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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What Abs block the binding between aminoacyl tRNA and rRNA by binding the 30S ribosome?






2. Loss of heterozygosity is the rule for...






3. What is the mode of inheritance of Marfans?






4. What is the inheritance pattern of hereditary hemorrhagic telangiectasia or Olser Weber Rendu Syndrome? What is it?






5. What are the two main function of Vit E?






6. How do you treat fructose intolerance?






7. What is the effect of defiiency of VIt E?






8. What type of aa are histones made of? are they acidic or basic?






9. How does fructose enter glycolysis? galactose?






10. What are the two most common aminotransferase and What amino acids do they turn to What glycolytic intermediates?






11. Name a few intermediate filament defects. hints: alcohol - 2 neuro dx

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12. Which Hurlers is milder and presents with no corneal clouding?






13. How does insulin both deactivate glycogenolysis and activates glycogenesis at same time?






14. Are histones in heterochromatin or euchromatin more methylated? Which had more acetylated histones?






15. What enzyme converts DHF to THF? What vitamin cofactor is used to transfer a methyl from an amino acid to DHF? What amino acid is that?






16. What 3 genetic disorders can cause Marfanoid habitus?






17. What is the deficient enzyme in Fabry's disease? accumulated Substrate?






18. What is the deficient enzyme in Tay Sachs disease? accumulated Substrate?






19. What does 6 mercaptopurine do?






20. What type of disorders are associated with chromosomes 13 -14 -15 -21 -22?






21. why does galactose def present in newborns>






22. From What is pyruvate produced in glycolysis? but What enzyme? What enhances that enzyme? downregulates it?






23. What is the precursor in the skin that the sun turns to D3?






24. fatty acid synthase requires ...






25. Which form of iron is most absorbable? What form is non heme ingested iron in (vegetables for ex)?






26. What enzyme is deficient in Fructose intolerance? What is the result of the enzyme def? What are the symptoms?






27. RER adds ___________ to asparagines






28. What disease is associated with chromosome 3?






29. Which RNA polymerase synthesizes tRNAs and snRPs?






30. What is rickets? What is it caused by?






31. What is the degradation product of Norepinephrine?






32. What inheritance pattern is Type IIA hypercholesterolemia? do heterozygotes present with disease? do homozygotes present?






33. What enzyme is deficient in maple syrup disease? What does it result in?






34. What are two reasons why pyruvate would be pushed to lactate in an alcoholic?






35. Kwashiokor patients are not...






36. What is given to prevent side effects When methotrexate is given? why does this work?






37. What can cause a vit C deficiency?






38. What are the findings in Metachromatic leukodystrophy?






39. What causes an excess of B3? What are the symptoms?






40. What is most often mutated in xeroderma pigmentosum? What is the inheritance pattern? What are the clinical symptoms?






41. Other than the H2O2 produced from the resp burst in infections - What other things does G6PD reproduce NADPH for glutathione reduction for? What cells are particularly vulnerable to these oxidizing agents?






42. What toxins prevent elongation in translation in humans (by binding 40s)?






43. What is the other name of B3? What is its function? Synthesis of B3 requires What other vitamin? What else?






44. What is the fate of the two products of lipolysis?






45. What are two examples of X linked Autosomal Dominant disease?






46. What is etoposide? why does this not affect normal healthy cells?






47. What enzyme converts norepinephrine to epinephrine? using What cofactor?






48. What causes fat soluble vitamin deficiencies?






49. What are the clinical findings in patau syndrome?






50. What two substrates (other than pyruvate) does pyruvate carboxylase require?







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