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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Flumazenil
most common lysosomal storage disease
benzos antidote
lewy body composition
3 tumors of MEN 2b

2. Niemann Pick
psammoma bodies
microglia
paraventricular nucleus of hypothalamus
sphingomyelinase deficiency

3. Chronic gout. inhibits reabsorbtion of uric acid in PCT
propylthiouracil side effects
probenecid
UMN signs
Where does the spinothalamic decussate?

4. Most common type of thyroid cancer
tumor with call - exner bodies
meissners
papillary thyroid cancer
parietal cells

5. Polyarteritis nodosa
hep B seropositivity in 30% of patients
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
granulosa cell tumor secretes what?
ovarian tumor with psammoma bodies

6. Estrogen (causes precocious puberty)
barbituates withdrawal
nucleoside reverse transcriptase inhibitors
may lead to multiple personalities
granulosa cell tumor secretes what?

7. Pemphigus vulgaris
catalase positive coagulase negative
17 alpha hydroxylase deficiency
thayer martin media
anti - epithelial antibodies

8. Benign - contains Reinke crystals - usually androgen producing
neutrophils fail to respond to chemotaxic stimuli
most common first line agent for septic shock
may lead to multiple personalities
leydig cell tumor

9. Anxiety - seizures - delirium - life threatening CV collapse
barbituates withdrawal
form multinucleated giant cells in the CNS when infected with HIV
best effect of triglycerides/VLDL
master clock for circadian rhythms

10. Cant convert testosterone to DHT - ambiguous genitalia until puberty then penis at 12
sturge weber syndrome
abruptio placentae
TZD (glitazones) MofA
5 alpha reductase deficiency

11. Trichomonas - Giardia
child with eczema - coarse facial features - cold abscesses
most common protozoal infection in US
follicular
oligodendrioglia

12. Hairless skin - dynamic fine touch
meissners
beta glucocerebrosidase
enzyme used to conjugate bilirubin
follicular

13. Hemangioblastoma
optically clear nuclei (orphan annie)
resembles an onion in cross section
brain tumor a/w von hipple - linadu syndrome
vasculitis of infants and children - involving coronary arteries

14. Serous cystadenocarcinoma
oligodendrioglia
dose response curve change with competitive antagonist
colchicine
ovarian tumor with psammoma bodies

15. Combo of inhaled anesthetics & succinylcholine
cause of malignant hyperthermia
catalase positive coagulase negative
3 tumors of MEN 1
barbituates withdrawal

16. Niacin
cause of increased myometrial excitability
brain tumor with perivascular pseudorosettes
SE: facial flushing
polyhydramnios

17. Schwann cells
brain tumor with fried egg appearance
myelinates on PNS
UMN signs
looks like fried eggs under histologic staining

18. Niacins
most common bacteria in GI tract
best effect on HDL
meissners
Abciximab

19. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
Abciximab
Conn's syndrome
brain tumor with perivascular pseudorosettes
kawasaki

20. Increased acini and intralobular fibrosis
schwann cells
What hormones share a common alpha subunit
blocks ADP receptors to inhibit platelet aggregation
sclerosing adenosis

21. ADPKD
may lead to multiple personalities
cancer associated with Hashimoto's thyroiditis
plenta accreta
mitral valve prolapse - liver diseae - berry aneurysm

22. Basilar
first line for cardiogenic shock
mitral valve prolapse - liver diseae - berry aneurysm
What artery causes locked in syndrome
defective tyrosine kinase

23. Primary biliary cirrhosis
Conn's syndrome
brain tumor with fried egg appearance
anti - mitochondrial antibodies
alpha galacosidase A

24. H. Influenza
diphtheria treatment
gram + bacteria that requires NAD and hemin for growth
iduronidase sulfatase
astrocytes

25. Bilateral renal agenesis or posterior urethral valves in males
drug that blocks purine synthesis and is metabolized by xanthine oxidase
child with partial albinism - peripherial neuropathy - recurrent infections
oligohydramnios
hemosiderinurea + thrombosis

26. Glutamate
what meds treat malaria
most common testicular tumor in infants and children up to 3 years of age
precursor to GABA
VA/VL

27. Memory
medial geniculate nucleus
looks like fried eggs under histologic staining
hippocampus
H. flu

28. Cells of BBB
D cells
astrocytes
spike and dome on microscope
brain tumor with foamy cells and high vascularity

29. HTN; masculinization
11 beta hydroxylase deficiency
iduronidase sulfatase
pigmented iris hamartomas - neural tumors
what inhibits prolactin secretion

30. Gauchers
smoking emphysema
11 beta hydroxylase deficiency
crinkled paper cytoplasm
catalase negative

31. Body sensation
cause of low pH vaginal discharge
pacinian
ventral posterior nucleus - lateral part
spike and dome on microscope

32. Trichomonas or bacterial vaginosis
cause of high pH vaginal discharge
eczema/recurrent infections/thrombocytopenia
abruptio placentae
pigmented iris hamartomas - neural tumors

33. Von Hippel Lindau
hemangioblastomas of retina/cerebellum/medulla
FGFR3 mutation
complete mole components
most common arrthymia

34. 2 sperm + 1 egg (fetal parts present)
Lewy bodies composition
partial mole components
psammoma bodies
shown to slow progression of diabetic neuropathy

35. Auditory (Medial for Music)
MofA of N- aceylcysteine
most common lysosomal storage disease
lisch nodules
medial geniculate nucleus

36. Fabry's
lysosomal storage disease a/w renal disease
3 tumors of MEN 2a
brenner tumor
optically clear nuclei (orphan annie)

37. Decreased efficacy - decreased Vmax
dorsal motor nucleus
SICK PEG
Galactocerebrosidase deficiency
dose response curve with noncompetitive antagonist

38. Sotalol - quinidine - cisapride
thayer martin media
bocks PRPP synthetase to block purine synthesis
what cells secrete somatostatin
SE: torsades de pointes

39. Ethosuximide
first line for absence seizures
11 beta hydroxylase deficiency
Where does the spinothalamic decussate?
thayer martin media

40. Intussception
alpha galacosidase A
currant jelly stool
alpha 1 anti - trypsin
basal nucleus of Meynert

41. Norepinephrine
vasculitis of infants and children - involving coronary arteries
FGFR3 mutation
contains ovarian vessels
locus ceruleus

42. Basal cell carcinoma
palisading nuclei - locally invasive
contains ovarian vessels
blocks ADP receptors to inhibit platelet aggregation
most common protozoal infection in US

43. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
melanoma tumor marker
ovarian tumor with elevate hCG
colchicine
hep B seropositivity in 30% of patients

44. Bromocriptine
first line for absence seizures
follicular
what inhibits prolactin secretion
chief cells

45. Demeclycocycline or water restriction
what nerve innervates the muscles of mastication?
PGI2 (prostacyclin))
treatment for SIADH
metformin side effect

46. Invasive ductal CA
most common breast mass in postmenopausal women
infliximab
SE: elevated LFTS - myositis
parietal cells

47. Granulosa cell tumor
What causes coronary vasospasm as a SE?
protease inhibitors MofA
pigmented iris hamartomas - neural tumors
tumor with call - exner bodies

48. Deficiency of aldosterone and cortisol

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49. Protamine sulfate
heparin antidote
placenta previa
brenner tumor
opioids antidote

50. Clopidogrel - ticoplidine
blocks ADP receptors to inhibit platelet aggregation
What thyroid pathology has an extremely tender thyroid gland
astrocytes
defective tyrosine kinase