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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Decreased efficacy - decreased Vmax
palisading nuclei - locally invasive
lysosomal storage disease - demyelinating disease
dose response curve with noncompetitive antagonist
drug that blocks purine synthesis and is metabolized by xanthine oxidase

2. Gonorrhea
thayer martin media
precursor to GABA
schwann cells
mitral valve prolapse - liver diseae - berry aneurysm

3. Cocain and sumatriptan
strawberry tongue
meissners
What causes coronary vasospasm as a SE?
21 hydroxylase deficiency

4. Vibration - pressure
pacinian
alpha galacosidase A
What causes coronary vasospasm as a SE?
brenner tumor

5. Basilar
found in hairless skin
which nerve lifts the eyelid?
What artery causes locked in syndrome
ovarian tumor with psammoma bodies

6. Yolk sac
most common testicular tumor in infants and children up to 3 years of age
G cells
pseudopalisading necrosis
which nerve lifts the eyelid?

7. Anxiety - seizures - delirium - life threatening CV collapse
What oncogene is a/w MEN 2a/b
barbituates withdrawal
cancer arising from parafollicular C cells
cause of low pH vaginal discharge

8. Choriocarcinoma
Where does the spinothalamic decussate?
LT C4 D4 E4
may lead to multiple personalities
tumor composed of cytotrophoblasts and syncytiotrophoblasts

9. Niemann Pick
17 alpha hydroxylase deficiency
sphingomyelinase deficiency
which nerve lifts the eyelid?
colchicine

10. Memory
most common breast mass in pre - menopausal women
hippocampus
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
LT C4 D4 E4

11. ACE inhibitors
leydig cell tumor
shown to slow progression of diabetic neuropathy
keratin filled cysts
G cells

12. SICK PEG
sphingomyelinase deficiency
P450 Inhibitors
testicular tumor that can present with gynecomastia
order of nerve blockade

13. Dimercaprol
brain tumor with fried egg appearance
failure of endodermal development
What artery causes locked in syndrome
lead antidote

14. PNH
cells destroyed in Guillain Barre
silver stain of gram negative rods
hemosiderinurea + thrombosis
ventral posterior nucleus - medial part

15. Dopamine
may lead to multiple personalities
corneal clouding & MR
most common breast mass in pre - menopausal women
MPTP exposure causes depletion of what NT?

16. Combo of inhaled anesthetics & succinylcholine
contains ovarian vessels
first line for absence seizures
cause of malignant hyperthermia
Galactocerebrosidase deficiency

17. Intrinsic factor
parietal cells
looks like fried eggs under histologic staining
cells destroyed in Guillain Barre
3 tumors of MEN 1

18. Ependymoma
t - PA - streptokinase antidote
gram + bacteria that requires NAD and hemin for growth
brain tumor with perivascular pseudorosettes
first line for absence seizures

19. Kawasaki
lysosomal storage disease - demyelinating disease
vasculitis of infants and children - involving coronary arteries
LMN signs
kluver bucy

20. Gauchers
microglia
blocks ADP receptors to inhibit platelet aggregation
rate limiting step in carb digestion
crinkled paper cytoplasm

21. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
sarcoma botyroides
treatment for SIADH
whats the V/Q at the base of the lung
Bisphosphonates MofA

22. Krabbe's
t - PA - streptokinase antidote
ovarian tumor with elevate hCG
Galactocerebrosidase deficiency
ventral posterior nucleus - lateral part

23. Parathyroid - pituitary - pancreatic
dose response curve with noncompetitive antagonist
VA/VL
3 tumors of MEN 1
MofA of N- aceylcysteine

24. Thryroxine replacement
MofA Levothyroxine
meissners
what meds treat malaria
hippocampus

25. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
opioid withdrawal
granulosa cell tumor secretes what?
defective tyrosine kinase
polyhydramnios

26. S-100
oligohydramnios
melanoma tumor marker
antibody against philadelphia chromosome
drug induced lupus

27. Polyarteritis nodosa
treatment for SIADH
thyroid cancer associtated with RET oncogene
hep B seropositivity in 30% of patients
honey crusted lesions common around nose/lips

28. Oligodendroglia
oligohydramnios
may lead to multiple personalities
looks like fried eggs under histologic staining
PTU

29. Endometrial glands inside myometrium
adenomyosis
cause of low pH vaginal discharge
BCG PQRS
myelinates on PNS

30. Radial nerve - deep brachial artery
tumor composed of cytotrophoblasts and syncytiotrophoblasts
whats the V/Q at the apex of the lung
midshaft break of humerus
increased MCHC and hemolytic anemia

31. Medulloblastoma
crinkled paper cytoplasm
FGFR3 mutation
ventral posterior nucleus - medial part
homer wright rosettes

32. Glioblastoma multiforme
LT C4 D4 E4
pseudopalisading necrosis
enzyme used to conjugate bilirubin
erythema nodosum

33. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
alpha L iduronidase
SE: facial flushing
erythema nodosum
low dose ASA effects - intermediate dose - high dose

34. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
anti - epithelial antibodies
brain tumor with fried egg appearance
what meds treat malaria
sulfonylureas MofA

35. Subacute (De Quervain's) thyroiditis
What thyroid pathology has an extremely tender thyroid gland
most common breast tumor in women under 25
defective tyrosine kinase
pigmented iris hamartomas - neural tumors

36. Niacin
SE: facial flushing
GFAP positive
Where does the lateral corticospinal decussate?
barbituates withdrawal

37. A few levels above the level of entry
mildly decreased UDPGT
Abciximab
thayer martin media
Where does the spinothalamic decussate?

38. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
antibiotic with SE of eosinophilia
astrocytes
chromosome 4
rabies

39. Imabtinib
may lead to multiple personalities
I cells
antibody against philadelphia chromosome
cause of high pH vaginal discharge

40. Visceral sensory
solitarius nucleus
What hormones share a common alpha subunit
brain tumor with fried egg appearance
honey crusted lesions common around nose/lips

41. Invasive ductal
most common breast cancer
basal nucleus of Meynert
UMN signs
cells destroyed in MS

42. Autosomal dominant
inheritance pattern for all MENs
what nerve innervates the muscles of mastication?
which nerve lifts the eyelid?
child with partial albinism - peripherial neuropathy - recurrent infections

43. Ethosuximide
first line for absence seizures
tram - track on microscope
medial geniculate nucleus
antibody against philadelphia chromosome

44. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
Conn's syndrome
what cells secrete somatostatin
heparin antidote
colchicine

45. Decreased potency - increased Km
first line for absence seizures
meissners
dose response curve change with competitive antagonist
hemosiderinurea + thrombosis

46. Hereditary spherocytosis
x- linked recessive lysosomal storage diseases
antibiotic with SE of eosinophilia
increased MCHC and hemolytic anemia
hallmark sign of COPD

47. Achondroplasia
what cells secrete somatostatin
FGFR3 mutation
what inhibits prolactin secretion
locus ceruleus

48. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
may lead to multiple personalities
most common primary cardiac tumor in kiddos
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
SICK PEG

49. Cell type involved in most ovarian tumors
most common testicular tumor in infants and children up to 3 years of age
epithelial
thymidylate synthase
anti - epithelial antibodies

50. Hemangioblastoma
antibody against philadelphia chromosome
brain tumor a/w von hipple - linadu syndrome
sarcoma botyroides
copper - arsenic - gold antidote