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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Chediak - Higashi
tumor with call - exner bodies
child with partial albinism - peripherial neuropathy - recurrent infections
Conn's syndrome
UMN signs

2. ACE inhibitors
LMN signs
sulfonylureas MofA
shown to slow progression of diabetic neuropathy
copper - arsenic - gold antidote

3. Autosomal dominant
resembles an onion in cross section
inheritance pattern for all MENs
adenomyosis
may lead to multiple personalities

4. Meningioma
Conn's syndrome
brain tumor with psammona bodies
anti - platelet antibodies
most common breast cancer

5. 5- fluorouracil
antibody against philadelphia chromosome
MPTP exposure causes depletion of what NT?
thymidylate synthase
thyroid cancer associtated with RET oncogene

6. Microglia
form multinucleated giant cells in the CNS when infected with HIV
11 beta hydroxylase deficiency
honey crusted lesions common around nose/lips
HELLP syndrome

7. Decreased efficacy - decreased Vmax
anti - epithelial antibodies
opioid withdrawal
dose response curve with noncompetitive antagonist
first line for absence seizures

8. H. Influenza
Galactocerebrosidase deficiency
plenta accreta
gram + bacteria that requires NAD and hemin for growth
brain tumor with fried egg appearance

9. Bilateral renal agenesis or posterior urethral valves in males
oligohydramnios
anti - mitochondrial antibodies
best effect of triglycerides/VLDL
MofA Levothyroxine

10. Actinomyces
most common lysosomal storage disease
astrocytes
BCG PQRS
branching rods on oral infection

11. DiGeorge
MPTP exposure causes depletion of what NT?
failure of endodermal development
crinkled paper cytoplasm
cells destroyed in Guillain Barre

12. HTN; XY will be a girl - XX will lack secondary sex char.
low dose ASA effects - intermediate dose - high dose
17 alpha hydroxylase deficiency
anti - platelet antibodies
Conn's syndrome

13. PNH
hemosiderinurea and thrombosis
iduronidase sulfatase
most common breast tumor in women under 25
brain tumor a/w von hipple - linadu syndrome

14. CCK
brain tumor with psammona bodies
Shigella
I cells
form multinucleated giant cells in the CNS when infected with HIV

15. S-100
brain tumor a/w von hipple - linadu syndrome
SE: elevated LFTS - myositis
benzos antidote
melanoma tumor marker

16. Hurlers
locus ceruleus
TZD (glitazones) MofA
corneal clouding & MR
lysosomal storage disease a/w renal disease

17. Von Hippel Lindau
leydig cell tumor
alpha L iduronidase
hemangioblastomas of retina/cerebellum/medulla
drug that blocks purine synthesis and is metabolized by xanthine oxidase

18. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
GM2 ganglioside accumulation
crinkled paper cytoplasm
BCG PQRS
H. flu

19. Decreases conversion
G cells
Conn's syndrome
PTU
5 alpha reductase deficiency

20. Huntingtons chorea
form multinucleated giant cells in the CNS when infected with HIV
pt has extended expiratory phase
Schiller Duval bodies
chromosome 4

21. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
rate limiting step in carb digestion
BCG PQRS
anti - mitochondrial antibodies
TZD (glitazones) MofA

22. Fibrates
ambiguous nucleus
Where does the spinothalamic decussate?
best effect of triglycerides/VLDL
what inhibits prolactin secretion

23. Regenerates glutathione
best effect of triglycerides/VLDL
D cells
branching rods on oral infection
MofA of N- aceylcysteine

24. Membranoproliferative GN
tram - track on microscope
what meds treat malaria
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
probenecid

25. Pepsin
PGI2 (prostacyclin))
brain tumor a/w von hipple - linadu syndrome
brain tumor with psammona bodies
chief cells

26. Motor innervation of pharynx - larynx and upper esophagus
honey crusted lesions common around nose/lips
ambiguous nucleus
I cells
sarcoma botyroides

27. Astrocytoma & glioblastoma multiforme
child with eczema - coarse facial features - cold abscesses
GFAP positive
Shigella
first line for absence seizures

28. Lymphoma

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29. Motor
Addison's
VA/VL
antibody against philadelphia chromosome
what checkpoint is p53 involved with?

30. Lactic acidosis
3 tumors of MEN 2a
which nerve lifts the eyelid?
metformin side effect
H. flu

31. Hypoglycemia
kluver bucy
t - PA - streptokinase antidote
what cells secrete somatostatin
sulfonylureas side effect

32. HTN; masculinization
what meds treat malaria
beta glucocerebrosidase
11 beta hydroxylase deficiency
honey crusted lesions common around nose/lips

33. Oligosaccaride hydrolase
honey crusted lesions common around nose/lips
brain tumor a/w von hipple - linadu syndrome
rate limiting step in carb digestion
homer wright rosettes

34. Medullary
cause of high pH vaginal discharge
subluxation of lens
alpha 1 anti - trypsin
cancer arising from parafollicular C cells

35. Second most common type of thyroid cancer
lead antidote
neutrophils fail to respond to chemotaxic stimuli
follicular
TZD (glitazones) MofA

36. ADPKD
lead antidote
brain tumor a/w von hipple - linadu syndrome
most common protozoal infection in US
mitral valve prolapse - liver diseae - berry aneurysm

37. Homocystienuria - Marfans
astrocytes
parietal cells
catalase positive coagulase negative
subluxation of lens

38. Schwann cells
tumor with call - exner bodies
PTU
deficiency of mannose phosphorylation
cells destroyed in Guillain Barre

39. 2 sperm + 1 egg (fetal parts present)
cause of low pH vaginal discharge
partial mole components
sphingomyelinase deficiency
lead antidote

40. Superchiasmic nucleus
intranuclear inclusions seen in herpes simplex encephalitis
5 alpha reductase deficiency
von Hippel Lindau disease
master clock for circadian rhythms

41. Hunters
What are the hormone changes seen in menopause
3 tumors of MEN 2b
mitral valve prolapse - liver diseae - berry aneurysm
iduronidase sulfatase

42. D cells of pancreas and gut
heXosaminidase
melanoma tumor marker
what cells secrete somatostatin
absent UTPGT

43. Membranous GN
spike and dome on microscope
best effect on HDL
what inhibits prolactin secretion
most common arrthymia

44. Penicillamine
copper - arsenic - gold antidote
11 beta hydroxylase deficiency
tram - track on microscope
5 alpha reductase deficiency

45. Basal cell carcinoma
oligohydramnios
benzos antidote
first line for cardiogenic shock
palisading nuclei - locally invasive

46. NF 1
what nerve innervates the muscles of mastication?
astrocytes
sclerosing adenosis
pigmented iris hamartomas - neural tumors

47. Antitoxin - penicillin - DPT vaccine
diphtheria treatment
alpha 1 anti - trypsin
Lewy bodies composition
papillary thyroid cancer

48. Thryroxine replacement
MofA of N- aceylcysteine
3 tumors of MEN 2b
What hormones share a common alpha subunit
MofA Levothyroxine

49. Decreased potency - increased Km
what checkpoint is p53 involved with?
increased MCHC and hemolytic anemia
dose response curve change with competitive antagonist
lead antidote

50. Dobutamine
first line for cardiogenic shock
sulfonylureas
UMN signs
Where does the spinothalamic decussate?