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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What does methotrexate do? What step is this enzyme involved in?






2. What are the clinical symptoms of NF2?






3. What is the inheritance of CF? What is the pathogenesis of the disease?






4. What is dysgeusia?






5. How does lactate contribute to gluconeogenesis?






6. On a 100 meter sprint What is used as energy? in general What is the rule with exercise? What is used in 1000 meter run?






7. HMG coA synthase; cholesterol synthesis






8. What is the effect of defiiency of VIt E?






9. Which is the rate limiting step of the urea cycle?






10. What does the brain do with ketone bodies?






11. Ocular albinism is...






12. What is used in a marathon?






13. in What organ is the storage form of D3 converted to its active form? What enzyme? What hormone stimulates this action?






14. What is the main aa composition of collagen? What other 2 aa are common?






15. Which water soluble vitamins get stored in the liver with the fat soluble vitamins? Which has a greater pool of storage in the liver? Where do all the other water soluble vitamins go?






16. other than scurvy What else does vit C def cause? also - What kind of anemias and why?






17. What is the rate limiting step in fatty acid synthesis? What four things inhibit this rate limiting step? What stimulates it?






18. What is the treatment of hyperammonia?






19. The __________ adds O linked oligosaccharides to serine and threonine residues on proteins






20. Heterozygous females in X linked recessive disease...






21. What builds up in the urine in homogentistic acid oxidase deficiency? What does this result in ?






22. What are the results of the pregnancy screen for Downs?






23. What is a common result of unbalanced robertsonian translocation?






24. What goes on with G0 cell cycle phase?






25. other than being returned to methionine - What else is the fate of homocysteine? through What enzyme? with What cofactor?






26. What are the two main function of Vit E?






27. What is the rate limiting step in glycolysis? What does it do? who activates it? inhibits it?






28. IMP is degraded to inosine and then to hypoxanthine. What two options are next? by What enzymes?






29. What are the priorities in fasting and starvation?






30. Which Hurlers is milder and presents with no corneal clouding?






31. What disease is associated with chromosome 13?






32. What is the presentation of G6PD deficiency?






33. What is lebers hereditary optic neuropathy? What is the main clinical symptom? and What is its mode of inheritance?






34. What causes the lysosomal storage diseases?






35. What is this reaction dependent on?






36. What enzyme is involved in the degradation of tyrosine to fumarate?






37. What are two clinical symptoms of newborns with CF? and whats a lab value of a newborn with CF?






38. What carries 1 carbon units as energy?






39. From What aa does thyroxine come from?






40. What are the clinical symptoms of hyperammonemia?






41. What does vit C excess cause?






42. From What aa does GABA come from? with What enzyme? and What vit cofactor? What does GABA stand for?






43. in What disease are there antibodies to snRNPs?






44. What are the functions of zinc?






45. What does a pyridoxine deficiency look like? What causes it?






46. Increased levels of cAMP results in...






47. AD diseases are usually...






48. All glutamate goes to _______ d ammonia is used as a buffer in urine






49. Which intermediate filament is found connective tissue? muscle? epithelial cells? neuroglia? neurons? What can intermediate filaments be used for?






50. What are the glycogen storage disease? What they result in?






Can you answer 50 questions in 15 minutes?



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