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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Endometrial glands inside myometrium
PGI2 (prostacyclin))
master clock for circadian rhythms
adenomyosis
ovarian tumor with elevate hCG

2. Motor innervation of pharynx - larynx and upper esophagus
ambiguous nucleus
medial geniculate nucleus
What causes coronary vasospasm as a SE?
intranuclear inclusions seen in herpes simplex encephalitis

3. Homocystienuria - Marfans
dorsal motor nucleus
subluxation of lens
cause of LH surge
grossly black liver

4. Fabry's & Hunters
first line for cardiogenic shock
x- linked recessive lysosomal storage diseases
cause of increased myometrial excitability
SE: elevated LFTS - myositis

5. Premature detachment of placenta - painful bleeding in 3rd trimester
abruptio placentae
polyhydramnios
meissners
sturge weber syndrome

6. Decreased follicles & estrogen with increased FSH & LH
brenner tumor
What are the hormone changes seen in menopause
P450 inducers
dorsal motor nucleus

7. Estrogen
SE: torsades de pointes
anti - mitochondrial antibodies
nucleoside reverse transcriptase inhibitors
cause of LH surge

8. Subacute (De Quervain's) thyroiditis
Schiller Duval bodies
What thyroid pathology has an extremely tender thyroid gland
myelinates multiple CNS axons
H. flu

9. Vibration - pressure
pacinian
strawberry tongue
TZD (glitazones) MofA
hep B seropositivity in 30% of patients

10. Trichomonas or bacterial vaginosis
tram - track on microscope
cause of high pH vaginal discharge
hydatidiform mole with crazy high hCG
Abciximab

11. ITP
tram - track on microscope
most common breast mass in postmenopausal women
cancer associated with Hashimoto's thyroiditis
anti - platelet antibodies

12. Oligodendroglia
von Hippel Lindau disease
looks like fried eggs under histologic staining
locus ceruleus
What oncogene is a/w MEN 2a/b

13. Actinomyces
most common breast mass in pre - menopausal women
branching rods on oral infection
ovarian tumor with psammoma bodies
most common protozoal infection in US

14. Kawasaki (treat with high dose aspirin)
strawberry tongue
honey crusted lesions common around nose/lips
currant jelly stool
diphtheria treatment

15. 2 sperm + empty egg (no fetal parts)
complete mole components
alpha 1 anti - trypsin
most common testicular tumor in infants and children up to 3 years of age
myelinates multiple CNS axons

16. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
SE: torsades de pointes
strawberry tongue
GABA - glutamine
TZD (glitazones) MofA

17. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
PGI2 (prostacyclin))
lead antidote
melanoma tumor marker
brain tumor with perivascular pseudorosettes

18. Aminocaproic acid
t - PA - streptokinase antidote
brenner tumor
iduronidase sulfatase
corneal clouding & MR

19. Intrinsic factor
smoking emphysema
parietal cells
leydig cell tumor
hydrocele

20. Deficiency of aldosterone and cortisol

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21. Membranous GN
glycine
spike and dome on microscope
macrolides use (PUS)
3 tumors of MEN 2a

22. Body sensation
plenta accreta
rate limiting step in carb digestion
ventral posterior nucleus - lateral part
microglia

23. Damaged in Guillian Barre
schwann cells
strawberry tongue
may lead to multiple personalities
copper - arsenic - gold antidote

24. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
propylthiouracil side effects
psammoma bodies
catalase negative
most common protozoal infection in US

25. Rheumatic fever
Aschoff bodies
S cells
best effect on HDL
dose response curve change with competitive antagonist

26. NE
What hormones share a common alpha subunit
dose response curve with noncompetitive antagonist
MofA Levothyroxine
locus ceruleus

27. Pemphigus vulgaris
VA/VL
anti - epithelial antibodies
most common first line agent for septic shock
found in hairless skin

28. Inhibitory in the SC
opioids antidote
cancer associated with Hashimoto's thyroiditis
leydig cell tumor
glycine

29. Serous cystadenocarcinoma
ovarian tumor with psammoma bodies
Where does the spinothalamic decussate?
locus ceruleus
PGI2 (prostacyclin))

30. Brenners tumor
hydatidiform mole with crazy high hCG
ovarian tumor that resembles bladder epithelium
locus ceruleus
child with eczema - coarse facial features - cold abscesses

31. Ret
lisch nodules
epithelial
GFAP positive
What oncogene is a/w MEN 2a/b

32. Fibroadenoma
most common breast tumor in women under 25
cause of LH surge
glycine
SE: elevated LFTS - myositis

33. Gastrin
chief cells
rate limiting step in carb digestion
hemosiderinurea and thrombosis
G cells

34. Superchiasmic nucleus
locus ceruleus
master clock for circadian rhythms
found in hairless skin
whats the V/Q at the apex of the lung

35. Chediak - Higashi
most common breast mass in pre - menopausal women
beta glucocerebrosidase
leydig cell tumor
child with partial albinism - peripherial neuropathy - recurrent infections

36. Aplastic anemia - rash - agranulocytosis
melanoma tumor marker
hallmark sign of COPD
propylthiouracil side effects
Galactocerebrosidase deficiency

37. Chocolate agar
brain tumor with fried egg appearance
H. flu
SICK PEG
eczema/recurrent infections/thrombocytopenia

38. Primary hyperaldosteronism (HTN - hypokalemia - metabolic alkalosis)

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39. Fibrates/statins
granulosa cell tumor secretes what?
cause of low pH vaginal discharge
SE: elevated LFTS - myositis
SE: facial flushing

40. CCK
pseudopalisading necrosis
adenomyosis
I cells
drug that blocks purine synthesis and is metabolized by xanthine oxidase

41. Hypoglycemia
probenecid
alpha galacosidase A
sulfonylureas side effect
hemangioblastomas of retina/cerebellum/medulla

42. Trigeminal
meissners
spike and dome on microscope
schwann cells
what nerve innervates the muscles of mastication?

43. Inner lining of ventricles - make CSF - originate from neuroectoderm
3 tumors of MEN 2a
ependymal cells
looks like fried eggs under histologic staining
LTB4

44. Bruton's agammaglobulinemia
defective tyrosine kinase
first line for cardiogenic shock
most common breast mass in pre - menopausal women
21 hydroxylase deficiency

45. Endometrial CA
resembles an onion in cross section
most common gyno malignancy
drug that blocks purine synthesis and is metabolized by xanthine oxidase
opioids antidote

46. Small diameter > large diameter; myelinated > unmyelinated
dose response curve change with competitive antagonist
order of nerve blockade
LMN signs
brain tumor with foamy cells and high vascularity

47. Bind viral gp41 subunit
heXosaminidase
cause of high pH vaginal discharge
barbituates withdrawal
fusion inhibitors

48. Dopamine
MPTP exposure causes depletion of what NT?
most common protozoal infection in US
What oncogene is a/w MEN 2a/b
sulfonylureas

49. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
sarcoma botyroides
SE: torsades de pointes
kluver bucy
shown to slow progression of diabetic neuropathy

50. Kawasaki
vasculitis of infants and children - involving coronary arteries
11 beta hydroxylase deficiency
schwann cells
failure of endodermal development