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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Homocystienuria - Marfans
subluxation of lens
granulosa cell tumor secretes what?
meissners
grossly black liver

2. Invasive ductal
most common breast cancer
What oncogene is a/w MEN 2a/b
kluver bucy
brain tumor with perivascular pseudorosettes

3. Most common type of thyroid cancer
t - PA - streptokinase antidote
iduronidase sulfatase
P450 inducers
papillary thyroid cancer

4. Babinski - weakness - increased reflexes & tone - spastic paralysis
UMN signs
papillary thyroid cancer
looks like fried eggs under histologic staining
first line for absence seizures

5. Gauchers
lysosomal storage disease a/w renal disease
sturge weber syndrome
most common lysosomal storage disease
lisch nodules

6. Huntingtons chorea
chromosome 4
chief cells
precursor to GABA
ovarian tumor with psammoma bodies

7. Cause release of preformed insulin
myelinates on PNS
cause of LH surge
paraventricular nucleus of hypothalamus
sulfonylureas

8. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
FGFR3 mutation
hep B seropositivity in 30% of patients
tumor composed of cytotrophoblasts and syncytiotrophoblasts
LTB4

9. Fabry's
antibiotic with SE of eosinophilia
HELLP syndrome
increased MCHC and hemolytic anemia
lysosomal storage disease a/w renal disease

10. Cells of BBB
myelinates multiple CNS axons
child with partial albinism - peripherial neuropathy - recurrent infections
complete mole components
astrocytes

11. Rhabdomyoma
chief cells
Addison's
cells destroyed in Guillain Barre
most common primary cardiac tumor in kiddos

12. Gauchers
eczema/recurrent infections/thrombocytopenia
catalase positive coagulase negative
tram - track on microscope
beta glucocerebrosidase

13. SICK PEG
P450 Inhibitors
most common breast cancer
pseudopalisading necrosis
may lead to multiple personalities

14. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
colchicine
sumatriptan
What are the hormone changes seen in menopause
Abciximab

15. Dobutamine
ventral posterior nucleus - lateral part
first line for cardiogenic shock
keratin filled cysts
melanoma tumor marker

16. Gilberts
thyroid cancer associtated with RET oncogene
3 tumors of MEN 2b
mildly decreased UDPGT
G cells

17. Pemphigus vulgaris
nucleoside reverse transcriptase inhibitors
enzyme used to conjugate bilirubin
lisch nodules
anti - epithelial antibodies

18. Hunters
ventral posterior nucleus - medial part
placenta previa
iduronidase sulfatase
what nerve innervates the muscles of mastication?

19. Staph epidermidis - staph sapro
catalase positive coagulase negative
crinkled paper cytoplasm
Conn's syndrome
D cells

20. NE
ovarian tumor that resembles bladder epithelium
what checkpoint is p53 involved with?
crinkled paper cytoplasm
most common first line agent for septic shock

21. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
what nerve innervates the muscles of mastication?
MofA of N- aceylcysteine
drug induced lupus
MofA Levothyroxine

22. Imabtinib
cause of low pH vaginal discharge
von Hippel Lindau disease
antibody against philadelphia chromosome
GABA - glutamine

23. Clopidogrel - ticoplidine
blocks ADP receptors to inhibit platelet aggregation
preeclampsia
paraventricular nucleus of hypothalamus
defective tyrosine kinase

24. Obstructive - COPD
LMN signs
P450 Inhibitors
MofA of N- aceylcysteine
pt has extended expiratory phase

25. HTN - proteinuria - edema
epithelial
preeclampsia
opioids antidote
alpha 1 anti - trypsin

26. PNH
von Hippel Lindau disease
ovarian tumor with psammoma bodies
hemosiderinurea + thrombosis
partial mole components

27. Krabbe's
Galactocerebrosidase deficiency
barbituates withdrawal
contains ovarian vessels
macrolides use (PUS)

28. Atrial fibrillation
etanercept
rate limiting step in carb digestion
enzyme used to conjugate bilirubin
most common arrthymia

29. Causes vasoconstriction (use for acute migraines)
precursor to GABA
anti - mitochondrial antibodies
hemosiderinurea and thrombosis
sumatriptan

30. Radial nerve - deep brachial artery
midshaft break of humerus
oligohydramnios
ambiguous nucleus
sarcoma botyroides

31. Panacinar
iduronidase sulfatase
brain tumor with psammona bodies
alpha 1 anti - trypsin
Lewy bodies composition

32. Seborric keratosis
keratin filled cysts
grossly black liver
cause of increased myometrial excitability
what meds treat malaria

33. Second most common type of thyroid cancer
follicular
brenner tumor
brain tumor a/w von hipple - linadu syndrome
Where does the lateral corticospinal decussate?

34. BCG PQRS
drug induced lupus
P450 inducers
best effect of triglycerides/VLDL
colchicine

35. Increases platelet aggregation and vasoconstriction
low dose ASA effects - intermediate dose - high dose
erythema nodosum
sulfonylureas
thromboxane A2

36. DiGeorge
Conn's syndrome
failure of endodermal development
ependymal cells
11 beta hydroxylase deficiency

37. Oligodendoglia
brain tumor with perivascular pseudorosettes
enzyme used to conjugate bilirubin
myelinates multiple CNS axons
adenomyosis

38. Ach
locus ceruleus
t - PA - streptokinase antidote
basal nucleus of Meynert
most common breast cancer

39. Hurlers
ventral posterior nucleus - lateral part
corneal clouding & MR
Conn's syndrome
palisading nuclei - locally invasive

40. Ovarian bengin tumor...looks like bladder
benzos antidote
thymidylate synthase
brenner tumor
macrolides use (PUS)

41. 3
brenner tumor
absent UTPGT
whats the V/Q at the apex of the lung
blood supply for thalamus

42. Meissner
honey crusted lesions common around nose/lips
etanercept
found in hairless skin
medial geniculate nucleus

43. Damaged in multiple sclerosis
infliximab
polyhydramnios
pseudopalisading necrosis
oligodendrioglia

44. Gauchers
crinkled paper cytoplasm
hep B seropositivity in 30% of patients
What artery causes locked in syndrome
thromboxane A2

45. Estrogen
blocks ADP receptors to inhibit platelet aggregation
cause of LH surge
what checkpoint is p53 involved with?
What oncogene is a/w MEN 2a/b

46. Yolk sac
brain tumor with perivascular pseudorosettes
most common testicular tumor in infants and children up to 3 years of age
optically clear nuclei (orphan annie)
cells destroyed in Guillain Barre

47. Chediak - Higashi
child with partial albinism - peripherial neuropathy - recurrent infections
sulfonylureas side effect
dermatin sulfate accumulation
strawberry tongue

48. Polyarteritis nodosa
vasculitis a/w Hep B
raphe nucleus
P450 Inhibitors
ventral posterior nucleus - medial part

49. Visual (Lateral for Light)
Lateral geniculate nucleus
17 alpha hydroxylase deficiency
GM2 ganglioside accumulation
hemosiderinurea and thrombosis

50. Fibrates
supraoptic nucleus of hypothalamus
Abciximab
nucleoside reverse transcriptase inhibitors
best effect of triglycerides/VLDL