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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Antitoxin - penicillin - DPT vaccine
diphtheria treatment
what nerve innervates the muscles of mastication?
most common bacteria in GI tract
What are the hormone changes seen in menopause

2. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
3 tumors of MEN 2b
thayer martin media
diphtheria treatment
drug induced lupus

3. Schwann cells
locus ceruleus
SICK PEG
myelinates on PNS
testicular tumor that can present with gynecomastia

4. Demeclycocycline or water restriction
hemosiderinurea and thrombosis
treatment for SIADH
most common arrthymia
thyroid cancer associtated with RET oncogene

5. Medulloblastoma
probenecid
low dose ASA effects - intermediate dose - high dose
homer wright rosettes
D cells

6. 6- MP
MofA of N- aceylcysteine
schwann cells
nucleoside reverse transcriptase inhibitors
drug that blocks purine synthesis and is metabolized by xanthine oxidase

7. Homocystienuria - Marfans
sturge weber syndrome
TZD (glitazones) MofA
low dose ASA effects - intermediate dose - high dose
subluxation of lens

8. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
D cells
vasculitis a/w Hep B
sulfonylureas MofA
hydatidiform mole with crazy high hCG

9. Tay Sachs
von Hippel Lindau disease
basal nucleus of Meynert
GM2 ganglioside accumulation
probenecid

10. Visceral sensory
erythema nodosum
copper - arsenic - gold antidote
solitarius nucleus
FGFR3 mutation

11. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
chief cells
3 tumors of MEN 1
schwann cells
psammoma bodies

12. Ret
17 alpha hydroxylase deficiency
most common breast mass in pre - menopausal women
What oncogene is a/w MEN 2a/b
dose response curve with noncompetitive antagonist

13. Masculinization - hypovolemic shock
21 hydroxylase deficiency
barbituates withdrawal
hallmark sign of COPD
copper - arsenic - gold antidote

14. H. Influenza
gram + bacteria that requires NAD and hemin for growth
HELLP syndrome
failure of endodermal development
most common arrthymia

15. Dissociative
may lead to multiple personalities
Yolk sac tumor produces...
Shigella
ventral posterior nucleus - medial part

16. SICK PEG
lysosomal storage disease a/w renal disease
gram + bacteria that requires NAD and hemin for growth
probenecid
P450 Inhibitors

17. Decreased efficacy - decreased Vmax
dose response curve with noncompetitive antagonist
plenta accreta
17 alpha hydroxylase deficiency
blocks ADP receptors to inhibit platelet aggregation

18. Negri bodies
locus ceruleus
rabies
midshaft break of humerus
von Hippel Lindau disease

19. Second most common type of thyroid cancer
follicular
strawberry tongue
homer wright rosettes
granulosa cell tumor secretes what?

20. Hereditary spherocytosis
hemosiderinurea and thrombosis
ventral posterior nucleus - medial part
von Hippel Lindau disease
increased MCHC and hemolytic anemia

21. Trichomonas - Giardia
most common primary cardiac tumor in kiddos
most common protozoal infection in US
most common breast cancer
most common gyno malignancy

22. Medulla
sulfonylureas side effect
basal nucleus of Meynert
barbituates withdrawal
Where does the dorsal column decussate?

23. Lymphoma

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24. Oculomotor
which nerve lifts the eyelid?
lewy body composition
what cells secrete somatostatin
What causes coronary vasospasm as a SE?

25. Achondroplasia
child with partial albinism - peripherial neuropathy - recurrent infections
FGFR3 mutation
sarcoma botyroides
subluxation of lens

26. Gonorrhea
thayer martin media
oligohydramnios
MofA of N- aceylcysteine
parietal cells

27. Small diameter > large diameter; myelinated > unmyelinated
order of nerve blockade
dose response curve change with competitive antagonist
plenta accreta
etanercept

28. Rhabdomyoma
most common primary cardiac tumor in kiddos
locus ceruleus
GM2 ganglioside accumulation
cancer arising from parafollicular C cells

29. Cause release of preformed insulin
most common primary cardiac tumor in kiddos
may lead to multiple personalities
sulfonylureas
VA/VL

30. Chronic gout. inhibits reabsorbtion of uric acid in PCT
hydrocele
probenecid
partial mole components
anti - platelet antibodies

31. Ach
basal nucleus of Meynert
hydrocele
myelinates on PNS
21 hydroxylase deficiency

32. Glioblastoma multiforme
pseudopalisading necrosis
most common first line agent for septic shock
FGFR3 mutation
chromosome 4

33. Regenerates glutathione
may lead to multiple personalities
sulfonylureas MofA
MofA of N- aceylcysteine
subluxation of lens

34. ACE inhibitors
papillary thyroid cancer
hydatidiform mole with crazy high hCG
shown to slow progression of diabetic neuropathy
H. flu

35. Seborric keratosis
glycine
keratin filled cysts
eczema/recurrent infections/thrombocytopenia
brain tumor with foamy cells and high vascularity

36. Causes vasoconstriction (use for acute migraines)
sumatriptan
best effect of triglycerides/VLDL
granulosa cell tumor secretes what?
crinkled paper cytoplasm

37. Decreased potency - increased Km
testicular tumor that can present with gynecomastia
neutrophils fail to respond to chemotaxic stimuli
medial geniculate nucleus
dose response curve change with competitive antagonist

38. Subacute (De Quervain's) thyroiditis
defective tyrosine kinase
GFAP positive
What thyroid pathology has an extremely tender thyroid gland
LTB4

39. Meissner
found in hairless skin
abruptio placentae
follicular
absent UTPGT

40. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
what meds treat malaria
kawasaki
tumor with call - exner bodies
opioid withdrawal

41. Inhibitory in the SC
cancer arising from parafollicular C cells
hemangioblastomas of retina/cerebellum/medulla
glycine
thayer martin media

42. Naloxone/naltrexone
testicular tumor that can present with gynecomastia
opioids antidote
Where does the lateral corticospinal decussate?
homer wright rosettes

43. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
bocks PRPP synthetase to block purine synthesis
hydrocele
probenecid
erythema nodosum

44. Chocolate agar
H. flu
bocks PRPP synthetase to block purine synthesis
lisch nodules
etanercept

45. Leydig cell tumor
hemosiderinurea + thrombosis
testicular tumor that can present with gynecomastia
3 tumors of MEN 2a
Where does the dorsal column decussate?

46. Hemolysis - elevated LFTs - Low Platelets
oligohydramnios
probenecid
HELLP syndrome
Where does the dorsal column decussate?

47. Hemangioblastoma
brain tumor with foamy cells and high vascularity
hemangioblastomas of retina/cerebellum/medulla
SE: elevated LFTS - myositis
paraventricular nucleus of hypothalamus

48. Hurlers
psammoma bodies
D cells
resembles an onion in cross section
alpha L iduronidase

49. Papillary
most common breast mass in postmenopausal women
3 tumors of MEN 1
thyroid cancer associtated with RET oncogene
cause of malignant hyperthermia

50. Microglia
leydig cell tumor
form multinucleated giant cells in the CNS when infected with HIV
thyroid cancer associtated with RET oncogene
child with eczema - coarse facial features - cold abscesses