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USMLE Pathophys

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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1. Damaged in multiple sclerosis
opioid withdrawal
currant jelly stool
oligodendrioglia
tram - track on microscope

2. Actinomyces
G cells
LMN signs
branching rods on oral infection
catalase positive coagulase negative

3. Niacins
shown to slow progression of diabetic neuropathy
tram - track on microscope
best effect on HDL
first line for absence seizures

4. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
5 alpha reductase deficiency
Shigella
nucleoside reverse transcriptase inhibitors
erythema nodosum

5. Decreased efficacy - decreased Vmax
dose response curve with noncompetitive antagonist
diphtheria treatment
P450 Inhibitors
whats the V/Q at the base of the lung

6. Babinski - weakness - increased reflexes & tone - spastic paralysis
master clock for circadian rhythms
21 hydroxylase deficiency
anti - mitochondrial antibodies
UMN signs

7. Intrinsic factor
parietal cells
currant jelly stool
inheritance pattern for all MENs
what meds treat malaria

8. Hurlers
Schiller Duval bodies
corneal clouding & MR
resembles an onion in cross section
sulfonylureas

9. Fibrates
best effect of triglycerides/VLDL
alpha L iduronidase
x- linked recessive lysosomal storage diseases
most common arrthymia

10. Astrocytoma & glioblastoma multiforme
cause of malignant hyperthermia
brain tumor with fried egg appearance
GFAP positive
What hormones share a common alpha subunit

11. Oligodendroglia
whats the V/Q at the apex of the lung
P450 inducers
looks like fried eggs under histologic staining
sarcoma botyroides

12. Tay Sachs
defective tyrosine kinase
eczema/recurrent infections/thrombocytopenia
GM2 ganglioside accumulation
optically clear nuclei (orphan annie)

13. Serous cystadenocarcinoma
ovarian tumor with psammoma bodies
anti - platelet antibodies
master clock for circadian rhythms
sphingomyelinase deficiency

14. Parathyroid - pituitary - pancreatic
sulfonylureas
intranuclear inclusions seen in herpes simplex encephalitis
3 tumors of MEN 1
benzos antidote

15. Cant convert testosterone to DHT - ambiguous genitalia until puberty then penis at 12
5 alpha reductase deficiency
brain tumor a/w von hipple - linadu syndrome
drug that blocks purine synthesis and is metabolized by xanthine oxidase
brain tumor with fried egg appearance

16. Motor
most common breast mass in pre - menopausal women
VA/VL
locus ceruleus
placenta previa

17. Fabry's
Aschoff bodies
lysosomal storage disease a/w renal disease
3 tumors of MEN 2b
cause of high pH vaginal discharge

18. Glioblastoma multiforme
brain tumor with perivascular pseudorosettes
pseudopalisading necrosis
Galactocerebrosidase deficiency
hippocampus

19. Ovarian bengin tumor...looks like bladder
brenner tumor
probenecid
opioids antidote
most common breast mass in pre - menopausal women

20. 6- MP
MofA Levothyroxine
21 hydroxylase deficiency
drug that blocks purine synthesis and is metabolized by xanthine oxidase
what inhibits prolactin secretion

21. 5- fluorouracil
anti - mitochondrial antibodies
thymidylate synthase
Shigella
intranuclear inclusions seen in herpes simplex encephalitis

22. Medulla
neutrophils fail to respond to chemotaxic stimuli
Where does the dorsal column decussate?
BCG PQRS
cancer arising from parafollicular C cells

23. Granulosa cell tumor
preeclampsia
What causes coronary vasospasm as a SE?
thyroid cancer associtated with RET oncogene
tumor with call - exner bodies

24. Gonorrhea
raphe nucleus
thayer martin media
optically clear nuclei (orphan annie)
propylthiouracil side effects

25. Body sensation
brain tumor with fried egg appearance
hep B seropositivity in 30% of patients
probenecid
ventral posterior nucleus - lateral part

26. Choriocarcinoma
tumor composed of cytotrophoblasts and syncytiotrophoblasts
t - PA - streptokinase antidote
may lead to multiple personalities
ovarian tumor that resembles bladder epithelium

27. Pemphigus vulgaris
vasculitis of infants and children - involving coronary arteries
anti - epithelial antibodies
abruptio placentae
cough - conjunctivitis - coryza - fever

28. Deficiency of aldosterone and cortisol

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29. HTN - proteinuria - edema
precursor to GABA
sumatriptan
preeclampsia
looks like fried eggs under histologic staining

30. Microglia
whats the V/Q at the base of the lung
Aschoff bodies
strawberry tongue
form multinucleated giant cells in the CNS when infected with HIV

31. G1/S & G2/M
what checkpoint is p53 involved with?
myelinates multiple CNS axons
placenta previa
P450 inducers

32. Krabbe's
Galactocerebrosidase deficiency
dorsal motor nucleus
barbituates withdrawal
cause of LH surge

33. Amygdala
hemangioblastomas of retina/cerebellum/medulla
intranuclear inclusions seen in herpes simplex encephalitis
most common testicular tumor in infants and children up to 3 years of age
kluver bucy

34. Negri bodies
what cells secrete somatostatin
rabies
low dose ASA effects - intermediate dose - high dose
Conn's syndrome

35. Intussception
locus ceruleus
currant jelly stool
whats the V/Q at the apex of the lung
Abciximab

36. Polyarteritis nodosa
hep B seropositivity in 30% of patients
dose response curve change with competitive antagonist
polyhydramnios
gram + bacteria that requires NAD and hemin for growth

37. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
MPTP exposure causes depletion of what NT?
low dose ASA effects - intermediate dose - high dose
x- linked recessive lysosomal storage diseases
parietal cells

38. 2 sperm + empty egg (no fetal parts)
complete mole components
t - PA - streptokinase antidote
ventral posterior nucleus - medial part
melanoma tumor marker

39. Suspensory ligament of ovaries
most common testicular tumor in infants and children up to 3 years of age
brain tumor a/w von hipple - linadu syndrome
contains ovarian vessels
leydig cell tumor

40. Naloxone/naltrexone
grossly black liver
copper - arsenic - gold antidote
kluver bucy
opioids antidote

41. Glutamate
strawberry tongue
metformin side effect
pseudopalisading necrosis
precursor to GABA

42. Demeclycocycline or water restriction
lewy body composition
treatment for SIADH
honey crusted lesions common around nose/lips
first line for absence seizures

43. Oligodendoglia
myelinates multiple CNS axons
Conn's syndrome
sulfonylureas
pacinian

44. Alpha synuclein
pt has extended expiratory phase
Lewy bodies composition
heXosaminidase
papillary thyroid cancer

45. Dantrolene (prevents release of calcium from SR of muscle)
UMN signs
treatment of malignant hyperthermia
MofA Levothyroxine
granulosa cell tumor secretes what?

46. Membranous GN
spike and dome on microscope
BCG PQRS
most common breast mass in pre - menopausal women
parietal cells

47. Second most common type of thyroid cancer
raphe nucleus
homer wright rosettes
intranuclear inclusions seen in herpes simplex encephalitis
follicular

48. Hurlers
TZD (glitazones) MofA
most common testicular tumor in infants and children up to 3 years of age
alpha L iduronidase
anti - mitochondrial antibodies

49. Causes vasoconstriction (use for acute migraines)
BCG PQRS
sumatriptan
subluxation of lens
schwann cells

50. Medulla
Where does the lateral corticospinal decussate?
fusion inhibitors
Lewy bodies composition
barbituates withdrawal

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USMLE Pathophys

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