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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Polyarteritis nodosa
cause of low pH vaginal discharge
papillary thyroid cancer
hep B seropositivity in 30% of patients
cause of LH surge

2. Negri bodies
probenecid
rabies
contains ovarian vessels
tram - track on microscope

3. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
sarcoma botyroides
most common arrthymia
brenner tumor
best effect of triglycerides/VLDL

4. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
sulfonylureas MofA
hippocampus
locus ceruleus
found in hairless skin

5. Actinomyces
3 tumors of MEN 2b
ovarian tumor that resembles bladder epithelium
branching rods on oral infection
G cells

6. Polyarteritis nodosa
most common breast mass in postmenopausal women
vasculitis a/w Hep B
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
dose response curve with noncompetitive antagonist

7. Oligodendroglia
TZD (glitazones) MofA
sulfonylureas MofA
abruptio placentae
looks like fried eggs under histologic staining

8. Medulla
Where does the spinothalamic decussate?
Where does the dorsal column decussate?
adenomyosis
medial geniculate nucleus

9. Oligodendoglia
myelinates multiple CNS axons
thyroid cancer associtated with RET oncogene
S cells
MofA Levothyroxine

10. Von Hippel Lindau
shown to slow progression of diabetic neuropathy
beta glucocerebrosidase
hemangioblastomas of retina/cerebellum/medulla
drug that blocks purine synthesis and is metabolized by xanthine oxidase

11. PNH
cause of increased myometrial excitability
brain tumor with perivascular pseudorosettes
hemosiderinurea + thrombosis
homer wright rosettes

12. Hemolysis - elevated LFTs - Low Platelets
ovarian tumor that resembles bladder epithelium
raphe nucleus
HELLP syndrome
benzos antidote

13. Homocystienuria - Marfans
subluxation of lens
Where does the dorsal column decussate?
MPTP exposure causes depletion of what NT?
best effect of triglycerides/VLDL

14. Gauchers
blood supply for thalamus
MofA Levothyroxine
most common lysosomal storage disease
protease inhibitors MofA

15. Gastrin
solitarius nucleus
G cells
SICK PEG
anti - epithelial antibodies

16. Neutrophil chemotactic agent 'neutrophils arrive B4 others'
blocks ADP receptors to inhibit platelet aggregation
LTB4
brain tumor with foamy cells and high vascularity
oligodendrioglia

17. Decreased potency - increased Km
fusion inhibitors
may lead to multiple personalities
brenner tumor
dose response curve change with competitive antagonist

18. Hurlers
hep B seropositivity in 30% of patients
drug that blocks purine synthesis and is metabolized by xanthine oxidase
corneal clouding & MR
anti - epithelial antibodies

19. Normal or candida
gram + bacteria that requires NAD and hemin for growth
What artery causes locked in syndrome
What are the hormone changes seen in menopause
cause of low pH vaginal discharge

20. Norepinephrine
precursor to GABA
anti - mitochondrial antibodies
locus ceruleus
ovarian tumor with elevate hCG

21. Aplastic anemia - rash - agranulocytosis
cells destroyed in MS
propylthiouracil side effects
placenta previa
most common testicular tumor in infants and children up to 3 years of age

22. Gauchers
sclerosing adenosis
parietal cells
beta glucocerebrosidase
ovarian tumor that resembles bladder epithelium

23. Chocolate agar
polyhydramnios
H. flu
vasculitis a/w Hep B
which nerve lifts the eyelid?

24. Fabry's
lysosomal storage disease a/w renal disease
brain tumor with fried egg appearance
most common first line agent for septic shock
von Hippel Lindau disease

25. D cells of pancreas and gut
MofA of N- aceylcysteine
macrolides use (PUS)
what cells secrete somatostatin
what inhibits prolactin secretion

26. Inner lining of ventricles - make CSF - originate from neuroectoderm
smoking emphysema
GM2 ganglioside accumulation
ependymal cells
myelinates multiple CNS axons

27. Deficiency of aldosterone and cortisol

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28. Streptococcus
cause of low pH vaginal discharge
catalase negative
What causes coronary vasospasm as a SE?
Lewy bodies composition

29. Centriacinar
tram - track on microscope
master clock for circadian rhythms
smoking emphysema
colchicine

30. Macrophages of the CNS
most common protozoal infection in US
myelinates multiple CNS axons
microglia
anti - epithelial antibodies

31. Alpha synuclein
absent UTPGT
GM2 ganglioside accumulation
lewy body composition
SE: elevated LFTS - myositis

32. Meissner
most common breast cancer
probenecid
subluxation of lens
found in hairless skin

33. Visual (Lateral for Light)
cancer associated with Hashimoto's thyroiditis
Bisphosphonates MofA
MofA of N- aceylcysteine
Lateral geniculate nucleus

34. Actinomyces
pt has extended expiratory phase
branching rods on oral infection
erythema nodosum
glycine

35. Fibrates/statins
spike and dome on microscope
schwann cells
SE: elevated LFTS - myositis
TZD (glitazones) MofA

36. 0.6
whats the V/Q at the base of the lung
metformin side effect
pacinian
chief cells

37. Chloroquine and primaquine
kawasaki
inheritance pattern for all MENs
pseudopalisading necrosis
what meds treat malaria

38. Gauchers
alpha 1 anti - trypsin
SE: torsades de pointes
crinkled paper cytoplasm
supraoptic nucleus of hypothalamus

39. Bilateral renal agenesis or posterior urethral valves in males
GM2 ganglioside accumulation
vasculitis a/w Hep B
oligohydramnios
meissners

40. Posterior communicating - posterior cerebral - anterior choroidal arteries
thayer martin media
corneal clouding & MR
best effect on HDL
blood supply for thalamus

41. Kawasaki (treat with high dose aspirin)
sarcoma botyroides
most common protozoal infection in US
D cells
strawberry tongue

42. 2 sperm + 1 egg (fetal parts present)
hydatidiform mole with crazy high hCG
sulfonylureas
anti - mitochondrial antibodies
partial mole components

43. Papillary
thyroid cancer associtated with RET oncogene
midshaft break of humerus
currant jelly stool
hemangioblastomas of retina/cerebellum/medulla

44. Bromocriptine
pigmented iris hamartomas - neural tumors
what inhibits prolactin secretion
bocks PRPP synthetase to block purine synthesis
treatment of malignant hyperthermia

45. Dopamine
epithelial
thyroid cancer associtated with RET oncogene
chief cells
MPTP exposure causes depletion of what NT?

46. Criglar Najar
MofA of N- aceylcysteine
deficiency of mannose phosphorylation
brain tumor with psammona bodies
absent UTPGT

47. Pneumonia - URIs - STDS
macrolides use (PUS)
D cells
inheritance pattern for all MENs
vasculitis of infants and children - involving coronary arteries

48. Anti - TNF antibody - use for RA but watch out for latent TB!
honey crusted lesions common around nose/lips
infliximab
GABA - glutamine
hydrocele

49. Primary biliary cirrhosis
SE: facial flushing
vasculitis a/w Hep B
parietal cells
anti - mitochondrial antibodies

50. Damaged in multiple sclerosis
cause of malignant hyperthermia
oligodendrioglia
child with eczema - coarse facial features - cold abscesses
palisading nuclei - locally invasive