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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Ethosuximide
first line for absence seizures
follicular
What thyroid pathology has an extremely tender thyroid gland
erythema nodosum

2. Obstructive - COPD
dorsal motor nucleus
infliximab
pt has extended expiratory phase
MofA Levothyroxine

3. Depolymerizes microtubules - impairing leukocyte chemotaxis and degranulation
best effect of triglycerides/VLDL
cause of malignant hyperthermia
parietal cells
colchicine

4. I- cell disease
nucleoside reverse transcriptase inhibitors
ovarian tumor with psammoma bodies
deficiency of mannose phosphorylation
anti - epithelial antibodies

5. Cause release of preformed insulin
grossly black liver
epithelial
sulfonylureas
lisch nodules

6. Fabrys
benzos antidote
alpha galacosidase A
microglia
LMN signs

7. Port wine stains - ipsilateral leptomeningeal angioma; can cause glaucoma - seizures - hemipareis - and MR
catalase negative
Schiller Duval bodies
cells destroyed in Guillain Barre
sturge weber syndrome

8. Anti - TNF antibody - use for RA but watch out for latent TB!
microglia
infliximab
pacinian
What artery causes locked in syndrome

9. Polyarteritis nodosa
blood supply for thalamus
vasculitis a/w Hep B
cause of increased myometrial excitability
Addison's

10. Tay SaX
abruptio placentae
copper - arsenic - gold antidote
heXosaminidase
antibiotic with SE of eosinophilia

11. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
sarcoma botyroides
meissners
papillary thyroid cancer
hemosiderinurea and thrombosis

12. Cells of BBB
S cells
astrocytes
anti - epithelial antibodies
master clock for circadian rhythms

13. Huntingtons chorea
chromosome 4
FGFR3 mutation
nucleoside reverse transcriptase inhibitors
grossly black liver

14. Fabry's & Hunters
meissners
x- linked recessive lysosomal storage diseases
lysosomal storage disease - demyelinating disease
testicular tumor that can present with gynecomastia

15. Microglia
form multinucleated giant cells in the CNS when infected with HIV
11 beta hydroxylase deficiency
antibody against philadelphia chromosome
pigmented iris hamartomas - neural tumors

16. Niacins
best effect on HDL
drug induced lupus
brain tumor with fried egg appearance
ambiguous nucleus

17. Medulla
Where does the lateral corticospinal decussate?
most common primary cardiac tumor in kiddos
found in hairless skin
nucleoside reverse transcriptase inhibitors

18. Cocain and sumatriptan
hemosiderinurea and thrombosis
cells destroyed in Guillain Barre
What causes coronary vasospasm as a SE?
G cells

19. Hurlers - Hunters
hep B seropositivity in 30% of patients
raphe nucleus
dermatin sulfate accumulation
mitral valve prolapse - liver diseae - berry aneurysm

20. Glioblastoma multiforme
myelinates on PNS
tumor composed of cytotrophoblasts and syncytiotrophoblasts
ambiguous nucleus
pseudopalisading necrosis

21. Cowdry type A inclusions
intranuclear inclusions seen in herpes simplex encephalitis
astrocytes
defective tyrosine kinase
VA/VL

22. Oculomotor
which nerve lifts the eyelid?
kawasaki
fusion inhibitors
ventral posterior nucleus - lateral part

23. Damaged in multiple sclerosis
increased MCHC and hemolytic anemia
oligodendrioglia
SICK PEG
GABA - glutamine

24. Decreased follicles & estrogen with increased FSH & LH
What hormones share a common alpha subunit
defective tyrosine kinase
sarcoma botyroides
What are the hormone changes seen in menopause

25. PPAR- gamma receptor agonist - which causes improved target cell response to insulin
TZD (glitazones) MofA
21 hydroxylase deficiency
heXosaminidase
myelinates multiple CNS axons

26. Gilberts
mildly decreased UDPGT
erythema nodosum
homer wright rosettes
cells destroyed in MS

27. Hemolysis - elevated LFTs - Low Platelets
low dose ASA effects - intermediate dose - high dose
medial geniculate nucleus
HELLP syndrome
dose response curve with noncompetitive antagonist

28. Clopidogrel - ticoplidine
kluver bucy
blocks ADP receptors to inhibit platelet aggregation
cough - conjunctivitis - coryza - fever
11 beta hydroxylase deficiency

29. Glucuronyl transferase
anti - platelet antibodies
sphingomyelinase deficiency
3 tumors of MEN 2a
enzyme used to conjugate bilirubin

30. Seborric keratosis
keratin filled cysts
GFAP positive
silver stain of gram negative rods
most common breast tumor in women under 25

31. Hereditary spherocytosis
cells destroyed in MS
plenta accreta
MofA of N- aceylcysteine
increased MCHC and hemolytic anemia

32. Rhabdomyoma
pigmented iris hamartomas - neural tumors
whats the V/Q at the base of the lung
MofA Levothyroxine
most common primary cardiac tumor in kiddos

33. Thryroxine replacement
homer wright rosettes
MofA Levothyroxine
cause of increased myometrial excitability
testicular tumor that can present with gynecomastia

34. Bilateral renal agenesis or posterior urethral valves in males
oligohydramnios
myelinates on PNS
complete mole components
whats the V/Q at the apex of the lung

35. 2 sperm + empty egg (no fetal parts)
LMN signs
P450 inducers
plenta accreta
complete mole components

36. D cells of pancreas and gut
meissners
kawasaki
what cells secrete somatostatin
blocks ADP receptors to inhibit platelet aggregation

37. Dubin Johnson
11 beta hydroxylase deficiency
lysosomal storage disease - demyelinating disease
brain tumor with psammona bodies
grossly black liver

38. Tay Sachs
catalase positive coagulase negative
hep B seropositivity in 30% of patients
silver stain of gram negative rods
GM2 ganglioside accumulation

39. Wiscott - Aldrich
cause of high pH vaginal discharge
locus ceruleus
eczema/recurrent infections/thrombocytopenia
protease inhibitors MofA

40. Yolk sac
chromosome 4
cause of low pH vaginal discharge
P450 Inhibitors
most common testicular tumor in infants and children up to 3 years of age

41. Niacin
order of nerve blockade
3 tumors of MEN 1
Where does the spinothalamic decussate?
SE: facial flushing

42. H. Influenza
hydrocele
treatment of malignant hyperthermia
tram - track on microscope
gram + bacteria that requires NAD and hemin for growth

43. Macrolides
what cells secrete somatostatin
antibiotic with SE of eosinophilia
anti - platelet antibodies
absent UTPGT

44. Hairless skin - dynamic fine touch
most common testicular tumor in infants and children up to 3 years of age
intranuclear inclusions seen in herpes simplex encephalitis
Yolk sac tumor produces...
meissners

45. Hypoglycemia
lysosomal storage disease a/w renal disease
sulfonylureas side effect
What are the hormone changes seen in menopause
catalase positive coagulase negative

46. Actinomyces
lisch nodules
branching rods on oral infection
heXosaminidase
mitral valve prolapse - liver diseae - berry aneurysm

47. TNF receptor
etanercept
dose response curve change with competitive antagonist
3 tumors of MEN 2a
P450 Inhibitors

48. Chocolate agar
lysosomal storage disease a/w renal disease
myelinates multiple CNS axons
H. flu
Schiller Duval bodies

49. Actinomyces
child with partial albinism - peripherial neuropathy - recurrent infections
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
branching rods on oral infection
most common lysosomal storage disease

50. 6- MP
drug that blocks purine synthesis and is metabolized by xanthine oxidase
optically clear nuclei (orphan annie)
oligodendrioglia
branching rods on oral infection