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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Gauchers
SE: facial flushing
beta glucocerebrosidase
catalase positive coagulase negative
GM2 ganglioside accumulation

2. Papillary CA of thyroid
What are the hormone changes seen in menopause
PGI2 (prostacyclin))
vasculitis of infants and children - involving coronary arteries
optically clear nuclei (orphan annie)

3. NE
spike and dome on microscope
most common first line agent for septic shock
sturge weber syndrome
vasculitis of infants and children - involving coronary arteries

4. Superchiasmic nucleus
first line for absence seizures
master clock for circadian rhythms
Conn's syndrome
form multinucleated giant cells in the CNS when infected with HIV

5. Masculinization - hypovolemic shock
first line for absence seizures
21 hydroxylase deficiency
may lead to multiple personalities
thayer martin media

6. Causes vasoconstriction (use for acute migraines)
brenner tumor
sumatriptan
first line for absence seizures
LMN signs

7. Polyarteritis nodosa
most common breast cancer
cause of malignant hyperthermia
what inhibits prolactin secretion
hep B seropositivity in 30% of patients

8. Alpha feto protein
hemosiderinurea + thrombosis
Yolk sac tumor produces...
whats the V/Q at the apex of the lung
PTU

9. A/w esophageal/duodenal atresia and anencephaly
polyhydramnios
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
P450 Inhibitors
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

10. Alpha synuclein
myelinates on PNS
copper - arsenic - gold antidote
lewy body composition
neutrophils fail to respond to chemotaxic stimuli

11. 2 sperm + 1 egg (fetal parts present)
catalase negative
GM2 ganglioside accumulation
midshaft break of humerus
partial mole components

12. Inhibitory in the SC
5 alpha reductase deficiency
oligodendrioglia
glycine
ovarian tumor with psammoma bodies

13. Schwann cells
thayer martin media
myelinates on PNS
what cells secrete somatostatin
keratin filled cysts

14. Anti - TNF antibody - use for RA but watch out for latent TB!
macrolides use (PUS)
infliximab
order of nerve blockade
hydatidiform mole with crazy high hCG

15. Cowdry type A inclusions
SE: facial flushing
intranuclear inclusions seen in herpes simplex encephalitis
catalase negative
whats the V/Q at the apex of the lung

16. Actinomyces
what cells secrete somatostatin
hemosiderinurea and thrombosis
most common first line agent for septic shock
branching rods on oral infection

17. Clopidogrel - ticoplidine
colchicine
blocks ADP receptors to inhibit platelet aggregation
anti - epithelial antibodies
cough - conjunctivitis - coryza - fever

18. Protamine sulfate
basal nucleus of Meynert
GM2 ganglioside accumulation
ambiguous nucleus
heparin antidote

19. Actinomyces
pt has extended expiratory phase
branching rods on oral infection
heXosaminidase
complete mole components

20. SICK PEG
pseudopalisading necrosis
P450 Inhibitors
most common lysosomal storage disease
glycine

21. Fabry's
lysosomal storage disease a/w renal disease
grossly black liver
what cells secrete somatostatin
x- linked recessive lysosomal storage diseases

22. NE
SE: facial flushing
locus ceruleus
lewy body composition
SE: elevated LFTS - myositis

23. Trichomonas - Giardia
iduronidase sulfatase
whats the V/Q at the apex of the lung
most common protozoal infection in US
catalase negative

24. Oculomotor
most common breast mass in pre - menopausal women
21 hydroxylase deficiency
Addison's
which nerve lifts the eyelid?

25. Chocolate agar
master clock for circadian rhythms
first line for cardiogenic shock
H. flu
solitarius nucleus

26. Wiscott - Aldrich
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
eczema/recurrent infections/thrombocytopenia
21 hydroxylase deficiency
defective tyrosine kinase

27. Membranous GN
kawasaki
spike and dome on microscope
contains ovarian vessels
Where does the lateral corticospinal decussate?

28. Memory
glycine
oligodendrioglia
Addison's
hippocampus

29. Fabry's & Hunters
catalase negative
x- linked recessive lysosomal storage diseases
first line for cardiogenic shock
cells destroyed in MS

30. Dubin Johnson
grossly black liver
ovarian tumor that resembles bladder epithelium
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
most common first line agent for septic shock

31. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
kawasaki
sclerosing adenosis
brain tumor with psammona bodies
corneal clouding & MR

32. HTN; XY will be a girl - XX will lack secondary sex char.
17 alpha hydroxylase deficiency
lysosomal storage disease - demyelinating disease
cells destroyed in MS
contains ovarian vessels

33. Invasive ductal
plenta accreta
child with partial albinism - peripherial neuropathy - recurrent infections
most common breast cancer
pacinian

34. Invasive ductal CA
3 tumors of MEN 1
spike and dome on microscope
may lead to multiple personalities
most common breast mass in postmenopausal women

35. Weakness - atrophy - fasiculations - decreased reflexes & tone
most common arrthymia
LMN signs
what checkpoint is p53 involved with?
3 tumors of MEN 2a

36. Inhibits viral assembly
protease inhibitors MofA
drug induced lupus
benzos antidote
What artery causes locked in syndrome

37. Primary hyperaldosteronism (HTN - hypokalemia - metabolic alkalosis)

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38. Pneumonia - URIs - STDS
macrolides use (PUS)
hep B seropositivity in 30% of patients
BCG PQRS
Addison's

39. Flumazenil
enzyme used to conjugate bilirubin
sulfonylureas MofA
subluxation of lens
benzos antidote

40. Atrial fibrillation
treatment of malignant hyperthermia
treatment for SIADH
most common gyno malignancy
most common arrthymia

41. Babinski - weakness - increased reflexes & tone - spastic paralysis
lysosomal storage disease - demyelinating disease
UMN signs
alpha L iduronidase
alpha galacosidase A

42. Dopamine
GM2 ganglioside accumulation
MPTP exposure causes depletion of what NT?
lisch nodules
thyroid cancer associtated with RET oncogene

43. Intrinsic factor
myelinates multiple CNS axons
infliximab
cells destroyed in MS
parietal cells

44. Inhibits osteoclastic activity
dose response curve change with competitive antagonist
H. flu
Bisphosphonates MofA
thymidylate synthase

45. Bromocriptine
meissners
x- linked recessive lysosomal storage diseases
metformin side effect
what inhibits prolactin secretion

46. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
most common protozoal infection in US
vasculitis a/w Hep B
17 alpha hydroxylase deficiency
drug induced lupus

47. Ependymoma
most common arrthymia
brain tumor with perivascular pseudorosettes
benzos antidote
tumor with call - exner bodies

48. Subacute (De Quervain's) thyroiditis
alpha galacosidase A
found in hairless skin
What thyroid pathology has an extremely tender thyroid gland
cancer associated with Hashimoto's thyroiditis

49. B. fragilis
most common arrthymia
most common bacteria in GI tract
infliximab
meissners

50. PNH
child with partial albinism - peripherial neuropathy - recurrent infections
hemosiderinurea and thrombosis
what meds treat malaria
FGFR3 mutation