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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Weakness - atrophy - fasiculations - decreased reflexes & tone
Lewy bodies composition
anti - mitochondrial antibodies
LMN signs
drug that blocks purine synthesis and is metabolized by xanthine oxidase

2. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
LTB4
brain tumor with perivascular pseudorosettes
lead antidote
shown to slow progression of diabetic neuropathy

3. Marfans
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
adenomyosis
11 beta hydroxylase deficiency
grossly black liver

4. Premature detachment of placenta - painful bleeding in 3rd trimester
alpha 1 anti - trypsin
abruptio placentae
may lead to multiple personalities
anti - platelet antibodies

5. Job's or LAD
3 tumors of MEN 2b
neutrophils fail to respond to chemotaxic stimuli
anti - epithelial antibodies
found in hairless skin

6. ITP
most common lysosomal storage disease
lysosomal storage disease a/w renal disease
most common testicular tumor in infants and children up to 3 years of age
anti - platelet antibodies

7. Intrinsic factor
crinkled paper cytoplasm
palisading nuclei - locally invasive
blood supply for thalamus
parietal cells

8. Superchiasmic nucleus
neutrophils fail to respond to chemotaxic stimuli
master clock for circadian rhythms
infliximab
best effect on HDL

9. Auditory (Medial for Music)
medial geniculate nucleus
astrocytes
LMN signs
microglia

10. Visceral sensory
solitarius nucleus
drug that blocks purine synthesis and is metabolized by xanthine oxidase
cancer arising from parafollicular C cells
grossly black liver

11. NE
drug induced lupus
most common breast cancer
most common first line agent for septic shock
enzyme used to conjugate bilirubin

12. Chediak - Higashi
most common protozoal infection in US
ambiguous nucleus
most common arrthymia
child with partial albinism - peripherial neuropathy - recurrent infections

13. Macconkey's agar
3 tumors of MEN 2b
Shigella
optically clear nuclei (orphan annie)
most common arrthymia

14. TSH - LH - FSH - hCG
which nerve lifts the eyelid?
SE: torsades de pointes
Yolk sac tumor produces...
What hormones share a common alpha subunit

15. Choriocarcinoma or dysgerminoma
cells destroyed in MS
ovarian tumor with elevate hCG
von Hippel Lindau disease
enzyme used to conjugate bilirubin

16. Measles
protease inhibitors MofA
which nerve lifts the eyelid?
cough - conjunctivitis - coryza - fever
first line for cardiogenic shock

17. Hypoglycemia
sulfonylureas side effect
lisch nodules
schwann cells
3 tumors of MEN 2a

18. Fabrys
VA/VL
LTB4
alpha galacosidase A
SICK PEG

19. Oligosaccaride hydrolase
anti - platelet antibodies
rate limiting step in carb digestion
abruptio placentae
resembles an onion in cross section

20. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
PGI2 (prostacyclin))
cancer arising from parafollicular C cells
G cells
Addison's

21. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
silver stain of gram negative rods
erythema nodosum
thayer martin media
sarcoma botyroides

22. Invasive ductal CA
brain tumor with foamy cells and high vascularity
most common breast mass in postmenopausal women
lewy body composition
midshaft break of humerus

23. Schwann cells
whats the V/Q at the base of the lung
lysosomal storage disease a/w renal disease
myelinates multiple CNS axons
myelinates on PNS

24. Somatostatin
UMN signs
what checkpoint is p53 involved with?
anti - platelet antibodies
D cells

25. HTN; masculinization
drug induced lupus
oligodendrioglia
11 beta hydroxylase deficiency
sarcoma botyroides

26. Yolk sac
most common testicular tumor in infants and children up to 3 years of age
what meds treat malaria
opioids antidote
catalase negative

27. Criglar Najar
honey crusted lesions common around nose/lips
polyhydramnios
absent UTPGT
brenner tumor

28. Aplastic anemia - rash - agranulocytosis
most common breast tumor in women under 25
propylthiouracil side effects
Where does the dorsal column decussate?
most common breast cancer

29. Fibrates/statins
SE: elevated LFTS - myositis
Lateral geniculate nucleus
thymidylate synthase
macrolides use (PUS)

30. Decreased follicles & estrogen with increased FSH & LH
What artery causes locked in syndrome
thromboxane A2
barbituates withdrawal
What are the hormone changes seen in menopause

31. Pacinian
what nerve innervates the muscles of mastication?
tram - track on microscope
resembles an onion in cross section
testicular tumor that can present with gynecomastia

32. SCID
child with eczema - coarse facial features - cold abscesses
lysosomal storage disease a/w renal disease
GABA - glutamine
currant jelly stool

33. Pemphigus vulgaris
t - PA - streptokinase antidote
HELLP syndrome
what meds treat malaria
anti - epithelial antibodies

34. Gilberts
mildly decreased UDPGT
What oncogene is a/w MEN 2a/b
LMN signs
lisch nodules

35. Panacinar
ovarian tumor with psammoma bodies
alpha 1 anti - trypsin
copper - arsenic - gold antidote
hep B seropositivity in 30% of patients

36. Norepinephrine
locus ceruleus
cancer associated with Hashimoto's thyroiditis
looks like fried eggs under histologic staining
VA/VL

37. Trigeminal
cause of low pH vaginal discharge
sumatriptan
what nerve innervates the muscles of mastication?
chief cells

38. Ach
erythema nodosum
gram + bacteria that requires NAD and hemin for growth
GABA - glutamine
basal nucleus of Meynert

39. Estrogen
SE: facial flushing
Bisphosphonates MofA
cause of LH surge
5 alpha reductase deficiency

40. Dubin Johnson
MofA of N- aceylcysteine
most common gyno malignancy
partial mole components
grossly black liver

41. 6- MP
cause of increased myometrial excitability
drug that blocks purine synthesis and is metabolized by xanthine oxidase
inheritance pattern for all MENs
most common testicular tumor

42. Cells of BBB
contains ovarian vessels
pseudopalisading necrosis
colchicine
astrocytes

43. Macrophages of the CNS
hydatidiform mole with crazy high hCG
brain tumor a/w von hipple - linadu syndrome
17 alpha hydroxylase deficiency
microglia

44. Hunters
3 tumors of MEN 2b
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
iduronidase sulfatase
neutrophils fail to respond to chemotaxic stimuli

45. Staph epidermidis - staph sapro
catalase positive coagulase negative
master clock for circadian rhythms
benzos antidote
chromosome 4

46. Decreased efficacy - decreased Vmax
eczema/recurrent infections/thrombocytopenia
absent UTPGT
polyhydramnios
dose response curve with noncompetitive antagonist

47. Gauchers
resembles an onion in cross section
crinkled paper cytoplasm
cells destroyed in Guillain Barre
strawberry tongue

48. Gauchers
S cells
diphtheria treatment
most common lysosomal storage disease
what cells secrete somatostatin

49. 0.6
most common bacteria in GI tract
Conn's syndrome
whats the V/Q at the base of the lung
dose response curve with noncompetitive antagonist

50. Glucuronyl transferase
TZD (glitazones) MofA
pseudopalisading necrosis
kluver bucy
enzyme used to conjugate bilirubin