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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What amino acids are required in purine synthesis? Which of these does pyrimidine synthesis require also?






2. What is the treatment for cystinuria?






3. Which oxidant is most attributable to damage of RBCs?






4. How do you differentiate causes of megaloblastic anemia?






5. What enzyme is deficient in maple syrup urine disease?






6. Homocysteine gets turned into methionine by...






7. What aa does melanin come from? melatonin?






8. HMG coA synthase; cholesterol synthesis






9. What are the three results that come from increased NADH in alcohol metabolism?






10. in What disease are there antibodies to snRNPs?






11. list three uncoupling agents






12. What is the effect of defiiency of VIt E?






13. What does ornithine transcarbamyolase do to carbamoyl phosphate?






14. What is the confirmation of Downs?






15. What disease is associated with chromosome 21?

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16. What is the order of cell cycle phases? What happens in each phase?






17. Where are ketone bodies made? What is the rate limiting enzyme? What are they made from?






18. What is the rate limiting step in cholesterol synthesis? What does it do?






19. What is imprinting disease? Give 2 examples






20. What else decreases production of oxaloacetate in alcoholism other than decreased pyruvate?






21. What is the function of Vit K?






22. What is the difference between the promoter and enhancer? in What process are they used for?






23. Breast milk has a little of...






24. Is PRPP added later or first in pyrimidine synthesis?






25. other than succinate dehydrogenase What other enzymes are found in the inner mit membrane?






26. Findings for McArdle's disease? deficient enzyme?






27. Which water soluble vitamins get stored in the liver with the fat soluble vitamins? Which has a greater pool of storage in the liver? Where do all the other water soluble vitamins go?






28. What causes the pathology in I- cell disease? What does I cell sidease






29. What is the main hormonal regulation of glycogen?






30. What vesicular trafficking protein takes proteins from the Golgi to lysosomes? in between the golgi? from the plasma membrane to endosomes (receptor mediated endocytosis)?






31. Daughters of Xlinked dominant diseased fathers are...






32. What happens in an aminotransferase reaction






33. What is the exception to the nonoverlapping/commaless aspect of the genetic code?






34. in What organ is the storage form of D3 converted to its active form? What enzyme? What hormone stimulates this action?






35. Where does a majority of galactose in our diet come from?






36. What are labile cells? Which cells are labile?






37. What three steps are included in RNA processing? Where does it occur?

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38. What is the deficient enzyme in Krabbes disease? accumulated Substrate?






39. _______ can not get inside cells






40. What is the deficient enzyme in Metachromatic leukodystrophy disease? accumulated Substrate?






41. What carries CO2 as energy?






42. How does lactate contribute to gluconeogenesis?






43. What is the purpose of HMP shunt?






44. What is the metabolism of galactose like?






45. What two enzymes are the apart of the same complex? What dictates What form they are in? and What dictates that?






46. Where does gluconeogenesis occur?






47. Name two antineoplastic drugs that work by inhibiting the mitotic spindle by MT blocking.






48. What converts tyrosine to DOPA? What cofactor is used?






49. In What syndrome is HGPRT deficient? What is the inheritance pattern?






50. What type exonuclease activity does DNA polymerase III have? in What organisms is it found?

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