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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
3 tumors of MEN 2b
contains ovarian vessels
nucleoside reverse transcriptase inhibitors
child with eczema - coarse facial features - cold abscesses

2. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
sarcoma botyroides
sulfonylureas side effect
drug that blocks purine synthesis and is metabolized by xanthine oxidase
cause of LH surge

3. Seborric keratosis
What oncogene is a/w MEN 2a/b
best effect on HDL
keratin filled cysts
catalase positive coagulase negative

4. Chediak - Higashi
pigmented iris hamartomas - neural tumors
pseudopalisading necrosis
child with partial albinism - peripherial neuropathy - recurrent infections
SE: torsades de pointes

5. Endometrial glands inside myometrium
strawberry tongue
metformin side effect
adenomyosis
PTU

6. Benign - contains Reinke crystals - usually androgen producing
absent UTPGT
leydig cell tumor
cancer arising from parafollicular C cells
barbituates withdrawal

7. Basilar
17 alpha hydroxylase deficiency
propylthiouracil side effects
What artery causes locked in syndrome
currant jelly stool

8. Hereditary spherocytosis
testicular tumor that can present with gynecomastia
SE: facial flushing
fusion inhibitors
increased MCHC and hemolytic anemia

9. Pemphigus vulgaris
erythema nodosum
strawberry tongue
hemosiderinurea and thrombosis
anti - epithelial antibodies

10. Secretin
crinkled paper cytoplasm
dose response curve with noncompetitive antagonist
S cells
oligohydramnios

11. Oligodendrogila
infliximab
melanoma tumor marker
ovarian tumor that resembles bladder epithelium
cells destroyed in MS

12. Motor innervation of pharynx - larynx and upper esophagus
pseudopalisading necrosis
ambiguous nucleus
raphe nucleus
GFAP positive

13. Astrocytoma & glioblastoma multiforme
cells destroyed in MS
Conn's syndrome
GM2 ganglioside accumulation
GFAP positive

14. I- cell disease
vasculitis a/w Hep B
Where does the lateral corticospinal decussate?
deficiency of mannose phosphorylation
most common breast cancer

15. Niacin
SE: facial flushing
optically clear nuclei (orphan annie)
ambiguous nucleus
What are the hormone changes seen in menopause

16. Fibrocystic
most common breast mass in pre - menopausal women
Where does the lateral corticospinal decussate?
ambiguous nucleus
brain tumor with psammona bodies

17. Aminocaproic acid
solitarius nucleus
first line for absence seizures
t - PA - streptokinase antidote
Schiller Duval bodies

18. Atrial fibrillation
most common breast mass in postmenopausal women
most common arrthymia
first line for absence seizures
treatment of malignant hyperthermia

19. Leydig cell tumor
lead antidote
testicular tumor that can present with gynecomastia
VA/VL
lisch nodules

20. Rhabdomyoma
precursor to GABA
most common primary cardiac tumor in kiddos
ovarian tumor with elevate hCG
deficiency of mannose phosphorylation

21. Flumazenil
brain tumor with fried egg appearance
melanoma tumor marker
benzos antidote
precursor to GABA

22. Serotonin
cause of LH surge
strawberry tongue
raphe nucleus
lysosomal storage disease a/w renal disease

23. Ach
Abciximab
complete mole components
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
basal nucleus of Meynert

24. Rheumatic fever
21 hydroxylase deficiency
antibiotic with SE of eosinophilia
Aschoff bodies
Addison's

25. D cells of pancreas and gut
LMN signs
hemosiderinurea + thrombosis
what cells secrete somatostatin
S cells

26. SICK PEG
P450 Inhibitors
PTU
MPTP exposure causes depletion of what NT?
FGFR3 mutation

27. Memory
whats the V/Q at the apex of the lung
papillary thyroid cancer
hippocampus
G cells

28. Inhibits osteoclastic activity
GM2 ganglioside accumulation
probenecid
papillary thyroid cancer
Bisphosphonates MofA

29. Brenners tumor
HELLP syndrome
ovarian tumor that resembles bladder epithelium
catalase positive coagulase negative
LT C4 D4 E4

30. Centriacinar
smoking emphysema
Lewy bodies composition
currant jelly stool
first line for absence seizures

31. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
drug induced lupus
alpha 1 anti - trypsin
iduronidase sulfatase
astrocytes

32. Babinski - weakness - increased reflexes & tone - spastic paralysis
polyhydramnios
basal nucleus of Meynert
UMN signs
3 tumors of MEN 2a

33. Medulla
whats the V/Q at the base of the lung
SE: facial flushing
Where does the dorsal column decussate?
drug induced lupus

34. S-100
LTB4
most common breast cancer
kawasaki
melanoma tumor marker

35. Medullary thyroid - pheochromocytoma - parathryoid
3 tumors of MEN 2a
propylthiouracil side effects
BCG PQRS
GFAP positive

36. Dopamine
MPTP exposure causes depletion of what NT?
propylthiouracil side effects
locus ceruleus
hep B seropositivity in 30% of patients

37. Fabry's & Hunters
drug that blocks purine synthesis and is metabolized by xanthine oxidase
x- linked recessive lysosomal storage diseases
branching rods on oral infection
TZD (glitazones) MofA

38. Hypoglycemia
I cells
sulfonylureas side effect
H. flu
what checkpoint is p53 involved with?

39. Inhibits viral assembly
protease inhibitors MofA
solitarius nucleus
Where does the lateral corticospinal decussate?
brenner tumor

40. Increased acini and intralobular fibrosis
benzos antidote
basal nucleus of Meynert
sclerosing adenosis
SE: torsades de pointes

41. Antitoxin - penicillin - DPT vaccine
protease inhibitors MofA
lewy body composition
most common protozoal infection in US
diphtheria treatment

42. Makes oxytocin
paraventricular nucleus of hypothalamus
infliximab
solitarius nucleus
hep B seropositivity in 30% of patients

43. Cause release of preformed insulin
pseudopalisading necrosis
partial mole components
sulfonylureas
best effect of triglycerides/VLDL

44. Cocain and sumatriptan
UMN signs
mildly decreased UDPGT
What are the hormone changes seen in menopause
What causes coronary vasospasm as a SE?

45. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
TZD (glitazones) MofA
found in hairless skin
MofA of N- aceylcysteine
21 hydroxylase deficiency

46. Prevents incorporation into host DNA
epithelial
brain tumor with fried egg appearance
nucleoside reverse transcriptase inhibitors
G cells

47. Hemangioblastoma
sturge weber syndrome
brain tumor with foamy cells and high vascularity
complete mole components
homer wright rosettes

48. Somatostatin
PGI2 (prostacyclin))
astrocytes
cells destroyed in Guillain Barre
D cells

49. NF 1
treatment of malignant hyperthermia
pigmented iris hamartomas - neural tumors
Where does the lateral corticospinal decussate?
basal nucleus of Meynert

50. Streptococcus
partial mole components
catalase negative
HELLP syndrome
most common lysosomal storage disease