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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Hairless skin - dynamic fine touch
most common primary cardiac tumor in kiddos
meissners
chief cells
cells destroyed in MS

2. Bruton's agammaglobulinemia
What artery causes locked in syndrome
follicular
defective tyrosine kinase
looks like fried eggs under histologic staining

3. Hurlers
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension
metformin side effect
sphingomyelinase deficiency
alpha L iduronidase

4. A/w esophageal/duodenal atresia and anencephaly
granulosa cell tumor secretes what?
polyhydramnios
5 alpha reductase deficiency
Lateral geniculate nucleus

5. Rheumatic fever
dose response curve change with competitive antagonist
S cells
Aschoff bodies
chief cells

6. Visceral sensory
MPTP exposure causes depletion of what NT?
solitarius nucleus
failure of endodermal development
GFAP positive

7. Impetigo
honey crusted lesions common around nose/lips
protease inhibitors MofA
hippocampus
branching rods on oral infection

8. SICK PEG
schwann cells
P450 Inhibitors
astrocytes
abruptio placentae

9. A few levels above the level of entry
gram + bacteria that requires NAD and hemin for growth
H. flu
Where does the spinothalamic decussate?
thromboxane A2

10. Hurlers
G cells
P450 inducers
corneal clouding & MR
homer wright rosettes

11. Inhibits osteoclastic activity
BCG PQRS
Bisphosphonates MofA
whats the V/Q at the base of the lung
what inhibits prolactin secretion

12. Facial sensation (Make up on your face)
ventral posterior nucleus - medial part
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
ovarian tumor that resembles bladder epithelium
colchicine

13. Autosomal dominant
thayer martin media
deficiency of mannose phosphorylation
most common lysosomal storage disease
inheritance pattern for all MENs

14. Causes vasoconstriction (use for acute migraines)
most common primary cardiac tumor in kiddos
sumatriptan
anti - epithelial antibodies
medial geniculate nucleus

15. Visual (Lateral for Light)
tumor composed of cytotrophoblasts and syncytiotrophoblasts
Lateral geniculate nucleus
thymidylate synthase
rabies

16. Marfans
ovarian tumor with elevate hCG
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
kluver bucy
whats the V/Q at the base of the lung

17. Criglar Najar
absent UTPGT
diphtheria treatment
cause of increased myometrial excitability
anti - mitochondrial antibodies

18. I- cell disease
deficiency of mannose phosphorylation
resembles an onion in cross section
etanercept
Conn's syndrome

19. Barbituates - carbamazapine - griseofulvin - phenytoin - quinidine - rifampin - St. John's wort
BCG PQRS
most common breast cancer
meissners
11 beta hydroxylase deficiency

20. Alpha synuclein
Conn's syndrome
pigmented iris hamartomas - neural tumors
lewy body composition
what cells secrete somatostatin

21. ADPKD
LTB4
P450 Inhibitors
most common primary cardiac tumor in kiddos
mitral valve prolapse - liver diseae - berry aneurysm

22. Serotonin
x- linked recessive lysosomal storage diseases
UMN signs
S cells
raphe nucleus

23. Ethosuximide
hemosiderinurea + thrombosis
what cells secrete somatostatin
PTU
first line for absence seizures

24. PNH
3 tumors of MEN 2b
hemosiderinurea and thrombosis
benzos antidote
placenta previa

25. Function as bronchoconstrictors - vasoconstrictors - sm mm contraction and increased vascular permability
whats the V/Q at the apex of the lung
H. flu
treatment for SIADH
LT C4 D4 E4

26. Gauchers
5 alpha reductase deficiency
crinkled paper cytoplasm
most common lysosomal storage disease
low dose ASA effects - intermediate dose - high dose

27. Radial nerve - deep brachial artery
midshaft break of humerus
shown to slow progression of diabetic neuropathy
whats the V/Q at the apex of the lung
tram - track on microscope

28. Dantrolene (prevents release of calcium from SR of muscle)
thromboxane A2
drug induced lupus
treatment of malignant hyperthermia
basal nucleus of Meynert

29. Primary biliary cirrhosis
dose response curve change with competitive antagonist
basal nucleus of Meynert
anti - mitochondrial antibodies
first line for cardiogenic shock

30. Cocain and sumatriptan
meissners
What causes coronary vasospasm as a SE?
treatment of malignant hyperthermia
Abciximab

31. Flumazenil
What are the hormone changes seen in menopause
cancer arising from parafollicular C cells
PTU
benzos antidote

32. Amygdala
kluver bucy
first line for cardiogenic shock
sulfonylureas
GABA - glutamine

33. Second most common type of thyroid cancer
MofA of N- aceylcysteine
pseudopalisading necrosis
follicular
UMN signs

34. 6- mecaptopurine (metabolized by xanthine oxidase)
bocks PRPP synthetase to block purine synthesis
HELLP syndrome
Where does the lateral corticospinal decussate?
SE: torsades de pointes

35. Choriocarcinoma
best effect of triglycerides/VLDL
tumor composed of cytotrophoblasts and syncytiotrophoblasts
placenta previa
21 hydroxylase deficiency

36. Hurlers - Hunters
most common breast mass in postmenopausal women
propylthiouracil side effects
dermatin sulfate accumulation
sumatriptan

37. Microglia
cause of high pH vaginal discharge
SE: torsades de pointes
form multinucleated giant cells in the CNS when infected with HIV
chief cells

38. Gonorrhea
drug that blocks purine synthesis and is metabolized by xanthine oxidase
tumor with call - exner bodies
thayer martin media
What anti - hypertensive drug has the side effect of first dose orthostatic hypotension

39. Polyarteritis nodosa
rate limiting step in carb digestion
vasculitis a/w Hep B
preeclampsia
G cells

40. Fabry's & Hunters
gram + bacteria that requires NAD and hemin for growth
brain tumor with perivascular pseudorosettes
x- linked recessive lysosomal storage diseases
Where does the spinothalamic decussate?

41. Alpha feto protein
most common lysosomal storage disease
anti - epithelial antibodies
Yolk sac tumor produces...
heparin antidote

42. Bind viral gp41 subunit
fusion inhibitors
TZD (glitazones) MofA
subluxation of lens
lysosomal storage disease - demyelinating disease

43. Wiscott - Aldrich
anti - mitochondrial antibodies
propylthiouracil side effects
eczema/recurrent infections/thrombocytopenia
cancer associated with Hashimoto's thyroiditis

44. Ovarian bengin tumor...looks like bladder
tumor composed of cytotrophoblasts and syncytiotrophoblasts
corneal clouding & MR
alpha 1 anti - trypsin
brenner tumor

45. Tay Sachs
GM2 ganglioside accumulation
SE: torsades de pointes
what checkpoint is p53 involved with?
neutrophils fail to respond to chemotaxic stimuli

46. Demeclycocycline or water restriction
drug induced lupus
glycine
treatment for SIADH
brain tumor with foamy cells and high vascularity

47. Von Hippel Lindau
LT C4 D4 E4
hemosiderinurea and thrombosis
hemangioblastomas of retina/cerebellum/medulla
hallmark sign of COPD

48. Dimercaprol
etanercept
ovarian tumor that resembles bladder epithelium
currant jelly stool
lead antidote

49. Cowdry type A inclusions
intranuclear inclusions seen in herpes simplex encephalitis
colchicine
spike and dome on microscope
copper - arsenic - gold antidote

50. Meissner
Where does the dorsal column decussate?
shown to slow progression of diabetic neuropathy
LMN signs
found in hairless skin