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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Atrial fibrillation
most common arrthymia
epithelial
kawasaki
glycine

2. Estrogen (causes precocious puberty)
granulosa cell tumor secretes what?
smoking emphysema
Where does the lateral corticospinal decussate?
ventral posterior nucleus - medial part

3. Cocain and sumatriptan
most common lysosomal storage disease
opioids antidote
What causes coronary vasospasm as a SE?
3 tumors of MEN 1

4. Endometrial glands inside myometrium
adenomyosis
Shigella
most common first line agent for septic shock
opioids antidote

5. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
opioid withdrawal
t - PA - streptokinase antidote
found in hairless skin
glycine

6. Fibrates
antibody against philadelphia chromosome
GFAP positive
SE: facial flushing
best effect of triglycerides/VLDL

7. 6- mecaptopurine (metabolized by xanthine oxidase)
neutrophils fail to respond to chemotaxic stimuli
ovarian tumor with psammoma bodies
bocks PRPP synthetase to block purine synthesis
probenecid

8. Bind viral gp41 subunit
pt has extended expiratory phase
fusion inhibitors
D cells
spike and dome on microscope

9. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
hydatidiform mole with crazy high hCG
colchicine
brain tumor with perivascular pseudorosettes
branching rods on oral infection

10. Protamine sulfate
heparin antidote
currant jelly stool
tumor composed of cytotrophoblasts and syncytiotrophoblasts
Conn's syndrome

11. Port wine stains - ipsilateral leptomeningeal angioma; can cause glaucoma - seizures - hemipareis - and MR
sturge weber syndrome
cause of high pH vaginal discharge
cough - conjunctivitis - coryza - fever
myelinates multiple CNS axons

12. Fibrates/statins
most common lysosomal storage disease
palisading nuclei - locally invasive
hemosiderinurea + thrombosis
SE: elevated LFTS - myositis

13. Endometrial CA
most common gyno malignancy
kluver bucy
dose response curve with noncompetitive antagonist
whats the V/Q at the apex of the lung

14. Dantrolene (prevents release of calcium from SR of muscle)
alpha galacosidase A
hemosiderinurea and thrombosis
treatment of malignant hyperthermia
SE: elevated LFTS - myositis

15. Ovarian bengin tumor...looks like bladder
brenner tumor
antibiotic with SE of eosinophilia
cause of malignant hyperthermia
first line for absence seizures

16. Basilar
heparin antidote
What artery causes locked in syndrome
lewy body composition
copper - arsenic - gold antidote

17. Gauchers
probenecid
BCG PQRS
beta glucocerebrosidase
thayer martin media

18. Dopamine
palisading nuclei - locally invasive
master clock for circadian rhythms
VA/VL
MPTP exposure causes depletion of what NT?

19. Gauchers
thymidylate synthase
keratin filled cysts
Where does the lateral corticospinal decussate?
crinkled paper cytoplasm

20. Fibrocystic
most common breast mass in pre - menopausal women
hep B seropositivity in 30% of patients
astrocytes
placenta previa

21. Weakness - atrophy - fasiculations - decreased reflexes & tone
What hormones share a common alpha subunit
LMN signs
first line for cardiogenic shock
cough - conjunctivitis - coryza - fever

22. G1/S & G2/M
hallmark sign of COPD
P450 Inhibitors
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
what checkpoint is p53 involved with?

23. Masculinization - hypovolemic shock
oligodendrioglia
21 hydroxylase deficiency
brain tumor with psammona bodies
x- linked recessive lysosomal storage diseases

24. Oculomotor
thayer martin media
defective tyrosine kinase
which nerve lifts the eyelid?
absent UTPGT

25. Trichomonas or bacterial vaginosis
whats the V/Q at the base of the lung
sulfonylureas
cause of high pH vaginal discharge
raphe nucleus

26. Microglia
smoking emphysema
lysosomal storage disease - demyelinating disease
optically clear nuclei (orphan annie)
form multinucleated giant cells in the CNS when infected with HIV

27. Inner lining of ventricles - make CSF - originate from neuroectoderm
honey crusted lesions common around nose/lips
whats the V/Q at the base of the lung
increased MCHC and hemolytic anemia
ependymal cells

28. HTN; XY will be a girl - XX will lack secondary sex char.
locus ceruleus
thayer martin media
17 alpha hydroxylase deficiency
glycine

29. Placenta attached to myometrium
plenta accreta
what inhibits prolactin secretion
Lateral geniculate nucleus
LMN signs

30. Wiscott - Aldrich
What thyroid pathology has an extremely tender thyroid gland
Galactocerebrosidase deficiency
eczema/recurrent infections/thrombocytopenia
erythema nodosum

31. Alpha feto protein
Abciximab
brain tumor with perivascular pseudorosettes
Yolk sac tumor produces...
antibiotic with SE of eosinophilia

32. Job's or LAD
most common primary cardiac tumor in kiddos
LTB4
neutrophils fail to respond to chemotaxic stimuli
preeclampsia

33. Yolk sac
strawberry tongue
most common testicular tumor in infants and children up to 3 years of age
P450 Inhibitors
most common bacteria in GI tract

34. Babinski - weakness - increased reflexes & tone - spastic paralysis
metformin side effect
alpha L iduronidase
intranuclear inclusions seen in herpes simplex encephalitis
UMN signs

35. Motor innervation of pharynx - larynx and upper esophagus
cells destroyed in Guillain Barre
ambiguous nucleus
most common bacteria in GI tract
locus ceruleus

36. Ach
most common protozoal infection in US
Aschoff bodies
basal nucleus of Meynert
What hormones share a common alpha subunit

37. Choriocarcinoma
what cells secrete somatostatin
Galactocerebrosidase deficiency
tumor composed of cytotrophoblasts and syncytiotrophoblasts
barbituates withdrawal

38. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
astrocytes
hallmark sign of COPD
which nerve lifts the eyelid?
defective tyrosine kinase

39. Somatostatin
D cells
What are the hormone changes seen in menopause
most common testicular tumor
21 hydroxylase deficiency

40. Chediak - Higashi
child with partial albinism - peripherial neuropathy - recurrent infections
3 tumors of MEN 1
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
cause of high pH vaginal discharge

41. Meningioma
brain tumor with psammona bodies
benzos antidote
rabies
brenner tumor

42. Suspensory ligament of ovaries
contains ovarian vessels
Schiller Duval bodies
GFAP positive
paraventricular nucleus of hypothalamus

43. ADPKD
alpha L iduronidase
adenomyosis
palisading nuclei - locally invasive
mitral valve prolapse - liver diseae - berry aneurysm

44. Estrogen
antibiotic with SE of eosinophilia
myelinates multiple CNS axons
cause of increased myometrial excitability
most common lysosomal storage disease

45. Hypoglycemia
G cells
sulfonylureas side effect
Shigella
sulfonylureas MofA

46. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
Lewy bodies composition
optically clear nuclei (orphan annie)
PGI2 (prostacyclin))
What artery causes locked in syndrome

47. NE
locus ceruleus
hep B seropositivity in 30% of patients
best effect on HDL
chief cells

48. Visual (Lateral for Light)
Lateral geniculate nucleus
mitral valve prolapse - liver diseae - berry aneurysm
plenta accreta
Where does the spinothalamic decussate?

49. Makes ADH
HELLP syndrome
supraoptic nucleus of hypothalamus
blocks ADP receptors to inhibit platelet aggregation
whats the V/Q at the apex of the lung

50. Cavernous hemangiomas in skin - mucosa & organs; autosomal dominant - a/w renal CA - hemangioblastoma in retina - brainstem & cerebellum
von Hippel Lindau disease
TZD (glitazones) MofA
blocks ADP receptors to inhibit platelet aggregation
PTU