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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Choriocarcinoma or dysgerminoma
17 alpha hydroxylase deficiency
ovarian tumor with elevate hCG
sclerosing adenosis
opioid withdrawal

2. Chloroquine and primaquine
SE: torsades de pointes
what meds treat malaria
failure of endodermal development
found in hairless skin

3. Damaged in multiple sclerosis
oligodendrioglia
What artery causes locked in syndrome
most common testicular tumor in infants and children up to 3 years of age
most common breast tumor in women under 25

4. SICK PEG
P450 Inhibitors
dose response curve with noncompetitive antagonist
whats the V/Q at the base of the lung
cancer associated with Hashimoto's thyroiditis

5. Motor innervation of pharynx - larynx and upper esophagus
LTB4
SE: elevated LFTS - myositis
ambiguous nucleus
most common breast cancer

6. Yolk sac tumor
most common primary cardiac tumor in kiddos
supraoptic nucleus of hypothalamus
protease inhibitors MofA
Schiller Duval bodies

7. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
hallmark sign of COPD
opioid withdrawal
most common breast mass in postmenopausal women
Schiller Duval bodies

8. Dantrolene (prevents release of calcium from SR of muscle)
treatment of malignant hyperthermia
whats the V/Q at the apex of the lung
GM2 ganglioside accumulation
3 tumors of MEN 2a

9. Bruton's agammaglobulinemia
sulfonylureas
defective tyrosine kinase
ambiguous nucleus
ventral posterior nucleus - lateral part

10. Ach
increased MCHC and hemolytic anemia
sturge weber syndrome
ovarian tumor that resembles bladder epithelium
basal nucleus of Meynert

11. Invasive ductal
TZD (glitazones) MofA
most common gyno malignancy
most common breast cancer
treatment for SIADH

12. Fabry's & Hunters
Abciximab
branching rods on oral infection
x- linked recessive lysosomal storage diseases
most common breast tumor in women under 25

13. CCK
Bisphosphonates MofA
What thyroid pathology has an extremely tender thyroid gland
branching rods on oral infection
I cells

14. 2 sperm + empty egg (no fetal parts)
lewy body composition
leydig cell tumor
schwann cells
complete mole components

15. Regenerates glutathione
honey crusted lesions common around nose/lips
MofA of N- aceylcysteine
sturge weber syndrome
21 hydroxylase deficiency

16. Measles
cough - conjunctivitis - coryza - fever
basal nucleus of Meynert
x- linked recessive lysosomal storage diseases
11 beta hydroxylase deficiency

17. Fabrys
brain tumor with perivascular pseudorosettes
alpha galacosidase A
child with eczema - coarse facial features - cold abscesses
first line for absence seizures

18. Homocystienuria - Marfans
treatment for SIADH
most common testicular tumor in infants and children up to 3 years of age
palisading nuclei - locally invasive
subluxation of lens

19. Fabry's
subluxation of lens
metformin side effect
chief cells
lysosomal storage disease a/w renal disease

20. Tay Sachs
pt has extended expiratory phase
sturge weber syndrome
GM2 ganglioside accumulation
leydig cell tumor

21. Oligodendrioma
paraventricular nucleus of hypothalamus
order of nerve blockade
brain tumor with fried egg appearance
enzyme used to conjugate bilirubin

22. Neurofibromatosis
lisch nodules
ependymal cells
best effect on HDL
myelinates on PNS

23. Inhibitory in the brain - stimulatory in the brain
GABA - glutamine
sulfonylureas MofA
What are the hormone changes seen in menopause
what cells secrete somatostatin

24. Wiscott - Aldrich
rate limiting step in carb digestion
locus ceruleus
eczema/recurrent infections/thrombocytopenia
whats the V/Q at the base of the lung

25. Dissociative
lysosomal storage disease - demyelinating disease
may lead to multiple personalities
what checkpoint is p53 involved with?
anti - mitochondrial antibodies

26. Mucocutaneous lymph node syndrome - necrotizing vasculitis - coronary aneurysms - strawberry tongue
kawasaki
3 tumors of MEN 2b
BCG PQRS
myelinates on PNS

27. Tay SaX
MofA of N- aceylcysteine
heXosaminidase
Where does the dorsal column decussate?
ventral posterior nucleus - lateral part

28. Support - repair - potassium metabolism - remove excess NT - maintain BBB - marker is GFAP
sclerosing adenosis
what cells secrete somatostatin
astrocytes
follicular

29. Dopamine
MPTP exposure causes depletion of what NT?
follicular
H. flu
What oncogene is a/w MEN 2a/b

30. Serous cystadenocarcinoma
may lead to multiple personalities
pt has extended expiratory phase
ovarian tumor with psammoma bodies
Abciximab

31. H. Influenza
treatment of malignant hyperthermia
most common arrthymia
gram + bacteria that requires NAD and hemin for growth
sphingomyelinase deficiency

32. Endometrial CA
found in hairless skin
t - PA - streptokinase antidote
most common gyno malignancy
Yolk sac tumor produces...

33. Normal or candida
propylthiouracil side effects
cause of low pH vaginal discharge
mildly decreased UDPGT
tumor composed of cytotrophoblasts and syncytiotrophoblasts

34. Cells of BBB
may lead to multiple personalities
astrocytes
papillary thyroid cancer
GM2 ganglioside accumulation

35. Sotalol - quinidine - cisapride
treatment for SIADH
dose response curve with noncompetitive antagonist
SE: torsades de pointes
midshaft break of humerus

36. Panacinar
lysosomal storage disease - demyelinating disease
GFAP positive
alpha 1 anti - trypsin
mildly decreased UDPGT

37. Gonorrhea
thayer martin media
anti - epithelial antibodies
catalase negative
UMN signs

38. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
most common breast mass in postmenopausal women
What are the hormone changes seen in menopause
UMN signs
SICK PEG

39. Thryroxine replacement
treatment for SIADH
MofA Levothyroxine
fusion inhibitors
absent UTPGT

40. Medulla
supraoptic nucleus of hypothalamus
corneal clouding & MR
Where does the dorsal column decussate?
raphe nucleus

41. Chediak - Higashi
child with partial albinism - peripherial neuropathy - recurrent infections
looks like fried eggs under histologic staining
oligodendrioglia
sturge weber syndrome

42. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
colchicine
subluxation of lens
ambiguous nucleus
bocks PRPP synthetase to block purine synthesis

43. Antitoxin - penicillin - DPT vaccine
hippocampus
branching rods on oral infection
diphtheria treatment
BCG PQRS

44. Bilateral renal agenesis or posterior urethral valves in males
drug induced lupus
oligohydramnios
P450 inducers
catalase negative

45. Combo of inhaled anesthetics & succinylcholine
honey crusted lesions common around nose/lips
sumatriptan
cause of malignant hyperthermia
kluver bucy

46. Huntingtons chorea
vasculitis of infants and children - involving coronary arteries
Bisphosphonates MofA
chromosome 4
preeclampsia

47. Anti - TNF antibody - use for RA but watch out for latent TB!
brain tumor with psammona bodies
S cells
infliximab
cancer associated with Hashimoto's thyroiditis

48. Invasive ductal CA
H. flu
MPTP exposure causes depletion of what NT?
most common breast mass in postmenopausal women
what cells secrete somatostatin

49. 5- fluorouracil
thymidylate synthase
What artery causes locked in syndrome
astrocytes
hallmark sign of COPD

50. Achondroplasia
iduronidase sulfatase
what cells secrete somatostatin
best effect of triglycerides/VLDL
FGFR3 mutation