SUBJECTS
|
BROWSE
|
CAREER CENTER
|
POPULAR
|
JOIN
|
LOGIN
Business Skills
|
Soft Skills
|
Basic Literacy
|
Certifications
About
|
Help
|
Privacy
|
Terms
|
Email
Search
Test your basic knowledge |
USMLE Step 1 Prep 2
Start Test
Study First
Subjects
:
health-sciences
,
usmle-step-1
Instructions:
Answer 50 questions in 15 minutes.
If you are not ready to take this test, you can
study here
.
Match each statement with the correct term.
Don't refresh. All questions and answers are randomly picked and ordered every time you load a test.
This is a study tool. The 3 wrong answers for each question are randomly chosen from answers to other questions. So, you might find at times the answers obvious, but you will see it re-enforces your understanding as you take the test each time.
1. Chediak - Higashi disease (congenital failure of phagolysosome formation)
Pancreatic - pituitary - parathyroid tumors
Stippled vaginal epithelial cells
Vasculitis from exposure to endotoxin casuing glomerular thrombosis
Large lysosomal vesicles in phagocytes - immunodeficiency
2. NF (1 = optic glimoas and pheo - 2 = acoustic Schwannomas)
Caf
Basophilic nuclear remnants in RBCs
Recurrent colds - unusual eczema - high serum IgE
Antineutrophil cytoplasmic antibodies (ANCA)
3. Schiller - Duval bodies (yolk sac tumor)
Infant with failure to thrive - hepatosplenomegaly - neurodegeneration
Extracellular amyloid deposition in gray matter of brain
Green -yellow rings around peripheral iris
Glomerulus - like structure surrounding vessel in germ cells
4. Lead poisoning or sideroblastic anemia
Basophilic stipplling of RBCs
Chorea - dementia - caudate degeneration
Cellular crescents in Bowman's capsule
hematuria - bladder cancer (parasite)
5. Wegner's (c - ANCA) and Goodpasture's (anti - GBM). Wegner's can also have upper airway involvement
Neonate with arm paralysis following difficult birth. Possible clavicle fx - probably large for gestational age
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Necrotizing vasculitis (lungs) and necrotizing GN
Basophilic stipplling of RBCs
6. Kussmaul breathing - DKA
Deep - labored breathing / hyperventilation
Rapidly progressive leg weakness that ascend - following GI infection
Hepatosplenomegaly - osteoporosis - neurologic symptoms - crinkled cytoplasm
Splinter hemorrhages in fingernails
7. Strep pneumo
Rectangular - crystal - like - cytoplasmic inclusions in Leydig cells
Multiple colon polyps - osteomas / soft tissue tumors - impacted / supernumary teeth
Rusty sputum
Cellular crescents in Bowman's capsule
8. Condylomata lata (2* syphilis)
HTN - hypoK - metabolic alkalosis
Lytic (punched - out) bone lesions on X- ray
Child with fever develops red rash on face that spreads to body
Smooth - flat - moist white lesions on genitals
9. Coarctation of the aorta
Honeycomb lung on X- ray
Caf
Rib notching
Skin hyperpigmentation
10. String sign (Crohn's)
Narrowing of bowel lumen on barium radiograph
Thumb sign on lateral X- ray
Cardiomegaly with apical atrophy
Single palm crease
11. Mallory- Weiss syndrome (alcoholic and bulimic patients)
Antinuclear antibodies
Fever - chills - headache - myalgia following antibiotic treatment for syphillis
Vomiting blood following esophagogastric lacerations
Pupil accommodates but doesn't react
12. Epiglossitis (H flu)
Single palm crease
Lumpy- bumpy appearance of glomeruli on immunofluorescence
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Thumb sign on lateral X- ray
13. Babinski (UMN lesion)
Hamartomatous GI polyps - hyperpigmentation of mouth - feet and hands
Toe extension / fanning upon plantar scrape
Enlarged cells with intranuclear inclusion bodies
Circular grouping of dark tumor cells surrounding pale neurofibrils
14. Diphyllobothrium latum
B12 deficiency (parasite)
Green -yellow rings around peripheral iris
Indurated - ulcerated genital lesion
Abdominal pain - ascites - hepatomegaly - (also high D dimer - CHF without JVD)
15. Waterhouse - Friderichsen syndrome (meningococcemia)
Achilles tendon xanthoma
Adrenal hemorrhage - hypotension - DIC
Strawberry tongue
Resting tremor - rigidity - akinesia - postural instability
16. Choriocarcinoma - hydatidiform mole
Infant with failure to thrive - hepatosplenomegaly - neurodegeneration
hCG elevated
B12 deficiency (parasite)
Palpable purpura - joint pain - abdominal pain in a child
17. Multiple myeloma
Giant B cells with bilobed nuclei with prominent inclusions (Owl's eye)
Lytic (punched - out) bone lesions on X- ray
Hilar lymphadenopathy - peripheral granulomatous lesion in middle or lower lung lobes (can calcify)
Bluish line on gingiva
18. Fanconi's syndrome (proximal tubular reabsorption defect)
Pupil accommodates but doesn't react
Antiplatelet antibodies
Polyuria - acidosis - growth failure - electrolyte imbalances
Pink complexion - dypnea - hyperventilation
19. Interstitial fibrosis
Red 'current jelly' sputum in alcoholic or diabetic patients
Resting tremor - rigidity - akinesia - postural instability
Honeycomb lung on X- ray
Hyperphagia - hypersexuality - hyperorality - hyperdocility
20. Guillain - Barre syndrome
Hilar lymphadenopathy - peripheral granulomatous lesion in middle or lower lung lobes (can calcify)
Degeneration of dorsal column nerves
Rapidly progressive leg weakness that ascend - following GI infection
Lytic (punched - out) bone lesions on X- ray
21. Blue bloater (chronic bronchitis)
Intranuclear eosinophilic droplet - like bodies
Current jelly stool
Vascular birthmark (port - wine stain)
Hypoxemia - polycythemia - hypercapnia
22. Goodpasture's syndome (glomerulonephritis and hemoptysis)
perianal pruritis (parasite)
AntiGBM antibodies
Painful - pale - cold fingers / toes
hematuria - bladder cancer (parasite)
23. Becker's muscular dystrophy
Retinal hemorrhages with pale centers
Rhomboid crystals - positively birefringent
Slow progressive muscle weakness in boys
Caf
24. Paroxysmal nocturnal hemoglobinuria (C' mediated damage - lack of CD55/59)
Painless erythematous lesions on palms and soles
Large lysosomal vesicles in phagocytes - immunodeficiency
Dry eyes - dry mouth - arthritis
Red urine in the morning - fragile RBCs
25. Chvostek's sign (hypocalcemia)
Jaundice - RUQ pain - fever
Rapidly progressive leg weakness that ascend - following GI infection
Hypoxemia - polycythemia - hypercapnia
Facial muscle spasm upon tapping
26. CF
Iron - containing nodules in alveolar septum
Colonies of mucoid Pseudomonas in lungs
Hypersegmented neutrophils
Child with fever develops red rash on face that spreads to body
27. Huntington's
Chorea - dementia - caudate degeneration
Dysphagia (esophageal webs) - glossitis (smooth tongue) - iron deficiency anemia
Swollen gums - mucous bleeding - poor wound healing - spots on skin
Waxy casts with very low urine flow
28. Peutz - Jeghers syndrome
Thumb sign on lateral X- ray
Onion - skin periosteal reaction
Hypoxemia - polycythemia - hypercapnia
Hamartomatous GI polyps - hyperpigmentation of mouth - feet and hands
29. CLL (almost always B cell - affects the elderly)
WBCs that look smudged
Child with fever develops red rash on face that spreads to body
Vascular birthmark (port - wine stain)
Antiplatelet antibodies
30. Scleroderma (CREST)
Renal epithelial casts in urine
Skin hyperpigmentation
Monoclonal antibody spike
Anticentromere antibodies
31. Peyronie's disease
Cherry- red spot on macula
Fibrous plaques in soft tissue of penis
Weight loss - diarrhea - arthritis - fever - adenopathy
Antiplatelet antibodies
32. Wet beriberi (B1 / thiamine deficiency)
Slow progressive muscle weakness in boys
Bilateral hilar adenopathy - uveitis
Adrenal hemorrhage - hypotension - DIC
Dilated cardiomyopathy - edema - polyneuropathy
33. Horner's syndrome (usually with Pancoast tumor in apex of lung)
Colonies of mucoid Pseudomonas in lungs
Ptosis - miosis - anhidrosis
Antimitochondrial antibodies
Antihistone antibodies
34. Clonorchis sinensis
Podocyte fusion on EM
Facial muscle spasm upon tapping
Vascular birthmark (port - wine stain)
biliary tract disease - cholangiocarcinoma (parasite)
35. Membranous glomerulonephritis (may progress to nephrotic)
Short stature - increased incidence of tumors / leukemia - aplastic anemia
Spikes on basement membrane - dome - like endothelial deposits
Indurated - ulcerated genital lesion
Chorea - dementia - caudate degeneration
36. Sheehan's syndrome
Painful - pale - cold fingers / toes
No lactation postpartum - absent menstruation - cold intolerance
Weight loss - diarrhea - arthritis - fever - adenopathy
Jaundice - RUQ pain - fever
37. Shwartzman reaction (follows second exposure to endotoxin)
Vasculitis from exposure to endotoxin casuing glomerular thrombosis
Restrictive cardiomyopathy (juvenile = cardiomegaly) - exercise intolerance
Abdominal pain - ascites - hepatomegaly - (also high D dimer - CHF without JVD)
Protein aggregates in neurons from hyperphosphorylation of tau protein
38. Budd - Chiari syndrome
Colonies of mucoid Pseudomonas in lungs
Abdominal pain - ascites - hepatomegaly - (also high D dimer - CHF without JVD)
Stippled vaginal epithelial cells
Honeycomb lung on X- ray
39. Infectious mono (HBV). IgM that agglutinates sheep RBCs
Silver - staining spherical aggregation of tau proteins in neurons
Heterophile antibodies
Degeneration of dorsal column nerves
Palpable purpura - joint pain - abdominal pain in a child
40. Koilocytes (HPV) 'perrinuclear cytoplasmic clearing'
Thyroid - like appearance of kidney
Lytic (punched - out) bone lesions on X- ray
Cellular crescents in Bowman's capsule
Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia
41. Mallory bodies (alcoholic liver disease)
Eosinophilic cytoplasmic inclusion in liver cell
Small - irregular red spots on buccal mucosa with blue - white centers
Gout - MR - self - mutilating behavior in a boy
liver cysts (parasite)
42. Lesch - Nyhan syndrome (HGPRT deficiency - X- linked recessive)
Athlete with polycythemia
Painless erythematous lesions on palms and soles
Gout - MR - self - mutilating behavior in a boy
hCG elevated
43. Tabes dorsalis - lose proprioception (3* syphilis)
Degeneration of dorsal column nerves
High level of D dimers
Swollen - hard - painful finger joints
Toe extension / fanning upon plantar scrape
44. Osler's node (infective endocarditis)
Rib notching
Increased uric acid levels
Child with fever develops red rash on face that spreads to body
Painful - raised red lesions on palms and soles
45. Tetralogy of Fallot - RVH
Recurrent colds - unusual eczema - high serum IgE
Boot - shaped heart on X- ray
Fibrous plaques in soft tissue of penis
Antinuclear antibodies
46. Bacterial endocarditis
Painful blue fingers / toes - hemolytic anemia
Colonies of mucoid Pseudomonas in lungs
Splinter hemorrhages in fingernails
Fever - cough - conjunctivitis - coryza - diffuse rash - Koplick spots
47. Eburnation (OA resulting in bony sclerosis)
Recurrent colds - unusual eczema - high serum IgE
Severe jaundice in neonate
Thyroid (medullary) and parathyroid tumors - pheochromocytoma
Polished - ivory- like appearance of bone at cartilage erosion
48. Councilman body (toxic or viral hepatitis - often yellow fever)
Honeycomb lung on X- ray
Caf
Cardiomegaly with apical atrophy
Eosinophilic globule in liver
49. Job's syndrome
Colonies of mucoid Pseudomonas in lungs
Situs inversus - chronic sinusitis - bronchiectasis - infertility
Recurrent colds - unusual eczema - high serum IgE
Hereditary nephritis - sensorineural hearing loss - cataracts
50. Tay- Sachs - Niemann - Pick - central retinal artery occlusion
Infant with hypoglycemia - failure to thrive - and hepatomegaly
Smooth - flat - moist white lesions on genitals
Lucid interval after TBI
Cherry- red spot on macula