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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
What artery causes locked in syndrome
medial geniculate nucleus
silver stain of gram negative rods
astrocytes

2. Dopamine
MPTP exposure causes depletion of what NT?
ovarian tumor with elevate hCG
What thyroid pathology has an extremely tender thyroid gland
Bisphosphonates MofA

3. Hypoglycemia
t - PA - streptokinase antidote
sulfonylureas side effect
Where does the lateral corticospinal decussate?
enzyme used to conjugate bilirubin

4. TSH - LH - FSH - hCG
What hormones share a common alpha subunit
partial mole components
oligohydramnios
placenta previa

5. Secretin
adenomyosis
thayer martin media
S cells
opioid withdrawal

6. Body sensation
ventral posterior nucleus - lateral part
mitral valve prolapse - liver diseae - berry aneurysm
Conn's syndrome
raphe nucleus

7. Dobutamine
first line for cardiogenic shock
most common protozoal infection in US
locus ceruleus
propylthiouracil side effects

8. Hurlers - Hunters
dermatin sulfate accumulation
tram - track on microscope
diphtheria treatment
child with partial albinism - peripherial neuropathy - recurrent infections

9. Yolk sac tumor
Schiller Duval bodies
tumor with call - exner bodies
kluver bucy
cause of increased myometrial excitability

10. Hairless skin - dynamic fine touch
thyroid cancer associtated with RET oncogene
hemosiderinurea + thrombosis
SE: torsades de pointes
meissners

11. CCK
macrolides use (PUS)
etanercept
I cells
ovarian tumor with elevate hCG

12. Most common type of thyroid cancer
papillary thyroid cancer
hydatidiform mole with crazy high hCG
smoking emphysema
eczema/recurrent infections/thrombocytopenia

13. Autosomal dominant
cancer arising from parafollicular C cells
inheritance pattern for all MENs
sturge weber syndrome
hydatidiform mole with crazy high hCG

14. Tay Sachs
GM2 ganglioside accumulation
What artery causes locked in syndrome
neutrophils fail to respond to chemotaxic stimuli
which nerve lifts the eyelid?

15. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
myelinates multiple CNS axons
low dose ASA effects - intermediate dose - high dose
cells destroyed in Guillain Barre
hep B seropositivity in 30% of patients

16. Prevents incorporation into host DNA
granulosa cell tumor secretes what?
nucleoside reverse transcriptase inhibitors
etanercept
TZD (glitazones) MofA

17. Gastrin
intranuclear inclusions seen in herpes simplex encephalitis
MofA of N- aceylcysteine
G cells
which nerve lifts the eyelid?

18. Estrogen
11 beta hydroxylase deficiency
cause of LH surge
pseudopalisading necrosis
benzos antidote

19. A/w esophageal/duodenal atresia and anencephaly
most common protozoal infection in US
polyhydramnios
cause of increased myometrial excitability
mildly decreased UDPGT

20. Meningioma
most common protozoal infection in US
resembles an onion in cross section
brain tumor with psammona bodies
myelinates on PNS

21. Kawasaki (treat with high dose aspirin)
sulfonylureas MofA
pseudopalisading necrosis
defective tyrosine kinase
strawberry tongue

22. Achondroplasia
drug that blocks purine synthesis and is metabolized by xanthine oxidase
vasculitis of infants and children - involving coronary arteries
Lateral geniculate nucleus
FGFR3 mutation

23. Subacute (De Quervain's) thyroiditis
What thyroid pathology has an extremely tender thyroid gland
follicular
Where does the lateral corticospinal decussate?
enzyme used to conjugate bilirubin

24. Oligodendroglia
looks like fried eggs under histologic staining
MofA of N- aceylcysteine
thayer martin media
subluxation of lens

25. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
3 tumors of MEN 2b
ovarian tumor with elevate hCG
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
metformin side effect

26. Radial nerve - deep brachial artery
tumor composed of cytotrophoblasts and syncytiotrophoblasts
brenner tumor
midshaft break of humerus
5 alpha reductase deficiency

27. Macrolides
precursor to GABA
melanoma tumor marker
most common gyno malignancy
antibiotic with SE of eosinophilia

28. Increased acini and intralobular fibrosis
sclerosing adenosis
cause of malignant hyperthermia
basal nucleus of Meynert
protease inhibitors MofA

29. Sotalol - quinidine - cisapride
medial geniculate nucleus
adenomyosis
SE: torsades de pointes
crinkled paper cytoplasm

30. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
cause of malignant hyperthermia
opioids antidote
sulfonylureas MofA
whats the V/Q at the base of the lung

31. Invasive ductal
enzyme used to conjugate bilirubin
von Hippel Lindau disease
diphtheria treatment
most common breast cancer

32. ACE inhibitors
eczema/recurrent infections/thrombocytopenia
shown to slow progression of diabetic neuropathy
11 beta hydroxylase deficiency
3 tumors of MEN 2a

33. Bind viral gp41 subunit
dermatin sulfate accumulation
LTB4
fusion inhibitors
thyroid cancer associtated with RET oncogene

34. Staph epidermidis - staph sapro
catalase positive coagulase negative
nucleoside reverse transcriptase inhibitors
TZD (glitazones) MofA
oligohydramnios

35. Glioblastoma multiforme
heXosaminidase
most common testicular tumor in infants and children up to 3 years of age
benzos antidote
pseudopalisading necrosis

36. Regenerates glutathione
SE: facial flushing
fusion inhibitors
MofA of N- aceylcysteine
paraventricular nucleus of hypothalamus

37. Posterior communicating - posterior cerebral - anterior choroidal arteries
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
blood supply for thalamus
most common testicular tumor
lysosomal storage disease a/w renal disease

38. Trichomonas - Giardia
most common protozoal infection in US
metformin side effect
t - PA - streptokinase antidote
Bisphosphonates MofA

39. 0.6
whats the V/Q at the base of the lung
SE: torsades de pointes
P450 Inhibitors
alpha galacosidase A

40. Streptococcus
catalase negative
SE: torsades de pointes
lisch nodules
found in hairless skin

41. Estrogen
first line for cardiogenic shock
basal nucleus of Meynert
lead antidote
cause of increased myometrial excitability

42. B. fragilis
melanoma tumor marker
most common bacteria in GI tract
brenner tumor
G cells

43. Cowdry type A inclusions
best effect on HDL
best effect of triglycerides/VLDL
antibiotic with SE of eosinophilia
intranuclear inclusions seen in herpes simplex encephalitis

44. SICK PEG
sturge weber syndrome
melanoma tumor marker
optically clear nuclei (orphan annie)
P450 Inhibitors

45. Huntingtons chorea
branching rods on oral infection
LT C4 D4 E4
chromosome 4
lisch nodules

46. Medulla
Galactocerebrosidase deficiency
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
Where does the dorsal column decussate?
order of nerve blockade

47. Prazosin
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
ependymal cells
5 alpha reductase deficiency
ovarian tumor with elevate hCG

48. Alpha synuclein
SE: elevated LFTS - myositis
What causes coronary vasospasm as a SE?
lewy body composition
ovarian tumor with elevate hCG

49. Alpha synuclein
SICK PEG
abruptio placentae
Lewy bodies composition
sumatriptan

50. Serotonin
astrocytes
Galactocerebrosidase deficiency
raphe nucleus
Where does the spinothalamic decussate?