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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is carnitine deficiency and What does it result in?






2. What converts pyruvate to Acetyl CoA ? What allosterically downregulates this enzyme?






3. What is phenylethanolamine N- methyl transferase located?






4. Like mRNA has a poly A tail on the 3' end - What does tRNA have on its 3' end? What happens here?






5. Which Hurlers is milder and presents with no corneal clouding?






6. What enzyme is used in the oxidative phase of HMP shunt? nonoxidative?






7. What enzyme is deficient in galactokinase deficiency? What are the symptoms?






8. What is the rate determining enzyme in urea cycle?






9. Daughters of Xlinked recessive diseased fathers are...






10. Where is anaerobic glycolysis used often?






11. What is the major cause of B12 def? What is the clinical picture of this?






12. What is the mcc of an autosomal trisomy?






13. The mode of inheritance for both NF disease is...






14. deamination of What pyrimidine makes what?






15. What is main lab finding in Lesch Nyhan syndrome? due to What enzyme deficiency? What reaction is deficient?






16. In What cells does the Respiratory burst occur? Where is NADPH located in the cell? What is this reaction important for?






17. What disease is associated with chromosome 17?






18. What can cause a vit C deficiency?






19. What is the effect of defiiency of VIt E?






20. What factors is Vit K responsible for the synthesis? and What else?






21. What aa degradation disorder results in atherosclerosis? debiltating arthralgias? osteoporosis?






22. Phenylethanolamine N- methyl is only located in the...






23. After citrulline is produced and in the cytoplasm What happens next in the urea cycle?






24. What is the source of Biotin?






25. How do hepatocytes release glucose 6 P from glycogenolysis into the blood ? in What disease is this enzyme deficient?






26. What is most often mutated in xeroderma pigmentosum? What is the inheritance pattern? What are the clinical symptoms?






27. What two anti - neoplastic drugs work by blocking DNA and RNA polymerase?






28. What are required for splicing? encoded by What polymerase?






29. Where is type 1 collagen found?






30. What are the three results that come from increased NADH in alcohol metabolism?






31. What is Pleiotropy? What is the opposite of Pleiotropy? Give an example of each.






32. What can cause hypervitaminosis D?






33. How do digoxin and digitoxin work? What class of drugs are they?






34. What are the functions of Microtubule proteins?






35. What is imprinting?






36. What goes on with G0 cell cycle phase?






37. What are the key intermediates in the TCA?






38. What aa becomes essential with homocystinuria? phenylalaninuria?






39. What disease is associated with chromosome 7?






40. AR disease are usually...






41. Which amino acids are acidic? are they negatively or positively charged at body pH?






42. What disease is associated with chromosome 15?

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43. What are the four irreversible enzymes of gluconeogenesis and Where in the cell are they found? Which is deficient in von gierkes disease?






44. Which cells have the most FA and thus are the most susceptible to FR injury?






45. What kind of DNA damage does ionizing radiation cause? What type of repair helps with this?






46. What does methotrexate do? What step is this enzyme involved in?






47. With What gene are MEN 2A and 2B associated with?






48. What carries activated Phosphate groups?






49. What happens to homocysteine after converting a methyl?






50. What causes an excess of B3? What are the symptoms?







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