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USMLE Step 1 Biochemistry

Instructions:
  • Answer 50 questions in 15 minutes.
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  • Match each statement with the correct term.
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This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Can a disorder be congential but not hereditary?

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2. What are two examples of X linked Autosomal Dominant disease?






3. Prokaryotes have What ribosomal units?






4. What experiment is chromosomes used for?






5. What two processes maintain the plasma glucose levels?






6. What is the most common human enzyme deficiency? why? What is the mode of inheritance of this deficiency?






7. Which intermediate filament is found connective tissue? muscle? epithelial cells? neuroglia? neurons? What can intermediate filaments be used for?






8. Where is anaerobic glycolysis used often?






9. What is the most common disorder of the urea cycle? What is the result? What is its mode of inheritance? What is the mode of inheritance of the other urea cycle enzyme def?






10. Breast milk has a little of...






11. What negatively regulates dopamine to norepinephrine?






12. The mode of inheritance for both NF disease is...






13. What are chromosomes? during What part of the cell cycle are they found? in What pathologic state would you see a lot of chromosomes?






14. What is type II collagen found?






15. Which vitamin keeps Fh4 in its reduced form?






16. What is the precursor for pyrimidines?






17. What are the two molecular proteins that are used on MT for transporting in neurons? Which direction do they go?






18. Coris glycogen storage disease has...






19. Which antioxidant does cigarette smoke injury eat up? Which antioxidant does LDL injury eat up?






20. What is the exception to the universal aspect of the genetic code?






21. Amino acids are found in...






22. HMG coA synthase; cholesterol synthesis






23. in What disease are there antibodies to snRNPs?






24. What are the clinical symptoms of NF1?






25. What type of polymerase is primase?






26. When are there low levels of cAMP? What does this result in?






27. If a cell has a hyperchromatic or condensed nucleus is it undergoing transcription etc?






28. How do you treat fructose intolerance?






29. What are three ketone bodies? Which is not detected in urine? Which do you see most in alcoholic ketoacidosis?






30. Which catecholamine has inhibitory action against acetylcholine?






31. What contributes to the acidosis in alcoholism?






32. What aa does AUG mRNA code for in eukaryotes? prokaryotes?






33. Where does gluconeogenesis occur?






34. What form of Vitamin D is in plants? milk fortified with vit D? formed in sun exposed skin?






35. What is the other name of B3? What is its function? Synthesis of B3 requires What other vitamin? What else?






36. What enzyme is involved in the degradation of tyrosine to fumarate?






37. other than in the kidney - Where else are gluconeogenesis enzymes found?






38. What is the deficient enzyme in Tay Sachs disease? accumulated Substrate?






39. What drug blocks alcohol dehydrogenase? What is it used for?






40. What is hartnup disease? What is the mode of inheritance?






41. What enzyme converts norepinephrine to epinephrine? using What cofactor?






42. Is heterochromatic more accessible or less accessible to TF? euchromatin?






43. What is 'charging' of tRNA? What enzyme regulates this? What does this reaction require? in What process is this?






44. What disease is associated with chromosome 17?






45. What is the treatment of hyperammonia?






46. What is the main hormonal regulation of glycogen?






47. What is heteroplasmy?






48. From What aa does porphyrin come from? What is porphyrin the precursor of?






49. What is the rate determining enzyme in urea cycle?






50. What is the mcc of an autosomal trisomy?







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