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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Dopamine
5 alpha reductase deficiency
Where does the lateral corticospinal decussate?
keratin filled cysts
MPTP exposure causes depletion of what NT?

2. S-100
epithelial
melanoma tumor marker
partial mole components
intranuclear inclusions seen in herpes simplex encephalitis

3. Primary biliary cirrhosis
iduronidase sulfatase
treatment of malignant hyperthermia
branching rods on oral infection
anti - mitochondrial antibodies

4. Basilar
FGFR3 mutation
What artery causes locked in syndrome
Lewy bodies composition
blocks ADP receptors to inhibit platelet aggregation

5. Panacinar
Yolk sac tumor produces...
benzos antidote
lisch nodules
alpha 1 anti - trypsin

6. Secretin
S cells
sclerosing adenosis
what nerve innervates the muscles of mastication?
beta glucocerebrosidase

7. Inhibits viral assembly
What artery causes locked in syndrome
most common breast mass in postmenopausal women
protease inhibitors MofA
inheritance pattern for all MENs

8. Alpha synuclein
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
Lewy bodies composition
ependymal cells
whats the V/Q at the base of the lung

9. Chronic gout. inhibits reabsorbtion of uric acid in PCT
partial mole components
adenomyosis
probenecid
Galactocerebrosidase deficiency

10. Estrogen
child with eczema - coarse facial features - cold abscesses
infliximab
cause of increased myometrial excitability
3 tumors of MEN 2b

11. Flumazenil
sulfonylureas side effect
tumor with call - exner bodies
drug induced lupus
benzos antidote

12. Intrinsic factor
parietal cells
SE: elevated LFTS - myositis
basal nucleus of Meynert
failure of endodermal development

13. Oculomotor
which nerve lifts the eyelid?
may lead to multiple personalities
ependymal cells
ventral posterior nucleus - lateral part

14. Criglar Najar
leydig cell tumor
sclerosing adenosis
partial mole components
absent UTPGT

15. 6- mecaptopurine (metabolized by xanthine oxidase)
GABA - glutamine
HELLP syndrome
bocks PRPP synthetase to block purine synthesis
most common lysosomal storage disease

16. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
LT C4 D4 E4
hydatidiform mole with crazy high hCG
treatment for SIADH
x- linked recessive lysosomal storage diseases

17. Cells of BBB
astrocytes
homer wright rosettes
raphe nucleus
chief cells

18. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
brain tumor with fried egg appearance
vasculitis of infants and children - involving coronary arteries
SICK PEG
What thyroid pathology has an extremely tender thyroid gland

19. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
PGI2 (prostacyclin))
iduronidase sulfatase
grossly black liver
GFAP positive

20. Decreased FEV/FVC ratio
Where does the lateral corticospinal decussate?
partial mole components
astrocytes
hallmark sign of COPD

21. Oligodendoglia
myelinates multiple CNS axons
brain tumor with perivascular pseudorosettes
most common bacteria in GI tract
sphingomyelinase deficiency

22. ACE inhibitors
What causes coronary vasospasm as a SE?
shown to slow progression of diabetic neuropathy
HELLP syndrome
mitral valve prolapse - liver diseae - berry aneurysm

23. Krabbe's
first line for absence seizures
granulosa cell tumor secretes what?
testicular tumor that can present with gynecomastia
Galactocerebrosidase deficiency

24. Membranoproliferative GN
Shigella
oligohydramnios
tram - track on microscope
silver stain of gram negative rods

25. Masculinization - hypovolemic shock
most common first line agent for septic shock
sarcoma botyroides
21 hydroxylase deficiency
cause of LH surge

26. Glioblastoma multiforme
child with eczema - coarse facial features - cold abscesses
pseudopalisading necrosis
ovarian tumor with elevate hCG
ovarian tumor with psammoma bodies

27. Motor
VA/VL
Where does the dorsal column decussate?
x- linked recessive lysosomal storage diseases
form multinucleated giant cells in the CNS when infected with HIV

28. Cause release of preformed insulin
macrolides use (PUS)
sulfonylureas
Abciximab
hep B seropositivity in 30% of patients

29. Wiscott - Aldrich
eczema/recurrent infections/thrombocytopenia
pigmented iris hamartomas - neural tumors
ependymal cells
cause of low pH vaginal discharge

30. Marfans
etanercept
basal nucleus of Meynert
ovarian tumor with elevate hCG
floppy mitral valve dissecting aortic aneurysm - berry aneurysm

31. Attachment of placenta to lower uterine segment
thayer martin media
Schiller Duval bodies
cells destroyed in Guillain Barre
placenta previa

32. Polyarteritis nodosa
best effect of triglycerides/VLDL
P450 Inhibitors
vasculitis a/w Hep B
branching rods on oral infection

33. Schwann cells
catalase positive coagulase negative
order of nerve blockade
cells destroyed in Guillain Barre
follicular

34. Vibration - pressure
pacinian
What thyroid pathology has an extremely tender thyroid gland
GM2 ganglioside accumulation
first line for cardiogenic shock

35. Posterior communicating - posterior cerebral - anterior choroidal arteries
hippocampus
blocks ADP receptors to inhibit platelet aggregation
S cells
blood supply for thalamus

36. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
kluver bucy
hallmark sign of COPD
melanoma tumor marker
erythema nodosum

37. Complete
deficiency of mannose phosphorylation
thymidylate synthase
thayer martin media
hydatidiform mole with crazy high hCG

38. Increases platelet aggregation and vasoconstriction
microglia
thromboxane A2
UMN signs
bocks PRPP synthetase to block purine synthesis

39. Choriocarcinoma or dysgerminoma
which nerve lifts the eyelid?
t - PA - streptokinase antidote
crinkled paper cytoplasm
ovarian tumor with elevate hCG

40. Niacin
SE: facial flushing
most common bacteria in GI tract
cells destroyed in Guillain Barre
branching rods on oral infection

41. Sends autonomic fibers to heart
corneal clouding & MR
D cells
dorsal motor nucleus
chromosome 4

42. Gonorrhea
inheritance pattern for all MENs
grossly black liver
thayer martin media
barbituates withdrawal

43. Trichomonas - Giardia
most common breast cancer
complete mole components
H. flu
most common protozoal infection in US

44. Ret
What oncogene is a/w MEN 2a/b
gram + bacteria that requires NAD and hemin for growth
What hormones share a common alpha subunit
brenner tumor

45. Glutamate
testicular tumor that can present with gynecomastia
Conn's syndrome
Galactocerebrosidase deficiency
precursor to GABA

46. 6- MP
defective tyrosine kinase
brain tumor with fried egg appearance
rabies
drug that blocks purine synthesis and is metabolized by xanthine oxidase

47. Fabry's
grossly black liver
lysosomal storage disease a/w renal disease
heparin antidote
drug induced lupus

48. Macrolides
low dose ASA effects - intermediate dose - high dose
myelinates on PNS
what meds treat malaria
antibiotic with SE of eosinophilia

49. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
plenta accreta
opioids antidote
placenta previa
kawasaki

50. Von Hippel Lindau
SE: elevated LFTS - myositis
hemangioblastomas of retina/cerebellum/medulla
21 hydroxylase deficiency
catalase positive coagulase negative