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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
  • If you are not ready to take this test, you can study here.
  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What is dysgeusia?






2. Give examples of the anabolic processes that NADPH participates in. From What process is NADPH produced?






3. What is the result of arginase deficiency?






4. What is the mode of inheritance for the multiple endocrine neoplasias?






5. Do RNA polymerases have proofreading function? What does this mean for HIV?






6. Which aa are only ketogenic?






7. Why do mitochondrial diseases exhibit variable expression?






8. What is the deficient enzyme in Fabry's disease? accumulated Substrate?






9. What is the difference between rickets and osteomalacia?






10. No offspring of affected males with a mit disease can...






11. What are the general symptoms of 22q11 chromosomal deletion? why is it that these occur?






12. Name two diseases that have to do with elastin; discuss their pathogenesis.






13. What two compounds provide the two N's of urea? What else is in urea other than two NH2's?






14. What is the inheritance pattern of hereditary spherocytosis?






15. Which cell types have a high level of RER?






16. What is def of Vit E caused by?






17. How would one use a PCR to id an RNA virus?






18. From What aa does dopa come from?






19. What are two examples of X linked Autosomal Dominant disease?






20. Is DNA acidic or basic?






21. What toxin causes liver failure by inhibiting RNA polymerase II if ingested? Where does it come from?






22. Which form of iron is most absorbable? What form is non heme ingested iron in (vegetables for ex)?






23. What happens to S adenosyl methionine after it donates a methyl? What enzyme regenerates methionine? What two factors are necessary to do this? who gives the methyl?






24. What is the other name for Vitamin B5? What is its function?






25. What is the importance of folic acid?






26. What is the precursor for pyrimidines?






27. Where is type 1 collagen found?






28. What else decreases production of oxaloacetate in alcoholism other than decreased pyruvate?






29. Glucokinase is a...






30. What causes hypoglycemia in alcoholism?






31. What are causes of zinc deficiencies?






32. What is the rate limiting step in fatty acid synthesis? What four things inhibit this rate limiting step? What stimulates it?






33. What type of enyzmes are used in base excision repair?






34. ____ soluble vitamins are more likely to result in toxicity






35. What is the presentation of G6PD deficiency?






36. What is the treatment for cystinuria?






37. What is hartnup disease? What is the mode of inheritance?






38. Where is anaerobic glycolysis used often?






39. What does guanine have on it?






40. What are the clinical findings in edwards syndrome?






41. What is alternative splicing? in What disease state does alt splicing occur unintentionally d/t early stop codons?






42. From What aa does niacin come from? with What vitamin cofactor?






43. What is PRPP? How is it made?






44. The result of dephosphorylation of PFK2 is...






45. What are the symptoms of B2 deficiency?






46. What does actin/myosin participate in?






47. What disease is associated with chromosome 13?






48. What is the source of ATP after a meal?






49. Other than ragged red fibers and lactic acidosis - What else is common in mit myopathies?






50. What is the inheritance pattern of hereditary hemorrhagic telangiectasia or Olser Weber Rendu Syndrome? What is it?