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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. is CPSII or CPSI involved in pyrimidine synthesis?






2. Where does a majority of galactose in our diet come from?






3. Homocysteine gets turned into methionine by...






4. What metabolic reactions occur in the cytoplasm?






5. AD disease...






6. What does a def in folic acid cause? is it more or less common than cobalamin def? How do you differentiate it with cobalamin def?






7. What are the clinical symptoms associated with fragile X syndrome?






8. What is the most common cause of Osteogenesis Imperfecta? What is the inheritance pattern?






9. What is the degradation product of dopamine?






10. What is most often mutated in xeroderma pigmentosum? What is the inheritance pattern? What are the clinical symptoms?






11. What causes an excess of B3? What are the symptoms?






12. What is the difference between methotrexate and trimethroprim?






13. What does topoisomerase do? I or II eukaryotic?






14. Findings for Cori's disease? deficient enzyme?






15. What vesicular trafficking protein takes proteins from the Golgi to lysosomes? in between the golgi? from the plasma membrane to endosomes (receptor mediated endocytosis)?






16. What converts fructose 2 -6 phosphate back to fructose 2 phosphate?






17. Other than being hereditary - What are two other ways you can have a lack of brush border enzymes?






18. What aa is the ultimate precursor of catecholamine synthesis?






19. What is the effect of the Cardiac glycosides?






20. In What cells does the Respiratory burst occur? Where is NADPH located in the cell? What is this reaction important for?






21. What explains the excess phenylketones in the urine in phenylketonuria?






22. Fructose 2 -6 bisphophate is involved in...






23. What is a telangiectasia? Where can they be found?and What is a common result of them?






24. What is the major cause of SCID? What does SCID stand for?






25. The mode of inheritance for both NF disease is...






26. How are senescent cells different from some neoplastic and germ cells? What does this substance do?

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27. What glucose is stored as






28. Heterozygous females in X linked recessive disease...






29. In protein translation - What is the 'A' site for? 'P' site? 'E' site? What is the exception to this?

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30. After how long of starvation do glycogen reserves deplete? after this occurs - how are blood glucose levels maintained?






31. Name a few intermediate filament defects. hints: alcohol - 2 neuro dx

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32. What step in pyrimidine synthesis requires aspartate?






33. Which metabolic reactions require both the mit and cytosol?






34. What enzyme converts norepinephrine to epinephrine? using What cofactor?






35. What two anti - neoplastic drugs work by blocking DNA and RNA polymerase?






36. What are the lab findings see in hyperammonemia?






37. What is the signal for adenylation? What enzyme does? does it require a template?






38. Which lysosomal storage diseases have enzymes that are def in cells that are neuronal mostly?






39. Do RNA polymerases have proofreading function? What does this mean for HIV?






40. What is the most abundant protein in the body? From What cell type is it made? How many types are there? Where is it found (generally)?






41. What are the findings in alkaptonuria? why do they occur?






42. What converts dopa into melanin?






43. Which amino acids are acidic? are they negatively or positively charged at body pH?






44. What is the result of arginase deficiency?






45. Glucokinase is a...






46. why does branching occur in glycogenesis?






47. What is the pathogenesis of fragile x syndrome?






48. From What aa do NAD+ and NADP+ come from?






49. In What genetic code is uracil found in? in replace of what?






50. What creates a frameshift mutation? What are some clinical examples?







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