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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. The ________ is 50% cholesterol - 50% phoshpolipids






2. IMP is degraded to inosine and then to hypoxanthine. What two options are next? by What enzymes?






3. What is the exception to the universal aspect of the genetic code?






4. What is the function of mitDNA?






5. What is the purpose of HMP shunt?






6. What disease is associated with chromosome 5?






7. Prokaryotes have What ribosomal units?






8. What else becomes cystic often in APCKD? other than cystic presentations What else do APCKD patients present with?






9. The main hormonal regulation of glycogen is...






10. What type of exonuclease activity does DNA polymerase I have? in What organisms is it found? What is it used for?

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11. What is retinoic acid used for in treatments?






12. The __________ adds O linked oligosaccharides to serine and threonine residues on proteins






13. What is the rate determining enzyme in glycogenolysis?






14. What carries electrons (as energy)?






15. What does the TCA cycle produce?






16. What is the link between adenosine deaminase deficiency and decreased lymphocyte count?






17. What is ascorbic acid? What is its 5 main function?






18. AD disease...






19. What structures allows for degeneracy?






20. What is osmotic damage and What molecules cause it? give some examples of osmotic damage - in What disease state do you see these?






21. Which amino acids are basic? are they negatively or positively charged at body pH?






22. What is Pleiotropy? What is the opposite of Pleiotropy? Give an example of each.






23. why does a deficiency in ornithine transcarbamoylase (urea cycle enzyme) result in an increased production of orotic acid - the pyrimidine precursor?






24. What are two examples of X linked Autosomal Dominant disease?






25. What causes an excess of B3? What are the symptoms?






26. What Ab class blocks DNA gyrase?






27. What is the reason for blue sclerae in Osteogenesis Imperfecta?






28. Which vitamin keeps Fh4 in its reduced form?






29. What is the rate determining enzyme in steroid synthesis? cholesterol synthesis?






30. Where does a majority of galactose in our diet come from?






31. What is the rate determining enzyme in fructose metabolism?






32. What is required to get Acyl coA in FA degradation into the mitochondria for beta oxidation to acetyl coA groups?






33. What does FISH stand for? What is it used for? Give an example.






34. What is the main aa composition of collagen? What other 2 aa are common?






35. What happens to S adenosyl methionine after it donates a methyl? What enzyme regenerates methionine? What two factors are necessary to do this? who gives the methyl?






36. What is a common result of unbalanced robertsonian translocation?






37. What disease is associated with chromosome 18?






38. What is the treatment for phenylketonuria?






39. What does methotrexate do? What step is this enzyme involved in?






40. After addition of an aa - Where does the aminoacyl tRNA now bind to?






41. Is heterochromatic more accessible or less accessible to TF? euchromatin?






42. What is the rate determining enzyme in HMP shunt?






43. Which oxidant is most attributable to damage of RBCs?






44. How do you treat orotic aciduria? How does this work?






45. What is the degradation product of Norepinephrine?






46. What kind of kinetics does alcohol dehydrogenase work under? What are the implications of this?






47. _____________ prevents fluidity of plasma membrane






48. What is the findings in Fabrys disease?






49. What are stable/quiescent cells? Which cells are stable?






50. What is carnitine deficiency and What does it result in?







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