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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Medulla
Where does the dorsal column decussate?
deficiency of mannose phosphorylation
dorsal motor nucleus
11 beta hydroxylase deficiency

2. Staph epidermidis - staph sapro
complete mole components
probenecid
catalase positive coagulase negative
meissners

3. G1/S & G2/M
anti - epithelial antibodies
ovarian tumor that resembles bladder epithelium
rabies
what checkpoint is p53 involved with?

4. Inhibits platelet aggregation - promotes vasodilation and decreases uterine tone
most common testicular tumor in infants and children up to 3 years of age
pseudopalisading necrosis
propylthiouracil side effects
PGI2 (prostacyclin))

5. Huntingtons chorea
blood supply for thalamus
alpha 1 anti - trypsin
chromosome 4
psammoma bodies

6. Chloroquine and primaquine
what meds treat malaria
21 hydroxylase deficiency
SE: elevated LFTS - myositis
blocks ADP receptors to inhibit platelet aggregation

7. Lymphoma

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8. Gauchers
GFAP positive
first line for absence seizures
cells destroyed in MS
crinkled paper cytoplasm

9. Radial nerve - deep brachial artery
lysosomal storage disease a/w renal disease
SE: facial flushing
midshaft break of humerus
11 beta hydroxylase deficiency

10. Cant convert testosterone to DHT - ambiguous genitalia until puberty then penis at 12
contains ovarian vessels
opioid withdrawal
first line for absence seizures
5 alpha reductase deficiency

11. 6- MP
schwann cells
myelinates on PNS
contains ovarian vessels
drug that blocks purine synthesis and is metabolized by xanthine oxidase

12. B. fragilis
alpha L iduronidase
sturge weber syndrome
most common bacteria in GI tract
GABA - glutamine

13. 2 sperm + empty egg (no fetal parts)
LT C4 D4 E4
PGI2 (prostacyclin))
complete mole components
anti - epithelial antibodies

14. Gauchers
best effect of triglycerides/VLDL
propylthiouracil side effects
most common lysosomal storage disease
blocks ADP receptors to inhibit platelet aggregation

15. Fibrates
lysosomal storage disease - demyelinating disease
basal nucleus of Meynert
FGFR3 mutation
best effect of triglycerides/VLDL

16. Tay SaX
heXosaminidase
HELLP syndrome
alpha galacosidase A
Where does the lateral corticospinal decussate?

17. Dubin Johnson
anti - platelet antibodies
grossly black liver
brain tumor with foamy cells and high vascularity
What hormones share a common alpha subunit

18. Lactic acidosis
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
deficiency of mannose phosphorylation
metformin side effect
leydig cell tumor

19. Papillary
thyroid cancer associtated with RET oncogene
floppy mitral valve dissecting aortic aneurysm - berry aneurysm
I cells
treatment for SIADH

20. Decreased follicles & estrogen with increased FSH & LH
cause of malignant hyperthermia
SE: facial flushing
What are the hormone changes seen in menopause
heparin antidote

21. Cause release of preformed insulin
catalase negative
sulfonylureas
melanoma tumor marker
What causes coronary vasospasm as a SE?

22. Meissner
abruptio placentae
failure of endodermal development
blood supply for thalamus
found in hairless skin

23. 0.6
whats the V/Q at the base of the lung
Lewy bodies composition
sumatriptan
child with eczema - coarse facial features - cold abscesses

24. Brenners tumor
ovarian tumor that resembles bladder epithelium
ependymal cells
adenomyosis
Lewy bodies composition

25. Serous cystadenocarcinoma
ovarian tumor with psammoma bodies
optically clear nuclei (orphan annie)
ependymal cells
most common testicular tumor

26. Port wine stains - ipsilateral leptomeningeal angioma; can cause glaucoma - seizures - hemipareis - and MR
treatment of malignant hyperthermia
child with partial albinism - peripherial neuropathy - recurrent infections
sturge weber syndrome
H. flu

27. HTN - proteinuria - edema
5 alpha reductase deficiency
drug induced lupus
spike and dome on microscope
preeclampsia

28. Metachromatic leukodystrophy
basal nucleus of Meynert
inheritance pattern for all MENs
solitarius nucleus
lysosomal storage disease - demyelinating disease

29. Body sensation
5 alpha reductase deficiency
basal nucleus of Meynert
found in hairless skin
ventral posterior nucleus - lateral part

30. Small diameter > large diameter; myelinated > unmyelinated
order of nerve blockade
most common first line agent for septic shock
absent UTPGT
found in hairless skin

31. 2 sperm + 1 egg (fetal parts present)
Conn's syndrome
PGI2 (prostacyclin))
drug induced lupus
partial mole components

32. Dobutamine
most common bacteria in GI tract
sclerosing adenosis
PTU
first line for cardiogenic shock

33. SICK PEG
precursor to GABA
barbituates withdrawal
P450 Inhibitors
strawberry tongue

34. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
pacinian
sarcoma botyroides
FGFR3 mutation
currant jelly stool

35. Oligodendrioma
brain tumor with fried egg appearance
cause of malignant hyperthermia
Where does the spinothalamic decussate?
crinkled paper cytoplasm

36. Hurlers - Hunters
dermatin sulfate accumulation
11 beta hydroxylase deficiency
sulfonylureas side effect
beta glucocerebrosidase

37. Streptococcus
catalase negative
SE: elevated LFTS - myositis
cancer arising from parafollicular C cells
failure of endodermal development

38. Antibody binds to gp2b/3a - preventing aggregation
Abciximab
most common primary cardiac tumor in kiddos
master clock for circadian rhythms
infliximab

39. Choriocarcinoma
tumor composed of cytotrophoblasts and syncytiotrophoblasts
Lewy bodies composition
11 beta hydroxylase deficiency
ovarian tumor that resembles bladder epithelium

40. Seborric keratosis
complete mole components
locus ceruleus
Lateral geniculate nucleus
keratin filled cysts

41. Imabtinib
diphtheria treatment
locus ceruleus
pacinian
antibody against philadelphia chromosome

42. Makes oxytocin
Shigella
deficiency of mannose phosphorylation
metformin side effect
paraventricular nucleus of hypothalamus

43. SCID
best effect on HDL
child with eczema - coarse facial features - cold abscesses
antibody against philadelphia chromosome
etanercept

44. Pemphigus vulgaris
SE: facial flushing
chief cells
anti - epithelial antibodies
neutrophils fail to respond to chemotaxic stimuli

45. BCG PQRS
P450 inducers
ambiguous nucleus
precursor to GABA
colchicine

46. Oligodendoglia
myelinates multiple CNS axons
mitral valve prolapse - liver diseae - berry aneurysm
midshaft break of humerus
Abciximab

47. Dissociative
may lead to multiple personalities
bocks PRPP synthetase to block purine synthesis
optically clear nuclei (orphan annie)
branching rods on oral infection

48. Schwann cells
myelinates on PNS
brain tumor with psammona bodies
cells destroyed in Guillain Barre
anti - mitochondrial antibodies

49. Estrogen (causes precocious puberty)
I cells
Bisphosphonates MofA
granulosa cell tumor secretes what?
precursor to GABA

50. Inhibitory in the SC
glycine
increased MCHC and hemolytic anemia
alpha L iduronidase
complete mole components