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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
  • Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.

This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. What can cause a def in vit D?






2. What is an ELISA? What are the two ways to perform it? What is the sensitive and specificity? give a relative clinical example.






3. How do you detect the different reasons that cause cobalamin def?






4. What type of aa is phenylalanine? What implications does this have on the presentation of phenylketonuria?






5. What two substrates (other than pyruvate) does pyruvate carboxylase require?






6. other than Acetyl coA inhibiting pyruvate dehydrogenase complex - how else is it ensured that gluconeogenesis is occuring during FA oxidation and not glycolysis?






7. What is the other name of B3? What is its function? Synthesis of B3 requires What other vitamin? What else?






8. AD diseases are usually...






9. What three enzymes lead to orotic acid accumulation? What reactions are they involved in?






10. What is the rate determining enzyme in HMP shunt?






11. Sporadic Retinoblastoma results is unilateral - but only familial is associated with...






12. In What stage of the cell cycle must cells be in order to be analyzed for karyotyping? and From What fluids can you draw the cells? and for What is karyotyping is used for?






13. Which Hurlers is milder and presents with no corneal clouding?






14. What is the impetus for ketoacidosis in starvation? alcoholism?






15. What converts dopamine to norepinephrine? using What cofactor?






16. On a 100 meter sprint What is used as energy? in general What is the rule with exercise? What is used in 1000 meter run?






17. What is ascorbic acid? What is its 5 main function?






18. What disease is associated with chromosome 7?






19. What type of disease is MERRF? What is the clinical presentation?






20. No offspring of affected males with a mit disease can...






21. What regulates Fructose 1 -6 bisphosphatase? What reaction is it found in?






22. AD disease...






23. What is the rate determining enzyme in TCA cycle?






24. What are five clinical features seen in Osteogenesis Imperfecta?






25. What step in pyrimidine synthesis requires aspartate?






26. What is the first step in the respiratory burst/oxidative burst? in What disease is this deficient?






27. What is the mcc of an autosomal trisomy?






28. Fructose 2 -6 bisphophate is involved in...






29. What is acyl coA dehydrogenase used in? What does a deficiency in this enzyme produce?






30. What carries 1 carbon units as energy?






31. What are the clinical symptoms that result from I cell disease?






32. Glucokinase has a LOW affinity (high Km) and...






33. What is the metabolism of fructose?






34. What is the deficient enzyme in Von Gierkes disease? What are the findings?






35. What goes on with G0 cell cycle phase?






36. NAD+ is used in catabolic processes and NADPH is used in...






37. in Fabrys - What accumulates in tissue because fibroblasts express the def enzyme highly?






38. What is the RNA called before processing? and after?






39. How is urea measured






40. How are fa oxidation and gluconeogenesis linked - ie What compound makes sure that they occur together and that glycolysis doesnt occur?






41. What converts dUMP to dTMP? What drug blocks this?






42. What are ragged red fibers?






43. What disease is associated with chromosome 4?






44. Name two diseases that have to do with elastin; discuss their pathogenesis.






45. What happens in an aminotransferase reaction






46. Which intermediate filament is found connective tissue? muscle? epithelial cells? neuroglia? neurons? What can intermediate filaments be used for?






47. What are the symptoms of cri du chat syndrome? What is the pathogenesis?






48. What can cause a vit C deficiency?






49. What contributes to the acidosis in alcoholism?






50. What carries methyl groups as energy?







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