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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Achondroplasia
leydig cell tumor
FGFR3 mutation
most common breast mass in postmenopausal women
hep B seropositivity in 30% of patients

2. Gilberts
LMN signs
what cells secrete somatostatin
heparin antidote
mildly decreased UDPGT

3. Job's or LAD
pt has extended expiratory phase
benzos antidote
tumor composed of cytotrophoblasts and syncytiotrophoblasts
neutrophils fail to respond to chemotaxic stimuli

4. Membranous GN
child with partial albinism - peripherial neuropathy - recurrent infections
increased MCHC and hemolytic anemia
spike and dome on microscope
SE: elevated LFTS - myositis

5. Niacin
SE: facial flushing
brain tumor with psammona bodies
ambiguous nucleus
contains ovarian vessels

6. Parathyroid - pituitary - pancreatic
cells destroyed in MS
mitral valve prolapse - liver diseae - berry aneurysm
resembles an onion in cross section
3 tumors of MEN 1

7. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
Aschoff bodies
3 tumors of MEN 1
colchicine
absent UTPGT

8. Granulosa cell tumor
tumor with call - exner bodies
SE: elevated LFTS - myositis
solitarius nucleus
low dose ASA effects - intermediate dose - high dose

9. Basilar
What artery causes locked in syndrome
11 beta hydroxylase deficiency
myelinates multiple CNS axons
which nerve lifts the eyelid?

10. Von Hippel Lindau
increased MCHC and hemolytic anemia
hemangioblastomas of retina/cerebellum/medulla
Schiller Duval bodies
defective tyrosine kinase

11. Brenners tumor
SE: torsades de pointes
G cells
ovarian tumor that resembles bladder epithelium
vasculitis of infants and children - involving coronary arteries

12. Papillary CA of thyroid
hemosiderinurea + thrombosis
optically clear nuclei (orphan annie)
cause of increased myometrial excitability
lysosomal storage disease a/w renal disease

13. Yolk sac tumor
Addison's
Schiller Duval bodies
midshaft break of humerus
whats the V/Q at the base of the lung

14. TNF receptor
MofA of N- aceylcysteine
corneal clouding & MR
etanercept
glycine

15. Papillary
thyroid cancer associtated with RET oncogene
pigmented iris hamartomas - neural tumors
GFAP positive
may lead to multiple personalities

16. Vibration - pressure
PTU
smoking emphysema
blocks ADP receptors to inhibit platelet aggregation
pacinian

17. HTN; masculinization
ependymal cells
VA/VL
adenomyosis
11 beta hydroxylase deficiency

18. Combo of inhaled anesthetics & succinylcholine
opioids antidote
cause of malignant hyperthermia
first line for cardiogenic shock
probenecid

19. 6- MP
best effect of triglycerides/VLDL
medial geniculate nucleus
most common bacteria in GI tract
drug that blocks purine synthesis and is metabolized by xanthine oxidase

20. Macrophages of the CNS
lewy body composition
microglia
tumor with call - exner bodies
grossly black liver

21. ADPKD
mitral valve prolapse - liver diseae - berry aneurysm
palisading nuclei - locally invasive
brain tumor with psammona bodies
dorsal motor nucleus

22. Posterior communicating - posterior cerebral - anterior choroidal arteries
blood supply for thalamus
MofA Levothyroxine
PTU
kawasaki

23. Primary biliary cirrhosis
Where does the spinothalamic decussate?
anti - mitochondrial antibodies
most common breast cancer
complete mole components

24. Causes vasoconstriction (use for acute migraines)
locus ceruleus
glycine
plenta accreta
sumatriptan

25. Metachromatic leukodystrophy
grossly black liver
lysosomal storage disease - demyelinating disease
increased MCHC and hemolytic anemia
honey crusted lesions common around nose/lips

26. Tay SaX
GM2 ganglioside accumulation
psammoma bodies
heXosaminidase
probenecid

27. Ret
mitral valve prolapse - liver diseae - berry aneurysm
What oncogene is a/w MEN 2a/b
LT C4 D4 E4
kawasaki

28. Serotonin
FGFR3 mutation
ambiguous nucleus
pt has extended expiratory phase
raphe nucleus

29. Hunters
pacinian
lysosomal storage disease - demyelinating disease
iduronidase sulfatase
rabies

30. Invasive ductal
alpha L iduronidase
locus ceruleus
most common breast cancer
diphtheria treatment

31. DiGeorge
Yolk sac tumor produces...
sulfonylureas
failure of endodermal development
branching rods on oral infection

32. Choriocarcinoma or dysgerminoma
Where does the spinothalamic decussate?
cough - conjunctivitis - coryza - fever
whats the V/Q at the base of the lung
ovarian tumor with elevate hCG

33. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
dorsal motor nucleus
LTB4
inheritance pattern for all MENs
LMN signs

34. Alpha synuclein
etanercept
epithelial
Lewy bodies composition
Galactocerebrosidase deficiency

35. Amygdala
kluver bucy
placenta previa
found in hairless skin
hydatidiform mole with crazy high hCG

36. Macconkey's agar
blocks ADP receptors to inhibit platelet aggregation
treatment of malignant hyperthermia
Shigella
ovarian tumor that resembles bladder epithelium

37. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
melanoma tumor marker
kawasaki
17 alpha hydroxylase deficiency
catalase positive coagulase negative

38. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
von Hippel Lindau disease
intranuclear inclusions seen in herpes simplex encephalitis
granulosa cell tumor secretes what?
erythema nodosum

39. Oligodendrioma
Addison's
crinkled paper cytoplasm
P450 Inhibitors
brain tumor with fried egg appearance

40. Rhabdomyoma
What hormones share a common alpha subunit
von Hippel Lindau disease
most common primary cardiac tumor in kiddos
catalase negative

41. Deficiency of aldosterone and cortisol

42. Oculomotor
brenner tumor
which nerve lifts the eyelid?
shown to slow progression of diabetic neuropathy
what meds treat malaria

43. Krabbe's
Galactocerebrosidase deficiency
grossly black liver
preeclampsia
may lead to multiple personalities

44. 2 sperm + 1 egg (fetal parts present)
plenta accreta
partial mole components
PGI2 (prostacyclin))
sumatriptan

45. Marfans
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
drug that blocks purine synthesis and is metabolized by xanthine oxidase
contains ovarian vessels
defective tyrosine kinase

46. Staph epidermidis - staph sapro
catalase positive coagulase negative
colchicine
midshaft break of humerus
PGI2 (prostacyclin))

47. Leydig cell tumor
cancer arising from parafollicular C cells
testicular tumor that can present with gynecomastia
cause of malignant hyperthermia
antibiotic with SE of eosinophilia

48. Small diameter > large diameter; myelinated > unmyelinated
branching rods on oral infection
what meds treat malaria
alpha 1 anti - trypsin
order of nerve blockade

49. Measles
lewy body composition
resembles an onion in cross section
testicular tumor that can present with gynecomastia
cough - conjunctivitis - coryza - fever

50. Increased acini and intralobular fibrosis
sclerosing adenosis
most common arrthymia
pt has extended expiratory phase
What causes coronary vasospasm as a SE?