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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Panacinar
alpha 1 anti - trypsin
ependymal cells
alpha galacosidase A
pseudopalisading necrosis

2. Medulloblastoma
kawasaki
ventral posterior nucleus - lateral part
homer wright rosettes
granulosa cell tumor secretes what?

3. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
Where does the lateral corticospinal decussate?
FGFR3 mutation
LT C4 D4 E4
dose response curve change with competitive antagonist

4. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
sulfonylureas side effect
papillary thyroid cancer
mildly decreased UDPGT
sulfonylureas MofA

5. Imabtinib
antibody against philadelphia chromosome
ovarian tumor with psammoma bodies
dermatin sulfate accumulation
GABA - glutamine

6. Sends autonomic fibers to heart
What thyroid pathology has an extremely tender thyroid gland
dorsal motor nucleus
partial mole components
absent UTPGT

7. Ovarian bengin tumor...looks like bladder
brenner tumor
what inhibits prolactin secretion
Addison's
What hormones share a common alpha subunit

8. Astrocytoma & glioblastoma multiforme
spike and dome on microscope
GFAP positive
astrocytes
rate limiting step in carb digestion

9. Macconkey's agar
Shigella
vasculitis of infants and children - involving coronary arteries
most common breast tumor in women under 25
defective tyrosine kinase

10. 6- mecaptopurine (metabolized by xanthine oxidase)
which nerve lifts the eyelid?
enzyme used to conjugate bilirubin
What causes coronary vasospasm as a SE?
bocks PRPP synthetase to block purine synthesis

11. Macrophages of the CNS
Lateral geniculate nucleus
microglia
ventral posterior nucleus - lateral part
deficiency of mannose phosphorylation

12. Dopamine
3 tumors of MEN 2b
von Hippel Lindau disease
MPTP exposure causes depletion of what NT?
order of nerve blockade

13. Intussception
currant jelly stool
testicular tumor that can present with gynecomastia
cough - conjunctivitis - coryza - fever
etanercept

14. A few levels above the level of entry
Where does the spinothalamic decussate?
defective tyrosine kinase
pseudopalisading necrosis
3 tumors of MEN 1

15. Flumazenil
optically clear nuclei (orphan annie)
lisch nodules
benzos antidote
pseudopalisading necrosis

16. Obstructive - COPD
lewy body composition
pt has extended expiratory phase
cancer associated with Hashimoto's thyroiditis
found in hairless skin

17. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
lead antidote
low dose ASA effects - intermediate dose - high dose
SICK PEG
branching rods on oral infection

18. Yolk sac
most common testicular tumor in infants and children up to 3 years of age
drug that blocks purine synthesis and is metabolized by xanthine oxidase
ambiguous nucleus
keratin filled cysts

19. Estrogen
fusion inhibitors
cause of increased myometrial excitability
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
optically clear nuclei (orphan annie)

20. Radial nerve - deep brachial artery
crinkled paper cytoplasm
midshaft break of humerus
rate limiting step in carb digestion
Aschoff bodies

21. Estrogen (causes precocious puberty)
granulosa cell tumor secretes what?
GFAP positive
astrocytes
HELLP syndrome

22. Small diameter > large diameter; myelinated > unmyelinated
order of nerve blockade
VA/VL
sulfonylureas side effect
alpha 1 anti - trypsin

23. Legionella
von Hippel Lindau disease
silver stain of gram negative rods
barbituates withdrawal
intranuclear inclusions seen in herpes simplex encephalitis

24. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
astrocytes
SE: elevated LFTS - myositis
lysosomal storage disease - demyelinating disease
dose response curve change with competitive antagonist

25. Rheumatic fever
Aschoff bodies
chief cells
absent UTPGT
mildly decreased UDPGT

26. Invasive ductal
most common breast cancer
epithelial
alpha L iduronidase
Where does the lateral corticospinal decussate?

27. Visual (Lateral for Light)
brenner tumor
metformin side effect
Lateral geniculate nucleus
I cells

28. Antibody binds to gp2b/3a - preventing aggregation
thromboxane A2
Abciximab
first line for absence seizures
P450 Inhibitors

29. Chediak - Higashi
sphingomyelinase deficiency
partial mole components
Galactocerebrosidase deficiency
child with partial albinism - peripherial neuropathy - recurrent infections

30. PNH
master clock for circadian rhythms
3 tumors of MEN 2a
hemosiderinurea + thrombosis
brain tumor a/w von hipple - linadu syndrome

31. 2 sperm + 1 egg (fetal parts present)
partial mole components
complete mole components
cancer associated with Hashimoto's thyroiditis
granulosa cell tumor secretes what?

32. Weakness - atrophy - fasiculations - decreased reflexes & tone
lewy body composition
LMN signs
silver stain of gram negative rods
catalase positive coagulase negative

33. Negri bodies
rabies
master clock for circadian rhythms
von Hippel Lindau disease
what checkpoint is p53 involved with?

34. Parathyroid - pituitary - pancreatic
benzos antidote
hemosiderinurea and thrombosis
3 tumors of MEN 1
first line for absence seizures

35. Homocystienuria - Marfans
abruptio placentae
ovarian tumor with psammoma bodies
brain tumor with foamy cells and high vascularity
subluxation of lens

36. Aminocaproic acid
TZD (glitazones) MofA
t - PA - streptokinase antidote
copper - arsenic - gold antidote
basal nucleus of Meynert

37. Placenta attached to myometrium
lysosomal storage disease - demyelinating disease
solitarius nucleus
plenta accreta
cause of high pH vaginal discharge

38. Hurlers - Hunters
most common lysosomal storage disease
locus ceruleus
SE: facial flushing
dermatin sulfate accumulation

39. Membranous GN
spike and dome on microscope
form multinucleated giant cells in the CNS when infected with HIV
order of nerve blockade
etanercept

40. Hypoglycemia
chief cells
alpha 1 anti - trypsin
sulfonylureas side effect
opioid withdrawal

41. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
3 tumors of MEN 2b
best effect of triglycerides/VLDL
hallmark sign of COPD
ambiguous nucleus

42. 3
what cells secrete somatostatin
astrocytes
precursor to GABA
whats the V/Q at the apex of the lung

43. Cocain and sumatriptan
solitarius nucleus
sturge weber syndrome
What causes coronary vasospasm as a SE?
which nerve lifts the eyelid?

44. Macrolides
H. flu
abruptio placentae
cells destroyed in Guillain Barre
antibiotic with SE of eosinophilia

45. Schwann cells
precursor to GABA
sclerosing adenosis
catalase negative
cells destroyed in Guillain Barre

46. 6- MP
Lateral geniculate nucleus
PTU
drug that blocks purine synthesis and is metabolized by xanthine oxidase
Lewy bodies composition

47. Hemangioblastoma
ventral posterior nucleus - lateral part
beta glucocerebrosidase
Abciximab
brain tumor a/w von hipple - linadu syndrome

48. Increases platelet aggregation and vasoconstriction
D cells
thromboxane A2
treatment for SIADH
schwann cells

49. Oligodendrioma
brain tumor with fried egg appearance
best effect on HDL
iduronidase sulfatase
what checkpoint is p53 involved with?

50. Primary biliary cirrhosis
smoking emphysema
diphtheria treatment
What thyroid pathology has an extremely tender thyroid gland
anti - mitochondrial antibodies