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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Microglia
solitarius nucleus
strawberry tongue
t - PA - streptokinase antidote
form multinucleated giant cells in the CNS when infected with HIV

2. Medulla
Where does the dorsal column decussate?
testicular tumor that can present with gynecomastia
oligodendrioglia
shown to slow progression of diabetic neuropathy

3. Bromocriptine
I cells
H. flu
what inhibits prolactin secretion
brain tumor with perivascular pseudorosettes

4. Medullary thyroid - pheochromocytoma - parathryoid
brain tumor with foamy cells and high vascularity
barbituates withdrawal
ependymal cells
3 tumors of MEN 2a

5. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
LT C4 D4 E4
sulfonylureas
most common breast mass in pre - menopausal women
most common first line agent for septic shock

6. Closes K+ channel on B cells causing depolarization and thus calcium influx which causes insulin release
contains ovarian vessels
optically clear nuclei (orphan annie)
papillary thyroid cancer
sulfonylureas MofA

7. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
cause of high pH vaginal discharge
epithelial
pseudopalisading necrosis
SICK PEG

8. Kawasaki
hippocampus
BCG PQRS
Shigella
vasculitis of infants and children - involving coronary arteries

9. BCG PQRS
most common gyno malignancy
von Hippel Lindau disease
P450 inducers
HELLP syndrome

10. Actinomyces
catalase positive coagulase negative
locus ceruleus
microglia
branching rods on oral infection

11. Ovarian bengin tumor...looks like bladder
SE: elevated LFTS - myositis
brenner tumor
Addison's
most common testicular tumor in infants and children up to 3 years of age

12. Sulfonamides - hydralazine - isonazid - procainamide - phenytoin
Yolk sac tumor produces...
what meds treat malaria
Addison's
drug induced lupus

13. Lactic acidosis
What hormones share a common alpha subunit
MofA of N- aceylcysteine
lisch nodules
metformin side effect

14. Papillary CA of thyroid - meningioma - mesothelioma - serous cystadenocarcinoma of ovary
hep B seropositivity in 30% of patients
psammoma bodies
thyroid cancer associtated with RET oncogene
cause of increased myometrial excitability

15. Decreased FEV/FVC ratio
Conn's syndrome
basal nucleus of Meynert
hallmark sign of COPD
thyroid cancer associtated with RET oncogene

16. Gilberts
oligodendrioglia
abruptio placentae
mildly decreased UDPGT
What oncogene is a/w MEN 2a/b

17. Decreased efficacy - decreased Vmax
dose response curve with noncompetitive antagonist
propylthiouracil side effects
low dose ASA effects - intermediate dose - high dose
beta glucocerebrosidase

18. NE
lead antidote
probenecid
honey crusted lesions common around nose/lips
most common first line agent for septic shock

19. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
BCG PQRS
keratin filled cysts
hydatidiform mole with crazy high hCG
TZD (glitazones) MofA

20. Fabry's
lysosomal storage disease a/w renal disease
tumor composed of cytotrophoblasts and syncytiotrophoblasts
astrocytes
optically clear nuclei (orphan annie)

21. Deficiency of aldosterone and cortisol

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22. Niacin
LMN signs
crinkled paper cytoplasm
Lateral geniculate nucleus
SE: facial flushing

23. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
anti - epithelial antibodies
kawasaki
medial geniculate nucleus
cancer arising from parafollicular C cells

24. Atrial fibrillation
most common arrthymia
whats the V/Q at the base of the lung
infliximab
meissners

25. Glucuronyl transferase
enzyme used to conjugate bilirubin
schwann cells
lisch nodules
etanercept

26. Fibrates/statins
SE: elevated LFTS - myositis
hemangioblastomas of retina/cerebellum/medulla
ependymal cells
pacinian

27. Kawasaki (treat with high dose aspirin)
lysosomal storage disease a/w renal disease
strawberry tongue
tumor with call - exner bodies
vasculitis of infants and children - involving coronary arteries

28. Regenerates glutathione
paraventricular nucleus of hypothalamus
ovarian tumor that resembles bladder epithelium
nucleoside reverse transcriptase inhibitors
MofA of N- aceylcysteine

29. Hemangioblastoma
raphe nucleus
mitral valve prolapse - liver diseae - berry aneurysm
MofA of N- aceylcysteine
brain tumor with foamy cells and high vascularity

30. Alpha synuclein
sumatriptan
keratin filled cysts
low dose ASA effects - intermediate dose - high dose
lewy body composition

31. TNF receptor
subluxation of lens
cells destroyed in MS
rate limiting step in carb digestion
etanercept

32. Invasive ductal CA
bocks PRPP synthetase to block purine synthesis
most common breast mass in postmenopausal women
pt has extended expiratory phase
metformin side effect

33. Hurlers
alpha L iduronidase
treatment of malignant hyperthermia
ovarian tumor with elevate hCG
hemosiderinurea and thrombosis

34. Marfans
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
propylthiouracil side effects
hippocampus
branching rods on oral infection

35. Pacinian
plenta accreta
resembles an onion in cross section
MofA Levothyroxine
kluver bucy

36. Medullary thyroid - pheochromocytoma - oral/intestinal ganglionueromatosis
3 tumors of MEN 2b
GM2 ganglioside accumulation
spike and dome on microscope
pacinian

37. Cell type involved in most ovarian tumors
alpha 1 anti - trypsin
epithelial
brain tumor with perivascular pseudorosettes
branching rods on oral infection

38. Bind viral gp41 subunit
what nerve innervates the muscles of mastication?
fusion inhibitors
cells destroyed in MS
basal nucleus of Meynert

39. Chediak - Higashi
child with partial albinism - peripherial neuropathy - recurrent infections
cause of low pH vaginal discharge
cancer associated with Hashimoto's thyroiditis
brain tumor with psammona bodies

40. Causes vasoconstriction (use for acute migraines)
sumatriptan
form multinucleated giant cells in the CNS when infected with HIV
most common testicular tumor in infants and children up to 3 years of age
alpha galacosidase A

41. Serous cystadenocarcinoma
ovarian tumor with psammoma bodies
found in hairless skin
Yolk sac tumor produces...
treatment of malignant hyperthermia

42. A few levels above the level of entry
ventral posterior nucleus - lateral part
bocks PRPP synthetase to block purine synthesis
Where does the spinothalamic decussate?
cancer arising from parafollicular C cells

43. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
astrocytes
absent UTPGT
Yolk sac tumor produces...
homer wright rosettes

44. Increases platelet aggregation and vasoconstriction
myelinates multiple CNS axons
Yolk sac tumor produces...
Where does the lateral corticospinal decussate?
thromboxane A2

45. Staph epidermidis - staph sapro
antibiotic with SE of eosinophilia
catalase positive coagulase negative
What causes coronary vasospasm as a SE?
most common breast tumor in women under 25

46. Serotonin
most common breast mass in pre - menopausal women
intranuclear inclusions seen in herpes simplex encephalitis
raphe nucleus
cause of high pH vaginal discharge

47. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
benzos antidote
keratin filled cysts
P450 Inhibitors
sarcoma botyroides

48. Estrogen (causes precocious puberty)
S cells
granulosa cell tumor secretes what?
GABA - glutamine
increased MCHC and hemolytic anemia

49. Tay Sachs
GM2 ganglioside accumulation
polyhydramnios
propylthiouracil side effects
mitral valve prolapse - liver diseae - berry aneurysm

50. Increased acini and intralobular fibrosis
dorsal motor nucleus
most common breast mass in pre - menopausal women
sclerosing adenosis
UMN signs