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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What aa does tyrosine come from?






2. What causes liver damage in kwashiokor?






3. What is the deficient enzyme in Metachromatic leukodystrophy disease? accumulated Substrate?






4. What is the primary source of nitrogen in the urea cycle






5. Which drug blocks the Na+K+ pump by blocking the K+ site?






6. What vit def occur from antibiotic use?






7. Which lysosomal storage diseases have enzymes that are def in cells that are neuronal mostly?






8. What are the functions of zinc?






9. From What aa does dopa come from?






10. Walk through the process that adipose tissue makes triacylglycerol.






11. What is a nissl body?






12. What is the degradation product of Norepinephrine?






13. Findings for McArdle's disease? deficient enzyme?






14. What two anti - neoplastic drugs work by blocking DNA and RNA polymerase?






15. Breast milk has a little of...






16. What converts fructose 2 -6 phosphate back to fructose 2 phosphate?






17. why is there decreased immunity in kwashiokor and marasmus?






18. What can cause an excees of vit A? What are the symptoms?






19. What is there on increased risk of with Downs?






20. What does actin/myosin participate in?






21. What are the two disorders of galactose metabolism? Which is worse?






22. Which is the rate limiting step of the urea cycle?






23. What are the types of lipids found in the plasma membrane?






24. What is needed after the glycosylase in base excision repair?






25. What is calcitriol?






26. other than bone resorption to release Ca and phosphate - What is the ultimate point of increasing the serum Ca2+ and phosphate?






27. How is CF diagnosed?






28. What is the deficient enzyme in Tay Sachs disease? accumulated Substrate?






29. What structures allows for degeneracy?






30. What syndrome is characterized by hyperextensible skin and joints - and bleeding? What is the most common reason? What are other clinical symptoms?






31. Where do aminotransferase reactions occur? and What vitamin cofactor do they require?






32. Which antihelminthic drugs act on microtubules?






33. What is the main clinical presentation of hartnup disease?






34. What is the first enzyme step in glycogenolysis? What activates it ? inactivates?






35. What can cause deficiency in Vit K?






36. What disease is associated with chromosome 4?






37. AD diseases are usually...






38. What is elastin? How is it different from collagen? Where is it found? How is it broken down?






39. What is the presentation for cystinuria?






40. What dictates whether a cell will regenerate or repair after inflammation?






41. What are the key intermediates in the TCA?






42. What control over pyruvate kinase does insulin have?






43. What is the rate determining enzyme in glycogenolysis?






44. All the glycogen storage diseases...






45. What dose a deficiency in Vit B12 cause? What causes it?






46. Where is antioxidant activity of Vit E most important?






47. Is heterochromatic more accessible or less accessible to TF? euchromatin?






48. why does galactose def present in newborns>






49. What converts dopa into melanin?






50. What is uniparental disomy? give an example of a disease it can cause.







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