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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
plenta accreta
11 beta hydroxylase deficiency
sarcoma botyroides
cause of high pH vaginal discharge

2. Oligodendroglia
looks like fried eggs under histologic staining
lewy body composition
medial geniculate nucleus
x- linked recessive lysosomal storage diseases

3. Choriocarcinoma
Where does the spinothalamic decussate?
tumor composed of cytotrophoblasts and syncytiotrophoblasts
ovarian tumor with psammoma bodies
follicular

4. Aminocaproic acid
What causes coronary vasospasm as a SE?
t - PA - streptokinase antidote
defective tyrosine kinase
beta glucocerebrosidase

5. Radial nerve - deep brachial artery
x- linked recessive lysosomal storage diseases
blood supply for thalamus
whats the V/Q at the apex of the lung
midshaft break of humerus

6. Imabtinib
benzos antidote
LT C4 D4 E4
brenner tumor
antibody against philadelphia chromosome

7. Primary hyperaldosteronism (HTN - hypokalemia - metabolic alkalosis)

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8. ACE inhibitors
brain tumor with fried egg appearance
heXosaminidase
may lead to multiple personalities
shown to slow progression of diabetic neuropathy

9. Actinomyces
heXosaminidase
MPTP exposure causes depletion of what NT?
branching rods on oral infection
most common breast cancer

10. Hairless skin - dynamic fine touch
mildly decreased UDPGT
meissners
most common breast mass in pre - menopausal women
What artery causes locked in syndrome

11. Prazosin
intranuclear inclusions seen in herpes simplex encephalitis
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
hemangioblastomas of retina/cerebellum/medulla
pacinian

12. Achondroplasia
plenta accreta
whats the V/Q at the apex of the lung
FGFR3 mutation
alpha L iduronidase

13. Dantrolene (prevents release of calcium from SR of muscle)
absent UTPGT
treatment of malignant hyperthermia
sulfonylureas MofA
lisch nodules

14. Deficiency of aldosterone and cortisol

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15. Glucuronyl transferase
enzyme used to conjugate bilirubin
whats the V/Q at the base of the lung
sturge weber syndrome
meissners

16. Chocolate agar
neutrophils fail to respond to chemotaxic stimuli
H. flu
ventral posterior nucleus - lateral part
gram + bacteria that requires NAD and hemin for growth

17. Naloxone/naltrexone
opioids antidote
fusion inhibitors
copper - arsenic - gold antidote
plenta accreta

18. Meningioma
brain tumor with psammona bodies
microglia
most common bacteria in GI tract
strawberry tongue

19. Pemphigus vulgaris
anti - epithelial antibodies
SE: facial flushing
cause of increased myometrial excitability
hallmark sign of COPD

20. 3
chromosome 4
protease inhibitors MofA
MofA of N- aceylcysteine
whats the V/Q at the apex of the lung

21. Damaged in multiple sclerosis
most common primary cardiac tumor in kiddos
pt has extended expiratory phase
x- linked recessive lysosomal storage diseases
oligodendrioglia

22. Oligodendrogila
oligohydramnios
Lateral geniculate nucleus
cells destroyed in MS
VA/VL

23. Fibrates
VA/VL
best effect of triglycerides/VLDL
dose response curve with noncompetitive antagonist
erythema nodosum

24. Fabry's & Hunters
thyroid cancer associtated with RET oncogene
partial mole components
most common protozoal infection in US
x- linked recessive lysosomal storage diseases

25. Medullary
lisch nodules
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
cancer arising from parafollicular C cells
dose response curve with noncompetitive antagonist

26. Autosomal dominant
MofA of N- aceylcysteine
inheritance pattern for all MENs
defective tyrosine kinase
neutrophils fail to respond to chemotaxic stimuli

27. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
erythema nodosum
hemangioblastomas of retina/cerebellum/medulla
dermatin sulfate accumulation
thymidylate synthase

28. Niacins
best effect on HDL
first line for cardiogenic shock
parietal cells
oligohydramnios

29. Pneumonia - URIs - STDS
most common lysosomal storage disease
etanercept
BCG PQRS
macrolides use (PUS)

30. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
Lateral geniculate nucleus
oligohydramnios
psammoma bodies
most common first line agent for septic shock

31. Fibrates/statins
pacinian
leydig cell tumor
SE: elevated LFTS - myositis
eczema/recurrent infections/thrombocytopenia

32. Cause release of preformed insulin
sulfonylureas
cells destroyed in Guillain Barre
pseudopalisading necrosis
lisch nodules

33. Intussception
currant jelly stool
barbituates withdrawal
placenta previa
ventral posterior nucleus - lateral part

34. Basal cell carcinoma
sumatriptan
cause of low pH vaginal discharge
fusion inhibitors
palisading nuclei - locally invasive

35. Hurlers
SE: facial flushing
corneal clouding & MR
dose response curve change with competitive antagonist
schwann cells

36. Rhabdomyoma
most common primary cardiac tumor in kiddos
infliximab
corneal clouding & MR
alpha galacosidase A

37. Membranous GN
iduronidase sulfatase
failure of endodermal development
spike and dome on microscope
SE: facial flushing

38. Decreased efficacy - decreased Vmax
fusion inhibitors
oligohydramnios
3 tumors of MEN 1
dose response curve with noncompetitive antagonist

39. HTN; XY will be a girl - XX will lack secondary sex char.
alpha galacosidase A
MPTP exposure causes depletion of what NT?
glycine
17 alpha hydroxylase deficiency

40. Neurofibromatosis
SE: torsades de pointes
heparin antidote
lisch nodules
cancer arising from parafollicular C cells

41. Yolk sac tumor
Schiller Duval bodies
failure of endodermal development
VA/VL
MofA Levothyroxine

42. DiGeorge
macrolides use (PUS)
failure of endodermal development
H. flu
chief cells

43. Chronic gout. inhibits reabsorbtion of uric acid in PCT
What causes coronary vasospasm as a SE?
most common protozoal infection in US
child with partial albinism - peripherial neuropathy - recurrent infections
probenecid

44. Astrocytoma & glioblastoma multiforme
GFAP positive
FGFR3 mutation
drug that blocks purine synthesis and is metabolized by xanthine oxidase
Schiller Duval bodies

45. Sotalol - quinidine - cisapride
sphingomyelinase deficiency
currant jelly stool
SE: torsades de pointes
inheritance pattern for all MENs

46. Inhibits viral assembly
kluver bucy
MofA Levothyroxine
opioids antidote
protease inhibitors MofA

47. Macconkey's agar
Shigella
locus ceruleus
probenecid
ovarian tumor that resembles bladder epithelium

48. Rheumatic fever
11 beta hydroxylase deficiency
blocks ADP receptors to inhibit platelet aggregation
Aschoff bodies
dose response curve change with competitive antagonist

49. Normal or candida
drug that blocks purine synthesis and is metabolized by xanthine oxidase
thayer martin media
cause of low pH vaginal discharge
cough - conjunctivitis - coryza - fever

50. Cocain and sumatriptan
What causes coronary vasospasm as a SE?
VA/VL
opioid withdrawal
child with eczema - coarse facial features - cold abscesses