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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Inner lining of ventricles - make CSF - originate from neuroectoderm
nucleoside reverse transcriptase inhibitors
what meds treat malaria
copper - arsenic - gold antidote
ependymal cells

2. Demeclycocycline or water restriction
follicular
antibiotic with SE of eosinophilia
D cells
treatment for SIADH

3. Fibrates
most common primary cardiac tumor in kiddos
thymidylate synthase
abruptio placentae
best effect of triglycerides/VLDL

4. Complete
hydatidiform mole with crazy high hCG
vasculitis of infants and children - involving coronary arteries
UMN signs
PGI2 (prostacyclin))

5. Cavernous hemangiomas in skin - mucosa & organs; autosomal dominant - a/w renal CA - hemangioblastoma in retina - brainstem & cerebellum
BCG PQRS
most common breast tumor in women under 25
thymidylate synthase
von Hippel Lindau disease

6. Papillary
cause of increased myometrial excitability
precursor to GABA
thyroid cancer associtated with RET oncogene
cause of malignant hyperthermia

7. Attachment of placenta to lower uterine segment
best effect of triglycerides/VLDL
fusion inhibitors
placenta previa
meissners

8. Bind viral gp41 subunit
fusion inhibitors
whats the V/Q at the base of the lung
deficiency of mannose phosphorylation
What are the hormone changes seen in menopause

9. Pneumonia - URIs - STDS
alpha galacosidase A
child with partial albinism - peripherial neuropathy - recurrent infections
most common primary cardiac tumor in kiddos
macrolides use (PUS)

10. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
Shigella
LTB4
hippocampus
psammoma bodies

11. Hemolysis - elevated LFTs - Low Platelets
Addison's
kawasaki
HELLP syndrome
most common arrthymia

12. A/w esophageal/duodenal atresia and anencephaly
spike and dome on microscope
leydig cell tumor
polyhydramnios
3 tumors of MEN 2a

13. Incomplete fusion of processus vaginalis
benzos antidote
first line for cardiogenic shock
hydrocele
dermatin sulfate accumulation

14. Chocolate agar
LT C4 D4 E4
H. flu
sulfonylureas MofA
locus ceruleus

15. Estrogen (causes precocious puberty)
3 tumors of MEN 1
spike and dome on microscope
granulosa cell tumor secretes what?
looks like fried eggs under histologic staining

16. Weakness - atrophy - fasiculations - decreased reflexes & tone
rate limiting step in carb digestion
ventral posterior nucleus - medial part
HELLP syndrome
LMN signs

17. Cocain and sumatriptan
Schiller Duval bodies
whats the V/Q at the apex of the lung
What artery causes locked in syndrome
What causes coronary vasospasm as a SE?

18. Gauchers
beta glucocerebrosidase
failure of endodermal development
opioids antidote
order of nerve blockade

19. Atrial fibrillation
blocks ADP receptors to inhibit platelet aggregation
most common arrthymia
catalase positive coagulase negative
defective tyrosine kinase

20. Decreased FEV/FVC ratio
locus ceruleus
corneal clouding & MR
hallmark sign of COPD
probenecid

21. Negri bodies
rabies
supraoptic nucleus of hypothalamus
placenta previa
inheritance pattern for all MENs

22. Choriocarcinoma
papillary thyroid cancer
21 hydroxylase deficiency
tumor composed of cytotrophoblasts and syncytiotrophoblasts
first line for absence seizures

23. Chronic gout. inhibits reabsorbtion of uric acid in PCT
optically clear nuclei (orphan annie)
probenecid
solitarius nucleus
hemangioblastomas of retina/cerebellum/medulla

24. HTN; XY will be a girl - XX will lack secondary sex char.
What causes coronary vasospasm as a SE?
17 alpha hydroxylase deficiency
first line for absence seizures
mitral valve prolapse - liver diseae - berry aneurysm

25. Hurlers
bocks PRPP synthetase to block purine synthesis
alpha L iduronidase
cells destroyed in Guillain Barre
hemosiderinurea + thrombosis

26. Wiscott - Aldrich
branching rods on oral infection
ependymal cells
hep B seropositivity in 30% of patients
eczema/recurrent infections/thrombocytopenia

27. Hemangioblastoma
alpha L iduronidase
brain tumor with foamy cells and high vascularity
complete mole components
eczema/recurrent infections/thrombocytopenia

28. Macrolides
S cells
antibiotic with SE of eosinophilia
honey crusted lesions common around nose/lips
ovarian tumor with elevate hCG

29. Prevents incorporation into host DNA
abruptio placentae
macrolides use (PUS)
Where does the spinothalamic decussate?
nucleoside reverse transcriptase inhibitors

30. Ach
hemosiderinurea + thrombosis
most common testicular tumor in infants and children up to 3 years of age
basal nucleus of Meynert
cause of high pH vaginal discharge

31. Small diameter > large diameter; myelinated > unmyelinated
brenner tumor
gram + bacteria that requires NAD and hemin for growth
order of nerve blockade
hippocampus

32. Estrogen
drug that blocks purine synthesis and is metabolized by xanthine oxidase
cause of LH surge
locus ceruleus
cells destroyed in MS

33. Vibration - pressure
best effect of triglycerides/VLDL
pacinian
most common first line agent for septic shock
pigmented iris hamartomas - neural tumors

34. Flumazenil
D cells
benzos antidote
chief cells
polyhydramnios

35. Endometrial glands inside myometrium
adenomyosis
sulfonylureas
HELLP syndrome
LTB4

36. Bilateral renal agenesis or posterior urethral valves in males
what inhibits prolactin secretion
lisch nodules
oligohydramnios
supraoptic nucleus of hypothalamus

37. Ethosuximide
Conn's syndrome
FGFR3 mutation
dorsal motor nucleus
first line for absence seizures

38. Schwann cells
Yolk sac tumor produces...
myelinates on PNS
ovarian tumor with psammoma bodies
ovarian tumor that resembles bladder epithelium

39. Gilberts
most common testicular tumor
mildly decreased UDPGT
kluver bucy
beta glucocerebrosidase

40. Tay SaX
most common breast mass in pre - menopausal women
SICK PEG
heXosaminidase
cancer associated with Hashimoto's thyroiditis

41. Basal cell carcinoma
most common first line agent for septic shock
palisading nuclei - locally invasive
21 hydroxylase deficiency
blood supply for thalamus

42. Dopamine
MPTP exposure causes depletion of what NT?
BCG PQRS
What oncogene is a/w MEN 2a/b
parietal cells

43. NE
brain tumor with foamy cells and high vascularity
most common first line agent for septic shock
thymidylate synthase
crinkled paper cytoplasm

44. Serous cystadenocarcinoma
ovarian tumor with psammoma bodies
most common protozoal infection in US
microglia
glycine

45. Hurlers
parietal cells
raphe nucleus
What causes coronary vasospasm as a SE?
corneal clouding & MR

46. ACE inhibitors
melanoma tumor marker
precursor to GABA
copper - arsenic - gold antidote
shown to slow progression of diabetic neuropathy

47. Radial nerve - deep brachial artery
3 tumors of MEN 2a
midshaft break of humerus
locus ceruleus
first line for absence seizures

48. Motor
dose response curve change with competitive antagonist
sturge weber syndrome
VA/VL
sulfonylureas

49. Macconkey's agar
Shigella
colchicine
branching rods on oral infection
locus ceruleus

50. Sotalol - quinidine - cisapride
honey crusted lesions common around nose/lips
SE: torsades de pointes
most common breast mass in pre - menopausal women
ovarian tumor with psammoma bodies