USMLE Pathophys

Instructions:

• Answer 50 questions in 15 minutes.
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• Match each statement with the correct term.
• Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Krabbe's
PGI2 (prostacyclin))
Galactocerebrosidase deficiency
locus ceruleus
antibiotic with SE of eosinophilia


2. Ach
alpha 1 anti - trypsin
most common testicular tumor in infants and children up to 3 years of age
basal nucleus of Meynert
what cells secrete somatostatin


3. HTN; masculinization
palisading nuclei - locally invasive
Conn's syndrome
hep B seropositivity in 30% of patients
11 beta hydroxylase deficiency


4. B. fragilis
hemangioblastomas of retina/cerebellum/medulla
opioids antidote
most common bacteria in GI tract
anti - mitochondrial antibodies


5. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
complete mole components
low dose ASA effects - intermediate dose - high dose
intranuclear inclusions seen in herpes simplex encephalitis
rate limiting step in carb digestion


6. Autosomal dominant
psammoma bodies
Galactocerebrosidase deficiency
inheritance pattern for all MENs
most common breast mass in pre - menopausal women


7. Panacinar
alpha 1 anti - trypsin
sclerosing adenosis
most common arrthymia
barbituates withdrawal


8. Macrolides
5 alpha reductase deficiency
dose response curve with noncompetitive antagonist
antibiotic with SE of eosinophilia
basal nucleus of Meynert


9. Bruton's agammaglobulinemia
schwann cells
vasculitis of infants and children - involving coronary arteries
defective tyrosine kinase
diphtheria treatment


10. Hurlers
corneal clouding & MR
testicular tumor that can present with gynecomastia
von Hippel Lindau disease
medial geniculate nucleus


11. SICK PEG
sclerosing adenosis
optically clear nuclei (orphan annie)
copper - arsenic - gold antidote
P450 Inhibitors


12. Ependymoma
blocks ADP receptors to inhibit platelet aggregation
currant jelly stool
brain tumor with perivascular pseudorosettes
cells destroyed in MS


13. Microglia
diphtheria treatment
form multinucleated giant cells in the CNS when infected with HIV
Lewy bodies composition
opioids antidote


14. Endometrial CA
most common gyno malignancy
eczema/recurrent infections/thrombocytopenia
protease inhibitors MofA
GFAP positive


15. Memory
pseudopalisading necrosis
most common bacteria in GI tract
hippocampus
strawberry tongue


16. Inhibits viral assembly
hydrocele
form multinucleated giant cells in the CNS when infected with HIV
glycine
protease inhibitors MofA


17. DiGeorge
polyhydramnios
leydig cell tumor
failure of endodermal development
first line for absence seizures


18. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
hemangioblastomas of retina/cerebellum/medulla
most common breast tumor in women under 25
sarcoma botyroides
eczema/recurrent infections/thrombocytopenia


19. PNH
brenner tumor
ovarian tumor with psammoma bodies
sclerosing adenosis
hemosiderinurea + thrombosis


20. Dubin Johnson
brain tumor with perivascular pseudorosettes
diphtheria treatment
dermatin sulfate accumulation
grossly black liver


21. Alpha feto protein
thromboxane A2
Yolk sac tumor produces...
astrocytes
LTB4


22. Seborric keratosis
most common first line agent for septic shock
keratin filled cysts
What thyroid pathology has an extremely tender thyroid gland
benzos antidote


23. Medulloblastoma
hep B seropositivity in 30% of patients
brain tumor with psammona bodies
homer wright rosettes
resembles an onion in cross section


24. Bilateral renal agenesis or posterior urethral valves in males
midshaft break of humerus
oligohydramnios
heXosaminidase
probenecid


25. Estrogen
anti - epithelial antibodies
t - PA - streptokinase antidote
hippocampus
cause of LH surge


26. Deficiency of aldosterone and cortisol


27. Decreased FEV/FVC ratio
hallmark sign of COPD
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
myelinates multiple CNS axons
antibiotic with SE of eosinophilia


28. Glucuronyl transferase
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
mildly decreased UDPGT
first line for absence seizures
enzyme used to conjugate bilirubin


29. Metachromatic leukodystrophy
eczema/recurrent infections/thrombocytopenia
lysosomal storage disease - demyelinating disease
11 beta hydroxylase deficiency
What thyroid pathology has an extremely tender thyroid gland


30. Increases platelet aggregation and vasoconstriction
brenner tumor
thromboxane A2
alpha 1 anti - trypsin
floppy mitral valve dissecting aortic aneurysm - berry aneurysm


31. Yolk sac
most common testicular tumor in infants and children up to 3 years of age
whats the V/Q at the base of the lung
HELLP syndrome
D cells


32. Dopamine
lysosomal storage disease - demyelinating disease
alpha galacosidase A
MPTP exposure causes depletion of what NT?
gram + bacteria that requires NAD and hemin for growth


33. Gastrin
complete mole components
G cells
anti - epithelial antibodies
may lead to multiple personalities


34. Secretin
S cells
11 beta hydroxylase deficiency
rabies
best effect of triglycerides/VLDL


35. Estrogen
which nerve lifts the eyelid?
most common primary cardiac tumor in kiddos
thromboxane A2
cause of increased myometrial excitability


36. Subacute (De Quervain's) thyroiditis
melanoma tumor marker
What thyroid pathology has an extremely tender thyroid gland
myelinates multiple CNS axons
11 beta hydroxylase deficiency


37. Oligosaccaride hydrolase
brain tumor with foamy cells and high vascularity
opioid withdrawal
rate limiting step in carb digestion
Bisphosphonates MofA


38. I- cell disease
deficiency of mannose phosphorylation
increased MCHC and hemolytic anemia
3 tumors of MEN 2a
ependymal cells


39. 6- MP
drug that blocks purine synthesis and is metabolized by xanthine oxidase
mildly decreased UDPGT
treatment for SIADH
LT C4 D4 E4


40. 5- fluorouracil
thymidylate synthase
lysosomal storage disease a/w renal disease
most common arrthymia
Where does the lateral corticospinal decussate?


41. Sends autonomic fibers to heart
G cells
most common primary cardiac tumor in kiddos
dorsal motor nucleus
colchicine


42. Brenners tumor
nucleoside reverse transcriptase inhibitors
ovarian tumor that resembles bladder epithelium
most common primary cardiac tumor in kiddos
may lead to multiple personalities


43. Obstructive - COPD
optically clear nuclei (orphan annie)
iduronidase sulfatase
catalase negative
pt has extended expiratory phase


44. Parathyroid - pituitary - pancreatic
Lewy bodies composition
3 tumors of MEN 1
protease inhibitors MofA
etanercept


45. Hurlers - Hunters
Addison's
von Hippel Lindau disease
whats the V/Q at the apex of the lung
dermatin sulfate accumulation


46. Gauchers
alpha L iduronidase
most common lysosomal storage disease
ventral posterior nucleus - medial part
most common testicular tumor


47. Ovarian bengin tumor...looks like bladder
thyroid cancer associtated with RET oncogene
benzos antidote
best effect on HDL
brenner tumor


48. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
thayer martin media
PGI2 (prostacyclin))
mildly decreased UDPGT
LT C4 D4 E4


49. Demeclycocycline or water restriction
treatment for SIADH
What thyroid pathology has an extremely tender thyroid gland
antibiotic with SE of eosinophilia
midshaft break of humerus


50. Rhabdomyoma
most common primary cardiac tumor in kiddos
dorsal motor nucleus
epithelial
spike and dome on microscope