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USMLE Pathophys

Instructions:

Answer 50 questions in 15 minutes.
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Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.

1. Lymphoma

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2. Fibrocystic
myelinates multiple CNS axons
most common breast mass in pre - menopausal women
ambiguous nucleus
which nerve lifts the eyelid?

3. Polyarteritis nodosa
alpha 1 anti - trypsin
hemosiderinurea + thrombosis
hep B seropositivity in 30% of patients
hydrocele

4. NE
opioids antidote
P450 Inhibitors
LT C4 D4 E4
most common first line agent for septic shock

5. ITP
anti - platelet antibodies
ovarian tumor with psammoma bodies
melanoma tumor marker
meissners

6. Ethosuximide
most common lysosomal storage disease
PTU
grossly black liver
first line for absence seizures

7. Hairless skin - dynamic fine touch
brenner tumor
meissners
branching rods on oral infection
master clock for circadian rhythms

8. Gonorrhea
5 alpha reductase deficiency
thayer martin media
master clock for circadian rhythms
branching rods on oral infection

9. Seminoma
PTU
most common testicular tumor
lysosomal storage disease - demyelinating disease
What artery causes locked in syndrome

10. SICK PEG
mildly decreased UDPGT
von Hippel Lindau disease
P450 Inhibitors
GFAP positive

11. Benign - contains Reinke crystals - usually androgen producing
What causes coronary vasospasm as a SE?
GFAP positive
etanercept
leydig cell tumor

12. Anti - TNF antibody - use for RA but watch out for latent TB!
infliximab
kawasaki
pt has extended expiratory phase
most common testicular tumor in infants and children up to 3 years of age

13. Polyarteritis nodosa
vasculitis a/w Hep B
kawasaki
copper - arsenic - gold antidote
order of nerve blockade

14. Subacute (De Quervain's) thyroiditis
t - PA - streptokinase antidote
rate limiting step in carb digestion
What thyroid pathology has an extremely tender thyroid gland
iduronidase sulfatase

15. Anxiety - insomnia - sweating - dilated pupils - piloerection - rhinorrhea
branching rods on oral infection
parietal cells
opioid withdrawal
sphingomyelinase deficiency

16. ADPKD
fusion inhibitors
low dose ASA effects - intermediate dose - high dose
keratin filled cysts
mitral valve prolapse - liver diseae - berry aneurysm

17. Decreases platelet aggregation - anti - pyretic and analgesic - high dose is anti - inflammatory
antibiotic with SE of eosinophilia
oligodendrioglia
low dose ASA effects - intermediate dose - high dose
What are the hormone changes seen in menopause

18. Obstructive - COPD
t - PA - streptokinase antidote
pt has extended expiratory phase
what checkpoint is p53 involved with?
child with eczema - coarse facial features - cold abscesses

19. Choriocarcinoma or dysgerminoma
ovarian tumor with elevate hCG
what checkpoint is p53 involved with?
diphtheria treatment
schwann cells

20. Niacins
best effect on HDL
3 tumors of MEN 1
astrocytes
enzyme used to conjugate bilirubin

21. Sulfonamides - Isonizid - Cimetidine - Ketoconazole - Erythromyicn - grapefruit juice - protease inhibitors
SICK PEG
hallmark sign of COPD
lysosomal storage disease - demyelinating disease
best effect on HDL

22. Estrogen
What artery causes locked in syndrome
drug that blocks purine synthesis and is metabolized by xanthine oxidase
infliximab
cause of increased myometrial excitability

23. Ependymoma
GABA - glutamine
anti - epithelial antibodies
brain tumor with perivascular pseudorosettes
looks like fried eggs under histologic staining

24. Ret
glycine
What oncogene is a/w MEN 2a/b
sulfonylureas MofA
testicular tumor that can present with gynecomastia

25. Makes ADH
FGFR3 mutation
TZD (glitazones) MofA
diphtheria treatment
supraoptic nucleus of hypothalamus

26. Chocolate agar
etanercept
most common breast cancer
H. flu
child with eczema - coarse facial features - cold abscesses

27. Actinomyces
branching rods on oral infection
dose response curve change with competitive antagonist
cause of malignant hyperthermia
t - PA - streptokinase antidote

28. Hurlers
corneal clouding & MR
contains ovarian vessels
macrolides use (PUS)
best effect of triglycerides/VLDL

29. Primary biliary cirrhosis
first line for absence seizures
heXosaminidase
anti - mitochondrial antibodies
palisading nuclei - locally invasive

30. Dobutamine
master clock for circadian rhythms
first line for cardiogenic shock
thromboxane A2
low dose ASA effects - intermediate dose - high dose

31. Visceral sensory
What hormones share a common alpha subunit
basal nucleus of Meynert
etanercept
solitarius nucleus

32. Macrophages of the CNS
parietal cells
microglia
child with eczema - coarse facial features - cold abscesses
GFAP positive

33. Norepinephrine
brain tumor a/w von hipple - linadu syndrome
protease inhibitors MofA
locus ceruleus
most common arrthymia

34. Meningioma
brain tumor with psammona bodies
mildly decreased UDPGT
strawberry tongue
epithelial

35. Vaginal carcinoma: spindle shaped tumor cells that are desmin positive
heparin antidote
copper - arsenic - gold antidote
sarcoma botyroides
chromosome 4

36. Anxiety - seizures - delirium - life threatening CV collapse
copper - arsenic - gold antidote
neutrophils fail to respond to chemotaxic stimuli
plenta accreta
barbituates withdrawal

37. Glucuronyl transferase
What artery causes locked in syndrome
cancer arising from parafollicular C cells
anti - epithelial antibodies
enzyme used to conjugate bilirubin

38. Second most common type of thyroid cancer
anti - epithelial antibodies
Bisphosphonates MofA
pseudopalisading necrosis
follicular

39. Fabry's
PGI2 (prostacyclin))
lysosomal storage disease a/w renal disease
myelinates on PNS
cause of malignant hyperthermia

40. Gilberts
brain tumor with fried egg appearance
mildly decreased UDPGT
optically clear nuclei (orphan annie)
17 alpha hydroxylase deficiency

41. Homocystienuria - Marfans
subluxation of lens
honey crusted lesions common around nose/lips
polyhydramnios
thyroid cancer associtated with RET oncogene

42. Increases platelet aggregation and vasoconstriction
thromboxane A2
defective tyrosine kinase
opioid withdrawal
spike and dome on microscope

43. Inhibitory in the brain - stimulatory in the brain
GABA - glutamine
what meds treat malaria
what inhibits prolactin secretion
chromosome 4

44. Hurlers - Hunters
thymidylate synthase
H. flu
dermatin sulfate accumulation
GFAP positive

45. Astrocytoma & glioblastoma multiforme
MPTP exposure causes depletion of what NT?
I cells
PGI2 (prostacyclin))
GFAP positive

46. Auditory (Medial for Music)
medial geniculate nucleus
corneal clouding & MR
pacinian
ovarian tumor that resembles bladder epithelium

47. Hereditary spherocytosis
increased MCHC and hemolytic anemia
MPTP exposure causes depletion of what NT?
GFAP positive
tumor with call - exner bodies

48. Clopidogrel - ticoplidine
optically clear nuclei (orphan annie)
mildly decreased UDPGT
blocks ADP receptors to inhibit platelet aggregation
deficiency of mannose phosphorylation

49. Metachromatic leukodystrophy
lysosomal storage disease - demyelinating disease
strawberry tongue
form multinucleated giant cells in the CNS when infected with HIV
plenta accreta

50. Schwann cells
cells destroyed in Guillain Barre
form multinucleated giant cells in the CNS when infected with HIV
Lateral geniculate nucleus
master clock for circadian rhythms