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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Hurlers
hemangioblastomas of retina/cerebellum/medulla
keratin filled cysts
corneal clouding & MR
pseudopalisading necrosis

2. Inner lining of ventricles - make CSF - originate from neuroectoderm
hippocampus
basal nucleus of Meynert
brain tumor a/w von hipple - linadu syndrome
ependymal cells

3. Fibrocystic
most common breast mass in pre - menopausal women
contains ovarian vessels
strawberry tongue
hydatidiform mole with crazy high hCG

4. Benign - contains Reinke crystals - usually androgen producing
papillary thyroid cancer
brain tumor a/w von hipple - linadu syndrome
I cells
leydig cell tumor

5. Antitoxin - penicillin - DPT vaccine
What artery causes locked in syndrome
diphtheria treatment
pseudopalisading necrosis
Where does the spinothalamic decussate?

6. Choriocarcinoma or dysgerminoma
leydig cell tumor
eczema/recurrent infections/thrombocytopenia
enzyme used to conjugate bilirubin
ovarian tumor with elevate hCG

7. Cocain and sumatriptan
what nerve innervates the muscles of mastication?
What causes coronary vasospasm as a SE?
HELLP syndrome
ovarian tumor with psammoma bodies

8. Rheumatic fever
brain tumor with foamy cells and high vascularity
protease inhibitors MofA
hep B seropositivity in 30% of patients
Aschoff bodies

9. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
opioid withdrawal
LMN signs
PGI2 (prostacyclin))
palisading nuclei - locally invasive

10. Alpha synuclein
sulfonylureas side effect
lewy body composition
placenta previa
hydrocele

11. Makes ADH
neutrophils fail to respond to chemotaxic stimuli
increased MCHC and hemolytic anemia
supraoptic nucleus of hypothalamus
absent UTPGT

12. Estrogen
failure of endodermal development
brain tumor with psammona bodies
brain tumor a/w von hipple - linadu syndrome
cause of increased myometrial excitability

13. Estrogen
polyhydramnios
cause of LH surge
Conn's syndrome
tumor with call - exner bodies

14. SCID
failure of endodermal development
sulfonylureas MofA
infliximab
child with eczema - coarse facial features - cold abscesses

15. Invasive ductal
lewy body composition
brenner tumor
most common breast cancer
gram + bacteria that requires NAD and hemin for growth

16. Leydig cell tumor
LT C4 D4 E4
testicular tumor that can present with gynecomastia
beta glucocerebrosidase
sulfonylureas

17. Visceral sensory
ovarian tumor with psammoma bodies
papillary thyroid cancer
solitarius nucleus
absent UTPGT

18. Regenerates glutathione
benzos antidote
MofA of N- aceylcysteine
thyroid cancer associtated with RET oncogene
pigmented iris hamartomas - neural tumors

19. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
may lead to multiple personalities
What hormones share a common alpha subunit
erythema nodosum
What artery causes locked in syndrome

20. Panacinar
what meds treat malaria
cancer associated with Hashimoto's thyroiditis
alpha 1 anti - trypsin
schwann cells

21. Masculinization - hypovolemic shock
SE: elevated LFTS - myositis
infliximab
GFAP positive
21 hydroxylase deficiency

22. Alpha synuclein
most common testicular tumor in infants and children up to 3 years of age
honey crusted lesions common around nose/lips
Lewy bodies composition
absent UTPGT

23. Suspensory ligament of ovaries
sarcoma botyroides
nucleoside reverse transcriptase inhibitors
most common testicular tumor in infants and children up to 3 years of age
contains ovarian vessels

24. Second most common type of thyroid cancer
brain tumor with foamy cells and high vascularity
dose response curve change with competitive antagonist
follicular
propylthiouracil side effects

25. Centriacinar
SE: facial flushing
smoking emphysema
first line for cardiogenic shock
dose response curve change with competitive antagonist

26. Chediak - Higashi
medial geniculate nucleus
tram - track on microscope
SICK PEG
child with partial albinism - peripherial neuropathy - recurrent infections

27. Imabtinib
gram + bacteria that requires NAD and hemin for growth
antibody against philadelphia chromosome
G cells
most common breast tumor in women under 25

28. Bruton's agammaglobulinemia
propylthiouracil side effects
pseudopalisading necrosis
preeclampsia
defective tyrosine kinase

29. Inhibits osteoclastic activity
child with eczema - coarse facial features - cold abscesses
Bisphosphonates MofA
brain tumor with psammona bodies
von Hippel Lindau disease

30. Ovarian bengin tumor...looks like bladder
brenner tumor
sarcoma botyroides
dermatin sulfate accumulation
crinkled paper cytoplasm

31. Demeclycocycline or water restriction
currant jelly stool
treatment for SIADH
brain tumor with foamy cells and high vascularity
brain tumor with perivascular pseudorosettes

32. Fibrates
follicular
macrolides use (PUS)
SE: elevated LFTS - myositis
best effect of triglycerides/VLDL

33. Ethosuximide
first line for absence seizures
VA/VL
ovarian tumor that resembles bladder epithelium
whats the V/Q at the base of the lung

34. H. Influenza
rabies
resembles an onion in cross section
gram + bacteria that requires NAD and hemin for growth
vasculitis of infants and children - involving coronary arteries

35. Neurofibromatosis
lisch nodules
most common breast tumor in women under 25
probenecid
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

36. Oculomotor
G cells
benzos antidote
cause of increased myometrial excitability
which nerve lifts the eyelid?

37. Parathyroid - pituitary - pancreatic
3 tumors of MEN 1
oligodendrioglia
Yolk sac tumor produces...
microglia

38. Protamine sulfate
enzyme used to conjugate bilirubin
resembles an onion in cross section
heparin antidote
PGI2 (prostacyclin))

39. Damaged in multiple sclerosis
catalase positive coagulase negative
oligohydramnios
oligodendrioglia
21 hydroxylase deficiency

40. Invasive ductal CA
intranuclear inclusions seen in herpes simplex encephalitis
order of nerve blockade
most common breast mass in postmenopausal women
nucleoside reverse transcriptase inhibitors

41. Hurlers - Hunters
schwann cells
TZD (glitazones) MofA
optically clear nuclei (orphan annie)
dermatin sulfate accumulation

42. Ependymoma
tumor composed of cytotrophoblasts and syncytiotrophoblasts
child with eczema - coarse facial features - cold abscesses
sumatriptan
brain tumor with perivascular pseudorosettes

43. Decreased potency - increased Km
which nerve lifts the eyelid?
3 tumors of MEN 2a
dose response curve change with competitive antagonist
ventral posterior nucleus - medial part

44. Endometrial glands inside myometrium
HELLP syndrome
hippocampus
most common protozoal infection in US
adenomyosis

45. Actinomyces
currant jelly stool
placenta previa
branching rods on oral infection
sarcoma botyroides

46. Polyarteritis nodosa
vasculitis a/w Hep B
ependymal cells
heXosaminidase
Aschoff bodies

47. Dubin Johnson
PTU
contains ovarian vessels
first line for cardiogenic shock
grossly black liver

48. Medullary
parietal cells
Aschoff bodies
oligohydramnios
cancer arising from parafollicular C cells

49. Marfans
raphe nucleus
microglia
macrolides use (PUS)
floppy mitral valve dissecting aortic aneurysm - berry aneurysm

50. Medulla
papillary thyroid cancer
blocks ADP receptors to inhibit platelet aggregation
Where does the lateral corticospinal decussate?
cancer associated with Hashimoto's thyroiditis