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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Alpha feto protein
Yolk sac tumor produces...
honey crusted lesions common around nose/lips
most common first line agent for septic shock
most common protozoal infection in US

2. Babinski - weakness - increased reflexes & tone - spastic paralysis
3 tumors of MEN 2a
UMN signs
alpha 1 anti - trypsin
basal nucleus of Meynert

3. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
what inhibits prolactin secretion
sarcoma botyroides
barbituates withdrawal
PGI2 (prostacyclin))

4. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
catalase negative
meissners
TZD (glitazones) MofA
hemangioblastomas of retina/cerebellum/medulla

5. Leydig cell tumor
melanoma tumor marker
what meds treat malaria
alpha 1 anti - trypsin
testicular tumor that can present with gynecomastia

6. Visual (Lateral for Light)
3 tumors of MEN 1
Lateral geniculate nucleus
P450 Inhibitors
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

7. Chediak - Higashi
myelinates on PNS
opioid withdrawal
brenner tumor
child with partial albinism - peripherial neuropathy - recurrent infections

8. Fibrates
form multinucleated giant cells in the CNS when infected with HIV
best effect of triglycerides/VLDL
fusion inhibitors
solitarius nucleus

9. Hemangioblastoma
copper - arsenic - gold antidote
brain tumor with foamy cells and high vascularity
first line for absence seizures
honey crusted lesions common around nose/lips

10. HTN; masculinization
lisch nodules
von Hippel Lindau disease
11 beta hydroxylase deficiency
brain tumor with foamy cells and high vascularity

11. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
drug that blocks purine synthesis and is metabolized by xanthine oxidase
21 hydroxylase deficiency
drug induced lupus
ovarian tumor with psammoma bodies

12. Pneumonia - URIs - STDS
oligohydramnios
macrolides use (PUS)
enzyme used to conjugate bilirubin
treatment of malignant hyperthermia

13. Clopidogrel - ticoplidine
bocks PRPP synthetase to block purine synthesis
blocks ADP receptors to inhibit platelet aggregation
cause of LH surge
pigmented iris hamartomas - neural tumors

14. Ethosuximide
alpha L iduronidase
first line for absence seizures
meissners
sphingomyelinase deficiency

15. Achondroplasia
vasculitis a/w Hep B
S cells
FGFR3 mutation
von Hippel Lindau disease

16. Seminoma
low dose ASA effects - intermediate dose - high dose
most common testicular tumor
looks like fried eggs under histologic staining
SE: torsades de pointes

17. Basal cell carcinoma
cause of LH surge
pacinian
basal nucleus of Meynert
palisading nuclei - locally invasive

18. Actinomyces
P450 inducers
branching rods on oral infection
macrolides use (PUS)
Shigella

19. Medulla
Where does the lateral corticospinal decussate?
crinkled paper cytoplasm
thayer martin media
medial geniculate nucleus

20. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
sulfonylureas MofA
oligodendrioglia
supraoptic nucleus of hypothalamus
lysosomal storage disease a/w renal disease

21. Cant convert testosterone to DHT - ambiguous genitalia until puberty then penis at 12
resembles an onion in cross section
5 alpha reductase deficiency
heparin antidote
blocks ADP receptors to inhibit platelet aggregation

22. Inhibits osteoclastic activity
grossly black liver
Bisphosphonates MofA
FGFR3 mutation
branching rods on oral infection

23. 3
brenner tumor
whats the V/Q at the apex of the lung
S cells
UMN signs

24. Ovarian bengin tumor...looks like bladder
brenner tumor
cough - conjunctivitis - coryza - fever
FGFR3 mutation
microglia

25. Regenerates glutathione
G cells
Where does the spinothalamic decussate?
MofA of N- aceylcysteine
most common first line agent for septic shock

26. Staph epidermidis - staph sapro
branching rods on oral infection
abruptio placentae
P450 Inhibitors
catalase positive coagulase negative

27. Chronic gout. inhibits reabsorbtion of uric acid in PCT
melanoma tumor marker
von Hippel Lindau disease
what meds treat malaria
probenecid

28. H. Influenza
catalase positive coagulase negative
G cells
gram + bacteria that requires NAD and hemin for growth
homer wright rosettes

29. Actinomyces
VA/VL
chief cells
branching rods on oral infection
which nerve lifts the eyelid?

30. Meningioma
brain tumor with psammona bodies
anti - mitochondrial antibodies
blood supply for thalamus
partial mole components

31. Gonorrhea
schwann cells
SICK PEG
testicular tumor that can present with gynecomastia
thayer martin media

32. Von Hippel Lindau
most common primary cardiac tumor in kiddos
hemangioblastomas of retina/cerebellum/medulla
raphe nucleus
P450 inducers

33. Yolk sac
most common testicular tumor in infants and children up to 3 years of age
bocks PRPP synthetase to block purine synthesis
ventral posterior nucleus - medial part
intranuclear inclusions seen in herpes simplex encephalitis

34. Streptococcus
What thyroid pathology has an extremely tender thyroid gland
vasculitis of infants and children - involving coronary arteries
thromboxane A2
catalase negative

35. Huntingtons chorea
palisading nuclei - locally invasive
What artery causes locked in syndrome
chromosome 4
P450 Inhibitors

36. Ependymoma
brain tumor with perivascular pseudorosettes
hemangioblastomas of retina/cerebellum/medulla
antibody against philadelphia chromosome
Where does the dorsal column decussate?

37. Naloxone/naltrexone
strawberry tongue
SE: facial flushing
opioids antidote
leydig cell tumor

38. Benign - contains Reinke crystals - usually androgen producing
whats the V/Q at the apex of the lung
leydig cell tumor
heparin antidote
etanercept

39. Flumazenil
order of nerve blockade
benzos antidote
kawasaki
cells destroyed in Guillain Barre

40. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
MofA Levothyroxine
thromboxane A2
kawasaki
I cells

41. Alpha synuclein
hydrocele
what checkpoint is p53 involved with?
first line for absence seizures
lewy body composition

42. Brenners tumor
cause of LH surge
x- linked recessive lysosomal storage diseases
ovarian tumor that resembles bladder epithelium
thayer martin media

43. Fibrates/statins
most common first line agent for septic shock
SE: elevated LFTS - myositis
I cells
may lead to multiple personalities

44. Obstructive - COPD
brain tumor a/w von hipple - linadu syndrome
anti - epithelial antibodies
pt has extended expiratory phase
hallmark sign of COPD

45. Hairless skin - dynamic fine touch
basal nucleus of Meynert
meissners
lead antidote
inheritance pattern for all MENs

46. Hurlers
What causes coronary vasospasm as a SE?
LTB4
alpha L iduronidase
sphingomyelinase deficiency

47. Increased acini and intralobular fibrosis
eczema/recurrent infections/thrombocytopenia
3 tumors of MEN 2b
sclerosing adenosis
most common protozoal infection in US

48. Tay SaX
Where does the spinothalamic decussate?
cancer associated with Hashimoto's thyroiditis
heXosaminidase
contains ovarian vessels

49. Sotalol - quinidine - cisapride
meissners
hallmark sign of COPD
SE: torsades de pointes
placenta previa

50. Oligosaccaride hydrolase
follicular
locus ceruleus
rate limiting step in carb digestion
pacinian