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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Hereditary spherocytosis
What oncogene is a/w MEN 2a/b
low dose ASA effects - intermediate dose - high dose
increased MCHC and hemolytic anemia
locus ceruleus

2. Von Hippel Lindau
hemangioblastomas of retina/cerebellum/medulla
pigmented iris hamartomas - neural tumors
ependymal cells
sumatriptan

3. Demeclycocycline or water restriction
tram - track on microscope
treatment for SIADH
complete mole components
chromosome 4

4. Decreased FEV/FVC ratio
what meds treat malaria
hallmark sign of COPD
mildly decreased UDPGT
thyroid cancer associtated with RET oncogene

5. Astrocytoma & glioblastoma multiforme
What hormones share a common alpha subunit
brain tumor with psammona bodies
GFAP positive
what checkpoint is p53 involved with?

6. Fabrys
alpha galacosidase A
whats the V/Q at the apex of the lung
protease inhibitors MofA
cause of high pH vaginal discharge

7. Ependymoma
Lateral geniculate nucleus
thromboxane A2
master clock for circadian rhythms
brain tumor with perivascular pseudorosettes

8. Seborric keratosis
failure of endodermal development
keratin filled cysts
abruptio placentae
most common lysosomal storage disease

9. Combo of inhaled anesthetics & succinylcholine
low dose ASA effects - intermediate dose - high dose
cause of malignant hyperthermia
complete mole components
most common arrthymia

10. Cowdry type A inclusions
ovarian tumor with elevate hCG
intranuclear inclusions seen in herpes simplex encephalitis
preeclampsia
alpha galacosidase A

11. Fabry's & Hunters
x- linked recessive lysosomal storage diseases
antibiotic with SE of eosinophilia
dose response curve change with competitive antagonist
intranuclear inclusions seen in herpes simplex encephalitis

12. NE
Lewy bodies composition
locus ceruleus
opioid withdrawal
t - PA - streptokinase antidote

13. Serous cystadenocarcinoma
blocks ADP receptors to inhibit platelet aggregation
ovarian tumor with psammoma bodies
Aschoff bodies
x- linked recessive lysosomal storage diseases

14. PNH
UMN signs
hemosiderinurea and thrombosis
what nerve innervates the muscles of mastication?
benzos antidote

15. Hemolysis - elevated LFTs - Low Platelets
brain tumor with fried egg appearance
3 tumors of MEN 1
HELLP syndrome
Where does the dorsal column decussate?

16. Normal or candida
placenta previa
whats the V/Q at the base of the lung
cause of low pH vaginal discharge
Conn's syndrome

17. Gonorrhea
thayer martin media
treatment for SIADH
shown to slow progression of diabetic neuropathy
master clock for circadian rhythms

18. Hemangioblastoma
brain tumor a/w von hipple - linadu syndrome
ventral posterior nucleus - lateral part
sulfonylureas side effect
complete mole components

19. Hunters
keratin filled cysts
iduronidase sulfatase
sulfonylureas MofA
subluxation of lens

20. Cocain and sumatriptan
nucleoside reverse transcriptase inhibitors
ovarian tumor that resembles bladder epithelium
erythema nodosum
What causes coronary vasospasm as a SE?

21. Autosomal dominant
inheritance pattern for all MENs
ventral posterior nucleus - medial part
17 alpha hydroxylase deficiency
basal nucleus of Meynert

22. Kawasaki (treat with high dose aspirin)
strawberry tongue
cough - conjunctivitis - coryza - fever
FGFR3 mutation
most common arrthymia

23. Inner lining of ventricles - make CSF - originate from neuroectoderm
Galactocerebrosidase deficiency
dorsal motor nucleus
cause of LH surge
ependymal cells

24. Masculinization - hypovolemic shock
21 hydroxylase deficiency
schwann cells
antibiotic with SE of eosinophilia
mildly decreased UDPGT

25. Body sensation
3 tumors of MEN 2a
brain tumor with foamy cells and high vascularity
rate limiting step in carb digestion
ventral posterior nucleus - lateral part

26. Penicillamine
ventral posterior nucleus - medial part
most common breast cancer
copper - arsenic - gold antidote
GFAP positive

27. Attachment of placenta to lower uterine segment
placenta previa
form multinucleated giant cells in the CNS when infected with HIV
epithelial
subluxation of lens

28. Ovarian bengin tumor...looks like bladder
alpha L iduronidase
brenner tumor
MPTP exposure causes depletion of what NT?
iduronidase sulfatase

29. Norepinephrine
locus ceruleus
PGI2 (prostacyclin))
which nerve lifts the eyelid?
enzyme used to conjugate bilirubin

30. Deficiency of aldosterone and cortisol

31. Memory
what inhibits prolactin secretion
most common arrthymia
most common breast tumor in women under 25
hippocampus

32. Protamine sulfate
beta glucocerebrosidase
heparin antidote
abruptio placentae
HELLP syndrome

33. Regenerates glutathione
myelinates multiple CNS axons
MofA of N- aceylcysteine
Abciximab
SE: elevated LFTS - myositis

34. Auditory (Medial for Music)
sphingomyelinase deficiency
medial geniculate nucleus
most common breast tumor in women under 25
3 tumors of MEN 2b

35. Dubin Johnson
pseudopalisading necrosis
grossly black liver
testicular tumor that can present with gynecomastia
11 beta hydroxylase deficiency

36. Ethosuximide
first line for absence seizures
3 tumors of MEN 2a
ventral posterior nucleus - medial part
grossly black liver

37. SCID
enzyme used to conjugate bilirubin
child with eczema - coarse facial features - cold abscesses
barbituates withdrawal
What thyroid pathology has an extremely tender thyroid gland

38. Decreases conversion
lewy body composition
What hormones share a common alpha subunit
found in hairless skin
PTU

39. Suspensory ligament of ovaries
granulosa cell tumor secretes what?
brenner tumor
What hormones share a common alpha subunit
contains ovarian vessels

40. Endometrial glands inside myometrium
vasculitis of infants and children - involving coronary arteries
adenomyosis
5 alpha reductase deficiency
nucleoside reverse transcriptase inhibitors

41. HTN - proteinuria - edema
alpha L iduronidase
preeclampsia
SICK PEG
paraventricular nucleus of hypothalamus

42. Anxiety - seizures - delirium - life threatening CV collapse
barbituates withdrawal
hep B seropositivity in 30% of patients
Where does the spinothalamic decussate?
enzyme used to conjugate bilirubin

43. Streptococcus
catalase negative
Lewy bodies composition
What hormones share a common alpha subunit
17 alpha hydroxylase deficiency

44. Pneumonia - URIs - STDS
midshaft break of humerus
SICK PEG
macrolides use (PUS)
ambiguous nucleus

45. Yolk sac
locus ceruleus
locus ceruleus
HELLP syndrome
most common testicular tumor in infants and children up to 3 years of age

46. Premature detachment of placenta - painful bleeding in 3rd trimester
psammoma bodies
cells destroyed in Guillain Barre
abruptio placentae
form multinucleated giant cells in the CNS when infected with HIV

47. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
pseudopalisading necrosis
palisading nuclei - locally invasive
BCG PQRS
nucleoside reverse transcriptase inhibitors

48. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
pt has extended expiratory phase
oligodendrioglia
ovarian tumor that resembles bladder epithelium
TZD (glitazones) MofA

49. Choriocarcinoma
tumor composed of cytotrophoblasts and syncytiotrophoblasts
astrocytes
deficiency of mannose phosphorylation
most common lysosomal storage disease

50. Cell type involved in most ovarian tumors
brain tumor with fried egg appearance
treatment for SIADH
alpha L iduronidase
epithelial