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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Estrogen
cause of LH surge
21 hydroxylase deficiency
myelinates multiple CNS axons
Galactocerebrosidase deficiency

2. Glucuronyl transferase
sumatriptan
P450 Inhibitors
enzyme used to conjugate bilirubin
sturge weber syndrome

3. Increased acini and intralobular fibrosis
medial geniculate nucleus
what checkpoint is p53 involved with?
blocks ADP receptors to inhibit platelet aggregation
sclerosing adenosis

4. Autosomal dominant
gram + bacteria that requires NAD and hemin for growth
most common first line agent for septic shock
Abciximab
inheritance pattern for all MENs

5. Homocystienuria - Marfans
subluxation of lens
SE: elevated LFTS - myositis
partial mole components
hippocampus

6. Bilateral renal agenesis or posterior urethral valves in males
solitarius nucleus
oligohydramnios
3 tumors of MEN 2b
schwann cells

7. Tay SaX
best effect on HDL
which nerve lifts the eyelid?
mitral valve prolapse - liver diseae - berry aneurysm
heXosaminidase

8. Hemangioblastoma
best effect of triglycerides/VLDL
enzyme used to conjugate bilirubin
brain tumor with foamy cells and high vascularity
ambiguous nucleus

9. Panacinar
alpha 1 anti - trypsin
3 tumors of MEN 2a
Lewy bodies composition
kluver bucy

10. Streptococcus
brain tumor with fried egg appearance
vasculitis of infants and children - involving coronary arteries
catalase negative
plenta accreta

11. Estrogen
neutrophils fail to respond to chemotaxic stimuli
hallmark sign of COPD
cause of increased myometrial excitability
HELLP syndrome

12. Decreased follicles & estrogen with increased FSH & LH
What are the hormone changes seen in menopause
infliximab
Bisphosphonates MofA
most common breast tumor in women under 25

13. NE
resembles an onion in cross section
deficiency of mannose phosphorylation
child with eczema - coarse facial features - cold abscesses
most common first line agent for septic shock

14. H. Influenza
lysosomal storage disease - demyelinating disease
gram + bacteria that requires NAD and hemin for growth
first line for cardiogenic shock
UMN signs

15. Hurlers
alpha L iduronidase
contains ovarian vessels
VA/VL
TZD (glitazones) MofA

16. Seborric keratosis
neutrophils fail to respond to chemotaxic stimuli
keratin filled cysts
preeclampsia
S cells

17. Parathyroid - pituitary - pancreatic
metformin side effect
Where does the dorsal column decussate?
blocks ADP receptors to inhibit platelet aggregation
3 tumors of MEN 1

18. Auditory (Medial for Music)
GFAP positive
hippocampus
first line for cardiogenic shock
medial geniculate nucleus

19. Anti - TNF antibody - use for RA but watch out for latent TB!
infliximab
whats the V/Q at the apex of the lung
tumor composed of cytotrophoblasts and syncytiotrophoblasts
inheritance pattern for all MENs

20. Complete
beta glucocerebrosidase
what meds treat malaria
hydatidiform mole with crazy high hCG
sphingomyelinase deficiency

21. Hurlers - Hunters
cause of increased myometrial excitability
enzyme used to conjugate bilirubin
dermatin sulfate accumulation
child with eczema - coarse facial features - cold abscesses

22. Premature detachment of placenta - painful bleeding in 3rd trimester
SE: torsades de pointes
abruptio placentae
sarcoma botyroides
mitral valve prolapse - liver diseae - berry aneurysm

23. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
cells destroyed in MS
colchicine
hallmark sign of COPD
basal nucleus of Meynert

24. Pemphigus vulgaris
heparin antidote
17 alpha hydroxylase deficiency
plenta accreta
anti - epithelial antibodies

25. Membranoproliferative GN
sclerosing adenosis
tram - track on microscope
fusion inhibitors
FGFR3 mutation

26. Medulla
catalase negative
Where does the lateral corticospinal decussate?
sulfonylureas side effect
opioid withdrawal

27. B. fragilis
most common bacteria in GI tract
epithelial
thromboxane A2
D cells

28. Attachment of placenta to lower uterine segment
mitral valve prolapse - liver diseae - berry aneurysm
vasculitis a/w Hep B
paraventricular nucleus of hypothalamus
placenta previa

29. Somatostatin
D cells
What thyroid pathology has an extremely tender thyroid gland
midshaft break of humerus
first line for absence seizures

30. Damaged in multiple sclerosis
oligodendrioglia
Galactocerebrosidase deficiency
hemangioblastomas of retina/cerebellum/medulla
LTB4

31. HTN; XY will be a girl - XX will lack secondary sex char.
17 alpha hydroxylase deficiency
ambiguous nucleus
which nerve lifts the eyelid?
inheritance pattern for all MENs

32. CCK
schwann cells
I cells
sturge weber syndrome
VA/VL

33. Oligodendrogila
cells destroyed in MS
most common first line agent for septic shock
melanoma tumor marker
what cells secrete somatostatin

34. D cells of pancreas and gut
sturge weber syndrome
honey crusted lesions common around nose/lips
psammoma bodies
what cells secrete somatostatin

35. Fibroadenoma
ependymal cells
whats the V/Q at the base of the lung
most common breast tumor in women under 25
kluver bucy

36. Motor innervation of pharynx - larynx and upper esophagus
sulfonylureas side effect
tumor with call - exner bodies
ambiguous nucleus
blood supply for thalamus

37. Dubin Johnson
P450 Inhibitors
chief cells
grossly black liver
form multinucleated giant cells in the CNS when infected with HIV

38. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
shown to slow progression of diabetic neuropathy
sulfonylureas MofA
pseudopalisading necrosis
brain tumor with perivascular pseudorosettes

39. Combo of inhaled anesthetics & succinylcholine
cause of malignant hyperthermia
treatment of malignant hyperthermia
most common testicular tumor
lead antidote

40. Astrocytoma & glioblastoma multiforme
GFAP positive
sphingomyelinase deficiency
protease inhibitors MofA
opioids antidote

41. Leydig cell tumor
most common breast mass in pre - menopausal women
cause of low pH vaginal discharge
testicular tumor that can present with gynecomastia
most common gyno malignancy

42. Trichomonas - Giardia
most common breast tumor in women under 25
What are the hormone changes seen in menopause
oligodendrioglia
most common protozoal infection in US

43. Radial nerve - deep brachial artery
brain tumor a/w von hipple - linadu syndrome
most common breast mass in pre - menopausal women
midshaft break of humerus
lysosomal storage disease a/w renal disease

44. Motor
smoking emphysema
schwann cells
VA/VL
Lateral geniculate nucleus

45. Trichomonas or bacterial vaginosis
keratin filled cysts
brenner tumor
GM2 ganglioside accumulation
cause of high pH vaginal discharge

46. Kawasaki
kawasaki
BCG PQRS
Galactocerebrosidase deficiency
vasculitis of infants and children - involving coronary arteries

47. Bruton's agammaglobulinemia
Aschoff bodies
defective tyrosine kinase
order of nerve blockade
drug induced lupus

48. Suspensory ligament of ovaries
what nerve innervates the muscles of mastication?
contains ovarian vessels
hemosiderinurea and thrombosis
What causes coronary vasospasm as a SE?

49. Hunters
21 hydroxylase deficiency
iduronidase sulfatase
protease inhibitors MofA
catalase positive coagulase negative

50. Von Hippel Lindau
spike and dome on microscope
hemangioblastomas of retina/cerebellum/medulla
probenecid
contains ovarian vessels