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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Penicillamine
What oncogene is a/w MEN 2a/b
Lateral geniculate nucleus
copper - arsenic - gold antidote
most common breast mass in postmenopausal women

2. Dopamine
5 alpha reductase deficiency
hemosiderinurea + thrombosis
MPTP exposure causes depletion of what NT?
Aschoff bodies

3. Hurlers
Conn's syndrome
corneal clouding & MR
t - PA - streptokinase antidote
alpha L iduronidase

4. Granulosa cell tumor
lysosomal storage disease - demyelinating disease
tumor with call - exner bodies
iduronidase sulfatase
placenta previa

5. Marfans
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
child with partial albinism - peripherial neuropathy - recurrent infections
whats the V/Q at the base of the lung
enzyme used to conjugate bilirubin

6. Premature detachment of placenta - painful bleeding in 3rd trimester
Lateral geniculate nucleus
GM2 ganglioside accumulation
abruptio placentae
pigmented iris hamartomas - neural tumors

7. Prazosin
bocks PRPP synthetase to block purine synthesis
vasculitis a/w Hep B
SE: elevated LFTS - myositis
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

8. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
which nerve lifts the eyelid?
heXosaminidase
psammoma bodies
drug induced lupus

9. Chediak - Higashi
abruptio placentae
5 alpha reductase deficiency
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
child with partial albinism - peripherial neuropathy - recurrent infections

10. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
branching rods on oral infection
spike and dome on microscope
TZD (glitazones) MofA
most common bacteria in GI tract

11. Schwann cells
sulfonylureas side effect
G cells
cause of increased myometrial excitability
cells destroyed in Guillain Barre

12. Niacins
keratin filled cysts
best effect on HDL
deficiency of mannose phosphorylation
brain tumor a/w von hipple - linadu syndrome

13. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
Where does the lateral corticospinal decussate?
precursor to GABA
3 tumors of MEN 2b
order of nerve blockade

14. BCG PQRS
neutrophils fail to respond to chemotaxic stimuli
alpha 1 anti - trypsin
most common first line agent for septic shock
P450 inducers

15. Medulla
treatment of malignant hyperthermia
Where does the dorsal column decussate?
chromosome 4
cause of increased myometrial excitability

16. G1/S & G2/M
what checkpoint is p53 involved with?
sturge weber syndrome
fusion inhibitors
hemangioblastomas of retina/cerebellum/medulla

17. A few levels above the level of entry
metformin side effect
Where does the spinothalamic decussate?
anti - epithelial antibodies
VA/VL

18. Lymphoma

19. Protamine sulfate
heparin antidote
G cells
propylthiouracil side effects
vasculitis a/w Hep B

20. Chronic gout. inhibits reabsorbtion of uric acid in PCT
Conn's syndrome
probenecid
ependymal cells
looks like fried eggs under histologic staining

21. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
dermatin sulfate accumulation
drug induced lupus
sulfonylureas MofA
HELLP syndrome

22. Inhibits viral assembly
solitarius nucleus
branching rods on oral infection
eczema/recurrent infections/thrombocytopenia
protease inhibitors MofA

23. Hypoglycemia
basal nucleus of Meynert
sulfonylureas side effect
What oncogene is a/w MEN 2a/b
honey crusted lesions common around nose/lips

24. Trichomonas - Giardia
most common testicular tumor
infliximab
most common protozoal infection in US
what cells secrete somatostatin

25. Estrogen
midshaft break of humerus
what checkpoint is p53 involved with?
most common arrthymia
cause of LH surge

26. Macrophages of the CNS
microglia
Aschoff bodies
etanercept
testicular tumor that can present with gynecomastia

27. Pemphigus vulgaris
anti - epithelial antibodies
hemosiderinurea + thrombosis
drug induced lupus
What causes coronary vasospasm as a SE?

28. Dobutamine
first line for cardiogenic shock
honey crusted lesions common around nose/lips
GABA - glutamine
basal nucleus of Meynert

29. Ependymoma
defective tyrosine kinase
brain tumor with perivascular pseudorosettes
SICK PEG
LMN signs

30. Obstructive - COPD
GM2 ganglioside accumulation
solitarius nucleus
pt has extended expiratory phase
cells destroyed in Guillain Barre

31. Fibrates
best effect of triglycerides/VLDL
grossly black liver
S cells
t - PA - streptokinase antidote

32. Invasive ductal
most common breast cancer
follicular
myelinates on PNS
heXosaminidase

33. SCID
hallmark sign of COPD
ambiguous nucleus
child with eczema - coarse facial features - cold abscesses
dose response curve change with competitive antagonist

34. Ach
basal nucleus of Meynert
probenecid
meissners
mitral valve prolapse - liver diseae - berry aneurysm

35. Hairless skin - dynamic fine touch
hydatidiform mole with crazy high hCG
may lead to multiple personalities
3 tumors of MEN 2a
meissners

36. Yolk sac
BCG PQRS
most common testicular tumor in infants and children up to 3 years of age
optically clear nuclei (orphan annie)
sulfonylureas side effect

37. Dimercaprol
testicular tumor that can present with gynecomastia
solitarius nucleus
lead antidote
pt has extended expiratory phase

38. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
ovarian tumor that resembles bladder epithelium
heparin antidote
LTB4
sarcoma botyroides

39. Decreased potency - increased Km
copper - arsenic - gold antidote
most common breast mass in postmenopausal women
dose response curve change with competitive antagonist
inheritance pattern for all MENs

40. Ethosuximide
sumatriptan
diphtheria treatment
first line for absence seizures
solitarius nucleus

41. Superchiasmic nucleus
brain tumor a/w von hipple - linadu syndrome
Galactocerebrosidase deficiency
master clock for circadian rhythms
rate limiting step in carb digestion

42. Radial nerve - deep brachial artery
thromboxane A2
midshaft break of humerus
ventral posterior nucleus - medial part
looks like fried eggs under histologic staining

43. Pneumonia - URIs - STDS
macrolides use (PUS)
Lateral geniculate nucleus
HELLP syndrome
Addison's

44. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
plenta accreta
sarcoma botyroides
schwann cells
astrocytes

45. TSH - LH - FSH - hCG
sturge weber syndrome
thymidylate synthase
What hormones share a common alpha subunit
LTB4

46. TNF receptor
etanercept
cause of LH surge
solitarius nucleus
catalase positive coagulase negative

47. Memory
what meds treat malaria
precursor to GABA
catalase positive coagulase negative
hippocampus

48. Aminocaproic acid
found in hairless skin
GFAP positive
MofA of N- aceylcysteine
t - PA - streptokinase antidote

49. Gilberts
mildly decreased UDPGT
LTB4
honey crusted lesions common around nose/lips
ovarian tumor that resembles bladder epithelium

50. Fabry's
found in hairless skin
lysosomal storage disease a/w renal disease
vasculitis of infants and children - involving coronary arteries
D cells