficiency
most common arrthymia
adenomyosis

50. Naloxone/naltrexone
vasculitis of infants and children - involving coronary arteries
opioids antidote
brain tumor with perivascular pseudorosettes
21 hydroxylase deficiency