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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. TNF receptor
mitral valve prolapse - liver diseae - berry aneurysm
Lateral geniculate nucleus
GABA - glutamine
etanercept

2. Hurlers
alpha L iduronidase
placenta previa
MPTP exposure causes depletion of what NT?
medial geniculate nucleus

3. Auditory (Medial for Music)
granulosa cell tumor secretes what?
medial geniculate nucleus
strawberry tongue
Lewy bodies composition

4. Aplastic anemia - rash - agranulocytosis
SE: facial flushing
P450 Inhibitors
propylthiouracil side effects
solitarius nucleus

5. Niacins
best effect on HDL
Conn's syndrome
cells destroyed in Guillain Barre
lysosomal storage disease a/w renal disease

6. Glucuronyl transferase
enzyme used to conjugate bilirubin
What causes coronary vasospasm as a SE?
kluver bucy
hemosiderinurea + thrombosis

7. Polyarteritis nodosa
probenecid
polyhydramnios
GM2 ganglioside accumulation
vasculitis a/w Hep B

8. Gauchers
crinkled paper cytoplasm
child with eczema - coarse facial features - cold abscesses
bocks PRPP synthetase to block purine synthesis
alpha 1 anti - trypsin

9. Inhibits osteoclastic activity
lead antidote
Bisphosphonates MofA
pigmented iris hamartomas - neural tumors
found in hairless skin

10. Anti - TNF antibody - use for RA but watch out for latent TB!
smoking emphysema
infliximab
what nerve innervates the muscles of mastication?
corneal clouding & MR

11. Chediak - Higashi
MPTP exposure causes depletion of what NT?
lewy body composition
child with partial albinism - peripherial neuropathy - recurrent infections
locus ceruleus

12. Schwann cells
ependymal cells
parietal cells
myelinates on PNS
myelinates multiple CNS axons

13. S-100
melanoma tumor marker
whats the V/Q at the base of the lung
may lead to multiple personalities
LT C4 D4 E4

14. Invasive ductal
macrolides use (PUS)
3 tumors of MEN 1
most common breast cancer
oligodendrioglia

15. Port wine stains - ipsilateral leptomeningeal angioma; can cause glaucoma - seizures - hemipareis - and MR
brain tumor with psammona bodies
sturge weber syndrome
ovarian tumor with psammoma bodies
raphe nucleus

16. Ethosuximide
first line for absence seizures
myelinates multiple CNS axons
locus ceruleus
Schiller Duval bodies

17. Ovarian bengin tumor...looks like bladder
brenner tumor
MPTP exposure causes depletion of what NT?
P450 Inhibitors
sulfonylureas side effect

18. Niemann Pick
sphingomyelinase deficiency
placenta previa
sumatriptan
pacinian

19. Astrocytoma & glioblastoma multiforme
most common breast cancer
branching rods on oral infection
GFAP positive
ovarian tumor that resembles bladder epithelium

20. 2 sperm + empty egg (no fetal parts)
complete mole components
medial geniculate nucleus
etanercept
kluver bucy

21. Decreases conversion
What oncogene is a/w MEN 2a/b
HELLP syndrome
cause of low pH vaginal discharge
PTU

22. Ependymoma
most common primary cardiac tumor in kiddos
P450 Inhibitors
brain tumor with perivascular pseudorosettes
3 tumors of MEN 1

23. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
SE: facial flushing
PGI2 (prostacyclin))
macrolides use (PUS)
kawasaki

24. Seminoma
testicular tumor that can present with gynecomastia
hemosiderinurea and thrombosis
most common testicular tumor
diphtheria treatment

25. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
treatment of malignant hyperthermia
sturge weber syndrome
colchicine
preeclampsia

26. Dissociative
may lead to multiple personalities
cancer arising from parafollicular C cells
basal nucleus of Meynert
UMN signs

27. Rheumatic fever
grossly black liver
dermatin sulfate accumulation
Aschoff bodies
chromosome 4

28. Benign - contains Reinke crystals - usually androgen producing
S cells
leydig cell tumor
P450 inducers
found in hairless skin

29. A/w esophageal/duodenal atresia and anencephaly
barbituates withdrawal
polyhydramnios
sulfonylureas
cells destroyed in Guillain Barre

30. Body sensation
ventral posterior nucleus - lateral part
most common gyno malignancy
3 tumors of MEN 2a
paraventricular nucleus of hypothalamus

31. Hurlers
most common breast mass in postmenopausal women
corneal clouding & MR
lewy body composition
nucleoside reverse transcriptase inhibitors

32. Papillary CA of thyroid
Where does the spinothalamic decussate?
best effect on HDL
optically clear nuclei (orphan annie)
astrocytes

33. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
most common primary cardiac tumor in kiddos
hep B seropositivity in 30% of patients
brain tumor with fried egg appearance
sulfonylureas MofA

34. Negri bodies
rabies
locus ceruleus
basal nucleus of Meynert
supraoptic nucleus of hypothalamus

35. G1/S & G2/M
papillary thyroid cancer
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
what checkpoint is p53 involved with?
heXosaminidase

36. Antibody binds to gp2b/3a - preventing aggregation
Abciximab
papillary thyroid cancer
P450 Inhibitors
preeclampsia

37. Decreased efficacy - decreased Vmax
von Hippel Lindau disease
I cells
metformin side effect
dose response curve with noncompetitive antagonist

38. Trigeminal
cause of low pH vaginal discharge
raphe nucleus
what nerve innervates the muscles of mastication?
brenner tumor

39. Schwann cells
smoking emphysema
cells destroyed in Guillain Barre
mitral valve prolapse - liver diseae - berry aneurysm
PTU

40. Fibroadenoma
G cells
grossly black liver
most common breast tumor in women under 25
hydatidiform mole with crazy high hCG

41. Bruton's agammaglobulinemia
pigmented iris hamartomas - neural tumors
microglia
most common breast cancer
defective tyrosine kinase

42. Radial nerve - deep brachial artery
shown to slow progression of diabetic neuropathy
midshaft break of humerus
heXosaminidase
silver stain of gram negative rods

43. Hemolysis - elevated LFTs - Low Platelets
chromosome 4
iduronidase sulfatase
most common breast mass in pre - menopausal women
HELLP syndrome

44. Makes ADH
rabies
supraoptic nucleus of hypothalamus
S cells
H. flu

45. HTN; masculinization
adenomyosis
11 beta hydroxylase deficiency
BCG PQRS
raphe nucleus

46. Medulla
whats the V/Q at the apex of the lung
Where does the lateral corticospinal decussate?
MPTP exposure causes depletion of what NT?
MofA Levothyroxine

47. SICK PEG
microglia
first line for absence seizures
P450 Inhibitors
currant jelly stool

48. Medullary thyroid - pheochromocytoma - parathryoid
hallmark sign of COPD
3 tumors of MEN 2a
most common testicular tumor
cause of LH surge

49. Imabtinib
cells destroyed in Guillain Barre
antibody against philadelphia chromosome
what inhibits prolactin secretion
cause of malignant hyperthermia

50. Cavernous hemangiomas in skin - mucosa & organs; autosomal dominant - a/w renal CA - hemangioblastoma in retina - brainstem & cerebellum
von Hippel Lindau disease
21 hydroxylase deficiency
hemangioblastomas of retina/cerebellum/medulla
Lateral geniculate nucleus