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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Primary hyperaldosteronism (HTN - hypokalemia - metabolic alkalosis)

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2. Achondroplasia
sphingomyelinase deficiency
What oncogene is a/w MEN 2a/b
what inhibits prolactin secretion
FGFR3 mutation

3. 5- fluorouracil
SE: elevated LFTS - myositis
myelinates on PNS
thymidylate synthase
most common breast mass in postmenopausal women

4. Increases platelet aggregation and vasoconstriction
thromboxane A2
may lead to multiple personalities
VA/VL
best effect on HDL

5. Anxiety - seizures - delirium - life threatening CV collapse
iduronidase sulfatase
barbituates withdrawal
papillary thyroid cancer
sturge weber syndrome

6. 2 sperm + 1 egg (fetal parts present)
partial mole components
ambiguous nucleus
LTB4
antibiotic with SE of eosinophilia

7. Weakness - atrophy - fasiculations - decreased reflexes & tone
LMN signs
hippocampus
most common first line agent for septic shock
GM2 ganglioside accumulation

8. Decreases conversion
partial mole components
VA/VL
PTU
currant jelly stool

9. Clopidogrel - ticoplidine
kawasaki
grossly black liver
brain tumor with foamy cells and high vascularity
blocks ADP receptors to inhibit platelet aggregation

10. Brenners tumor
Schiller Duval bodies
smoking emphysema
ovarian tumor that resembles bladder epithelium
medial geniculate nucleus

11. Medulloblastoma
found in hairless skin
treatment of malignant hyperthermia
homer wright rosettes
macrolides use (PUS)

12. Gonorrhea
thayer martin media
infliximab
LTB4
Schiller Duval bodies

13. Tay Sachs
GM2 ganglioside accumulation
3 tumors of MEN 2b
heparin antidote
chief cells

14. SICK PEG
most common lysosomal storage disease
honey crusted lesions common around nose/lips
LMN signs
P450 Inhibitors

15. Membranoproliferative GN
mildly decreased UDPGT
most common primary cardiac tumor in kiddos
VA/VL
tram - track on microscope

16. Oligosaccaride hydrolase
most common first line agent for septic shock
rate limiting step in carb digestion
vasculitis of infants and children - involving coronary arteries
What are the hormone changes seen in menopause

17. Panacinar
alpha 1 anti - trypsin
vasculitis a/w Hep B
dose response curve with noncompetitive antagonist
cancer associated with Hashimoto's thyroiditis

18. Dantrolene (prevents release of calcium from SR of muscle)
colchicine
dermatin sulfate accumulation
treatment of malignant hyperthermia
follicular

19. Cause release of preformed insulin
ventral posterior nucleus - medial part
may lead to multiple personalities
sulfonylureas
preeclampsia

20. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
TZD (glitazones) MofA
protease inhibitors MofA
thromboxane A2
low dose ASA effects - intermediate dose - high dose

21. Somatostatin
D cells
grossly black liver
currant jelly stool
whats the V/Q at the base of the lung

22. Oculomotor
rabies
What thyroid pathology has an extremely tender thyroid gland
most common breast cancer
which nerve lifts the eyelid?

23. Obstructive - COPD
hep B seropositivity in 30% of patients
brain tumor a/w von hipple - linadu syndrome
pt has extended expiratory phase
ventral posterior nucleus - medial part

24. Hairless skin - dynamic fine touch
hemosiderinurea and thrombosis
alpha L iduronidase
meissners
most common breast mass in pre - menopausal women

25. Posterior communicating - posterior cerebral - anterior choroidal arteries
blood supply for thalamus
pigmented iris hamartomas - neural tumors
found in hairless skin
GFAP positive

26. Chocolate agar
H. flu
most common breast tumor in women under 25
heXosaminidase
catalase negative

27. Demeclycocycline or water restriction
treatment for SIADH
Where does the lateral corticospinal decussate?
most common breast mass in pre - menopausal women
iduronidase sulfatase

28. NE
locus ceruleus
what meds treat malaria
etanercept
currant jelly stool

29. Decreased FEV/FVC ratio
I cells
hallmark sign of COPD
whats the V/Q at the base of the lung
copper - arsenic - gold antidote

30. Fabry's & Hunters
x- linked recessive lysosomal storage diseases
D cells
Yolk sac tumor produces...
sulfonylureas side effect

31. Gastrin
erythema nodosum
most common breast tumor in women under 25
G cells
sulfonylureas side effect

32. Basal cell carcinoma
palisading nuclei - locally invasive
3 tumors of MEN 2a
P450 Inhibitors
nucleoside reverse transcriptase inhibitors

33. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
TZD (glitazones) MofA
lysosomal storage disease - demyelinating disease
master clock for circadian rhythms
iduronidase sulfatase

34. Antitoxin - penicillin - DPT vaccine
rate limiting step in carb digestion
optically clear nuclei (orphan annie)
diphtheria treatment
most common breast cancer

35. Fibrates/statins
drug induced lupus
G cells
SE: elevated LFTS - myositis
what inhibits prolactin secretion

36. Lactic acidosis
absent UTPGT
metformin side effect
brain tumor with fried egg appearance
11 beta hydroxylase deficiency

37. Hypoglycemia
tumor composed of cytotrophoblasts and syncytiotrophoblasts
sulfonylureas side effect
17 alpha hydroxylase deficiency
cancer associated with Hashimoto's thyroiditis

38. Oligodendoglia
SE: facial flushing
neutrophils fail to respond to chemotaxic stimuli
alpha L iduronidase
myelinates multiple CNS axons

39. Naloxone/naltrexone
lysosomal storage disease a/w renal disease
opioids antidote
brain tumor with fried egg appearance
anti - mitochondrial antibodies

40. Papillary CA of thyroid
subluxation of lens
propylthiouracil side effects
best effect on HDL
optically clear nuclei (orphan annie)

41. BCG PQRS
sulfonylureas side effect
drug induced lupus
P450 inducers
defective tyrosine kinase

42. Niacin
SE: facial flushing
contains ovarian vessels
absent UTPGT
strawberry tongue

43. Secretin
S cells
MofA of N- aceylcysteine
GABA - glutamine
grossly black liver

44. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
most common lysosomal storage disease
optically clear nuclei (orphan annie)
SE: elevated LFTS - myositis
LTB4

45. Subacute (De Quervain's) thyroiditis
mitral valve prolapse - liver diseae - berry aneurysm
ovarian tumor with elevate hCG
What thyroid pathology has an extremely tender thyroid gland
what checkpoint is p53 involved with?

46. Babinski - weakness - increased reflexes & tone - spastic paralysis
UMN signs
vasculitis of infants and children - involving coronary arteries
medial geniculate nucleus
raphe nucleus

47. Aminocaproic acid
hallmark sign of COPD
dermatin sulfate accumulation
microglia
t - PA - streptokinase antidote

48. S-100
opioids antidote
melanoma tumor marker
first line for cardiogenic shock
Galactocerebrosidase deficiency

49. Glioblastoma multiforme
hemangioblastomas of retina/cerebellum/medulla
cells destroyed in Guillain Barre
lysosomal storage disease a/w renal disease
pseudopalisading necrosis

50. Protamine sulfate
hydatidiform mole with crazy high hCG
beta glucocerebrosidase
catalase positive coagulase negative
heparin antidote