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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. With hypervitaminosis D you will see increased ______ - it causes bone turnover - and stimulates osteoblasts also






2. How do you treat fructose intolerance?






3. What do statins inhibit?






4. What converts pyruvate to Acetyl CoA ? What allosterically downregulates this enzyme?






5. What causes fat soluble vitamin deficiencies?






6. What is the deficient enzyme in Von Gierkes disease? What are the findings?






7. What converts dihydrobioterin back to tetrahydrobioterin factor? What energy carrier is used? in What reactions is this cofactor used?






8. CFTR channel ______ Cl into sweat - secretes NaCl in luminal secretions






9. What aa becomes essential with phenylketonuria?






10. On Which side of the cytoplasm is the ATP site in the Na+K+ ATPase pump? is a phosphorylated pump active or inactive?






11. in Fabrys - What accumulates in tissue because fibroblasts express the def enzyme highly?






12. What cofactor is necessary for conversion of dopamine to NE? NE to epinephrine?






13. What are chromosomes? during What part of the cell cycle are they found? in What pathologic state would you see a lot of chromosomes?






14. What disease is associated with chromosome 21?

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15. What toxins prevent elongation in translation in humans (by binding 40s)?






16. How many bonds does a G- C connection have? What type of bonds? how about a A- T?






17. From What aa does GABA come from? with What enzyme? and What vit cofactor? What does GABA stand for?






18. How do you differentiate causes of megaloblastic anemia?






19. What happens to S adenosyl methionine after it donates a methyl? What enzyme regenerates methionine? What two factors are necessary to do this? who gives the methyl?






20. Heterozygous females in X linked recessive disease...






21. Coris glycogen storage disease has...






22. What are the cofactors required for pyruvate dehydrogenase?






23. What reactions occur in the mitochondrial matrix? mit inner membrane?






24. What is the source of Biotin?






25. How do you treat niacin deficiency do to corn based diet?






26. Why can't muscle participate in gluconeogenesis - What key enzyme does it lack?






27. What is the function of B2? What can cause deficiency?






28. Glycogenolysis ________ maintains blood sugar






29. Which TCA cycle enzyme is found in the inner mit membrane? Where are the rest found?






30. What type of disease is I cell disease? What is deficient?






31. What enzyme is deficient in Fructose intolerance? What is the result of the enzyme def? What are the symptoms?






32. What is the purpose of the PCR?






33. What are two examples of X linked Autosomal Dominant disease?






34. What causes gout in alcoholism?






35. What happens in an aminotransferase reaction






36. Where are cilia found? What symptoms are associated with kartageners syndrome?






37. High blood levels of fructose - galactose - glucose can result in conversion to osmotically active alcohol forms by...






38. Where is there decreased hydrogen concentration in the mit? increased?






39. From What aa does glutathione come from?






40. What is the primary source of nitrogen in the urea cycle






41. What are rotenon - CN - antimycin A - CO?






42. What are the findings in ornthinie transcarbamoylase?






43. What two enzymes are the apart of the same complex? What dictates What form they are in? and What dictates that?






44. GMP is degraded to guanosine Which is degraded to guanine. What two options are next? by What enzymes?






45. What type of exonuclease activity does DNA polymerase I have? in What organisms is it found? What is it used for?

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46. Findings for McArdle's disease? deficient enzyme?






47. other than in the kidney - Where else are gluconeogenesis enzymes found?






48. What 3 genetic disorders can cause Marfanoid habitus?






49. Where does gluconeogenesis occur?






50. What is the first step in the respiratory burst/oxidative burst? in What disease is this deficient?







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