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USMLE Pathophys

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Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Penicillamine
5 alpha reductase deficiency
enzyme used to conjugate bilirubin
copper - arsenic - gold antidote
keratin filled cysts

2. Makes oxytocin
paraventricular nucleus of hypothalamus
antibiotic with SE of eosinophilia
cough - conjunctivitis - coryza - fever
contains ovarian vessels

3. Invasive ductal
cause of LH surge
follicular
most common breast cancer
Where does the dorsal column decussate?

4. S-100
UMN signs
increased MCHC and hemolytic anemia
melanoma tumor marker
Where does the spinothalamic decussate?

5. Antitoxin - penicillin - DPT vaccine
sulfonylureas side effect
tram - track on microscope
glycine
diphtheria treatment

6. Fibrates
best effect of triglycerides/VLDL
what meds treat malaria
melanoma tumor marker
ovarian tumor that resembles bladder epithelium

7. Trigeminal
what nerve innervates the muscles of mastication?
anti - epithelial antibodies
3 tumors of MEN 1
lysosomal storage disease a/w renal disease

8. Decreased FEV/FVC ratio
sclerosing adenosis
hallmark sign of COPD
cause of increased myometrial excitability
GM2 ganglioside accumulation

9. HTN - proteinuria - edema
preeclampsia
anti - epithelial antibodies
kawasaki
vasculitis a/w Hep B

10. Sotalol - quinidine - cisapride
SE: torsades de pointes
von Hippel Lindau disease
lisch nodules
anti - epithelial antibodies

11. Niacin
blood supply for thalamus
SE: facial flushing
21 hydroxylase deficiency
child with eczema - coarse facial features - cold abscesses

12. Babinski - weakness - increased reflexes & tone - spastic paralysis
UMN signs
etanercept
Addison's
sumatriptan

13. Basilar
most common breast mass in postmenopausal women
Shigella
Where does the dorsal column decussate?
What artery causes locked in syndrome

14. Normal or candida
inheritance pattern for all MENs
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
intranuclear inclusions seen in herpes simplex encephalitis
cause of low pH vaginal discharge

15. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
etanercept
parietal cells
colchicine
LT C4 D4 E4

16. Oligosaccaride hydrolase
precursor to GABA
alpha galacosidase A
cause of low pH vaginal discharge
rate limiting step in carb digestion

17. Ach
3 tumors of MEN 1
basal nucleus of Meynert
most common testicular tumor
most common breast mass in postmenopausal women

18. Fibroadenoma
plenta accreta
11 beta hydroxylase deficiency
most common breast tumor in women under 25
I cells

19. Masculinization - hypovolemic shock
von Hippel Lindau disease
TZD (glitazones) MofA
absent UTPGT
21 hydroxylase deficiency

20. Combo of inhaled anesthetics & succinylcholine
child with partial albinism - peripherial neuropathy - recurrent infections
myelinates multiple CNS axons
first line for absence seizures
cause of malignant hyperthermia

21. Somatostatin
increased MCHC and hemolytic anemia
master clock for circadian rhythms
D cells
strawberry tongue

22. 5- fluorouracil
what checkpoint is p53 involved with?
thymidylate synthase
LMN signs
Galactocerebrosidase deficiency

23. DiGeorge
failure of endodermal development
What artery causes locked in syndrome
honey crusted lesions common around nose/lips
midshaft break of humerus

24. TNF receptor
rabies
etanercept
hydrocele
contains ovarian vessels

25. Autosomal dominant
precursor to GABA
currant jelly stool
P450 Inhibitors
inheritance pattern for all MENs

26. Serous cystadenocarcinoma
SE: facial flushing
SE: torsades de pointes
P450 Inhibitors
ovarian tumor with psammoma bodies

27. Brenners tumor
iduronidase sulfatase
What hormones share a common alpha subunit
grossly black liver
ovarian tumor that resembles bladder epithelium

28. 2 sperm + empty egg (no fetal parts)
medial geniculate nucleus
complete mole components
follicular
myelinates multiple CNS axons

29. Fabrys
alpha galacosidase A
thromboxane A2
kawasaki
P450 inducers

30. Neurofibromatosis
mildly decreased UDPGT
sturge weber syndrome
smoking emphysema
lisch nodules

31. Wiscott - Aldrich
dose response curve with noncompetitive antagonist
abruptio placentae
form multinucleated giant cells in the CNS when infected with HIV
eczema/recurrent infections/thrombocytopenia

32. Von Hippel Lindau
pacinian
MPTP exposure causes depletion of what NT?
strawberry tongue
hemangioblastomas of retina/cerebellum/medulla

33. Estrogen
bocks PRPP synthetase to block purine synthesis
anti - platelet antibodies
cause of increased myometrial excitability
P450 Inhibitors

34. Obstructive - COPD
cells destroyed in MS
FGFR3 mutation
dorsal motor nucleus
pt has extended expiratory phase

35. Demeclycocycline or water restriction
MPTP exposure causes depletion of what NT?
LTB4
treatment for SIADH
first line for absence seizures

36. Cowdry type A inclusions
most common bacteria in GI tract
intranuclear inclusions seen in herpes simplex encephalitis
pseudopalisading necrosis
cause of LH surge

37. Inflammatory lesions of subq fat - usually on anterior shins. a/w infections
heparin antidote
psammoma bodies
erythema nodosum
cause of low pH vaginal discharge

38. Microglia
sturge weber syndrome
form multinucleated giant cells in the CNS when infected with HIV
optically clear nuclei (orphan annie)
epithelial

39. H. Influenza
locus ceruleus
21 hydroxylase deficiency
gram + bacteria that requires NAD and hemin for growth
cancer associated with Hashimoto's thyroiditis

40. Hairless skin - dynamic fine touch
cells destroyed in Guillain Barre
basal nucleus of Meynert
meissners
catalase positive coagulase negative

41. Staph epidermidis - staph sapro
catalase positive coagulase negative
honey crusted lesions common around nose/lips
alpha 1 anti - trypsin
lysosomal storage disease a/w renal disease

42. PNH
pigmented iris hamartomas - neural tumors
what inhibits prolactin secretion
antibiotic with SE of eosinophilia
hemosiderinurea + thrombosis

43. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
defective tyrosine kinase
what cells secrete somatostatin
drug induced lupus
hydrocele

44. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
whats the V/Q at the base of the lung
cancer associated with Hashimoto's thyroiditis
SICK PEG
silver stain of gram negative rods

45. Seborric keratosis
5 alpha reductase deficiency
first line for absence seizures
blood supply for thalamus
keratin filled cysts

46. Visceral sensory
shown to slow progression of diabetic neuropathy
corneal clouding & MR
first line for absence seizures
solitarius nucleus

47. Pemphigus vulgaris
brain tumor with foamy cells and high vascularity
absent UTPGT
P450 inducers
anti - epithelial antibodies

48. Medullary
Shigella
beta glucocerebrosidase
partial mole components
cancer arising from parafollicular C cells

49. Bromocriptine
ventral posterior nucleus - lateral part
treatment of malignant hyperthermia
brain tumor with foamy cells and high vascularity
what inhibits prolactin secretion

50. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
TZD (glitazones) MofA
cancer arising from parafollicular C cells
vasculitis of infants and children - involving coronary arteries
sclerosing adenosis

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USMLE Pathophys

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