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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Serotonin
raphe nucleus
Galactocerebrosidase deficiency
anti - epithelial antibodies
lysosomal storage disease - demyelinating disease

2. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
SE: torsades de pointes
optically clear nuclei (orphan annie)
midshaft break of humerus
BCG PQRS

3. Cocain and sumatriptan
increased MCHC and hemolytic anemia
may lead to multiple personalities
silver stain of gram negative rods
What causes coronary vasospasm as a SE?

4. Hurlers - Hunters
dermatin sulfate accumulation
tram - track on microscope
branching rods on oral infection
placenta previa

5. Antibody binds to gp2b/3a - preventing aggregation
preeclampsia
inheritance pattern for all MENs
Abciximab
ventral posterior nucleus - medial part

6. Actinomyces
melanoma tumor marker
tram - track on microscope
brain tumor with perivascular pseudorosettes
branching rods on oral infection

7. Medullary thyroid - pheochromocytoma - parathryoid
3 tumors of MEN 2a
anti - platelet antibodies
increased MCHC and hemolytic anemia
midshaft break of humerus

8. Decreased follicles & estrogen with increased FSH & LH
treatment of malignant hyperthermia
pacinian
most common gyno malignancy
What are the hormone changes seen in menopause

9. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
dorsal motor nucleus
failure of endodermal development
colchicine
parietal cells

10. SCID
ovarian tumor that resembles bladder epithelium
epithelial
child with eczema - coarse facial features - cold abscesses
eczema/recurrent infections/thrombocytopenia

11. HTN - proteinuria - edema
LT C4 D4 E4
preeclampsia
catalase positive coagulase negative
barbituates withdrawal

12. Memory
thromboxane A2
anti - epithelial antibodies
hippocampus
Lateral geniculate nucleus

13. Masculinization - hypovolemic shock
optically clear nuclei (orphan annie)
placenta previa
H. flu
21 hydroxylase deficiency

14. Brenners tumor
ovarian tumor that resembles bladder epithelium
hallmark sign of COPD
sarcoma botyroides
complete mole components

15. Seborric keratosis
keratin filled cysts
palisading nuclei - locally invasive
tumor composed of cytotrophoblasts and syncytiotrophoblasts
dorsal motor nucleus

16. Primary biliary cirrhosis
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
anti - mitochondrial antibodies
17 alpha hydroxylase deficiency
lisch nodules

17. Fibroadenoma
most common breast tumor in women under 25
master clock for circadian rhythms
currant jelly stool
child with partial albinism - peripherial neuropathy - recurrent infections

18. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
LT C4 D4 E4
branching rods on oral infection
meissners
dermatin sulfate accumulation

19. Pepsin
11 beta hydroxylase deficiency
supraoptic nucleus of hypothalamus
Conn's syndrome
chief cells

20. Impetigo
anti - mitochondrial antibodies
spike and dome on microscope
diphtheria treatment
honey crusted lesions common around nose/lips

21. Medullary
cancer associated with Hashimoto's thyroiditis
GFAP positive
cancer arising from parafollicular C cells
brenner tumor

22. Alpha feto protein
Yolk sac tumor produces...
copper - arsenic - gold antidote
cause of low pH vaginal discharge
kluver bucy

23. A few levels above the level of entry
Where does the spinothalamic decussate?
anti - epithelial antibodies
child with partial albinism - peripherial neuropathy - recurrent infections
basal nucleus of Meynert

24. Niemann Pick
lysosomal storage disease - demyelinating disease
11 beta hydroxylase deficiency
MofA Levothyroxine
sphingomyelinase deficiency

25. Combo of inhaled anesthetics & succinylcholine
3 tumors of MEN 2a
cause of malignant hyperthermia
crinkled paper cytoplasm
grossly black liver

26. Wiscott - Aldrich
eczema/recurrent infections/thrombocytopenia
macrolides use (PUS)
pigmented iris hamartomas - neural tumors
first line for absence seizures

27. Cavernous hemangiomas in skin - mucosa & organs; autosomal dominant - a/w renal CA - hemangioblastoma in retina - brainstem & cerebellum
lisch nodules
sphingomyelinase deficiency
von Hippel Lindau disease
honey crusted lesions common around nose/lips

28. Polyarteritis nodosa
brain tumor a/w von hipple - linadu syndrome
hep B seropositivity in 30% of patients
etanercept
eczema/recurrent infections/thrombocytopenia

29. 2 sperm + empty egg (no fetal parts)
complete mole components
dose response curve with noncompetitive antagonist
macrolides use (PUS)
lysosomal storage disease a/w renal disease

30. 5- fluorouracil
thymidylate synthase
deficiency of mannose phosphorylation
brain tumor with perivascular pseudorosettes
MPTP exposure causes depletion of what NT?

31. Chediak - Higashi
papillary thyroid cancer
brenner tumor
honey crusted lesions common around nose/lips
child with partial albinism - peripherial neuropathy - recurrent infections

32. Trichomonas or bacterial vaginosis
G cells
tumor with call - exner bodies
cause of high pH vaginal discharge
hemangioblastomas of retina/cerebellum/medulla

33. Krabbe's
most common protozoal infection in US
best effect on HDL
Galactocerebrosidase deficiency
brain tumor with fried egg appearance

34. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
sumatriptan
antibiotic with SE of eosinophilia
catalase negative
PGI2 (prostacyclin))

35. Antitoxin - penicillin - DPT vaccine
diphtheria treatment
tumor with call - exner bodies
lead antidote
heXosaminidase

36. Prevents incorporation into host DNA
testicular tumor that can present with gynecomastia
child with eczema - coarse facial features - cold abscesses
nucleoside reverse transcriptase inhibitors
cells destroyed in MS

37. Vibration - pressure
pacinian
whats the V/Q at the base of the lung
most common protozoal infection in US
BCG PQRS

38. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
3 tumors of MEN 2b
whats the V/Q at the base of the lung
11 beta hydroxylase deficiency
gram + bacteria that requires NAD and hemin for growth

39. Staph epidermidis - staph sapro
tumor with call - exner bodies
catalase positive coagulase negative
treatment of malignant hyperthermia
eczema/recurrent infections/thrombocytopenia

40. Fabry's
lysosomal storage disease a/w renal disease
resembles an onion in cross section
what meds treat malaria
What hormones share a common alpha subunit

41. Visceral sensory
solitarius nucleus
von Hippel Lindau disease
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
anti - platelet antibodies

42. Protamine sulfate
low dose ASA effects - intermediate dose - high dose
heparin antidote
kluver bucy
follicular

43. Bruton's agammaglobulinemia
defective tyrosine kinase
hemosiderinurea and thrombosis
erythema nodosum
PTU

44. Papillary CA of thyroid
optically clear nuclei (orphan annie)
corneal clouding & MR
11 beta hydroxylase deficiency
GFAP positive

45. Dissociative
inheritance pattern for all MENs
sarcoma botyroides
contains ovarian vessels
may lead to multiple personalities

46. SICK PEG
P450 Inhibitors
antibody against philadelphia chromosome
PTU
alpha 1 anti - trypsin

47. Anti - TNF antibody - use for RA but watch out for latent TB!
UMN signs
spike and dome on microscope
catalase positive coagulase negative
infliximab

48. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
HELLP syndrome
pt has extended expiratory phase
MofA Levothyroxine
TZD (glitazones) MofA

49. Membranoproliferative GN
dose response curve change with competitive antagonist
tram - track on microscope
treatment of malignant hyperthermia
lewy body composition

50. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
sarcoma botyroides
palisading nuclei - locally invasive
failure of endodermal development
chief cells