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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. D cells of pancreas and gut
best effect of triglycerides/VLDL
what cells secrete somatostatin
glycine
pigmented iris hamartomas - neural tumors

2. Rhabdomyoma
most common primary cardiac tumor in kiddos
UMN signs
most common breast mass in postmenopausal women
SICK PEG

3. Dopamine
may lead to multiple personalities
MPTP exposure causes depletion of what NT?
optically clear nuclei (orphan annie)
eczema/recurrent infections/thrombocytopenia

4. Neurofibromatosis
dermatin sulfate accumulation
Galactocerebrosidase deficiency
dose response curve change with competitive antagonist
lisch nodules

5. Intussception
sphingomyelinase deficiency
currant jelly stool
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
S cells

6. Babinski - weakness - increased reflexes & tone - spastic paralysis
testicular tumor that can present with gynecomastia
blood supply for thalamus
UMN signs
antibiotic with SE of eosinophilia

7. Tay Sachs
cough - conjunctivitis - coryza - fever
GM2 ganglioside accumulation
brain tumor a/w von hipple - linadu syndrome
meissners

8. Facial sensation (Make up on your face)
basal nucleus of Meynert
order of nerve blockade
ventral posterior nucleus - medial part
keratin filled cysts

9. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
TZD (glitazones) MofA
propylthiouracil side effects
dorsal motor nucleus
myelinates multiple CNS axons

10. Polyarteritis nodosa
3 tumors of MEN 2b
vasculitis a/w Hep B
What oncogene is a/w MEN 2a/b
currant jelly stool

11. Decreased efficacy - decreased Vmax
VA/VL
barbituates withdrawal
dose response curve with noncompetitive antagonist
Schiller Duval bodies

12. Bruton's agammaglobulinemia
sturge weber syndrome
locus ceruleus
most common breast mass in pre - menopausal women
defective tyrosine kinase

13. Medulloblastoma
thyroid cancer associtated with RET oncogene
homer wright rosettes
lead antidote
VA/VL

14. Atrial fibrillation
most common arrthymia
what cells secrete somatostatin
hallmark sign of COPD
bocks PRPP synthetase to block purine synthesis

15. Pacinian
resembles an onion in cross section
Where does the dorsal column decussate?
metformin side effect
keratin filled cysts

16. Clopidogrel - ticoplidine
follicular
blocks ADP receptors to inhibit platelet aggregation
MofA Levothyroxine
leydig cell tumor

17. Dobutamine
Lateral geniculate nucleus
most common arrthymia
most common lysosomal storage disease
first line for cardiogenic shock

18. Papillary CA of thyroid
optically clear nuclei (orphan annie)
partial mole components
erythema nodosum
branching rods on oral infection

19. H. Influenza
deficiency of mannose phosphorylation
whats the V/Q at the apex of the lung
gram + bacteria that requires NAD and hemin for growth
corneal clouding & MR

20. Decreased FEV/FVC ratio
midshaft break of humerus
FGFR3 mutation
hallmark sign of COPD
thayer martin media

21. Suspensory ligament of ovaries
most common breast cancer
hemangioblastomas of retina/cerebellum/medulla
copper - arsenic - gold antidote
contains ovarian vessels

22. Small diameter > large diameter; myelinated > unmyelinated
paraventricular nucleus of hypothalamus
barbituates withdrawal
order of nerve blockade
5 alpha reductase deficiency

23. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
brain tumor with perivascular pseudorosettes
melanoma tumor marker
antibody against philadelphia chromosome
low dose ASA effects - intermediate dose - high dose

24. Meissner
found in hairless skin
locus ceruleus
Where does the spinothalamic decussate?
anti - mitochondrial antibodies

25. Antibody binds to gp2b/3a - preventing aggregation
iduronidase sulfatase
drug induced lupus
most common breast mass in postmenopausal women
Abciximab

26. Fibrocystic
what cells secrete somatostatin
Shigella
most common lysosomal storage disease
most common breast mass in pre - menopausal women

27. Cant convert testosterone to DHT - ambiguous genitalia until puberty then penis at 12
5 alpha reductase deficiency
brain tumor with psammona bodies
absent UTPGT
palisading nuclei - locally invasive

28. Inner lining of ventricles - make CSF - originate from neuroectoderm
supraoptic nucleus of hypothalamus
ependymal cells
ovarian tumor with psammoma bodies
hemangioblastomas of retina/cerebellum/medulla

29. Sotalol - quinidine - cisapride
SE: torsades de pointes
hep B seropositivity in 30% of patients
child with eczema - coarse facial features - cold abscesses
may lead to multiple personalities

30. Yolk sac
diphtheria treatment
subluxation of lens
most common testicular tumor in infants and children up to 3 years of age
most common testicular tumor

31. Basal cell carcinoma
SE: torsades de pointes
crinkled paper cytoplasm
palisading nuclei - locally invasive
MPTP exposure causes depletion of what NT?

32. Hemangioblastoma
spike and dome on microscope
brain tumor with foamy cells and high vascularity
most common gyno malignancy
ependymal cells

33. Papillary
first line for absence seizures
ventral posterior nucleus - lateral part
benzos antidote
thyroid cancer associtated with RET oncogene

34. Autosomal dominant
most common bacteria in GI tract
lead antidote
best effect on HDL
inheritance pattern for all MENs

35. Brenners tumor
granulosa cell tumor secretes what?
benzos antidote
follicular
ovarian tumor that resembles bladder epithelium

36. TSH - LH - FSH - hCG
ambiguous nucleus
antibody against philadelphia chromosome
What are the hormone changes seen in menopause
What hormones share a common alpha subunit

37. Leydig cell tumor
looks like fried eggs under histologic staining
preeclampsia
What artery causes locked in syndrome
testicular tumor that can present with gynecomastia

38. Trigeminal
what nerve innervates the muscles of mastication?
basal nucleus of Meynert
cells destroyed in MS
sulfonylureas side effect

39. Aminocaproic acid
what nerve innervates the muscles of mastication?
cause of LH surge
t - PA - streptokinase antidote
form multinucleated giant cells in the CNS when infected with HIV

40. Increased acini and intralobular fibrosis
sclerosing adenosis
benzos antidote
rate limiting step in carb digestion
most common breast cancer

41. Normal or candida
cause of low pH vaginal discharge
increased MCHC and hemolytic anemia
smoking emphysema
granulosa cell tumor secretes what?

42. Membranous GN
spike and dome on microscope
basal nucleus of Meynert
most common testicular tumor
blood supply for thalamus

43. Damaged in multiple sclerosis
Conn's syndrome
sulfonylureas
oligodendrioglia
sclerosing adenosis

44. Gilberts
low dose ASA effects - intermediate dose - high dose
silver stain of gram negative rods
mildly decreased UDPGT
paraventricular nucleus of hypothalamus

45. Ovarian bengin tumor...looks like bladder
What causes coronary vasospasm as a SE?
ovarian tumor with elevate hCG
What artery causes locked in syndrome
brenner tumor

46. ADPKD
adenomyosis
mitral valve prolapse - liver diseae - berry aneurysm
What hormones share a common alpha subunit
metformin side effect

47. Intrinsic factor
What oncogene is a/w MEN 2a/b
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
parietal cells
propylthiouracil side effects

48. Alpha feto protein
benzos antidote
brain tumor a/w von hipple - linadu syndrome
alpha 1 anti - trypsin
Yolk sac tumor produces...

49. Serous cystadenocarcinoma
opioids antidote
brain tumor with foamy cells and high vascularity
ovarian tumor with psammoma bodies
thromboxane A2

50. Legionella
what checkpoint is p53 involved with?
which nerve lifts the eyelid?
silver stain of gram negative rods
Aschoff bodies