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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What creates a frameshift mutation? What are some clinical examples?






2. What is the degradation product of epinephrine?






3. What does Vit D stimulation of osteoblasts do?






4. Which catecholamine has inhibitory action against acetylcholine?






5. What is the main use of glycogen?






6. What is another way to trap glucose in cells but not by phosphorylating it? What enzymes are used?






7. What is the order of cell cycle phases? What happens in each phase?






8. Which TCA cycle enzyme is found in the inner mit membrane? Where are the rest found?






9. On a 100 meter sprint What is used as energy? in general What is the rule with exercise? What is used in 1000 meter run?






10. What is cystinuria due to?






11. What does a def in folic acid cause? is it more or less common than cobalamin def? How do you differentiate it with cobalamin def?






12. What lysosomal storage diseases are seen more in Ashkenazi Jew?






13. What is the treatment for cystinuria?






14. What drug blocks ribonucleotide reductase? What does this enzyme do?






15. What are some catalase positive bugs?






16. What carries activated Phosphate groups?






17. What else decreases production of oxaloacetate in alcoholism other than decreased pyruvate?






18. What does alcohol do to the P450 system?






19. Insulin acts on __________ to deactivate glycogenolysis






20. What converts dopamine to norepinephrine? using What cofactor?






21. What causes liver damage in kwashiokor?






22. How many enzymes does the pyruvate dehydrogenase complex have? and How many cofactors? Where is it located? to What enzyme is it similar to?






23. What is the inheritance of Von Hippel Lindau disease?






24. What causes hypoglycemia in alcoholism?






25. What are the glucogenic and ketogenic amino acids?






26. What is the source of ATP When you are fasting (in between meals)?






27. What builds up in the urine in homogentistic acid oxidase deficiency? What does this result in ?






28. What are uncoupling agents? What is the result?






29. From What aa does dopa come from?






30. What aa does tyrosine come from?






31. From What aa do the catecholamines come from? and What aa does that aa come from?






32. What are two clinical symptoms of newborns with CF? and whats a lab value of a newborn with CF?






33. How does glycerol from triacylglycerols in adipose tissue used for gluconeogenesis?






34. What does oligomycin do?






35. Because electron transport continues...






36. What form of Vitamin D is in plants? milk fortified with vit D? formed in sun exposed skin?






37. What is uniparental disomy? give an example of a disease it can cause.






38. Is PRPP added later or first in pyrimidine synthesis?






39. What are causes of zinc deficiencies?






40. Name a few intermediate filament defects. hints: alcohol - 2 neuro dx

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41. What are labile cells? Which cells are labile?






42. Which amino acids are required during periods of growth?






43. How is entry into cell cycle phases regulated?






44. What disease is associated with chromosome 13?






45. polymerase chain reaction (PCR)- Name an application for it






46. What disease manifestations result in Prader Willi syndrome? is the deletion a result from the father or mothers chromosome?






47. _______ can not get inside cells






48. What is the rate limiting step in fatty acid synthesis? What four things inhibit this rate limiting step? What stimulates it?






49. What are the clinical symptoms of NF2?






50. Where are secreted proteins synthesized? Where are cellular/organellar proteins synthesized?







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